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ENCODE: H3K4me1 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for MEIS3_TGIF2LX

Z-value: 1.06

Motif logo

Transcription factors associated with MEIS3_TGIF2LX

Gene Symbol	Gene ID	Gene Info
MEIS3 Ensembl NCBI GeneCards UniProt	ENSG00000105419.13	MEIS3
TGIF2LX Ensembl NCBI GeneCards UniProt	ENSG00000153779.8	TGIF2LX

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
MEIS3	chr19_47930779_47930930	8074	0.156354	-0.55	1.2e-01	Click!
MEIS3	chr19_47902354_47902505	9980	0.157557	0.55	1.3e-01	Click!
MEIS3	chr19_47936281_47936432	13576	0.141825	0.54	1.3e-01	Click!
MEIS3	chr19_47893667_47893818	18667	0.139828	0.51	1.6e-01	Click!
MEIS3	chr19_47932297_47932448	9592	0.151645	-0.51	1.6e-01	Click!

Activity of the MEIS3_TGIF2LX motif across conditions

Conditions sorted by the z-value of the MEIS3_TGIF2LX motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr16_31364396_31364620	0.40	ITGAX	integrin, alpha X (complement component 3 receptor 4 subunit)	1947	0.22
chr1_37195687_37195944	0.40	RP4-614N24.1		42926	0.19
chr5_59090911_59091107	0.38	PDE4D	phosphodiesterase 4D, cAMP-specific	26538	0.25
chr2_57825828_57826109	0.36	ENSG00000212168	.	54298	0.18
chr2_65132087_65132267	0.36	ENSG00000244534	.	2095	0.28
chr15_94406442_94406593	0.35	ENSG00000222409	.	33739	0.25
chr3_53206532_53206683	0.34	PRKCD	protein kinase C, delta	7462	0.18
chr3_34304883_34305090	0.33	PDCD6IP	programmed cell death 6 interacting protein	464871	0.01
chrX_123521860_123522011	0.32	SH2D1A	SH2 domain containing 1A	41496	0.21
chr1_87771024_87771216	0.32	LMO4	LIM domain only 4	23031	0.26
chr16_12449826_12449977	0.32	SNX29	sorting nexin 29	209	0.94
chr9_81309923_81310074	0.32	PSAT1	phosphoserine aminotransferase 1	397939	0.01
chr22_47080714_47080865	0.32	GRAMD4	GRAM domain containing 4	10284	0.22
chr1_48711061_48711404	0.31	RP5-1024N4.4		15999	0.21
chr16_89044159_89044400	0.31	CBFA2T3	core-binding factor, runt domain, alpha subunit 2; translocated to, 3	667	0.66
chr9_95876458_95876701	0.31	C9orf89	chromosome 9 open reading frame 89	18079	0.14
chr1_40529943_40530230	0.31	PPT1	palmitoyl-protein thioesterase 1	17907	0.17
chr18_77269712_77269863	0.31	AC018445.1	Uncharacterized protein	6270	0.3
chr14_65519660_65519811	0.30	ENSG00000266531	.	8329	0.14
chr7_76139277_76139433	0.30	UPK3B	uroplakin 3B	390	0.81
chr22_47017621_47018011	0.29	GRAMD4	GRAM domain containing 4	1517	0.48
chr15_68077042_68077264	0.29	SKOR1	SKI family transcriptional corepressor 1	34889	0.2
chr1_43765747_43766019	0.29	TIE1	tyrosine kinase with immunoglobulin-like and EGF-like domains 1	781	0.52
chr16_11593490_11593706	0.28	CTD-3088G3.8	Protein LOC388210	7987	0.15
chr6_34243280_34243535	0.28	C6orf1	chromosome 6 open reading frame 1	26160	0.18
chr2_16844763_16844970	0.28	FAM49A	family with sequence similarity 49, member A	2230	0.47
chr11_2697989_2698156	0.28	KCNQ1OT1	KCNQ1 opposite strand/antisense transcript 1 (non-protein coding)	23152	0.22
chr7_37429580_37430060	0.27	ENSG00000200113	.	29411	0.16
chr6_24951319_24951727	0.27	FAM65B	family with sequence similarity 65, member B	15335	0.22
chr5_34865017_34865168	0.26	CTD-2517O10.6		25709	0.15
chr3_194696258_194696409	0.26	XXYLT1-AS1	XXYLT1 antisense RNA 1	118984	0.05
chr12_7060138_7060323	0.26	PTPN6	protein tyrosine phosphatase, non-receptor type 6	195	0.81
chr11_76047608_76047759	0.26	PRKRIR	protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor)	44303	0.11
chr15_42676695_42676925	0.25	CAPN3	calpain 3, (p94)	17778	0.15
chr11_105090744_105090960	0.25	CARD18	caspase recruitment domain family, member 18	80399	0.1
chr10_131129546_131129832	0.25	MGMT	O-6-methylguanine-DNA methyltransferase	135759	0.05
chr17_56692314_56692465	0.25	ENSG00000212195	.	16808	0.12
chr22_17582429_17582621	0.25	IL17RA	interleukin 17 receptor A	16676	0.14
chr6_47203496_47203647	0.25	TNFRSF21	tumor necrosis factor receptor superfamily, member 21	74070	0.12
chr4_16032933_16033084	0.24	ENSG00000251758	.	22598	0.19
chr16_81529220_81529493	0.24	CMIP	c-Maf inducing protein	402	0.91
chr18_43904157_43904332	0.24	RNF165	ring finger protein 165	2528	0.4
chr1_19235703_19235961	0.24	IFFO2	intermediate filament family orphan 2	2654	0.22
chr9_21047360_21047561	0.24	PTPLAD2	protein tyrosine phosphatase-like A domain containing 2	15825	0.18
chr9_84798219_84798630	0.24	SPATA31D1	SPATA31 subfamily D, member 1	194737	0.03
chr5_78088517_78088668	0.24	LHFPL2	lipoma HMGIC fusion partner-like 2	143944	0.05
chr1_206246898_206247049	0.24	ENSG00000252692	.	14120	0.15
chr7_29308125_29308409	0.24	AC004593.3		59681	0.12
chr12_11939644_11939800	0.24	ETV6	ets variant 6	34287	0.22
chr8_25095577_25095889	0.23	DOCK5	dedicator of cytokinesis 5	53353	0.15
chr11_60939371_60939609	0.23	VPS37C	vacuolar protein sorting 37 homolog C (S. cerevisiae)	10401	0.15
chr21_45595773_45596048	0.23	AP001055.1		2330	0.22
chr8_92363748_92363899	0.23	SLC26A7	solute carrier family 26 (anion exchanger), member 7	55971	0.15
chr1_175809524_175809675	0.23	TNR	tenascin R	96693	0.08
chr19_50018940_50019106	0.23	FCGRT	Fc fragment of IgG, receptor, transporter, alpha	1708	0.13
chr1_230413095_230413246	0.23	RP5-956O18.3		4469	0.26
chr18_21695534_21696122	0.23	TTC39C	tetratricopeptide repeat domain 39C	1591	0.26
chr15_31115309_31115461	0.23	ENSG00000221379	.	21876	0.16
chr6_12943954_12944105	0.23	PHACTR1	phosphatase and actin regulator 1	14185	0.3
chr5_157661766_157661969	0.23	ENSG00000222626	.	257903	0.02
chr13_101325397_101325635	0.23	TMTC4	transmembrane and tetratricopeptide repeat containing 4	1512	0.47
chr2_26232079_26232230	0.23	AC013449.1	Uncharacterized protein	19327	0.15
chr1_19686120_19686271	0.22	CAPZB	capping protein (actin filament) muscle Z-line, beta	26096	0.11
chr15_28413886_28414277	0.22	HERC2	HECT and RLD domain containing E3 ubiquitin protein ligase 2	5488	0.29
chr4_15190631_15190980	0.22	RP11-665G4.1		38779	0.19
chr12_124228990_124229141	0.22	ATP6V0A2	ATPase, H+ transporting, lysosomal V0 subunit a2	5478	0.19
chr17_27889238_27889394	0.22	RP11-68I3.2		1751	0.18
chr9_111885537_111885688	0.22	TMEM245	transmembrane protein 245	3387	0.25
chr21_34439493_34439682	0.22	OLIG1	oligodendrocyte transcription factor 1	2863	0.23
chr10_134235955_134236340	0.22	RP11-432J24.3		18841	0.16
chr12_27155870_27156021	0.22	TM7SF3	transmembrane 7 superfamily member 3	273	0.89
chr2_60627914_60628065	0.22	ENSG00000266078	.	13409	0.22
chr11_70267723_70267874	0.21	CTTN	cortactin	1198	0.41
chr15_57887157_57887308	0.21	GCOM1	GRINL1A complex locus 1	3001	0.22
chr7_115625227_115625506	0.21	TFEC	transcription factor EC	17062	0.28
chr17_48841397_48841548	0.21	LUC7L3	LUC7-like 3 (S. cerevisiae)	17492	0.14
chr19_47233988_47234360	0.21	CTB-174O21.2		2314	0.14
chr22_18253018_18253331	0.21	BID	BH3 interacting domain death agonist	3608	0.22
chr19_31765985_31766213	0.21	AC007796.1		73688	0.11
chr7_93869278_93869476	0.21	COL1A2	collagen, type I, alpha 2	154496	0.04
chr1_229137271_229137454	0.21	RP5-1061H20.5		225947	0.02
chr1_9422560_9422755	0.21	SPSB1	splA/ryanodine receptor domain and SOCS box containing 1	6891	0.25
chr4_40561931_40562177	0.21	RBM47	RNA binding motif protein 47	44064	0.15
chr9_111597664_111597815	0.21	ACTL7B	actin-like 7B	21500	0.19
chr2_225269583_225269734	0.21	FAM124B	family with sequence similarity 124B	2856	0.39
chr1_245424145_245424296	0.20	RP11-62I21.1		26417	0.22
chr19_44297367_44297518	0.20	LYPD5	LY6/PLAUR domain containing 5	6739	0.13
chr21_45631442_45631593	0.20	AP001057.1		10344	0.12
chrX_148713668_148713871	0.20	TMEM185A	transmembrane protein 185A	201	0.94
chr2_64489091_64489290	0.20	AC074289.1		33588	0.2
chr22_26564894_26565205	0.20	SEZ6L	seizure related 6 homolog (mouse)-like	391	0.87
chr12_10186853_10187023	0.20	CLEC9A	C-type lectin domain family 9, member A	3662	0.14
chr12_2639416_2639567	0.20	CACNA1C-AS3	CACNA1C antisense RNA 3	77115	0.1
chr6_111897306_111897457	0.20	TRAF3IP2-AS1	TRAF3IP2 antisense RNA 1	1559	0.37
chr4_86622619_86622800	0.20	ENSG00000266421	.	20912	0.26
chr10_94549884_94550135	0.20	EXOC6	exocyst complex component 6	40926	0.17
chr21_39867625_39867922	0.20	ERG	v-ets avian erythroblastosis virus E26 oncogene homolog	2572	0.43
chr6_20427872_20428026	0.20	ENSG00000252949	.	5400	0.15
chr1_234885846_234885997	0.20	ENSG00000201638	.	87799	0.08
chr10_23389093_23389313	0.20	MSRB2	methionine sulfoxide reductase B2	4768	0.23
chr2_169482878_169483157	0.20	ENSG00000199348	.	20011	0.22
chr2_171218393_171218731	0.20	AC012594.1		10934	0.3
chr12_117463237_117463436	0.20	TESC	tescalcin	21300	0.21
chr6_42343133_42343301	0.19	ENSG00000221252	.	36917	0.17
chr2_233956975_233957215	0.19	INPP5D	inositol polyphosphate-5-phosphatase, 145kDa	31906	0.16
chr19_52124679_52125032	0.19	SIGLEC5	sialic acid binding Ig-like lectin 5	8733	0.11
chr3_4383206_4383357	0.19	SETMAR	SET domain and mariner transposase fusion gene	37989	0.21
chr2_157327257_157327445	0.19	GPD2	glycerol-3-phosphate dehydrogenase 2 (mitochondrial)	2733	0.29
chr5_142596063_142596214	0.19	ARHGAP26	Rho GTPase activating protein 26	9373	0.25
chr1_16827341_16827546	0.19	CROCCP3	ciliary rootlet coiled-coil, rootletin pseudogene 3	9641	0.13
chr12_111587807_111587958	0.19	CUX2	cut-like homeobox 2	50632	0.15
chr19_18090395_18090751	0.19	ENSG00000252591	.	7739	0.14
chr11_3188344_3188495	0.19	OSBPL5	oxysterol binding protein-like 5	1419	0.35
chr10_81698298_81698654	0.19	SFTPD	surfactant protein D	10383	0.26
chr17_61753634_61753814	0.19	LIMD2	LIM domain containing 2	22798	0.13
chr10_50507704_50507855	0.19	C10orf71	chromosome 10 open reading frame 71	541	0.55
chr5_135347344_135347609	0.19	TGFBI	transforming growth factor, beta-induced, 68kDa	17108	0.2
chr6_37017148_37017362	0.19	COX6A1P2	cytochrome c oxidase subunit VIa polypeptide 1 pseudogene 2	4648	0.23
chr4_174202594_174202800	0.19	GALNT7	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 7 (GalNAc-T7)	10585	0.17
chr22_26972149_26972362	0.19	TPST2	tyrosylprotein sulfotransferase 2	10563	0.15
chr18_74769125_74769276	0.19	MBP	myelin basic protein	39466	0.19
chr4_109901475_109901626	0.19	COL25A1	collagen, type XXV, alpha 1	156175	0.04
chr2_64694768_64695032	0.19	LGALSL	lectin, galactoside-binding-like	13224	0.19
chr7_50251693_50252080	0.19	AC020743.2		69467	0.11
chr10_88117437_88117588	0.19	GRID1	glutamate receptor, ionotropic, delta 1	8723	0.24
chr4_55557239_55557390	0.19	KIT	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	33229	0.24
chr7_87944172_87944366	0.18	STEAP4	STEAP family member 4	8063	0.23
chr20_20037098_20037366	0.18	C20orf26	chromosome 20 open reading frame 26	58	0.9
chr1_21510914_21511065	0.18	EIF4G3	eukaryotic translation initiation factor 4 gamma, 3	7612	0.21
chr6_44585641_44585792	0.18	ENSG00000266619	.	182338	0.03
chr6_159461301_159461469	0.18	TAGAP	T-cell activation RhoGTPase activating protein	4665	0.21
chr11_33952668_33952907	0.18	LMO2	LIM domain only 2 (rhombotin-like 1)	38951	0.16
chrX_128913033_128913442	0.18	SASH3	SAM and SH3 domain containing 3	723	0.69
chr10_101940587_101940738	0.18	ERLIN1	ER lipid raft associated 1	5124	0.15
chr3_126248151_126248302	0.18	CHST13	carbohydrate (chondroitin 4) sulfotransferase 13	5100	0.16
chr17_72329157_72329308	0.18	KIF19	kinesin family member 19	6881	0.11
chr4_55529764_55530043	0.18	KIT	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	5818	0.34
chr9_135757349_135757570	0.18	C9orf9	chromosome 9 open reading frame 9	3174	0.17
chr13_32691700_32692027	0.18	FRY	furry homolog (Drosophila)	56862	0.14
chr21_46954664_46954827	0.18	SLC19A1	solute carrier family 19 (folate transporter), member 1	216	0.95
chr11_75091839_75092030	0.18	RPS3	ribosomal protein S3	18596	0.11
chr18_42882859_42883010	0.18	SLC14A2	solute carrier family 14 (urea transporter), member 2	89974	0.09
chr12_111618066_111618305	0.18	CUX2	cut-like homeobox 2	80935	0.09
chr2_127818917_127819068	0.18	ENSG00000238788	.	43995	0.16
chr10_11155205_11156000	0.18	CELF2-AS2	CELF2 antisense RNA 2	15166	0.21
chr7_139585204_139585374	0.18	TBXAS1	thromboxane A synthase 1 (platelet)	56179	0.14
chr8_70591137_70591370	0.18	ENSG00000222889	.	21206	0.21
chr11_44938433_44938696	0.18	TSPAN18	tetraspanin 18	10606	0.25
chr11_65084227_65084378	0.18	CDC42EP2	CDC42 effector protein (Rho GTPase binding) 2	211	0.9
chr16_57712273_57712424	0.18	GPR97	G protein-coupled receptor 97	10128	0.13
chr5_132644386_132644537	0.18	CTB-49A3.4		42184	0.15
chr6_12659751_12659902	0.18	PHACTR1	phosphatase and actin regulator 1	58067	0.15
chr19_35950537_35950782	0.17	FFAR2	free fatty acid receptor 2	10042	0.11
chr9_135685079_135685230	0.17	RP11-295G24.5		39555	0.12
chr4_144278414_144278571	0.17	ENSG00000265623	.	13879	0.2
chr20_58566781_58566961	0.17	CDH26	cadherin 26	2710	0.28
chr6_53600725_53601075	0.17	RP13-476E20.1		58172	0.11
chr4_40310355_40310506	0.17	CHRNA9	cholinergic receptor, nicotinic, alpha 9 (neuronal)	26916	0.19
chr5_108994298_108994449	0.17	ENSG00000266090	.	26908	0.19
chr19_19653103_19653257	0.17	CILP2	cartilage intermediate layer protein 2	4106	0.13
chr17_397150_397301	0.17	RP5-1029F21.3		9186	0.19
chr2_238828434_238828585	0.17	UBE2F	ubiquitin-conjugating enzyme E2F (putative)	47088	0.12
chr8_10053593_10053832	0.17	MSRA	methionine sulfoxide reductase A	100475	0.07
chr16_68775300_68775451	0.17	ENSG00000200558	.	1008	0.48
chr2_143909839_143910067	0.17	RP11-190J23.1		19788	0.22
chr17_62032388_62032539	0.17	SCN4A	sodium channel, voltage-gated, type IV, alpha subunit	17815	0.11
chr19_54885476_54885627	0.17	LAIR1	leukocyte-associated immunoglobulin-like receptor 1	3386	0.14
chr2_220074664_220075050	0.17	ZFAND2B	zinc finger, AN1-type domain 2B	1677	0.16
chr1_44889322_44889516	0.17	RNF220	ring finger protein 220	293	0.91
chr2_10815795_10815988	0.17	NOL10	nucleolar protein 10	4075	0.21
chr7_29288155_29288306	0.17	AC004593.3		39644	0.16
chr8_96087280_96087459	0.17	MIR3150A	microRNA 3150a	1959	0.28
chr6_116784453_116784778	0.17	RP1-93H18.6		240	0.83
chr6_6637501_6637686	0.17	LY86-AS1	LY86 antisense RNA 1	14589	0.26
chr14_75152469_75152620	0.17	AREL1	apoptosis resistant E3 ubiquitin protein ligase 1	9626	0.15
chr5_78204185_78204336	0.17	ARSB	arylsulfatase B	77348	0.11
chr5_59560361_59560512	0.17	ENSG00000202017	.	39542	0.2
chr19_46179501_46179652	0.17	ENSG00000207773	.	1390	0.21
chr21_43845315_43845466	0.17	ENSG00000252619	.	7688	0.14
chr4_82421002_82421153	0.17	RASGEF1B	RasGEF domain family, member 1B	28008	0.26
chr1_45819749_45819900	0.17	ENSG00000238945	.	4596	0.17
chrX_22015726_22015877	0.17	PHEX	phosphate regulating endopeptidase homolog, X-linked	34758	0.17
chr5_148148648_148148804	0.17	ADRB2	adrenoceptor beta 2, surface	57430	0.14
chr19_46005187_46005379	0.16	PPM1N	protein phosphatase, Mg2+/Mn2+ dependent, 1N (putative)	2064	0.19
chr16_81787336_81787487	0.16	PLCG2	phospholipase C, gamma 2 (phosphatidylinositol-specific)	14709	0.27
chr10_114502069_114502220	0.16	RP11-25C19.3		64566	0.12
chr3_32447849_32448023	0.16	CMTM7	CKLF-like MARVEL transmembrane domain containing 7	14405	0.24
chr7_41506541_41506692	0.16	INHBA-AS1	INHBA antisense RNA 1	226898	0.02
chr20_2271241_2271392	0.16	TGM3	transglutaminase 3	5331	0.27
chr2_221996968_221997119	0.16	EPHA4	EPH receptor A4	370237	0.01
chr22_24525026_24525177	0.16	CABIN1	calcineurin binding protein 1	26705	0.14
chr2_173998078_173998369	0.16	MLTK	Mitogen-activated protein kinase kinase kinase MLT	42876	0.16
chr8_82030046_82030197	0.16	PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	5818	0.31
chr20_58653485_58653636	0.16	C20orf197	chromosome 20 open reading frame 197	22580	0.23
chr2_232164549_232164700	0.16	ARMC9	armadillo repeat containing 9	29379	0.17
chr6_5403263_5403414	0.16	FARS2	phenylalanyl-tRNA synthetase 2, mitochondrial	1437	0.53
chr22_22889208_22889359	0.16	PRAME	preferentially expressed antigen in melanoma	7320	0.07
chr10_99126345_99126553	0.16	RRP12	ribosomal RNA processing 12 homolog (S. cerevisiae)	24153	0.09
chr3_140732457_140732639	0.16	SPSB4	splA/ryanodine receptor domain and SOCS box containing 4	37696	0.16
chr5_66338060_66338433	0.16	MAST4	microtubule associated serine/threonine kinase family member 4	37763	0.19

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of MEIS3_TGIF2LX

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View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0032959	inositol trisphosphate biosynthetic process(GO:0032959)
0.1	0.2	GO:0035234	ectopic germ cell programmed cell death(GO:0035234)
0.0	0.1	GO:0045906	negative regulation of vasoconstriction(GO:0045906)
0.0	0.1	GO:0000101	sulfur amino acid transport(GO:0000101) L-cystine transport(GO:0015811)
0.0	0.2	GO:0031272	pseudopodium assembly(GO:0031269) regulation of pseudopodium assembly(GO:0031272) positive regulation of pseudopodium assembly(GO:0031274)
0.0	0.1	GO:0010193	response to ozone(GO:0010193)
0.0	0.1	GO:0002726	positive regulation of T cell cytokine production(GO:0002726)
0.0	0.1	GO:0031223	response to auditory stimulus(GO:0010996) auditory behavior(GO:0031223)
0.0	0.1	GO:0045654	positive regulation of megakaryocyte differentiation(GO:0045654) positive regulation of hematopoietic progenitor cell differentiation(GO:1901534)
0.0	0.1	GO:0014041	regulation of neuron maturation(GO:0014041) regulation of cell maturation(GO:1903429)
0.0	0.1	GO:0001675	acrosome assembly(GO:0001675)
0.0	0.2	GO:0015884	folic acid transport(GO:0015884)
0.0	0.1	GO:0043320	natural killer cell activation involved in immune response(GO:0002323) natural killer cell degranulation(GO:0043320)
0.0	0.1	GO:0006154	adenosine catabolic process(GO:0006154)
0.0	0.1	GO:0033622	integrin activation(GO:0033622)
0.0	0.1	GO:0051016	barbed-end actin filament capping(GO:0051016)
0.0	0.1	GO:0010886	positive regulation of cholesterol storage(GO:0010886)
0.0	0.1	GO:1903224	endodermal cell fate specification(GO:0001714) regulation of endodermal cell fate specification(GO:0042663) regulation of endodermal cell differentiation(GO:1903224)
0.0	0.0	GO:0045578	negative regulation of B cell differentiation(GO:0045578)
0.0	0.0	GO:0072194	kidney smooth muscle tissue development(GO:0072194)
0.0	0.1	GO:0046501	protoporphyrinogen IX metabolic process(GO:0046501)
0.0	0.1	GO:0060665	regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.0	0.1	GO:1901503	ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
0.0	0.0	GO:0033148	positive regulation of intracellular estrogen receptor signaling pathway(GO:0033148)
0.0	0.1	GO:0015705	iodide transport(GO:0015705)
0.0	0.2	GO:0051155	positive regulation of striated muscle cell differentiation(GO:0051155)
0.0	0.0	GO:0002025	vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure(GO:0002025)
0.0	0.1	GO:0007028	cytoplasm organization(GO:0007028)
0.0	0.1	GO:0006734	NADH metabolic process(GO:0006734)
0.0	0.0	GO:0030091	protein repair(GO:0030091)
0.0	0.1	GO:0035751	lysosomal lumen acidification(GO:0007042) regulation of lysosomal lumen pH(GO:0035751)
0.0	0.1	GO:0006432	phenylalanyl-tRNA aminoacylation(GO:0006432)
0.0	0.2	GO:0030851	granulocyte differentiation(GO:0030851)
0.0	0.1	GO:0060123	regulation of growth hormone secretion(GO:0060123)
0.0	0.3	GO:0051865	protein autoubiquitination(GO:0051865)
0.0	0.0	GO:0030538	embryonic genitalia morphogenesis(GO:0030538)
0.0	0.1	GO:0009912	auditory receptor cell fate commitment(GO:0009912) inner ear receptor cell fate commitment(GO:0060120)
0.0	0.0	GO:0032632	interleukin-3 production(GO:0032632)
0.0	0.0	GO:0046931	pore complex assembly(GO:0046931)
0.0	0.0	GO:0070340	detection of bacterial lipoprotein(GO:0042494) detection of bacterial lipopeptide(GO:0070340)
0.0	0.1	GO:0034204	lipid translocation(GO:0034204) phospholipid translocation(GO:0045332)
0.0	0.2	GO:0050732	negative regulation of peptidyl-tyrosine phosphorylation(GO:0050732)
0.0	0.1	GO:0032849	positive regulation of cellular pH reduction(GO:0032849)
0.0	0.1	GO:0045356	positive regulation of interferon-alpha biosynthetic process(GO:0045356)
0.0	0.0	GO:0045002	DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792) double-strand break repair via single-strand annealing(GO:0045002)
0.0	0.1	GO:0006610	ribosomal protein import into nucleus(GO:0006610)
0.0	0.1	GO:0060219	camera-type eye photoreceptor cell differentiation(GO:0060219)
0.0	0.0	GO:0008215	spermine metabolic process(GO:0008215)
0.0	0.0	GO:0015959	diadenosine polyphosphate metabolic process(GO:0015959)
0.0	0.0	GO:0044240	multicellular organism lipid catabolic process(GO:0044240)
0.0	0.1	GO:0098876	Golgi to plasma membrane transport(GO:0006893) vesicle-mediated transport to the plasma membrane(GO:0098876)
0.0	0.1	GO:0033197	response to vitamin E(GO:0033197)
0.0	0.1	GO:0035025	positive regulation of Rho protein signal transduction(GO:0035025)
0.0	0.0	GO:0043129	surfactant homeostasis(GO:0043129) chemical homeostasis within a tissue(GO:0048875)
0.0	0.0	GO:0040016	embryonic cleavage(GO:0040016)
0.0	0.1	GO:0001562	response to protozoan(GO:0001562)
0.0	0.0	GO:0019532	oxalate transport(GO:0019532)
0.0	0.0	GO:0052805	histidine catabolic process(GO:0006548) imidazole-containing compound catabolic process(GO:0052805)
0.0	0.1	GO:0034331	cell junction maintenance(GO:0034331) cell-cell junction maintenance(GO:0045217)
0.0	0.1	GO:0046874	quinolinate metabolic process(GO:0046874)
0.0	0.0	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II(GO:0019886)
0.0	0.0	GO:0009296	obsolete flagellum assembly(GO:0009296)
0.0	0.0	GO:0033194	response to hydroperoxide(GO:0033194)
0.0	0.0	GO:0032808	lacrimal gland development(GO:0032808)
0.0	0.0	GO:0097035	regulation of membrane lipid distribution(GO:0097035)

Gene overrepresentation in cellular component category:

Total log-likelihood	Term	Description
0.1	GO:0009331	glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.1	GO:0031265	CD95 death-inducing signaling complex(GO:0031265)
0.1	GO:0033268	node of Ranvier(GO:0033268)
0.1	GO:0005915	zonula adherens(GO:0005915)
0.0	GO:0071664	catenin-TCF7L2 complex(GO:0071664)
0.0	GO:0033150	cytoskeletal calyx(GO:0033150)
0.1	GO:0043190	ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.0	GO:0042629	mast cell granule(GO:0042629)
0.1	GO:0008290	F-actin capping protein complex(GO:0008290)
0.1	GO:0034362	low-density lipoprotein particle(GO:0034362)
0.1	GO:0031941	filamentous actin(GO:0031941)
0.1	GO:0005663	DNA replication factor C complex(GO:0005663)
0.0	GO:0008282	ATP-sensitive potassium channel complex(GO:0008282)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0001515	opioid peptide activity(GO:0001515)
0.0	0.2	GO:0008518	reduced folate carrier activity(GO:0008518)
0.0	0.1	GO:0015184	L-cystine transmembrane transporter activity(GO:0015184)
0.0	0.1	GO:0004367	glycerol-3-phosphate dehydrogenase [NAD+] activity(GO:0004367)
0.0	0.1	GO:0004185	serine-type carboxypeptidase activity(GO:0004185)
0.0	0.1	GO:0047756	chondroitin 4-sulfotransferase activity(GO:0047756)
0.0	0.1	GO:0008474	palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0	0.1	GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.0	0.1	GO:0001846	opsonin binding(GO:0001846)
0.0	0.1	GO:0052659	inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658) inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity(GO:0052659)
0.0	0.1	GO:0030023	extracellular matrix constituent conferring elasticity(GO:0030023) structural molecule activity conferring elasticity(GO:0097493)
0.0	0.1	GO:0031685	adenosine receptor binding(GO:0031685)
0.0	0.1	GO:0004849	uridine kinase activity(GO:0004849)
0.0	0.1	GO:0003953	NAD+ nucleosidase activity(GO:0003953)
0.0	0.1	GO:0001727	lipid kinase activity(GO:0001727)
0.0	0.0	GO:0070053	thrombospondin receptor activity(GO:0070053)
0.0	0.0	GO:0030881	beta-2-microglobulin binding(GO:0030881)
0.0	0.0	GO:0005412	glucose:sodium symporter activity(GO:0005412)
0.0	0.0	GO:0017060	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity(GO:0017060)
0.0	0.0	GO:0001099	basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.0	0.0	GO:0033743	peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.0	0.0	GO:0004939	beta-adrenergic receptor activity(GO:0004939)
0.0	0.1	GO:0045569	TRAIL binding(GO:0045569)
0.0	0.0	GO:0004803	transposase activity(GO:0004803)
0.0	0.2	GO:0004716	receptor signaling protein tyrosine kinase activity(GO:0004716)
0.0	0.1	GO:0008266	poly(U) RNA binding(GO:0008266)
0.0	0.0	GO:0004060	arylamine N-acetyltransferase activity(GO:0004060)
0.0	0.0	GO:0050693	LBD domain binding(GO:0050693)
0.0	0.1	GO:0008273	calcium, potassium:sodium antiporter activity(GO:0008273)
0.0	0.1	GO:0042285	UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285)
0.0	0.0	GO:0043175	RNA polymerase core enzyme binding(GO:0043175)
0.0	0.0	GO:0032450	maltose alpha-glucosidase activity(GO:0032450)
0.0	0.2	GO:0030169	low-density lipoprotein particle binding(GO:0030169)
0.0	0.0	GO:0048039	ubiquinone binding(GO:0048039)
0.0	0.1	GO:0004826	phenylalanine-tRNA ligase activity(GO:0004826)
0.0	0.0	GO:0004127	cytidylate kinase activity(GO:0004127)
0.0	0.1	GO:0016520	growth hormone-releasing hormone receptor activity(GO:0016520)
0.0	0.1	GO:0033170	DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0	0.3	GO:0019212	phosphatase inhibitor activity(GO:0019212)
0.0	0.0	GO:0019958	C-X-C chemokine binding(GO:0019958) interleukin-8 binding(GO:0019959)
0.0	0.0	GO:0050542	icosanoid binding(GO:0050542) fatty acid derivative binding(GO:1901567)
0.0	0.0	GO:0019788	NEDD8 transferase activity(GO:0019788)
0.0	0.1	GO:0005132	type I interferon receptor binding(GO:0005132)
0.0	0.0	GO:0030215	semaphorin receptor binding(GO:0030215)
0.0	0.1	GO:0051635	obsolete bacterial cell surface binding(GO:0051635)
0.0	0.0	GO:0043533	inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.0	0.0	GO:0016286	small conductance calcium-activated potassium channel activity(GO:0016286)
0.0	0.0	GO:0047631	ADP-ribose diphosphatase activity(GO:0047631)
0.0	0.0	GO:0090599	alpha-glucosidase activity(GO:0090599)
0.0	0.0	GO:0008821	crossover junction endodeoxyribonuclease activity(GO:0008821)
0.0	0.0	GO:0015272	ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.0	0.0	GO:0030368	interleukin-17 receptor activity(GO:0030368)
0.0	0.2	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0	0.1	GO:0042895	antibiotic transporter activity(GO:0042895)
0.0	0.1	GO:0008199	ferric iron binding(GO:0008199)
0.0	0.1	GO:0019864	IgG binding(GO:0019864)
0.0	0.0	GO:0017128	phospholipid scramblase activity(GO:0017128)
0.0	0.0	GO:0071723	lipopeptide binding(GO:0071723)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.0	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
0.0	PID PI3KCI AKT PATHWAY	Class I PI3K signaling events mediated by Akt
0.4	SIG PIP3 SIGNALING IN B LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes
0.1	SA B CELL RECEPTOR COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.1	PID TRAIL PATHWAY	TRAIL signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.0	REACTOME DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR	Genes involved in Downstream Signaling Events Of B Cell Receptor (BCR)
0.4	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.1	REACTOME NOD1 2 SIGNALING PATHWAY	Genes involved in NOD1/2 Signaling Pathway
0.2	REACTOME REGULATION OF KIT SIGNALING	Genes involved in Regulation of KIT signaling
0.0	REACTOME DAG AND IP3 SIGNALING	Genes involved in DAG and IP3 signaling
0.2	REACTOME ERK MAPK TARGETS	Genes involved in ERK/MAPK targets
0.1	REACTOME P2Y RECEPTORS	Genes involved in P2Y receptors