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ENCODE: H3K4me1 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for NFATC1

Z-value: 1.61

Motif logo

Transcription factors associated with NFATC1

Gene Symbol	Gene ID	Gene Info
NFATC1 Ensembl NCBI GeneCards UniProt	ENSG00000131196.13	NFATC1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
NFATC1	chr18_77159160_77159516	984	0.631431	-0.94	1.3e-04	Click!
NFATC1	chr18_77164936_77165190	4671	0.275487	-0.88	1.6e-03	Click!
NFATC1	chr18_77166940_77167091	6623	0.257756	-0.86	3.0e-03	Click!
NFATC1	chr18_77154994_77155234	742	0.728425	-0.84	4.9e-03	Click!
NFATC1	chr18_77165231_77165672	5059	0.270449	-0.84	5.1e-03	Click!

Activity of the NFATC1 motif across conditions

Conditions sorted by the z-value of the NFATC1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr21_35902480_35902631	0.54	RCAN1	regulator of calcineurin 1	3294	0.26
chr9_127104782_127105372	0.46	ENSG00000264237	.	7733	0.2
chr5_55164394_55164545	0.44	IL31RA	interleukin 31 receptor A	15111	0.19
chr10_114863343_114863771	0.44	TCF7L2	transcription factor 7-like 2 (T-cell specific, HMG-box)	40122	0.21
chr11_121501091_121501242	0.43	SORL1	sortilin-related receptor, L(DLR class) A repeats containing	40038	0.22
chr20_10055682_10055833	0.41	ENSG00000264599	.	18789	0.2
chr1_6301763_6302398	0.41	HES3	hes family bHLH transcription factor 3	2172	0.18
chr21_17944689_17944974	0.40	ENSG00000207863	.	17726	0.2
chr5_179246518_179247261	0.37	SQSTM1	sequestosome 1	870	0.42
chr6_132511743_132511894	0.37	ENSG00000265669	.	75415	0.11
chr11_61690283_61690510	0.37	RAB3IL1	RAB3A interacting protein (rabin3)-like 1	2655	0.18
chr14_69388884_69389440	0.37	ACTN1	actinin, alpha 1	25103	0.2
chr11_19627998_19628149	0.36	ENSG00000207407	.	15235	0.2
chr8_141364670_141364821	0.36	TRAPPC9	trafficking protein particle complex 9	96284	0.08
chr7_137353876_137354027	0.36	DGKI	diacylglycerol kinase, iota	177331	0.03
chr7_151182024_151182303	0.36	ENSG00000241959	.	20139	0.13
chr15_33148725_33148876	0.35	FMN1	formin 1	31655	0.17
chr2_47416519_47416670	0.35	CALM2	calmodulin 2 (phosphorylase kinase, delta)	12854	0.21
chr11_35448443_35448594	0.35	SLC1A2	solute carrier family 1 (glial high affinity glutamate transporter), member 2	6908	0.22
chr6_82317027_82317178	0.35	ENSG00000212336	.	14815	0.23
chr6_56555787_56555938	0.35	DST	dystonin	48068	0.18
chr1_219616434_219616585	0.35	ENSG00000252240	.	220210	0.02
chr2_216523684_216523835	0.35	ENSG00000212055	.	219883	0.02
chr16_15533494_15533711	0.35	C16orf45	chromosome 16 open reading frame 45	5270	0.21
chr9_4303266_4303417	0.35	GLIS3	GLIS family zinc finger 3	3425	0.25
chr6_148589578_148589729	0.35	SASH1	SAM and SH3 domain containing 1	3787	0.25
chr6_128390231_128390382	0.34	PTPRK	protein tyrosine phosphatase, receptor type, K	4398	0.3
chr4_71532339_71532558	0.34	IGJ	immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides	71	0.96
chr7_116804373_116804524	0.34	ST7-AS2	ST7 antisense RNA 2	17914	0.23
chr1_78721233_78721384	0.34	ENSG00000237413	.	26002	0.2
chr4_157888355_157888628	0.33	PDGFC	platelet derived growth factor C	3564	0.27
chr12_63155045_63155196	0.33	ENSG00000200296	.	89561	0.08
chr11_11995194_11995345	0.33	DKK3	dickkopf WNT signaling pathway inhibitor 3	34861	0.21
chr8_108518687_108518838	0.33	ANGPT1	angiopoietin 1	8479	0.33
chr3_149833178_149833329	0.33	RP11-167H9.4		17434	0.21
chr6_128529618_128529908	0.33	PTPRK	protein tyrosine phosphatase, receptor type, K	113563	0.07
chr18_52920557_52920708	0.33	TCF4	transcription factor 4	22270	0.26
chr4_114304726_114304877	0.32	ANK2	ankyrin 2, neuronal	10286	0.22
chr8_32530949_32531215	0.32	NRG1	neuregulin 1	25725	0.27
chr13_24617983_24618134	0.32	SPATA13	spermatogenesis associated 13	64114	0.11
chr4_186578170_186578442	0.32	SORBS2	sorbin and SH3 domain containing 2	183	0.95
chr8_120615500_120615651	0.32	ENPP2	ectonucleotide pyrophosphatase/phosphodiesterase 2	10327	0.27
chr5_15249746_15249921	0.32	ENSG00000202269	.	138804	0.05
chr4_79487146_79487361	0.32	ANXA3	annexin A3	12179	0.24
chr2_69518306_69518457	0.32	ENSG00000252250	.	43351	0.15
chr13_75942001_75942152	0.32	TBC1D4-AS1	TBC1D4 antisense RNA 1	9354	0.24
chr6_116685228_116685657	0.31	DSE	dermatan sulfate epimerase	5568	0.22
chr13_74792422_74792795	0.31	ENSG00000206617	.	70743	0.12
chr11_121963341_121963492	0.31	ENSG00000207971	.	7136	0.17
chr2_177392067_177392218	0.31	ENSG00000252027	.	137262	0.04
chr5_43781026_43781177	0.31	NNT	nicotinamide nucleotide transhydrogenase	135642	0.05
chr14_100240950_100241315	0.31	EML1	echinoderm microtubule associated protein like 1	1091	0.59
chr9_79075654_79076239	0.31	GCNT1	glucosaminyl (N-acetyl) transferase 1, core 2	1800	0.46
chr22_28625991_28626142	0.31	ENSG00000201209	.	2745	0.37
chr5_54157834_54157985	0.31	ENSG00000221073	.	9133	0.26
chr14_72142038_72142189	0.31	SIPA1L1	signal-induced proliferation-associated 1 like 1	56640	0.17
chr6_132301065_132301216	0.30	CTGF	connective tissue growth factor	28627	0.18
chr6_72121829_72121980	0.30	ENSG00000207827	.	8580	0.23
chr16_55520614_55520898	0.30	MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	1818	0.4
chr1_96831244_96831395	0.30	ENSG00000200800	.	139862	0.05
chr9_103340467_103340618	0.30	MURC	muscle-related coiled-coil protein	181	0.95
chr12_26430442_26430909	0.30	RP11-283G6.5		5822	0.22
chr3_105510379_105510530	0.30	CBLB	Cbl proto-oncogene B, E3 ubiquitin protein ligase	77433	0.13
chr1_214647384_214647535	0.30	PTPN14	protein tyrosine phosphatase, non-receptor type 14	9313	0.29
chr11_112112150_112112301	0.30	ENSG00000215954	.	6328	0.12
chr11_77313091_77313242	0.30	ENSG00000271767	.	6942	0.16
chr3_124827683_124827880	0.30	ENSG00000199327	.	10263	0.17
chr6_143670247_143670398	0.29	AL031320.1		89253	0.07
chr9_21656575_21656726	0.29	ENSG00000244230	.	42663	0.15
chr11_102009263_102009414	0.29	YAP1	Yes-associated protein 1	26093	0.15
chr2_223920021_223920251	0.29	KCNE4	potassium voltage-gated channel, Isk-related family, member 4	3274	0.35
chr10_19026308_19026459	0.29	ARL5B	ADP-ribosylation factor-like 5B	78049	0.1
chr20_6685250_6685401	0.29	BMP2	bone morphogenetic protein 2	62986	0.15
chr2_9517769_9518003	0.29	ITGB1BP1	integrin beta 1 binding protein 1	42537	0.15
chr12_107368695_107368994	0.29	C12orf23	chromosome 12 open reading frame 23	8131	0.17
chr4_77725622_77725773	0.29	RP11-359D14.3		2580	0.3
chr18_56247923_56248074	0.29	ENSG00000252284	.	19865	0.14
chr8_21766211_21767399	0.29	DOK2	docking protein 2, 56kDa	4369	0.22
chr5_71747550_71747979	0.29	RP11-389C8.2		9550	0.25
chr8_131245327_131245615	0.29	ASAP1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	13817	0.26
chr9_18479738_18479998	0.29	ADAMTSL1	ADAMTS-like 1	5637	0.32
chr9_113639802_113639953	0.29	ENSG00000206923	.	25740	0.21
chr15_101711256_101711683	0.29	CHSY1	chondroitin sulfate synthase 1	80668	0.08
chr10_17220959_17221110	0.28	TRDMT1	tRNA aspartic acid methyltransferase 1	4375	0.22
chr5_158173853_158174004	0.28	CTD-2363C16.1		236086	0.02
chr5_149519603_149519837	0.28	PDGFRB	platelet-derived growth factor receptor, beta polypeptide	2720	0.21
chr2_109857650_109857801	0.28	ENSG00000265965	.	72356	0.11
chr5_39524488_39524639	0.28	DAB2	Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)	62161	0.15
chr14_51228839_51228990	0.28	NIN	ninein (GSK3B interacting protein)	4599	0.2
chr3_132324789_132324940	0.28	ACKR4	atypical chemokine receptor 4	8783	0.22
chr2_100591017_100591168	0.28	AFF3	AF4/FMR2 family, member 3	129900	0.05
chr11_73990200_73990857	0.28	ENSG00000206913	.	26931	0.14
chr22_40705760_40705911	0.28	ADSL	adenylosuccinate lyase	36672	0.14
chr18_32382440_32382591	0.28	DTNA	dystrobrevin, alpha	15411	0.2
chr1_175946929_175947183	0.28	ENSG00000252906	.	9380	0.26
chr4_40889441_40889724	0.28	APBB2	amyloid beta (A4) precursor protein-binding, family B, member 2	2860	0.27
chr4_54717943_54718094	0.28	RP11-89B16.1		48020	0.17
chr5_64487632_64487783	0.28	ENSG00000207439	.	68511	0.14
chr1_173310923_173311074	0.28	ENSG00000251817	.	60782	0.13
chr8_49431262_49431413	0.28	RP11-770E5.1		32790	0.24
chr8_8537594_8537745	0.28	CLDN23	claudin 23	21779	0.21
chr1_56181953_56182104	0.28	PIGQP1	phosphatidylinositol glycan anchor biosynthesis, class Q pseudogene 1	222925	0.02
chr6_107978488_107978941	0.28	SCML4	sex comb on midleg-like 4 (Drosophila)	74885	0.11
chr10_15528350_15528501	0.28	FAM171A1	family with sequence similarity 171, member A1	115364	0.07
chrX_13269027_13269605	0.28	GS1-600G8.3		59455	0.14
chr7_137521422_137521598	0.28	DGKI	diacylglycerol kinase, iota	9772	0.27
chr10_657520_657671	0.28	RP11-809C18.3		16983	0.15
chr9_97703502_97703653	0.28	RP11-54O15.3		6349	0.2
chr6_19698381_19698532	0.28	ENSG00000200957	.	55696	0.16
chr11_95838965_95839116	0.28	MTMR2	myotubularin related protein 2	181581	0.03
chr2_36666145_36666296	0.28	CRIM1	cysteine rich transmembrane BMP regulator 1 (chordin-like)	74613	0.1
chr17_25642061_25642212	0.27	WSB1	WD repeat and SOCS box containing 1	20764	0.2
chr11_123059894_123060045	0.27	CTD-2216M2.1		459	0.83
chr3_148898157_148898308	0.27	CP	ceruloplasmin (ferroxidase)	824	0.65
chr7_13782821_13782972	0.27	ETV1	ets variant 1	243170	0.02
chr17_32580574_32580862	0.27	CCL2	chemokine (C-C motif) ligand 2	1586	0.24
chr22_47426182_47426436	0.27	ENSG00000221672	.	182506	0.03
chr7_15841281_15841432	0.27	MEOX2	mesenchyme homeobox 2	114919	0.07
chr7_90346858_90347009	0.27	CDK14	cyclin-dependent kinase 14	7757	0.3
chr3_55191596_55191747	0.27	LRTM1	leucine-rich repeats and transmembrane domains 1	190556	0.03
chr2_120996591_120996972	0.27	RALB	v-ral simian leukemia viral oncogene homolog B	859	0.59
chr5_76463438_76463589	0.27	ZBED3-AS1	ZBED3 antisense RNA 1	28439	0.15
chr5_169134550_169134701	0.27	DOCK2	dedicator of cytokinesis 2	3672	0.33
chr10_74496065_74496270	0.27	ENSG00000266719	.	15380	0.16
chr2_237928848_237928999	0.27	ENSG00000202341	.	4975	0.25
chr13_76359048_76359199	0.27	LMO7	LIM domain 7	3851	0.31
chr13_32914724_32915103	0.27	BRCA2	breast cancer 2, early onset	25271	0.15
chr12_26150271_26150549	0.27	RASSF8	Ras association (RalGDS/AF-6) domain family (N-terminal) member 8	2473	0.34
chr6_100715988_100716139	0.27	RP1-121G13.2		158931	0.04
chr11_94526714_94526894	0.27	AMOTL1	angiomotin like 1	25267	0.2
chr16_87891158_87892093	0.27	SLC7A5	solute carrier family 7 (amino acid transporter light chain, L system), member 5	5620	0.19
chr22_47149537_47150247	0.27	CTA-29F11.1		8568	0.18
chr2_161232105_161232912	0.27	ENSG00000252465	.	20971	0.19
chr5_71441214_71441365	0.27	ENSG00000264099	.	24005	0.21
chr15_45381136_45381287	0.27	RP11-109D20.2		14965	0.09
chr2_151412177_151412328	0.27	RND3	Rho family GTPase 3	16727	0.31
chr7_1499695_1500152	0.27	AC102953.4		350	0.72
chr4_150087781_150087932	0.26	ENSG00000239168	.	175071	0.04
chr10_60838878_60839029	0.26	PHYHIPL	phytanoyl-CoA 2-hydroxylase interacting protein-like	97397	0.09
chr2_158029538_158029689	0.26	GALNT5	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)	84497	0.1
chr2_191910102_191910403	0.26	ENSG00000231858	.	24000	0.15
chr5_39419337_39419488	0.26	DAB2	Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)	5558	0.3
chr7_93954349_93954500	0.26	COL1A2	collagen, type I, alpha 2	69449	0.13
chr4_7905515_7905666	0.26	AFAP1	actin filament associated protein 1	31550	0.17
chr1_78769110_78769410	0.26	PTGFR	prostaglandin F receptor (FP)	308	0.93
chr8_131244504_131244746	0.26	ASAP1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	14663	0.26
chr12_115372372_115372523	0.26	ENSG00000252459	.	196938	0.03
chr3_124764370_124764521	0.26	HEG1	heart development protein with EGF-like domains 1	10357	0.19
chr16_20891936_20892087	0.26	DCUN1D3	DCN1, defective in cullin neddylation 1, domain containing 3	11709	0.15
chr2_85484950_85485101	0.26	ENSG00000221579	.	41132	0.09
chr17_41016311_41016609	0.26	AOC4P	amine oxidase, copper containing 4, pseudogene	2836	0.12
chr1_235053615_235054079	0.26	ENSG00000239690	.	13914	0.26
chr1_66267521_66267672	0.26	PDE4B	phosphodiesterase 4B, cAMP-specific	8732	0.26
chr18_21110127_21110312	0.26	NPC1	Niemann-Pick disease, type C1	3185	0.23
chr2_208121057_208121376	0.26	AC007879.5		2240	0.34
chr15_100051927_100052783	0.26	AC015660.1	HCG1993240; Serologically defined breast cancer antigen NY-BR-40; Uncharacterized protein	13777	0.21
chr9_73204265_73204416	0.26	ENSG00000272232	.	9963	0.28
chr16_9212818_9212969	0.26	RP11-473I1.10		11795	0.16
chr16_84858002_84858153	0.26	RP11-254F19.2		3792	0.21
chr16_66150653_66150937	0.26	ENSG00000201999	.	184917	0.03
chr2_45581409_45581560	0.26	SRBD1	S1 RNA binding domain 1	213670	0.02
chr1_236827406_236827557	0.26	ACTN2	actinin, alpha 2	22273	0.21
chr1_179322658_179322809	0.26	ENSG00000263633	.	10715	0.19
chr7_100067086_100067551	0.26	TSC22D4	TSC22 domain family, member 4	1619	0.17
chr1_26113882_26114033	0.26	SEPN1	selenoprotein N, 1	12710	0.11
chr22_43000472_43000822	0.26	POLDIP3	polymerase (DNA-directed), delta interacting protein 3	1675	0.23
chr5_138164777_138164928	0.25	CTNNA1	catenin (cadherin-associated protein), alpha 1, 102kDa	44875	0.12
chr8_121275153_121275304	0.25	COL14A1	collagen, type XIV, alpha 1	66073	0.14
chr2_218723877_218724028	0.25	TNS1	tensin 1	17069	0.25
chr5_79887117_79887268	0.25	ANKRD34B	ankyrin repeat domain 34B	20885	0.16
chr1_85809222_85809373	0.25	ENSG00000264380	.	59004	0.09
chr2_163053003_163053154	0.25	AC007750.5		36750	0.15
chr5_111084347_111084498	0.25	NREP	neuronal regeneration related protein	7526	0.21
chr11_130272299_130272590	0.25	ADAMTS8	ADAM metallopeptidase with thrombospondin type 1 motif, 8	26444	0.2
chr4_72061057_72061208	0.25	SLC4A4	solute carrier family 4 (sodium bicarbonate cotransporter), member 4	8088	0.31
chr13_30426801_30426952	0.25	UBL3	ubiquitin-like 3	2055	0.46
chr6_85257015_85257166	0.25	RP11-132M7.3		142053	0.05
chr6_75853592_75853743	0.25	COL12A1	collagen, type XII, alpha 1	8238	0.28
chr15_32815666_32815817	0.25	AC135983.2	Protein LOC100996413	40919	0.1
chr8_119757469_119757620	0.25	SAMD12	sterile alpha motif domain containing 12	123310	0.06
chr3_73119570_73119721	0.25	PPP4R2	protein phosphatase 4, regulatory subunit 2	6480	0.15
chr12_65926260_65926711	0.25	MSRB3	methionine sulfoxide reductase B3	205830	0.02
chr12_116966140_116966291	0.25	MAP1LC3B2	microtubule-associated protein 1 light chain 3 beta 2	30971	0.22
chr3_196870510_196870661	0.25	DLG1	discs, large homolog 1 (Drosophila)	39920	0.16
chr3_177186614_177186765	0.25	ENSG00000252028	.	34651	0.24
chr13_45478155_45478306	0.25	NUFIP1	nuclear fragile X mental retardation protein interacting protein 1	85388	0.08
chr1_100056261_100056412	0.25	PALMD	palmdelphin	55163	0.15
chr4_26022444_26022595	0.25	SMIM20	small integral membrane protein 20	106588	0.07
chr3_187989530_187989681	0.25	LPP	LIM domain containing preferred translocation partner in lipoma	31953	0.22
chr6_131360559_131360710	0.25	EPB41L2	erythrocyte membrane protein band 4.1-like 2	23082	0.26
chr16_70736623_70736774	0.25	VAC14	Vac14 homolog (S. cerevisiae)	2550	0.22
chr3_72537234_72537495	0.25	RYBP	RING1 and YY1 binding protein	41295	0.18
chr6_125583374_125583525	0.25	HDDC2	HD domain containing 2	39634	0.18
chr15_48995639_48995790	0.25	FBN1	fibrillin 1	57668	0.12
chr15_69596184_69596335	0.25	PAQR5	progestin and adipoQ receptor family member V	4968	0.14
chr15_67289212_67289363	0.25	SMAD3	SMAD family member 3	66814	0.13
chr11_76050281_76050680	0.25	PRKRIR	protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor)	41506	0.11
chr17_59295493_59295787	0.25	RP11-136H19.1		82315	0.08
chr10_89300723_89300874	0.25	ENSG00000222192	.	22145	0.19
chr11_118789955_118791011	0.24	BCL9L	B-cell CLL/lymphoma 9-like	870	0.37

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of NFATC1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.5	GO:0060666	dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.1	0.6	GO:0007171	activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.1	0.1	GO:0060028	convergent extension involved in axis elongation(GO:0060028)
0.1	0.5	GO:0060997	dendritic spine morphogenesis(GO:0060997) regulation of dendritic spine morphogenesis(GO:0061001) dendritic spine organization(GO:0097061)
0.1	0.1	GO:0043438	acetoacetic acid metabolic process(GO:0043438)
0.1	0.1	GO:0010837	regulation of keratinocyte proliferation(GO:0010837)
0.1	0.3	GO:0043589	skin morphogenesis(GO:0043589)
0.1	0.3	GO:0043129	surfactant homeostasis(GO:0043129) chemical homeostasis within a tissue(GO:0048875)
0.1	0.2	GO:0032467	positive regulation of cytokinesis(GO:0032467)
0.1	0.2	GO:0071692	sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.1	0.1	GO:0072677	eosinophil chemotaxis(GO:0048245) eosinophil migration(GO:0072677)
0.1	0.2	GO:0006931	substrate-dependent cell migration, cell attachment to substrate(GO:0006931)
0.1	0.2	GO:0030538	embryonic genitalia morphogenesis(GO:0030538)
0.1	0.1	GO:0061526	acetylcholine secretion, neurotransmission(GO:0014055) regulation of acetylcholine secretion, neurotransmission(GO:0014056) acetylcholine secretion(GO:0061526)
0.1	0.2	GO:0070141	response to UV-A(GO:0070141)
0.1	0.1	GO:0007221	positive regulation of transcription of Notch receptor target(GO:0007221)
0.1	0.2	GO:0060083	smooth muscle contraction involved in micturition(GO:0060083)
0.1	0.5	GO:0007567	parturition(GO:0007567)
0.1	0.2	GO:0034629	cellular protein complex localization(GO:0034629)
0.1	0.1	GO:0060129	thyroid-stimulating hormone-secreting cell differentiation(GO:0060129)
0.1	0.2	GO:0007132	meiotic metaphase I(GO:0007132)
0.0	0.1	GO:0032353	negative regulation of hormone metabolic process(GO:0032351) negative regulation of hormone biosynthetic process(GO:0032353)
0.0	0.1	GO:0034638	phosphatidylcholine catabolic process(GO:0034638)
0.0	0.2	GO:0015014	heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.0	0.1	GO:0051284	negative regulation of release of sequestered calcium ion into cytosol(GO:0051280) positive regulation of sequestering of calcium ion(GO:0051284) negative regulation of calcium ion transmembrane transport(GO:1903170)
0.0	0.1	GO:0019800	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0	0.2	GO:0008218	bioluminescence(GO:0008218)
0.0	0.0	GO:0032344	regulation of ketone biosynthetic process(GO:0010566) regulation of aldosterone metabolic process(GO:0032344) regulation of aldosterone biosynthetic process(GO:0032347)
0.0	0.1	GO:0060831	smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:0060831)
0.0	0.2	GO:0046882	negative regulation of follicle-stimulating hormone secretion(GO:0046882)
0.0	0.2	GO:0010799	regulation of peptidyl-threonine phosphorylation(GO:0010799) positive regulation of peptidyl-threonine phosphorylation(GO:0010800)
0.0	0.2	GO:0001554	luteolysis(GO:0001554)
0.0	0.0	GO:0032277	negative regulation of gonadotropin secretion(GO:0032277)
0.0	0.4	GO:0034446	substrate adhesion-dependent cell spreading(GO:0034446)
0.0	0.2	GO:0071277	cellular response to calcium ion(GO:0071277)
0.0	0.1	GO:2000178	negative regulation of neuroblast proliferation(GO:0007406) negative regulation of neural precursor cell proliferation(GO:2000178)
0.0	0.1	GO:0051834	evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.0	0.2	GO:0015840	urea transport(GO:0015840)
0.0	0.1	GO:0033603	positive regulation of dopamine secretion(GO:0033603)
0.0	0.1	GO:0031340	positive regulation of vesicle fusion(GO:0031340)
0.0	0.0	GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.0	0.1	GO:0070779	D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0	0.2	GO:2000095	regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000095)
0.0	0.2	GO:0007386	compartment pattern specification(GO:0007386)
0.0	0.3	GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:0006978)
0.0	0.1	GO:0002248	connective tissue replacement involved in inflammatory response wound healing(GO:0002248) connective tissue replacement(GO:0097709)
0.0	0.1	GO:0046121	deoxyribonucleoside catabolic process(GO:0046121)
0.0	0.1	GO:0048149	behavioral response to ethanol(GO:0048149)
0.0	0.1	GO:0048845	venous blood vessel morphogenesis(GO:0048845)
0.0	0.1	GO:0060751	branch elongation involved in mammary gland duct branching(GO:0060751)
0.0	0.1	GO:0060317	cardiac epithelial to mesenchymal transition(GO:0060317)
0.0	0.1	GO:0033327	Leydig cell differentiation(GO:0033327)
0.0	0.2	GO:0002634	regulation of germinal center formation(GO:0002634)
0.0	0.2	GO:0007185	transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0	0.1	GO:1903053	regulation of extracellular matrix disassembly(GO:0010715) negative regulation of extracellular matrix disassembly(GO:0010716) regulation of extracellular matrix organization(GO:1903053) negative regulation of extracellular matrix organization(GO:1903054)
0.0	0.1	GO:0009169	purine nucleoside monophosphate catabolic process(GO:0009128) ribonucleoside monophosphate catabolic process(GO:0009158) purine ribonucleoside monophosphate catabolic process(GO:0009169)
0.0	0.1	GO:0090084	negative regulation of inclusion body assembly(GO:0090084)
0.0	0.1	GO:0014012	peripheral nervous system axon regeneration(GO:0014012)
0.0	0.1	GO:0060638	mesenchymal-epithelial cell signaling(GO:0060638)
0.0	0.1	GO:0006048	UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.0	0.2	GO:0033631	cell-cell adhesion mediated by integrin(GO:0033631)
0.0	0.1	GO:0048319	axial mesoderm morphogenesis(GO:0048319)
0.0	0.0	GO:0060510	lung saccule development(GO:0060430) Type II pneumocyte differentiation(GO:0060510)
0.0	0.1	GO:0045650	negative regulation of macrophage differentiation(GO:0045650)
0.0	0.1	GO:0019934	cGMP-mediated signaling(GO:0019934)
0.0	0.1	GO:0046951	ketone body biosynthetic process(GO:0046951)
0.0	0.1	GO:0005981	regulation of glycogen catabolic process(GO:0005981)
0.0	0.1	GO:0002043	blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.0	0.6	GO:0030199	collagen fibril organization(GO:0030199)
0.0	0.2	GO:0045075	interleukin-12 biosynthetic process(GO:0042090) regulation of interleukin-12 biosynthetic process(GO:0045075)
0.0	0.1	GO:0051497	negative regulation of stress fiber assembly(GO:0051497)
0.0	0.1	GO:0061081	positive regulation of myeloid leukocyte cytokine production involved in immune response(GO:0061081)
0.0	0.2	GO:0045749	obsolete negative regulation of S phase of mitotic cell cycle(GO:0045749)
0.0	0.1	GO:0001766	membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.0	0.1	GO:0032020	ISG15-protein conjugation(GO:0032020)
0.0	0.1	GO:0060900	optic cup morphogenesis involved in camera-type eye development(GO:0002072) embryonic camera-type eye formation(GO:0060900)
0.0	0.1	GO:0016103	diterpenoid catabolic process(GO:0016103) terpenoid catabolic process(GO:0016115) retinoic acid catabolic process(GO:0034653)
0.0	0.0	GO:0006824	cobalt ion transport(GO:0006824)
0.0	0.1	GO:0048702	embryonic neurocranium morphogenesis(GO:0048702)
0.0	0.6	GO:0010811	positive regulation of cell-substrate adhesion(GO:0010811)
0.0	0.1	GO:0032506	cytokinetic process(GO:0032506)
0.0	0.1	GO:0090273	regulation of somatostatin secretion(GO:0090273)
0.0	0.1	GO:0033173	calcineurin-NFAT signaling cascade(GO:0033173)
0.0	0.1	GO:0070672	response to interleukin-15(GO:0070672)
0.0	0.0	GO:0060242	contact inhibition(GO:0060242)
0.0	0.1	GO:0045898	regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0	0.1	GO:0009151	purine deoxyribonucleotide metabolic process(GO:0009151)
0.0	0.1	GO:0031641	regulation of myelination(GO:0031641)
0.0	0.1	GO:0015889	cobalamin transport(GO:0015889)
0.0	0.0	GO:0010761	fibroblast migration(GO:0010761)
0.0	0.1	GO:0051124	synaptic growth at neuromuscular junction(GO:0051124)
0.0	0.1	GO:0033314	mitotic DNA replication checkpoint(GO:0033314)
0.0	0.1	GO:0006398	mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.0	0.1	GO:0070874	negative regulation of glycogen metabolic process(GO:0070874)
0.0	0.0	GO:0021670	lateral ventricle development(GO:0021670)
0.0	0.1	GO:0032415	regulation of sodium:proton antiporter activity(GO:0032415) regulation of sodium ion transmembrane transport(GO:1902305) regulation of sodium ion transmembrane transporter activity(GO:2000649)
0.0	0.2	GO:0034384	high-density lipoprotein particle clearance(GO:0034384)
0.0	0.2	GO:0043030	regulation of macrophage activation(GO:0043030)
0.0	0.0	GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway(GO:0010803)
0.0	0.0	GO:0055089	fatty acid homeostasis(GO:0055089)
0.0	0.0	GO:0003308	regulation of Wnt signaling pathway involved in heart development(GO:0003307) negative regulation of Wnt signaling pathway involved in heart development(GO:0003308) regulation of heart induction by regulation of canonical Wnt signaling pathway(GO:0090081)
0.0	0.1	GO:0042487	regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.0	0.1	GO:0032509	endosome transport via multivesicular body sorting pathway(GO:0032509)
0.0	0.1	GO:0001778	plasma membrane repair(GO:0001778)
0.0	0.1	GO:0006930	substrate-dependent cell migration, cell extension(GO:0006930)
0.0	0.1	GO:0032780	negative regulation of ATPase activity(GO:0032780)
0.0	0.0	GO:0048791	calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0	0.1	GO:0006734	NADH metabolic process(GO:0006734)
0.0	0.0	GO:0046639	negative regulation of alpha-beta T cell differentiation(GO:0046639)
0.0	0.0	GO:0060664	epithelial cell proliferation involved in salivary gland morphogenesis(GO:0060664)
0.0	0.2	GO:0046653	tetrahydrofolate metabolic process(GO:0046653)
0.0	0.2	GO:0007520	syncytium formation by plasma membrane fusion(GO:0000768) myoblast fusion(GO:0007520)
0.0	0.1	GO:0048311	mitochondrion distribution(GO:0048311)
0.0	0.1	GO:0046607	positive regulation of centrosome cycle(GO:0046607)
0.0	0.0	GO:0061318	renal filtration cell differentiation(GO:0061318) glomerular epithelium development(GO:0072010) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.0	0.2	GO:0048844	artery morphogenesis(GO:0048844)
0.0	0.1	GO:0031394	regulation of prostaglandin biosynthetic process(GO:0031392) positive regulation of prostaglandin biosynthetic process(GO:0031394) regulation of unsaturated fatty acid biosynthetic process(GO:2001279) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
0.0	0.0	GO:0070427	nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427)
0.0	0.0	GO:0009415	response to water deprivation(GO:0009414) response to water(GO:0009415)
0.0	0.1	GO:0032825	regulation of natural killer cell differentiation(GO:0032823) positive regulation of natural killer cell differentiation(GO:0032825)
0.0	0.1	GO:0007598	blood coagulation, extrinsic pathway(GO:0007598)
0.0	0.0	GO:0071502	cellular response to temperature stimulus(GO:0071502)
0.0	0.1	GO:0002283	neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312)
0.0	0.1	GO:0030579	ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0	0.0	GO:0072193	ureter smooth muscle development(GO:0072191) ureter smooth muscle cell differentiation(GO:0072193)
0.0	0.3	GO:0021846	cell proliferation in forebrain(GO:0021846)
0.0	0.1	GO:0001560	regulation of cell growth by extracellular stimulus(GO:0001560)
0.0	0.0	GO:0030202	heparin metabolic process(GO:0030202)
0.0	0.1	GO:0090136	epithelial cell-cell adhesion(GO:0090136)
0.0	0.1	GO:0000019	regulation of mitotic recombination(GO:0000019)
0.0	0.1	GO:0007412	axon target recognition(GO:0007412)
0.0	0.0	GO:0060684	epithelial-mesenchymal cell signaling(GO:0060684)
0.0	0.1	GO:0015871	choline transport(GO:0015871)
0.0	0.1	GO:0034393	positive regulation of muscle cell apoptotic process(GO:0010661) positive regulation of smooth muscle cell apoptotic process(GO:0034393)
0.0	0.3	GO:0048008	platelet-derived growth factor receptor signaling pathway(GO:0048008)
0.0	0.0	GO:0021798	forebrain dorsal/ventral pattern formation(GO:0021798)
0.0	0.1	GO:0006527	arginine catabolic process(GO:0006527)
0.0	0.0	GO:0001996	positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996)
0.0	0.0	GO:0009235	cobalamin metabolic process(GO:0009235)
0.0	0.1	GO:0071731	response to nitric oxide(GO:0071731)
0.0	0.3	GO:0030574	collagen catabolic process(GO:0030574)
0.0	0.0	GO:0051541	elastin metabolic process(GO:0051541)
0.0	0.1	GO:0001547	antral ovarian follicle growth(GO:0001547)
0.0	0.0	GO:0001553	luteinization(GO:0001553)
0.0	0.0	GO:0008215	spermine metabolic process(GO:0008215)
0.0	0.0	GO:0048631	regulation of skeletal muscle tissue growth(GO:0048631)
0.0	0.0	GO:0021555	midbrain-hindbrain boundary morphogenesis(GO:0021555)
0.0	0.1	GO:0071800	podosome assembly(GO:0071800)
0.0	0.0	GO:0015791	polyol transport(GO:0015791)
0.0	0.1	GO:0006857	oligopeptide transport(GO:0006857)
0.0	0.0	GO:1904251	regulation of bile acid biosynthetic process(GO:0070857) regulation of bile acid metabolic process(GO:1904251)
0.0	0.1	GO:0032410	negative regulation of transporter activity(GO:0032410)
0.0	0.0	GO:0060435	bronchiole development(GO:0060435)
0.0	0.1	GO:0090286	cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.0	0.0	GO:0003078	obsolete regulation of natriuresis(GO:0003078)
0.0	0.0	GO:0008354	germ cell migration(GO:0008354)
0.0	0.1	GO:0006108	malate metabolic process(GO:0006108)
0.0	0.1	GO:0060390	regulation of SMAD protein import into nucleus(GO:0060390)
0.0	0.0	GO:0009200	deoxyribonucleoside triphosphate metabolic process(GO:0009200)
0.0	0.0	GO:0010757	negative regulation of plasminogen activation(GO:0010757)
0.0	0.0	GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
0.0	0.0	GO:0051898	negative regulation of protein kinase B signaling(GO:0051898)
0.0	0.1	GO:0021930	cell proliferation in hindbrain(GO:0021534) cell proliferation in external granule layer(GO:0021924) cerebellar granule cell precursor proliferation(GO:0021930)
0.0	0.0	GO:0030388	fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0	0.1	GO:0044341	sodium-dependent phosphate transport(GO:0044341)
0.0	0.1	GO:0006654	phosphatidic acid biosynthetic process(GO:0006654)
0.0	0.0	GO:0045992	negative regulation of embryonic development(GO:0045992)
0.0	0.0	GO:0046877	regulation of saliva secretion(GO:0046877)
0.0	0.1	GO:0046426	negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0	0.1	GO:0008228	opsonization(GO:0008228)
0.0	0.0	GO:0008300	isoprenoid catabolic process(GO:0008300)
0.0	0.0	GO:0043457	regulation of cellular respiration(GO:0043457)
0.0	0.1	GO:0007350	blastoderm segmentation(GO:0007350)
0.0	0.0	GO:0030505	inorganic diphosphate transport(GO:0030505)
0.0	0.0	GO:0021978	telencephalon regionalization(GO:0021978)
0.0	0.1	GO:0044253	positive regulation of collagen metabolic process(GO:0010714) positive regulation of collagen biosynthetic process(GO:0032967) positive regulation of multicellular organismal metabolic process(GO:0044253)
0.0	0.0	GO:0007501	mesodermal cell fate specification(GO:0007501)
0.0	0.1	GO:0009629	response to gravity(GO:0009629)
0.0	0.0	GO:0002023	reduction of food intake in response to dietary excess(GO:0002023)
0.0	0.1	GO:0046498	S-adenosylhomocysteine metabolic process(GO:0046498)
0.0	0.0	GO:0045162	clustering of voltage-gated sodium channels(GO:0045162)
0.0	0.1	GO:0065005	protein-lipid complex assembly(GO:0065005)
0.0	0.1	GO:0016266	O-glycan processing(GO:0016266)
0.0	0.0	GO:0033023	mast cell homeostasis(GO:0033023) mast cell apoptotic process(GO:0033024) regulation of mast cell apoptotic process(GO:0033025)
0.0	0.0	GO:0060157	urinary bladder development(GO:0060157)
0.0	0.0	GO:0046325	negative regulation of glucose import(GO:0046325)
0.0	0.0	GO:0003032	detection of oxygen(GO:0003032)
0.0	0.0	GO:0000492	small nucleolar ribonucleoprotein complex assembly(GO:0000491) box C/D snoRNP assembly(GO:0000492)
0.0	0.1	GO:0042364	water-soluble vitamin biosynthetic process(GO:0042364)
0.0	0.1	GO:0046835	carbohydrate phosphorylation(GO:0046835)
0.0	0.2	GO:0006825	copper ion transport(GO:0006825)
0.0	0.0	GO:0090162	establishment of epithelial cell polarity(GO:0090162)
0.0	0.0	GO:0034201	response to oleic acid(GO:0034201)
0.0	0.2	GO:0015701	bicarbonate transport(GO:0015701)
0.0	0.0	GO:0030321	transepithelial chloride transport(GO:0030321)
0.0	0.0	GO:0032525	somite rostral/caudal axis specification(GO:0032525)
0.0	0.0	GO:0030309	poly-N-acetyllactosamine metabolic process(GO:0030309)
0.0	0.0	GO:0060159	regulation of dopamine receptor signaling pathway(GO:0060159)
0.0	0.0	GO:0014834	skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration(GO:0014834)
0.0	0.0	GO:0009106	lipoate metabolic process(GO:0009106)
0.0	0.0	GO:0070099	cerebral cortex tangential migration using cell-cell interactions(GO:0021823) substrate-dependent cerebral cortex tangential migration(GO:0021825) postnatal olfactory bulb interneuron migration(GO:0021827) Roundabout signaling pathway(GO:0035385) regulation of chemokine-mediated signaling pathway(GO:0070099) negative regulation of chemokine-mediated signaling pathway(GO:0070100)
0.0	0.0	GO:0006432	phenylalanyl-tRNA aminoacylation(GO:0006432)
0.0	0.0	GO:0032222	regulation of synaptic transmission, cholinergic(GO:0032222)
0.0	0.1	GO:0032332	positive regulation of chondrocyte differentiation(GO:0032332)
0.0	0.0	GO:0034063	stress granule assembly(GO:0034063)
0.0	0.0	GO:0001757	somite specification(GO:0001757)
0.0	0.1	GO:0016540	protein autoprocessing(GO:0016540)
0.0	0.0	GO:0010842	retina layer formation(GO:0010842)
0.0	0.0	GO:0003099	positive regulation of the force of heart contraction by chemical signal(GO:0003099)
0.0	0.1	GO:0006693	prostaglandin metabolic process(GO:0006693)
0.0	0.2	GO:0045104	intermediate filament cytoskeleton organization(GO:0045104)
0.0	0.0	GO:0060433	bronchus development(GO:0060433)
0.0	0.1	GO:0007199	G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger(GO:0007199)
0.0	0.0	GO:0039656	modulation by virus of host gene expression(GO:0039656)
0.0	0.0	GO:0009396	folic acid-containing compound biosynthetic process(GO:0009396)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0030934	anchoring collagen complex(GO:0030934)
0.1	0.4	GO:0030056	hemidesmosome(GO:0030056)
0.1	0.1	GO:0071664	catenin-TCF7L2 complex(GO:0071664)
0.1	0.2	GO:0005862	muscle thin filament tropomyosin(GO:0005862)
0.1	0.6	GO:0098643	fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1	0.2	GO:0005589	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.1	0.2	GO:0043259	laminin-10 complex(GO:0043259)
0.0	0.3	GO:0008290	F-actin capping protein complex(GO:0008290)
0.0	0.1	GO:0044298	neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0	0.3	GO:0098642	network-forming collagen trimer(GO:0098642) collagen network(GO:0098645)
0.0	0.1	GO:0070083	clathrin-sculpted monoamine transport vesicle(GO:0070081) clathrin-sculpted monoamine transport vesicle membrane(GO:0070083)
0.0	0.0	GO:0098651	basement membrane collagen trimer(GO:0098651)
0.0	0.2	GO:0031588	nucleotide-activated protein kinase complex(GO:0031588)
0.0	0.1	GO:0005900	oncostatin-M receptor complex(GO:0005900)
0.0	0.1	GO:0070852	cell body fiber(GO:0070852)
0.0	0.2	GO:0031143	pseudopodium(GO:0031143)
0.0	0.1	GO:0071256	Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.0	0.2	GO:0005614	interstitial matrix(GO:0005614)
0.0	0.2	GO:0030673	axolemma(GO:0030673)
0.0	0.1	GO:0060199	clathrin-sculpted glutamate transport vesicle(GO:0060199) clathrin-sculpted glutamate transport vesicle membrane(GO:0060203)
0.0	0.1	GO:0071437	invadopodium(GO:0071437)
0.0	0.1	GO:1903561	extracellular exosome(GO:0070062) extracellular vesicle(GO:1903561)
0.0	0.2	GO:0005916	fascia adherens(GO:0005916)
0.0	0.1	GO:0032045	guanyl-nucleotide exchange factor complex(GO:0032045)
0.0	0.1	GO:0009331	glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.0	0.0	GO:0005899	insulin receptor complex(GO:0005899)
0.0	0.2	GO:0005577	fibrinogen complex(GO:0005577)
0.0	0.2	GO:0008091	spectrin(GO:0008091)
0.0	0.1	GO:0031931	TORC1 complex(GO:0031931)
0.0	0.1	GO:0005915	zonula adherens(GO:0005915)
0.0	0.1	GO:0010369	chromocenter(GO:0010369)
0.0	0.1	GO:0031232	extrinsic component of external side of plasma membrane(GO:0031232)
0.0	0.1	GO:0044291	intercalated disc(GO:0014704) cell-cell contact zone(GO:0044291)
0.0	0.6	GO:0030018	Z disc(GO:0030018)
0.0	0.3	GO:0009925	basal plasma membrane(GO:0009925)
0.0	0.1	GO:0000445	THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.0	0.1	GO:0045254	pyruvate dehydrogenase complex(GO:0045254)
0.0	0.1	GO:0034673	inhibin-betaglycan-ActRII complex(GO:0034673)
0.0	0.2	GO:0030669	clathrin-coated endocytic vesicle membrane(GO:0030669)
0.0	0.4	GO:0001725	stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0	0.1	GO:0005766	primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.0	0.1	GO:0005954	calcium- and calmodulin-dependent protein kinase complex(GO:0005954)
0.0	0.2	GO:0031233	intrinsic component of external side of plasma membrane(GO:0031233)
0.0	0.0	GO:0043656	host(GO:0018995) host cell part(GO:0033643) host intracellular part(GO:0033646) intracellular region of host(GO:0043656) host cell(GO:0043657) other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217)
0.0	0.1	GO:0032777	Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0	0.1	GO:0005847	mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0	0.0	GO:0032432	actin filament bundle(GO:0032432)
0.0	0.1	GO:0035145	exon-exon junction complex(GO:0035145)
0.0	0.1	GO:0016012	sarcoglycan complex(GO:0016012)
0.0	0.1	GO:0002102	podosome(GO:0002102)
0.0	0.2	GO:0005833	hemoglobin complex(GO:0005833)
0.0	0.0	GO:0043625	delta DNA polymerase complex(GO:0043625)
0.0	0.0	GO:0008282	ATP-sensitive potassium channel complex(GO:0008282)
0.0	0.1	GO:0042581	specific granule(GO:0042581)
0.0	0.1	GO:0005697	telomerase holoenzyme complex(GO:0005697)
0.0	0.1	GO:0005641	nuclear envelope lumen(GO:0005641)
0.0	0.6	GO:0043197	dendritic spine(GO:0043197)
0.0	0.0	GO:0043083	synaptic cleft(GO:0043083)
0.0	0.0	GO:0005945	6-phosphofructokinase complex(GO:0005945)
0.0	0.1	GO:0071547	piP-body(GO:0071547)
0.0	0.1	GO:0072669	tRNA-splicing ligase complex(GO:0072669)
0.0	0.4	GO:0008305	integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.0	0.1	GO:0032585	multivesicular body membrane(GO:0032585)
0.0	0.2	GO:0042588	zymogen granule(GO:0042588)
0.0	0.1	GO:0030315	T-tubule(GO:0030315)
0.0	0.0	GO:0033268	node of Ranvier(GO:0033268)
0.0	0.1	GO:0048786	presynaptic active zone(GO:0048786)
0.0	0.2	GO:0005811	lipid particle(GO:0005811)
0.0	0.3	GO:0034704	calcium channel complex(GO:0034704)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0001099	basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.1	0.4	GO:0030297	transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.1	0.4	GO:0004322	ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.1	0.3	GO:0051371	muscle alpha-actinin binding(GO:0051371)
0.1	0.2	GO:0019834	phospholipase A2 inhibitor activity(GO:0019834)
0.1	0.3	GO:0005010	insulin-like growth factor-activated receptor activity(GO:0005010)
0.1	0.2	GO:0005006	epidermal growth factor-activated receptor activity(GO:0005006)
0.1	0.2	GO:0004687	myosin light chain kinase activity(GO:0004687)
0.1	0.2	GO:0015204	urea transmembrane transporter activity(GO:0015204)
0.1	0.4	GO:0017154	semaphorin receptor activity(GO:0017154)
0.1	0.2	GO:0050508	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.1	0.1	GO:0050544	arachidonic acid binding(GO:0050544)
0.1	0.2	GO:0008510	sodium:bicarbonate symporter activity(GO:0008510)
0.1	0.2	GO:0045545	syndecan binding(GO:0045545)
0.1	0.2	GO:0042805	actinin binding(GO:0042805)
0.1	0.4	GO:0017166	vinculin binding(GO:0017166)
0.1	0.3	GO:0030507	spectrin binding(GO:0030507)
0.0	0.1	GO:0003829	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0003829)
0.0	0.2	GO:0005315	inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0	0.1	GO:0030375	thyroid hormone receptor coactivator activity(GO:0030375)
0.0	0.9	GO:0008093	cytoskeletal adaptor activity(GO:0008093)
0.0	0.2	GO:0017112	Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0	0.1	GO:0050501	hyaluronan synthase activity(GO:0050501)
0.0	0.2	GO:0008607	phosphorylase kinase regulator activity(GO:0008607)
0.0	0.3	GO:0004955	prostaglandin receptor activity(GO:0004955)
0.0	0.1	GO:0005173	stem cell factor receptor binding(GO:0005173)
0.0	0.1	GO:0043559	insulin binding(GO:0043559)
0.0	0.1	GO:0004924	oncostatin-M receptor activity(GO:0004924)
0.0	0.1	GO:0047023	androsterone dehydrogenase activity(GO:0047023)
0.0	0.1	GO:0070052	collagen V binding(GO:0070052)
0.0	0.4	GO:0048407	platelet-derived growth factor binding(GO:0048407)
0.0	0.1	GO:0010314	phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0	0.1	GO:0004470	malic enzyme activity(GO:0004470)
0.0	1.1	GO:0005518	collagen binding(GO:0005518)
0.0	0.2	GO:0046790	virion binding(GO:0046790)
0.0	0.1	GO:0004656	procollagen-proline 4-dioxygenase activity(GO:0004656) peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.0	0.0	GO:0050543	icosatetraenoic acid binding(GO:0050543)
0.0	0.3	GO:0051010	microtubule plus-end binding(GO:0051010)
0.0	0.2	GO:0005110	frizzled-2 binding(GO:0005110)
0.0	0.1	GO:0002162	dystroglycan binding(GO:0002162)
0.0	0.1	GO:0030215	semaphorin receptor binding(GO:0030215)
0.0	0.1	GO:0016882	cyclo-ligase activity(GO:0016882)
0.0	0.1	GO:0004157	dihydropyrimidinase activity(GO:0004157)
0.0	0.2	GO:0070696	transmembrane receptor protein serine/threonine kinase binding(GO:0070696)
0.0	0.1	GO:0004528	phosphodiesterase I activity(GO:0004528)
0.0	0.1	GO:0070324	thyroid hormone binding(GO:0070324)
0.0	0.1	GO:0042608	T cell receptor binding(GO:0042608)
0.0	0.1	GO:0003680	AT DNA binding(GO:0003680)
0.0	0.0	GO:0048018	receptor agonist activity(GO:0048018)
0.0	0.0	GO:0061133	endopeptidase activator activity(GO:0061133)
0.0	0.2	GO:0022821	potassium ion antiporter activity(GO:0022821)
0.0	0.3	GO:0005523	tropomyosin binding(GO:0005523)
0.0	0.1	GO:0015279	store-operated calcium channel activity(GO:0015279)
0.0	0.1	GO:0004340	glucokinase activity(GO:0004340)
0.0	0.1	GO:0008429	phosphatidylethanolamine binding(GO:0008429)
0.0	0.2	GO:0030332	cyclin binding(GO:0030332)
0.0	0.1	GO:0004367	glycerol-3-phosphate dehydrogenase [NAD+] activity(GO:0004367)
0.0	0.1	GO:0004645	phosphorylase activity(GO:0004645)
0.0	0.3	GO:0004012	phospholipid-translocating ATPase activity(GO:0004012)
0.0	0.1	GO:0050253	retinyl-palmitate esterase activity(GO:0050253)
0.0	0.1	GO:0004321	fatty-acyl-CoA synthase activity(GO:0004321)
0.0	0.1	GO:0005314	high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.0	0.1	GO:0048495	Roundabout binding(GO:0048495)
0.0	0.1	GO:0004117	calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117)
0.0	0.1	GO:0016748	succinyltransferase activity(GO:0016748)
0.0	0.1	GO:0004465	lipoprotein lipase activity(GO:0004465)
0.0	0.1	GO:0043495	protein anchor(GO:0043495)
0.0	0.2	GO:0045295	gamma-catenin binding(GO:0045295)
0.0	0.1	GO:0016972	thiol oxidase activity(GO:0016972)
0.0	0.1	GO:0016635	oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor(GO:0016635)
0.0	0.1	GO:0008331	high voltage-gated calcium channel activity(GO:0008331)
0.0	0.1	GO:0004969	histamine receptor activity(GO:0004969)
0.0	0.2	GO:0001968	fibronectin binding(GO:0001968)
0.0	0.1	GO:0008401	retinoic acid 4-hydroxylase activity(GO:0008401)
0.0	0.1	GO:0030020	extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.0	0.1	GO:0034056	estrogen response element binding(GO:0034056)
0.0	0.1	GO:0033130	acetylcholine receptor binding(GO:0033130)
0.0	0.1	GO:0004720	protein-lysine 6-oxidase activity(GO:0004720)
0.0	0.1	GO:0004791	thioredoxin-disulfide reductase activity(GO:0004791)
0.0	0.1	GO:0008504	monoamine transmembrane transporter activity(GO:0008504)
0.0	0.1	GO:0004967	glucagon receptor activity(GO:0004967)
0.0	0.1	GO:0048027	mRNA 5'-UTR binding(GO:0048027)
0.0	0.1	GO:0032296	ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296)
0.0	0.1	GO:0008035	high-density lipoprotein particle binding(GO:0008035)
0.0	0.1	GO:0005030	neurotrophin receptor activity(GO:0005030)
0.0	0.2	GO:0005161	platelet-derived growth factor receptor binding(GO:0005161)
0.0	0.0	GO:0004939	beta-adrenergic receptor activity(GO:0004939)
0.0	0.0	GO:0004332	fructose-bisphosphate aldolase activity(GO:0004332)
0.0	0.1	GO:0035252	UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285)
0.0	0.1	GO:0004597	peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.0	0.0	GO:0004800	thyroxine 5'-deiodinase activity(GO:0004800)
0.0	0.1	GO:0047429	nucleoside-triphosphate diphosphatase activity(GO:0047429)
0.0	0.0	GO:0000404	heteroduplex DNA loop binding(GO:0000404)
0.0	0.0	GO:0015199	amino-acid betaine transmembrane transporter activity(GO:0015199) carnitine transmembrane transporter activity(GO:0015226)
0.0	0.0	GO:0016623	oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor(GO:0016623)
0.0	0.1	GO:0016933	extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.0	0.1	GO:0070087	chromo shadow domain binding(GO:0070087)
0.0	0.3	GO:0017147	Wnt-protein binding(GO:0017147)
0.0	0.1	GO:0030274	LIM domain binding(GO:0030274)
0.0	0.0	GO:0016842	amidine-lyase activity(GO:0016842)
0.0	0.2	GO:0015269	calcium-activated potassium channel activity(GO:0015269)
0.0	0.0	GO:0019215	intermediate filament binding(GO:0019215)
0.0	0.0	GO:0003872	6-phosphofructokinase activity(GO:0003872)
0.0	0.0	GO:0042813	Wnt-activated receptor activity(GO:0042813)
0.0	0.1	GO:0008020	G-protein coupled photoreceptor activity(GO:0008020)
0.0	0.2	GO:0048365	Rac GTPase binding(GO:0048365)
0.0	0.1	GO:0004083	bisphosphoglycerate mutase activity(GO:0004082) bisphosphoglycerate 2-phosphatase activity(GO:0004083) phosphoglycerate mutase activity(GO:0004619)
0.0	0.1	GO:0004032	alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.0	0.1	GO:0008253	5'-nucleotidase activity(GO:0008253)
0.0	0.2	GO:0008603	cAMP-dependent protein kinase regulator activity(GO:0008603)
0.0	0.0	GO:0042289	MHC class II protein binding(GO:0042289)
0.0	0.1	GO:0015220	choline transmembrane transporter activity(GO:0015220)
0.0	0.0	GO:0015038	glutathione disulfide oxidoreductase activity(GO:0015038)
0.0	0.8	GO:0005201	extracellular matrix structural constituent(GO:0005201)
0.0	0.0	GO:0005172	vascular endothelial growth factor receptor binding(GO:0005172)
0.0	0.1	GO:0016641	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641)
0.0	0.1	GO:0070628	proteasome binding(GO:0070628)
0.0	0.1	GO:0048185	activin binding(GO:0048185)
0.0	0.0	GO:0008327	methyl-CpG binding(GO:0008327)
0.0	0.0	GO:0000403	Y-form DNA binding(GO:0000403)
0.0	0.0	GO:0050698	proteoglycan sulfotransferase activity(GO:0050698)
0.0	0.1	GO:0042056	chemoattractant activity(GO:0042056)
0.0	0.1	GO:0001871	pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0	0.1	GO:0009374	biotin binding(GO:0009374)
0.0	0.1	GO:0016813	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.0	0.0	GO:0004596	peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0	0.2	GO:0004364	glutathione transferase activity(GO:0004364)
0.0	0.0	GO:0042910	xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.0	0.0	GO:0016668	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668)
0.0	0.1	GO:0070290	N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0	0.2	GO:0005520	insulin-like growth factor binding(GO:0005520)
0.0	0.1	GO:0016500	protein-hormone receptor activity(GO:0016500)
0.0	0.0	GO:0004995	tachykinin receptor activity(GO:0004995)
0.0	0.1	GO:0016174	NAD(P)H oxidase activity(GO:0016174)
0.0	0.0	GO:0045499	chemorepellent activity(GO:0045499)
0.0	0.0	GO:0030284	estrogen receptor activity(GO:0030284)
0.0	0.1	GO:0008242	omega peptidase activity(GO:0008242)
0.0	0.0	GO:0060230	lipoprotein lipase activator activity(GO:0060230)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.4	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
0.6	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.1	PID ECADHERIN KERATINOCYTE PATHWAY	E-cadherin signaling in keratinocytes
0.6	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
1.2	NABA COLLAGENS	Genes encoding collagen proteins
0.1	PID TXA2PATHWAY	Thromboxane A2 receptor signaling
0.0	PID PDGFRA PATHWAY	PDGFR-alpha signaling pathway
0.0	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
0.2	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0	ST GRANULE CELL SURVIVAL PATHWAY	Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.5	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.2	PID ARF 3PATHWAY	Arf1 pathway
0.3	NABA BASEMENT MEMBRANES	Genes encoding structural components of basement membranes
0.0	PID GLYPICAN 1PATHWAY	Glypican 1 network
0.4	PID FRA PATHWAY	Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1	PID INTEGRIN CS PATHWAY	Integrin family cell surface interactions

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.6	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.0	1.1	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.0	0.4	REACTOME PROSTANOID LIGAND RECEPTORS	Genes involved in Prostanoid ligand receptors
0.0	0.4	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.0	0.0	REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR	Genes involved in Prostacyclin signalling through prostacyclin receptor
0.0	1.4	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.0	0.0	REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS	Genes involved in Nucleotide-like (purinergic) receptors
0.0	0.2	REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK	Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0	0.6	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.0	0.2	REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII	Genes involved in CREB phosphorylation through the activation of CaMKII
0.0	0.2	REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS	Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0	0.4	REACTOME GRB2 EVENTS IN ERBB2 SIGNALING	Genes involved in GRB2 events in ERBB2 signaling
0.0	0.2	REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE	Genes involved in Synthesis of PIPs at the late endosome membrane
0.0	0.1	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
0.0	0.0	REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS	Genes involved in Synthesis of bile acids and bile salts
0.0	0.0	REACTOME PHOSPHORYLATION OF THE APC C	Genes involved in Phosphorylation of the APC/C
0.0	0.2	REACTOME HYALURONAN METABOLISM	Genes involved in Hyaluronan metabolism
0.0	0.2	REACTOME CRMPS IN SEMA3A SIGNALING	Genes involved in CRMPs in Sema3A signaling
0.0	0.0	REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS	Genes involved in Membrane binding and targetting of GAG proteins
0.0	0.1	REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING	Genes involved in Role of second messengers in netrin-1 signaling
0.0	0.0	REACTOME ALPHA LINOLENIC ACID ALA METABOLISM	Genes involved in alpha-linolenic acid (ALA) metabolism
0.0	0.2	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0	0.1	REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES	Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0	0.2	REACTOME PEPTIDE HORMONE BIOSYNTHESIS	Genes involved in Peptide hormone biosynthesis
0.0	0.1	REACTOME KERATAN SULFATE DEGRADATION	Genes involved in Keratan sulfate degradation
0.0	0.1	REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES	Genes involved in p75NTR recruits signalling complexes
0.0	0.0	REACTOME NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION	Genes involved in Nuclear Events (kinase and transcription factor activation)
0.0	0.0	REACTOME DESTABILIZATION OF MRNA BY BRF1	Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.0	0.1	REACTOME POL SWITCHING	Genes involved in Polymerase switching
0.0	0.0	REACTOME REGULATION OF INSULIN SECRETION BY GLUCAGON LIKE PEPTIDE1	Genes involved in Regulation of Insulin Secretion by Glucagon-like Peptide-1
0.0	0.0	REACTOME RNA POL I PROMOTER OPENING	Genes involved in RNA Polymerase I Promoter Opening