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ENCODE: H3K4me1 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for MSX2

Z-value: 1.03

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Transcription factors associated with MSX2

Gene Symbol	Gene ID	Gene Info
MSX2 Ensembl NCBI GeneCards UniProt	ENSG00000120149.7	MSX2

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
MSX2	chr5_174151057_174151248	384	0.906182	0.81	8.5e-03	Click!
MSX2	chr5_173916383_173916534	235078	0.019896	-0.69	3.8e-02	Click!
MSX2	chr5_173918124_173918275	233337	0.020178	-0.69	4.1e-02	Click!
MSX2	chr5_173888101_173888252	263360	0.016023	0.67	4.6e-02	Click!
MSX2	chr5_173882231_173882382	269230	0.015351	0.67	4.6e-02	Click!

Activity of the MSX2 motif across conditions

Conditions sorted by the z-value of the MSX2 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr17_64419641_64419918	0.70	RP11-4F22.2		6807	0.26
chr18_59619334_59619485	0.65	RNF152	ring finger protein 152	57945	0.16
chr3_17274716_17274867	0.60	ENSG00000252976	.	97577	0.08
chr2_235231609_235231760	0.56	ARL4C	ADP-ribosylation factor-like 4C	173560	0.03
chr7_150635354_150635936	0.53	KCNH2	potassium voltage-gated channel, subfamily H (eag-related), member 2	17349	0.15
chr14_99720519_99720759	0.47	AL109767.1		8646	0.22
chr10_98301601_98301752	0.47	TLL2	tolloid-like 2	28008	0.18
chr22_19463070_19463221	0.44	UFD1L	ubiquitin fusion degradation 1 like (yeast)	3309	0.13
chr12_112779348_112779499	0.44	HECTD4	HECT domain containing E3 ubiquitin protein ligase 4	40473	0.14
chr11_20135030_20135181	0.42	NAV2-AS1	NAV2 antisense RNA 1	7073	0.24
chrX_107068310_107068461	0.42	MID2	midline 2	600	0.75
chr1_180549413_180549564	0.41	ENSG00000266683	.	34520	0.16
chr3_9445704_9445855	0.41	SETD5-AS1	SETD5 antisense RNA 1	5516	0.16
chr15_81248608_81248759	0.41	KIAA1199	KIAA1199	22916	0.14
chr5_142562188_142562394	0.40	ARHGAP26-IT1	ARHGAP26 intronic transcript 1 (non-protein coding)	9774	0.25
chr6_3159984_3160135	0.39	TUBB2A	tubulin, beta 2A class IIa	2299	0.23
chr1_92019254_92019429	0.39	CDC7	cell division cycle 7	52646	0.17
chr5_96000301_96000453	0.39	CAST	calpastatin	1620	0.38
chr15_50648645_50649024	0.39	ENSG00000244879	.	166	0.9
chr16_50219117_50219379	0.38	PAPD5	PAP associated domain containing 5	31469	0.14
chr12_95196881_95197032	0.37	ENSG00000208038	.	31218	0.23
chr2_23603358_23603509	0.37	KLHL29	kelch-like family member 29	4655	0.35
chr19_31557220_31557371	0.37	AC020952.1	Uncharacterized protein	83067	0.11
chr14_75672848_75673038	0.36	ENSG00000252013	.	4071	0.19
chr10_96161826_96161977	0.36	TBC1D12	TBC1 domain family, member 12	360	0.9
chr1_181121299_181121450	0.36	IER5	immediate early response 5	63736	0.13
chr20_62042443_62042594	0.36	RP11-358D14.2		36886	0.09
chr5_140998829_140999245	0.36	DIAPH1	diaphanous-related formin 1	415	0.66
chr3_160940381_160941002	0.35	NMD3	NMD3 ribosome export adaptor	1344	0.59
chr1_172644665_172644877	0.35	FASLG	Fas ligand (TNF superfamily, member 6)	16613	0.25
chr16_67618812_67618963	0.35	CTCF	CCCTC-binding factor (zinc finger protein)	22577	0.08
chr11_117917434_117917585	0.35	ENSG00000272075	.	20443	0.14
chr22_20226344_20226543	0.35	RTN4R	reticulon 4 receptor	4764	0.15
chrX_106928490_106928775	0.35	TSC22D3	TSC22 domain family, member 3	30999	0.18
chr5_39231622_39231809	0.34	FYB	FYN binding protein	12007	0.28
chr20_57231559_57231809	0.34	STX16	syntaxin 16	4621	0.19
chr10_130706677_130706967	0.34	MGMT	O-6-methylguanine-DNA methyltransferase	558626	0.0
chr15_60871759_60871981	0.33	RORA	RAR-related orphan receptor A	12870	0.21
chr2_99954705_99955291	0.33	EIF5B	eukaryotic translation initiation factor 5B	1182	0.4
chr2_119188712_119188863	0.33	INSIG2	insulin induced gene 2	342737	0.01
chr15_48251538_48251689	0.33	SLC24A5	solute carrier family 24 (sodium/potassium/calcium exchanger), member 5	161556	0.03
chr6_112306754_112307040	0.33	WISP3	WNT1 inducible signaling pathway protein 3	68378	0.11
chr6_119227091_119227242	0.32	ASF1A	anti-silencing function 1A histone chaperone	11782	0.19
chr18_60458887_60459075	0.32	AC015989.1	Uncharacterized protein	32442	0.17
chr3_122048704_122048855	0.32	CSTA	cystatin A (stefin A)	4670	0.19
chr8_71124474_71124716	0.32	NCOA2	nuclear receptor coactivator 2	33015	0.21
chr4_99563113_99563379	0.32	TSPAN5	tetraspanin 5	15540	0.22
chr4_110483700_110484182	0.32	CCDC109B	coiled-coil domain containing 109B	1795	0.42
chr17_47440332_47440604	0.32	ZNF652	zinc finger protein 652	633	0.61
chr9_20320271_20320422	0.31	ENSG00000221744	.	25344	0.21
chr10_33425697_33425907	0.31	ENSG00000263576	.	38238	0.16
chr14_52795656_52796058	0.31	PTGER2	prostaglandin E receptor 2 (subtype EP2), 53kDa	14744	0.25
chr12_74884186_74884337	0.31	ATXN7L3B	ataxin 7-like 3B	47290	0.17
chr14_53158829_53159146	0.31	ERO1L	ERO1-like (S. cerevisiae)	3260	0.21
chr2_62806762_62807072	0.30	TMEM17	transmembrane protein 17	73441	0.1
chr1_12291292_12291653	0.30	VPS13D	vacuolar protein sorting 13 homolog D (S. cerevisiae)	1348	0.41
chr6_139492633_139492784	0.30	HECA	headcase homolog (Drosophila)	36459	0.17
chr2_202297300_202297558	0.30	TRAK2	trafficking protein, kinesin binding 2	848	0.59
chr9_20490846_20490997	0.30	ENSG00000264941	.	11419	0.23
chr8_144097895_144098282	0.30	LY6E	lymphocyte antigen 6 complex, locus E	1311	0.42
chr10_29772721_29772872	0.29	SVIL	supervillin	12651	0.23
chr17_62180290_62180441	0.29	ERN1	endoplasmic reticulum to nucleus signaling 1	27120	0.14
chr7_73265347_73265568	0.29	WBSCR27	Williams Beuren syndrome chromosome region 27	8592	0.15
chr5_36949315_36949466	0.29	NIPBL	Nipped-B homolog (Drosophila)	72498	0.13
chr4_10107887_10108195	0.29	ENSG00000223086	.	9467	0.16
chr14_65380506_65380744	0.29	CHURC1	churchill domain containing 1	454	0.38
chr17_63031973_63032289	0.29	RP11-583F2.5		15896	0.16
chr7_156809109_156809289	0.29	MNX1-AS1	MNX1 antisense RNA 1 (head to head)	5700	0.18
chr20_37165542_37165693	0.29	ENSG00000263473	.	20411	0.13
chr8_25033335_25033486	0.29	ENSG00000241811	.	5825	0.25
chr16_4674083_4674234	0.29	MGRN1	mahogunin ring finger 1, E3 ubiquitin protein ligase	633	0.59
chr3_183544116_183544267	0.28	MAP6D1	MAP6 domain containing 1	809	0.53
chr5_140934914_140935065	0.28	CTD-2024I7.13		2889	0.17
chr15_83733229_83733380	0.28	BTBD1	BTB (POZ) domain containing 1	2599	0.17
chr20_56969877_56970028	0.28	VAPB	VAMP (vesicle-associated membrane protein)-associated protein B and C	5583	0.26
chr1_112491159_112491310	0.28	KCND3	potassium voltage-gated channel, Shal-related subfamily, member 3	34184	0.17
chr9_33431365_33431516	0.28	AQP3	aquaporin 3 (Gill blood group)	16169	0.14
chr12_105956829_105956980	0.28	C12orf75	chromosome 12 open reading frame 75	232258	0.02
chr1_193428730_193429035	0.28	ENSG00000252241	.	272192	0.01
chr2_228735932_228736236	0.28	DAW1	dynein assembly factor with WDR repeat domains 1	239	0.94
chr6_139482795_139483056	0.28	HECA	headcase homolog (Drosophila)	26676	0.21
chr12_64798932_64799366	0.28	XPOT	exportin, tRNA	323	0.88
chr13_53027549_53027700	0.28	CKAP2	cytoskeleton associated protein 2	1940	0.3
chr8_120219756_120219907	0.28	MAL2	mal, T-cell differentiation protein 2 (gene/pseudogene)	779	0.76
chr1_172149548_172149911	0.28	DNM3OS	DNM3 opposite strand/antisense RNA	35795	0.15
chr3_119015914_119016065	0.28	ARHGAP31	Rho GTPase activating protein 31	2769	0.24
chr6_35149420_35149571	0.27	SCUBE3	signal peptide, CUB domain, EGF-like 3	32695	0.14
chr4_88929574_88929774	0.27	PKD2	polycystic kidney disease 2 (autosomal dominant)	854	0.61
chr5_170763650_170763947	0.27	ENSG00000265740	.	22323	0.14
chr5_95294789_95295005	0.27	ELL2	elongation factor, RNA polymerase II, 2	2655	0.26
chr3_156478754_156479058	0.27	LEKR1	leucine, glutamate and lysine rich 1	65183	0.12
chr14_66404533_66404789	0.27	CTD-2014B16.3	Uncharacterized protein	66580	0.13
chr18_46918320_46918471	0.27	DYM	dymeclin	13376	0.18
chr13_26475136_26475287	0.27	AL138815.2	Uncharacterized protein	22532	0.17
chr22_36232750_36232901	0.27	RBFOX2	RNA binding protein, fox-1 homolog (C. elegans) 2	3440	0.35
chr5_40511051_40511202	0.26	ENSG00000199552	.	143939	0.04
chr15_42352123_42352335	0.26	PLA2G4E	phospholipase A2, group IVE	8841	0.16
chr22_32046621_32046810	0.26	PISD	phosphatidylserine decarboxylase	11451	0.2
chr2_148804260_148804811	0.26	ORC4	origin recognition complex, subunit 4	25388	0.19
chr22_40654247_40654479	0.26	TNRC6B	trinucleotide repeat containing 6B	6644	0.26
chr16_70097897_70098048	0.26	PDXDC2P		1707	0.31
chr1_100889654_100889805	0.26	ENSG00000216067	.	45398	0.13
chr6_73135306_73135457	0.26	RIMS1	regulating synaptic membrane exocytosis 1	58949	0.16
chr21_19188629_19188846	0.26	C21orf91	chromosome 21 open reading frame 91	2599	0.3
chr1_116185862_116186059	0.26	VANGL1	VANGL planar cell polarity protein 1	710	0.71
chr4_39364717_39364868	0.26	RFC1	replication factor C (activator 1) 1, 145kDa	3177	0.21
chr8_87524414_87524565	0.26	RMDN1	regulator of microtubule dynamics 1	2078	0.28
chrX_16661091_16661259	0.26	S100G	S100 calcium binding protein G	7106	0.18
chr8_91783068_91783219	0.26	NECAB1	N-terminal EF-hand calcium binding protein 1	20635	0.19
chr9_5531438_5531729	0.26	PDCD1LG2	programmed cell death 1 ligand 2	21013	0.22
chr11_2966895_2967126	0.25	PHLDA2	pleckstrin homology-like domain, family A, member 2	16325	0.11
chr15_34873680_34873831	0.25	GOLGA8B	golgin A8 family, member B	2016	0.29
chr14_69238852_69239003	0.25	ZFP36L1	ZFP36 ring finger protein-like 1	19033	0.19
chr9_118131626_118131777	0.25	DEC1	deleted in esophageal cancer 1	227604	0.02
chr1_10569828_10570301	0.25	PEX14	peroxisomal biogenesis factor 14	35025	0.11
chr14_76605047_76605198	0.25	GPATCH2L	G patch domain containing 2-like	13140	0.26
chr5_150644691_150644842	0.25	GM2A	GM2 ganglioside activator	5406	0.2
chr2_31440406_31440557	0.25	CAPN14	calpain 14	70	0.97
chr18_33647690_33647852	0.25	RPRD1A	regulation of nuclear pre-mRNA domain containing 1A	232	0.94
chr6_4804997_4805148	0.25	CDYL	chromodomain protein, Y-like	28403	0.2
chr17_39874084_39874250	0.25	ENSG00000201920	.	239	0.85
chr2_143918611_143918880	0.25	RP11-190J23.1		10996	0.25
chr11_82617435_82617696	0.25	C11orf82	chromosome 11 open reading frame 82	2735	0.27
chr13_99867467_99867663	0.25	ENSG00000201793	.	9603	0.19
chr3_142296047_142296384	0.25	ATR	ataxia telangiectasia and Rad3 related	1453	0.37
chr3_132137362_132137693	0.24	DNAJC13	DnaJ (Hsp40) homolog, subfamily C, member 13	1157	0.6
chr11_14378772_14379652	0.24	RRAS2	related RAS viral (r-ras) oncogene homolog 2	819	0.73
chr8_61918765_61918944	0.24	CLVS1	clavesin 1	50863	0.18
chr17_41668721_41668956	0.24	ETV4	ets variant 4	11850	0.16
chr8_110987376_110987527	0.24	KCNV1	potassium channel, subfamily V, member 1	492	0.75
chr9_100744268_100744520	0.24	ANP32B	acidic (leucine-rich) nuclear phosphoprotein 32 family, member B	1249	0.39
chr1_223084470_223084621	0.24	ENSG00000239054	.	744	0.72
chr6_48037013_48037164	0.24	PTCHD4	patched domain containing 4	663	0.83
chr16_85369002_85369321	0.24	RP11-680G10.1	Uncharacterized protein	21908	0.2
chr6_37665777_37665940	0.24	MDGA1	MAM domain containing glycosylphosphatidylinositol anchor 1	92	0.98
chr12_104329327_104329478	0.24	ENSG00000265072	.	5199	0.15
chr5_54605298_54605894	0.24	SKIV2L2	superkiller viralicidic activity 2-like 2 (S. cerevisiae)	1767	0.29
chr14_63940495_63940646	0.24	ENSG00000252463	.	3922	0.18
chr1_171702173_171702324	0.24	VAMP4	vesicle-associated membrane protein 4	8954	0.19
chr12_50580729_50580880	0.24	RP3-405J10.3		4342	0.14
chr17_48618789_48619185	0.24	ENSG00000250286	.	2872	0.13
chr3_15687980_15688217	0.24	BTD	biotinidase	44622	0.11
chr17_64644644_64644795	0.24	ENSG00000251698	.	9332	0.19
chr4_38092282_38092433	0.24	TBC1D1	TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1	44865	0.19
chr5_55911226_55911525	0.24	AC022431.2	Homo sapiens uncharacterized LOC101928448 (LOC101928448), mRNA.	9316	0.26
chr12_51015541_51015966	0.24	ENSG00000207136	.	11303	0.21
chr5_141503692_141503877	0.23	NDFIP1	Nedd4 family interacting protein 1	15714	0.23
chr7_23036448_23036599	0.23	FAM126A	family with sequence similarity 126, member A	17170	0.24
chr2_228275751_228276175	0.23	TM4SF20	transmembrane 4 L six family member 20	29252	0.16
chr3_45209403_45209586	0.23	CDCP1	CUB domain containing protein 1	21580	0.2
chr18_2588153_2588403	0.23	NDC80	NDC80 kinetochore complex component	10430	0.14
chr3_30664719_30665032	0.23	TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	16782	0.27
chr7_99005041_99005202	0.23	BUD31	BUD31 homolog (S. cerevisiae)	1143	0.26
chr1_10555616_10555775	0.23	PEX14	peroxisomal biogenesis factor 14	20656	0.12
chr2_238787700_238787851	0.23	ENSG00000263723	.	9228	0.2
chr2_101171486_101171889	0.23	ENSG00000266005	.	825	0.59
chr15_89170331_89170558	0.23	AEN	apoptosis enhancing nuclease	5843	0.16
chr8_128412696_128412847	0.23	POU5F1B	POU class 5 homeobox 1B	13764	0.24
chr4_146102106_146102613	0.23	OTUD4	OTU domain containing 4	1046	0.59
chr10_105525632_105525787	0.23	SH3PXD2A	SH3 and PX domains 2A	35346	0.17
chr9_32524416_32524567	0.23	DDX58	DEAD (Asp-Glu-Ala-Asp) box polypeptide 58	1702	0.32
chr11_14375636_14375787	0.23	RRAS2	related RAS viral (r-ras) oncogene homolog 2	335	0.93
chr21_46496959_46497110	0.23	ADARB1	adenosine deaminase, RNA-specific, B1	2519	0.22
chr14_103270514_103270708	0.23	ENSG00000238853	.	14683	0.17
chr2_10025449_10025600	0.23	TAF1B	TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa	9397	0.23
chr3_152888395_152888546	0.23	RAP2B	RAP2B, member of RAS oncogene family	8441	0.21
chr4_36396689_36396840	0.23	RP11-431M7.2		2732	0.4
chr1_175139081_175139232	0.23	KIAA0040	KIAA0040	22734	0.22
chr1_235406790_235406941	0.23	ARID4B	AT rich interactive domain 4B (RBP1-like)	29634	0.16
chr7_29605198_29605734	0.23	PRR15	proline rich 15	400	0.84
chr14_92973076_92973375	0.23	RIN3	Ras and Rab interactor 3	6893	0.29
chr6_106590141_106590398	0.23	RP1-134E15.3		42254	0.16
chr2_99095585_99095903	0.22	INPP4A	inositol polyphosphate-4-phosphatase, type I, 107kDa	34331	0.18
chr7_45962099_45962436	0.22	IGFBP3	insulin-like growth factor binding protein 3	794	0.65
chr1_3619930_3620081	0.22	TP73	tumor protein p73	5383	0.13
chr5_64919668_64919819	0.22	TRIM23	tripartite motif containing 23	380	0.59
chr1_24971768_24971919	0.22	SRRM1	serine/arginine repetitive matrix 1	1793	0.32
chr3_16522193_16522470	0.22	RFTN1	raftlin, lipid raft linker 1	2041	0.43
chr7_4819835_4819986	0.22	AP5Z1	adaptor-related protein complex 5, zeta 1 subunit	4646	0.17
chr2_145081239_145081390	0.22	GTDC1	glycosyltransferase-like domain containing 1	3877	0.36
chr10_71981169_71981370	0.22	PPA1	pyrophosphatase (inorganic) 1	11891	0.2
chr7_100477718_100477869	0.22	SRRT	serrate RNA effector molecule homolog (Arabidopsis)	4782	0.1
chr10_35050362_35050513	0.22	PARD3	par-3 family cell polarity regulator	53812	0.14
chr19_39686992_39687200	0.22	NCCRP1	non-specific cytotoxic cell receptor protein 1 homolog (zebrafish)	505	0.69
chr4_39638786_39639138	0.22	SMIM14	small integral membrane protein 14	1551	0.38
chr8_58807157_58807308	0.22	FAM110B	family with sequence similarity 110, member B	99881	0.09
chr11_34948593_34948744	0.22	PDHX	pyruvate dehydrogenase complex, component X	10480	0.19
chr16_27185640_27185898	0.22	KDM8	lysine (K)-specific demethylase 8	29038	0.17
chr13_74644571_74644841	0.22	KLF12	Kruppel-like factor 12	63688	0.15
chr11_96059054_96059205	0.22	ENSG00000266192	.	15473	0.19
chr2_235401803_235401954	0.22	ARL4C	ADP-ribosylation factor-like 4C	3366	0.4
chr16_3865090_3865241	0.22	CREBBP	CREB binding protein	34297	0.17
chr17_17640963_17641296	0.22	RAI1-AS1	RAI1 antisense RNA 1	33006	0.11
chr5_114504885_114505107	0.21	TRIM36	tripartite motif containing 36	610	0.73
chr3_128601669_128601820	0.21	ACAD9	acyl-CoA dehydrogenase family, member 9	3272	0.23
chr5_133389529_133390012	0.21	VDAC1	voltage-dependent anion channel 1	48946	0.13
chr10_131583616_131583767	0.21	EBF3	early B-cell factor 3	56744	0.14
chr10_63603062_63603213	0.21	ARID5B	AT rich interactive domain 5B (MRF1-like)	57922	0.14
chr2_197084220_197084574	0.21	ENSG00000239161	.	4351	0.23
chr3_71686752_71686903	0.21	FOXP1	forkhead box P1	53687	0.13

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of MSX2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0051138	NK T cell differentiation(GO:0001865) regulation of NK T cell differentiation(GO:0051136) positive regulation of NK T cell differentiation(GO:0051138)
0.1	0.2	GO:0010761	fibroblast migration(GO:0010761)
0.1	0.1	GO:0051284	negative regulation of release of sequestered calcium ion into cytosol(GO:0051280) positive regulation of sequestering of calcium ion(GO:0051284) negative regulation of calcium ion transmembrane transport(GO:1903170)
0.1	0.2	GO:0070266	necroptotic process(GO:0070266) programmed necrotic cell death(GO:0097300)
0.1	0.2	GO:0045875	negative regulation of sister chromatid cohesion(GO:0045875)
0.1	0.2	GO:0034214	protein hexamerization(GO:0034214)
0.0	0.1	GO:0071481	cellular response to X-ray(GO:0071481)
0.0	0.2	GO:0043374	CD8-positive, alpha-beta T cell activation(GO:0036037) CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0	0.3	GO:0060037	pharyngeal system development(GO:0060037)
0.0	0.2	GO:0043951	negative regulation of cAMP-mediated signaling(GO:0043951)
0.0	0.1	GO:0070295	renal water absorption(GO:0070295)
0.0	0.2	GO:0003323	type B pancreatic cell development(GO:0003323)
0.0	0.1	GO:0010508	positive regulation of autophagy(GO:0010508)
0.0	0.1	GO:0070141	response to UV-A(GO:0070141)
0.0	0.1	GO:0060999	positive regulation of dendritic spine development(GO:0060999)
0.0	0.2	GO:0016246	RNA interference(GO:0016246)
0.0	0.1	GO:0001672	regulation of chromatin assembly or disassembly(GO:0001672)
0.0	0.0	GO:0033689	negative regulation of osteoblast proliferation(GO:0033689)
0.0	0.1	GO:0006498	N-terminal protein lipidation(GO:0006498)
0.0	0.2	GO:0035414	negative regulation of catenin import into nucleus(GO:0035414)
0.0	0.1	GO:0060666	dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.0	0.2	GO:0045898	regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0	0.3	GO:0021527	spinal cord association neuron differentiation(GO:0021527)
0.0	0.1	GO:0032486	Rap protein signal transduction(GO:0032486)
0.0	0.2	GO:0007172	signal complex assembly(GO:0007172)
0.0	0.1	GO:0009296	obsolete flagellum assembly(GO:0009296)
0.0	0.1	GO:2000171	negative regulation of dendrite development(GO:2000171)
0.0	0.1	GO:0061029	eyelid development in camera-type eye(GO:0061029)
0.0	0.1	GO:0006065	UDP-glucuronate biosynthetic process(GO:0006065)
0.0	0.1	GO:0018343	protein farnesylation(GO:0018343)
0.0	0.1	GO:0071436	sodium ion export(GO:0071436)
0.0	0.1	GO:0072131	kidney mesenchyme morphogenesis(GO:0072131) metanephric mesenchyme morphogenesis(GO:0072133)
0.0	0.1	GO:0045722	positive regulation of gluconeogenesis(GO:0045722)
0.0	0.2	GO:0007520	myoblast fusion(GO:0007520)
0.0	0.1	GO:0019605	butyrate metabolic process(GO:0019605)
0.0	0.1	GO:0042149	cellular response to glucose starvation(GO:0042149)
0.0	0.2	GO:0032456	endocytic recycling(GO:0032456)
0.0	0.1	GO:0060539	diaphragm development(GO:0060539)
0.0	0.1	GO:0060836	lymphatic endothelial cell differentiation(GO:0060836)
0.0	0.1	GO:0034139	regulation of toll-like receptor 3 signaling pathway(GO:0034139)
0.0	0.0	GO:0070602	centromeric sister chromatid cohesion(GO:0070601) regulation of centromeric sister chromatid cohesion(GO:0070602)
0.0	0.2	GO:0048242	epinephrine transport(GO:0048241) epinephrine secretion(GO:0048242)
0.0	0.1	GO:0030488	tRNA methylation(GO:0030488)
0.0	0.1	GO:0072386	plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.0	0.1	GO:0016576	histone dephosphorylation(GO:0016576)
0.0	0.0	GO:0048742	regulation of skeletal muscle fiber development(GO:0048742) histone H3 deacetylation(GO:0070932) histone H4 deacetylation(GO:0070933)
0.0	0.0	GO:0021798	forebrain dorsal/ventral pattern formation(GO:0021798)
0.0	0.1	GO:1901798	positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517) positive regulation of signal transduction by p53 class mediator(GO:1901798)
0.0	0.1	GO:0043984	histone H4-K16 acetylation(GO:0043984)
0.0	0.1	GO:0031936	negative regulation of chromatin silencing(GO:0031936)
0.0	0.1	GO:0034629	cellular protein complex localization(GO:0034629)
0.0	0.1	GO:0000089	mitotic metaphase(GO:0000089)
0.0	0.1	GO:0022614	membrane to membrane docking(GO:0022614)
0.0	0.0	GO:0046101	hypoxanthine biosynthetic process(GO:0046101)
0.0	0.1	GO:0007144	female meiosis I(GO:0007144)
0.0	0.2	GO:0045070	positive regulation of viral genome replication(GO:0045070)
0.0	0.0	GO:0034392	negative regulation of smooth muscle cell apoptotic process(GO:0034392)
0.0	0.3	GO:0061077	chaperone-mediated protein folding(GO:0061077)
0.0	0.2	GO:0043576	regulation of respiratory gaseous exchange(GO:0043576)
0.0	0.1	GO:0007256	activation of JNKK activity(GO:0007256)
0.0	0.0	GO:0030011	maintenance of cell polarity(GO:0030011)
0.0	0.1	GO:0032075	positive regulation of nuclease activity(GO:0032075)
0.0	0.1	GO:0009313	oligosaccharide catabolic process(GO:0009313)
0.0	0.1	GO:0071731	response to nitric oxide(GO:0071731)
0.0	0.0	GO:0072033	renal vesicle formation(GO:0072033)
0.0	0.0	GO:0010748	negative regulation of plasma membrane long-chain fatty acid transport(GO:0010748) negative regulation of anion transmembrane transport(GO:1903960) negative regulation of fatty acid transport(GO:2000192)
0.0	0.1	GO:0007023	post-chaperonin tubulin folding pathway(GO:0007023)
0.0	0.1	GO:0045792	negative regulation of cell size(GO:0045792)
0.0	0.1	GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
0.0	0.0	GO:0060972	left/right pattern formation(GO:0060972)
0.0	0.1	GO:0002713	negative regulation of B cell mediated immunity(GO:0002713) negative regulation of immunoglobulin mediated immune response(GO:0002890)
0.0	0.1	GO:0001831	trophectodermal cellular morphogenesis(GO:0001831)
0.0	0.0	GO:0002068	glandular epithelial cell development(GO:0002068)
0.0	0.1	GO:0010956	negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137)
0.0	0.0	GO:0045591	positive regulation of regulatory T cell differentiation(GO:0045591)
0.0	0.0	GO:0044415	evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.0	0.1	GO:0032986	nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.0	0.0	GO:0045988	negative regulation of striated muscle contraction(GO:0045988)
0.0	0.1	GO:0031340	positive regulation of vesicle fusion(GO:0031340)
0.0	0.2	GO:0045880	positive regulation of smoothened signaling pathway(GO:0045880)
0.0	0.1	GO:0045663	positive regulation of myoblast differentiation(GO:0045663)
0.0	0.0	GO:0032070	regulation of deoxyribonuclease activity(GO:0032070) regulation of endodeoxyribonuclease activity(GO:0032071)
0.0	0.1	GO:0010002	cardioblast differentiation(GO:0010002)
0.0	0.0	GO:0032353	negative regulation of hormone metabolic process(GO:0032351) negative regulation of hormone biosynthetic process(GO:0032353)
0.0	0.1	GO:0043569	negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.0	0.1	GO:0016999	antibiotic metabolic process(GO:0016999) antibiotic biosynthetic process(GO:0017000)
0.0	0.0	GO:0009299	mRNA transcription(GO:0009299)
0.0	0.0	GO:0090162	establishment of epithelial cell polarity(GO:0090162)
0.0	0.1	GO:0046049	UMP biosynthetic process(GO:0006222) pyrimidine ribonucleoside monophosphate metabolic process(GO:0009173) pyrimidine ribonucleoside monophosphate biosynthetic process(GO:0009174) UMP metabolic process(GO:0046049)
0.0	0.2	GO:0045648	positive regulation of erythrocyte differentiation(GO:0045648)
0.0	0.1	GO:0048539	bone marrow development(GO:0048539)
0.0	0.0	GO:1902101	positive regulation of mitotic metaphase/anaphase transition(GO:0045842) positive regulation of mitotic sister chromatid separation(GO:1901970) positive regulation of metaphase/anaphase transition of cell cycle(GO:1902101)
0.0	0.1	GO:0046655	folic acid metabolic process(GO:0046655)
0.0	0.1	GO:0042339	keratan sulfate metabolic process(GO:0042339)
0.0	0.0	GO:0046607	positive regulation of centrosome cycle(GO:0046607)
0.0	0.0	GO:0021801	cerebral cortex radial glia guided migration(GO:0021801) telencephalon glial cell migration(GO:0022030)
0.0	0.0	GO:0000491	small nucleolar ribonucleoprotein complex assembly(GO:0000491) box C/D snoRNP assembly(GO:0000492)
0.0	0.0	GO:0033148	positive regulation of intracellular estrogen receptor signaling pathway(GO:0033148)
0.0	0.1	GO:0050916	sensory perception of sweet taste(GO:0050916)
0.0	0.0	GO:0060762	regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
0.0	0.0	GO:2000095	regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000095)
0.0	0.0	GO:0032020	ISG15-protein conjugation(GO:0032020)
0.0	0.0	GO:0060236	regulation of mitotic spindle organization(GO:0060236)
0.0	0.0	GO:2000114	regulation of establishment of cell polarity(GO:2000114)
0.0	0.0	GO:0032060	bleb assembly(GO:0032060)
0.0	0.1	GO:1904031	positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737) positive regulation of cyclin-dependent protein kinase activity(GO:1904031)
0.0	0.1	GO:0044314	protein K27-linked ubiquitination(GO:0044314)
0.0	0.1	GO:0010819	T cell chemotaxis(GO:0010818) regulation of T cell chemotaxis(GO:0010819) positive regulation of T cell chemotaxis(GO:0010820) regulation of lymphocyte chemotaxis(GO:1901623) regulation of lymphocyte migration(GO:2000401) positive regulation of lymphocyte migration(GO:2000403) regulation of T cell migration(GO:2000404) positive regulation of T cell migration(GO:2000406)
0.0	0.0	GO:0010715	regulation of extracellular matrix disassembly(GO:0010715) negative regulation of extracellular matrix disassembly(GO:0010716) regulation of extracellular matrix organization(GO:1903053) negative regulation of extracellular matrix organization(GO:1903054)
0.0	0.0	GO:0046520	sphingoid biosynthetic process(GO:0046520)
0.0	0.1	GO:1901797	negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518) negative regulation of signal transduction by p53 class mediator(GO:1901797)
0.0	0.1	GO:0031293	membrane protein intracellular domain proteolysis(GO:0031293)
0.0	0.0	GO:0035405	histone-threonine phosphorylation(GO:0035405)
0.0	0.0	GO:0006642	triglyceride mobilization(GO:0006642)
0.0	0.1	GO:0006564	L-serine biosynthetic process(GO:0006564)
0.0	0.0	GO:0060287	epithelial cilium movement(GO:0003351) epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
0.0	0.1	GO:0014721	voluntary skeletal muscle contraction(GO:0003010) twitch skeletal muscle contraction(GO:0014721)
0.0	0.0	GO:0018076	N-terminal peptidyl-lysine acetylation(GO:0018076)
0.0	0.0	GO:0060686	negative regulation of prostatic bud formation(GO:0060686)
0.0	0.0	GO:0060057	apoptotic process involved in mammary gland involution(GO:0060057) positive regulation of apoptotic process involved in mammary gland involution(GO:0060058) regulation of apoptotic process involved in morphogenesis(GO:1902337) positive regulation of apoptotic process involved in morphogenesis(GO:1902339) regulation of mammary gland involution(GO:1903519) positive regulation of mammary gland involution(GO:1903521) positive regulation of apoptotic process involved in development(GO:1904747) regulation of apoptotic process involved in development(GO:1904748)
0.0	0.0	GO:0045836	positive regulation of meiotic nuclear division(GO:0045836) positive regulation of meiotic cell cycle(GO:0051446)
0.0	0.1	GO:0048013	ephrin receptor signaling pathway(GO:0048013)
0.0	0.0	GO:0071391	cellular response to estrogen stimulus(GO:0071391)
0.0	0.1	GO:0000132	establishment of mitotic spindle orientation(GO:0000132) establishment of spindle orientation(GO:0051294)
0.0	0.0	GO:0072112	renal filtration cell differentiation(GO:0061318) glomerular epithelium development(GO:0072010) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.0	0.0	GO:0002385	innate immune response in mucosa(GO:0002227) mucosal immune response(GO:0002385)
0.0	0.1	GO:0000301	retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.0	0.1	GO:0071265	amino acid salvage(GO:0043102) L-methionine biosynthetic process(GO:0071265) L-methionine salvage(GO:0071267)
0.0	0.1	GO:0045671	negative regulation of osteoclast differentiation(GO:0045671)
0.0	0.1	GO:0014010	Schwann cell proliferation(GO:0014010)
0.0	0.3	GO:0000018	regulation of DNA recombination(GO:0000018)
0.0	0.1	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity(GO:0045197)
0.0	0.0	GO:0021555	midbrain-hindbrain boundary morphogenesis(GO:0021555)
0.0	0.3	GO:0097306	cellular response to alcohol(GO:0097306)
0.0	0.0	GO:0060743	epithelial cell maturation involved in prostate gland development(GO:0060743)
0.0	0.1	GO:0006855	drug transmembrane transport(GO:0006855)
0.0	0.1	GO:0048808	male genitalia morphogenesis(GO:0048808) male anatomical structure morphogenesis(GO:0090598)
0.0	0.1	GO:0033631	cell-cell adhesion mediated by integrin(GO:0033631)
0.0	0.1	GO:0006686	sphingomyelin biosynthetic process(GO:0006686)
0.0	0.0	GO:0007221	positive regulation of transcription of Notch receptor target(GO:0007221)
0.0	0.1	GO:0042640	anagen(GO:0042640)
0.0	0.0	GO:0071379	cellular response to prostaglandin stimulus(GO:0071379)
0.0	0.0	GO:0046599	regulation of centriole replication(GO:0046599)
0.0	0.0	GO:0009786	regulation of asymmetric cell division(GO:0009786)
0.0	0.1	GO:0006002	fructose 6-phosphate metabolic process(GO:0006002)
0.0	0.0	GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) 4-hydroxyproline metabolic process(GO:0019471) peptidyl-proline hydroxylation(GO:0019511)
0.0	0.0	GO:0051045	negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
0.0	0.0	GO:0009128	purine nucleoside monophosphate catabolic process(GO:0009128) ribonucleoside monophosphate catabolic process(GO:0009158) purine ribonucleoside monophosphate catabolic process(GO:0009169)
0.0	0.1	GO:0009649	entrainment of circadian clock(GO:0009649)
0.0	0.0	GO:0021542	dentate gyrus development(GO:0021542)
0.0	0.1	GO:0010510	acetyl-CoA biosynthetic process from pyruvate(GO:0006086) regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510) regulation of acyl-CoA biosynthetic process(GO:0050812)
0.0	0.0	GO:0007412	axon target recognition(GO:0007412)
0.0	0.0	GO:0016080	synaptic vesicle targeting(GO:0016080)
0.0	0.1	GO:0032057	negative regulation of translational initiation in response to stress(GO:0032057)
0.0	0.0	GO:0051532	NFAT protein import into nucleus(GO:0051531) regulation of NFAT protein import into nucleus(GO:0051532)
0.0	0.1	GO:0016255	attachment of GPI anchor to protein(GO:0016255)
0.0	0.1	GO:0001881	receptor recycling(GO:0001881)
0.0	0.0	GO:0051176	positive regulation of sulfur metabolic process(GO:0051176)
0.0	0.2	GO:0000380	alternative mRNA splicing, via spliceosome(GO:0000380)
0.0	0.0	GO:0045046	protein import into peroxisome membrane(GO:0045046)
0.0	0.0	GO:0060426	lung vasculature development(GO:0060426)
0.0	0.1	GO:0006607	NLS-bearing protein import into nucleus(GO:0006607)
0.0	0.2	GO:0007062	sister chromatid cohesion(GO:0007062)
0.0	0.1	GO:0032527	protein exit from endoplasmic reticulum(GO:0032527)
0.0	0.0	GO:0034720	histone H3-K4 demethylation(GO:0034720)
0.0	0.0	GO:0032455	nerve growth factor processing(GO:0032455)
0.0	0.0	GO:0045627	positive regulation of T-helper 1 cell differentiation(GO:0045627)
0.0	0.0	GO:0060528	secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.0	0.0	GO:0045601	regulation of endothelial cell differentiation(GO:0045601)
0.0	0.1	GO:0034446	substrate adhesion-dependent cell spreading(GO:0034446)
0.0	0.0	GO:0035520	monoubiquitinated protein deubiquitination(GO:0035520)
0.0	0.0	GO:0008298	intracellular mRNA localization(GO:0008298)
0.0	0.0	GO:0072385	minus-end-directed organelle transport along microtubule(GO:0072385)
0.0	0.0	GO:0070050	neuron cellular homeostasis(GO:0070050)
0.0	0.0	GO:0042726	flavin-containing compound metabolic process(GO:0042726)
0.0	0.0	GO:0040016	embryonic cleavage(GO:0040016)
0.0	0.2	GO:0042130	negative regulation of T cell proliferation(GO:0042130)
0.0	0.1	GO:0042797	5S class rRNA transcription from RNA polymerase III type 1 promoter(GO:0042791) tRNA transcription from RNA polymerase III promoter(GO:0042797)
0.0	0.0	GO:0006556	S-adenosylmethionine biosynthetic process(GO:0006556)
0.0	0.2	GO:0030520	intracellular estrogen receptor signaling pathway(GO:0030520)
0.0	0.1	GO:0016127	cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.0	0.0	GO:0051552	flavone metabolic process(GO:0051552)
0.0	0.0	GO:0060049	regulation of protein glycosylation(GO:0060049)
0.0	0.0	GO:0060061	Spemann organizer formation(GO:0060061)
0.0	0.0	GO:0035455	response to interferon-alpha(GO:0035455)
0.0	0.0	GO:0031117	positive regulation of microtubule depolymerization(GO:0031117)
0.0	0.1	GO:0070934	CRD-mediated mRNA stabilization(GO:0070934)
0.0	0.0	GO:0001705	ectoderm formation(GO:0001705)
0.0	0.3	GO:0032480	negative regulation of type I interferon production(GO:0032480)
0.0	0.0	GO:0043490	malate-aspartate shuttle(GO:0043490)
0.0	0.1	GO:0043267	negative regulation of potassium ion transport(GO:0043267)
0.0	0.0	GO:0010832	negative regulation of myotube differentiation(GO:0010832) negative regulation of striated muscle cell differentiation(GO:0051154)
0.0	0.1	GO:0010833	telomere maintenance via telomere lengthening(GO:0010833)
0.0	0.0	GO:0032205	negative regulation of telomere maintenance(GO:0032205)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0070022	transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.1	0.1	GO:0031235	intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0	0.1	GO:0031932	TORC2 complex(GO:0031932)
0.0	0.2	GO:0036454	insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454)
0.0	0.2	GO:0071437	invadopodium(GO:0071437)
0.0	0.1	GO:0005945	6-phosphofructokinase complex(GO:0005945)
0.0	0.1	GO:0044453	integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.0	0.1	GO:0048179	activin receptor complex(GO:0048179)
0.0	0.2	GO:0099738	cell cortex region(GO:0099738)
0.0	0.1	GO:0034045	pre-autophagosomal structure membrane(GO:0034045)
0.0	0.3	GO:0071564	npBAF complex(GO:0071564)
0.0	0.1	GO:0031616	spindle pole centrosome(GO:0031616)
0.0	0.1	GO:0072487	MSL complex(GO:0072487)
0.0	0.1	GO:0000506	glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0	0.1	GO:0005869	dynactin complex(GO:0005869)
0.0	0.1	GO:0032059	bleb(GO:0032059)
0.0	0.1	GO:0032588	trans-Golgi network membrane(GO:0032588)
0.0	0.1	GO:0043240	Fanconi anaemia nuclear complex(GO:0043240)
0.0	0.2	GO:0008091	spectrin(GO:0008091)
0.0	0.1	GO:0001931	uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0	0.1	GO:0030056	hemidesmosome(GO:0030056)
0.0	0.1	GO:0042272	nuclear RNA export factor complex(GO:0042272)
0.0	0.2	GO:0017119	Golgi transport complex(GO:0017119)
0.0	0.1	GO:0000124	SAGA complex(GO:0000124)
0.0	0.1	GO:0035189	Rb-E2F complex(GO:0035189)
0.0	0.1	GO:0042765	GPI-anchor transamidase complex(GO:0042765)
0.0	0.0	GO:0014731	spectrin-associated cytoskeleton(GO:0014731)
0.0	0.0	GO:0070188	obsolete Stn1-Ten1 complex(GO:0070188)
0.0	0.1	GO:0045275	mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.0	0.0	GO:0045254	pyruvate dehydrogenase complex(GO:0045254)
0.0	0.1	GO:0005672	transcription factor TFIIA complex(GO:0005672)
0.0	0.2	GO:0000780	condensed nuclear chromosome, centromeric region(GO:0000780)
0.0	0.1	GO:0005577	fibrinogen complex(GO:0005577)
0.0	0.2	GO:0010494	cytoplasmic stress granule(GO:0010494)
0.0	0.1	GO:0002102	podosome(GO:0002102)
0.0	0.1	GO:0005828	kinetochore microtubule(GO:0005828)
0.0	0.1	GO:0043190	ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.0	0.3	GO:0046658	anchored component of plasma membrane(GO:0046658)
0.0	0.1	GO:0001741	XY body(GO:0001741)
0.0	0.0	GO:0071664	catenin-TCF7L2 complex(GO:0071664)
0.0	0.1	GO:0032156	septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.0	0.0	GO:0031618	nuclear pericentric heterochromatin(GO:0031618)
0.0	0.1	GO:0001891	phagocytic cup(GO:0001891)
0.0	0.0	GO:0043259	laminin-10 complex(GO:0043259)
0.0	0.1	GO:0005742	mitochondrial outer membrane translocase complex(GO:0005742)
0.0	0.0	GO:0000164	protein phosphatase type 1 complex(GO:0000164)
0.0	0.1	GO:0005658	alpha DNA polymerase:primase complex(GO:0005658)
0.0	0.1	GO:0005797	Golgi medial cisterna(GO:0005797)
0.0	0.1	GO:0030992	intraciliary transport particle B(GO:0030992)
0.0	0.3	GO:0005637	nuclear inner membrane(GO:0005637)
0.0	0.0	GO:0033270	paranode region of axon(GO:0033270)
0.0	0.1	GO:0000127	transcription factor TFIIIC complex(GO:0000127)
0.0	0.4	GO:0032587	ruffle membrane(GO:0032587)
0.0	0.1	GO:0030128	AP-2 adaptor complex(GO:0030122) clathrin coat of endocytic vesicle(GO:0030128)
0.0	0.3	GO:0030175	filopodium(GO:0030175)
0.0	0.1	GO:0042599	lamellar body(GO:0042599)
0.0	0.0	GO:0005686	U2 snRNP(GO:0005686)
0.0	0.1	GO:0005890	sodium:potassium-exchanging ATPase complex(GO:0005890)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0005025	transforming growth factor beta receptor activity, type I(GO:0005025)
0.0	0.2	GO:0004706	JUN kinase kinase kinase activity(GO:0004706)
0.0	0.1	GO:0015254	glycerol channel activity(GO:0015254)
0.0	0.1	GO:0030215	semaphorin receptor binding(GO:0030215)
0.0	0.1	GO:0000987	RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.0	0.2	GO:0000900	translation repressor activity, nucleic acid binding(GO:0000900)
0.0	0.1	GO:0042799	histone methyltransferase activity (H4-K20 specific)(GO:0042799)
0.0	0.1	GO:0008174	mRNA methyltransferase activity(GO:0008174)
0.0	0.2	GO:0050431	transforming growth factor beta binding(GO:0050431)
0.0	0.1	GO:0031995	insulin-like growth factor II binding(GO:0031995)
0.0	0.3	GO:0003785	actin monomer binding(GO:0003785)
0.0	0.2	GO:0008568	microtubule-severing ATPase activity(GO:0008568)
0.0	0.2	GO:0004908	interleukin-1 receptor activity(GO:0004908)
0.0	0.1	GO:0005176	ErbB-2 class receptor binding(GO:0005176)
0.0	0.1	GO:0003872	6-phosphofructokinase activity(GO:0003872)
0.0	0.2	GO:0050811	GABA receptor binding(GO:0050811)
0.0	0.1	GO:0003726	double-stranded RNA adenosine deaminase activity(GO:0003726)
0.0	0.1	GO:0043047	single-stranded telomeric DNA binding(GO:0043047) sequence-specific single stranded DNA binding(GO:0098847)
0.0	0.1	GO:0008517	folic acid transporter activity(GO:0008517)
0.0	0.2	GO:0070087	chromo shadow domain binding(GO:0070087)
0.0	0.2	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0	0.1	GO:0055077	gap junction hemi-channel activity(GO:0055077)
0.0	0.3	GO:0004198	calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0	0.1	GO:0004311	farnesyltranstransferase activity(GO:0004311)
0.0	0.0	GO:0005006	epidermal growth factor-activated receptor activity(GO:0005006)
0.0	0.2	GO:0051879	Hsp90 protein binding(GO:0051879)
0.0	0.1	GO:0005432	calcium:sodium antiporter activity(GO:0005432)
0.0	0.1	GO:0017154	semaphorin receptor activity(GO:0017154)
0.0	0.2	GO:0047372	acylglycerol lipase activity(GO:0047372)
0.0	0.1	GO:0060230	lipoprotein lipase activator activity(GO:0060230)
0.0	0.1	GO:0043515	kinetochore binding(GO:0043515)
0.0	0.1	GO:0031702	type 1 angiotensin receptor binding(GO:0031702)
0.0	0.1	GO:0030375	thyroid hormone receptor coactivator activity(GO:0030375)
0.0	0.3	GO:0043014	alpha-tubulin binding(GO:0043014)
0.0	0.1	GO:0032794	GTPase activating protein binding(GO:0032794)
0.0	0.0	GO:0004826	phenylalanine-tRNA ligase activity(GO:0004826)
0.0	0.2	GO:0048487	beta-tubulin binding(GO:0048487)
0.0	0.1	GO:0004427	inorganic diphosphatase activity(GO:0004427)
0.0	0.1	GO:0005250	A-type (transient outward) potassium channel activity(GO:0005250)
0.0	0.2	GO:0004016	adenylate cyclase activity(GO:0004016)
0.0	0.1	GO:0004465	lipoprotein lipase activity(GO:0004465)
0.0	0.1	GO:0003923	GPI-anchor transamidase activity(GO:0003923)
0.0	0.1	GO:0001537	N-acetylgalactosamine 4-O-sulfotransferase activity(GO:0001537)
0.0	0.1	GO:0008266	poly(U) RNA binding(GO:0008266)
0.0	0.0	GO:0043533	inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.0	0.1	GO:0008432	JUN kinase binding(GO:0008432)
0.0	0.4	GO:0000049	tRNA binding(GO:0000049)
0.0	0.1	GO:0005078	MAP-kinase scaffold activity(GO:0005078)
0.0	0.1	GO:0043140	ATP-dependent 3'-5' DNA helicase activity(GO:0043140)
0.0	0.3	GO:0008601	protein phosphatase type 2A regulator activity(GO:0008601)
0.0	0.1	GO:0015288	porin activity(GO:0015288)
0.0	0.1	GO:0004691	cAMP-dependent protein kinase activity(GO:0004691)
0.0	0.1	GO:0005131	growth hormone receptor binding(GO:0005131)
0.0	0.0	GO:0035184	histone threonine kinase activity(GO:0035184)
0.0	0.2	GO:0050750	low-density lipoprotein particle receptor binding(GO:0050750)
0.0	0.0	GO:0004517	nitric-oxide synthase activity(GO:0004517)
0.0	0.0	GO:0019834	phospholipase A2 inhibitor activity(GO:0019834)
0.0	0.1	GO:0030332	cyclin binding(GO:0030332)
0.0	0.1	GO:0031013	troponin I binding(GO:0031013)
0.0	0.0	GO:0016004	phospholipase activator activity(GO:0016004)
0.0	0.0	GO:0019166	trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166)
0.0	0.1	GO:0004528	phosphodiesterase I activity(GO:0004528)
0.0	0.4	GO:0017137	Rab GTPase binding(GO:0017137)
0.0	0.0	GO:0004758	serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0	0.1	GO:0015165	pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.0	0.0	GO:0032554	purine deoxyribonucleotide binding(GO:0032554) adenyl deoxyribonucleotide binding(GO:0032558)
0.0	0.2	GO:0003995	acyl-CoA dehydrogenase activity(GO:0003995)
0.0	0.1	GO:0051864	histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0	0.1	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0	0.1	GO:0016635	oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor(GO:0016635)
0.0	0.3	GO:0008093	cytoskeletal adaptor activity(GO:0008093)
0.0	0.0	GO:0008934	inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate phosphatase activity(GO:0052834)
0.0	0.1	GO:0016417	S-acyltransferase activity(GO:0016417)
0.0	0.1	GO:0034593	phosphatidylinositol bisphosphate phosphatase activity(GO:0034593)
0.0	0.0	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.0	0.0	GO:0005047	signal recognition particle binding(GO:0005047)
0.0	0.0	GO:0050510	N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510)
0.0	0.1	GO:0016944	obsolete RNA polymerase II transcription elongation factor activity(GO:0016944)
0.0	0.0	GO:0004476	mannose-6-phosphate isomerase activity(GO:0004476)
0.0	0.0	GO:0050693	LBD domain binding(GO:0050693)
0.0	0.0	GO:0045502	dynein binding(GO:0045502)
0.0	0.0	GO:0043398	HLH domain binding(GO:0043398)
0.0	0.0	GO:0008332	low voltage-gated calcium channel activity(GO:0008332)
0.0	0.0	GO:0032453	histone demethylase activity (H3-K4 specific)(GO:0032453) histone demethylase activity (H3-dimethyl-K4 specific)(GO:0034648)
0.0	0.1	GO:0032405	MutLalpha complex binding(GO:0032405)
0.0	0.0	GO:0042808	obsolete neuronal Cdc2-like kinase binding(GO:0042808)
0.0	0.1	GO:0015279	store-operated calcium channel activity(GO:0015279)
0.0	0.1	GO:0016308	1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.0	0.1	GO:0017025	TBP-class protein binding(GO:0017025)
0.0	0.2	GO:0008484	sulfuric ester hydrolase activity(GO:0008484)
0.0	0.1	GO:0016409	palmitoyltransferase activity(GO:0016409)
0.0	0.1	GO:0016273	arginine N-methyltransferase activity(GO:0016273) protein-arginine N-methyltransferase activity(GO:0016274)
0.0	0.1	GO:0004673	protein histidine kinase activity(GO:0004673)
0.0	0.1	GO:0000832	inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832)
0.0	0.1	GO:0050656	3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
0.0	0.1	GO:0008318	protein prenyltransferase activity(GO:0008318)
0.0	0.0	GO:0050508	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.0	0.0	GO:0045545	syndecan binding(GO:0045545)
0.0	0.1	GO:0008271	secondary active sulfate transmembrane transporter activity(GO:0008271)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.1	PID TRAIL PATHWAY	TRAIL signaling pathway
0.5	PID ALK1 PATHWAY	ALK1 signaling events
0.0	PID P38 ALPHA BETA PATHWAY	Regulation of p38-alpha and p38-beta
0.6	PID SYNDECAN 4 PATHWAY	Syndecan-4-mediated signaling events
0.2	PID ERB GENOMIC PATHWAY	Validated nuclear estrogen receptor beta network
0.6	PID RHOA PATHWAY	RhoA signaling pathway
0.2	PID CIRCADIAN PATHWAY	Circadian rhythm pathway
0.1	PID ECADHERIN KERATINOCYTE PATHWAY	E-cadherin signaling in keratinocytes
0.1	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
0.6	PID FOXO PATHWAY	FoxO family signaling
0.0	SA TRKA RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.2	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.2	PID NCADHERIN PATHWAY	N-cadherin signaling events
0.7	PID BETA CATENIN NUC PATHWAY	Regulation of nuclear beta catenin signaling and target gene transcription
0.0	PID IL5 PATHWAY	IL5-mediated signaling events
0.2	PID AVB3 OPN PATHWAY	Osteopontin-mediated events
0.2	PID ERBB4 PATHWAY	ErbB4 signaling events
0.4	PID HES HEY PATHWAY	Notch-mediated HES/HEY network
0.1	PID EPHA2 FWD PATHWAY	EPHA2 forward signaling
0.1	SIG CHEMOTAXIS	Genes related to chemotaxis
0.1	PID S1P S1P4 PATHWAY	S1P4 pathway
0.1	PID NFKAPPAB CANONICAL PATHWAY	Canonical NF-kappaB pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.1	REACTOME DESTABILIZATION OF MRNA BY KSRP	Genes involved in Destabilization of mRNA by KSRP
0.0	0.1	REACTOME G ALPHA1213 SIGNALLING EVENTS	Genes involved in G alpha (12/13) signalling events
0.0	0.0	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0	0.4	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.0	0.4	REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0	0.1	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.0	0.1	REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY	Genes involved in Regulation of the Fanconi anemia pathway
0.0	0.0	REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI	Genes involved in RIP-mediated NFkB activation via DAI
0.0	0.2	REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0	0.2	REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY	Genes involved in Adenylate cyclase activating pathway
0.0	0.4	REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA	Genes involved in Circadian Repression of Expression by REV-ERBA
0.0	0.1	REACTOME DESTABILIZATION OF MRNA BY BRF1	Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.0	0.2	REACTOME OTHER SEMAPHORIN INTERACTIONS	Genes involved in Other semaphorin interactions
0.0	0.3	REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION	Genes involved in Pre-NOTCH Transcription and Translation
0.0	0.3	REACTOME CD28 DEPENDENT PI3K AKT SIGNALING	Genes involved in CD28 dependent PI3K/Akt signaling
0.0	0.4	REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0	0.2	REACTOME PD1 SIGNALING	Genes involved in PD-1 signaling
0.0	0.1	REACTOME PASSIVE TRANSPORT BY AQUAPORINS	Genes involved in Passive Transport by Aquaporins
0.0	0.0	REACTOME PECAM1 INTERACTIONS	Genes involved in PECAM1 interactions
0.0	0.0	REACTOME AQUAPORIN MEDIATED TRANSPORT	Genes involved in Aquaporin-mediated transport
0.0	0.0	REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING	Genes involved in Role of second messengers in netrin-1 signaling
0.0	0.0	REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1	Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.0	0.2	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0	0.1	REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0	0.2	REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Glutamate Neurotransmitter Release Cycle
0.0	0.3	REACTOME G1 PHASE	Genes involved in G1 Phase
0.0	0.3	REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING	Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0	0.2	REACTOME G1 S SPECIFIC TRANSCRIPTION	Genes involved in G1/S-Specific Transcription
0.0	0.1	REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS	Genes involved in Elevation of cytosolic Ca2+ levels
0.0	0.1	REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS	Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0	0.1	REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION	Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0	0.1	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.0	0.2	REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY	Genes involved in Post-chaperonin tubulin folding pathway
0.0	0.0	REACTOME P75NTR SIGNALS VIA NFKB	Genes involved in p75NTR signals via NF-kB
0.0	0.3	REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS	Genes involved in Sphingolipid de novo biosynthesis