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ENCODE: H3K4me1 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for NANOG

Z-value: 1.03

Motif logo

Transcription factors associated with NANOG

Gene Symbol	Gene ID	Gene Info
NANOG Ensembl NCBI GeneCards UniProt	ENSG00000111704.6	NANOG

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
NANOG	chr12_7945278_7945429	3142	0.146781	0.13	7.3e-01	Click!
NANOG	chr12_7945753_7945904	3617	0.136931	0.01	9.9e-01	Click!
NANOG	chr12_7946157_7946308	4021	0.130954	-0.01	9.9e-01	Click!

Activity of the NANOG motif across conditions

Conditions sorted by the z-value of the NANOG motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr12_20557654_20557988	0.34	RP11-284H19.1		34625	0.2
chr1_205670529_205670680	0.32	AC119673.1		11893	0.14
chr3_49748675_49748961	0.30	RNF123	ring finger protein 123	1445	0.27
chr3_149160811_149161262	0.30	TM4SF4	transmembrane 4 L six family member 4	30725	0.16
chr16_49565236_49565387	0.29	ZNF423	zinc finger protein 423	109452	0.07
chr11_32447864_32448015	0.28	WT1	Wilms tumor 1	2636	0.33
chr3_121774222_121774373	0.27	CD86	CD86 molecule	76	0.97
chr15_33299614_33299765	0.26	ENSG00000212415	.	36761	0.19
chr1_25335272_25335426	0.26	ENSG00000264371	.	14645	0.2
chr4_57909352_57909761	0.25	ENSG00000251703	.	40698	0.11
chr8_96705142_96705479	0.25	ENSG00000223297	.	14167	0.29
chr11_72985767_72986011	0.25	P2RY6	pyrimidinergic receptor P2Y, G-protein coupled, 6	2424	0.23
chr2_62356561_62356823	0.24	COMMD1	copper metabolism (Murr1) domain containing 1	6288	0.21
chr12_113308184_113308335	0.24	OAS1	2'-5'-oligoadenylate synthetase 1, 40/46kDa	36323	0.15
chr1_26354858_26355009	0.24	EXTL1	exostosin-like glycosyltransferase 1	6662	0.1
chr2_202083500_202083651	0.24	CASP8	caspase 8, apoptosis-related cysteine peptidase	14591	0.16
chr2_206648577_206648850	0.23	AC007362.3		19983	0.24
chr8_104165322_104165473	0.23	ENSG00000265657	.	1445	0.3
chr2_105594341_105594492	0.23	ENSG00000263685	.	15022	0.19
chr17_32694389_32694669	0.22	CCL1	chemokine (C-C motif) ligand 1	4279	0.2
chr17_78723949_78724201	0.22	RP11-28G8.1		55357	0.14
chr3_37499337_37499488	0.22	ITGA9	integrin, alpha 9	5802	0.25
chr8_24206460_24207135	0.22	ADAM28	ADAM metallopeptidase domain 28	7632	0.22
chr8_6149074_6149420	0.22	RP11-115C21.2		114816	0.06
chr4_173708241_173708420	0.22	ENSG00000241652	.	354464	0.01
chr5_71768852_71769003	0.22	RP11-389C8.2		30713	0.19
chr8_125434775_125435085	0.22	TRMT12	tRNA methyltransferase 12 homolog (S. cerevisiae)	28118	0.16
chr12_6482203_6482355	0.21	SCNN1A	sodium channel, non-voltage-gated 1 alpha subunit	1690	0.23
chr14_35837591_35837748	0.21	NFKBIA	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	35677	0.17
chr6_134537452_134537663	0.21	ENSG00000238631	.	9905	0.2
chr2_231750819_231750970	0.21	AC012507.3		321	0.87
chr10_80937857_80938019	0.20	ZMIZ1	zinc finger, MIZ-type containing 1	109146	0.07
chr7_26685921_26686196	0.20	C7orf71	chromosome 7 open reading frame 71	8568	0.29
chr15_81400350_81400501	0.20	C15orf26	chromosome 15 open reading frame 26	8676	0.24
chr20_50010365_50010516	0.20	ENSG00000263645	.	16582	0.25
chr2_42304204_42304355	0.20	PKDCC	protein kinase domain containing, cytoplasmic	29119	0.18
chr9_129151715_129152192	0.20	MVB12B	multivesicular body subunit 12B	13231	0.2
chr17_72599092_72599393	0.20	CD300LD	CD300 molecule-like family member d	10820	0.12
chr16_23907560_23907711	0.20	PRKCB	protein kinase C, beta	59091	0.13
chr12_12013798_12013949	0.20	ETV6	ets variant 6	24998	0.26
chr19_17790984_17791135	0.19	UNC13A	unc-13 homolog A (C. elegans)	4081	0.18
chr3_168931111_168931360	0.19	MECOM	MDS1 and EVI1 complex locus	55791	0.17
chr18_46580939_46581171	0.19	ENSG00000263849	.	4917	0.22
chr3_148477195_148477534	0.19	AGTR1	angiotensin II receptor, type 1	19779	0.22
chr9_95823092_95823243	0.19	SUSD3	sushi domain containing 3	2106	0.29
chr18_13268737_13268888	0.19	LDLRAD4	low density lipoprotein receptor class A domain containing 4	9290	0.2
chr14_52782524_52782774	0.19	PTGER2	prostaglandin E receptor 2 (subtype EP2), 53kDa	1536	0.5
chr16_46782782_46782933	0.19	MYLK3	myosin light chain kinase 3	636	0.74
chr2_6920801_6920998	0.19	AC017076.5		52763	0.14
chr16_81868234_81868705	0.19	PLCG2	phospholipase C, gamma 2 (phosphatidylinositol-specific)	48405	0.17
chr19_11433238_11433389	0.19	CTC-510F12.6		481	0.63
chr2_200527098_200527249	0.19	FTCDNL1	formiminotransferase cyclodeaminase N-terminal like	188423	0.03
chr1_171624147_171624306	0.18	MYOC	myocilin, trabecular meshwork inducible glucocorticoid response	2403	0.34
chr15_66938215_66938421	0.18	SMAD6	SMAD family member 6	56248	0.1
chr11_109966413_109966654	0.18	ZC3H12C	zinc finger CCCH-type containing 12C	2446	0.45
chr13_21620980_21621217	0.18	ENSG00000201821	.	8292	0.15
chr12_2723257_2723602	0.18	CACNA1C-AS3	CACNA1C antisense RNA 3	6823	0.24
chr17_72542253_72542431	0.18	CD300C	CD300c molecule	60	0.96
chr19_12800165_12800409	0.18	CTD-2659N19.2		551	0.5
chr2_145462594_145462835	0.18	ZEB2	zinc finger E-box binding homeobox 2	184093	0.03
chr22_26047284_26047507	0.18	ENSG00000222585	.	63741	0.09
chr1_153941559_153941710	0.18	CREB3L4	cAMP responsive element binding protein 3-like 4	848	0.32
chr3_42068290_42068573	0.17	TRAK1	trafficking protein, kinesin binding 1	64131	0.11
chr3_193564257_193564433	0.17	ENSG00000243991	.	105835	0.07
chr14_63672742_63672893	0.17	RHOJ	ras homolog family member J	1240	0.55
chr22_17739441_17739786	0.17	CECR1	cat eye syndrome chromosome region, candidate 1	36734	0.16
chr16_6914698_6914849	0.17	ENSG00000200869	.	9127	0.29
chr10_4927599_4927750	0.17	AKR1C1	aldo-keto reductase family 1, member C1	7122	0.22
chr22_23933547_23933698	0.17	IGLL1	immunoglobulin lambda-like polypeptide 1	11127	0.15
chr13_43919735_43919886	0.17	ENOX1	ecto-NOX disulfide-thiol exchanger 1	15403	0.31
chr15_39687457_39687608	0.17	RP11-624L4.1		25378	0.25
chr6_56194231_56194392	0.17	RP3-445N2.1		2604	0.38
chr4_109454301_109454616	0.17	ENSG00000266046	.	43838	0.17
chr5_177667409_177667628	0.17	PHYKPL	5-phosphohydroxy-L-lysine phospho-lyase	7732	0.21
chr1_117040601_117040786	0.17	ENSG00000200547	.	45535	0.11
chr14_75295916_75296067	0.17	YLPM1	YLP motif containing 1	12050	0.14
chr5_139036948_139037177	0.17	CXXC5	CXXC finger protein 5	2078	0.35
chr5_179588041_179588247	0.17	RASGEF1C	RasGEF domain family, member 1C	22795	0.21
chr4_10706517_10706811	0.17	CLNK	cytokine-dependent hematopoietic cell linker	20175	0.29
chr2_29415943_29416138	0.17	ALK	anaplastic lymphoma receptor tyrosine kinase	30220	0.18
chr3_51555997_51556148	0.17	RAD54L2	RAD54-like 2 (S. cerevisiae)	19524	0.18
chr7_142430889_142431059	0.17	PRSS1	protease, serine, 1 (trypsin 1)	26345	0.17
chr5_134718436_134718820	0.16	H2AFY	H2A histone family, member Y	16273	0.15
chr3_188139152_188139752	0.16	LPP-AS1	LPP antisense RNA 1	147002	0.04
chr3_71976245_71976396	0.16	ENSG00000239250	.	99992	0.08
chr1_205206275_205206426	0.16	RP11-383G10.5		355	0.86
chr1_213499256_213499407	0.16	RPS6KC1	ribosomal protein S6 kinase, 52kDa, polypeptide 1	274727	0.01
chr6_1850485_1850731	0.16	FOXC1	forkhead box C1	239927	0.02
chr8_17004029_17004180	0.16	ZDHHC2	zinc finger, DHHC-type containing 2	9434	0.25
chr6_169615307_169615476	0.16	XXyac-YX65C7_A.2		2042	0.43
chr6_136748361_136748512	0.16	MAP7	microtubule-associated protein 7	39577	0.18
chr19_19635191_19635342	0.16	YJEFN3	YjeF N-terminal domain containing 3	4404	0.12
chr1_109934550_109935130	0.16	SORT1	sortilin 1	1139	0.45
chr21_32641465_32641616	0.16	TIAM1	T-cell lymphoma invasion and metastasis 1	7543	0.31
chr4_88628609_88628760	0.16	RP11-742B18.1		24838	0.15
chr14_56880037_56880188	0.16	TMEM260	transmembrane protein 260	74960	0.12
chr2_218776477_218776674	0.16	TNS1	tensin 1	6391	0.26
chr4_16034919_16035070	0.16	ENSG00000251758	.	24584	0.18
chr2_122572651_122572909	0.16	TSN	translin	59033	0.13
chr3_150805055_150805642	0.16	MED12L	mediator complex subunit 12-like	667	0.76
chr17_72387513_72387690	0.16	GPR142	G protein-coupled receptor 142	24004	0.1
chr1_235055137_235055288	0.16	ENSG00000239690	.	15279	0.26
chr12_102170928_102171079	0.16	ENSG00000201168	.	2589	0.16
chr17_55082561_55082712	0.16	ENSG00000265809	.	2292	0.23
chr7_150549245_150549396	0.16	AOC1	amine oxidase, copper containing 1	223	0.93
chr16_70456809_70457112	0.16	ST3GAL2	ST3 beta-galactoside alpha-2,3-sialyltransferase 2	16031	0.11
chr15_45927791_45927942	0.16	SQRDL	sulfide quinone reductase-like (yeast)	928	0.56
chr3_18022579_18022730	0.15	TBC1D5	TBC1 domain family, member 5	238510	0.02
chr8_110032427_110032578	0.15	RP11-1084E5.1		43144	0.18
chr3_37601222_37601385	0.15	ENSG00000239105	.	13401	0.26
chr12_53026253_53026404	0.15	KRT73	keratin 73	13985	0.1
chr12_26303323_26303715	0.15	SSPN	sarcospan	15619	0.18
chr18_10354698_10354849	0.15	ENSG00000239031	.	35224	0.21
chr5_82672926_82673088	0.15	VCAN	versican	94277	0.09
chr9_92236942_92237093	0.15	GADD45G	growth arrest and DNA-damage-inducible, gamma	17064	0.27
chr1_108484035_108484186	0.15	VAV3-AS1	VAV3 antisense RNA 1	22955	0.2
chr12_48111947_48112151	0.15	ENDOU	endonuclease, polyU-specific	617	0.69
chr5_142076865_142077016	0.15	FGF1	fibroblast growth factor 1 (acidic)	646	0.77
chr6_44537708_44537867	0.15	ENSG00000266619	.	134409	0.05
chr12_6727682_6727833	0.15	CHD4	chromodomain helicase DNA binding protein 4	11115	0.08
chr7_158505623_158505780	0.15	NCAPG2	non-SMC condensin II complex, subunit G2	8181	0.23
chr6_6587145_6587296	0.15	LY86-AS1	LY86 antisense RNA 1	206	0.91
chr1_244481954_244482146	0.15	C1orf100	chromosome 1 open reading frame 100	33887	0.2
chr14_24041929_24042080	0.15	JPH4	junctophilin 4	206	0.88
chr14_70171005_70171156	0.15	SRSF5	serine/arginine-rich splicing factor 5	22537	0.21
chr17_76875045_76875748	0.15	TIMP2	TIMP metallopeptidase inhibitor 2	5164	0.16
chr8_134038596_134039031	0.15	TG	thyroglobulin	8869	0.25
chr3_58060016_58060182	0.15	FLNB	filamin B, beta	3957	0.31
chr19_44038735_44038963	0.15	ZNF575	zinc finger protein 575	1284	0.27
chr12_121136482_121136633	0.15	RP11-173P15.3		747	0.48
chr22_42095499_42095650	0.15	MEI1	meiosis inhibitor 1	56	0.95
chr19_7720613_7720936	0.15	STXBP2	syntaxin binding protein 2	9929	0.08
chr9_124048116_124048398	0.15	GSN-AS1	GSN antisense RNA 1	449	0.54
chr17_36582123_36582274	0.15	ARHGAP23	Rho GTPase activating protein 23	2464	0.24
chr14_54810734_54810960	0.15	CDKN3	cyclin-dependent kinase inhibitor 3	52826	0.16
chr13_101259048_101259199	0.15	GGACT	gamma-glutamylamine cyclotransferase	17341	0.19
chrX_123512646_123512832	0.15	SH2D1A	SH2 domain containing 1A	32300	0.24
chr12_111836596_111836747	0.15	SH2B3	SH2B adaptor protein 3	7081	0.19
chr13_24612924_24613153	0.14	SPATA13	spermatogenesis associated 13	59094	0.12
chr17_63367349_63367500	0.14	ENSG00000265189	.	49354	0.18
chr5_111089659_111089857	0.14	NREP	neuronal regeneration related protein	2190	0.34
chr8_125663658_125664035	0.14	RP11-532M24.1		71974	0.09
chr4_139327703_139328022	0.14	SLC7A11	solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11	164359	0.04
chr15_65871486_65871637	0.14	ENSG00000238715	.	8150	0.13
chr2_223733795_223733969	0.14	ACSL3	acyl-CoA synthetase long-chain family member 3	7601	0.24
chr3_13056298_13056451	0.14	IQSEC1	IQ motif and Sec7 domain 1	27838	0.23
chr17_26846701_26846852	0.14	FOXN1	forkhead box N1	4183	0.11
chr21_43728792_43729093	0.14	TFF3	trefoil factor 3 (intestinal)	6504	0.15
chr11_73083087_73083238	0.14	RELT	RELT tumor necrosis factor receptor	4147	0.17
chr6_26485880_26486031	0.14	BTN1A1	butyrophilin, subfamily 1, member A1	15494	0.11
chr8_59583399_59583550	0.14	ENSG00000238433	.	8571	0.23
chr1_159173730_159173881	0.14	DARC	Duffy blood group, atypical chemokine receptor	266	0.86
chr5_485358_485509	0.14	ENSG00000225138	.	8073	0.13
chr1_167073679_167073835	0.14	DUSP27	dual specificity phosphatase 27 (putative)	9670	0.17
chr3_29452909_29453060	0.14	ENSG00000216169	.	42072	0.2
chr3_69789465_69789616	0.14	MITF	microphthalmia-associated transcription factor	918	0.68
chr1_161038891_161039092	0.14	ARHGAP30	Rho GTPase activating protein 30	465	0.61
chr9_134752156_134752307	0.14	ENSG00000212395	.	93886	0.08
chr4_144296712_144296863	0.14	GAB1	GRB2-associated binding protein 1	1191	0.54
chr1_46032186_46032337	0.14	AKR1A1	aldo-keto reductase family 1, member A1 (aldehyde reductase)	15521	0.14
chr1_56942791_56942942	0.14	ENSG00000223307	.	99776	0.08
chr22_25128279_25128430	0.14	PIWIL3	piwi-like RNA-mediated gene silencing 3	42090	0.15
chr4_8404089_8404323	0.14	ENSG00000202054	.	9464	0.18
chr10_72271972_72272123	0.14	PALD1	phosphatase domain containing, paladin 1	33470	0.16
chr13_111169859_111170091	0.14	COL4A2-AS1	COL4A2 antisense RNA 1	9449	0.21
chr20_40072604_40072755	0.14	CHD6	chromodomain helicase DNA binding protein 6	55278	0.13
chr10_125826370_125826646	0.14	CHST15	carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15	20267	0.26
chr2_145237384_145237678	0.14	ZEB2	zinc finger E-box binding homeobox 2	37584	0.19
chr19_55142266_55142451	0.14	LILRB1	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1	167	0.89
chr3_185463236_185463533	0.14	ENSG00000265470	.	22308	0.19
chr18_22677589_22677740	0.14	ZNF521	zinc finger protein 521	127089	0.06
chr2_46574762_46574949	0.14	EPAS1	endothelial PAS domain protein 1	50314	0.15
chr12_48554479_48554630	0.14	ASB8	ankyrin repeat and SOCS box containing 8	3176	0.17
chr2_182284878_182285029	0.14	ITGA4	integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)	36981	0.21
chr8_105800425_105800620	0.14	ENSG00000263732	.	33119	0.24
chr20_19373243_19373394	0.14	ENSG00000221748	.	51378	0.16
chrX_77374906_77375064	0.14	PGK1	phosphoglycerate kinase 1	13126	0.23
chr6_6588189_6588340	0.14	LY86	lymphocyte antigen 86	77	0.94
chr18_46199452_46199714	0.14	ENSG00000266276	.	2612	0.32
chr5_373044_373258	0.14	AHRR	aryl-hydrocarbon receptor repressor	29508	0.14
chr10_97995296_97995447	0.14	BLNK	B-cell linker	35784	0.16
chr10_130978330_130978481	0.14	MGMT	O-6-methylguanine-DNA methyltransferase	287043	0.01
chr10_98524301_98524550	0.14	ENSG00000207287	.	21501	0.18
chr7_99797920_99798071	0.14	STAG3	stromal antigen 3	4901	0.09
chr11_2935428_2935683	0.14	SLC22A18AS	solute carrier family 22 (organic cation transporter), member 18 antisense	10585	0.11
chr18_60561889_60562040	0.14	PHLPP1	PH domain and leucine rich repeat protein phosphatase 1	8419	0.25
chr7_151542313_151542464	0.14	PRKAG2	protein kinase, AMP-activated, gamma 2 non-catalytic subunit	30462	0.13
chr14_100481690_100481841	0.14	EVL	Enah/Vasp-like	3954	0.23
chr22_27530704_27530861	0.13	ENSG00000200443	.	98932	0.09
chr2_136577229_136577614	0.13	AC011893.3		340	0.86
chr1_183880847_183880998	0.13	COLGALT2	collagen beta(1-O)galactosyltransferase 2	34830	0.2
chr18_35302652_35302803	0.13	ENSG00000266530	.	65629	0.15
chr5_39400930_39401193	0.13	DAB2	Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)	6559	0.27
chr9_94065201_94065395	0.13	AUH	AU RNA binding protein/enoyl-CoA hydratase	58879	0.16
chr7_132139041_132139287	0.13	AC011625.1		102071	0.08
chr1_27626590_27626805	0.13	TMEM222	transmembrane protein 222	21954	0.11
chr18_53780471_53780622	0.13	ENSG00000201816	.	33721	0.25
chr16_86632416_86632567	0.13	FOXL1	forkhead box L1	20376	0.17
chr11_71844321_71844472	0.13	FOLR3	folate receptor 3 (gamma)	2360	0.15
chr5_82297884_82298035	0.13	ENSG00000238835	.	62197	0.13

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of NANOG

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0032641	lymphotoxin A production(GO:0032641) lymphotoxin A biosynthetic process(GO:0042109)
0.0	0.2	GO:0045542	positive regulation of cholesterol biosynthetic process(GO:0045542)
0.0	0.1	GO:0072311	renal filtration cell differentiation(GO:0061318) glomerular epithelium development(GO:0072010) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.0	0.1	GO:0060298	positive regulation of sarcomere organization(GO:0060298)
0.0	0.1	GO:0051712	positive regulation of killing of cells of other organism(GO:0051712)
0.0	0.0	GO:0007621	negative regulation of female receptivity(GO:0007621)
0.0	0.1	GO:0010842	retina layer formation(GO:0010842)
0.0	0.0	GO:0006883	cellular sodium ion homeostasis(GO:0006883)
0.0	0.1	GO:0032509	endosome transport via multivesicular body sorting pathway(GO:0032509)
0.0	0.1	GO:0007028	cytoplasm organization(GO:0007028)
0.0	0.1	GO:0009648	photoperiodism(GO:0009648)
0.0	0.1	GO:0006562	proline catabolic process(GO:0006562)
0.0	0.1	GO:0051016	barbed-end actin filament capping(GO:0051016)
0.0	0.0	GO:0051709	regulation of killing of cells of other organism(GO:0051709)
0.0	0.1	GO:0010739	positive regulation of protein kinase A signaling(GO:0010739)
0.0	0.1	GO:0034720	histone H3-K4 demethylation(GO:0034720)
0.0	0.1	GO:0007185	transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0	0.2	GO:0007141	male meiosis I(GO:0007141)
0.0	0.1	GO:0035405	histone-threonine phosphorylation(GO:0035405)
0.0	0.1	GO:0030321	transepithelial chloride transport(GO:0030321)
0.0	0.1	GO:0030538	embryonic genitalia morphogenesis(GO:0030538)
0.0	0.1	GO:0031558	obsolete induction of apoptosis in response to chemical stimulus(GO:0031558)
0.0	0.0	GO:0003078	obsolete regulation of natriuresis(GO:0003078)
0.0	0.1	GO:0030854	positive regulation of granulocyte differentiation(GO:0030854)
0.0	0.0	GO:0070427	nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427)
0.0	0.1	GO:0060314	regulation of ryanodine-sensitive calcium-release channel activity(GO:0060314)
0.0	0.0	GO:0061030	epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.0	0.0	GO:0030210	heparin biosynthetic process(GO:0030210)
0.0	0.0	GO:0009138	pyrimidine nucleoside diphosphate metabolic process(GO:0009138)
0.0	0.1	GO:0060528	secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.0	0.1	GO:0046882	negative regulation of follicle-stimulating hormone secretion(GO:0046882)
0.0	0.0	GO:0021555	midbrain-hindbrain boundary morphogenesis(GO:0021555)
0.0	0.0	GO:0032959	inositol trisphosphate biosynthetic process(GO:0032959)
0.0	0.0	GO:0050651	dermatan sulfate proteoglycan biosynthetic process(GO:0050651)
0.0	0.0	GO:0071605	monocyte chemotactic protein-1 production(GO:0071605) regulation of monocyte chemotactic protein-1 production(GO:0071637)
0.0	0.0	GO:0032682	negative regulation of chemokine production(GO:0032682) negative regulation of chemokine biosynthetic process(GO:0045079)
0.0	0.0	GO:0042726	flavin-containing compound metabolic process(GO:0042726)
0.0	0.0	GO:0045163	clustering of voltage-gated potassium channels(GO:0045163)
0.0	0.1	GO:0045647	negative regulation of erythrocyte differentiation(GO:0045647)
0.0	0.0	GO:0034638	phosphatidylcholine catabolic process(GO:0034638)
0.0	0.0	GO:0042996	regulation of Golgi to plasma membrane protein transport(GO:0042996)
0.0	0.0	GO:0032071	regulation of endodeoxyribonuclease activity(GO:0032071)
0.0	0.1	GO:0051883	disruption of cells of other organism involved in symbiotic interaction(GO:0051818) killing of cells in other organism involved in symbiotic interaction(GO:0051883)
0.0	0.0	GO:0031223	auditory behavior(GO:0031223)
0.0	0.0	GO:0048149	behavioral response to ethanol(GO:0048149)
0.0	0.1	GO:0006198	cAMP catabolic process(GO:0006198)
0.0	0.1	GO:0030949	positive regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030949)
0.0	0.0	GO:0008588	release of cytoplasmic sequestered NF-kappaB(GO:0008588)
0.0	0.0	GO:0060235	lens induction in camera-type eye(GO:0060235)

Gene overrepresentation in cellular component category:

Total log-likelihood	Term	Description
0.1	GO:0014701	junctional sarcoplasmic reticulum membrane(GO:0014701)
0.1	GO:0042629	mast cell granule(GO:0042629)
0.1	GO:0045323	interleukin-1 receptor complex(GO:0045323)
0.1	GO:0031312	extrinsic component of organelle membrane(GO:0031312)
0.0	GO:0042825	TAP complex(GO:0042825)
0.1	GO:0071437	invadopodium(GO:0071437)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0004687	myosin light chain kinase activity(GO:0004687)
0.0	0.2	GO:0071553	uridine nucleotide receptor activity(GO:0015065) G-protein coupled pyrimidinergic nucleotide receptor activity(GO:0071553)
0.0	0.1	GO:0004768	stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215)
0.0	0.2	GO:0004957	prostaglandin E receptor activity(GO:0004957)
0.0	0.1	GO:0019956	chemokine binding(GO:0019956)
0.0	0.1	GO:0019863	IgE binding(GO:0019863)
0.0	0.1	GO:0008179	adenylate cyclase binding(GO:0008179)
0.0	0.1	GO:0003836	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0	0.2	GO:0019864	IgG binding(GO:0019864)
0.0	0.1	GO:0034648	histone demethylase activity (H3-K4 specific)(GO:0032453) histone demethylase activity (H3-dimethyl-K4 specific)(GO:0034648)
0.0	0.1	GO:0048406	nerve growth factor binding(GO:0048406)
0.0	0.1	GO:0035184	histone threonine kinase activity(GO:0035184)
0.0	0.1	GO:0004720	protein-lysine 6-oxidase activity(GO:0004720)
0.0	0.1	GO:0016494	C-X-C chemokine receptor activity(GO:0016494)
0.0	0.0	GO:0046980	tapasin binding(GO:0046980)
0.0	0.1	GO:0016653	oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor(GO:0016653)
0.0	0.2	GO:0001871	pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0	0.0	GO:0050693	LBD domain binding(GO:0050693)
0.0	0.0	GO:0004955	prostaglandin receptor activity(GO:0004955)
0.0	0.1	GO:0004908	interleukin-1 receptor activity(GO:0004908)
0.0	0.1	GO:0030676	Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0	0.0	GO:0003829	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0003829)
0.0	0.1	GO:0003688	DNA replication origin binding(GO:0003688)
0.0	0.0	GO:0000987	RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.0	0.0	GO:0042910	xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.0	0.1	GO:0019992	diacylglycerol binding(GO:0019992)
0.0	0.0	GO:0043398	HLH domain binding(GO:0043398)
0.0	0.0	GO:0045236	CXCR chemokine receptor binding(GO:0045236)
0.0	0.0	GO:0016774	phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.0	0.0	GO:0050544	arachidonic acid binding(GO:0050544)
0.0	0.0	GO:0004321	fatty-acyl-CoA synthase activity(GO:0004321)
0.0	0.1	GO:0004887	thyroid hormone receptor activity(GO:0004887)
0.0	0.1	GO:0008273	calcium, potassium:sodium antiporter activity(GO:0008273)
0.0	0.1	GO:0005132	type I interferon receptor binding(GO:0005132)
0.0	0.1	GO:0008191	metalloendopeptidase inhibitor activity(GO:0008191)
0.0	0.0	GO:0005250	A-type (transient outward) potassium channel activity(GO:0005250)
0.0	0.0	GO:0047115	trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity(GO:0047115)
0.0	0.1	GO:0070087	chromo shadow domain binding(GO:0070087)
0.0	0.0	GO:0047756	chondroitin 4-sulfotransferase activity(GO:0047756)
0.0	0.0	GO:0005346	purine ribonucleotide transmembrane transporter activity(GO:0005346)
0.0	0.0	GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717)
0.0	0.0	GO:0004886	9-cis retinoic acid receptor activity(GO:0004886)
0.0	0.2	GO:0047555	3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.0	0.2	GO:0015026	coreceptor activity(GO:0015026)
0.0	0.1	GO:0005522	profilin binding(GO:0005522)
0.0	0.0	GO:0031685	adenosine receptor binding(GO:0031685)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.0	PID TXA2PATHWAY	Thromboxane A2 receptor signaling
0.0	PID ERBB4 PATHWAY	ErbB4 signaling events
0.1	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0	PID ECADHERIN KERATINOCYTE PATHWAY	E-cadherin signaling in keratinocytes

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.0	REACTOME PLC BETA MEDIATED EVENTS	Genes involved in PLC beta mediated events
0.2	REACTOME PROSTANOID LIGAND RECEPTORS	Genes involved in Prostanoid ligand receptors
0.1	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.2	REACTOME SIGNALING BY FGFR3 MUTANTS	Genes involved in Signaling by FGFR3 mutants
0.1	REACTOME PHOSPHOLIPASE C MEDIATED CASCADE	Genes involved in Phospholipase C-mediated cascade
0.2	REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS	Genes involved in Nucleotide-like (purinergic) receptors
0.2	REACTOME CGMP EFFECTS	Genes involved in cGMP effects
0.1	REACTOME CD28 DEPENDENT VAV1 PATHWAY	Genes involved in CD28 dependent Vav1 pathway
0.0	REACTOME G ALPHA Z SIGNALLING EVENTS	Genes involved in G alpha (z) signalling events