CREMA results: MSX2

Motif logo

Transcription factors associated with MSX2

Gene Symbol	Gene ID	Gene Info
MSX2 Ensembl NCBI GeneCards UniProt	ENSG00000120149.7	msh homeobox 2

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Search:

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
chr5_173882231_173882382	MSX2	269230	0.015351	0.67	4.6e-02	Click!
chr5_173888101_173888252	MSX2	263360	0.016023	0.67	4.6e-02	Click!
chr5_173916383_173916534	MSX2	235078	0.019896	-0.69	3.8e-02	Click!
chr5_173918124_173918275	MSX2	233337	0.020178	-0.69	4.1e-02	Click!
chr5_174151057_174151248	MSX2	384	0.906182	0.81	8.5e-03	Click!

Showing 1 to 5 of 5 entries

Activity of the MSX2 motif across conditions

Conditions sorted by the z-value of the MSX2 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Search:

Show entries

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr17_64419641_64419918	0.70	RP11-4F22.2		6807	0.26
chr18_59619334_59619485	0.65	RNF152	ring finger protein 152	57945	0.16
chr3_17274716_17274867	0.60	ENSG00000252976	.	97577	0.08
chr2_235231609_235231760	0.56	ARL4C	ADP-ribosylation factor-like 4C	173560	0.03
chr7_150635354_150635936	0.53	KCNH2	potassium voltage-gated channel, subfamily H (eag-related), member 2	17349	0.15
chr14_99720519_99720759	0.47	AL109767.1		8646	0.22
chr10_98301601_98301752	0.47	TLL2	tolloid-like 2	28008	0.18
chr22_19463070_19463221	0.44	UFD1L	ubiquitin fusion degradation 1 like (yeast)	3309	0.13
chr12_112779348_112779499	0.44	HECTD4	HECT domain containing E3 ubiquitin protein ligase 4	40473	0.14
chr11_20135030_20135181	0.42	NAV2-AS1	NAV2 antisense RNA 1	7073	0.24

Showing 1 to 10 of 200 entries

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of MSX2

View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.3	GO:0060037	pharyngeal system development(GO:0060037)
0.0	0.3	GO:0021527	spinal cord association neuron differentiation(GO:0021527)
0.0	0.3	GO:0061077	chaperone-mediated protein folding(GO:0061077)
0.0	0.3	GO:0000018	regulation of DNA recombination(GO:0000018)
0.0	0.3	GO:0097306	cellular response to alcohol(GO:0097306)
0.0	0.3	GO:0032480	negative regulation of type I interferon production(GO:0032480)
0.1	0.2	GO:0051138	NK T cell differentiation(GO:0001865) regulation of NK T cell differentiation(GO:0051136) positive regulation of NK T cell differentiation(GO:0051138)
0.1	0.2	GO:0010761	fibroblast migration(GO:0010761)
0.1	0.2	GO:0070266	necroptotic process(GO:0070266) programmed necrotic cell death(GO:0097300)
0.1	0.2	GO:0045875	negative regulation of sister chromatid cohesion(GO:0045875)

Showing 1 to 10 of 194 entries

Gene overrepresentation in cellular component category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.4	GO:0032587	ruffle membrane(GO:0032587)
0.1	0.3	GO:0070022	transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0	0.3	GO:0071564	npBAF complex(GO:0071564)
0.0	0.3	GO:0046658	anchored component of plasma membrane(GO:0046658)
0.0	0.3	GO:0005637	nuclear inner membrane(GO:0005637)
0.0	0.3	GO:0030175	filopodium(GO:0030175)
0.0	0.2	GO:0036454	insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454)
0.0	0.2	GO:0071437	invadopodium(GO:0071437)
0.0	0.2	GO:0099738	cell cortex region(GO:0099738)
0.0	0.2	GO:0008091	spectrin(GO:0008091)

Showing 1 to 10 of 58 entries

Gene overrepresentation in molecular function category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.4	GO:0000049	tRNA binding(GO:0000049)
0.0	0.4	GO:0017137	Rab GTPase binding(GO:0017137)
0.0	0.3	GO:0003785	actin monomer binding(GO:0003785)
0.0	0.3	GO:0004198	calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0	0.3	GO:0043014	alpha-tubulin binding(GO:0043014)
0.0	0.3	GO:0008601	protein phosphatase type 2A regulator activity(GO:0008601)
0.0	0.3	GO:0008093	cytoskeletal adaptor activity(GO:0008093)
0.1	0.2	GO:0005025	transforming growth factor beta receptor activity, type I(GO:0005025)
0.0	0.2	GO:0004706	JUN kinase kinase kinase activity(GO:0004706)
0.0	0.2	GO:0000900	translation repressor activity, nucleic acid binding(GO:0000900)

Showing 1 to 10 of 99 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

Search:

Show entries

Total log-likelihood	Term	Description
0.7	PID BETA CATENIN NUC PATHWAY	Regulation of nuclear beta catenin signaling and target gene transcription
0.6	PID SYNDECAN 4 PATHWAY	Syndecan-4-mediated signaling events
0.6	PID RHOA PATHWAY	RhoA signaling pathway
0.6	PID FOXO PATHWAY	FoxO family signaling
0.5	PID ALK1 PATHWAY	ALK1 signaling events
0.4	PID HES HEY PATHWAY	Notch-mediated HES/HEY network
0.2	PID ERB GENOMIC PATHWAY	Validated nuclear estrogen receptor beta network
0.2	PID CIRCADIAN PATHWAY	Circadian rhythm pathway
0.2	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.2	PID NCADHERIN PATHWAY	N-cadherin signaling events

Showing 1 to 10 of 22 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Search:

Show entries

Total log-likelihood	Term	Description
0.4	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.4	REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.4	REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA	Genes involved in Circadian Repression of Expression by REV-ERBA
0.4	REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.3	REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION	Genes involved in Pre-NOTCH Transcription and Translation
0.3	REACTOME CD28 DEPENDENT PI3K AKT SIGNALING	Genes involved in CD28 dependent PI3K/Akt signaling
0.3	REACTOME G1 PHASE	Genes involved in G1 Phase
0.3	REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING	Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.3	REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS	Genes involved in Sphingolipid de novo biosynthesis
0.2	REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression

Showing 1 to 10 of 35 entries

Results for MSX2

Z-value: 1.03

Motif logo

Transcription factors associated with MSX2

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Activity of the MSX2 motif across conditions

Conditions sorted by the z-value of the MSX2 motif activity

Top target CREs of the motif:

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of MSX2

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: