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ENCODE: H3K4me1 ChIP-Seq of primary human cells

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Results for MLX_USF2_USF1_PAX2

Z-value: 1.54

Motif logo

Transcription factors associated with MLX_USF2_USF1_PAX2

Gene Symbol	Gene ID	Gene Info
MLX Ensembl NCBI GeneCards UniProt	ENSG00000108788.7	MAX dimerization protein MLX
USF2 Ensembl NCBI GeneCards UniProt	ENSG00000105698.11	upstream transcription factor 2, c-fos interacting
USF1 Ensembl NCBI GeneCards UniProt	ENSG00000158773.10	upstream transcription factor 1
PAX2 Ensembl NCBI GeneCards UniProt	ENSG00000075891.17	paired box 2

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
chr17_40718643_40718957	MLX	286	0.777475	0.84	5.0e-03	Click!
chr17_40720881_40721032	MLX	1864	0.155195	0.36	3.4e-01	Click!
chr17_40721119_40721270	MLX	2102	0.139331	-0.29	4.4e-01	Click!
chr17_40718230_40718434	MLX	754	0.404256	0.16	6.9e-01	Click!
chr17_40718061_40718212	MLX	950	0.315505	0.16	6.9e-01	Click!
chr10_102506499_102506650	PAX2	589	0.809371	-0.79	1.2e-02	Click!
chr10_102483469_102483620	PAX2	21924	0.218544	-0.69	3.9e-02	Click!
chr10_102415499_102415657	PAX2	89890	0.070088	-0.64	6.6e-02	Click!
chr10_102483883_102484034	PAX2	21510	0.219601	-0.62	7.8e-02	Click!
chr10_102490708_102490881	PAX2	14674	0.236070	0.60	9.0e-02	Click!
chr1_161011886_161012093	USF1	478	0.629110	-0.71	3.1e-02	Click!
chr1_161014793_161014944	USF1	137	0.908696	0.68	4.2e-02	Click!
chr1_161011189_161011380	USF1	227	0.844346	-0.66	5.2e-02	Click!
chr1_161018945_161019096	USF1	3253	0.112097	0.59	9.7e-02	Click!
chr1_161014996_161015163	USF1	348	0.745088	0.53	1.4e-01	Click!
chr19_35757754_35758158	USF2	1925	0.161815	0.64	6.5e-02	Click!
chr19_35756749_35756900	USF2	3057	0.112737	0.62	7.5e-02	Click!
chr19_35762491_35762693	USF2	688	0.471168	0.60	8.5e-02	Click!
chr19_35760711_35760932	USF2	345	0.743449	0.56	1.1e-01	Click!
chr19_35760287_35760438	USF2	344	0.744233	0.56	1.2e-01	Click!

Activity of the MLX_USF2_USF1_PAX2 motif across conditions

Conditions sorted by the z-value of the MLX_USF2_USF1_PAX2 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr3_13549513_13549664	1.09	FBLN2	fibulin 2	24236	0.16
chr5_14174403_14174686	0.95	TRIO	trio Rho guanine nucleotide exchange factor	9363	0.32
chr21_43953040_43953239	0.92	SLC37A1	solute carrier family 37 (glucose-6-phosphate transporter), member 1	18505	0.13
chrX_153745295_153745474	0.92	FAM3A	family with sequence similarity 3, member A	818	0.33
chr6_3139599_3139904	0.90	BPHL	biphenyl hydrolase-like (serine hydrolase)	908	0.5
chr9_137537253_137537404	0.88	COL5A1	collagen, type V, alpha 1	3708	0.25
chr15_77284673_77284824	0.80	PSTPIP1	proline-serine-threonine phosphatase interacting protein 1	952	0.57
chr13_40105934_40106139	0.79	LHFP	lipoma HMGIC fusion partner	71272	0.11
chr6_16681395_16681795	0.77	RP1-151F17.1		79774	0.1
chr3_125322024_125322175	0.75	OSBPL11	oxysterol binding protein-like 11	8165	0.22
chr3_45070851_45071181	0.71	CLEC3B	C-type lectin domain family 3, member B	606	0.71
chr13_44730147_44730391	0.71	SMIM2-IT1	SMIM2 intronic transcript 1 (non-protein coding)	2089	0.32
chr10_70480665_70480816	0.69	CCAR1	cell division cycle and apoptosis regulator 1	29	0.96
chr3_168823031_168823291	0.66	MECOM	MDS1 and EVI1 complex locus	22661	0.28
chr20_1852587_1852738	0.65	SIRPA	signal-regulatory protein alpha	22492	0.22
chr2_232229722_232230070	0.65	ENSG00000263641	.	2477	0.26
chr1_202558646_202558797	0.65	RP11-569A11.1		14675	0.2
chr1_27855366_27855678	0.64	RP1-159A19.4		3206	0.23
chr15_76050777_76050928	0.62	ENSG00000261043	.	3804	0.12
chr14_36538512_36538663	0.62	ENSG00000212071	.	127187	0.05
chr3_72378625_72378776	0.61	ENSG00000212070	.	67121	0.13
chr1_95328697_95328848	0.60	SLC44A3	solute carrier family 44, member 3	4115	0.22
chr4_164253447_164254003	0.60	NPY1R	neuropeptide Y receptor Y1	23	0.98
chr19_35939108_35939372	0.59	FFAR2	free fatty acid receptor 2	37	0.96
chr4_87935620_87935975	0.58	AFF1	AF4/FMR2 family, member 1	7376	0.29
chr16_73104328_73104761	0.57	ZFHX3	zinc finger homeobox 3	10947	0.24
chr2_223574012_223574225	0.57	ENSG00000238852	.	11399	0.21
chr10_102124571_102124984	0.57	SCD	stearoyl-CoA desaturase (delta-9-desaturase)	17896	0.13
chr2_177825630_177825781	0.57	ENSG00000206866	.	30887	0.22
chr6_150326385_150326536	0.56	RAET1K	retinoic acid early transcript 1K pseudogene	167	0.94
chr3_194592690_194592936	0.52	FAM43A	family with sequence similarity 43, member A	186191	0.02
chr14_104018069_104018220	0.51	ENSG00000252469	.	1462	0.17
chr19_7897788_7897939	0.50	EVI5L	ecotropic viral integration site 5-like	2744	0.16
chr17_3545041_3545192	0.50	CTNS	cystinosin, lysosomal cystine transporter	1675	0.21
chr11_9778103_9778254	0.49	SBF2-AS1	SBF2 antisense RNA 1	1661	0.36
chr7_101524016_101524398	0.49	CTA-339C12.1		56198	0.12
chr22_38597727_38597878	0.49	MAFF	v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F	87	0.95
chr2_47313454_47313781	0.48	AC073283.7		18656	0.18
chr4_3441770_3441921	0.48	HGFAC	HGF activator	1769	0.34
chr11_12138065_12138216	0.48	MICAL2	microtubule associated monooxygenase, calponin and LIM domain containing 2	103	0.98
chr7_2393665_2393816	0.47	EIF3B	eukaryotic translation initiation factor 3, subunit B	19	0.73
chr9_80480359_80480547	0.47	GNAQ	guanine nucleotide binding protein (G protein), q polypeptide	42538	0.21
chr1_23710189_23710340	0.47	TCEA3	transcription elongation factor A (SII), 3	3648	0.16
chr20_10765189_10765340	0.46	JAG1	jagged 1	110570	0.07
chr19_15667107_15667284	0.46	CYP4F23P	cytochrome P450, family 4, subfamily F, polypeptide 23, pseudogene	7690	0.17
chr1_59602387_59602647	0.46	FGGY	FGGY carbohydrate kinase domain containing	159793	0.04
chr22_30195521_30195699	0.46	ASCC2	activating signal cointegrator 1 complex subunit 2	2481	0.22
chr6_37961556_37961707	0.45	ZFAND3	zinc finger, AN1-type domain 3	63896	0.12
chr5_14261499_14261650	0.45	TRIO	trio Rho guanine nucleotide exchange factor	29512	0.26
chr16_85549609_85549893	0.45	ENSG00000264203	.	74653	0.09
chrX_119683463_119683614	0.44	ENSG00000272179	.	5368	0.2
chr4_89978365_89978621	0.44	FAM13A	family with sequence similarity 13, member A	3	0.99
chr2_66748499_66748650	0.44	MEIS1	Meis homeobox 1	12515	0.25
chr12_18535849_18536000	0.44	PIK3C2G	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma	100946	0.09
chr19_15236377_15236528	0.44	ILVBL	ilvB (bacterial acetolactate synthase)-like	18	0.95
chr3_40822071_40822222	0.44	ZNF621	zinc finger protein 621	255239	0.02
chr1_53601169_53601320	0.44	SLC1A7	solute carrier family 1 (glutamate transporter), member 7	7005	0.14
chr22_19792678_19792829	0.43	TBX1	T-box 1	48527	0.1
chr6_5026598_5026771	0.43	ENSG00000252419	.	19651	0.19
chr1_154908750_154909040	0.43	PMVK	phosphomevalonate kinase	572	0.57
chr12_48147567_48147718	0.43	SLC48A1	solute carrier family 48 (heme transporter), member 1	57	0.96
chr1_8965801_8965952	0.42	ENSG00000201725	.	22284	0.12
chr12_11897037_11897481	0.42	ETV6	ets variant 6	8176	0.3
chr6_157469967_157470240	0.42	ARID1B	AT rich interactive domain 1B (SWI1-like)	58	0.98
chr10_115821373_115821605	0.41	ADRB1	adrenoceptor beta 1	17683	0.2
chr2_101507765_101507916	0.41	NPAS2	neuronal PAS domain protein 2	33768	0.17
chr19_33772501_33772652	0.41	CTD-2540B15.11		18264	0.12
chr8_56832033_56832524	0.41	ENSG00000216204	.	10758	0.14
chr10_30842903_30843087	0.40	ENSG00000239744	.	1838	0.44
chr9_81760534_81760685	0.40	TLE4	transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)	426079	0.01
chr17_15846247_15846498	0.40	ADORA2B	adenosine A2b receptor	1859	0.35
chr17_80454949_80455167	0.40	NARF-IT1	NARF intronic transcript 1 (non-protein coding)	15084	0.09
chr8_67280871_67281022	0.40	RRS1	RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)	60317	0.12
chr5_169308444_169308734	0.40	FAM196B	family with sequence similarity 196, member B	99155	0.07
chr17_65356219_65356565	0.40	PSMD12	proteasome (prosome, macropain) 26S subunit, non-ATPase, 12	6329	0.16
chr16_8623102_8623253	0.40	TMEM114	transmembrane protein 114	951	0.68
chr9_114987375_114987526	0.40	ENSG00000242256	.	17669	0.15
chr17_5014893_5015044	0.39	ZNF232	zinc finger protein 232	168	0.53
chr10_81160624_81160775	0.39	RP11-342M3.5		18615	0.19
chr3_172312501_172312712	0.39	AC007919.2	HCG1787166; PRO1163; Uncharacterized protein	48877	0.13
chr12_69007841_69008681	0.39	RAP1B	RAP1B, member of RAS oncogene family	3456	0.26
chr7_41187429_41187580	0.39	AC005160.3		372347	0.01
chr9_21552433_21552584	0.39	MIR31HG	MIR31 host gene (non-protein coding)	7160	0.18
chr1_241696314_241696465	0.39	KMO	kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)	684	0.73
chr4_37763878_37764029	0.39	ENSG00000207075	.	62329	0.11
chr2_60326351_60326534	0.38	ENSG00000200807	.	285298	0.01
chr5_149978721_149978872	0.38	SYNPO	synaptopodin	1846	0.3
chr6_113786206_113786410	0.38	ENSG00000222677	.	49881	0.18
chr17_80561019_80561170	0.38	RP13-638C3.4		960	0.39
chr14_103453216_103453367	0.38	CDC42BPB	CDC42 binding protein kinase beta (DMPK-like)	18422	0.17
chr16_2556960_2557241	0.38	ATP6V0C	ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c	6771	0.06
chr22_39637061_39637212	0.37	PDGFB	platelet-derived growth factor beta polypeptide	1	0.97
chr5_52328001_52328285	0.37	CTD-2175A23.1		42035	0.14
chr14_105216209_105216503	0.37	SIVA1	SIVA1, apoptosis-inducing factor	3081	0.16
chr21_45232124_45232332	0.36	AP001053.11		220	0.93
chr16_839632_839783	0.36	CHTF18	CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae)	394	0.62
chr2_159996739_159997187	0.36	ENSG00000202029	.	113309	0.06
chr5_171380911_171381062	0.36	FBXW11	F-box and WD repeat domain containing 11	23774	0.23
chr21_43149115_43149266	0.36	AP001615.9		10343	0.18
chr9_139590982_139591211	0.36	ENSG00000221693	.	2508	0.12
chr10_133806127_133806278	0.36	BNIP3	BCL2/adenovirus E1B 19kDa interacting protein 3	10767	0.25
chr2_112763039_112763349	0.36	MERTK	c-mer proto-oncogene tyrosine kinase	13796	0.22
chr10_70093169_70093554	0.36	PBLD	phenazine biosynthesis-like protein domain containing	555	0.68
chr16_80755255_80755539	0.36	CTD-2055G21.1		14860	0.21
chr1_54838230_54838447	0.36	SSBP3	single stranded DNA binding protein 3	32839	0.17
chr8_33185297_33185548	0.35	ENSG00000252735	.	10963	0.27
chr20_5700865_5701016	0.35	C20orf196	chromosome 20 open reading frame 196	30099	0.21
chr22_35776953_35777104	0.35	HMOX1	heme oxygenase (decycling) 1	200	0.94
chr17_25659543_25659861	0.35	WSB1	WD repeat and SOCS box containing 1	38330	0.16
chr11_61809719_61809884	0.35	AP003733.1	Uncharacterized protein; cDNA FLJ36460 fis, clone THYMU2014801	74348	0.07
chr19_13171670_13171936	0.35	AC007787.2		10385	0.11
chr3_4778144_4778623	0.35	ENSG00000239126	.	142003	0.04
chr22_43187176_43187327	0.34	ENSG00000200448	.	28286	0.16
chr4_151223828_151223979	0.34	LRBA	LPS-responsive vesicle trafficking, beach and anchor containing	40	0.99
chr2_103104657_103104827	0.34	SLC9A4	solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4	14980	0.18
chr19_5681037_5681411	0.34	RPL36	ribosomal protein L36	31	0.46
chr5_14153391_14153542	0.34	TRIO	trio Rho guanine nucleotide exchange factor	9637	0.32
chr8_145692200_145692386	0.34	KIFC2	kinesin family member C2	645	0.36
chr2_12013641_12013798	0.34	ENSG00000265172	.	36607	0.17
chr3_170626507_170626658	0.33	EIF5A2	eukaryotic translation initiation factor 5A2	100	0.97
chr3_196758334_196758485	0.33	MFI2	antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5	1722	0.35
chr5_56800275_56800426	0.33	ACTBL2	actin, beta-like 2	21714	0.21
chr5_71475626_71475777	0.33	MAP1B	microtubule-associated protein 1B	246	0.94
chr8_28558220_28558688	0.33	EXTL3-AS1	EXTL3 antisense RNA 1	316	0.56
chr17_74526963_74527181	0.33	CYGB	cytoglobin	1075	0.29
chr16_72159132_72159326	0.33	PMFBP1	polyamine modulated factor 1 binding protein 1	477	0.76
chr2_33355278_33355578	0.33	LTBP1	latent transforming growth factor beta binding protein 1	4045	0.34
chr14_59721391_59721542	0.33	DAAM1	dishevelled associated activator of morphogenesis 1	8707	0.3
chr15_35598915_35599148	0.33	ENSG00000265102	.	65534	0.14
chr15_43545776_43545927	0.33	ENSG00000202211	.	5973	0.13
chr3_63611225_63611376	0.33	SNTN	sentan, cilia apical structure protein	27044	0.2
chr8_68256392_68257141	0.33	ARFGEF1	ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)	854	0.75
chr9_84646672_84646823	0.33	SPATA31D1	SPATA31 subfamily D, member 1	43060	0.17
chr3_148184411_148184664	0.33	AGTR1	angiotensin II receptor, type 1	231034	0.02
chr9_90094686_90094877	0.32	DAPK1	death-associated protein kinase 1	17362	0.26
chr4_57911593_57911744	0.32	ENSG00000251703	.	42810	0.11
chr11_10696838_10697077	0.32	MRVI1	murine retrovirus integration site 1 homolog	18104	0.17
chr5_416066_416217	0.32	AHRR	aryl-hydrocarbon receptor repressor	4894	0.17
chr5_54179191_54179535	0.32	ENSG00000221073	.	30587	0.19
chr3_13388227_13388378	0.32	NUP210	nucleoporin 210kDa	73507	0.11
chr19_10811913_10812092	0.32	QTRT1	queuine tRNA-ribosyltransferase 1	125	0.94
chr7_104603855_104604006	0.32	ENSG00000251911	.	7804	0.19
chr3_195634831_195635065	0.32	TNK2-AS1	TNK2 antisense RNA 1	1	0.94
chr15_71571317_71571468	0.32	RP11-592N21.2		63271	0.13
chr5_75810430_75810581	0.31	IQGAP2	IQ motif containing GTPase activating protein 2	32729	0.2
chr2_129271124_129271275	0.31	ENSG00000238379	.	68427	0.13
chr16_85116068_85116219	0.31	KIAA0513	KIAA0513	4118	0.25
chr19_52270463_52270746	0.31	FPR2	formyl peptide receptor 2	1027	0.41
chr11_70048877_70049168	0.31	FADD	Fas (TNFRSF6)-associated via death domain	247	0.89
chr7_150125120_150125271	0.31	GIMAP8	GTPase, IMAP family member 8	22523	0.13
chr3_158519751_158519902	0.31	MFSD1	major facilitator superfamily domain containing 1	54	0.56
chr17_38170774_38170925	0.31	CSF3	colony stimulating factor 3 (granulocyte)	765	0.5
chr5_74867541_74867832	0.31	POLK	polymerase (DNA directed) kappa	24838	0.14
chr1_10961492_10961643	0.31	C1orf127	chromosome 1 open reading frame 127	46360	0.12
chr3_25823149_25824090	0.31	NGLY1	N-glycanase 1	744	0.48
chr19_41193716_41193867	0.31	NUMBL	numb homolog (Drosophila)-like	1706	0.25
chr4_11108422_11108651	0.31	ENSG00000207716	.	261915	0.02
chr6_15897284_15897435	0.31	MYLIP	myosin regulatory light chain interacting protein	231997	0.02
chr1_1240214_1240383	0.30	ACAP3	ArfGAP with coiled-coil, ankyrin repeat and PH domains 3	2971	0.09
chr11_63949086_63949357	0.30	STIP1	stress-induced-phosphoprotein 1	3523	0.11
chr7_14031116_14031563	0.30	ETV1	ets variant 1	289	0.94
chr18_9700600_9700751	0.30	RAB31	RAB31, member RAS oncogene family	7487	0.23
chr12_28343189_28343340	0.30	RP11-967K21.1		35	0.57
chr1_204412312_204412463	0.30	PIK3C2B	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta	24087	0.15
chr2_196977219_196977406	0.30	RP11-347P5.1		38675	0.15
chr3_60541525_60541676	0.30	FHIT	fragile histidine triad	18905	0.3
chr9_89772699_89772850	0.30	C9orf170	chromosome 9 open reading frame 170	9215	0.3
chr1_41235374_41235525	0.30	ENSG00000207962	.	12493	0.12
chr1_86036309_86036460	0.30	DDAH1	dimethylarginine dimethylaminohydrolase 1	7549	0.2
chr2_40266109_40266315	0.29	SLC8A1-AS1	SLC8A1 antisense RNA 1	3278	0.4
chr14_22898142_22898379	0.29	ENSG00000251002	.	3459	0.15
chr6_52376693_52376847	0.29	TRAM2	translocation associated membrane protein 2	64943	0.11
chr7_79081591_79081742	0.29	ENSG00000234456	.	532	0.7
chr1_200329291_200329593	0.29	ZNF281	zinc finger protein 281	49678	0.18
chr16_2133414_2133565	0.29	TSC2	tuberous sclerosis 2	298	0.71
chr20_47299074_47299247	0.29	ENSG00000251876	.	56825	0.16
chr10_26845646_26845984	0.29	ENSG00000199733	.	47297	0.17
chr21_43342071_43342250	0.29	C2CD2	C2 calcium-dependent domain containing 2	4639	0.19
chr17_26312086_26312243	0.29	ENSG00000251818	.	33632	0.13
chr3_187633047_187633241	0.28	BCL6	B-cell CLL/lymphoma 6	169629	0.03
chr16_57411779_57412024	0.28	CX3CL1	chemokine (C-X3-C motif) ligand 1	1017	0.45
chr17_46688135_46688867	0.28	HOXB7	homeobox B7	122	0.89
chr20_31126869_31127034	0.28	C20orf112	chromosome 20 open reading frame 112	2751	0.24
chr17_37356823_37356974	0.28	RPL19	ribosomal protein L19	300	0.84
chr2_43173895_43174110	0.28	ENSG00000207087	.	144630	0.04
chr17_80175257_80175581	0.28	RP13-516M14.2		3316	0.13
chr3_38657996_38658147	0.28	SCN5A	sodium channel, voltage-gated, type V, alpha subunit	16736	0.23
chr6_35393359_35394053	0.28	FANCE	Fanconi anemia, complementation group E	26432	0.15
chr10_13569426_13569628	0.28	RP11-214D15.2		989	0.36
chr1_112282155_112282306	0.28	FAM212B	family with sequence similarity 212, member B	184	0.56
chr2_243017380_243017531	0.28	RP11-341N2.1		13153	0.21
chr3_8890314_8890465	0.27	RAD18	RAD18 homolog (S. cerevisiae)	53693	0.11
chr8_18953240_18953562	0.27	PSD3	pleckstrin and Sec7 domain containing 3	11161	0.29
chr1_32184044_32184195	0.27	COL16A1	collagen, type XVI, alpha 1	14199	0.13
chr4_109909097_109909248	0.27	COL25A1	collagen, type XXV, alpha 1	163797	0.04
chr20_5485270_5485421	0.27	RP5-1022P6.5		28929	0.21
chr16_55530572_55531230	0.27	MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	8327	0.22
chr9_124582461_124582612	0.27	RP11-244O19.1		805	0.74
chr1_178027303_178027468	0.27	RASAL2	RAS protein activator like 2	35479	0.22
chr8_85095605_85095756	0.27	RALYL	RALY RNA binding protein-like	89	0.99

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of MLX_USF2_USF1_PAX2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:1900116	sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.1	0.3	GO:0045905	translational frameshifting(GO:0006452) positive regulation of translational elongation(GO:0045901) positive regulation of translational termination(GO:0045905)
0.1	0.3	GO:0043619	regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0043619)
0.1	0.6	GO:0051481	negative regulation of cytosolic calcium ion concentration(GO:0051481)
0.1	0.3	GO:0072239	metanephric glomerulus development(GO:0072224) metanephric glomerulus vasculature development(GO:0072239)
0.1	0.3	GO:0045112	integrin biosynthetic process(GO:0045112)
0.1	0.3	GO:0014012	peripheral nervous system axon regeneration(GO:0014012)
0.1	0.3	GO:0072201	negative regulation of mesenchymal cell proliferation(GO:0072201)
0.1	0.2	GO:0010701	positive regulation of norepinephrine secretion(GO:0010701)
0.1	0.3	GO:0019441	tryptophan catabolic process to kynurenine(GO:0019441)
0.1	0.2	GO:0003078	obsolete regulation of natriuresis(GO:0003078)
0.1	0.5	GO:0007185	transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.1	0.2	GO:0044240	multicellular organism lipid catabolic process(GO:0044240)
0.1	0.2	GO:0032467	positive regulation of cytokinesis(GO:0032467)
0.1	0.3	GO:0048755	branching morphogenesis of a nerve(GO:0048755)
0.1	0.2	GO:0048311	mitochondrion distribution(GO:0048311)
0.1	0.2	GO:0055098	response to low-density lipoprotein particle(GO:0055098)
0.1	0.2	GO:0010757	negative regulation of plasminogen activation(GO:0010757)
0.1	0.2	GO:0014067	negative regulation of phosphatidylinositol 3-kinase signaling(GO:0014067)
0.1	0.2	GO:0060528	secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.1	0.5	GO:0007567	parturition(GO:0007567)
0.1	0.2	GO:0032959	inositol trisphosphate biosynthetic process(GO:0032959)
0.1	0.2	GO:0010193	response to ozone(GO:0010193)
0.1	0.1	GO:0048520	positive regulation of behavior(GO:0048520)
0.1	0.2	GO:0009448	gamma-aminobutyric acid metabolic process(GO:0009448)
0.0	0.0	GO:0002125	maternal aggressive behavior(GO:0002125) obsolete positive regulation of natriuresis(GO:0003079)
0.0	0.1	GO:0045198	establishment of epithelial cell apical/basal polarity(GO:0045198)
0.0	0.0	GO:0000255	allantoin metabolic process(GO:0000255) creatinine metabolic process(GO:0046449) cellular lactam metabolic process(GO:0072338)
0.0	0.2	GO:0018101	protein citrullination(GO:0018101)
0.0	0.1	GO:0021798	forebrain dorsal/ventral pattern formation(GO:0021798)
0.0	0.4	GO:0019369	arachidonic acid metabolic process(GO:0019369)
0.0	0.1	GO:0000966	RNA 5'-end processing(GO:0000966)
0.0	0.2	GO:0048096	chromatin-mediated maintenance of transcription(GO:0048096)
0.0	0.2	GO:0007028	cytoplasm organization(GO:0007028)
0.0	0.3	GO:0015871	choline transport(GO:0015871)
0.0	0.2	GO:0060666	dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.0	0.0	GO:0046951	ketone body biosynthetic process(GO:0046951)
0.0	0.1	GO:0031340	positive regulation of vesicle fusion(GO:0031340)
0.0	0.0	GO:0048541	Peyer's patch development(GO:0048541)
0.0	0.1	GO:0007221	positive regulation of transcription of Notch receptor target(GO:0007221)
0.0	0.1	GO:0060013	righting reflex(GO:0060013)
0.0	0.1	GO:0032957	inositol trisphosphate metabolic process(GO:0032957)
0.0	0.2	GO:0000394	RNA splicing, via endonucleolytic cleavage and ligation(GO:0000394) tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.0	0.1	GO:0045793	positive regulation of cell size(GO:0045793)
0.0	0.2	GO:0000729	DNA double-strand break processing(GO:0000729)
0.0	0.1	GO:0071318	cellular response to ATP(GO:0071318)
0.0	0.4	GO:0007020	microtubule nucleation(GO:0007020)
0.0	0.2	GO:0006516	glycoprotein catabolic process(GO:0006516)
0.0	0.1	GO:0006663	platelet activating factor biosynthetic process(GO:0006663)
0.0	0.1	GO:0060999	positive regulation of dendritic spine development(GO:0060999)
0.0	0.2	GO:0045662	negative regulation of myoblast differentiation(GO:0045662)
0.0	0.1	GO:0050923	regulation of negative chemotaxis(GO:0050923)
0.0	0.1	GO:0000101	sulfur amino acid transport(GO:0000101) L-cystine transport(GO:0015811)
0.0	0.1	GO:0060083	smooth muscle contraction involved in micturition(GO:0060083)
0.0	0.1	GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
0.0	0.0	GO:0003308	negative regulation of Wnt signaling pathway involved in heart development(GO:0003308)
0.0	0.1	GO:0015691	cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
0.0	0.0	GO:0042118	endothelial cell activation(GO:0042118)
0.0	0.1	GO:0051176	positive regulation of sulfur metabolic process(GO:0051176)
0.0	0.1	GO:0071436	sodium ion export(GO:0071436)
0.0	0.2	GO:0015937	coenzyme A biosynthetic process(GO:0015937)
0.0	0.2	GO:0071425	hematopoietic stem cell proliferation(GO:0071425)
0.0	0.0	GO:0060433	bronchus development(GO:0060433)
0.0	0.2	GO:0030388	fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0	0.1	GO:0009048	dosage compensation by inactivation of X chromosome(GO:0009048)
0.0	0.1	GO:2000114	regulation of establishment of cell polarity(GO:2000114)
0.0	0.1	GO:0015959	diadenosine polyphosphate metabolic process(GO:0015959)
0.0	0.1	GO:0060831	smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:0060831)
0.0	0.1	GO:0072112	renal filtration cell differentiation(GO:0061318) glomerular epithelium development(GO:0072010) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.0	0.1	GO:0060136	embryonic process involved in female pregnancy(GO:0060136)
0.0	0.1	GO:0051790	short-chain fatty acid biosynthetic process(GO:0051790)
0.0	0.1	GO:0006883	cellular sodium ion homeostasis(GO:0006883)
0.0	0.1	GO:0018243	protein O-linked glycosylation via serine(GO:0018242) protein O-linked glycosylation via threonine(GO:0018243)
0.0	0.1	GO:0032488	Cdc42 protein signal transduction(GO:0032488)
0.0	0.2	GO:0070265	necrotic cell death(GO:0070265)
0.0	0.1	GO:0070141	response to UV-A(GO:0070141)
0.0	0.1	GO:0030917	midbrain-hindbrain boundary development(GO:0030917)
0.0	0.3	GO:0007016	cytoskeletal anchoring at plasma membrane(GO:0007016)
0.0	0.1	GO:0034626	fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0	0.1	GO:0071731	response to nitric oxide(GO:0071731)
0.0	0.1	GO:0033004	negative regulation of mast cell activation(GO:0033004)
0.0	0.1	GO:0010842	retina layer formation(GO:0010842)
0.0	0.1	GO:0006927	obsolete transformed cell apoptotic process(GO:0006927)
0.0	0.1	GO:0070427	nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427)
0.0	0.1	GO:0034638	phosphatidylcholine catabolic process(GO:0034638)
0.0	0.1	GO:0071800	podosome assembly(GO:0071800)
0.0	0.1	GO:0045080	positive regulation of chemokine biosynthetic process(GO:0045080)
0.0	0.2	GO:0010824	regulation of centrosome duplication(GO:0010824)
0.0	0.1	GO:0006565	L-serine catabolic process(GO:0006565)
0.0	0.1	GO:0030579	ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0	0.1	GO:0001996	positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996)
0.0	0.1	GO:0009249	protein lipoylation(GO:0009249)
0.0	0.1	GO:0030948	negative regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030948)
0.0	0.1	GO:0042753	positive regulation of circadian rhythm(GO:0042753)
0.0	0.2	GO:0044341	sodium-dependent phosphate transport(GO:0044341)
0.0	0.1	GO:0090073	positive regulation of protein homodimerization activity(GO:0090073)
0.0	0.1	GO:0006477	protein sulfation(GO:0006477)
0.0	0.1	GO:0043569	negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.0	0.1	GO:0060052	neurofilament cytoskeleton organization(GO:0060052)
0.0	0.1	GO:0045647	negative regulation of erythrocyte differentiation(GO:0045647)
0.0	0.1	GO:0009103	lipopolysaccharide biosynthetic process(GO:0009103)
0.0	0.1	GO:0009756	carbohydrate mediated signaling(GO:0009756)
0.0	0.0	GO:2000008	regulation of protein localization to cell surface(GO:2000008)
0.0	0.1	GO:0060907	positive regulation of macrophage cytokine production(GO:0060907)
0.0	0.0	GO:2000542	negative regulation of gastrulation(GO:2000542)
0.0	0.1	GO:0060754	mast cell chemotaxis(GO:0002551) regulation of mast cell chemotaxis(GO:0060753) positive regulation of mast cell chemotaxis(GO:0060754) mast cell migration(GO:0097531)
0.0	0.1	GO:0071364	cellular response to epidermal growth factor stimulus(GO:0071364)
0.0	0.1	GO:0071680	response to indole-3-methanol(GO:0071680) cellular response to indole-3-methanol(GO:0071681)
0.0	0.1	GO:0060029	convergent extension involved in organogenesis(GO:0060029)
0.0	0.1	GO:0006991	response to sterol depletion(GO:0006991)
0.0	0.1	GO:0034695	response to prostaglandin E(GO:0034695)
0.0	0.1	GO:0010890	positive regulation of sequestering of triglyceride(GO:0010890)
0.0	0.3	GO:0032012	regulation of ARF protein signal transduction(GO:0032012)
0.0	0.1	GO:0006931	substrate-dependent cell migration, cell attachment to substrate(GO:0006931)
0.0	0.1	GO:0061299	retina vasculature development in camera-type eye(GO:0061298) retina vasculature morphogenesis in camera-type eye(GO:0061299)
0.0	0.1	GO:0070050	neuron cellular homeostasis(GO:0070050)
0.0	0.1	GO:0014049	positive regulation of glutamate secretion(GO:0014049)
0.0	0.1	GO:0001833	inner cell mass cell proliferation(GO:0001833)
0.0	0.1	GO:0060710	chorio-allantoic fusion(GO:0060710)
0.0	0.0	GO:0021892	cerebral cortex GABAergic interneuron differentiation(GO:0021892)
0.0	0.1	GO:0022617	extracellular matrix disassembly(GO:0022617)
0.0	0.0	GO:0002538	arachidonic acid metabolite production involved in inflammatory response(GO:0002538) leukotriene production involved in inflammatory response(GO:0002540)
0.0	0.0	GO:0002238	response to molecule of fungal origin(GO:0002238)
0.0	0.1	GO:0032914	positive regulation of transforming growth factor beta1 production(GO:0032914)
0.0	0.0	GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway(GO:0010803)
0.0	0.2	GO:0007158	neuron cell-cell adhesion(GO:0007158)
0.0	0.1	GO:2000757	negative regulation of histone acetylation(GO:0035067) negative regulation of protein acetylation(GO:1901984) negative regulation of peptidyl-lysine acetylation(GO:2000757)
0.0	0.0	GO:1903332	regulation of protein folding(GO:1903332)
0.0	0.1	GO:0043320	natural killer cell activation involved in immune response(GO:0002323) natural killer cell degranulation(GO:0043320)
0.0	0.1	GO:0010288	response to lead ion(GO:0010288)
0.0	0.2	GO:0033631	cell-cell adhesion mediated by integrin(GO:0033631)
0.0	0.1	GO:0042487	regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.0	0.1	GO:0040016	embryonic cleavage(GO:0040016)
0.0	0.0	GO:0002043	blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.0	0.0	GO:0019240	citrulline biosynthetic process(GO:0019240)
0.0	0.1	GO:0070327	thyroid hormone transport(GO:0070327)
0.0	0.1	GO:0032988	ribonucleoprotein complex disassembly(GO:0032988)
0.0	0.0	GO:0006290	pyrimidine dimer repair(GO:0006290)
0.0	0.1	GO:0010507	negative regulation of autophagy(GO:0010507)
0.0	0.0	GO:2000193	positive regulation of fatty acid transport(GO:2000193)
0.0	0.1	GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.0	0.1	GO:0001757	somite specification(GO:0001757)
0.0	0.1	GO:0050922	negative regulation of chemotaxis(GO:0050922)
0.0	0.2	GO:0071456	cellular response to decreased oxygen levels(GO:0036294) cellular response to oxygen levels(GO:0071453) cellular response to hypoxia(GO:0071456)
0.0	0.1	GO:0006167	AMP biosynthetic process(GO:0006167)
0.0	0.1	GO:0006154	adenosine catabolic process(GO:0006154)
0.0	0.1	GO:0032455	nerve growth factor processing(GO:0032455)
0.0	0.0	GO:0002085	inhibition of neuroepithelial cell differentiation(GO:0002085)
0.0	0.1	GO:0055057	neuronal stem cell division(GO:0036445) neuroblast division(GO:0055057)
0.0	0.1	GO:0006654	phosphatidic acid biosynthetic process(GO:0006654)
0.0	0.1	GO:0051005	negative regulation of lipoprotein lipase activity(GO:0051005)
0.0	0.0	GO:0032849	positive regulation of cellular pH reduction(GO:0032849)
0.0	0.1	GO:0071421	manganese ion transmembrane transport(GO:0071421)
0.0	0.4	GO:0006084	acetyl-CoA metabolic process(GO:0006084)
0.0	0.1	GO:0032691	negative regulation of interleukin-1 beta production(GO:0032691)
0.0	0.2	GO:0046321	positive regulation of fatty acid oxidation(GO:0046321)
0.0	0.1	GO:0006106	fumarate metabolic process(GO:0006106)
0.0	0.3	GO:0035329	hippo signaling(GO:0035329)
0.0	0.1	GO:0042271	susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.0	0.1	GO:0015840	urea transport(GO:0015840)
0.0	0.3	GO:0042491	auditory receptor cell differentiation(GO:0042491)
0.0	0.1	GO:0035234	ectopic germ cell programmed cell death(GO:0035234)
0.0	0.0	GO:0051386	regulation of neurotrophin TRK receptor signaling pathway(GO:0051386)
0.0	0.2	GO:0021884	forebrain neuron development(GO:0021884)
0.0	0.1	GO:0017121	phospholipid scrambling(GO:0017121)
0.0	0.1	GO:0006556	S-adenosylmethionine biosynthetic process(GO:0006556)
0.0	0.1	GO:0043276	anoikis(GO:0043276)
0.0	0.1	GO:0006975	DNA damage induced protein phosphorylation(GO:0006975)
0.0	0.0	GO:0010664	striated muscle cell apoptotic process(GO:0010658) cardiac muscle cell apoptotic process(GO:0010659) regulation of striated muscle cell apoptotic process(GO:0010662) negative regulation of striated muscle cell apoptotic process(GO:0010664) regulation of cardiac muscle cell apoptotic process(GO:0010665) negative regulation of cardiac muscle cell apoptotic process(GO:0010667)
0.0	0.0	GO:0090273	regulation of somatostatin secretion(GO:0090273)
0.0	0.0	GO:0007549	dosage compensation(GO:0007549)
0.0	0.1	GO:0008295	spermidine biosynthetic process(GO:0008295)
0.0	0.3	GO:0006400	tRNA modification(GO:0006400)
0.0	0.3	GO:0042744	hydrogen peroxide catabolic process(GO:0042744)
0.0	0.1	GO:0032516	positive regulation of phosphoprotein phosphatase activity(GO:0032516)
0.0	0.0	GO:0072216	positive regulation of metanephros development(GO:0072216)
0.0	0.0	GO:0072047	proximal/distal pattern formation involved in nephron development(GO:0072047) specification of nephron tubule identity(GO:0072081)
0.0	0.1	GO:0006552	leucine catabolic process(GO:0006552)
0.0	0.0	GO:0001661	conditioned taste aversion(GO:0001661)
0.0	0.1	GO:0070508	sterol import(GO:0035376) cholesterol import(GO:0070508)
0.0	0.0	GO:0006551	leucine metabolic process(GO:0006551)
0.0	0.0	GO:0030538	embryonic genitalia morphogenesis(GO:0030538)
0.0	0.1	GO:0016265	obsolete death(GO:0016265)
0.0	0.1	GO:0034085	establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
0.0	0.1	GO:0006667	sphinganine metabolic process(GO:0006667)
0.0	0.1	GO:0050847	progesterone receptor signaling pathway(GO:0050847)
0.0	0.1	GO:0051532	NFAT protein import into nucleus(GO:0051531) regulation of NFAT protein import into nucleus(GO:0051532)
0.0	0.0	GO:0090267	positive regulation of spindle checkpoint(GO:0090232) regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267) positive regulation of cell cycle checkpoint(GO:1901978) regulation of mitotic spindle checkpoint(GO:1903504)
0.0	0.1	GO:0045429	positive regulation of nitric oxide biosynthetic process(GO:0045429) positive regulation of reactive oxygen species biosynthetic process(GO:1903428) positive regulation of nitric oxide metabolic process(GO:1904407)
0.0	0.0	GO:0001821	histamine secretion(GO:0001821)
0.0	0.0	GO:0055064	cellular chloride ion homeostasis(GO:0030644) chloride ion homeostasis(GO:0055064)
0.0	0.1	GO:0015889	cobalamin transport(GO:0015889)
0.0	0.1	GO:0070373	negative regulation of ERK1 and ERK2 cascade(GO:0070373)
0.0	0.0	GO:0060014	granulosa cell differentiation(GO:0060014)
0.0	0.1	GO:0010225	response to UV-C(GO:0010225)
0.0	0.0	GO:0060068	vagina development(GO:0060068)
0.0	0.1	GO:0042832	defense response to protozoan(GO:0042832)
0.0	0.1	GO:0014821	phasic smooth muscle contraction(GO:0014821)
0.0	0.0	GO:0051182	coenzyme transport(GO:0051182)
0.0	0.0	GO:0044803	multi-organism membrane organization(GO:0044803)
0.0	0.2	GO:0007274	neuromuscular synaptic transmission(GO:0007274)
0.0	0.0	GO:0045721	negative regulation of gluconeogenesis(GO:0045721)
0.0	0.0	GO:0007621	negative regulation of female receptivity(GO:0007621)
0.0	0.0	GO:0051459	corticotropin secretion(GO:0051458) regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461)
0.0	0.0	GO:0046952	ketone body catabolic process(GO:0046952)
0.0	0.1	GO:0019695	choline metabolic process(GO:0019695)
0.0	0.0	GO:0045085	negative regulation of interleukin-2 biosynthetic process(GO:0045085)
0.0	0.0	GO:0001562	response to protozoan(GO:0001562)
0.0	0.1	GO:0001542	ovulation from ovarian follicle(GO:0001542)
0.0	0.0	GO:0042268	regulation of cytolysis(GO:0042268)
0.0	0.1	GO:0043277	apoptotic cell clearance(GO:0043277)
0.0	0.1	GO:0022027	interkinetic nuclear migration(GO:0022027)
0.0	0.0	GO:0045162	clustering of voltage-gated sodium channels(GO:0045162)
0.0	0.0	GO:0051140	regulation of NK T cell proliferation(GO:0051140) positive regulation of NK T cell proliferation(GO:0051142)
0.0	0.1	GO:0016266	O-glycan processing(GO:0016266)
0.0	0.0	GO:0071636	positive regulation of transforming growth factor beta production(GO:0071636)
0.0	0.0	GO:0010989	negative regulation of low-density lipoprotein particle clearance(GO:0010989) low-density lipoprotein particle receptor catabolic process(GO:0032802)
0.0	0.1	GO:0045792	negative regulation of cell size(GO:0045792)
0.0	0.2	GO:0050873	brown fat cell differentiation(GO:0050873)
0.0	0.1	GO:0030321	transepithelial chloride transport(GO:0030321)
0.0	0.3	GO:0030433	ER-associated ubiquitin-dependent protein catabolic process(GO:0030433) ERAD pathway(GO:0036503)
0.0	0.1	GO:0070296	sarcoplasmic reticulum calcium ion transport(GO:0070296)
0.0	0.0	GO:0035461	vitamin transmembrane transport(GO:0035461)
0.0	0.1	GO:0032331	negative regulation of chondrocyte differentiation(GO:0032331)
0.0	0.0	GO:0010159	specification of organ position(GO:0010159)
0.0	0.0	GO:0060061	Spemann organizer formation(GO:0060061)
0.0	0.1	GO:0050872	white fat cell differentiation(GO:0050872)
0.0	0.0	GO:0006828	manganese ion transport(GO:0006828)
0.0	0.0	GO:0090162	establishment of epithelial cell polarity(GO:0090162)
0.0	0.1	GO:0007263	nitric oxide mediated signal transduction(GO:0007263)
0.0	0.0	GO:0072148	epithelial cell fate commitment(GO:0072148)
0.0	0.0	GO:0019987	obsolete negative regulation of anti-apoptosis(GO:0019987)
0.0	0.2	GO:0048286	lung alveolus development(GO:0048286)
0.0	0.1	GO:0046487	glyoxylate metabolic process(GO:0046487)
0.0	0.1	GO:0033008	positive regulation of mast cell activation involved in immune response(GO:0033008) positive regulation of leukocyte degranulation(GO:0043302) positive regulation of mast cell degranulation(GO:0043306)
0.0	0.0	GO:0015732	prostaglandin transport(GO:0015732)
0.0	0.1	GO:0051322	anaphase(GO:0051322)
0.0	0.3	GO:0009072	aromatic amino acid family metabolic process(GO:0009072)
0.0	0.2	GO:0007250	activation of NF-kappaB-inducing kinase activity(GO:0007250) NIK/NF-kappaB signaling(GO:0038061) regulation of NIK/NF-kappaB signaling(GO:1901222) positive regulation of NIK/NF-kappaB signaling(GO:1901224)
0.0	0.0	GO:0051409	response to nitrosative stress(GO:0051409)
0.0	0.1	GO:0050916	sensory perception of sweet taste(GO:0050916)
0.0	0.1	GO:0009649	entrainment of circadian clock(GO:0009649)
0.0	0.0	GO:0007262	STAT protein import into nucleus(GO:0007262)
0.0	0.0	GO:0072070	loop of Henle development(GO:0072070)
0.0	0.1	GO:1904357	negative regulation of telomere maintenance via telomere lengthening(GO:1904357)
0.0	0.1	GO:0008634	obsolete negative regulation of survival gene product expression(GO:0008634)
0.0	0.1	GO:0021952	central nervous system projection neuron axonogenesis(GO:0021952)
0.0	0.1	GO:0014912	negative regulation of smooth muscle cell migration(GO:0014912)
0.0	0.1	GO:0061462	protein targeting to lysosome(GO:0006622) protein targeting to vacuole(GO:0006623) protein localization to lysosome(GO:0061462) protein localization to vacuole(GO:0072665) establishment of protein localization to vacuole(GO:0072666)
0.0	0.1	GO:0003310	pancreatic A cell differentiation(GO:0003310)
0.0	0.0	GO:0042762	regulation of sulfur metabolic process(GO:0042762)
0.0	0.1	GO:0032926	negative regulation of activin receptor signaling pathway(GO:0032926)
0.0	0.1	GO:1904031	positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737) positive regulation of cyclin-dependent protein kinase activity(GO:1904031)
0.0	0.1	GO:0006776	vitamin A metabolic process(GO:0006776)
0.0	0.1	GO:0006564	L-serine biosynthetic process(GO:0006564)
0.0	0.0	GO:0010872	regulation of cholesterol esterification(GO:0010872)
0.0	0.1	GO:0051290	protein heterotetramerization(GO:0051290)
0.0	0.1	GO:0001660	fever generation(GO:0001660)
0.0	0.0	GO:0001778	plasma membrane repair(GO:0001778)
0.0	0.0	GO:0032344	regulation of ketone biosynthetic process(GO:0010566) regulation of aldosterone metabolic process(GO:0032344) regulation of aldosterone biosynthetic process(GO:0032347)
0.0	0.0	GO:0046501	protoporphyrinogen IX metabolic process(GO:0046501)
0.0	0.0	GO:0060119	inner ear receptor cell development(GO:0060119) inner ear receptor stereocilium organization(GO:0060122)
0.0	0.0	GO:0015853	adenine transport(GO:0015853)
0.0	0.0	GO:1904729	regulation of intestinal cholesterol absorption(GO:0030300) regulation of intestinal absorption(GO:1904478) regulation of intestinal lipid absorption(GO:1904729)
0.0	0.0	GO:0034421	post-translational protein acetylation(GO:0034421)
0.0	0.0	GO:0006434	seryl-tRNA aminoacylation(GO:0006434)
0.0	0.0	GO:0021819	layer formation in cerebral cortex(GO:0021819)
0.0	0.0	GO:0009296	obsolete flagellum assembly(GO:0009296)
0.0	0.2	GO:0008333	endosome to lysosome transport(GO:0008333)
0.0	0.0	GO:0008049	male courtship behavior(GO:0008049)
0.0	0.0	GO:0045048	protein insertion into ER membrane(GO:0045048) tail-anchored membrane protein insertion into ER membrane(GO:0071816)
0.0	0.1	GO:0015939	pantothenate metabolic process(GO:0015939)
0.0	0.0	GO:0032288	myelin assembly(GO:0032288)
0.0	0.0	GO:0003171	atrioventricular valve development(GO:0003171) atrioventricular valve morphogenesis(GO:0003181)
0.0	0.0	GO:0051124	synaptic growth at neuromuscular junction(GO:0051124)
0.0	0.0	GO:0031558	obsolete induction of apoptosis in response to chemical stimulus(GO:0031558)
0.0	0.1	GO:0045116	protein neddylation(GO:0045116)
0.0	0.0	GO:0042996	regulation of Golgi to plasma membrane protein transport(GO:0042996)
0.0	0.0	GO:0060536	trachea cartilage morphogenesis(GO:0060535) cartilage morphogenesis(GO:0060536)
0.0	0.1	GO:0035058	nonmotile primary cilium assembly(GO:0035058)
0.0	0.0	GO:0006122	mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.0	0.1	GO:0016584	nucleosome positioning(GO:0016584)
0.0	0.0	GO:0060236	regulation of mitotic spindle organization(GO:0060236)
0.0	0.1	GO:0002089	lens morphogenesis in camera-type eye(GO:0002089)
0.0	0.1	GO:0046500	S-adenosylmethionine metabolic process(GO:0046500)
0.0	0.1	GO:0009396	folic acid-containing compound biosynthetic process(GO:0009396)
0.0	0.0	GO:0008054	negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation(GO:0008054)
0.0	0.0	GO:0061154	endothelial tube morphogenesis(GO:0061154)
0.0	0.1	GO:0006020	inositol metabolic process(GO:0006020)
0.0	0.0	GO:0071354	cellular response to interleukin-6(GO:0071354)
0.0	0.0	GO:0032020	ISG15-protein conjugation(GO:0032020)
0.0	0.0	GO:0043954	cell junction maintenance(GO:0034331) cellular component maintenance(GO:0043954) cell-cell junction maintenance(GO:0045217)
0.0	0.2	GO:0006662	glycerol ether metabolic process(GO:0006662) ether metabolic process(GO:0018904)
0.0	0.0	GO:0010966	regulation of phosphate transport(GO:0010966)
0.0	0.0	GO:0060750	epithelial cell proliferation involved in mammary gland duct elongation(GO:0060750)
0.0	0.0	GO:2000051	planar cell polarity pathway involved in axis elongation(GO:0003402) regulation of planar cell polarity pathway involved in axis elongation(GO:2000040) negative regulation of planar cell polarity pathway involved in axis elongation(GO:2000041) negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.0	0.5	GO:0006446	regulation of translational initiation(GO:0006446)
0.0	0.0	GO:0015936	coenzyme A metabolic process(GO:0015936)
0.0	0.0	GO:0042640	anagen(GO:0042640)
0.0	0.1	GO:0003016	respiratory system process(GO:0003016)
0.0	0.0	GO:0044314	protein K27-linked ubiquitination(GO:0044314)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0005588	collagen type V trimer(GO:0005588)
0.1	0.2	GO:1903561	extracellular exosome(GO:0070062) extracellular vesicle(GO:1903561)
0.1	0.3	GO:0031265	CD95 death-inducing signaling complex(GO:0031265)
0.1	0.2	GO:0032449	CBM complex(GO:0032449)
0.1	0.2	GO:0000214	tRNA-intron endonuclease complex(GO:0000214)
0.1	0.2	GO:0043260	laminin-11 complex(GO:0043260)
0.1	0.2	GO:0005827	polar microtubule(GO:0005827)
0.0	0.2	GO:0035189	Rb-E2F complex(GO:0035189)
0.0	0.2	GO:0031211	palmitoyltransferase complex(GO:0002178) serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0	0.2	GO:0030061	mitochondrial crista(GO:0030061)
0.0	0.1	GO:0042405	nuclear inclusion body(GO:0042405)
0.0	0.1	GO:0005826	actomyosin contractile ring(GO:0005826)
0.0	0.1	GO:0031312	extrinsic component of organelle membrane(GO:0031312)
0.0	0.1	GO:0005915	zonula adherens(GO:0005915)
0.0	0.1	GO:0031045	dense core granule(GO:0031045)
0.0	0.1	GO:0016327	apicolateral plasma membrane(GO:0016327)
0.0	0.2	GO:0031095	platelet dense tubular network membrane(GO:0031095)
0.0	0.1	GO:0031465	Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.0	0.2	GO:0002102	podosome(GO:0002102)
0.0	0.1	GO:0071001	U4/U6 snRNP(GO:0071001)
0.0	0.4	GO:0005852	eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0	0.1	GO:0071664	catenin-TCF7L2 complex(GO:0071664)
0.0	0.1	GO:1990316	ATG1/ULK1 kinase complex(GO:1990316)
0.0	0.1	GO:0030688	preribosome, small subunit precursor(GO:0030688)
0.0	0.1	GO:0070695	FHF complex(GO:0070695)
0.0	0.1	GO:0000015	phosphopyruvate hydratase complex(GO:0000015)
0.0	0.2	GO:0030315	T-tubule(GO:0030315)
0.0	0.1	GO:0032059	bleb(GO:0032059)
0.0	0.1	GO:0031143	pseudopodium(GO:0031143)
0.0	0.1	GO:0030904	retromer complex(GO:0030904)
0.0	0.1	GO:0031232	extrinsic component of external side of plasma membrane(GO:0031232)
0.0	0.1	GO:0001740	Barr body(GO:0001740)
0.0	0.0	GO:0043240	Fanconi anaemia nuclear complex(GO:0043240)
0.0	0.2	GO:0043205	fibril(GO:0043205)
0.0	0.1	GO:0031233	intrinsic component of external side of plasma membrane(GO:0031233)
0.0	0.0	GO:0030056	hemidesmosome(GO:0030056)
0.0	0.1	GO:0098645	network-forming collagen trimer(GO:0098642) collagen network(GO:0098645)
0.0	0.1	GO:0005577	fibrinogen complex(GO:0005577)
0.0	0.1	GO:0030122	AP-2 adaptor complex(GO:0030122) clathrin coat of endocytic vesicle(GO:0030128)
0.0	0.4	GO:0043204	perikaryon(GO:0043204)
0.0	0.1	GO:0030877	beta-catenin destruction complex(GO:0030877)
0.0	0.1	GO:0048188	Set1C/COMPASS complex(GO:0048188)
0.0	0.1	GO:0005868	cytoplasmic dynein complex(GO:0005868)
0.0	0.1	GO:0008385	IkappaB kinase complex(GO:0008385)
0.0	0.0	GO:0070938	contractile ring(GO:0070938)
0.0	0.3	GO:0005844	polysome(GO:0005844)
0.0	0.2	GO:0016514	SWI/SNF complex(GO:0016514)
0.0	0.1	GO:0033179	proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.0	0.0	GO:0034673	inhibin-betaglycan-ActRII complex(GO:0034673)
0.0	0.1	GO:0016442	RISC complex(GO:0016442) RNAi effector complex(GO:0031332)
0.0	0.1	GO:0005593	FACIT collagen trimer(GO:0005593)
0.0	0.1	GO:0042555	MCM complex(GO:0042555)
0.0	0.1	GO:0031512	motile primary cilium(GO:0031512)
0.0	0.1	GO:0030127	COPII vesicle coat(GO:0030127)
0.0	0.0	GO:0070188	obsolete Stn1-Ten1 complex(GO:0070188)
0.0	0.0	GO:0071818	BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.0	0.5	GO:1903293	protein serine/threonine phosphatase complex(GO:0008287) phosphatase complex(GO:1903293)
0.0	0.0	GO:0005828	kinetochore microtubule(GO:0005828)
0.0	0.2	GO:0090545	NuRD complex(GO:0016581) CHD-type complex(GO:0090545) nuclear transcriptional repressor complex(GO:0090568)
0.0	0.2	GO:0000299	obsolete integral to membrane of membrane fraction(GO:0000299)
0.0	0.0	GO:0045277	mitochondrial respiratory chain complex IV(GO:0005751) respiratory chain complex IV(GO:0045277)
0.0	0.0	GO:0031838	haptoglobin-hemoglobin complex(GO:0031838)
0.0	0.1	GO:0005845	mRNA cap binding complex(GO:0005845) RNA cap binding complex(GO:0034518)
0.0	0.2	GO:0019005	SCF ubiquitin ligase complex(GO:0019005)
0.0	0.5	GO:0044853	caveola(GO:0005901) plasma membrane raft(GO:0044853)
0.0	0.0	GO:0033256	I-kappaB/NF-kappaB complex(GO:0033256)
0.0	0.1	GO:0000930	gamma-tubulin complex(GO:0000930)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.6	GO:0001601	peptide YY receptor activity(GO:0001601)
0.1	0.3	GO:0050253	retinyl-palmitate esterase activity(GO:0050253)
0.1	0.3	GO:0016174	NAD(P)H oxidase activity(GO:0016174)
0.1	0.3	GO:0030976	thiamine pyrophosphate binding(GO:0030976)
0.1	0.2	GO:0030881	beta-2-microglobulin binding(GO:0030881)
0.1	0.4	GO:0004630	phospholipase D activity(GO:0004630)
0.1	0.2	GO:0051371	muscle alpha-actinin binding(GO:0051371)
0.1	0.2	GO:0050542	icosanoid binding(GO:0050542) fatty acid derivative binding(GO:1901567)
0.1	0.2	GO:0004332	fructose-bisphosphate aldolase activity(GO:0004332)
0.1	0.2	GO:0004886	9-cis retinoic acid receptor activity(GO:0004886)
0.0	0.3	GO:0015220	choline transmembrane transporter activity(GO:0015220)
0.0	0.1	GO:0005152	interleukin-1 receptor antagonist activity(GO:0005152)
0.0	0.3	GO:0047372	acylglycerol lipase activity(GO:0047372)
0.0	0.2	GO:0004157	dihydropyrimidinase activity(GO:0004157)
0.0	0.2	GO:0004668	protein-arginine deiminase activity(GO:0004668)
0.0	0.1	GO:0070324	thyroid hormone binding(GO:0070324)
0.0	0.2	GO:0016933	extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.0	0.2	GO:0005010	insulin-like growth factor-activated receptor activity(GO:0005010)
0.0	0.1	GO:0016774	phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.0	0.2	GO:0004982	N-formyl peptide receptor activity(GO:0004982)
0.0	0.2	GO:0001595	angiotensin receptor activity(GO:0001595) angiotensin type II receptor activity(GO:0004945)
0.0	0.2	GO:0010314	phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0	0.2	GO:0004594	pantothenate kinase activity(GO:0004594)
0.0	0.2	GO:0048185	activin binding(GO:0048185)
0.0	0.1	GO:0016151	nickel cation binding(GO:0016151)
0.0	0.3	GO:0017166	vinculin binding(GO:0017166)
0.0	0.4	GO:0048407	platelet-derived growth factor binding(GO:0048407)
0.0	0.3	GO:0005112	Notch binding(GO:0005112)
0.0	0.1	GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0	0.3	GO:0042171	1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) lysophosphatidic acid acyltransferase activity(GO:0042171) lysophospholipid acyltransferase activity(GO:0071617)
0.0	0.1	GO:0030215	semaphorin receptor binding(GO:0030215)
0.0	0.1	GO:0015184	L-cystine transmembrane transporter activity(GO:0015184)
0.0	0.1	GO:0008109	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0	0.1	GO:0016728	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.0	0.1	GO:0001758	retinal dehydrogenase activity(GO:0001758)
0.0	0.1	GO:0003708	retinoic acid receptor activity(GO:0003708)
0.0	0.1	GO:0004768	stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215)
0.0	0.1	GO:0005534	galactose binding(GO:0005534)
0.0	0.1	GO:0030235	nitric-oxide synthase regulator activity(GO:0030235)
0.0	0.1	GO:0008321	Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0	0.2	GO:0004908	interleukin-1 receptor activity(GO:0004908)
0.0	0.1	GO:0030911	TPR domain binding(GO:0030911)
0.0	0.3	GO:0005123	death receptor binding(GO:0005123)
0.0	0.2	GO:0016165	linoleate 13S-lipoxygenase activity(GO:0016165)
0.0	0.1	GO:0005432	calcium:sodium antiporter activity(GO:0005432)
0.0	0.1	GO:0004566	beta-glucuronidase activity(GO:0004566)
0.0	0.1	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0	0.1	GO:0001515	opioid peptide activity(GO:0001515)
0.0	0.1	GO:0005384	manganese ion transmembrane transporter activity(GO:0005384)
0.0	0.0	GO:0070273	phosphatidylinositol-4-phosphate binding(GO:0070273)
0.0	0.1	GO:0004117	calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117)
0.0	0.1	GO:0004758	serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0	0.1	GO:0004992	platelet activating factor receptor activity(GO:0004992)
0.0	0.0	GO:0003829	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0003829)
0.0	0.1	GO:0050501	hyaluronan synthase activity(GO:0050501)
0.0	0.1	GO:0004720	protein-lysine 6-oxidase activity(GO:0004720)
0.0	0.1	GO:0008046	axon guidance receptor activity(GO:0008046)
0.0	0.0	GO:0050682	AF-2 domain binding(GO:0050682)
0.0	0.1	GO:0015204	urea transmembrane transporter activity(GO:0015204)
0.0	0.1	GO:0034186	apolipoprotein A-I binding(GO:0034186)
0.0	0.1	GO:0070052	collagen V binding(GO:0070052)
0.0	0.2	GO:0043208	glycosphingolipid binding(GO:0043208)
0.0	0.2	GO:0030544	Hsp70 protein binding(GO:0030544)
0.0	0.2	GO:0015321	sodium-dependent phosphate transmembrane transporter activity(GO:0015321)
0.0	0.1	GO:0004430	1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.0	0.0	GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717)
0.0	0.1	GO:0045236	CXCR chemokine receptor binding(GO:0045236)
0.0	0.0	GO:0000099	sulfur amino acid transmembrane transporter activity(GO:0000099)
0.0	0.1	GO:0030172	troponin C binding(GO:0030172)
0.0	0.2	GO:0008199	ferric iron binding(GO:0008199)
0.0	0.1	GO:0001609	G-protein coupled adenosine receptor activity(GO:0001609)
0.0	0.1	GO:0019855	calcium channel inhibitor activity(GO:0019855)
0.0	0.1	GO:0043008	ATP-dependent protein binding(GO:0043008)
0.0	0.1	GO:0031434	mitogen-activated protein kinase kinase binding(GO:0031434)
0.0	0.1	GO:0043184	vascular endothelial growth factor receptor 2 binding(GO:0043184)
0.0	0.1	GO:0070579	methylcytosine dioxygenase activity(GO:0070579)
0.0	0.1	GO:0016623	oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor(GO:0016623)
0.0	0.4	GO:0005024	transforming growth factor beta-activated receptor activity(GO:0005024)
0.0	0.1	GO:0009374	biotin binding(GO:0009374)
0.0	0.2	GO:0003810	protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0	0.1	GO:0045545	syndecan binding(GO:0045545)
0.0	0.1	GO:0030274	LIM domain binding(GO:0030274)
0.0	0.1	GO:0008184	glycogen phosphorylase activity(GO:0008184)
0.0	0.1	GO:0001849	complement component C1q binding(GO:0001849)
0.0	0.0	GO:0050431	transforming growth factor beta binding(GO:0050431)
0.0	0.2	GO:0050811	GABA receptor binding(GO:0050811)
0.0	0.0	GO:0008607	phosphorylase kinase regulator activity(GO:0008607)
0.0	0.1	GO:0047184	1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184)
0.0	0.3	GO:0005086	ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0	0.1	GO:0030297	transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.0	0.2	GO:0044548	S100 protein binding(GO:0044548)
0.0	0.2	GO:0070016	armadillo repeat domain binding(GO:0070016)
0.0	0.1	GO:0017169	CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.0	0.1	GO:0017128	phospholipid scramblase activity(GO:0017128)
0.0	0.1	GO:0034237	protein kinase A regulatory subunit binding(GO:0034237)
0.0	0.1	GO:0016286	small conductance calcium-activated potassium channel activity(GO:0016286)
0.0	0.1	GO:0017154	semaphorin receptor activity(GO:0017154)
0.0	0.1	GO:0016595	glutamate binding(GO:0016595)
0.0	0.2	GO:0004549	tRNA-specific ribonuclease activity(GO:0004549)
0.0	0.1	GO:0030492	hemoglobin binding(GO:0030492)
0.0	0.1	GO:0000987	RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.0	0.2	GO:0016500	protein-hormone receptor activity(GO:0016500)
0.0	0.1	GO:0008113	peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.0	0.2	GO:0004312	fatty acid synthase activity(GO:0004312)
0.0	0.1	GO:0005332	gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.0	0.1	GO:0019788	NEDD8 transferase activity(GO:0019788)
0.0	0.0	GO:0004645	phosphorylase activity(GO:0004645)
0.0	0.1	GO:0003846	2-acylglycerol O-acyltransferase activity(GO:0003846)
0.0	0.1	GO:0004028	3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.0	0.2	GO:0051010	microtubule plus-end binding(GO:0051010)
0.0	0.0	GO:0004477	methenyltetrahydrofolate cyclohydrolase activity(GO:0004477)
0.0	0.1	GO:0071553	uridine nucleotide receptor activity(GO:0015065) G-protein coupled pyrimidinergic nucleotide receptor activity(GO:0071553)
0.0	0.1	GO:0030506	ankyrin binding(GO:0030506)
0.0	0.1	GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0	0.0	GO:0019834	phospholipase A2 inhibitor activity(GO:0019834)
0.0	0.1	GO:0048406	nerve growth factor binding(GO:0048406)
0.0	0.1	GO:0015279	store-operated calcium channel activity(GO:0015279)
0.0	0.1	GO:0070411	I-SMAD binding(GO:0070411)
0.0	0.1	GO:0016018	cyclosporin A binding(GO:0016018)
0.0	0.0	GO:0005042	netrin receptor activity(GO:0005042)
0.0	0.0	GO:0002054	nucleobase binding(GO:0002054)
0.0	0.1	GO:0004849	uridine kinase activity(GO:0004849)
0.0	0.2	GO:0005355	glucose transmembrane transporter activity(GO:0005355)
0.0	0.1	GO:0016520	growth hormone-releasing hormone receptor activity(GO:0016520)
0.0	0.3	GO:0043022	ribosome binding(GO:0043022)
0.0	0.2	GO:0070717	poly-purine tract binding(GO:0070717)
0.0	0.1	GO:0034416	bisphosphoglycerate phosphatase activity(GO:0034416)
0.0	0.1	GO:0017089	glycolipid transporter activity(GO:0017089)
0.0	0.2	GO:0043176	amine binding(GO:0043176)
0.0	0.1	GO:0004634	phosphopyruvate hydratase activity(GO:0004634)
0.0	0.1	GO:0005000	vasopressin receptor activity(GO:0005000)
0.0	0.2	GO:0043498	obsolete cell surface binding(GO:0043498)
0.0	0.6	GO:0004722	protein serine/threonine phosphatase activity(GO:0004722)
0.0	0.3	GO:0016505	peptidase activator activity involved in apoptotic process(GO:0016505)
0.0	0.1	GO:0016901	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor(GO:0016901)
0.0	0.1	GO:0008641	small protein activating enzyme activity(GO:0008641)
0.0	0.0	GO:0015254	glycerol channel activity(GO:0015254)
0.0	0.0	GO:0004995	tachykinin receptor activity(GO:0004995)
0.0	0.6	GO:0008009	chemokine activity(GO:0008009)
0.0	0.0	GO:0097493	extracellular matrix constituent conferring elasticity(GO:0030023) structural molecule activity conferring elasticity(GO:0097493)
0.0	0.1	GO:0017080	sodium channel regulator activity(GO:0017080)
0.0	0.1	GO:0047617	acyl-CoA hydrolase activity(GO:0047617)
0.0	0.1	GO:0008273	calcium, potassium:sodium antiporter activity(GO:0008273)
0.0	0.1	GO:0003997	acyl-CoA oxidase activity(GO:0003997)
0.0	0.0	GO:0005172	vascular endothelial growth factor receptor binding(GO:0005172)
0.0	0.1	GO:0004439	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity(GO:0004439)
0.0	0.2	GO:0004198	calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0	0.1	GO:0070700	transmembrane receptor protein serine/threonine kinase binding(GO:0070696) BMP receptor binding(GO:0070700)
0.0	0.0	GO:0004104	cholinesterase activity(GO:0004104)
0.0	0.1	GO:0004427	inorganic diphosphatase activity(GO:0004427)
0.0	0.0	GO:0005294	neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.0	0.1	GO:0050998	nitric-oxide synthase binding(GO:0050998)
0.0	0.0	GO:0042285	UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285)
0.0	0.1	GO:0004859	phospholipase inhibitor activity(GO:0004859)
0.0	0.3	GO:0050840	extracellular matrix binding(GO:0050840)
0.0	0.0	GO:0004366	glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
0.0	0.1	GO:0070513	death domain binding(GO:0070513)
0.0	0.0	GO:0004828	serine-tRNA ligase activity(GO:0004828)
0.0	0.0	GO:0052659	inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658) inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity(GO:0052659)
0.0	0.0	GO:0004505	phenylalanine 4-monooxygenase activity(GO:0004505)
0.0	0.1	GO:0016813	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.0	0.1	GO:0008198	ferrous iron binding(GO:0008198)
0.0	0.0	GO:0003691	double-stranded telomeric DNA binding(GO:0003691)
0.0	0.0	GO:0004515	nicotinamide-nucleotide adenylyltransferase activity(GO:0000309) nicotinate-nucleotide adenylyltransferase activity(GO:0004515)
0.0	0.1	GO:0008172	S-methyltransferase activity(GO:0008172)
0.0	0.1	GO:0001530	lipopolysaccharide binding(GO:0001530)
0.0	0.0	GO:0002162	dystroglycan binding(GO:0002162)
0.0	0.1	GO:0019894	kinesin binding(GO:0019894)
0.0	0.1	GO:0004046	aminoacylase activity(GO:0004046)
0.0	0.1	GO:0016944	obsolete RNA polymerase II transcription elongation factor activity(GO:0016944)
0.0	0.1	GO:0008504	monoamine transmembrane transporter activity(GO:0008504)
0.0	0.0	GO:0070548	L-glutamine aminotransferase activity(GO:0070548)
0.0	0.0	GO:0004967	glucagon receptor activity(GO:0004967)
0.0	0.0	GO:0005078	MAP-kinase scaffold activity(GO:0005078)
0.0	0.1	GO:0030371	translation repressor activity(GO:0030371)
0.0	0.1	GO:0042301	phosphate ion binding(GO:0042301)
0.0	0.1	GO:0001077	transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0000982) transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0	0.1	GO:0000339	RNA cap binding(GO:0000339)
0.0	0.0	GO:0004111	creatine kinase activity(GO:0004111)
0.0	0.0	GO:0004060	arylamine N-acetyltransferase activity(GO:0004060)
0.0	0.0	GO:0019211	phosphatase activator activity(GO:0019211)
0.0	0.0	GO:0004706	JUN kinase kinase kinase activity(GO:0004706)
0.0	0.2	GO:0032947	protein complex scaffold(GO:0032947)
0.0	0.0	GO:0051400	BH domain binding(GO:0051400)
0.0	0.0	GO:0005094	Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0	0.0	GO:0045569	TRAIL binding(GO:0045569)
0.0	0.1	GO:0004128	cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.0	0.1	GO:0005154	epidermal growth factor receptor binding(GO:0005154)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.1	PID PDGFRA PATHWAY	PDGFR-alpha signaling pathway
0.2	PID NETRIN PATHWAY	Netrin-mediated signaling events
0.5	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
0.1	PID FAK PATHWAY	Signaling events mediated by focal adhesion kinase
0.5	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor
0.8	PID INTEGRIN3 PATHWAY	Beta3 integrin cell surface interactions
0.0	PID S1P S1P2 PATHWAY	S1P2 pathway
0.6	PID UPA UPAR PATHWAY	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.1	NABA BASEMENT MEMBRANES	Genes encoding structural components of basement membranes
0.6	PID SYNDECAN 1 PATHWAY	Syndecan-1-mediated signaling events
0.0	PID AMB2 NEUTROPHILS PATHWAY	amb2 Integrin signaling
0.5	ST GA13 PATHWAY	G alpha 13 Pathway
0.1	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
0.4	PID LIS1 PATHWAY	Lissencephaly gene (LIS1) in neuronal migration and development
0.2	PID SYNDECAN 2 PATHWAY	Syndecan-2-mediated signaling events
0.3	ST MYOCYTE AD PATHWAY	Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.2	SA G1 AND S PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.0	PID LYMPH ANGIOGENESIS PATHWAY	VEGFR3 signaling in lymphatic endothelium
0.1	PID GMCSF PATHWAY	GMCSF-mediated signaling events
0.1	PID VEGFR1 2 PATHWAY	Signaling events mediated by VEGFR1 and VEGFR2
0.1	PID LPA4 PATHWAY	LPA4-mediated signaling events
0.0	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.3	PID MAPK TRK PATHWAY	Trk receptor signaling mediated by the MAPK pathway
0.2	SA B CELL RECEPTOR COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.1	PID PI3K PLC TRK PATHWAY	Trk receptor signaling mediated by PI3K and PLC-gamma

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.2	REACTOME IL 3 5 AND GM CSF SIGNALING	Genes involved in Interleukin-3, 5 and GM-CSF signaling
0.5	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.0	REACTOME POST NMDA RECEPTOR ACTIVATION EVENTS	Genes involved in Post NMDA receptor activation events
0.4	REACTOME TRYPTOPHAN CATABOLISM	Genes involved in Tryptophan catabolism
0.4	REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10	Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
0.0	REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE	Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.4	REACTOME METABOLISM OF PORPHYRINS	Genes involved in Metabolism of porphyrins
0.3	REACTOME VITAMIN B5 PANTOTHENATE METABOLISM	Genes involved in Vitamin B5 (pantothenate) metabolism
0.3	REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1	Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.1	REACTOME REGULATION OF KIT SIGNALING	Genes involved in Regulation of KIT signaling
0.3	REACTOME THE NLRP3 INFLAMMASOME	Genes involved in The NLRP3 inflammasome
0.2	REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS	Genes involved in Elevation of cytosolic Ca2+ levels
0.3	REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS	Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0	REACTOME REGULATION OF APOPTOSIS	Genes involved in Regulation of Apoptosis
0.6	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.2	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.0	REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM	Genes involved in Cytokine Signaling in Immune system
0.2	REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK	Genes involved in Regulation of Rheb GTPase activity by AMPK
0.5	REACTOME AMINE COMPOUND SLC TRANSPORTERS	Genes involved in Amine compound SLC transporters
0.1	REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES	Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.2	REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES	Genes involved in Recruitment of NuMA to mitotic centrosomes
0.3	REACTOME HDL MEDIATED LIPID TRANSPORT	Genes involved in HDL-mediated lipid transport
0.2	REACTOME UNWINDING OF DNA	Genes involved in Unwinding of DNA
0.2	REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.3	REACTOME SYNTHESIS OF PA	Genes involved in Synthesis of PA
0.1	REACTOME NOTCH HLH TRANSCRIPTION PATHWAY	Genes involved in Notch-HLH transcription pathway
0.1	REACTOME PLATELET CALCIUM HOMEOSTASIS	Genes involved in Platelet calcium homeostasis
0.2	REACTOME OTHER SEMAPHORIN INTERACTIONS	Genes involved in Other semaphorin interactions
0.0	REACTOME SHC1 EVENTS IN EGFR SIGNALING	Genes involved in SHC1 events in EGFR signaling
0.1	REACTOME ERKS ARE INACTIVATED	Genes involved in ERKs are inactivated
0.2	REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING	Genes involved in Downregulation of TGF-beta receptor signaling
0.5	REACTOME TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3 SMAD4 HETEROTRIMER	Genes involved in Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
0.0	REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS	Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0	REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND	Genes involved in Removal of the Flap Intermediate from the C-strand
0.2	REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE	Genes involved in Synthesis of PIPs at the Golgi membrane
0.7	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.8	REACTOME RNA POL I PROMOTER OPENING	Genes involved in RNA Polymerase I Promoter Opening
0.2	REACTOME SHC1 EVENTS IN ERBB4 SIGNALING	Genes involved in SHC1 events in ERBB4 signaling
0.3	REACTOME ACYL CHAIN REMODELLING OF PC	Genes involved in Acyl chain remodelling of PC
0.1	REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1	Genes involved in IKK complex recruitment mediated by RIP1
0.1	REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS	Genes involved in Apoptotic cleavage of cell adhesion proteins
0.1	REACTOME TIE2 SIGNALING	Genes involved in Tie2 Signaling
0.1	REACTOME PRE NOTCH PROCESSING IN GOLGI	Genes involved in Pre-NOTCH Processing in Golgi
0.1	REACTOME DAG AND IP3 SIGNALING	Genes involved in DAG and IP3 signaling
0.1	REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS	Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.1	REACTOME NEPHRIN INTERACTIONS	Genes involved in Nephrin interactions
0.6	REACTOME GLUCOSE METABOLISM	Genes involved in Glucose metabolism
0.1	REACTOME COMMON PATHWAY	Genes involved in Common Pathway
0.0	REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.1	REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.8	REACTOME L1CAM INTERACTIONS	Genes involved in L1CAM interactions
0.1	REACTOME HS GAG DEGRADATION	Genes involved in HS-GAG degradation
0.2	REACTOME CHOLESTEROL BIOSYNTHESIS	Genes involved in Cholesterol biosynthesis
0.3	REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS	Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.2	REACTOME FATTY ACYL COA BIOSYNTHESIS	Genes involved in Fatty Acyl-CoA Biosynthesis

Results for MLX_USF2_USF1_PAX2

Z-value: 1.54

Motif logo

Transcription factors associated with MLX_USF2_USF1_PAX2

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Activity of the MLX_USF2_USF1_PAX2 motif across conditions

Conditions sorted by the z-value of the MLX_USF2_USF1_PAX2 motif activity

Top target CREs of the motif:

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of MLX_USF2_USF1_PAX2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: