CREMA results: MEIS3

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Transcription factors associated with MEIS3_TGIF2LX

Gene Symbol	Gene ID	Gene Info
MEIS3 Ensembl NCBI GeneCards UniProt	ENSG00000105419.13	Meis homeobox 3
TGIF2LX Ensembl NCBI GeneCards UniProt	ENSG00000153779.8	TGFB induced factor homeobox 2 like X-linked

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

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CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
chr19_47893667_47893818	MEIS3	18667	0.139828	0.51	1.6e-01	Click!
chr19_47902354_47902505	MEIS3	9980	0.157557	0.55	1.3e-01	Click!
chr19_47930779_47930930	MEIS3	8074	0.156354	-0.55	1.2e-01	Click!
chr19_47932297_47932448	MEIS3	9592	0.151645	-0.51	1.6e-01	Click!
chr19_47936281_47936432	MEIS3	13576	0.141825	0.54	1.3e-01	Click!

Showing 1 to 5 of 5 entries

Activity of the MEIS3_TGIF2LX motif across conditions

Conditions sorted by the z-value of the MEIS3_TGIF2LX motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

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Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr16_31364396_31364620	0.40	ITGAX	integrin, alpha X (complement component 3 receptor 4 subunit)	1947	0.22
chr1_37195687_37195944	0.40	RP4-614N24.1		42926	0.19
chr5_59090911_59091107	0.38	PDE4D	phosphodiesterase 4D, cAMP-specific	26538	0.25
chr2_57825828_57826109	0.36	ENSG00000212168	.	54298	0.18
chr2_65132087_65132267	0.36	ENSG00000244534	.	2095	0.28
chr15_94406442_94406593	0.35	ENSG00000222409	.	33739	0.25
chr3_53206532_53206683	0.34	PRKCD	protein kinase C, delta	7462	0.18
chr3_34304883_34305090	0.33	PDCD6IP	programmed cell death 6 interacting protein	464871	0.01
chrX_123521860_123522011	0.32	SH2D1A	SH2 domain containing 1A	41496	0.21
chr1_87771024_87771216	0.32	LMO4	LIM domain only 4	23031	0.26

Showing 1 to 10 of 200 entries

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of MEIS3_TGIF2LX

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.3	GO:0051865	protein autoubiquitination(GO:0051865)
0.1	0.2	GO:0032959	inositol trisphosphate biosynthetic process(GO:0032959)
0.1	0.2	GO:0035234	ectopic germ cell programmed cell death(GO:0035234)
0.0	0.2	GO:0031272	pseudopodium assembly(GO:0031269) regulation of pseudopodium assembly(GO:0031272) positive regulation of pseudopodium assembly(GO:0031274)
0.0	0.2	GO:0015884	folic acid transport(GO:0015884)
0.0	0.2	GO:0051155	positive regulation of striated muscle cell differentiation(GO:0051155)
0.0	0.2	GO:0030851	granulocyte differentiation(GO:0030851)
0.0	0.2	GO:0050732	negative regulation of peptidyl-tyrosine phosphorylation(GO:0050732)
0.0	0.1	GO:0045906	negative regulation of vasoconstriction(GO:0045906)
0.0	0.1	GO:0000101	sulfur amino acid transport(GO:0000101) L-cystine transport(GO:0015811)

Showing 1 to 10 of 65 entries

Gene overrepresentation in cellular component category:

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Total log-likelihood	Term	Description
0.1	GO:0009331	glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.1	GO:0031265	CD95 death-inducing signaling complex(GO:0031265)
0.1	GO:0033268	node of Ranvier(GO:0033268)
0.1	GO:0005915	zonula adherens(GO:0005915)
0.1	GO:0043190	ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.1	GO:0008290	F-actin capping protein complex(GO:0008290)
0.1	GO:0034362	low-density lipoprotein particle(GO:0034362)
0.1	GO:0031941	filamentous actin(GO:0031941)
0.1	GO:0005663	DNA replication factor C complex(GO:0005663)
0.0	GO:0071664	catenin-TCF7L2 complex(GO:0071664)

Showing 1 to 10 of 13 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.3	GO:0019212	phosphatase inhibitor activity(GO:0019212)
0.1	0.2	GO:0001515	opioid peptide activity(GO:0001515)
0.0	0.2	GO:0008518	reduced folate carrier activity(GO:0008518)
0.0	0.2	GO:0004716	receptor signaling protein tyrosine kinase activity(GO:0004716)
0.0	0.2	GO:0030169	low-density lipoprotein particle binding(GO:0030169)
0.0	0.2	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0	0.1	GO:0015184	L-cystine transmembrane transporter activity(GO:0015184)
0.0	0.1	GO:0004367	glycerol-3-phosphate dehydrogenase [NAD+] activity(GO:0004367)
0.0	0.1	GO:0004185	serine-type carboxypeptidase activity(GO:0004185)
0.0	0.1	GO:0047756	chondroitin 4-sulfotransferase activity(GO:0047756)

Showing 1 to 10 of 58 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Total log-likelihood	Term	Description
0.4	SIG PIP3 SIGNALING IN B LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes
0.1	SA B CELL RECEPTOR COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.1	PID TRAIL PATHWAY	TRAIL signaling pathway
0.0	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
0.0	PID PI3KCI AKT PATHWAY	Class I PI3K signaling events mediated by Akt

Showing 1 to 5 of 5 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Total log-likelihood	Term	Description
0.4	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.2	REACTOME REGULATION OF KIT SIGNALING	Genes involved in Regulation of KIT signaling
0.2	REACTOME ERK MAPK TARGETS	Genes involved in ERK/MAPK targets
0.1	REACTOME NOD1 2 SIGNALING PATHWAY	Genes involved in NOD1/2 Signaling Pathway
0.1	REACTOME P2Y RECEPTORS	Genes involved in P2Y receptors
0.0	REACTOME DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR	Genes involved in Downstream Signaling Events Of B Cell Receptor (BCR)
0.0	REACTOME DAG AND IP3 SIGNALING	Genes involved in DAG and IP3 signaling

Showing 1 to 7 of 7 entries

Results for MEIS3_TGIF2LX

Z-value: 1.06

Motif logo

Transcription factors associated with MEIS3_TGIF2LX

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Activity of the MEIS3_TGIF2LX motif across conditions

Conditions sorted by the z-value of the MEIS3_TGIF2LX motif activity

Top target CREs of the motif:

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of MEIS3_TGIF2LX

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: