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ENCODE: H3K4me1 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for NFAT5

Z-value: 1.03

Motif logo

Transcription factors associated with NFAT5

Gene Symbol	Gene ID	Gene Info
NFAT5 Ensembl NCBI GeneCards UniProt	ENSG00000102908.16	NFAT5

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
NFAT5	chr16_69653321_69653472	27639	0.149140	0.96	2.6e-05	Click!
NFAT5	chr16_69653099_69653250	27861	0.148694	0.95	7.6e-05	Click!
NFAT5	chr16_69600802_69601252	773	0.528857	0.80	1.0e-02	Click!
NFAT5	chr16_69652942_69653093	28018	0.148377	0.71	3.3e-02	Click!
NFAT5	chr16_69568902_69569053	30020	0.146465	-0.70	3.6e-02	Click!

Activity of the NFAT5 motif across conditions

Conditions sorted by the z-value of the NFAT5 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr9_134546803_134547477	0.38	RAPGEF1	Rap guanine nucleotide exchange factor (GEF) 1	38089	0.16
chrX_128904932_128905357	0.38	SASH3	SAM and SH3 domain containing 3	8816	0.2
chr1_226913224_226913375	0.36	ITPKB	inositol-trisphosphate 3-kinase B	11860	0.22
chr18_3060720_3060948	0.36	ENSG00000252353	.	32732	0.14
chr8_82053234_82053464	0.34	PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	29046	0.23
chr1_100908166_100908711	0.33	RP5-837M10.4		43115	0.14
chr17_1775725_1776037	0.33	RPA1	replication protein A1, 70kDa	6448	0.16
chr6_143173861_143174012	0.33	HIVEP2	human immunodeficiency virus type I enhancer binding protein 2	15752	0.27
chr1_206740198_206740524	0.32	RASSF5	Ras association (RalGDS/AF-6) domain family member 5	9868	0.16
chr3_68135261_68135467	0.32	FAM19A1	family with sequence similarity 19 (chemokine (C-C motif)-like), member A1	79991	0.12
chr14_63979608_63979759	0.31	PPP2R5E	protein phosphatase 2, regulatory subunit B', epsilon isoform	4728	0.18
chr8_87359664_87359960	0.31	WWP1	WW domain containing E3 ubiquitin protein ligase 1	4845	0.3
chr3_33087403_33087747	0.31	GLB1	galactosidase, beta 1	50709	0.11
chr2_136969948_136970391	0.30	CXCR4	chemokine (C-X-C motif) receptor 4	94434	0.09
chr2_207306958_207307129	0.30	ADAM23	ADAM metallopeptidase domain 23	1220	0.57
chrX_152603176_152603363	0.30	ZNF275	zinc finger protein 275	3656	0.21
chr10_111830389_111830580	0.30	ADD3	adducin 3 (gamma)	62762	0.11
chr5_95151283_95151599	0.29	GLRX	glutaredoxin (thioltransferase)	6974	0.16
chr4_40190799_40190950	0.29	RHOH	ras homolog family member H	1799	0.37
chr18_2961462_2961796	0.29	RP11-737O24.1		5387	0.16
chr12_54893042_54893194	0.28	NCKAP1L	NCK-associated protein 1-like	550	0.7
chr16_68107852_68108775	0.28	NFATC3	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3	10934	0.1
chr5_49659303_49659576	0.28	EMB	embigin	65122	0.15
chr14_51279547_51280135	0.28	RP11-286O18.1		8757	0.15
chr6_144682280_144682476	0.28	UTRN	utrophin	17141	0.24
chr15_66110664_66110894	0.27	ENSG00000252715	.	25043	0.14
chr8_38790336_38790830	0.27	PLEKHA2	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2	31721	0.12
chr8_134538342_134538795	0.27	ST3GAL1	ST3 beta-galactoside alpha-2,3-sialyltransferase 1	26942	0.25
chr2_198189379_198189688	0.27	AC010746.3		13416	0.15
chr7_144527992_144528143	0.26	TPK1	thiamin pyrophosphokinase 1	5079	0.28
chr14_55178975_55179167	0.26	SAMD4A	sterile alpha motif domain containing 4A	42480	0.18
chr7_138768806_138768957	0.26	ZC3HAV1	zinc finger CCCH-type, antiviral 1	4868	0.24
chr11_35268427_35268939	0.26	SLC1A2	solute carrier family 1 (glial high affinity glutamate transporter), member 2	18609	0.14
chr11_128645048_128645199	0.26	FLI1	Fli-1 proto-oncogene, ETS transcription factor	10438	0.22
chr12_9805985_9806454	0.26	RP11-705C15.2		60	0.96
chr10_22902783_22903038	0.26	PIP4K2A	phosphatidylinositol-5-phosphate 4-kinase, type II, alpha	22268	0.26
chr6_138196299_138196450	0.26	RP11-356I2.4		7004	0.23
chr10_4023787_4024265	0.26	KLF6	Kruppel-like factor 6	196553	0.03
chr20_57695964_57696140	0.26	ZNF831	zinc finger protein 831	70023	0.09
chr1_2206148_2206653	0.26	SKI	v-ski avian sarcoma viral oncogene homolog	46266	0.08
chr17_17087488_17087777	0.25	RP11-45M22.3		1236	0.32
chr2_204583285_204583561	0.25	CD28	CD28 molecule	12007	0.23
chr11_57443281_57443465	0.25	ZDHHC5	zinc finger, DHHC-type containing 5	2757	0.15
chr1_66836429_66836594	0.25	PDE4B	phosphodiesterase 4B, cAMP-specific	16446	0.28
chr3_16356399_16356550	0.25	RP11-415F23.2		528	0.76
chr11_6770543_6770694	0.25	OR2AG2	olfactory receptor, family 2, subfamily AG, member 2	19668	0.11
chr14_61763065_61763216	0.25	TMEM30B	transmembrane protein 30B	14582	0.17
chr1_92876308_92876612	0.24	ENSG00000242764	.	8218	0.25
chr10_11241753_11242016	0.24	RP3-323N1.2		28545	0.19
chr2_148257449_148257801	0.24	ENSG00000202074	.	4517	0.24
chr7_100147991_100148484	0.24	AGFG2	ArfGAP with FG repeats 2	5053	0.1
chr2_223169089_223169702	0.24	CCDC140	coiled-coil domain containing 140	1698	0.35
chr18_13615466_13615831	0.24	LDLRAD4	low density lipoprotein receptor class A domain containing 4	3030	0.17
chr17_20179870_20180077	0.24	ENSG00000252971	.	13597	0.17
chr1_202134842_202135197	0.24	PTPN7	protein tyrosine phosphatase, non-receptor type 7	4303	0.16
chr5_156650274_156650456	0.24	CTB-4E7.1		1025	0.44
chr16_85481767_85482285	0.24	ENSG00000264203	.	6928	0.27
chr2_10520453_10520734	0.23	HPCAL1	hippocalcin-like 1	39554	0.14
chr1_167453393_167453610	0.23	RP11-104L21.2		25603	0.17
chr8_134578488_134578789	0.23	ST3GAL1	ST3 beta-galactoside alpha-2,3-sialyltransferase 1	5454	0.32
chr4_109081982_109082160	0.23	LEF1	lymphoid enhancer-binding factor 1	5386	0.25
chr5_66453399_66453643	0.23	MAST4	microtubule associated serine/threonine kinase family member 4	15259	0.25
chr5_85334298_85334449	0.23	NBPF22P	neuroblastoma breakpoint family, member 22, pseudogene	244211	0.02
chr12_132092633_132092991	0.23	ENSG00000212154	.	52796	0.15
chr3_16353015_16353233	0.23	RP11-415F23.2		2822	0.24
chr1_120684562_120684908	0.23	ENSG00000207149	.	15173	0.24
chr18_46311251_46311510	0.23	RP11-484L8.1		49761	0.15
chr3_33058315_33058653	0.23	CCR4	chemokine (C-C motif) receptor 4	65418	0.1
chr12_57868027_57868178	0.23	ARHGAP9	Rho GTPase activating protein 9	615	0.5
chr8_60010060_60010211	0.22	RP11-25K19.1		21464	0.19
chr11_36472075_36472226	0.22	RP11-219O3.2		24478	0.18
chr17_37251149_37251404	0.22	PLXDC1	plexin domain containing 1	12464	0.15
chr2_30559818_30559976	0.22	ENSG00000221377	.	95417	0.07
chrX_128921294_128921545	0.22	SASH3	SAM and SH3 domain containing 3	7459	0.2
chr3_3213200_3213369	0.22	CRBN	cereblon	8074	0.19
chr12_112440617_112440858	0.22	TMEM116	transmembrane protein 116	3052	0.22
chr14_53773006_53773157	0.22	RP11-547D23.1		153009	0.04
chr16_80625275_80625613	0.22	RP11-525K10.3		28412	0.14
chr8_26171540_26171691	0.22	PPP2R2A	protein phosphatase 2, regulatory subunit B, alpha	20616	0.23
chr12_28404046_28404197	0.22	CCDC91	coiled-coil domain containing 91	5537	0.28
chr2_42523029_42523463	0.22	EML4	echinoderm microtubule associated protein like 4	5147	0.28
chr6_152011555_152011706	0.22	ESR1	estrogen receptor 1	1	0.99
chr16_88759405_88759694	0.22	RP5-1142A6.5		3360	0.09
chr6_108043823_108043992	0.22	SCML4	sex comb on midleg-like 4 (Drosophila)	9692	0.29
chrX_49148626_49148900	0.22	GAGE10	G antigen 10	11385	0.08
chr1_198590725_198590954	0.21	PTPRC	protein tyrosine phosphatase, receptor type, C	16962	0.24
chr13_51464563_51464756	0.21	RNASEH2B-AS1	RNASEH2B antisense RNA 1	1119	0.51
chr19_41807008_41807159	0.21	CCDC97	coiled-coil domain containing 97	9011	0.11
chr7_44681338_44681649	0.21	OGDH	oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)	17432	0.18
chr20_47391272_47391546	0.21	ENSG00000251876	.	35424	0.19
chr10_14625977_14626446	0.21	FAM107B	family with sequence similarity 107, member B	11873	0.24
chr12_92899152_92899351	0.21	ENSG00000238865	.	39512	0.17
chr3_33472190_33472341	0.21	UBP1	upstream binding protein 1 (LBP-1a)	9237	0.21
chr4_3203376_3203582	0.21	HTT	huntingtin	41390	0.15
chr6_11211149_11211363	0.21	NEDD9	neural precursor cell expressed, developmentally down-regulated 9	21635	0.19
chr14_91769117_91769483	0.21	CCDC88C	coiled-coil domain containing 88C	17288	0.17
chr13_100037229_100037523	0.21	ENSG00000207719	.	28991	0.17
chr2_158327174_158327325	0.21	CYTIP	cytohesin 1 interacting protein	18092	0.22
chr12_123712658_123712809	0.21	MPHOSPH9	M-phase phosphoprotein 9	2260	0.21
chr2_231457387_231457706	0.21	ENSG00000199791	.	5710	0.22
chr10_17725949_17726205	0.21	ENSG00000251959	.	4890	0.18
chr16_53948312_53948589	0.21	FTO	fat mass and obesity associated	3282	0.32
chrX_134517228_134517850	0.21	ZNF449	zinc finger protein 449	38818	0.14
chr16_29826201_29826393	0.20	PAGR1	PAXIP1 associated glutamate-rich protein 1	988	0.24
chr13_52527282_52527433	0.20	ATP7B	ATPase, Cu++ transporting, beta polypeptide	8694	0.22
chr3_150923497_150923774	0.20	GPR171	G protein-coupled receptor 171	2647	0.22
chr12_47758069_47758220	0.20	ENSG00000264906	.	92	0.98
chr9_92137029_92137304	0.20	SEMA4D	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D	24121	0.2
chr7_37405451_37405685	0.20	ELMO1	engulfment and cell motility 1	12296	0.2
chr7_151049124_151049275	0.20	NUB1	negative regulator of ubiquitin-like proteins 1	6768	0.16
chr1_169659993_169660655	0.20	SELL	selectin L	20515	0.18
chr7_50321524_50321798	0.20	IKZF1	IKAROS family zinc finger 1 (Ikaros)	22663	0.25
chr22_23132033_23132342	0.20	ENSG00000207833	.	2790	0.07
chr14_66394986_66395728	0.20	CTD-2014B16.3	Uncharacterized protein	75884	0.11
chr6_37476350_37476501	0.20	CCDC167	coiled-coil domain containing 167	8727	0.21
chr5_54333803_54333961	0.20	ENSG00000207229	.	2793	0.19
chr2_106755042_106755216	0.20	UXS1	UDP-glucuronate decarboxylase 1	113	0.98
chr3_71755190_71755341	0.20	EIF4E3	eukaryotic translation initiation factor 4E family member 3	19261	0.21
chr1_151797364_151797736	0.20	RORC	RAR-related orphan receptor C	1017	0.29
chr5_156451707_156451858	0.20	HAVCR1	hepatitis A virus cellular receptor 1	33625	0.15
chr17_77803360_77803511	0.20	CBX4	chromobox homolog 4	8245	0.15
chr19_42945492_42946028	0.20	CXCL17	chemokine (C-X-C motif) ligand 17	1440	0.28
chr6_11717864_11718015	0.20	ENSG00000207419	.	7887	0.25
chr17_48986753_48987319	0.20	TOB1	transducer of ERBB2, 1	41697	0.12
chr1_40850590_40850842	0.20	SMAP2	small ArfGAP2	10396	0.17
chr6_31740986_31741137	0.20	VWA7	von Willebrand factor A domain containing 7	4010	0.06
chr11_95951199_95951370	0.20	ENSG00000266192	.	123318	0.06
chr8_117133446_117133597	0.20	ENSG00000221793	.	15477	0.28
chr11_128293469_128293620	0.20	ETS1	v-ets avian erythroblastosis virus E26 oncogene homolog 1	81745	0.1
chr3_28337245_28337396	0.20	AZI2	5-azacytidine induced 2	36578	0.17
chr6_16421963_16422331	0.20	ENSG00000265642	.	6607	0.32
chr6_151693582_151694001	0.20	ENSG00000252615	.	5443	0.15
chr16_3554613_3554882	0.20	CLUAP1	clusterin associated protein 1	2703	0.18
chr8_134512123_134512433	0.20	ST3GAL1	ST3 beta-galactoside alpha-2,3-sialyltransferase 1	652	0.83
chr6_130040950_130041101	0.20	ARHGAP18	Rho GTPase activating protein 18	9655	0.25
chr12_110787824_110788162	0.20	ATP2A2	ATPase, Ca++ transporting, cardiac muscle, slow twitch 2	3987	0.2
chr21_15894298_15894574	0.20	SAMSN1	SAM domain, SH3 domain and nuclear localization signals 1	24226	0.22
chr3_16355269_16355595	0.20	RP11-415F23.2		514	0.77
chr18_60981487_60981741	0.20	RP11-28F1.2		299	0.89
chr21_19155131_19155430	0.20	AL109761.5		10525	0.23
chrX_135960364_135960605	0.20	ENSG00000206979	.	946	0.43
chr12_121333840_121333991	0.19	SPPL3	signal peptide peptidase like 3	7258	0.19
chr12_121677712_121677919	0.19	CAMKK2	calcium/calmodulin-dependent protein kinase kinase 2, beta	20530	0.16
chr14_91798820_91799198	0.19	ENSG00000265856	.	1048	0.58
chr10_73839065_73839273	0.19	SPOCK2	sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2	8917	0.24
chr5_50010543_50010746	0.19	PARP8	poly (ADP-ribose) polymerase family, member 8	47253	0.2
chr21_46686004_46686155	0.19	POFUT2	protein O-fucosyltransferase 2	19527	0.17
chr4_76860371_76860572	0.19	NAAA	N-acylethanolamine acid amidase	942	0.47
chr10_112602586_112603108	0.19	PDCD4	programmed cell death 4 (neoplastic transformation inhibitor)	28718	0.13
chr1_108327675_108328746	0.19	ENSG00000265536	.	9332	0.26
chrX_41641506_41641657	0.19	GPR82	G protein-coupled receptor 82	58173	0.13
chr3_183067564_183068011	0.19	MCF2L2	MCF.2 cell line derived transforming sequence-like 2	77978	0.07
chr9_14314790_14315056	0.19	NFIB	nuclear factor I/B	342	0.89
chr10_22030567_22030830	0.19	ENSG00000252634	.	43523	0.16
chr12_68025335_68025706	0.19	DYRK2	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2	16598	0.25
chr7_149565914_149566574	0.19	ATP6V0E2	ATPase, H+ transporting V0 subunit e2	3813	0.19
chr10_126384949_126385100	0.19	FAM53B-AS1	FAM53B antisense RNA 1	7170	0.22
chr3_33096251_33096868	0.19	GLB1	galactosidase, beta 1	41725	0.12
chr10_11241276_11241580	0.19	RP3-323N1.2		28089	0.19
chr15_61135175_61135326	0.19	RP11-554D20.1		78311	0.11
chr18_2958940_2959410	0.19	RP11-737O24.1		7841	0.15
chr6_27122996_27123197	0.19	ENSG00000265565	.	7691	0.12
chrX_154492108_154492373	0.19	RAB39B	RAB39B, member RAS oncogene family	1634	0.36
chr4_120202212_120202363	0.19	C4orf3	chromosome 4 open reading frame 3	19789	0.17
chrX_128912114_128912265	0.19	SASH3	SAM and SH3 domain containing 3	1771	0.37
chr2_84743044_84743233	0.19	DNAH6	dynein, axonemal, heavy chain 6	441	0.89
chr14_99688948_99689139	0.19	AL109767.1		40242	0.16
chr18_18673078_18673254	0.19	ROCK1	Rho-associated, coiled-coil containing protein kinase 1	18646	0.19
chr16_79311831_79311982	0.19	ENSG00000222244	.	13555	0.29
chr14_76017369_76017520	0.19	FLVCR2	feline leukemia virus subgroup C cellular receptor family, member 2	27516	0.13
chr14_92469799_92469950	0.19	TRIP11	thyroid hormone receptor interactor 11	12221	0.18
chr15_44963811_44964098	0.19	PATL2	protein associated with topoisomerase II homolog 2 (yeast)	3271	0.19
chr10_104411938_104412104	0.19	TRIM8	tripartite motif containing 8	7377	0.18
chr12_9853577_9853728	0.18	CLEC2D	C-type lectin domain family 2, member D	13155	0.13
chr2_65255557_65255797	0.18	AC007386.4		8954	0.17
chr19_54876287_54876508	0.18	LAIR1	leukocyte-associated immunoglobulin-like receptor 1	17	0.96
chr13_41188048_41188199	0.18	FOXO1	forkhead box O1	52611	0.14
chr1_151593899_151594050	0.18	ENSG00000206635	.	7826	0.11
chr3_56836593_56836843	0.18	ARHGEF3	Rho guanine nucleotide exchange factor (GEF) 3	723	0.78
chr14_92329341_92329492	0.18	TC2N	tandem C2 domains, nuclear	4457	0.23
chr1_24851023_24851224	0.18	ENSG00000266551	.	5081	0.18
chr4_38513354_38513505	0.18	RP11-617D20.1		112767	0.06
chr2_158277456_158277614	0.18	CYTIP	cytohesin 1 interacting protein	18391	0.2
chr15_86243586_86243737	0.18	RP11-815J21.1		679	0.57
chr17_15847097_15847248	0.18	ADORA2B	adenosine A2b receptor	1059	0.53
chr3_45989617_45989903	0.18	CXCR6	chemokine (C-X-C motif) receptor 6	3219	0.21
chr20_37503628_37504045	0.18	ENSG00000240474	.	2423	0.3
chr6_11714882_11715244	0.18	ENSG00000207419	.	5011	0.27
chr11_69078676_69078863	0.18	MYEOV	myeloma overexpressed	17144	0.27
chr8_126661069_126661220	0.18	ENSG00000266452	.	204337	0.03
chr1_213245297_213245448	0.18	RPS6KC1	ribosomal protein S6 kinase, 52kDa, polypeptide 1	20768	0.23
chr8_23107497_23107648	0.18	CHMP7	charged multivesicular body protein 7	3400	0.16
chr17_46912636_46912982	0.18	CALCOCO2	calcium binding and coiled-coil domain 2	4219	0.14
chr3_150600490_150600641	0.18	RP11-166N6.2		7858	0.16
chr1_26003341_26003560	0.18	RP1-187B23.1		17848	0.17
chr8_129595182_129595552	0.18	ENSG00000221351	.	236673	0.02
chr1_84902550_84902701	0.18	DNASE2B	deoxyribonuclease II beta	28712	0.16
chr13_48762180_48762745	0.18	ITM2B	integral membrane protein 2B	44832	0.16
chr15_99600402_99600553	0.18	SYNM	synemin, intermediate filament protein	37943	0.12
chr3_152018760_152019009	0.18	MBNL1	muscleblind-like splicing regulator 1	897	0.64

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of NFAT5

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0030223	neutrophil differentiation(GO:0030223)
0.1	0.3	GO:0045589	regulation of regulatory T cell differentiation(GO:0045589)
0.1	0.3	GO:0001911	negative regulation of leukocyte mediated cytotoxicity(GO:0001911)
0.1	0.2	GO:0030011	maintenance of cell polarity(GO:0030011)
0.1	0.2	GO:0060750	epithelial cell proliferation involved in mammary gland duct elongation(GO:0060750)
0.1	0.1	GO:0002713	negative regulation of B cell mediated immunity(GO:0002713) negative regulation of immunoglobulin mediated immune response(GO:0002890)
0.1	0.2	GO:0048388	endosomal lumen acidification(GO:0048388)
0.1	0.2	GO:0045066	regulatory T cell differentiation(GO:0045066)
0.1	0.6	GO:0030206	chondroitin sulfate biosynthetic process(GO:0030206)
0.1	0.4	GO:0006198	cAMP catabolic process(GO:0006198)
0.1	0.3	GO:0002726	positive regulation of T cell cytokine production(GO:0002726)
0.1	0.1	GO:0048537	mucosal-associated lymphoid tissue development(GO:0048537)
0.1	0.2	GO:0090292	nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0	0.1	GO:0006772	thiamine metabolic process(GO:0006772)
0.0	0.1	GO:0006154	adenosine catabolic process(GO:0006154)
0.0	0.1	GO:0035405	histone-threonine phosphorylation(GO:0035405)
0.0	0.1	GO:0030854	positive regulation of granulocyte differentiation(GO:0030854)
0.0	0.1	GO:0031580	membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.0	0.1	GO:0002677	negative regulation of chronic inflammatory response(GO:0002677)
0.0	0.0	GO:0043368	positive T cell selection(GO:0043368)
0.0	0.2	GO:0033152	immunoglobulin V(D)J recombination(GO:0033152)
0.0	0.2	GO:0002313	mature B cell differentiation involved in immune response(GO:0002313) mature B cell differentiation(GO:0002335)
0.0	0.2	GO:0070670	response to interleukin-4(GO:0070670)
0.0	0.2	GO:0048096	chromatin-mediated maintenance of transcription(GO:0048096)
0.0	0.1	GO:0042091	interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.0	0.2	GO:0045059	positive thymic T cell selection(GO:0045059)
0.0	0.1	GO:0000042	protein targeting to Golgi(GO:0000042) establishment of protein localization to Golgi(GO:0072600)
0.0	0.1	GO:0045722	positive regulation of gluconeogenesis(GO:0045722)
0.0	0.2	GO:0046827	positive regulation of protein export from nucleus(GO:0046827)
0.0	0.0	GO:0070669	response to interleukin-2(GO:0070669)
0.0	0.1	GO:0060413	atrial septum development(GO:0003283) atrial septum morphogenesis(GO:0060413)
0.0	0.1	GO:0033262	regulation of nuclear cell cycle DNA replication(GO:0033262)
0.0	0.1	GO:0009313	oligosaccharide catabolic process(GO:0009313)
0.0	0.2	GO:0016553	base conversion or substitution editing(GO:0016553)
0.0	0.1	GO:0060437	lung growth(GO:0060437)
0.0	0.1	GO:0070172	positive regulation of tooth mineralization(GO:0070172)
0.0	0.1	GO:0032237	activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0	0.3	GO:0000381	regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0	0.1	GO:0002678	positive regulation of chronic inflammatory response(GO:0002678)
0.0	0.0	GO:0060557	positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559)
0.0	0.1	GO:0060676	ureteric bud formation(GO:0060676)
0.0	0.1	GO:0044332	Wnt signaling pathway involved in dorsal/ventral axis specification(GO:0044332) regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000053)
0.0	0.1	GO:0010536	regulation of activation of Janus kinase activity(GO:0010533) positive regulation of activation of Janus kinase activity(GO:0010536)
0.0	0.1	GO:0034135	regulation of toll-like receptor 2 signaling pathway(GO:0034135)
0.0	0.1	GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.0	0.1	GO:0046398	UDP-glucuronate biosynthetic process(GO:0006065) UDP-glucuronate metabolic process(GO:0046398)
0.0	0.0	GO:0071801	regulation of podosome assembly(GO:0071801) positive regulation of podosome assembly(GO:0071803)
0.0	0.2	GO:0050901	leukocyte tethering or rolling(GO:0050901) leukocyte adhesion to vascular endothelial cell(GO:0061756)
0.0	0.0	GO:0034776	response to histamine(GO:0034776)
0.0	0.1	GO:0046137	negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137)
0.0	0.3	GO:0043550	regulation of lipid kinase activity(GO:0043550)
0.0	0.1	GO:0090322	regulation of superoxide metabolic process(GO:0090322)
0.0	0.2	GO:0002360	T cell lineage commitment(GO:0002360)
0.0	0.1	GO:0060594	mammary gland specification(GO:0060594)
0.0	0.2	GO:0007172	signal complex assembly(GO:0007172)
0.0	0.1	GO:0060040	retinal bipolar neuron differentiation(GO:0060040)
0.0	0.1	GO:0009143	nucleoside triphosphate catabolic process(GO:0009143)
0.0	0.1	GO:1901985	positive regulation of histone acetylation(GO:0035066) positive regulation of protein acetylation(GO:1901985) positive regulation of peptidyl-lysine acetylation(GO:2000758)
0.0	0.1	GO:0048791	calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0	0.1	GO:0006922	obsolete cleavage of lamin involved in execution phase of apoptosis(GO:0006922)
0.0	0.1	GO:0019987	obsolete negative regulation of anti-apoptosis(GO:0019987)
0.0	0.1	GO:0006089	lactate metabolic process(GO:0006089)
0.0	0.2	GO:0045885	obsolete positive regulation of survival gene product expression(GO:0045885)
0.0	0.1	GO:0002407	dendritic cell chemotaxis(GO:0002407) dendritic cell migration(GO:0036336)
0.0	0.0	GO:0090047	obsolete positive regulation of transcription regulator activity(GO:0090047)
0.0	0.1	GO:0006564	L-serine biosynthetic process(GO:0006564)
0.0	0.0	GO:0071637	heterotypic cell-cell adhesion(GO:0034113) regulation of heterotypic cell-cell adhesion(GO:0034114) monocyte chemotactic protein-1 production(GO:0071605) regulation of monocyte chemotactic protein-1 production(GO:0071637)
0.0	0.2	GO:0019059	obsolete initiation of viral infection(GO:0019059)
0.0	0.0	GO:0032713	negative regulation of interleukin-4 production(GO:0032713)
0.0	0.1	GO:0072531	pyrimidine-containing compound transmembrane transport(GO:0072531)
0.0	0.0	GO:0042695	thelarche(GO:0042695) mammary gland branching involved in thelarche(GO:0060744)
0.0	0.1	GO:0008053	mitochondrial fusion(GO:0008053)
0.0	0.0	GO:0031223	auditory behavior(GO:0031223)
0.0	0.1	GO:0010829	negative regulation of glucose transport(GO:0010829) negative regulation of glucose import(GO:0046325)
0.0	0.1	GO:0010614	negative regulation of cardiac muscle hypertrophy(GO:0010614)
0.0	0.1	GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518) negative regulation of signal transduction by p53 class mediator(GO:1901797)
0.0	0.1	GO:0035455	response to interferon-alpha(GO:0035455)
0.0	0.2	GO:0006554	lysine metabolic process(GO:0006553) lysine catabolic process(GO:0006554)
0.0	0.0	GO:0045341	MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343)
0.0	0.2	GO:0001782	B cell homeostasis(GO:0001782)
0.0	0.1	GO:0031062	positive regulation of histone methylation(GO:0031062)
0.0	0.1	GO:0010447	response to acidic pH(GO:0010447)
0.0	0.2	GO:0002837	regulation of response to tumor cell(GO:0002834) positive regulation of response to tumor cell(GO:0002836) regulation of immune response to tumor cell(GO:0002837) positive regulation of immune response to tumor cell(GO:0002839)
0.0	0.1	GO:0009048	dosage compensation by inactivation of X chromosome(GO:0009048)
0.0	0.0	GO:0030505	inorganic diphosphate transport(GO:0030505)
0.0	0.0	GO:0033622	integrin activation(GO:0033622)
0.0	0.1	GO:0071364	cellular response to epidermal growth factor stimulus(GO:0071364)
0.0	0.1	GO:0032695	negative regulation of interleukin-12 production(GO:0032695)
0.0	1.2	GO:0031294	lymphocyte costimulation(GO:0031294) T cell costimulation(GO:0031295)
0.0	0.0	GO:0001916	regulation of T cell mediated cytotoxicity(GO:0001914) positive regulation of T cell mediated cytotoxicity(GO:0001916)
0.0	0.0	GO:0002043	blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.0	0.2	GO:0008635	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c(GO:0008635)
0.0	0.0	GO:0010592	positive regulation of lamellipodium assembly(GO:0010592) positive regulation of lamellipodium organization(GO:1902745)
0.0	0.1	GO:0035025	positive regulation of Rho protein signal transduction(GO:0035025)
0.0	0.1	GO:0008216	spermidine metabolic process(GO:0008216)
0.0	0.1	GO:0015801	aromatic amino acid transport(GO:0015801)
0.0	0.1	GO:0022614	membrane to membrane docking(GO:0022614)
0.0	0.0	GO:0007549	dosage compensation(GO:0007549)
0.0	0.1	GO:0018119	protein nitrosylation(GO:0017014) peptidyl-cysteine S-nitrosylation(GO:0018119)
0.0	0.2	GO:0043508	negative regulation of JUN kinase activity(GO:0043508)
0.0	0.1	GO:0022038	corpus callosum development(GO:0022038)
0.0	0.0	GO:0030202	heparin metabolic process(GO:0030202)
0.0	0.1	GO:0007191	adenylate cyclase-activating dopamine receptor signaling pathway(GO:0007191)
0.0	0.1	GO:0060049	regulation of protein glycosylation(GO:0060049)
0.0	0.1	GO:0032897	negative regulation of viral transcription(GO:0032897)
0.0	0.0	GO:0071360	cellular response to exogenous dsRNA(GO:0071360)
0.0	0.1	GO:0006384	transcription initiation from RNA polymerase III promoter(GO:0006384)
0.0	0.1	GO:0060235	lens induction in camera-type eye(GO:0060235)
0.0	0.1	GO:0003323	type B pancreatic cell development(GO:0003323)
0.0	0.1	GO:0021570	rhombomere 4 development(GO:0021570)
0.0	0.1	GO:0030187	melatonin metabolic process(GO:0030186) melatonin biosynthetic process(GO:0030187)
0.0	0.1	GO:0035511	oxidative DNA demethylation(GO:0035511)
0.0	0.1	GO:0033169	histone H3-K9 demethylation(GO:0033169)
0.0	0.0	GO:0010511	regulation of phosphatidylinositol biosynthetic process(GO:0010511)
0.0	0.0	GO:0072161	mesenchymal cell differentiation involved in kidney development(GO:0072161) metanephric mesenchymal cell differentiation(GO:0072162) mesenchymal cell differentiation involved in renal system development(GO:2001012)
0.0	0.1	GO:0032236	obsolete positive regulation of calcium ion transport via store-operated calcium channel activity(GO:0032236)
0.0	0.0	GO:0021561	facial nerve development(GO:0021561)
0.0	0.1	GO:0009698	phenylpropanoid metabolic process(GO:0009698) coumarin metabolic process(GO:0009804)
0.0	0.1	GO:0002507	tolerance induction(GO:0002507)
0.0	0.1	GO:0002331	pre-B cell allelic exclusion(GO:0002331)
0.0	0.0	GO:0002227	innate immune response in mucosa(GO:0002227) mucosal immune response(GO:0002385)
0.0	0.1	GO:0090382	phagolysosome assembly(GO:0001845) phagosome maturation(GO:0090382)
0.0	0.1	GO:0034616	response to laminar fluid shear stress(GO:0034616)
0.0	0.1	GO:0051489	regulation of filopodium assembly(GO:0051489)
0.0	0.0	GO:0016556	mRNA modification(GO:0016556)
0.0	0.1	GO:0003056	regulation of vascular smooth muscle contraction(GO:0003056)
0.0	0.1	GO:0000730	DNA recombinase assembly(GO:0000730) double-strand break repair via synthesis-dependent strand annealing(GO:0045003)
0.0	0.1	GO:0030644	cellular chloride ion homeostasis(GO:0030644) chloride ion homeostasis(GO:0055064)
0.0	0.1	GO:0007256	activation of JNKK activity(GO:0007256)
0.0	0.0	GO:0009151	purine deoxyribonucleotide metabolic process(GO:0009151)
0.0	0.2	GO:0007512	adult heart development(GO:0007512)
0.0	0.0	GO:0001831	trophectodermal cellular morphogenesis(GO:0001831)
0.0	0.1	GO:0043267	negative regulation of potassium ion transport(GO:0043267)
0.0	0.1	GO:0019228	neuronal action potential(GO:0019228)
0.0	0.1	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress(GO:0070059)
0.0	0.1	GO:0042989	sequestering of actin monomers(GO:0042989)
0.0	0.0	GO:0032776	DNA methylation on cytosine(GO:0032776) C-5 methylation of cytosine(GO:0090116)
0.0	0.0	GO:0052251	induction by organism of defense response of other organism involved in symbiotic interaction(GO:0052251)
0.0	0.1	GO:0090502	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000447) maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462) cleavage involved in rRNA processing(GO:0000469) endonucleolytic cleavage involved in rRNA processing(GO:0000478) endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000479) RNA phosphodiester bond hydrolysis, endonucleolytic(GO:0090502)
0.0	0.0	GO:0046642	negative regulation of alpha-beta T cell proliferation(GO:0046642)
0.0	0.1	GO:0072180	mesonephric duct morphogenesis(GO:0072180)
0.0	0.0	GO:0060159	regulation of dopamine receptor signaling pathway(GO:0060159)
0.0	0.1	GO:0034755	iron ion transmembrane transport(GO:0034755)
0.0	0.0	GO:0003161	cardiac conduction system development(GO:0003161)
0.0	0.0	GO:0043162	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.0	0.0	GO:0010903	negative regulation of very-low-density lipoprotein particle remodeling(GO:0010903)
0.0	0.1	GO:0006474	N-terminal protein amino acid acetylation(GO:0006474)
0.0	0.2	GO:0021904	dorsal/ventral neural tube patterning(GO:0021904)
0.0	0.0	GO:0045906	negative regulation of vasoconstriction(GO:0045906)
0.0	0.0	GO:0090400	stress-induced premature senescence(GO:0090400)
0.0	0.0	GO:0006924	activation-induced cell death of T cells(GO:0006924)
0.0	0.0	GO:0051132	NK T cell proliferation(GO:0001866) NK T cell activation(GO:0051132)
0.0	0.0	GO:0051573	negative regulation of histone H3-K9 methylation(GO:0051573)
0.0	0.1	GO:0051788	response to misfolded protein(GO:0051788)
0.0	0.1	GO:0030388	fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0	0.0	GO:0034201	response to oleic acid(GO:0034201)
0.0	0.1	GO:0002483	antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.0	0.0	GO:0001787	natural killer cell proliferation(GO:0001787)
0.0	0.0	GO:0070340	detection of bacterial lipoprotein(GO:0042494) detection of bacterial lipopeptide(GO:0070340)
0.0	0.0	GO:0002430	complement receptor mediated signaling pathway(GO:0002430)
0.0	0.1	GO:2000344	positive regulation of acrosome reaction(GO:2000344)
0.0	0.0	GO:0002495	antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.0	0.0	GO:0030889	negative regulation of B cell proliferation(GO:0030889)
0.0	0.2	GO:0060334	regulation of response to interferon-gamma(GO:0060330) regulation of interferon-gamma-mediated signaling pathway(GO:0060334)
0.0	0.1	GO:0045793	positive regulation of cell size(GO:0045793)
0.0	0.1	GO:0006491	N-glycan processing(GO:0006491)
0.0	0.3	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.0	0.0	GO:0048532	anatomical structure arrangement(GO:0048532)
0.0	0.1	GO:0048341	paraxial mesoderm formation(GO:0048341)
0.0	0.2	GO:0034199	activation of protein kinase A activity(GO:0034199)
0.0	0.0	GO:0010739	positive regulation of protein kinase A signaling(GO:0010739)
0.0	0.1	GO:0090659	adult walking behavior(GO:0007628) walking behavior(GO:0090659)
0.0	0.1	GO:0060158	phospholipase C-activating dopamine receptor signaling pathway(GO:0060158)
0.0	0.0	GO:0070682	proteasome regulatory particle assembly(GO:0070682)
0.0	0.1	GO:0071108	protein K48-linked deubiquitination(GO:0071108)
0.0	0.0	GO:0043457	regulation of cellular respiration(GO:0043457)
0.0	0.0	GO:0002328	pro-B cell differentiation(GO:0002328)
0.0	0.0	GO:0060261	positive regulation of transcription initiation from RNA polymerase II promoter(GO:0060261) positive regulation of DNA-templated transcription, initiation(GO:2000144)
0.0	0.1	GO:0002921	negative regulation of humoral immune response(GO:0002921)
0.0	0.1	GO:0008291	acetylcholine metabolic process(GO:0008291) acetate ester metabolic process(GO:1900619)
0.0	0.1	GO:0015840	urea transport(GO:0015840)
0.0	0.0	GO:0002093	auditory receptor cell morphogenesis(GO:0002093) auditory receptor cell stereocilium organization(GO:0060088)
0.0	0.0	GO:0015959	diadenosine polyphosphate metabolic process(GO:0015959)
0.0	0.0	GO:0019532	oxalate transport(GO:0019532)
0.0	0.2	GO:0042274	ribosomal small subunit biogenesis(GO:0042274)
0.0	0.0	GO:0071480	cellular response to gamma radiation(GO:0071480)
0.0	0.0	GO:0048289	isotype switching to IgE isotypes(GO:0048289) regulation of isotype switching to IgE isotypes(GO:0048293)
0.0	0.2	GO:0033209	tumor necrosis factor-mediated signaling pathway(GO:0033209)
0.0	0.0	GO:0072193	ureter smooth muscle development(GO:0072191) ureter smooth muscle cell differentiation(GO:0072193)
0.0	0.0	GO:0010560	positive regulation of glycoprotein biosynthetic process(GO:0010560) positive regulation of glycoprotein metabolic process(GO:1903020)
0.0	0.0	GO:0070120	ciliary neurotrophic factor-mediated signaling pathway(GO:0070120)
0.0	0.0	GO:0043653	mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.0	0.0	GO:0034695	response to prostaglandin E(GO:0034695)
0.0	0.1	GO:0070664	negative regulation of leukocyte proliferation(GO:0070664)
0.0	0.0	GO:0042996	regulation of Golgi to plasma membrane protein transport(GO:0042996)
0.0	0.0	GO:0007638	mechanosensory behavior(GO:0007638)
0.0	0.0	GO:0051790	short-chain fatty acid biosynthetic process(GO:0051790)
0.0	0.0	GO:0070777	D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0	0.0	GO:0034638	phosphatidylcholine catabolic process(GO:0034638)
0.0	0.4	GO:0050852	T cell receptor signaling pathway(GO:0050852)
0.0	0.0	GO:0015705	iodide transport(GO:0015705)
0.0	0.1	GO:0035434	copper ion transmembrane transport(GO:0035434)
0.0	0.0	GO:0060760	positive regulation of response to cytokine stimulus(GO:0060760)
0.0	0.1	GO:0031648	protein destabilization(GO:0031648)
0.0	0.0	GO:2001259	positive regulation of calcium ion transmembrane transporter activity(GO:1901021) positive regulation of cation channel activity(GO:2001259)
0.0	0.1	GO:0051085	chaperone mediated protein folding requiring cofactor(GO:0051085)
0.0	0.0	GO:0048643	positive regulation of skeletal muscle tissue development(GO:0048643)
0.0	0.0	GO:0035092	sperm chromatin condensation(GO:0035092)
0.0	0.0	GO:0014874	response to stimulus involved in regulation of muscle adaptation(GO:0014874)
0.0	0.0	GO:0010759	positive regulation of macrophage chemotaxis(GO:0010759)
0.0	0.0	GO:0071071	regulation of phospholipid biosynthetic process(GO:0071071) negative regulation of phospholipid biosynthetic process(GO:0071072)
0.0	0.1	GO:0032926	negative regulation of activin receptor signaling pathway(GO:0032926)
0.0	0.0	GO:0060287	epithelial cilium movement(GO:0003351) epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
0.0	0.2	GO:0016601	Rac protein signal transduction(GO:0016601)
0.0	0.0	GO:0043374	CD8-positive, alpha-beta T cell activation(GO:0036037) CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0	0.0	GO:0051533	NFAT protein import into nucleus(GO:0051531) regulation of NFAT protein import into nucleus(GO:0051532) positive regulation of NFAT protein import into nucleus(GO:0051533)
0.0	0.1	GO:0000303	response to superoxide(GO:0000303)
0.0	0.0	GO:0046501	protoporphyrinogen IX metabolic process(GO:0046501)
0.0	0.1	GO:0006895	Golgi to endosome transport(GO:0006895) Golgi to vacuole transport(GO:0006896)
0.0	0.0	GO:0006552	leucine catabolic process(GO:0006552)
0.0	0.0	GO:0000281	mitotic cytokinesis(GO:0000281)
0.0	0.1	GO:0007263	nitric oxide mediated signal transduction(GO:0007263)
0.0	0.0	GO:0070293	renal absorption(GO:0070293)
0.0	0.0	GO:0032070	regulation of deoxyribonuclease activity(GO:0032070)
0.0	0.0	GO:0010508	positive regulation of autophagy(GO:0010508)
0.0	0.0	GO:0046877	regulation of saliva secretion(GO:0046877)
0.0	0.1	GO:0034375	high-density lipoprotein particle remodeling(GO:0034375)
0.0	0.0	GO:0042118	endothelial cell activation(GO:0042118)
0.0	0.0	GO:0002691	regulation of cellular extravasation(GO:0002691)
0.0	0.2	GO:0016998	cell wall macromolecule catabolic process(GO:0016998)
0.0	0.0	GO:0071392	cellular response to estradiol stimulus(GO:0071392)
0.0	0.0	GO:0001661	conditioned taste aversion(GO:0001661)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0034993	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.1	0.2	GO:0042105	alpha-beta T cell receptor complex(GO:0042105)
0.0	0.1	GO:0031235	intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0	0.3	GO:0001891	phagocytic cup(GO:0001891)
0.0	0.5	GO:0005942	phosphatidylinositol 3-kinase complex(GO:0005942)
0.0	0.4	GO:0010494	cytoplasmic stress granule(GO:0010494)
0.0	0.1	GO:0000164	protein phosphatase type 1 complex(GO:0000164)
0.0	0.1	GO:0000942	condensed nuclear chromosome outer kinetochore(GO:0000942)
0.0	0.2	GO:0030315	T-tubule(GO:0030315)
0.0	0.1	GO:0030895	apolipoprotein B mRNA editing enzyme complex(GO:0030895)
0.0	0.1	GO:0072669	tRNA-splicing ligase complex(GO:0072669)
0.0	0.1	GO:0070022	transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0	0.1	GO:0071438	invadopodium membrane(GO:0071438)
0.0	0.2	GO:0042589	zymogen granule membrane(GO:0042589)
0.0	0.1	GO:0034451	centriolar satellite(GO:0034451)
0.0	0.3	GO:0016514	SWI/SNF complex(GO:0016514)
0.0	0.1	GO:0070775	H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0	0.1	GO:0030904	retromer complex(GO:0030904)
0.0	0.7	GO:0030173	integral component of Golgi membrane(GO:0030173)
0.0	0.1	GO:0001740	Barr body(GO:0001740)
0.0	0.2	GO:0001772	immunological synapse(GO:0001772)
0.0	0.5	GO:0005626	obsolete insoluble fraction(GO:0005626)
0.0	0.0	GO:0048179	activin receptor complex(GO:0048179)
0.0	0.1	GO:0034366	spherical high-density lipoprotein particle(GO:0034366)
0.0	0.1	GO:0030870	Mre11 complex(GO:0030870)
0.0	0.0	GO:0032777	Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0	0.1	GO:0005662	DNA replication factor A complex(GO:0005662)
0.0	0.0	GO:0031618	nuclear pericentric heterochromatin(GO:0031618)
0.0	0.1	GO:0035631	CD40 receptor complex(GO:0035631)
0.0	0.1	GO:0034362	low-density lipoprotein particle(GO:0034362)
0.0	0.1	GO:0031254	uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0	0.0	GO:0030891	VCB complex(GO:0030891)
0.0	0.1	GO:0005952	cAMP-dependent protein kinase complex(GO:0005952)
0.0	0.1	GO:0008250	oligosaccharyltransferase complex(GO:0008250)
0.0	0.0	GO:0001652	granular component(GO:0001652)
0.0	0.1	GO:0030877	beta-catenin destruction complex(GO:0030877)
0.0	0.0	GO:0005896	interleukin-6 receptor complex(GO:0005896)
0.0	0.2	GO:0005801	cis-Golgi network(GO:0005801)
0.0	0.1	GO:0031088	platelet dense granule membrane(GO:0031088)
0.0	0.4	GO:0030175	filopodium(GO:0030175)
0.0	0.0	GO:0071564	npBAF complex(GO:0071564)
0.0	0.1	GO:0030062	mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.0	0.1	GO:0030121	AP-1 adaptor complex(GO:0030121)
0.0	0.1	GO:0005577	fibrinogen complex(GO:0005577)
0.0	0.1	GO:0045179	apical cortex(GO:0045179)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.6	GO:0003836	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.1	0.5	GO:0030284	estrogen receptor activity(GO:0030284)
0.1	0.2	GO:0016309	1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.1	0.2	GO:0004591	oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.1	0.2	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.1	0.2	GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.1	0.2	GO:0004911	interleukin-2 receptor activity(GO:0004911)
0.1	0.2	GO:0047756	chondroitin 4-sulfotransferase activity(GO:0047756)
0.1	0.2	GO:0003726	double-stranded RNA adenosine deaminase activity(GO:0003726)
0.0	0.2	GO:0001609	G-protein coupled adenosine receptor activity(GO:0001609)
0.0	0.2	GO:0015925	galactosidase activity(GO:0015925)
0.0	0.1	GO:0035184	histone threonine kinase activity(GO:0035184)
0.0	0.1	GO:0033691	sialic acid binding(GO:0033691)
0.0	0.2	GO:0070053	thrombospondin receptor activity(GO:0070053)
0.0	0.2	GO:0016494	C-X-C chemokine receptor activity(GO:0016494)
0.0	0.4	GO:0016493	C-C chemokine receptor activity(GO:0016493)
0.0	0.3	GO:0030676	Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0	0.2	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.0	0.1	GO:0004117	calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117)
0.0	0.2	GO:0004563	beta-N-acetylhexosaminidase activity(GO:0004563)
0.0	0.1	GO:0008454	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0	0.3	GO:0005522	profilin binding(GO:0005522)
0.0	0.2	GO:0031013	troponin I binding(GO:0031013)
0.0	0.3	GO:0034593	phosphatidylinositol bisphosphate phosphatase activity(GO:0034593)
0.0	0.1	GO:0005025	transforming growth factor beta receptor activity, type I(GO:0005025)
0.0	0.2	GO:0051766	inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440) inositol trisphosphate kinase activity(GO:0051766)
0.0	0.7	GO:0045028	G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0	0.4	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0	0.1	GO:0043539	protein serine/threonine kinase activator activity(GO:0043539)
0.0	0.1	GO:0001637	G-protein coupled chemoattractant receptor activity(GO:0001637) chemokine receptor activity(GO:0004950)
0.0	0.0	GO:0001098	basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.0	0.1	GO:0004897	ciliary neurotrophic factor receptor activity(GO:0004897)
0.0	0.1	GO:0005131	growth hormone receptor binding(GO:0005131)
0.0	0.1	GO:0047238	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.0	1.2	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)
0.0	0.2	GO:0030507	spectrin binding(GO:0030507)
0.0	0.1	GO:0003909	DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.0	0.1	GO:0032454	histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0	0.1	GO:0005113	patched binding(GO:0005113)
0.0	0.1	GO:0003829	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0003829)
0.0	0.2	GO:0031435	mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0	0.1	GO:0005432	calcium:sodium antiporter activity(GO:0005432)
0.0	0.3	GO:0004697	protein kinase C activity(GO:0004697)
0.0	0.1	GO:0034452	dynactin binding(GO:0034452)
0.0	0.1	GO:0031628	opioid receptor binding(GO:0031628)
0.0	0.2	GO:0051879	Hsp90 protein binding(GO:0051879)
0.0	0.2	GO:0004691	cAMP-dependent protein kinase activity(GO:0004691)
0.0	0.1	GO:0047429	nucleoside-triphosphate diphosphatase activity(GO:0047429)
0.0	0.1	GO:0004476	mannose-6-phosphate isomerase activity(GO:0004476)
0.0	0.1	GO:0003691	double-stranded telomeric DNA binding(GO:0003691)
0.0	0.2	GO:0005031	tumor necrosis factor-activated receptor activity(GO:0005031)
0.0	0.1	GO:0004528	phosphodiesterase I activity(GO:0004528)
0.0	0.1	GO:0008174	mRNA methyltransferase activity(GO:0008174)
0.0	0.1	GO:0003987	acetate-CoA ligase activity(GO:0003987)
0.0	0.0	GO:0016361	activin receptor activity, type I(GO:0016361)
0.0	0.0	GO:0042608	T cell receptor binding(GO:0042608)
0.0	0.1	GO:0043734	DNA demethylase activity(GO:0035514) DNA-N1-methyladenine dioxygenase activity(GO:0043734)
0.0	0.1	GO:0046404	ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734)
0.0	0.1	GO:0016778	diphosphotransferase activity(GO:0016778)
0.0	0.1	GO:0004332	fructose-bisphosphate aldolase activity(GO:0004332)
0.0	0.1	GO:0016286	small conductance calcium-activated potassium channel activity(GO:0016286)
0.0	0.1	GO:0050431	transforming growth factor beta binding(GO:0050431)
0.0	0.1	GO:0070087	chromo shadow domain binding(GO:0070087)
0.0	0.0	GO:0015193	L-proline transmembrane transporter activity(GO:0015193)
0.0	0.0	GO:0030023	extracellular matrix constituent conferring elasticity(GO:0030023) structural molecule activity conferring elasticity(GO:0097493)
0.0	0.1	GO:0003886	DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0	0.3	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0	0.0	GO:0015204	urea transmembrane transporter activity(GO:0015204)
0.0	0.1	GO:0005521	lamin binding(GO:0005521)
0.0	0.0	GO:0043175	RNA polymerase core enzyme binding(GO:0043175)
0.0	0.0	GO:0070653	high-density lipoprotein particle receptor binding(GO:0070653)
0.0	0.3	GO:0005164	tumor necrosis factor receptor binding(GO:0005164)
0.0	0.1	GO:0005375	copper ion transmembrane transporter activity(GO:0005375)
0.0	0.0	GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.0	0.2	GO:0005416	cation:amino acid symporter activity(GO:0005416)
0.0	0.1	GO:0030346	protein phosphatase 2B binding(GO:0030346)
0.0	0.1	GO:0005381	iron ion transmembrane transporter activity(GO:0005381)
0.0	0.2	GO:0005251	delayed rectifier potassium channel activity(GO:0005251)
0.0	0.1	GO:0052650	NADP-retinol dehydrogenase activity(GO:0052650)
0.0	0.1	GO:0099604	calcium-release channel activity(GO:0015278) ligand-gated calcium channel activity(GO:0099604)
0.0	0.0	GO:0008559	xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.0	0.1	GO:0034713	type I transforming growth factor beta receptor binding(GO:0034713)
0.0	0.1	GO:0008079	translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.0	0.0	GO:0030292	protein tyrosine kinase inhibitor activity(GO:0030292)
0.0	0.1	GO:0008568	microtubule-severing ATPase activity(GO:0008568)
0.0	0.0	GO:0008545	JUN kinase kinase activity(GO:0008545)
0.0	0.0	GO:0047631	ADP-ribose diphosphatase activity(GO:0047631)
0.0	0.0	GO:0008179	adenylate cyclase binding(GO:0008179)
0.0	0.0	GO:0004949	cannabinoid receptor activity(GO:0004949)
0.0	0.0	GO:0031685	adenosine receptor binding(GO:0031685)
0.0	0.1	GO:0003796	lysozyme activity(GO:0003796)
0.0	0.0	GO:0015038	glutathione disulfide oxidoreductase activity(GO:0015038)
0.0	0.4	GO:0003823	antigen binding(GO:0003823)
0.0	0.0	GO:0031177	phosphopantetheine binding(GO:0031177)
0.0	0.1	GO:0001727	lipid kinase activity(GO:0001727)
0.0	0.0	GO:0004844	uracil DNA N-glycosylase activity(GO:0004844) deaminated base DNA N-glycosylase activity(GO:0097506)
0.0	0.1	GO:0004046	aminoacylase activity(GO:0004046)
0.0	0.1	GO:0005499	vitamin D binding(GO:0005499)
0.0	0.0	GO:0034056	estrogen response element binding(GO:0034056)
0.0	0.0	GO:0017159	pantetheine hydrolase activity(GO:0017159)
0.0	0.1	GO:0008379	thioredoxin peroxidase activity(GO:0008379)
0.0	0.0	GO:0004566	beta-glucuronidase activity(GO:0004566)
0.0	0.1	GO:0048156	tau protein binding(GO:0048156)
0.0	0.1	GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0	0.1	GO:0050700	CARD domain binding(GO:0050700)
0.0	0.0	GO:0004775	succinate-CoA ligase (ADP-forming) activity(GO:0004775)
0.0	0.3	GO:0016831	carboxy-lyase activity(GO:0016831)
0.0	0.2	GO:0030159	receptor signaling complex scaffold activity(GO:0030159)
0.0	0.0	GO:0046790	virion binding(GO:0046790)
0.0	0.0	GO:0000832	inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832)
0.0	0.1	GO:0008239	dipeptidyl-peptidase activity(GO:0008239)
0.0	0.0	GO:0008332	low voltage-gated calcium channel activity(GO:0008332)
0.0	0.0	GO:0031014	troponin T binding(GO:0031014)
0.0	0.1	GO:0004126	cytidine deaminase activity(GO:0004126)
0.0	0.0	GO:0004865	protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.0	0.0	GO:0004792	thiosulfate sulfurtransferase activity(GO:0004792)
0.0	0.0	GO:0004517	nitric-oxide synthase activity(GO:0004517)
0.0	0.0	GO:0019531	oxalate transmembrane transporter activity(GO:0019531)
0.0	0.1	GO:0030274	LIM domain binding(GO:0030274)
0.0	0.0	GO:0004706	JUN kinase kinase kinase activity(GO:0004706)
0.0	0.0	GO:0004500	dopamine beta-monooxygenase activity(GO:0004500)
0.0	0.2	GO:0005086	ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0	0.1	GO:0004028	3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.0	0.0	GO:0005176	ErbB-2 class receptor binding(GO:0005176)
0.0	0.1	GO:0070569	uridylyltransferase activity(GO:0070569)
0.0	0.0	GO:0005049	nuclear export signal receptor activity(GO:0005049)
0.0	0.3	GO:0003950	NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0	0.0	GO:0004999	vasoactive intestinal polypeptide receptor activity(GO:0004999)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.7	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
2.2	PID CD8 TCR PATHWAY	TCR signaling in naïve CD8+ T cells
0.4	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.2	ST PAC1 RECEPTOR PATHWAY	PAC1 Receptor Pathway
0.1	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
1.3	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1	PID IL5 PATHWAY	IL5-mediated signaling events
0.6	PID GMCSF PATHWAY	GMCSF-mediated signaling events
0.1	PID ERBB4 PATHWAY	ErbB4 signaling events
0.5	PID IL8 CXCR2 PATHWAY	IL8- and CXCR2-mediated signaling events
0.5	PID ERBB1 INTERNALIZATION PATHWAY	Internalization of ErbB1
0.1	PID FAS PATHWAY	FAS (CD95) signaling pathway
0.1	PID S1P S1P4 PATHWAY	S1P4 pathway
0.1	ST IL 13 PATHWAY	Interleukin 13 (IL-13) Pathway
0.4	PID TXA2PATHWAY	Thromboxane A2 receptor signaling
0.1	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
0.2	PID CERAMIDE PATHWAY	Ceramide signaling pathway
0.1	PID ERBB1 RECEPTOR PROXIMAL PATHWAY	EGF receptor (ErbB1) signaling pathway
0.1	SA B CELL RECEPTOR COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0	PID NFKAPPAB ATYPICAL PATHWAY	Atypical NF-kappaB pathway
0.1	PID S1P S1P3 PATHWAY	S1P3 pathway
0.1	PID S1P META PATHWAY	Sphingosine 1-phosphate (S1P) pathway
0.4	PID ANGIOPOIETIN RECEPTOR PATHWAY	Angiopoietin receptor Tie2-mediated signaling
0.3	PID FCER1 PATHWAY	Fc-epsilon receptor I signaling in mast cells
0.2	PID IL2 1PATHWAY	IL2-mediated signaling events
0.0	PID ECADHERIN KERATINOCYTE PATHWAY	E-cadherin signaling in keratinocytes
0.3	PID CDC42 REG PATHWAY	Regulation of CDC42 activity
0.7	PID BETA CATENIN NUC PATHWAY	Regulation of nuclear beta catenin signaling and target gene transcription

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.6	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.1	0.6	REACTOME CD28 DEPENDENT VAV1 PATHWAY	Genes involved in CD28 dependent Vav1 pathway
0.1	0.2	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.0	0.6	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0	0.4	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
0.0	0.6	REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS	Genes involved in Termination of O-glycan biosynthesis
0.0	0.2	REACTOME PROSTANOID LIGAND RECEPTORS	Genes involved in Prostanoid ligand receptors
0.0	0.2	REACTOME SPRY REGULATION OF FGF SIGNALING	Genes involved in Spry regulation of FGF signaling
0.0	0.1	REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION	Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0	0.3	REACTOME HYALURONAN UPTAKE AND DEGRADATION	Genes involved in Hyaluronan uptake and degradation
0.0	0.2	REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION	Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.0	0.3	REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0	0.1	REACTOME GPVI MEDIATED ACTIVATION CASCADE	Genes involved in GPVI-mediated activation cascade
0.0	0.2	REACTOME CTLA4 INHIBITORY SIGNALING	Genes involved in CTLA4 inhibitory signaling
0.0	0.4	REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0	0.5	REACTOME IL RECEPTOR SHC SIGNALING	Genes involved in Interleukin receptor SHC signaling
0.0	0.2	REACTOME IL 2 SIGNALING	Genes involved in Interleukin-2 signaling
0.0	0.5	REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0	0.2	REACTOME P38MAPK EVENTS	Genes involved in p38MAPK events
0.0	0.4	REACTOME EFFECTS OF PIP2 HYDROLYSIS	Genes involved in Effects of PIP2 hydrolysis
0.0	0.4	REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE	Genes involved in Synthesis of PIPs at the plasma membrane
0.0	0.3	REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS	Genes involved in Nucleotide-like (purinergic) receptors
0.0	0.4	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.0	0.1	REACTOME REGULATION OF SIGNALING BY CBL	Genes involved in Regulation of signaling by CBL
0.0	0.1	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
0.0	0.2	REACTOME N GLYCAN ANTENNAE ELONGATION	Genes involved in N-Glycan antennae elongation
0.0	0.4	REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE	Genes involved in Nitric oxide stimulates guanylate cyclase
0.0	0.6	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
0.0	0.2	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.0	0.0	REACTOME APC CDC20 MEDIATED DEGRADATION OF NEK2A	Genes involved in APC-Cdc20 mediated degradation of Nek2A
0.0	0.1	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.0	0.1	REACTOME INTEGRATION OF PROVIRUS	Genes involved in Integration of provirus
0.0	0.2	REACTOME COSTIMULATION BY THE CD28 FAMILY	Genes involved in Costimulation by the CD28 family
0.0	0.1	REACTOME ADP SIGNALLING THROUGH P2RY1	Genes involved in ADP signalling through P2Y purinoceptor 1
0.0	0.2	REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	Genes involved in Regulation of gene expression in beta cells
0.0	0.3	REACTOME POST NMDA RECEPTOR ACTIVATION EVENTS	Genes involved in Post NMDA receptor activation events
0.0	0.1	REACTOME TIE2 SIGNALING	Genes involved in Tie2 Signaling
0.0	0.0	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
0.0	0.2	REACTOME CITRIC ACID CYCLE TCA CYCLE	Genes involved in Citric acid cycle (TCA cycle)
0.0	0.0	REACTOME ABORTIVE ELONGATION OF HIV1 TRANSCRIPT IN THE ABSENCE OF TAT	Genes involved in Abortive elongation of HIV-1 transcript in the absence of Tat
0.0	0.0	REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION	Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.0	0.0	REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1	Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.0	0.1	REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY	Genes involved in Adenylate cyclase activating pathway
0.0	0.1	REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP	Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)