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ENCODE: H3K4me1 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for MSX1

Z-value: 1.28

Motif logo

Transcription factors associated with MSX1

Gene Symbol	Gene ID	Gene Info
MSX1 Ensembl NCBI GeneCards UniProt	ENSG00000163132.6	MSX1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
MSX1	chr4_4862740_4862954	1454	0.530254	-0.81	7.9e-03	Click!
MSX1	chr4_4860648_4860832	653	0.801189	-0.80	8.9e-03	Click!
MSX1	chr4_4857303_4857507	3988	0.321058	-0.75	1.9e-02	Click!
MSX1	chr4_4793701_4793852	67617	0.125212	0.72	2.7e-02	Click!
MSX1	chr4_4862254_4862686	1077	0.636089	-0.60	8.5e-02	Click!

Activity of the MSX1 motif across conditions

Conditions sorted by the z-value of the MSX1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr10_93221945_93222246	0.65	HECTD2	HECT domain containing E3 ubiquitin protein ligase 2	198	0.97
chr7_116416400_116416551	0.60	MET	met proto-oncogene	754	0.71
chr1_206593311_206593758	0.59	SRGAP2	SLIT-ROBO Rho GTPase activating protein 2	13798	0.17
chr14_69015594_69016105	0.55	CTD-2325P2.4		79313	0.1
chr9_4137653_4137928	0.48	GLIS3	GLIS family zinc finger 3	7403	0.28
chr8_41906632_41907752	0.47	KAT6A	K(lysine) acetyltransferase 6A	2313	0.3
chr18_12598337_12598791	0.45	SPIRE1	spire-type actin nucleation factor 1	54520	0.09
chr17_46080195_46080690	0.45	RP11-6N17.10		6880	0.1
chr3_152787726_152787975	0.44	RP11-529G21.2		91714	0.08
chr5_9622384_9622535	0.43	TAS2R1	taste receptor, type 2, member 1	8004	0.22
chr14_35629047_35629198	0.43	KIAA0391	KIAA0391	37157	0.15
chr14_72179521_72179805	0.43	SIPA1L1	signal-induced proliferation-associated 1 like 1	94190	0.09
chr11_9927954_9928253	0.42	ENSG00000252568	.	62680	0.11
chr13_77518573_77518724	0.41	IRG1	immunoresponsive 1 homolog (mouse)	3984	0.24
chr4_78502666_78502963	0.41	CXCL13	chemokine (C-X-C motif) ligand 13	69907	0.13
chr10_75987768_75988344	0.40	ADK	adenosine kinase	51535	0.15
chr13_31440489_31440640	0.40	MEDAG	mesenteric estrogen-dependent adipogenesis	39764	0.16
chr15_101143578_101144308	0.40	ASB7	ankyrin repeat and SOCS box containing 7	1129	0.36
chr6_2103859_2104525	0.39	GMDS	GDP-mannose 4,6-dehydratase	72033	0.13
chr3_111820782_111820933	0.39	ENSG00000207940	.	10791	0.15
chr7_101457741_101458764	0.39	CUX1	cut-like homeobox 1	707	0.73
chr7_46949633_46949784	0.38	AC011294.3	Uncharacterized protein	212988	0.03
chr16_18980279_18980782	0.38	TMC7	transmembrane channel-like 7	14726	0.14
chr5_110849348_110849548	0.38	STARD4	StAR-related lipid transfer (START) domain containing 4	1160	0.42
chr14_42683704_42683855	0.38	ENSG00000222084	.	86175	0.1
chr4_146467395_146467619	0.38	SMAD1-AS1	SMAD1 antisense RNA 1	29237	0.17
chr5_66356025_66356176	0.38	MAST4	microtubule associated serine/threonine kinase family member 4	55617	0.15
chr4_170582263_170582414	0.37	CLCN3	chloride channel, voltage-sensitive 3	1125	0.6
chr22_26717807_26718076	0.37	SEZ6L	seizure related 6 homolog (mouse)-like	25740	0.18
chr2_227312371_227312522	0.37	ENSG00000263363	.	211063	0.02
chr13_103360569_103360720	0.37	ENSG00000238869	.	13508	0.13
chr3_188251532_188251683	0.37	LPP-AS1	LPP antisense RNA 1	34847	0.2
chr7_116347170_116347321	0.37	MET	met proto-oncogene	8106	0.26
chr12_109195761_109195912	0.37	ENSG00000264043	.	23789	0.13
chr5_34052813_34052964	0.37	C1QTNF3	C1q and tumor necrosis factor related protein 3	8951	0.23
chr17_60897719_60897987	0.37	MARCH10	membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase	12148	0.25
chr7_42030328_42030605	0.36	GLI3	GLI family zinc finger 3	236854	0.02
chr19_13147341_13147492	0.36	NFIX	nuclear factor I/X (CCAAT-binding transcription factor)	11605	0.1
chr12_91290582_91290865	0.36	CCER1	coiled-coil glutamate-rich protein 1	58230	0.15
chr1_234754493_234754778	0.35	IRF2BP2	interferon regulatory factor 2 binding protein 2	9364	0.19
chr2_47006358_47006650	0.35	LINC01118	long intergenic non-protein coding RNA 1118	37318	0.13
chr20_44409069_44409220	0.35	ENSG00000221046	.	1807	0.19
chr17_32580574_32580862	0.34	CCL2	chemokine (C-C motif) ligand 2	1586	0.24
chr15_78594610_78594888	0.34	WDR61	WD repeat domain 61	2613	0.18
chr6_139729934_139730085	0.34	CITED2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	34252	0.22
chr9_111235960_111236111	0.34	ENSG00000222512	.	114826	0.07
chr4_157860965_157861230	0.34	PDGFC	platelet derived growth factor C	30958	0.19
chr10_60420713_60420913	0.34	BICC1	bicaudal C homolog 1 (Drosophila)	132482	0.05
chr1_224076219_224076370	0.34	TP53BP2	tumor protein p53 binding protein, 2	42620	0.17
chr4_139232146_139232297	0.34	SLC7A11	solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11	68718	0.14
chr5_53683581_53683732	0.33	HSPB3	heat shock 27kDa protein 3	67789	0.12
chr3_114959246_114959397	0.33	ZBTB20	zinc finger and BTB domain containing 20	93203	0.1
chr3_12550506_12550657	0.33	ENSG00000200114	.	2131	0.22
chr10_95202028_95202179	0.33	MYOF	myoferlin	39848	0.15
chr9_111207476_111207627	0.33	ENSG00000222512	.	86342	0.11
chr1_113088087_113088238	0.33	RP4-671G15.2		27099	0.14
chr6_37850154_37850385	0.33	ENSG00000200597	.	33080	0.16
chr1_224820105_224820256	0.33	CNIH3	cornichon family AMPA receptor auxiliary protein 3	16185	0.19
chr22_28144785_28145032	0.32	RP11-375H17.1		32440	0.2
chr1_8106369_8106520	0.32	ERRFI1	ERBB receptor feedback inhibitor 1	20076	0.2
chr7_102477303_102477454	0.32	ENSG00000252643	.	2326	0.29
chr2_150601107_150601258	0.32	ENSG00000207270	.	133894	0.05
chr6_72113075_72113298	0.32	ENSG00000207827	.	138	0.97
chr3_8979557_8979708	0.32	ENSG00000199815	.	6453	0.22
chr10_63734512_63734894	0.32	ENSG00000221272	.	47926	0.17
chr21_30331573_30331724	0.32	LTN1	listerin E3 ubiquitin protein ligase 1	33558	0.14
chr2_224950724_224950875	0.32	SERPINE2	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2	46763	0.17
chr2_38918276_38918577	0.32	GALM	galactose mutarotase (aldose 1-epimerase)	9989	0.17
chr11_130451238_130451517	0.32	C11orf44	chromosome 11 open reading frame 44	91474	0.09
chr7_80512457_80512608	0.32	SEMA3C	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C	35967	0.24
chr16_54960016_54960167	0.32	IRX5	iroquois homeobox 5	4683	0.36
chr11_46071541_46071813	0.31	PHF21A	PHD finger protein 21A	42079	0.15
chrX_24166137_24167088	0.31	ZFX	zinc finger protein, X-linked	1134	0.35
chr3_81474618_81474769	0.31	ENSG00000222389	.	83934	0.11
chr11_102321739_102322277	0.31	TMEM123	transmembrane protein 123	46	0.96
chr3_16024682_16024833	0.31	ENSG00000207815	.	109479	0.06
chr7_151190654_151190805	0.31	RHEB	Ras homolog enriched in brain	24426	0.13
chr20_36815816_36815967	0.31	TGM2	transglutaminase 2	20911	0.17
chr5_72713863_72714014	0.31	FOXD1	forkhead box D1	30414	0.18
chr2_225543203_225543354	0.31	CUL3	cullin 3	93168	0.09
chr12_45627192_45627343	0.31	ANO6	anoctamin 6	17364	0.28
chr15_90950843_90951750	0.31	RP11-154B12.3		10183	0.16
chr5_73497876_73498136	0.31	ENSG00000222551	.	69584	0.13
chr2_242318504_242318655	0.31	FARP2	FERM, RhoGEF and pleckstrin domain protein 2	6315	0.17
chr10_65024052_65024675	0.31	JMJD1C	jumonji domain containing 1C	4463	0.31
chr11_121532407_121532558	0.30	SORL1	sortilin-related receptor, L(DLR class) A repeats containing	71354	0.13
chr1_172290576_172290727	0.30	ENSG00000252354	.	26632	0.17
chr9_14281034_14281328	0.30	NFIB	nuclear factor I/B	26831	0.22
chr6_52289660_52289856	0.30	EFHC1	EF-hand domain (C-terminal) containing 1	1288	0.54
chr9_81321983_81322311	0.30	PSAT1	phosphoserine aminotransferase 1	410088	0.01
chr10_50760988_50761139	0.30	ERCC6	excision repair cross-complementing rodent repair deficiency, complementation group 6	13479	0.15
chr13_47207440_47207736	0.30	LRCH1	leucine-rich repeats and calponin homology (CH) domain containing 1	46383	0.18
chrX_45570754_45570905	0.30	ENSG00000207870	.	34865	0.19
chr13_45294845_45294996	0.30	ENSG00000238932	.	92111	0.09
chr10_117532445_117532596	0.30	ATRNL1	attractin-like 1	471037	0.01
chr12_89339824_89340184	0.30	ENSG00000238302	.	336058	0.01
chr4_152277546_152277697	0.30	FAM160A1	family with sequence similarity 160, member A1	52777	0.13
chr2_65581901_65582416	0.30	SPRED2	sprouty-related, EVH1 domain containing 2	10238	0.23
chr9_137251018_137251277	0.30	ENSG00000263897	.	20110	0.22
chr4_174132836_174132987	0.30	RP11-10K16.1		42108	0.13
chr11_96059054_96059205	0.30	ENSG00000266192	.	15473	0.19
chr5_153826475_153827364	0.30	SAP30L	SAP30-like	814	0.51
chr3_97636799_97636950	0.30	CRYBG3	beta-gamma crystallin domain containing 3	6182	0.25
chr12_58923583_58923734	0.30	RP11-362K2.2	Protein LOC100506869	14249	0.3
chr4_184558434_184558585	0.30	ENSG00000252157	.	16320	0.14
chr17_39222775_39222926	0.30	KRTAP2-4	keratin associated protein 2-4	719	0.36
chr17_53804938_53805089	0.30	TMEM100	transmembrane protein 100	4469	0.29
chr13_107156553_107156704	0.30	EFNB2	ephrin-B2	30834	0.23
chr2_43941438_43941589	0.30	ENSG00000252490	.	57976	0.11
chr14_100376837_100376988	0.30	EML1	echinoderm microtubule associated protein like 1	12342	0.2
chr7_80350905_80351077	0.30	CD36	CD36 molecule (thrombospondin receptor)	48299	0.19
chr8_42409885_42410036	0.29	SMIM19	small integral membrane protein 19	8389	0.18
chr4_14728667_14728818	0.29	ENSG00000202449	.	36408	0.24
chr7_29662924_29663075	0.29	DPY19L2P3	DPY19L2 pseudogene 3	26844	0.17
chr6_121988152_121988303	0.29	ENSG00000222659	.	86560	0.1
chr9_74299304_74300206	0.29	TMEM2	transmembrane protein 2	20093	0.28
chr16_24742094_24743166	0.29	TNRC6A	trinucleotide repeat containing 6A	1596	0.5
chr2_68420623_68420967	0.29	RP11-474G23.2		13830	0.14
chr4_148693217_148693552	0.29	ENSG00000264274	.	10362	0.18
chr5_136117041_136117192	0.29	ENSG00000222285	.	187879	0.03
chr12_64565372_64565523	0.29	RP11-196H14.3		23810	0.14
chr11_13310143_13310461	0.29	ARNTL	aryl hydrocarbon receptor nuclear translocator-like	10870	0.27
chr3_187985246_187985463	0.29	LPP	LIM domain containing preferred translocation partner in lipoma	27702	0.23
chr17_26610027_26610178	0.29	ENSG00000207844	.	6523	0.1
chr3_156469526_156469677	0.29	TIPARP	TCDD-inducible poly(ADP-ribose) polymerase	70646	0.1
chr21_18145527_18145678	0.29	ENSG00000239023	.	54285	0.17
chr8_89288937_89289088	0.28	RP11-586K2.1		50053	0.16
chr12_52604417_52604648	0.28	KRT80	keratin 80	18748	0.1
chr9_21590451_21590602	0.28	MIR31HG	MIR31 host gene (non-protein coding)	30858	0.16
chr4_140958813_140959347	0.28	RP11-392B6.1		90089	0.09
chr1_199825379_199825530	0.28	ENSG00000200139	.	31833	0.23
chr14_94839858_94840009	0.28	SERPINA1	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1	14993	0.18
chr12_132267707_132268092	0.28	ENSG00000200516	.	18080	0.16
chr11_123089847_123089998	0.28	CLMP	CXADR-like membrane protein	23933	0.18
chr12_6332006_6332305	0.28	ENSG00000202318	.	11466	0.17
chr8_141734362_141734513	0.28	PTK2	protein tyrosine kinase 2	2550	0.32
chr4_169330808_169330959	0.28	DDX60L	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like	8754	0.24
chr11_108742969_108743120	0.28	ENSG00000201243	.	133200	0.05
chr10_95236478_95236629	0.28	MYOF	myoferlin	5398	0.21
chr4_126245178_126245329	0.28	FAT4	FAT atypical cadherin 4	7699	0.29
chr3_188067044_188067254	0.28	LPP	LIM domain containing preferred translocation partner in lipoma	109497	0.07
chr8_25771009_25771433	0.28	EBF2	early B-cell factor 2	25789	0.27
chr4_187597285_187597436	0.28	FAT1	FAT atypical cadherin 1	47649	0.17
chr3_17719701_17719852	0.28	ENSG00000271841	.	13321	0.25
chr12_107256430_107256581	0.28	RP11-144F15.1	Uncharacterized protein	87809	0.07
chr7_129304567_129304757	0.28	NRF1	nuclear respiratory factor 1	7471	0.24
chr2_48571922_48572463	0.28	ENSG00000251889	.	4227	0.27
chr14_52001291_52001686	0.28	ENSG00000252400	.	11906	0.22
chr21_39664180_39664501	0.28	KCNJ15	potassium inwardly-rectifying channel, subfamily J, member 15	4139	0.33
chr2_147739330_147739481	0.28	ENSG00000238860	.	342134	0.01
chr12_32748094_32748245	0.28	FGD4	FYVE, RhoGEF and PH domain containing 4	3291	0.33
chr11_114224456_114224725	0.28	RP11-64D24.2		2703	0.24
chr6_52382258_52382409	0.28	TRAM2	translocation associated membrane protein 2	59380	0.12
chr5_57483908_57484059	0.28	ENSG00000238899	.	117968	0.07
chr17_27574011_27574162	0.28	CRYBA1	crystallin, beta A1	205	0.94
chr7_18809523_18809674	0.28	ENSG00000222164	.	38304	0.21
chr14_78060038_78060870	0.28	SPTLC2	serine palmitoyltransferase, long chain base subunit 2	3210	0.25
chr7_77496191_77496692	0.28	PHTF2	putative homeodomain transcription factor 2	26944	0.18
chr1_98793274_98793457	0.28	ENSG00000221777	.	45576	0.21
chr1_202251770_202252122	0.28	ENSG00000239046	.	51154	0.1
chr15_60699546_60699697	0.28	ANXA2	annexin A2	4539	0.29
chr2_225955794_225955945	0.28	DOCK10	dedicator of cytokinesis 10	48710	0.18
chr8_67472669_67472820	0.28	MYBL1	v-myb avian myeloblastosis viral oncogene homolog-like 1	52398	0.1
chr13_76299059_76299210	0.28	LMO7	LIM domain 7	35369	0.19
chr5_86453164_86453315	0.27	ENSG00000265919	.	42468	0.15
chr13_76867098_76867386	0.27	ENSG00000243274	.	158175	0.04
chr7_80127442_80127593	0.27	GNAT3	guanine nucleotide binding protein, alpha transducing 3	13819	0.27
chr11_27407572_27407723	0.27	CCDC34	coiled-coil domain containing 34	22232	0.21
chr10_89435270_89435421	0.27	PAPSS2	3'-phosphoadenosine 5'-phosphosulfate synthase 2	14637	0.2
chr3_58034413_58034564	0.27	FLNB	filamin B, beta	29568	0.21
chr11_35606785_35606936	0.27	FJX1	four jointed box 1 (Drosophila)	32875	0.18
chr6_53389704_53389855	0.27	GCLC	glutamate-cysteine ligase, catalytic subunit	1657	0.39
chr9_83643160_83643311	0.27	ENSG00000221581	.	293991	0.01
chr2_55327280_55327923	0.27	ENSG00000266376	.	8245	0.2
chr9_134918134_134918364	0.27	MED27	mediator complex subunit 27	37004	0.2
chr11_130717130_130717402	0.27	SNX19	sorting nexin 19	46503	0.19
chr20_46815691_46815842	0.27	ENSG00000252227	.	51000	0.18
chr14_59804366_59804548	0.27	ENSG00000252869	.	62284	0.12
chr1_206164682_206164833	0.27	FAM72A	family with sequence similarity 72, member A	25846	0.15
chr1_157977722_157977873	0.27	KIRREL	kin of IRRE like (Drosophila)	14362	0.2
chr9_38026523_38026674	0.27	SHB	Src homology 2 domain containing adaptor protein B	42610	0.17
chr6_163777027_163777374	0.27	QKI	QKI, KH domain containing, RNA binding	58475	0.16
chr14_74724538_74725207	0.27	VSX2	visual system homeobox 2	18697	0.14
chr5_39072103_39073220	0.27	RICTOR	RPTOR independent companion of MTOR, complex 2	1830	0.43
chr20_11910800_11911092	0.27	BTBD3	BTB (POZ) domain containing 3	11447	0.24
chr10_4808545_4809063	0.27	AKR1E2	aldo-keto reductase family 1, member E2	20017	0.25
chr10_60462562_60462713	0.27	BICC1	bicaudal C homolog 1 (Drosophila)	90658	0.1
chr13_46074470_46074652	0.26	COG3	component of oligomeric golgi complex 3	35501	0.15
chr13_43843628_43843779	0.26	ENOX1	ecto-NOX disulfide-thiol exchanger 1	91510	0.1
chr5_14806397_14806548	0.26	ENSG00000264792	.	19649	0.23
chr1_51127497_51127778	0.26	FAF1	Fas (TNFRSF6) associated factor 1	49467	0.15
chr1_94269708_94269859	0.26	RP11-488P3.1		28783	0.16
chr12_120620090_120620241	0.26	ENSG00000263913	.	10235	0.11
chr9_16031215_16031463	0.26	C9orf92	chromosome 9 open reading frame 92	184558	0.03
chr1_87174228_87174695	0.26	SH3GLB1	SH3-domain GRB2-like endophilin B1	3883	0.2
chr17_40554278_40554429	0.26	ENSG00000221020	.	3326	0.15
chr4_159080194_159080345	0.26	FAM198B	family with sequence similarity 198, member B	564	0.76
chr3_99750954_99751105	0.26	ENSG00000264897	.	67787	0.11
chr3_11550931_11551082	0.26	VGLL4	vestigial like 4 (Drosophila)	59392	0.14
chr2_33589041_33589192	0.26	ENSG00000252246	.	31151	0.19

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of MSX1

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View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0071436	sodium ion export(GO:0071436)
0.1	0.3	GO:0060666	dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.1	0.3	GO:0048170	positive regulation of long-term neuronal synaptic plasticity(GO:0048170)
0.1	0.2	GO:0060426	lung vasculature development(GO:0060426)
0.1	0.2	GO:0051834	evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.1	0.3	GO:0045793	positive regulation of cell size(GO:0045793)
0.1	0.2	GO:0018343	protein farnesylation(GO:0018343)
0.1	0.2	GO:0060492	foregut regionalization(GO:0060423) lung field specification(GO:0060424) lung induction(GO:0060492)
0.1	0.3	GO:0097061	dendritic spine morphogenesis(GO:0060997) regulation of dendritic spine morphogenesis(GO:0061001) dendritic spine organization(GO:0097061)
0.1	0.3	GO:0007171	activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.1	0.2	GO:0007406	negative regulation of neuroblast proliferation(GO:0007406) negative regulation of neural precursor cell proliferation(GO:2000178)
0.1	0.2	GO:0019934	cGMP-mediated signaling(GO:0019934)
0.1	0.2	GO:0001778	plasma membrane repair(GO:0001778)
0.1	0.2	GO:0031340	positive regulation of vesicle fusion(GO:0031340)
0.1	0.2	GO:0051409	response to nitrosative stress(GO:0051409)
0.1	0.1	GO:0051176	positive regulation of sulfur metabolic process(GO:0051176)
0.0	0.2	GO:0007258	JUN phosphorylation(GO:0007258)
0.0	0.1	GO:1900115	sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.0	0.3	GO:0007185	transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0	0.2	GO:0010837	regulation of keratinocyte proliferation(GO:0010837)
0.0	0.1	GO:0001543	ovarian follicle rupture(GO:0001543)
0.0	0.1	GO:0002604	dendritic cell antigen processing and presentation(GO:0002468) regulation of dendritic cell antigen processing and presentation(GO:0002604) positive regulation of dendritic cell antigen processing and presentation(GO:0002606)
0.0	0.2	GO:0071277	cellular response to calcium ion(GO:0071277)
0.0	0.2	GO:0045091	regulation of single stranded viral RNA replication via double stranded DNA intermediate(GO:0045091)
0.0	0.1	GO:0017121	phospholipid scrambling(GO:0017121)
0.0	0.1	GO:0055098	response to low-density lipoprotein particle(GO:0055098)
0.0	0.1	GO:0045715	negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715)
0.0	0.2	GO:0045747	positive regulation of Notch signaling pathway(GO:0045747)
0.0	0.1	GO:0070098	chemokine-mediated signaling pathway(GO:0070098)
0.0	0.0	GO:0060435	bronchiole development(GO:0060435)
0.0	0.1	GO:0035385	Roundabout signaling pathway(GO:0035385)
0.0	0.1	GO:0048245	eosinophil chemotaxis(GO:0048245) eosinophil migration(GO:0072677)
0.0	0.1	GO:0046121	deoxyribonucleoside catabolic process(GO:0046121)
0.0	0.1	GO:0032486	Rap protein signal transduction(GO:0032486)
0.0	0.1	GO:0019372	lipoxygenase pathway(GO:0019372)
0.0	0.1	GO:0090081	regulation of heart induction by regulation of canonical Wnt signaling pathway(GO:0090081)
0.0	0.0	GO:0003215	cardiac right ventricle morphogenesis(GO:0003215)
0.0	0.1	GO:0010757	negative regulation of plasminogen activation(GO:0010757)
0.0	0.1	GO:0031659	regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle(GO:0031657) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle(GO:0031659)
0.0	0.2	GO:0008356	asymmetric cell division(GO:0008356)
0.0	0.1	GO:0071318	cellular response to ATP(GO:0071318)
0.0	0.1	GO:0060839	endothelial cell fate commitment(GO:0060839)
0.0	0.1	GO:0060841	venous blood vessel development(GO:0060841)
0.0	0.1	GO:0060638	mesenchymal-epithelial cell signaling(GO:0060638)
0.0	0.1	GO:0048149	behavioral response to ethanol(GO:0048149)
0.0	0.1	GO:0043578	nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0	0.1	GO:0048669	collateral sprouting in absence of injury(GO:0048669)
0.0	0.1	GO:0043615	astrocyte cell migration(GO:0043615)
0.0	0.2	GO:0000301	retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.0	0.1	GO:0060594	mammary gland specification(GO:0060594)
0.0	0.0	GO:0060028	convergent extension involved in axis elongation(GO:0060028)
0.0	0.2	GO:0060040	retinal bipolar neuron differentiation(GO:0060040)
0.0	0.1	GO:0042501	serine phosphorylation of STAT protein(GO:0042501)
0.0	0.1	GO:0003283	atrial septum development(GO:0003283) atrial septum morphogenesis(GO:0060413)
0.0	0.1	GO:0043569	negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.0	0.1	GO:0045077	negative regulation of interferon-gamma biosynthetic process(GO:0045077)
0.0	0.1	GO:0008300	isoprenoid catabolic process(GO:0008300)
0.0	0.1	GO:0033173	calcineurin-NFAT signaling cascade(GO:0033173)
0.0	0.1	GO:0050916	sensory perception of sweet taste(GO:0050916)
0.0	0.1	GO:0035426	extracellular matrix-cell signaling(GO:0035426)
0.0	0.1	GO:0035234	ectopic germ cell programmed cell death(GO:0035234)
0.0	0.1	GO:0072385	minus-end-directed organelle transport along microtubule(GO:0072385)
0.0	0.1	GO:0009414	response to water deprivation(GO:0009414)
0.0	0.1	GO:0014012	peripheral nervous system axon regeneration(GO:0014012)
0.0	0.1	GO:0060081	membrane hyperpolarization(GO:0060081)
0.0	0.1	GO:0010842	retina layer formation(GO:0010842)
0.0	0.1	GO:0009134	nucleoside diphosphate catabolic process(GO:0009134) ribonucleoside diphosphate catabolic process(GO:0009191)
0.0	0.0	GO:0034625	fatty acid elongation, monounsaturated fatty acid(GO:0034625)
0.0	0.2	GO:0006108	malate metabolic process(GO:0006108)
0.0	0.0	GO:0021631	optic nerve morphogenesis(GO:0021631)
0.0	0.0	GO:0072216	positive regulation of metanephros development(GO:0072216)
0.0	0.0	GO:0034067	protein localization to Golgi apparatus(GO:0034067)
0.0	0.1	GO:0006654	phosphatidic acid biosynthetic process(GO:0006654)
0.0	0.1	GO:0071731	response to nitric oxide(GO:0071731)
0.0	0.1	GO:0003032	detection of oxygen(GO:0003032)
0.0	0.1	GO:2000095	regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000095)
0.0	0.7	GO:0046847	filopodium assembly(GO:0046847)
0.0	0.2	GO:0015871	choline transport(GO:0015871)
0.0	0.1	GO:0042984	amyloid precursor protein biosynthetic process(GO:0042983) regulation of amyloid precursor protein biosynthetic process(GO:0042984)
0.0	0.1	GO:0046512	diol biosynthetic process(GO:0034312) sphingosine biosynthetic process(GO:0046512)
0.0	0.1	GO:0060457	negative regulation of digestive system process(GO:0060457)
0.0	0.1	GO:0009128	purine nucleoside monophosphate catabolic process(GO:0009128) ribonucleoside monophosphate catabolic process(GO:0009158) purine ribonucleoside monophosphate catabolic process(GO:0009169)
0.0	0.0	GO:0071072	negative regulation of phospholipid biosynthetic process(GO:0071072)
0.0	0.1	GO:2000757	negative regulation of histone acetylation(GO:0035067) negative regulation of protein acetylation(GO:1901984) negative regulation of peptidyl-lysine acetylation(GO:2000757)
0.0	0.1	GO:0010715	regulation of extracellular matrix disassembly(GO:0010715) negative regulation of extracellular matrix disassembly(GO:0010716) regulation of extracellular matrix organization(GO:1903053) negative regulation of extracellular matrix organization(GO:1903054)
0.0	0.1	GO:0007386	compartment pattern specification(GO:0007386)
0.0	0.1	GO:0008228	opsonization(GO:0008228)
0.0	0.0	GO:0060129	thyroid-stimulating hormone-secreting cell differentiation(GO:0060129)
0.0	0.0	GO:0007221	positive regulation of transcription of Notch receptor target(GO:0007221)
0.0	0.1	GO:0040037	negative regulation of fibroblast growth factor receptor signaling pathway(GO:0040037)
0.0	0.0	GO:0043589	skin morphogenesis(GO:0043589)
0.0	0.0	GO:0048807	female genitalia morphogenesis(GO:0048807)
0.0	0.0	GO:0071071	regulation of phospholipid biosynthetic process(GO:0071071)
0.0	0.2	GO:0031000	response to caffeine(GO:0031000)
0.0	0.1	GO:0009649	entrainment of circadian clock(GO:0009649)
0.0	0.1	GO:0006929	substrate-dependent cell migration(GO:0006929)
0.0	0.0	GO:0060592	mammary gland formation(GO:0060592) mammary placode formation(GO:0060596)
0.0	0.1	GO:0032467	positive regulation of cytokinesis(GO:0032467)
0.0	0.0	GO:0048670	regulation of collateral sprouting(GO:0048670)
0.0	0.0	GO:0060406	positive regulation of penile erection(GO:0060406)
0.0	0.0	GO:0010659	striated muscle cell apoptotic process(GO:0010658) cardiac muscle cell apoptotic process(GO:0010659) regulation of striated muscle cell apoptotic process(GO:0010662) negative regulation of striated muscle cell apoptotic process(GO:0010664) regulation of cardiac muscle cell apoptotic process(GO:0010665) negative regulation of cardiac muscle cell apoptotic process(GO:0010667)
0.0	0.1	GO:0033631	cell-cell adhesion mediated by integrin(GO:0033631)
0.0	0.0	GO:2000054	negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000054)
0.0	0.1	GO:0019367	fatty acid elongation, saturated fatty acid(GO:0019367)
0.0	0.0	GO:0060174	limb bud formation(GO:0060174)
0.0	0.1	GO:0033603	positive regulation of dopamine secretion(GO:0033603)
0.0	0.1	GO:0032462	regulation of protein homooligomerization(GO:0032462)
0.0	0.0	GO:0010966	regulation of phosphate transport(GO:0010966)
0.0	0.1	GO:0000103	sulfate assimilation(GO:0000103)
0.0	0.0	GO:0050942	positive regulation of melanocyte differentiation(GO:0045636) positive regulation of pigment cell differentiation(GO:0050942)
0.0	0.3	GO:0048008	platelet-derived growth factor receptor signaling pathway(GO:0048008)
0.0	0.0	GO:0036445	forebrain neuroblast division(GO:0021873) neuronal stem cell division(GO:0036445) neuroblast division(GO:0055057)
0.0	0.0	GO:2000649	regulation of sodium:proton antiporter activity(GO:0032415) regulation of sodium ion transmembrane transport(GO:1902305) regulation of sodium ion transmembrane transporter activity(GO:2000649)
0.0	0.1	GO:0035414	negative regulation of catenin import into nucleus(GO:0035414)
0.0	0.0	GO:0090200	positive regulation of mitochondrion organization(GO:0010822) positive regulation of release of cytochrome c from mitochondria(GO:0090200) positive regulation of apoptotic signaling pathway(GO:2001235)
0.0	0.1	GO:0031297	replication fork processing(GO:0031297)
0.0	0.2	GO:0046459	short-chain fatty acid metabolic process(GO:0046459)
0.0	0.0	GO:0009111	vitamin catabolic process(GO:0009111) fat-soluble vitamin catabolic process(GO:0042363)
0.0	0.1	GO:0002726	positive regulation of T cell cytokine production(GO:0002726)
0.0	0.0	GO:0003079	obsolete positive regulation of natriuresis(GO:0003079)
0.0	0.0	GO:0007132	meiotic metaphase I(GO:0007132)
0.0	0.0	GO:0060083	smooth muscle contraction involved in micturition(GO:0060083)
0.0	0.0	GO:0060528	secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.0	0.0	GO:0036037	CD8-positive, alpha-beta T cell activation(GO:0036037) CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0	0.0	GO:0060179	male courtship behavior(GO:0008049) male mating behavior(GO:0060179)
0.0	0.1	GO:0070584	mitochondrion morphogenesis(GO:0070584)
0.0	0.1	GO:0060438	trachea development(GO:0060438)
0.0	0.0	GO:0070091	glucagon secretion(GO:0070091) regulation of glucagon secretion(GO:0070092)
0.0	0.2	GO:0019321	pentose metabolic process(GO:0019321)
0.0	0.0	GO:0009448	gamma-aminobutyric acid metabolic process(GO:0009448)
0.0	0.0	GO:0007598	blood coagulation, extrinsic pathway(GO:0007598)
0.0	0.1	GO:1904893	negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0	0.0	GO:0046882	negative regulation of follicle-stimulating hormone secretion(GO:0046882)
0.0	0.0	GO:1901374	acetylcholine transport(GO:0015870) acetate ester transport(GO:1901374)
0.0	0.0	GO:0032227	negative regulation of synaptic transmission, dopaminergic(GO:0032227)
0.0	0.1	GO:0019985	translesion synthesis(GO:0019985)
0.0	0.0	GO:0032236	obsolete positive regulation of calcium ion transport via store-operated calcium channel activity(GO:0032236)
0.0	0.0	GO:0010891	negative regulation of sequestering of triglyceride(GO:0010891)
0.0	0.1	GO:0061384	heart trabecula formation(GO:0060347) heart trabecula morphogenesis(GO:0061384)
0.0	0.0	GO:2000008	regulation of protein localization to cell surface(GO:2000008)
0.0	0.2	GO:0007274	neuromuscular synaptic transmission(GO:0007274)
0.0	0.0	GO:0036072	intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.0	0.0	GO:0061525	hindgut morphogenesis(GO:0007442) hindgut development(GO:0061525)
0.0	0.0	GO:0010661	positive regulation of muscle cell apoptotic process(GO:0010661) positive regulation of smooth muscle cell apoptotic process(GO:0034393)
0.0	0.1	GO:0009200	deoxyribonucleoside triphosphate metabolic process(GO:0009200)
0.0	0.0	GO:0001996	positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996)
0.0	0.1	GO:0006527	arginine catabolic process(GO:0006527)
0.0	0.0	GO:0001672	regulation of chromatin assembly or disassembly(GO:0001672)
0.0	0.0	GO:0002385	innate immune response in mucosa(GO:0002227) mucosal immune response(GO:0002385)
0.0	0.0	GO:0001921	positive regulation of receptor recycling(GO:0001921)
0.0	0.1	GO:0032331	negative regulation of chondrocyte differentiation(GO:0032331)
0.0	0.1	GO:0090504	wound healing, spreading of epidermal cells(GO:0035313) wound healing, spreading of cells(GO:0044319) epiboly(GO:0090504) epiboly involved in wound healing(GO:0090505)
0.0	0.1	GO:0070934	CRD-mediated mRNA stabilization(GO:0070934)
0.0	0.1	GO:0007217	tachykinin receptor signaling pathway(GO:0007217)
0.0	0.1	GO:0007635	chemosensory behavior(GO:0007635)
0.0	0.0	GO:0002043	blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.0	0.0	GO:0032488	Cdc42 protein signal transduction(GO:0032488)
0.0	0.0	GO:0061302	smooth muscle cell-matrix adhesion(GO:0061302)
0.0	0.1	GO:0015014	heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.0	0.1	GO:0060013	righting reflex(GO:0060013)
0.0	0.1	GO:0009886	post-embryonic morphogenesis(GO:0009886)
0.0	0.0	GO:1902803	regulation of synaptic vesicle transport(GO:1902803) regulation of synaptic vesicle exocytosis(GO:2000300)
0.0	0.0	GO:0014848	urinary tract smooth muscle contraction(GO:0014848)
0.0	0.2	GO:0007026	negative regulation of microtubule depolymerization(GO:0007026)
0.0	0.0	GO:0050955	thermoception(GO:0050955)
0.0	0.0	GO:0061004	pattern specification involved in kidney development(GO:0061004) renal system pattern specification(GO:0072048) pattern specification involved in metanephros development(GO:0072268)
0.0	0.1	GO:0033327	Leydig cell differentiation(GO:0033327)
0.0	0.0	GO:0009756	carbohydrate mediated signaling(GO:0009756)
0.0	0.0	GO:0060449	bud elongation involved in lung branching(GO:0060449)
0.0	0.1	GO:0006072	glycerol-3-phosphate metabolic process(GO:0006072)
0.0	0.0	GO:0030091	protein repair(GO:0030091)
0.0	0.0	GO:0006210	pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) thymine metabolic process(GO:0019859)
0.0	0.0	GO:0051280	negative regulation of release of sequestered calcium ion into cytosol(GO:0051280) positive regulation of sequestering of calcium ion(GO:0051284) negative regulation of calcium ion transmembrane transport(GO:1903170)
0.0	0.2	GO:0034605	cellular response to heat(GO:0034605)
0.0	0.0	GO:0001992	regulation of systemic arterial blood pressure by vasopressin(GO:0001992)
0.0	0.0	GO:0031536	positive regulation of exit from mitosis(GO:0031536)
0.0	0.0	GO:0070254	mucus secretion(GO:0070254)
0.0	0.0	GO:0034063	stress granule assembly(GO:0034063)
0.0	0.0	GO:0051451	myoblast migration(GO:0051451)
0.0	0.0	GO:0030033	microvillus assembly(GO:0030033) microvillus organization(GO:0032528)
0.0	0.1	GO:0008611	ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
0.0	0.0	GO:0055094	response to lipoprotein particle(GO:0055094)
0.0	0.0	GO:0022605	oogenesis stage(GO:0022605)
0.0	0.1	GO:0034446	substrate adhesion-dependent cell spreading(GO:0034446)
0.0	0.0	GO:0048643	positive regulation of skeletal muscle tissue development(GO:0048643)
0.0	0.1	GO:0044341	sodium-dependent phosphate transport(GO:0044341)
0.0	0.0	GO:0009151	purine deoxyribonucleotide metabolic process(GO:0009151)
0.0	0.0	GO:0048087	positive regulation of developmental pigmentation(GO:0048087)
0.0	0.1	GO:0000768	syncytium formation by plasma membrane fusion(GO:0000768) myoblast fusion(GO:0007520)
0.0	0.0	GO:0010766	negative regulation of sodium ion transport(GO:0010766)
0.0	0.0	GO:0097435	extracellular fibril organization(GO:0043206) fibril organization(GO:0097435)
0.0	0.0	GO:0010936	negative regulation of macrophage cytokine production(GO:0010936)
0.0	0.0	GO:0019805	quinolinate biosynthetic process(GO:0019805)
0.0	0.0	GO:0001302	replicative cell aging(GO:0001302)
0.0	0.0	GO:0006388	RNA splicing, via endonucleolytic cleavage and ligation(GO:0000394) tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.0	0.0	GO:0097094	cranial suture morphogenesis(GO:0060363) craniofacial suture morphogenesis(GO:0097094)
0.0	0.1	GO:0016246	RNA interference(GO:0016246)
0.0	0.0	GO:0051005	negative regulation of lipoprotein lipase activity(GO:0051005)
0.0	0.1	GO:0043277	apoptotic cell clearance(GO:0043277)
0.0	0.0	GO:0045662	negative regulation of myoblast differentiation(GO:0045662)
0.0	0.0	GO:0070296	sarcoplasmic reticulum calcium ion transport(GO:0070296)
0.0	0.0	GO:0010896	regulation of triglyceride catabolic process(GO:0010896) positive regulation of triglyceride catabolic process(GO:0010898)
0.0	0.0	GO:0007500	mesodermal cell fate determination(GO:0007500)
0.0	0.1	GO:0021955	central nervous system neuron axonogenesis(GO:0021955)
0.0	0.1	GO:0001945	lymph vessel development(GO:0001945)
0.0	0.0	GO:0006498	N-terminal protein lipidation(GO:0006498)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0071437	invadopodium(GO:0071437)
0.0	0.1	GO:0042272	nuclear RNA export factor complex(GO:0042272)
0.0	0.1	GO:0071664	catenin-TCF7L2 complex(GO:0071664)
0.0	0.2	GO:0005915	zonula adherens(GO:0005915)
0.0	0.8	GO:0009925	basal plasma membrane(GO:0009925)
0.0	0.1	GO:0005588	collagen type V trimer(GO:0005588)
0.0	0.1	GO:0030934	anchoring collagen complex(GO:0030934)
0.0	0.2	GO:0031092	platelet alpha granule membrane(GO:0031092)
0.0	0.1	GO:0016533	cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.0	0.0	GO:0018995	host(GO:0018995) host cell part(GO:0033643) host intracellular part(GO:0033646) intracellular region of host(GO:0043656) host cell(GO:0043657) other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217)
0.0	0.1	GO:0033268	node of Ranvier(GO:0033268)
0.0	0.2	GO:0030315	T-tubule(GO:0030315)
0.0	0.1	GO:0044298	neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0	0.1	GO:0016327	apicolateral plasma membrane(GO:0016327)
0.0	0.1	GO:0043240	Fanconi anaemia nuclear complex(GO:0043240)
0.0	0.5	GO:0097517	stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0	0.1	GO:0060200	clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201)
0.0	0.1	GO:0098642	network-forming collagen trimer(GO:0098642) collagen network(GO:0098645)
0.0	0.1	GO:0070552	BRISC complex(GO:0070552)
0.0	0.1	GO:0070937	CRD-mediated mRNA stability complex(GO:0070937)
0.0	0.1	GO:0034993	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0	0.0	GO:0043259	laminin-10 complex(GO:0043259)
0.0	0.1	GO:0051233	spindle midzone(GO:0051233)
0.0	0.0	GO:0005899	insulin receptor complex(GO:0005899)
0.0	0.0	GO:0048179	activin receptor complex(GO:0048179)
0.0	0.1	GO:0031232	extrinsic component of external side of plasma membrane(GO:0031232)
0.0	0.1	GO:0005916	fascia adherens(GO:0005916)
0.0	0.1	GO:0008385	IkappaB kinase complex(GO:0008385)
0.0	0.1	GO:0030132	clathrin coat of coated pit(GO:0030132)
0.0	0.5	GO:0042734	presynaptic membrane(GO:0042734)
0.0	0.1	GO:0017146	NMDA selective glutamate receptor complex(GO:0017146)
0.0	0.1	GO:0005614	interstitial matrix(GO:0005614)
0.0	0.1	GO:0034464	BBSome(GO:0034464)
0.0	0.0	GO:0000214	tRNA-intron endonuclease complex(GO:0000214)
0.0	0.0	GO:0032133	chromosome passenger complex(GO:0032133)
0.0	0.1	GO:0046581	intercellular canaliculus(GO:0046581)
0.0	0.1	GO:0001917	photoreceptor inner segment(GO:0001917)
0.0	0.8	GO:0030027	lamellipodium(GO:0030027)
0.0	0.0	GO:0000176	nuclear exosome (RNase complex)(GO:0000176)
0.0	0.1	GO:0031588	nucleotide-activated protein kinase complex(GO:0031588)
0.0	0.1	GO:0000145	exocyst(GO:0000145)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0051371	muscle alpha-actinin binding(GO:0051371)
0.1	0.3	GO:0005173	stem cell factor receptor binding(GO:0005173)
0.1	0.3	GO:0005105	type 1 fibroblast growth factor receptor binding(GO:0005105)
0.1	0.2	GO:0030215	semaphorin receptor binding(GO:0030215)
0.1	0.3	GO:0005432	calcium:sodium antiporter activity(GO:0005432)
0.1	0.3	GO:0030297	transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.1	0.2	GO:0016909	JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.1	0.2	GO:0005010	insulin-like growth factor-activated receptor activity(GO:0005010)
0.1	0.2	GO:0045236	CXCR chemokine receptor binding(GO:0045236)
0.1	0.2	GO:0070053	thrombospondin receptor activity(GO:0070053)
0.0	0.2	GO:0004157	dihydropyrimidinase activity(GO:0004157)
0.0	0.2	GO:0048027	mRNA 5'-UTR binding(GO:0048027)
0.0	0.1	GO:0005006	epidermal growth factor-activated receptor activity(GO:0005006)
0.0	0.1	GO:0005229	intracellular calcium activated chloride channel activity(GO:0005229)
0.0	0.1	GO:0004045	aminoacyl-tRNA hydrolase activity(GO:0004045)
0.0	0.2	GO:0004470	malic enzyme activity(GO:0004470)
0.0	0.1	GO:0004995	tachykinin receptor activity(GO:0004995)
0.0	0.1	GO:0005294	neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.0	0.1	GO:0017128	phospholipid scramblase activity(GO:0017128)
0.0	0.1	GO:0050508	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.0	0.3	GO:0017166	vinculin binding(GO:0017166)
0.0	0.1	GO:0033130	acetylcholine receptor binding(GO:0033130)
0.0	0.2	GO:0004661	protein geranylgeranyltransferase activity(GO:0004661)
0.0	0.1	GO:0042805	actinin binding(GO:0042805)
0.0	0.2	GO:0017154	semaphorin receptor activity(GO:0017154)
0.0	0.2	GO:0005110	frizzled-2 binding(GO:0005110)
0.0	0.1	GO:0003680	AT DNA binding(GO:0003680)
0.0	0.1	GO:0008559	xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.0	0.1	GO:0045545	syndecan binding(GO:0045545)
0.0	0.2	GO:0016595	glutamate binding(GO:0016595)
0.0	0.1	GO:0002162	dystroglycan binding(GO:0002162)
0.0	0.1	GO:0004117	calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117)
0.0	0.0	GO:0005030	neurotrophin receptor activity(GO:0005030)
0.0	0.1	GO:0035198	miRNA binding(GO:0035198)
0.0	0.1	GO:0004370	glycerol kinase activity(GO:0004370)
0.0	0.1	GO:0009374	biotin binding(GO:0009374)
0.0	0.1	GO:0030548	acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
0.0	0.1	GO:0043522	leucine zipper domain binding(GO:0043522)
0.0	0.1	GO:0070290	N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0	0.1	GO:0050544	arachidonic acid binding(GO:0050544)
0.0	0.1	GO:0015220	choline transmembrane transporter activity(GO:0015220)
0.0	0.1	GO:0005152	interleukin-1 receptor antagonist activity(GO:0005152)
0.0	0.1	GO:0015204	urea transmembrane transporter activity(GO:0015204)
0.0	0.1	GO:0016454	serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0	0.1	GO:0017162	aryl hydrocarbon receptor binding(GO:0017162)
0.0	0.5	GO:0008093	cytoskeletal adaptor activity(GO:0008093)
0.0	0.1	GO:0000268	peroxisome targeting sequence binding(GO:0000268)
0.0	0.1	GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.0	0.1	GO:0004904	interferon receptor activity(GO:0004904)
0.0	0.1	GO:0008266	poly(U) RNA binding(GO:0008266)
0.0	0.1	GO:0005078	MAP-kinase scaffold activity(GO:0005078)
0.0	0.1	GO:0004791	thioredoxin-disulfide reductase activity(GO:0004791)
0.0	0.2	GO:0004859	phospholipase inhibitor activity(GO:0004859)
0.0	0.1	GO:0016774	phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.0	0.1	GO:0005521	lamin binding(GO:0005521)
0.0	0.1	GO:0008401	retinoic acid 4-hydroxylase activity(GO:0008401)
0.0	0.0	GO:0004167	dopachrome isomerase activity(GO:0004167)
0.0	0.1	GO:0003987	acetate-CoA ligase activity(GO:0003987)
0.0	0.1	GO:0016174	NAD(P)H oxidase activity(GO:0016174)
0.0	0.1	GO:0016635	oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor(GO:0016635)
0.0	0.1	GO:0004886	9-cis retinoic acid receptor activity(GO:0004886)
0.0	0.1	GO:0004645	phosphorylase activity(GO:0004645)
0.0	0.1	GO:0015280	ligand-gated sodium channel activity(GO:0015280)
0.0	0.2	GO:0043395	heparan sulfate proteoglycan binding(GO:0043395)
0.0	0.1	GO:0005148	prolactin receptor binding(GO:0005148)
0.0	0.1	GO:0043237	laminin-1 binding(GO:0043237)
0.0	0.1	GO:0003785	actin monomer binding(GO:0003785)
0.0	0.1	GO:0051920	peroxiredoxin activity(GO:0051920)
0.0	0.2	GO:0004312	fatty acid synthase activity(GO:0004312)
0.0	0.2	GO:0048407	platelet-derived growth factor binding(GO:0048407)
0.0	0.1	GO:0042834	peptidoglycan binding(GO:0042834)
0.0	0.0	GO:0004948	calcitonin receptor activity(GO:0004948)
0.0	0.2	GO:0032266	phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0	0.1	GO:0001085	RNA polymerase II transcription factor binding(GO:0001085)
0.0	0.1	GO:0005499	vitamin D binding(GO:0005499)
0.0	0.1	GO:0070008	serine-type exopeptidase activity(GO:0070008)
0.0	0.0	GO:0050501	hyaluronan synthase activity(GO:0050501)
0.0	0.0	GO:0008046	axon guidance receptor activity(GO:0008046)
0.0	0.0	GO:0045159	myosin II binding(GO:0045159)
0.0	0.0	GO:0008384	IkappaB kinase activity(GO:0008384)
0.0	0.0	GO:0070653	high-density lipoprotein particle receptor binding(GO:0070653)
0.0	0.1	GO:0031210	phosphatidylcholine binding(GO:0031210)
0.0	0.1	GO:0042153	obsolete RPTP-like protein binding(GO:0042153)
0.0	0.0	GO:0052659	inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658) inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity(GO:0052659)
0.0	0.2	GO:0004653	polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0	0.0	GO:0005111	type 2 fibroblast growth factor receptor binding(GO:0005111)
0.0	0.2	GO:0005523	tropomyosin binding(GO:0005523)
0.0	0.1	GO:0048020	CCR chemokine receptor binding(GO:0048020)
0.0	0.8	GO:0004714	transmembrane receptor protein tyrosine kinase activity(GO:0004714)
0.0	0.2	GO:0043498	obsolete cell surface binding(GO:0043498)
0.0	0.1	GO:0000339	RNA cap binding(GO:0000339)
0.0	0.1	GO:0000900	translation repressor activity, nucleic acid binding(GO:0000900)
0.0	0.0	GO:0004720	protein-lysine 6-oxidase activity(GO:0004720)
0.0	0.1	GO:0016413	O-acetyltransferase activity(GO:0016413)
0.0	0.1	GO:0008503	benzodiazepine receptor activity(GO:0008503)
0.0	0.1	GO:0004597	peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.0	0.1	GO:0048019	receptor inhibitor activity(GO:0030547) receptor antagonist activity(GO:0048019)
0.0	0.7	GO:0051015	actin filament binding(GO:0051015)
0.0	0.0	GO:0050543	icosatetraenoic acid binding(GO:0050543)
0.0	0.1	GO:0001515	opioid peptide activity(GO:0001515)
0.0	0.1	GO:0008253	5'-nucleotidase activity(GO:0008253)
0.0	0.1	GO:0001965	G-protein alpha-subunit binding(GO:0001965)
0.0	0.1	GO:0005172	vascular endothelial growth factor receptor binding(GO:0005172)
0.0	0.1	GO:0015385	sodium:proton antiporter activity(GO:0015385)
0.0	0.0	GO:0004307	ethanolaminephosphotransferase activity(GO:0004307)
0.0	0.1	GO:0016361	activin receptor activity, type I(GO:0016361)
0.0	0.1	GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.0	0.1	GO:0003960	NADPH:quinone reductase activity(GO:0003960)
0.0	0.2	GO:0004065	arylsulfatase activity(GO:0004065)
0.0	0.0	GO:0032450	maltose alpha-glucosidase activity(GO:0032450)
0.0	0.0	GO:0042978	ornithine decarboxylase activator activity(GO:0042978)
0.0	0.2	GO:0005212	structural constituent of eye lens(GO:0005212)
0.0	0.1	GO:0008526	phosphatidylinositol transporter activity(GO:0008526)
0.0	0.1	GO:0005000	vasopressin receptor activity(GO:0005000)
0.0	0.1	GO:0008157	protein phosphatase 1 binding(GO:0008157)
0.0	0.2	GO:0008603	cAMP-dependent protein kinase regulator activity(GO:0008603)
0.0	0.0	GO:0008502	melatonin receptor activity(GO:0008502)
0.0	0.1	GO:0016641	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641)
0.0	0.0	GO:0005315	inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0	0.0	GO:0045294	alpha-catenin binding(GO:0045294)
0.0	0.0	GO:0003896	DNA primase activity(GO:0003896)
0.0	0.1	GO:0003689	DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0	0.0	GO:0016933	extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.0	0.2	GO:0005242	inward rectifier potassium channel activity(GO:0005242)
0.0	0.1	GO:0001609	G-protein coupled adenosine receptor activity(GO:0001609)
0.0	0.1	GO:0004957	prostaglandin E receptor activity(GO:0004957)
0.0	0.1	GO:0047429	nucleoside-triphosphate diphosphatase activity(GO:0047429)
0.0	0.0	GO:0016149	translation release factor activity, codon specific(GO:0016149)
0.0	0.1	GO:0035259	glucocorticoid receptor binding(GO:0035259)
0.0	0.1	GO:0004749	ribose phosphate diphosphokinase activity(GO:0004749)
0.0	0.0	GO:0008252	nucleotidase activity(GO:0008252)
0.0	0.1	GO:0030306	ADP-ribosylation factor binding(GO:0030306)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.1	PID MYC PATHWAY	C-MYC pathway
0.0	0.0	PID GLYPICAN 1PATHWAY	Glypican 1 network
0.0	0.1	ST TYPE I INTERFERON PATHWAY	Type I Interferon (alpha/beta IFN) Pathway
0.0	1.0	PID ECADHERIN STABILIZATION PATHWAY	Stabilization and expansion of the E-cadherin adherens junction
0.0	0.2	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
0.0	0.2	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.0	0.0	PID ECADHERIN KERATINOCYTE PATHWAY	E-cadherin signaling in keratinocytes
0.0	0.4	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
0.0	0.0	ST INTERLEUKIN 4 PATHWAY	Interleukin 4 (IL-4) Pathway
0.0	0.0	PID FAK PATHWAY	Signaling events mediated by focal adhesion kinase
0.0	0.0	PID CD8 TCR DOWNSTREAM PATHWAY	Downstream signaling in naïve CD8+ T cells
0.0	0.3	PID NECTIN PATHWAY	Nectin adhesion pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.5	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.0	0.0	REACTOME REGULATION OF APOPTOSIS	Genes involved in Regulation of Apoptosis
0.0	0.0	REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0	Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
0.0	0.3	REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	Genes involved in DCC mediated attractive signaling
0.0	0.3	REACTOME CRMPS IN SEMA3A SIGNALING	Genes involved in CRMPs in Sema3A signaling
0.0	0.2	REACTOME GAP JUNCTION DEGRADATION	Genes involved in Gap junction degradation
0.0	0.0	REACTOME SOS MEDIATED SIGNALLING	Genes involved in SOS-mediated signalling
0.0	0.2	REACTOME PYRIMIDINE CATABOLISM	Genes involved in Pyrimidine catabolism
0.0	0.0	REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS	Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0	0.2	REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING	Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0	0.4	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.0	0.3	REACTOME HS GAG DEGRADATION	Genes involved in HS-GAG degradation
0.0	0.1	REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION	Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0	0.2	REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN	Genes involved in Platelet Adhesion to exposed collagen
0.0	0.4	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.0	0.0	REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY	Genes involved in Regulation of the Fanconi anemia pathway
0.0	0.2	REACTOME HYALURONAN METABOLISM	Genes involved in Hyaluronan metabolism
0.0	0.1	REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS	Genes involved in Activation of the AP-1 family of transcription factors
0.0	0.0	REACTOME PKB MEDIATED EVENTS	Genes involved in PKB-mediated events
0.0	0.1	REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	Genes involved in Ionotropic activity of Kainate Receptors
0.0	0.0	REACTOME PD1 SIGNALING	Genes involved in PD-1 signaling
0.0	0.3	REACTOME GLUTATHIONE CONJUGATION	Genes involved in Glutathione conjugation
0.0	0.1	REACTOME ADP SIGNALLING THROUGH P2RY12	Genes involved in ADP signalling through P2Y purinoceptor 12
0.0	0.1	REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK	Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0	0.2	REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS	Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0	0.0	REACTOME ADP SIGNALLING THROUGH P2RY1	Genes involved in ADP signalling through P2Y purinoceptor 1
0.0	0.1	REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.0	0.1	REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR	Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0	0.1	REACTOME PYRIMIDINE METABOLISM	Genes involved in Pyrimidine metabolism
0.0	0.0	REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION	Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion