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ENCODE: H3K4me1 ChIP-Seq of primary human cells

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Results for NFATC2_NFATC3

Z-value: 1.16

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Transcription factors associated with NFATC2_NFATC3

Gene Symbol	Gene ID	Gene Info
NFATC2 Ensembl NCBI GeneCards UniProt	ENSG00000101096.15	nuclear factor of activated T cells 2
NFATC3 Ensembl NCBI GeneCards UniProt	ENSG00000072736.14	nuclear factor of activated T cells 3

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
chr20_50267234_50267411	NFATC2	87952	0.088396	-0.81	7.6e-03	Click!
chr20_50114560_50114910	NFATC2	44523	0.160320	0.79	1.1e-02	Click!
chr20_50149036_50149205	NFATC2	10138	0.277007	0.72	2.8e-02	Click!
chr20_50178402_50178669	NFATC2	633	0.822278	0.70	3.5e-02	Click!
chr20_50268856_50269051	NFATC2	89583	0.086005	-0.70	3.7e-02	Click!
chr16_68156720_68156871	NFATC3	138	0.935369	0.70	3.7e-02	Click!
chr16_68165442_68165593	NFATC3	8584	0.120729	0.66	5.2e-02	Click!
chr16_68156053_68156204	NFATC3	805	0.505144	0.65	5.9e-02	Click!
chr16_68150771_68150922	NFATC3	6087	0.127355	0.51	1.6e-01	Click!
chr16_68180865_68181016	NFATC3	24007	0.095014	0.50	1.7e-01	Click!

Activity of the NFATC2_NFATC3 motif across conditions

Conditions sorted by the z-value of the NFATC2_NFATC3 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chrX_153554805_153555132	0.33	XX-FW83128A1.2		8419	0.1
chr9_36456515_36456814	0.31	RNF38	ring finger protein 38	55469	0.14
chr3_113941510_113941806	0.30	RP11-553L6.2		8420	0.17
chr3_10478219_10478442	0.30	ATP2B2	ATPase, Ca++ transporting, plasma membrane 2	12967	0.17
chr4_146750710_146751189	0.29	RP11-181K12.2		3321	0.32
chr21_34934879_34935141	0.29	SON	SON DNA binding protein	7655	0.13
chr11_35268427_35268939	0.28	SLC1A2	solute carrier family 1 (glial high affinity glutamate transporter), member 2	18609	0.14
chr13_114912317_114912766	0.28	RASA3	RAS p21 protein activator 3	14455	0.21
chr6_143172108_143172466	0.26	HIVEP2	human immunodeficiency virus type I enhancer binding protein 2	14103	0.27
chr11_73943038_73943344	0.25	PPME1	protein phosphatase methylesterase 1	1361	0.4
chr3_106053434_106053826	0.25	ENSG00000200610	.	181114	0.03
chr2_169607962_169608413	0.24	CERS6-AS1	CERS6 antisense RNA 1	33111	0.18
chr11_104940044_104940294	0.24	CARD16	caspase recruitment domain family, member 16	24066	0.15
chr14_61972853_61973004	0.24	RP11-47I22.4		22918	0.18
chr13_114914753_114915138	0.24	RASA3	RAS p21 protein activator 3	16859	0.2
chr2_204587544_204587695	0.24	CD28	CD28 molecule	16203	0.22
chr14_53576594_53576777	0.24	DDHD1	DDHD domain containing 1	40119	0.14
chr5_126187384_126187849	0.24	MARCH3	membrane-associated ring finger (C3HC4) 3, E3 ubiquitin protein ligase	66304	0.11
chr1_19727907_19728317	0.23	CAPZB	capping protein (actin filament) muscle Z-line, beta	15821	0.15
chr8_134578488_134578789	0.23	ST3GAL1	ST3 beta-galactoside alpha-2,3-sialyltransferase 1	5454	0.32
chr1_167468557_167468835	0.23	CD247	CD247 molecule	19079	0.18
chr8_29945094_29945295	0.22	TMEM66	transmembrane protein 66	4471	0.16
chr16_89379947_89380415	0.22	AC137932.6		7360	0.13
chr20_3888441_3888812	0.22	ENSG00000199024	.	9515	0.15
chr8_121718949_121719418	0.22	RP11-713M15.1		54310	0.15
chrX_6978429_6978580	0.22	ENSG00000264268	.	87397	0.09
chr17_1775725_1776037	0.22	RPA1	replication protein A1, 70kDa	6448	0.16
chr16_68156720_68156871	0.22	NFATC3	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3	138	0.94
chr8_129554302_129554520	0.22	ENSG00000221351	.	277629	0.01
chr11_95748251_95748505	0.22	MTMR2	myotubularin related protein 2	90919	0.09
chr11_12696899_12697155	0.21	TEAD1	TEA domain family member 1 (SV40 transcriptional enhancer factor)	23	0.99
chr7_640540_641424	0.21	PRKAR1B	protein kinase, cAMP-dependent, regulatory, type I, beta	1338	0.36
chr9_6893208_6893630	0.21	RP11-403H13.1		9251	0.26
chr11_85460900_85461152	0.21	SYTL2	synaptotagmin-like 2	7742	0.22
chr16_82686752_82686952	0.21	CDH13	cadherin 13	26154	0.24
chr17_80083513_80083920	0.21	CCDC57	coiled-coil domain containing 57	2716	0.14
chr8_60010060_60010211	0.20	RP11-25K19.1		21464	0.19
chr1_167469197_167469632	0.20	CD247	CD247 molecule	18361	0.19
chr14_98691862_98692070	0.20	ENSG00000222066	.	106121	0.08
chr5_110569357_110569585	0.20	CAMK4	calcium/calmodulin-dependent protein kinase IV	9687	0.23
chrX_73512873_73513290	0.20	ENSG00000199168	.	5889	0.15
chr12_46918323_46918580	0.20	SLC38A2	solute carrier family 38, member 2	151801	0.04
chr8_126941263_126941691	0.20	ENSG00000206695	.	28282	0.26
chr8_125656871_125657085	0.19	RP11-532M24.1		65106	0.1
chr1_147234394_147234673	0.19	GJA5	gap junction protein, alpha 5, 40kDa	1848	0.35
chr12_66685588_66685946	0.19	ENSG00000222744	.	696	0.65
chr1_100908166_100908711	0.19	RP5-837M10.4		43115	0.14
chr20_50028653_50029381	0.19	ENSG00000263645	.	35159	0.18
chr19_47679735_47680100	0.19	SAE1	SUMO1 activating enzyme subunit 1	45765	0.09
chr9_73005938_73006420	0.19	KLF9	Kruppel-like factor 9	23361	0.23
chr14_98440597_98440771	0.19	C14orf64	chromosome 14 open reading frame 64	3699	0.39
chr9_35941319_35941531	0.19	RP11-327L3.3		11416	0.14
chr13_74831431_74831622	0.19	ENSG00000206617	.	31825	0.24
chr4_147371793_147371944	0.19	SLC10A7	solute carrier family 10, member 7	71001	0.12
chr7_151192237_151192388	0.19	RHEB	Ras homolog enriched in brain	22843	0.14
chr2_204815355_204815506	0.19	ICOS	inducible T-cell co-stimulator	13927	0.27
chr17_63258830_63258981	0.19	RGS9	regulator of G-protein signaling 9	125313	0.05
chr17_38779166_38779543	0.19	SMARCE1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1	9188	0.15
chr5_66452974_66453257	0.19	MAST4	microtubule associated serine/threonine kinase family member 4	14853	0.25
chr1_89729146_89729620	0.19	RP4-620F22.2		3118	0.24
chr21_43825047_43825198	0.19	UBASH3A	ubiquitin associated and SH3 domain containing A	1096	0.4
chr21_43836247_43836423	0.19	ENSG00000252619	.	1367	0.33
chr3_4889780_4890066	0.19	ENSG00000239126	.	30463	0.18
chr12_28370089_28370389	0.19	CCDC91	coiled-coil domain containing 91	26061	0.2
chr19_18761669_18761820	0.18	KLHL26	kelch-like family member 26	13877	0.1
chr2_30475826_30476132	0.18	LBH	limb bud and heart development	20933	0.22
chr11_65871587_65871878	0.18	PACS1	phosphofurin acidic cluster sorting protein 1	3498	0.14
chr14_98664260_98664734	0.18	ENSG00000222066	.	133590	0.05
chr6_112178470_112178652	0.18	FYN	FYN oncogene related to SRC, FGR, YES	1025	0.67
chr1_9774183_9774336	0.18	PIK3CD	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta	3868	0.21
chr22_45570475_45570814	0.18	CTA-268H5.12		4227	0.19
chr16_10831978_10832129	0.18	NUBP1	nucleotide binding protein 1	5590	0.19
chr17_80943374_80943845	0.18	RP11-1197K16.2		4651	0.24
chr1_28296104_28296455	0.18	RP11-460I13.2		9575	0.13
chr2_85077049_85077200	0.18	TRABD2A	TraB domain containing 2A	31082	0.16
chr8_2080105_2080333	0.18	MYOM2	myomesin 2	87035	0.1
chr8_145809113_145809328	0.18	CTD-2517M22.9		204	0.88
chr5_137901949_137902139	0.18	ENSG00000206989	.	5245	0.14
chr8_20294178_20294391	0.18	LZTS1	leucine zipper, putative tumor suppressor 1	132810	0.05
chr15_44269346_44269630	0.18	FRMD5	FERM domain containing 5	52981	0.12
chr7_142500544_142500721	0.18	PRSS3P2	protease, serine, 3 pseudogene 2	19501	0.16
chr20_61829301_61829452	0.18	YTHDF1	YTH domain family, member 1	10594	0.13
chr3_71485366_71485556	0.18	ENSG00000221264	.	105779	0.07
chr1_159013727_159013878	0.18	ENSG00000265589	.	15237	0.17
chr3_177513850_177514001	0.17	ENSG00000200288	.	171728	0.04
chr18_2577782_2577933	0.17	NDC80	NDC80 kinetochore complex component	9	0.97
chr3_16549805_16550351	0.17	RFTN1	raftlin, lipid raft linker 1	4333	0.31
chr11_45396634_45396934	0.17	SYT13	synaptotagmin XIII	88914	0.09
chrX_49148626_49148900	0.17	GAGE10	G antigen 10	11385	0.08
chr3_16326422_16326573	0.17	OXNAD1	oxidoreductase NAD-binding domain containing 1	15749	0.16
chr4_38513354_38513505	0.17	RP11-617D20.1		112767	0.06
chr15_59519587_59519738	0.17	MYO1E	myosin IE	127	0.94
chr18_18673078_18673254	0.17	ROCK1	Rho-associated, coiled-coil containing protein kinase 1	18646	0.19
chr1_26003341_26003560	0.17	RP1-187B23.1		17848	0.17
chr1_154237482_154237741	0.17	ENSG00000201129	.	5408	0.09
chr20_37503628_37504045	0.17	ENSG00000240474	.	2423	0.3
chr2_175481766_175482174	0.17	WIPF1	WAS/WASL interacting protein family, member 1	17337	0.19
chrX_9916495_9916646	0.17	AC002365.1	Homo sapiens uncharacterized LOC100288814 (LOC100288814), mRNA.	18822	0.18
chr4_90210818_90211002	0.17	GPRIN3	GPRIN family member 3	18251	0.28
chr2_158277456_158277614	0.17	CYTIP	cytohesin 1 interacting protein	18391	0.2
chr5_54391521_54391672	0.16	GZMA	granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)	6880	0.15
chr1_117303333_117303484	0.16	CD2	CD2 molecule	6319	0.23
chr5_110564408_110564849	0.16	CAMK4	calcium/calmodulin-dependent protein kinase IV	4844	0.26
chr12_54746256_54746507	0.16	RP11-753H16.3		1064	0.24
chr3_114011081_114011232	0.16	TIGIT	T cell immunoreceptor with Ig and ITIM domains	1207	0.46
chr14_63979608_63979759	0.16	PPP2R5E	protein phosphatase 2, regulatory subunit B', epsilon isoform	4728	0.18
chr9_132219969_132220120	0.16	ENSG00000264298	.	20791	0.2
chr17_2157497_2157648	0.16	SMG6	SMG6 nonsense mediated mRNA decay factor	9366	0.12
chr10_44311022_44311286	0.16	ZNF32	zinc finger protein 32	166850	0.03
chr10_44312151_44312815	0.16	ZNF32	zinc finger protein 32	168179	0.03
chr13_41174871_41175165	0.16	AL133318.1	Uncharacterized protein	63695	0.11
chr11_128175433_128175800	0.16	ETS1	v-ets avian erythroblastosis virus E26 oncogene homolog 1	199673	0.03
chr8_41644430_41644581	0.16	ANK1	ankyrin 1, erythrocytic	10635	0.18
chr7_648989_649179	0.16	AC147651.4		6262	0.19
chr6_154563218_154563545	0.16	IPCEF1	interaction protein for cytohesin exchange factors 1	4609	0.35
chr1_25290472_25290639	0.16	RUNX3	runt-related transcription factor 3	920	0.57
chr7_27386191_27386342	0.16	EVX1-AS	EVX1 antisense RNA	99418	0.05
chr21_32519368_32519782	0.16	TIAM1	T-cell lymphoma invasion and metastasis 1	17036	0.27
chr8_42013873_42014024	0.16	AP3M2	adaptor-related protein complex 3, mu 2 subunit	1511	0.35
chr1_90126085_90126236	0.16	LRRC8C	leucine rich repeat containing 8 family, member C	27529	0.15
chr6_37473145_37473463	0.16	CCDC167	coiled-coil domain containing 167	5606	0.22
chr13_99208991_99209442	0.16	STK24	serine/threonine kinase 24	19901	0.19
chr15_89291699_89291850	0.16	ACAN	aggrecan	54900	0.13
chr21_32542516_32542707	0.16	TIAM1	T-cell lymphoma invasion and metastasis 1	40072	0.2
chr11_73703011_73703336	0.16	UCP2	uncoupling protein 2 (mitochondrial, proton carrier)	8821	0.14
chr4_4527024_4527175	0.16	STX18	syntaxin 18	16638	0.19
chr3_107697956_107698544	0.16	CD47	CD47 molecule	78958	0.11
chr19_10907600_10907797	0.16	DNM2	dynamin 2	14006	0.11
chr3_39097219_39097413	0.16	WDR48	WD repeat domain 48	3524	0.22
chr1_172596450_172596686	0.16	ENSG00000251943	.	13894	0.22
chr15_66180485_66180674	0.16	RAB11A	RAB11A, member RAS oncogene family	18228	0.19
chr2_106764772_106764923	0.16	UXS1	UDP-glucuronate decarboxylase 1	9510	0.24
chr6_90984611_90985132	0.16	BACH2	BTB and CNC homology 1, basic leucine zipper transcription factor 2	21590	0.23
chr5_133461389_133462125	0.16	TCF7	transcription factor 7 (T-cell specific, HMG-box)	2448	0.32
chr13_109063951_109064142	0.16	ENSG00000223177	.	110367	0.07
chr16_82687221_82687547	0.16	CDH13	cadherin 13	26686	0.24
chr5_156654582_156654733	0.16	CTB-4E7.1		3267	0.17
chr7_25010877_25011323	0.16	OSBPL3	oxysterol binding protein-like 3	8660	0.28
chr1_90097018_90097733	0.16	RP5-1007M22.2		375	0.77
chr4_153001544_153001744	0.16	ENSG00000253077	.	108879	0.07
chr2_10932773_10932924	0.16	PDIA6	protein disulfide isomerase family A, member 6	20032	0.15
chr13_41179836_41180017	0.16	FOXO1	forkhead box O1	60808	0.12
chr8_128985763_128985919	0.16	ENSG00000221771	.	12962	0.17
chr4_78699105_78699256	0.16	CNOT6L	CCR4-NOT transcription complex, subunit 6-like	35554	0.2
chr1_26244524_26244798	0.16	ENSG00000266763	.	6421	0.1
chr16_89439218_89439616	0.16	RP1-168P16.2		39555	0.09
chr10_22902783_22903038	0.16	PIP4K2A	phosphatidylinositol-5-phosphate 4-kinase, type II, alpha	22268	0.26
chr2_173344934_173345085	0.16	ITGA6	integrin, alpha 6	7681	0.17
chr11_60771525_60771682	0.16	CD6	CD6 molecule	4403	0.16
chrX_100741471_100741622	0.15	ARMCX4	armadillo repeat containing, X-linked 4	1485	0.36
chr5_94128731_94129084	0.15	CTC-484P3.3		4413	0.33
chr12_40012898_40013049	0.15	ABCD2	ATP-binding cassette, sub-family D (ALD), member 2	580	0.8
chr2_196362777_196363039	0.15	ENSG00000202206	.	15852	0.28
chr15_38952426_38952824	0.15	C15orf53	chromosome 15 open reading frame 53	36174	0.2
chr15_100871192_100871429	0.15	ADAMTS17	ADAM metallopeptidase with thrombospondin type 1 motif, 17	10031	0.24
chr18_13279580_13279786	0.15	LDLRAD4	low density lipoprotein receptor class A domain containing 4	1581	0.41
chr17_33858202_33858453	0.15	SLFN12L	schlafen family member 12-like	6553	0.12
chr4_99527732_99527883	0.15	TSPAN5	tetraspanin 5	50979	0.14
chr5_55980764_55981004	0.15	AC022431.2	Homo sapiens uncharacterized LOC101928448 (LOC101928448), mRNA.	78825	0.09
chr10_116570599_116570815	0.15	FAM160B1	family with sequence similarity 160, member B1	10796	0.28
chr1_226315104_226315315	0.15	RP11-275I14.4		20495	0.17
chr6_34389800_34389951	0.15	RPS10	ribosomal protein S10	3123	0.2
chr5_110698785_110698936	0.15	CTC-499J9.1		60595	0.13
chr1_220414900_220415051	0.15	RAB3GAP2	RAB3 GTPase activating protein subunit 2 (non-catalytic)	30256	0.17
chr6_112154473_112154969	0.15	FYN	FYN oncogene related to SRC, FGR, YES	11426	0.28
chr7_129283202_129283353	0.15	NRF1	nuclear respiratory factor 1	13368	0.23
chr9_14314790_14315056	0.15	NFIB	nuclear factor I/B	342	0.89
chrX_122861651_122861826	0.15	THOC2	THO complex 2	5166	0.22
chr10_33418555_33418889	0.15	ENSG00000263576	.	31158	0.18
chr7_133168020_133168171	0.15	EXOC4	exocyst complex component 4	93121	0.1
chr17_64281240_64281609	0.15	PRKCA	protein kinase C, alpha	17520	0.17
chr7_30062802_30062953	0.15	FKBP14	FK506 binding protein 14, 22 kDa	3423	0.19
chr14_103272684_103272835	0.15	ENSG00000238853	.	16831	0.16
chr1_31527232_31527567	0.15	PUM1	pumilio RNA-binding family member 1	7364	0.24
chr5_133425812_133426164	0.15	TCF7	transcription factor 7 (T-cell specific, HMG-box)	24414	0.2
chr6_119018462_119018613	0.15	CEP85L	centrosomal protein 85kDa-like	12694	0.29
chr2_204602129_204602280	0.15	ENSG00000211573	.	27317	0.18
chr2_109449874_109450025	0.15	CCDC138	coiled-coil domain containing 138	23435	0.24
chr21_29977737_29977955	0.15	ENSG00000251894	.	137684	0.05
chr17_74183944_74184095	0.15	RNF157	ring finger protein 157	20856	0.12
chr2_106781629_106781967	0.15	UXS1	UDP-glucuronate decarboxylase 1	4717	0.26
chr6_167530355_167530546	0.15	CCR6	chemokine (C-C motif) receptor 6	5155	0.21
chr14_99689884_99690335	0.15	AL109767.1		39176	0.16
chr2_148257449_148257801	0.15	ENSG00000202074	.	4517	0.24
chr2_225745980_225746131	0.15	DOCK10	dedicator of cytokinesis 10	64686	0.15
chr11_60860054_60860213	0.15	CD5	CD5 molecule	9734	0.18
chr4_2908083_2908378	0.15	ADD1	adducin 1 (alpha)	1327	0.4
chr22_31673029_31673483	0.15	PIK3IP1	phosphoinositide-3-kinase interacting protein 1	15125	0.1
chr11_118181943_118182094	0.15	CD3E	CD3e molecule, epsilon (CD3-TCR complex)	6404	0.13
chr1_160536888_160537098	0.15	CD84	CD84 molecule	12270	0.13
chr11_101983166_101983317	0.15	YAP1	Yes-associated protein 1	4	0.97
chr3_114884481_114884640	0.15	ZBTB20	zinc finger and BTB domain containing 20	18442	0.3
chr5_297425_297576	0.15	AHRR	aryl-hydrocarbon receptor repressor	6791	0.16
chr10_33376538_33376689	0.15	ENSG00000263576	.	10951	0.24
chr6_135339081_135339241	0.15	HBS1L	HBS1-like (S. cerevisiae)	9133	0.22
chr21_33033942_33034186	0.15	SOD1	superoxide dismutase 1, soluble	2085	0.26
chr19_19930368_19930519	0.15	ZNF506	zinc finger protein 506	2058	0.25
chr6_56959861_56960012	0.15	ZNF451	zinc finger protein 451	4931	0.23
chr3_27517558_27517709	0.15	SLC4A7	solute carrier family 4, sodium bicarbonate cotransporter, member 7	8205	0.21
chr19_47693979_47694272	0.15	ENSG00000265134	.	36074	0.11

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of NFATC2_NFATC3

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.5	GO:0033152	immunoglobulin V(D)J recombination(GO:0033152)
0.1	0.5	GO:0032656	regulation of interleukin-13 production(GO:0032656)
0.1	0.5	GO:0045589	regulation of regulatory T cell differentiation(GO:0045589)
0.1	0.4	GO:0001911	negative regulation of leukocyte mediated cytotoxicity(GO:0001911)
0.1	0.3	GO:0045066	regulatory T cell differentiation(GO:0045066)
0.1	0.3	GO:0050862	positive regulation of T cell receptor signaling pathway(GO:0050862)
0.1	0.2	GO:0072217	negative regulation of metanephros development(GO:0072217)
0.1	0.1	GO:0002326	B cell lineage commitment(GO:0002326)
0.1	0.1	GO:0043368	positive T cell selection(GO:0043368)
0.1	0.4	GO:0070670	response to interleukin-4(GO:0070670)
0.1	0.2	GO:0010761	fibroblast migration(GO:0010761)
0.1	0.1	GO:0002335	mature B cell differentiation involved in immune response(GO:0002313) mature B cell differentiation(GO:0002335)
0.1	0.2	GO:0048388	endosomal lumen acidification(GO:0048388)
0.1	0.1	GO:0010766	negative regulation of sodium ion transport(GO:0010766)
0.1	0.2	GO:0046719	intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) regulation by virus of viral protein levels in host cell(GO:0046719) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708)
0.1	0.2	GO:0060242	contact inhibition(GO:0060242)
0.1	0.2	GO:0060088	auditory receptor cell morphogenesis(GO:0002093) auditory receptor cell stereocilium organization(GO:0060088)
0.1	0.1	GO:0042091	interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.1	0.1	GO:0002890	negative regulation of B cell mediated immunity(GO:0002713) negative regulation of immunoglobulin mediated immune response(GO:0002890)
0.1	0.2	GO:0070602	centromeric sister chromatid cohesion(GO:0070601) regulation of centromeric sister chromatid cohesion(GO:0070602)
0.1	0.2	GO:0002870	lymphocyte anergy(GO:0002249) regulation of T cell anergy(GO:0002667) positive regulation of T cell anergy(GO:0002669) T cell anergy(GO:0002870) regulation of lymphocyte anergy(GO:0002911) positive regulation of lymphocyte anergy(GO:0002913)
0.1	0.2	GO:0034392	negative regulation of smooth muscle cell apoptotic process(GO:0034392)
0.1	0.3	GO:0007256	activation of JNKK activity(GO:0007256)
0.1	0.2	GO:0045722	positive regulation of gluconeogenesis(GO:0045722)
0.1	0.2	GO:0017182	peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.1	0.1	GO:0032071	regulation of endodeoxyribonuclease activity(GO:0032071)
0.1	0.4	GO:0033631	cell-cell adhesion mediated by integrin(GO:0033631)
0.0	0.4	GO:0030206	chondroitin sulfate biosynthetic process(GO:0030206)
0.0	0.2	GO:0019885	antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.0	0.2	GO:0050847	progesterone receptor signaling pathway(GO:0050847)
0.0	0.1	GO:0072161	mesenchymal cell differentiation involved in kidney development(GO:0072161) metanephric mesenchymal cell differentiation(GO:0072162) mesenchymal cell differentiation involved in renal system development(GO:2001012)
0.0	0.1	GO:0051834	evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.0	0.1	GO:0010459	negative regulation of heart rate(GO:0010459)
0.0	0.3	GO:0048013	ephrin receptor signaling pathway(GO:0048013)
0.0	0.1	GO:0051573	negative regulation of histone H3-K9 methylation(GO:0051573)
0.0	0.1	GO:0031580	membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.0	0.1	GO:0006772	thiamine metabolic process(GO:0006772)
0.0	0.1	GO:0070779	D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0	1.1	GO:0050690	regulation of defense response to virus by virus(GO:0050690)
0.0	0.2	GO:0045059	positive thymic T cell selection(GO:0045059)
0.0	0.2	GO:0042989	sequestering of actin monomers(GO:0042989)
0.0	0.2	GO:0002726	positive regulation of T cell cytokine production(GO:0002726)
0.0	0.1	GO:0002677	negative regulation of chronic inflammatory response(GO:0002677)
0.0	0.3	GO:0007172	signal complex assembly(GO:0007172)
0.0	0.1	GO:0031061	negative regulation of histone methylation(GO:0031061)
0.0	0.1	GO:0033173	calcineurin-NFAT signaling cascade(GO:0033173)
0.0	0.1	GO:0090292	nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0	0.2	GO:0022614	membrane to membrane docking(GO:0022614)
0.0	0.2	GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518) negative regulation of signal transduction by p53 class mediator(GO:1901797)
0.0	0.1	GO:0002693	positive regulation of cellular extravasation(GO:0002693)
0.0	0.1	GO:0046101	hypoxanthine biosynthetic process(GO:0046101)
0.0	0.2	GO:0048096	chromatin-mediated maintenance of transcription(GO:0048096)
0.0	0.3	GO:0000381	regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0	0.1	GO:0072224	metanephric glomerulus development(GO:0072224) metanephric glomerulus vasculature development(GO:0072239)
0.0	0.3	GO:0051489	regulation of filopodium assembly(GO:0051489)
0.0	0.0	GO:0061154	endothelial tube morphogenesis(GO:0061154)
0.0	0.1	GO:0015801	aromatic amino acid transport(GO:0015801)
0.0	0.1	GO:0010957	negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137)
0.0	0.1	GO:0006642	triglyceride mobilization(GO:0006642)
0.0	0.1	GO:0090116	DNA methylation on cytosine(GO:0032776) C-5 methylation of cytosine(GO:0090116)
0.0	0.2	GO:0000132	establishment of mitotic spindle orientation(GO:0000132) establishment of spindle orientation(GO:0051294)
0.0	0.1	GO:0002820	negative regulation of adaptive immune response(GO:0002820) negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains(GO:0002823)
0.0	0.0	GO:0030011	maintenance of cell polarity(GO:0030011)
0.0	0.2	GO:0002360	T cell lineage commitment(GO:0002360)
0.0	0.2	GO:0045898	regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0	0.0	GO:0060523	prostate epithelial cord elongation(GO:0060523)
0.0	0.1	GO:0043615	astrocyte cell migration(GO:0043615)
0.0	0.1	GO:0016115	diterpenoid catabolic process(GO:0016103) terpenoid catabolic process(GO:0016115) retinoic acid catabolic process(GO:0034653)
0.0	0.0	GO:0010216	maintenance of DNA methylation(GO:0010216)
0.0	0.1	GO:1904035	endothelial cell apoptotic process(GO:0072577) epithelial cell apoptotic process(GO:1904019) regulation of epithelial cell apoptotic process(GO:1904035) regulation of endothelial cell apoptotic process(GO:2000351)
0.0	0.1	GO:0042118	endothelial cell activation(GO:0042118)
0.0	0.1	GO:0006924	activation-induced cell death of T cells(GO:0006924)
0.0	0.1	GO:0060666	dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.0	0.1	GO:0051182	coenzyme transport(GO:0051182)
0.0	0.1	GO:0006498	N-terminal protein lipidation(GO:0006498)
0.0	0.1	GO:0035511	oxidative DNA demethylation(GO:0035511)
0.0	0.1	GO:0010989	negative regulation of low-density lipoprotein particle clearance(GO:0010989)
0.0	0.1	GO:0060605	tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662)
0.0	0.1	GO:0019276	UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.0	0.3	GO:0035329	hippo signaling(GO:0035329)
0.0	0.1	GO:0006855	drug transmembrane transport(GO:0006855)
0.0	0.1	GO:0019731	antimicrobial humoral response(GO:0019730) antibacterial humoral response(GO:0019731)
0.0	0.1	GO:0045875	negative regulation of sister chromatid cohesion(GO:0045875)
0.0	0.2	GO:0009103	lipopolysaccharide biosynthetic process(GO:0009103)
0.0	0.4	GO:0016601	Rac protein signal transduction(GO:0016601)
0.0	0.1	GO:0071364	cellular response to epidermal growth factor stimulus(GO:0071364)
0.0	0.1	GO:0015803	branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820)
0.0	0.7	GO:0000188	inactivation of MAPK activity(GO:0000188)
0.0	0.1	GO:0010508	positive regulation of autophagy(GO:0010508)
0.0	0.1	GO:0001743	optic placode formation(GO:0001743)
0.0	0.2	GO:0032733	positive regulation of interleukin-10 production(GO:0032733)
0.0	0.1	GO:0003310	pancreatic A cell differentiation(GO:0003310)
0.0	0.0	GO:0051531	NFAT protein import into nucleus(GO:0051531) regulation of NFAT protein import into nucleus(GO:0051532)
0.0	0.1	GO:0018076	N-terminal peptidyl-lysine acetylation(GO:0018076)
0.0	0.0	GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway(GO:0007195)
0.0	0.1	GO:0000281	mitotic cytokinesis(GO:0000281)
0.0	0.1	GO:0048859	formation of anatomical boundary(GO:0048859)
0.0	0.1	GO:0002063	chondrocyte development(GO:0002063)
0.0	0.0	GO:0006925	inflammatory cell apoptotic process(GO:0006925)
0.0	0.1	GO:0000733	DNA strand renaturation(GO:0000733)
0.0	0.1	GO:0034219	carbohydrate transmembrane transport(GO:0034219)
0.0	0.0	GO:0010511	regulation of phosphatidylinositol biosynthetic process(GO:0010511)
0.0	0.1	GO:0060049	regulation of protein glycosylation(GO:0060049)
0.0	0.1	GO:0002858	natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002420) natural killer cell mediated immune response to tumor cell(GO:0002423) positive regulation of response to biotic stimulus(GO:0002833) regulation of response to tumor cell(GO:0002834) positive regulation of response to tumor cell(GO:0002836) regulation of immune response to tumor cell(GO:0002837) positive regulation of immune response to tumor cell(GO:0002839) regulation of natural killer cell mediated immune response to tumor cell(GO:0002855) positive regulation of natural killer cell mediated immune response to tumor cell(GO:0002857) regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002858) positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002860)
0.0	0.1	GO:0070234	positive regulation of T cell apoptotic process(GO:0070234)
0.0	0.1	GO:0051653	establishment of spindle localization(GO:0051293) spindle localization(GO:0051653)
0.0	0.0	GO:0006290	pyrimidine dimer repair(GO:0006290)
0.0	0.2	GO:0008635	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c(GO:0008635)
0.0	0.1	GO:0034625	fatty acid elongation, monounsaturated fatty acid(GO:0034625)
0.0	0.1	GO:0090322	regulation of superoxide metabolic process(GO:0090322)
0.0	0.0	GO:0006883	cellular sodium ion homeostasis(GO:0006883)
0.0	0.1	GO:0060340	positive regulation of type I interferon-mediated signaling pathway(GO:0060340)
0.0	0.1	GO:0048149	behavioral response to ethanol(GO:0048149)
0.0	0.0	GO:1901419	regulation of response to alcohol(GO:1901419)
0.0	0.0	GO:0048319	axial mesoderm morphogenesis(GO:0048319)
0.0	0.1	GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.0	0.1	GO:0022417	protein maturation by protein folding(GO:0022417)
0.0	0.1	GO:0009138	pyrimidine nucleoside diphosphate metabolic process(GO:0009138)
0.0	0.1	GO:0006167	AMP biosynthetic process(GO:0006167)
0.0	0.1	GO:0010834	obsolete telomere maintenance via telomere shortening(GO:0010834)
0.0	0.1	GO:0035426	extracellular matrix-cell signaling(GO:0035426)
0.0	0.0	GO:0036072	intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.0	0.0	GO:0048537	mucosal-associated lymphoid tissue development(GO:0048537)
0.0	0.1	GO:0010867	positive regulation of triglyceride biosynthetic process(GO:0010867)
0.0	0.0	GO:1904406	negative regulation of nitric oxide biosynthetic process(GO:0045019) negative regulation of reactive oxygen species biosynthetic process(GO:1903427) negative regulation of nitric oxide metabolic process(GO:1904406)
0.0	0.1	GO:0097576	vacuole fusion(GO:0097576)
0.0	0.1	GO:0006538	glutamate catabolic process(GO:0006538)
0.0	0.1	GO:0000491	small nucleolar ribonucleoprotein complex assembly(GO:0000491) box C/D snoRNP assembly(GO:0000492)
0.0	0.2	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity(GO:0045197)
0.0	0.1	GO:0051085	chaperone mediated protein folding requiring cofactor(GO:0051085)
0.0	0.1	GO:0070172	positive regulation of tooth mineralization(GO:0070172)
0.0	0.1	GO:0016081	synaptic vesicle docking(GO:0016081)
0.0	0.1	GO:0015015	heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0	0.0	GO:0043983	histone H4-K12 acetylation(GO:0043983)
0.0	0.0	GO:0046642	negative regulation of alpha-beta T cell proliferation(GO:0046642)
0.0	0.0	GO:0002513	tolerance induction to self antigen(GO:0002513)
0.0	0.1	GO:0043267	negative regulation of potassium ion transport(GO:0043267)
0.0	0.1	GO:0007063	regulation of sister chromatid cohesion(GO:0007063)
0.0	0.1	GO:0060413	atrial septum development(GO:0003283) atrial septum morphogenesis(GO:0060413)
0.0	0.2	GO:0032456	endocytic recycling(GO:0032456)
0.0	0.2	GO:0071108	protein K48-linked deubiquitination(GO:0071108)
0.0	0.0	GO:0016242	regulation of macroautophagy(GO:0016241) negative regulation of macroautophagy(GO:0016242)
0.0	0.1	GO:0045906	negative regulation of vasoconstriction(GO:0045906)
0.0	0.2	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0	0.2	GO:0019059	obsolete initiation of viral infection(GO:0019059)
0.0	0.1	GO:0006931	substrate-dependent cell migration, cell attachment to substrate(GO:0006931)
0.0	0.0	GO:0048289	isotype switching to IgE isotypes(GO:0048289) regulation of isotype switching to IgE isotypes(GO:0048293)
0.0	0.1	GO:0033015	porphyrin-containing compound catabolic process(GO:0006787) tetrapyrrole catabolic process(GO:0033015) heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149)
0.0	0.1	GO:0042996	regulation of Golgi to plasma membrane protein transport(GO:0042996)
0.0	0.1	GO:0031648	protein destabilization(GO:0031648)
0.0	0.0	GO:0032261	purine nucleotide salvage(GO:0032261)
0.0	0.1	GO:0000380	alternative mRNA splicing, via spliceosome(GO:0000380)
0.0	0.1	GO:0060648	mammary gland bud morphogenesis(GO:0060648)
0.0	0.1	GO:0070120	ciliary neurotrophic factor-mediated signaling pathway(GO:0070120)
0.0	0.1	GO:0015937	coenzyme A biosynthetic process(GO:0015937)
0.0	0.4	GO:0046677	response to antibiotic(GO:0046677)
0.0	0.1	GO:0014912	negative regulation of smooth muscle cell migration(GO:0014912)
0.0	0.0	GO:2000399	negative regulation of T cell differentiation in thymus(GO:0033085) negative regulation of thymocyte aggregation(GO:2000399)
0.0	0.1	GO:0019509	L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
0.0	0.1	GO:0035246	peptidyl-arginine N-methylation(GO:0035246)
0.0	0.2	GO:0001782	B cell homeostasis(GO:0001782)
0.0	0.0	GO:0051571	positive regulation of histone methylation(GO:0031062) positive regulation of histone H3-K4 methylation(GO:0051571)
0.0	0.1	GO:1901339	activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0	0.0	GO:1901021	positive regulation of calcium ion transmembrane transporter activity(GO:1901021) positive regulation of cation channel activity(GO:2001259)
0.0	0.1	GO:0051497	negative regulation of stress fiber assembly(GO:0051497)
0.0	0.0	GO:0048304	positive regulation of isotype switching to IgG isotypes(GO:0048304)
0.0	0.1	GO:0009301	snRNA transcription(GO:0009301)
0.0	0.1	GO:0044341	sodium-dependent phosphate transport(GO:0044341)
0.0	0.0	GO:0042415	norepinephrine metabolic process(GO:0042415)
0.0	0.1	GO:0006188	IMP biosynthetic process(GO:0006188) IMP metabolic process(GO:0046040)
0.0	0.1	GO:0006104	succinyl-CoA metabolic process(GO:0006104)
0.0	0.1	GO:0000470	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463) maturation of LSU-rRNA(GO:0000470)
0.0	0.0	GO:0090047	obsolete positive regulation of transcription regulator activity(GO:0090047)
0.0	0.2	GO:0021516	dorsal spinal cord development(GO:0021516)
0.0	0.1	GO:0031958	corticosteroid receptor signaling pathway(GO:0031958)
0.0	0.2	GO:1902749	regulation of G2/M transition of mitotic cell cycle(GO:0010389) regulation of cell cycle G2/M phase transition(GO:1902749)
0.0	0.0	GO:0046502	uroporphyrinogen III metabolic process(GO:0046502) cellular response to arsenic-containing substance(GO:0071243)
0.0	0.1	GO:0000089	mitotic metaphase(GO:0000089)
0.0	0.1	GO:0035414	negative regulation of catenin import into nucleus(GO:0035414)
0.0	0.1	GO:0045040	outer mitochondrial membrane organization(GO:0007008) protein import into mitochondrial outer membrane(GO:0045040)
0.0	0.0	GO:0032823	regulation of natural killer cell differentiation(GO:0032823) positive regulation of natural killer cell differentiation(GO:0032825)
0.0	0.1	GO:0051788	response to misfolded protein(GO:0051788)
0.0	0.0	GO:0036037	CD8-positive, alpha-beta T cell activation(GO:0036037) CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0	0.0	GO:0000212	meiotic spindle organization(GO:0000212)
0.0	0.0	GO:0032730	regulation of interleukin-1 alpha production(GO:0032650) positive regulation of interleukin-1 alpha production(GO:0032730)
0.0	0.0	GO:0060081	membrane hyperpolarization(GO:0060081)
0.0	0.0	GO:0051938	L-glutamate import(GO:0051938)
0.0	0.1	GO:0006491	N-glycan processing(GO:0006491)
0.0	0.1	GO:0008298	intracellular mRNA localization(GO:0008298)
0.0	0.1	GO:0090399	replicative senescence(GO:0090399)
0.0	0.1	GO:0016553	base conversion or substitution editing(GO:0016553)
0.0	0.1	GO:0006658	phosphatidylserine metabolic process(GO:0006658)
0.0	0.0	GO:0042420	dopamine catabolic process(GO:0042420)
0.0	0.0	GO:0035025	positive regulation of Rho protein signal transduction(GO:0035025)
0.0	0.0	GO:0001831	trophectodermal cellular morphogenesis(GO:0001831)
0.0	0.0	GO:0071542	dopaminergic neuron differentiation(GO:0071542)
0.0	0.1	GO:0018345	protein palmitoylation(GO:0018345)
0.0	0.3	GO:0000718	nucleotide-excision repair, DNA damage removal(GO:0000718) DNA excision(GO:0044349)
0.0	0.2	GO:0006688	glycosphingolipid biosynthetic process(GO:0006688)
0.0	0.1	GO:0009886	post-embryonic morphogenesis(GO:0009886)
0.0	0.1	GO:0045008	depyrimidination(GO:0045008)
0.0	0.0	GO:0071803	regulation of podosome assembly(GO:0071801) positive regulation of podosome assembly(GO:0071803)
0.0	0.0	GO:0021853	interneuron migration from the subpallium to the cortex(GO:0021830) cerebral cortex GABAergic interneuron migration(GO:0021853) cerebral cortex GABAergic interneuron development(GO:0021894) interneuron migration(GO:1904936)
0.0	0.0	GO:0008049	male courtship behavior(GO:0008049)
0.0	0.0	GO:0010882	regulation of cardiac muscle contraction by calcium ion signaling(GO:0010882)
0.0	0.0	GO:0021913	regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913)
0.0	0.1	GO:0042987	amyloid precursor protein catabolic process(GO:0042987)
0.0	0.1	GO:0007520	syncytium formation by plasma membrane fusion(GO:0000768) syncytium formation(GO:0006949) myoblast fusion(GO:0007520)
0.0	0.0	GO:0015904	tetracycline transport(GO:0015904)
0.0	0.0	GO:0006384	transcription initiation from RNA polymerase III promoter(GO:0006384)
0.0	0.0	GO:0032966	negative regulation of collagen biosynthetic process(GO:0032966)
0.0	0.0	GO:0046322	negative regulation of fatty acid oxidation(GO:0046322)
0.0	0.2	GO:0007076	mitotic chromosome condensation(GO:0007076)
0.0	0.0	GO:1902101	positive regulation of mitotic metaphase/anaphase transition(GO:0045842) chromosome movement towards spindle pole(GO:0051305) positive regulation of mitotic sister chromatid separation(GO:1901970) positive regulation of metaphase/anaphase transition of cell cycle(GO:1902101)
0.0	0.1	GO:0002921	negative regulation of humoral immune response(GO:0002921) negative regulation of complement activation(GO:0045916) negative regulation of protein activation cascade(GO:2000258)
0.0	0.1	GO:0060037	pharyngeal system development(GO:0060037)
0.0	0.0	GO:0046877	regulation of saliva secretion(GO:0046877)
0.0	0.0	GO:0021827	cerebral cortex tangential migration using cell-cell interactions(GO:0021823) substrate-dependent cerebral cortex tangential migration(GO:0021825) postnatal olfactory bulb interneuron migration(GO:0021827)
0.0	0.6	GO:0031295	lymphocyte costimulation(GO:0031294) T cell costimulation(GO:0031295)
0.0	0.0	GO:0045046	protein import into peroxisome membrane(GO:0045046)
0.0	0.0	GO:0051045	negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
0.0	0.2	GO:0000305	response to oxygen radical(GO:0000305)
0.0	0.0	GO:0050689	negative regulation of defense response to virus by host(GO:0050689)
0.0	0.1	GO:0071674	positive regulation of macrophage chemotaxis(GO:0010759) mononuclear cell migration(GO:0071674) regulation of mononuclear cell migration(GO:0071675)
0.0	0.1	GO:0055026	negative regulation of cardiac muscle tissue growth(GO:0055022) negative regulation of cardiac muscle tissue development(GO:0055026) negative regulation of cardiac muscle cell proliferation(GO:0060044) negative regulation of heart growth(GO:0061117)
0.0	0.0	GO:0006562	proline catabolic process(GO:0006562)
0.0	0.0	GO:0031946	regulation of glucocorticoid biosynthetic process(GO:0031946)
0.0	0.0	GO:0061004	pattern specification involved in kidney development(GO:0061004) renal system pattern specification(GO:0072048) pattern specification involved in metanephros development(GO:0072268)
0.0	0.1	GO:0048208	vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208) COPII-coated vesicle budding(GO:0090114)
0.0	0.0	GO:0055078	sodium ion homeostasis(GO:0055078)
0.0	0.1	GO:0070534	protein K63-linked ubiquitination(GO:0070534)
0.0	0.1	GO:0007023	post-chaperonin tubulin folding pathway(GO:0007023)
0.0	0.0	GO:0018094	protein polyglycylation(GO:0018094)
0.0	0.2	GO:0034199	activation of protein kinase A activity(GO:0034199)
0.0	0.1	GO:0046688	response to copper ion(GO:0046688)
0.0	0.0	GO:0060737	prostate gland morphogenetic growth(GO:0060737)
0.0	0.0	GO:0030186	melatonin metabolic process(GO:0030186) melatonin biosynthetic process(GO:0030187)
0.0	0.3	GO:0050772	positive regulation of axonogenesis(GO:0050772)
0.0	0.0	GO:0045064	T-helper 2 cell differentiation(GO:0045064) regulation of T-helper 2 cell differentiation(GO:0045628)
0.0	0.1	GO:0016255	attachment of GPI anchor to protein(GO:0016255)
0.0	0.1	GO:0006451	selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.0	0.1	GO:0008089	anterograde axonal transport(GO:0008089)
0.0	0.1	GO:0051383	kinetochore organization(GO:0051383)
0.0	0.1	GO:0048069	eye pigmentation(GO:0048069)
0.0	0.0	GO:0010866	regulation of triglyceride biosynthetic process(GO:0010866)
0.0	0.0	GO:0042109	lymphotoxin A production(GO:0032641) lymphotoxin A biosynthetic process(GO:0042109)
0.0	0.1	GO:0021561	facial nerve development(GO:0021561)
0.0	0.0	GO:0045581	negative regulation of T cell differentiation(GO:0045581)
0.0	0.2	GO:0042776	mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.0	0.0	GO:0010738	regulation of protein kinase A signaling(GO:0010738)
0.0	0.0	GO:0014834	skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration(GO:0014834)
0.0	0.0	GO:0033683	nucleotide-excision repair, DNA incision(GO:0033683)
0.0	0.0	GO:0071681	response to indole-3-methanol(GO:0071680) cellular response to indole-3-methanol(GO:0071681)
0.0	0.0	GO:0090205	positive regulation of cholesterol metabolic process(GO:0090205)
0.0	0.0	GO:0048617	embryonic foregut morphogenesis(GO:0048617)
0.0	0.1	GO:0043984	histone H4-K16 acetylation(GO:0043984)
0.0	0.1	GO:0046856	phosphatidylinositol dephosphorylation(GO:0046856)
0.0	0.0	GO:2000758	positive regulation of histone acetylation(GO:0035066) positive regulation of protein acetylation(GO:1901985) positive regulation of peptidyl-lysine acetylation(GO:2000758)
0.0	0.3	GO:0000289	nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.0	0.0	GO:0060972	left/right pattern formation(GO:0060972)
0.0	0.1	GO:0007016	cytoskeletal anchoring at plasma membrane(GO:0007016)
0.0	0.1	GO:0085020	protein K6-linked ubiquitination(GO:0085020)
0.0	0.1	GO:0061077	chaperone-mediated protein folding(GO:0061077)
0.0	0.1	GO:0015671	oxygen transport(GO:0015671)
0.0	0.1	GO:0061099	negative regulation of protein tyrosine kinase activity(GO:0061099)
0.0	0.0	GO:0032808	lacrimal gland development(GO:0032808)
0.0	0.5	GO:0060333	interferon-gamma-mediated signaling pathway(GO:0060333)
0.0	0.0	GO:0021860	pyramidal neuron differentiation(GO:0021859) pyramidal neuron development(GO:0021860)
0.0	0.1	GO:0018027	peptidyl-lysine dimethylation(GO:0018027)
0.0	0.0	GO:0010831	positive regulation of myotube differentiation(GO:0010831)
0.0	0.0	GO:0006678	glucosylceramide metabolic process(GO:0006678)
0.0	0.0	GO:0070208	protein heterotrimerization(GO:0070208)
0.0	0.0	GO:0015917	aminophospholipid transport(GO:0015917)
0.0	0.1	GO:0016226	iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.0	0.1	GO:0006553	lysine metabolic process(GO:0006553) lysine catabolic process(GO:0006554)
0.0	0.0	GO:0010457	centriole-centriole cohesion(GO:0010457)
0.0	0.1	GO:0006600	creatine metabolic process(GO:0006600)
0.0	0.0	GO:0009113	purine nucleobase biosynthetic process(GO:0009113)
0.0	0.0	GO:0008588	release of cytoplasmic sequestered NF-kappaB(GO:0008588)
0.0	0.0	GO:0003214	cardiac left ventricle morphogenesis(GO:0003214)
0.0	0.0	GO:0006089	lactate metabolic process(GO:0006089)
0.0	0.1	GO:0007379	segment specification(GO:0007379)
0.0	0.0	GO:0006515	misfolded or incompletely synthesized protein catabolic process(GO:0006515)
0.0	0.1	GO:0001662	behavioral fear response(GO:0001662)
0.0	0.0	GO:0016139	glycoside metabolic process(GO:0016137) glycoside catabolic process(GO:0016139)
0.0	0.1	GO:0045948	positive regulation of translational initiation(GO:0045948)
0.0	0.0	GO:0061339	establishment of apical/basal cell polarity(GO:0035089) establishment of monopolar cell polarity(GO:0061162) establishment or maintenance of monopolar cell polarity(GO:0061339)
0.0	0.1	GO:0046655	folic acid metabolic process(GO:0046655)
0.0	0.1	GO:0032324	Mo-molybdopterin cofactor biosynthetic process(GO:0006777) Mo-molybdopterin cofactor metabolic process(GO:0019720) molybdopterin cofactor biosynthetic process(GO:0032324) molybdopterin cofactor metabolic process(GO:0043545) prosthetic group metabolic process(GO:0051189)
0.0	0.1	GO:0060124	positive regulation of growth hormone secretion(GO:0060124)
0.0	0.0	GO:2000114	regulation of establishment of cell polarity(GO:2000114)
0.0	0.1	GO:0018126	protein hydroxylation(GO:0018126)
0.0	0.1	GO:0046784	viral mRNA export from host cell nucleus(GO:0046784)
0.0	0.1	GO:0006337	nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.0	0.0	GO:0046831	regulation of RNA export from nucleus(GO:0046831)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0042105	alpha-beta T cell receptor complex(GO:0042105)
0.1	0.2	GO:0031235	intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.1	0.2	GO:0005954	calcium- and calmodulin-dependent protein kinase complex(GO:0005954)
0.1	0.2	GO:0000942	condensed nuclear chromosome outer kinetochore(GO:0000942)
0.0	0.1	GO:0001940	male pronucleus(GO:0001940)
0.0	0.5	GO:0010494	cytoplasmic stress granule(GO:0010494)
0.0	0.1	GO:0005896	interleukin-6 receptor complex(GO:0005896)
0.0	0.4	GO:0035631	CD40 receptor complex(GO:0035631)
0.0	0.1	GO:0014731	spectrin-associated cytoskeleton(GO:0014731)
0.0	0.1	GO:0032449	CBM complex(GO:0032449)
0.0	0.1	GO:0071942	XPC complex(GO:0071942)
0.0	0.2	GO:0005797	Golgi medial cisterna(GO:0005797)
0.0	0.2	GO:0042589	zymogen granule membrane(GO:0042589)
0.0	0.1	GO:0016942	insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454)
0.0	0.1	GO:0032444	activin responsive factor complex(GO:0032444)
0.0	0.1	GO:0038201	TOR complex(GO:0038201)
0.0	0.0	GO:0071564	npBAF complex(GO:0071564)
0.0	0.2	GO:0043190	ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.0	0.1	GO:0005863	striated muscle myosin thick filament(GO:0005863)
0.0	0.2	GO:0000791	euchromatin(GO:0000791)
0.0	0.1	GO:0000300	obsolete peripheral to membrane of membrane fraction(GO:0000300)
0.0	0.3	GO:0001772	immunological synapse(GO:0001772)
0.0	0.2	GO:0001891	phagocytic cup(GO:0001891)
0.0	0.1	GO:0030891	VCB complex(GO:0030891)
0.0	0.1	GO:0001652	granular component(GO:0001652)
0.0	0.1	GO:0072669	tRNA-splicing ligase complex(GO:0072669)
0.0	0.3	GO:0016514	SWI/SNF complex(GO:0016514)
0.0	0.1	GO:0030056	hemidesmosome(GO:0030056)
0.0	0.4	GO:0000159	protein phosphatase type 2A complex(GO:0000159)
0.0	0.3	GO:0045334	clathrin-coated endocytic vesicle(GO:0045334)
0.0	0.1	GO:0098647	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0	0.1	GO:0048179	activin receptor complex(GO:0048179)
0.0	0.1	GO:0005850	eukaryotic translation initiation factor 2 complex(GO:0005850)
0.0	0.1	GO:0031254	uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0	0.1	GO:0000796	condensin complex(GO:0000796)
0.0	0.1	GO:0072487	MSL complex(GO:0072487)
0.0	0.3	GO:0071203	WASH complex(GO:0071203)
0.0	0.1	GO:0008091	spectrin(GO:0008091)
0.0	0.3	GO:0005942	phosphatidylinositol 3-kinase complex(GO:0005942)
0.0	0.2	GO:0030877	beta-catenin destruction complex(GO:0030877)
0.0	0.1	GO:0071438	invadopodium membrane(GO:0071438)
0.0	0.2	GO:0016342	catenin complex(GO:0016342)
0.0	0.1	GO:0005883	neurofilament(GO:0005883)
0.0	0.1	GO:0031371	ubiquitin conjugating enzyme complex(GO:0031371)
0.0	0.1	GO:0000138	Golgi trans cisterna(GO:0000138)
0.0	0.1	GO:0031229	integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.0	0.1	GO:0031265	CD95 death-inducing signaling complex(GO:0031265)
0.0	0.2	GO:0008278	cohesin complex(GO:0008278)
0.0	0.1	GO:0070545	PeBoW complex(GO:0070545)
0.0	0.1	GO:0034045	pre-autophagosomal structure membrane(GO:0034045)
0.0	0.1	GO:0033256	I-kappaB/NF-kappaB complex(GO:0033256)
0.0	0.1	GO:0070775	H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0	0.1	GO:0070761	pre-snoRNP complex(GO:0070761)
0.0	0.0	GO:0000506	glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0	0.1	GO:0032839	dendrite cytoplasm(GO:0032839)
0.0	0.2	GO:0031105	septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.0	0.1	GO:0070688	MLL5-L complex(GO:0070688)
0.0	0.1	GO:0005662	DNA replication factor A complex(GO:0005662)
0.0	0.0	GO:0001939	female pronucleus(GO:0001939)
0.0	0.2	GO:0030914	STAGA complex(GO:0030914)
0.0	0.1	GO:0005606	laminin-1 complex(GO:0005606)
0.0	0.1	GO:0005655	nucleolar ribonuclease P complex(GO:0005655) ribonuclease P complex(GO:0030677) multimeric ribonuclease P complex(GO:0030681)
0.0	0.1	GO:0017146	NMDA selective glutamate receptor complex(GO:0017146)
0.0	0.0	GO:0005588	collagen type V trimer(GO:0005588)
0.0	0.1	GO:0045120	pronucleus(GO:0045120)
0.0	0.1	GO:0042101	T cell receptor complex(GO:0042101)
0.0	0.1	GO:0032590	dendrite membrane(GO:0032590)
0.0	0.1	GO:0000276	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0	0.0	GO:0034673	inhibin-betaglycan-ActRII complex(GO:0034673)
0.0	0.3	GO:0000932	cytoplasmic mRNA processing body(GO:0000932)
0.0	0.8	GO:0032580	Golgi cisterna membrane(GO:0032580)
0.0	0.4	GO:0032587	ruffle membrane(GO:0032587)
0.0	0.0	GO:0070022	transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0	0.1	GO:0005666	DNA-directed RNA polymerase III complex(GO:0005666)
0.0	0.1	GO:0005697	telomerase holoenzyme complex(GO:0005697)
0.0	0.0	GO:0090544	BAF-type complex(GO:0090544)
0.0	0.3	GO:0019005	SCF ubiquitin ligase complex(GO:0019005)
0.0	0.0	GO:0031428	box C/D snoRNP complex(GO:0031428)
0.0	0.1	GO:0042765	GPI-anchor transamidase complex(GO:0042765)
0.0	0.3	GO:0005637	nuclear inner membrane(GO:0005637)
0.0	0.2	GO:0031519	PcG protein complex(GO:0031519)
0.0	0.0	GO:0016939	kinesin II complex(GO:0016939)
0.0	0.0	GO:0033150	cytoskeletal calyx(GO:0033150)
0.0	0.1	GO:0090576	RNA polymerase III transcription factor complex(GO:0090576)
0.0	0.1	GO:0005852	eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0	0.1	GO:0019907	cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
0.0	0.1	GO:0008385	IkappaB kinase complex(GO:0008385)
0.0	0.1	GO:0000242	pericentriolar material(GO:0000242)
0.0	0.0	GO:0000137	Golgi cis cisterna(GO:0000137)
0.0	0.2	GO:0005892	acetylcholine-gated channel complex(GO:0005892)
0.0	0.0	GO:0033011	perinuclear theca(GO:0033011)
0.0	0.1	GO:0000346	transcription export complex(GO:0000346)
0.0	0.3	GO:0009295	nucleoid(GO:0009295)
0.0	0.1	GO:0034451	centriolar satellite(GO:0034451)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0030284	estrogen receptor activity(GO:0030284)
0.1	0.2	GO:0003836	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.1	0.2	GO:0031628	opioid receptor binding(GO:0031628)
0.1	0.2	GO:0016309	1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.1	0.8	GO:0004697	protein kinase C activity(GO:0004697)
0.1	0.2	GO:0043125	ErbB-3 class receptor binding(GO:0043125)
0.1	0.5	GO:0016493	C-C chemokine receptor activity(GO:0016493)
0.0	0.1	GO:0005176	ErbB-2 class receptor binding(GO:0005176)
0.0	0.2	GO:0015925	galactosidase activity(GO:0015925)
0.0	0.1	GO:0045499	chemorepellent activity(GO:0045499)
0.0	0.2	GO:0055106	ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106)
0.0	0.4	GO:0034593	phosphatidylinositol bisphosphate phosphatase activity(GO:0034593)
0.0	0.2	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.0	0.2	GO:0030346	protein phosphatase 2B binding(GO:0030346)
0.0	0.2	GO:0005131	growth hormone receptor binding(GO:0005131)
0.0	0.1	GO:0008475	procollagen-lysine 5-dioxygenase activity(GO:0008475)
0.0	0.1	GO:0004591	oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.0	0.1	GO:0008510	sodium:bicarbonate symporter activity(GO:0008510)
0.0	0.4	GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0	0.3	GO:0005072	transforming growth factor beta receptor, cytoplasmic mediator activity(GO:0005072)
0.0	0.1	GO:0003726	double-stranded RNA adenosine deaminase activity(GO:0003726)
0.0	0.1	GO:0004897	ciliary neurotrophic factor receptor activity(GO:0004897)
0.0	0.2	GO:0008266	poly(U) RNA binding(GO:0008266)
0.0	0.1	GO:0003886	DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0	0.1	GO:0016842	amidine-lyase activity(GO:0016842)
0.0	0.2	GO:0016494	C-X-C chemokine receptor activity(GO:0016494)
0.0	0.3	GO:0046875	ephrin receptor binding(GO:0046875)
0.0	0.1	GO:0043008	ATP-dependent protein binding(GO:0043008)
0.0	0.1	GO:0035514	DNA demethylase activity(GO:0035514) DNA-N1-methyladenine dioxygenase activity(GO:0043734)
0.0	1.3	GO:0001948	glycoprotein binding(GO:0001948)
0.0	0.2	GO:0003828	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0	0.1	GO:0004090	carbonyl reductase (NADPH) activity(GO:0004090)
0.0	0.2	GO:0008494	translation activator activity(GO:0008494)
0.0	0.1	GO:0030899	calcium-dependent ATPase activity(GO:0030899)
0.0	0.1	GO:0000247	C-8 sterol isomerase activity(GO:0000247)
0.0	0.1	GO:0004594	pantothenate kinase activity(GO:0004594)
0.0	0.1	GO:0031013	troponin I binding(GO:0031013)
0.0	0.1	GO:0008545	JUN kinase kinase activity(GO:0008545)
0.0	0.1	GO:0005315	inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0	0.1	GO:0030292	protein tyrosine kinase inhibitor activity(GO:0030292)
0.0	0.1	GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.0	0.1	GO:0017162	aryl hydrocarbon receptor binding(GO:0017162)
0.0	0.1	GO:0005314	high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.0	0.2	GO:0004691	cAMP-dependent protein kinase activity(GO:0004691)
0.0	0.1	GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0	0.1	GO:0008140	cAMP response element binding protein binding(GO:0008140)
0.0	0.1	GO:0050698	proteoglycan sulfotransferase activity(GO:0050698)
0.0	0.1	GO:0016778	diphosphotransferase activity(GO:0016778)
0.0	0.4	GO:0030159	receptor signaling complex scaffold activity(GO:0030159)
0.0	0.1	GO:0004774	succinate-CoA ligase activity(GO:0004774)
0.0	0.0	GO:0005134	interleukin-2 receptor binding(GO:0005134)
0.0	0.1	GO:0004911	interleukin-2 receptor activity(GO:0004911)
0.0	0.2	GO:0030507	spectrin binding(GO:0030507)
0.0	0.1	GO:0004311	farnesyltranstransferase activity(GO:0004311)
0.0	0.2	GO:0015271	outward rectifier potassium channel activity(GO:0015271)
0.0	0.1	GO:0004517	nitric-oxide synthase activity(GO:0004517)
0.0	0.0	GO:0046975	histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.0	0.1	GO:0008401	retinoic acid 4-hydroxylase activity(GO:0008401)
0.0	0.0	GO:0043237	laminin-1 binding(GO:0043237)
0.0	0.1	GO:0043175	RNA polymerase core enzyme binding(GO:0043175)
0.0	0.4	GO:0043621	protein self-association(GO:0043621)
0.0	0.1	GO:0001601	peptide YY receptor activity(GO:0001601)
0.0	0.0	GO:0035241	protein-arginine omega-N monomethyltransferase activity(GO:0035241)
0.0	0.1	GO:0034452	dynactin binding(GO:0034452)
0.0	0.0	GO:0019958	C-X-C chemokine binding(GO:0019958) interleukin-8 binding(GO:0019959)
0.0	0.1	GO:0015355	secondary active monocarboxylate transmembrane transporter activity(GO:0015355)
0.0	0.3	GO:0005095	GTPase inhibitor activity(GO:0005095)
0.0	0.1	GO:0061630	ubiquitin-ubiquitin ligase activity(GO:0034450) ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659)
0.0	0.1	GO:0004862	cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0	0.4	GO:0008601	protein phosphatase type 2A regulator activity(GO:0008601)
0.0	0.3	GO:0031593	polyubiquitin binding(GO:0031593)
0.0	0.0	GO:0015421	oligopeptide-transporting ATPase activity(GO:0015421) peptide-transporting ATPase activity(GO:0015440)
0.0	0.1	GO:0019211	phosphatase activator activity(GO:0019211)
0.0	0.0	GO:0005025	transforming growth factor beta receptor activity, type I(GO:0005025)
0.0	0.1	GO:0031702	type 1 angiotensin receptor binding(GO:0031702)
0.0	0.1	GO:0004437	obsolete inositol or phosphatidylinositol phosphatase activity(GO:0004437)
0.0	0.2	GO:0048407	platelet-derived growth factor binding(GO:0048407)
0.0	0.1	GO:0050265	RNA uridylyltransferase activity(GO:0050265)
0.0	0.1	GO:0000739	obsolete DNA strand annealing activity(GO:0000739)
0.0	0.3	GO:0015026	coreceptor activity(GO:0015026)
0.0	0.1	GO:0070411	I-SMAD binding(GO:0070411)
0.0	0.1	GO:0005049	nuclear export signal receptor activity(GO:0005049)
0.0	0.0	GO:1990939	ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) ATP-dependent microtubule motor activity(GO:1990939)
0.0	0.1	GO:0015379	potassium:chloride symporter activity(GO:0015379)
0.0	0.2	GO:0051018	protein kinase A binding(GO:0051018)
0.0	0.1	GO:0005143	interleukin-12 receptor binding(GO:0005143)
0.0	0.1	GO:0036002	pre-mRNA binding(GO:0036002)
0.0	0.1	GO:0042043	neurexin family protein binding(GO:0042043)
0.0	0.1	GO:0004111	creatine kinase activity(GO:0004111)
0.0	0.1	GO:0001637	G-protein coupled chemoattractant receptor activity(GO:0001637) chemokine receptor activity(GO:0004950)
0.0	0.1	GO:0051998	carboxyl-O-methyltransferase activity(GO:0010340) protein carboxyl O-methyltransferase activity(GO:0051998)
0.0	0.1	GO:0016531	copper chaperone activity(GO:0016531)
0.0	0.1	GO:0052866	phosphatidylinositol phosphate phosphatase activity(GO:0052866)
0.0	0.1	GO:0005138	interleukin-6 receptor binding(GO:0005138)
0.0	0.3	GO:0005164	tumor necrosis factor receptor binding(GO:0005164)
0.0	0.3	GO:0004889	acetylcholine-activated cation-selective channel activity(GO:0004889)
0.0	0.3	GO:0005540	hyaluronic acid binding(GO:0005540)
0.0	0.1	GO:0051019	mitogen-activated protein kinase binding(GO:0051019)
0.0	0.0	GO:0004466	long-chain-acyl-CoA dehydrogenase activity(GO:0004466)
0.0	0.0	GO:0050815	phosphoserine binding(GO:0050815)
0.0	0.1	GO:0008440	inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440) inositol trisphosphate kinase activity(GO:0051766)
0.0	0.0	GO:0033691	sialic acid binding(GO:0033691)
0.0	0.4	GO:0003725	double-stranded RNA binding(GO:0003725)
0.0	0.1	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0	0.1	GO:0008967	phosphoglycolate phosphatase activity(GO:0008967)
0.0	0.1	GO:0017176	phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0	0.3	GO:0004683	calmodulin-dependent protein kinase activity(GO:0004683)
0.0	0.1	GO:0043495	protein anchor(GO:0043495)
0.0	0.0	GO:0016774	phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.0	0.4	GO:0016831	carboxy-lyase activity(GO:0016831)
0.0	0.1	GO:0008649	rRNA methyltransferase activity(GO:0008649)
0.0	0.2	GO:0070064	proline-rich region binding(GO:0070064)
0.0	0.1	GO:0035242	protein-arginine omega-N asymmetric methyltransferase activity(GO:0035242)
0.0	0.0	GO:0070815	peptidyl-lysine 5-dioxygenase activity(GO:0070815)
0.0	0.1	GO:0030229	very-low-density lipoprotein particle receptor activity(GO:0030229)
0.0	0.2	GO:0051010	microtubule plus-end binding(GO:0051010)
0.0	0.1	GO:0008568	microtubule-severing ATPase activity(GO:0008568)
0.0	0.1	GO:0005092	GDP-dissociation inhibitor activity(GO:0005092)
0.0	0.0	GO:0004967	glucagon receptor activity(GO:0004967)
0.0	0.0	GO:0043515	kinetochore binding(GO:0043515)
0.0	0.0	GO:0001733	galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694)
0.0	0.2	GO:0016922	ligand-dependent nuclear receptor binding(GO:0016922)
0.0	0.1	GO:0070410	co-SMAD binding(GO:0070410)
0.0	0.0	GO:0004607	phosphatidylcholine-sterol O-acyltransferase activity(GO:0004607)
0.0	0.1	GO:0048018	receptor agonist activity(GO:0048018)
0.0	0.0	GO:0034187	obsolete apolipoprotein E binding(GO:0034187)
0.0	0.0	GO:0016212	kynurenine-oxoglutarate transaminase activity(GO:0016212) kynurenine aminotransferase activity(GO:0036137)
0.0	0.0	GO:0004505	phenylalanine 4-monooxygenase activity(GO:0004505)
0.0	0.1	GO:0099604	calcium-release channel activity(GO:0015278) ligand-gated calcium channel activity(GO:0099604)
0.0	0.0	GO:0008174	mRNA methyltransferase activity(GO:0008174)
0.0	0.0	GO:0070735	protein-glycine ligase activity(GO:0070735)
0.0	0.1	GO:0017110	nucleoside-diphosphatase activity(GO:0017110)
0.0	0.0	GO:0000064	L-ornithine transmembrane transporter activity(GO:0000064)
0.0	0.0	GO:0004952	dopamine neurotransmitter receptor activity(GO:0004952)
0.0	0.0	GO:0000400	four-way junction DNA binding(GO:0000400)
0.0	0.0	GO:0031849	olfactory receptor binding(GO:0031849)
0.0	0.1	GO:0008239	dipeptidyl-peptidase activity(GO:0008239)
0.0	0.2	GO:0019198	transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0	0.1	GO:0043539	protein serine/threonine kinase activator activity(GO:0043539)
0.0	0.1	GO:0097506	uracil DNA N-glycosylase activity(GO:0004844) deaminated base DNA N-glycosylase activity(GO:0097506)
0.0	0.1	GO:0015165	pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.0	0.0	GO:0016362	activin receptor activity, type II(GO:0016362)
0.0	0.0	GO:0034481	chondroitin sulfotransferase activity(GO:0034481)
0.0	0.1	GO:0030515	snoRNA binding(GO:0030515)
0.0	0.1	GO:0055056	D-glucose transmembrane transporter activity(GO:0055056)
0.0	0.1	GO:0003923	GPI-anchor transamidase activity(GO:0003923)
0.0	0.0	GO:0017070	U6 snRNA binding(GO:0017070)
0.0	0.1	GO:0001640	adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640) G-protein coupled glutamate receptor activity(GO:0098988)
0.0	0.0	GO:0015321	sodium-dependent phosphate transmembrane transporter activity(GO:0015321)
0.0	0.1	GO:0017154	semaphorin receptor activity(GO:0017154)
0.0	0.1	GO:0003691	double-stranded telomeric DNA binding(GO:0003691)
0.0	0.1	GO:0051920	peroxiredoxin activity(GO:0051920)
0.0	0.1	GO:0005522	profilin binding(GO:0005522)
0.0	0.2	GO:0043130	ubiquitin binding(GO:0043130)
0.0	0.1	GO:0015288	porin activity(GO:0015288)
0.0	0.1	GO:0015166	polyol transmembrane transporter activity(GO:0015166)
0.0	0.1	GO:0005159	insulin-like growth factor receptor binding(GO:0005159)
0.0	0.1	GO:0050811	GABA receptor binding(GO:0050811)
0.0	0.2	GO:0008353	RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.0	0.0	GO:0004127	cytidylate kinase activity(GO:0004127)
0.0	0.1	GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0	0.1	GO:0017080	sodium channel regulator activity(GO:0017080)
0.0	0.2	GO:0000146	microfilament motor activity(GO:0000146)
0.0	0.1	GO:0008158	hedgehog receptor activity(GO:0008158)
0.0	0.1	GO:0051721	protein phosphatase 2A binding(GO:0051721)
0.0	0.3	GO:0002039	p53 binding(GO:0002039)
0.0	0.1	GO:0003709	obsolete RNA polymerase III transcription factor activity(GO:0003709)
0.0	0.0	GO:0022897	peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897)
0.0	0.0	GO:0004619	bisphosphoglycerate mutase activity(GO:0004082) bisphosphoglycerate 2-phosphatase activity(GO:0004083) phosphoglycerate mutase activity(GO:0004619)
0.0	0.0	GO:0004430	1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.0	0.0	GO:0000268	peroxisome targeting sequence binding(GO:0000268)
0.0	0.0	GO:0016149	translation release factor activity, codon specific(GO:0016149)
0.0	0.0	GO:0005375	copper ion transmembrane transporter activity(GO:0005375)
0.0	0.0	GO:0004966	galanin receptor activity(GO:0004966)
0.0	0.1	GO:0008467	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0	0.1	GO:0031996	thioesterase binding(GO:0031996)
0.0	0.0	GO:0004690	cyclic nucleotide-dependent protein kinase activity(GO:0004690)
0.0	0.0	GO:0005346	purine ribonucleotide transmembrane transporter activity(GO:0005346)
0.0	0.0	GO:0052650	NADP-retinol dehydrogenase activity(GO:0052650)
0.0	0.0	GO:0004999	vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.0	0.2	GO:0004177	aminopeptidase activity(GO:0004177)
0.0	0.3	GO:0003823	antigen binding(GO:0003823)
0.0	0.1	GO:0008242	omega peptidase activity(GO:0008242)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.9	PID REELIN PATHWAY	Reelin signaling pathway
0.0	0.4	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0	2.0	PID CD8 TCR PATHWAY	TCR signaling in naïve CD8+ T cells
0.0	0.1	PID IL2 1PATHWAY	IL2-mediated signaling events
0.0	0.2	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.0	1.4	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0	0.4	PID ARF6 DOWNSTREAM PATHWAY	Arf6 downstream pathway
0.0	0.3	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0	0.3	PID P38 ALPHA BETA PATHWAY	Regulation of p38-alpha and p38-beta
0.0	0.5	PID CD40 PATHWAY	CD40/CD40L signaling
0.0	0.7	PID CDC42 REG PATHWAY	Regulation of CDC42 activity
0.0	0.9	PID NFAT 3PATHWAY	Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.0	0.3	PID BETA CATENIN DEG PATHWAY	Degradation of beta catenin
0.0	0.1	ST IL 13 PATHWAY	Interleukin 13 (IL-13) Pathway
0.0	0.1	PID RETINOIC ACID PATHWAY	Retinoic acid receptors-mediated signaling
0.0	0.1	PID HIV NEF PATHWAY	HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.0	0.0	PID IL8 CXCR2 PATHWAY	IL8- and CXCR2-mediated signaling events
0.0	0.7	PID TGFBR PATHWAY	TGF-beta receptor signaling
0.0	0.4	SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES	Genes related to the insulin receptor pathway
0.0	0.2	PID VEGFR1 PATHWAY	VEGFR1 specific signals
0.0	0.0	SIG PIP3 SIGNALING IN B LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes
0.0	0.2	PID IL27 PATHWAY	IL27-mediated signaling events
0.0	0.1	SIG BCR SIGNALING PATHWAY	Members of the BCR signaling pathway
0.0	0.2	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.0	0.0	PID S1P S1P1 PATHWAY	S1P1 pathway
0.0	0.4	PID LKB1 PATHWAY	LKB1 signaling events
0.0	0.2	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0	0.5	PID AURORA B PATHWAY	Aurora B signaling
0.0	0.0	SIG IL4RECEPTOR IN B LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes
0.0	0.1	PID MYC PATHWAY	C-MYC pathway
0.0	0.0	PID TXA2PATHWAY	Thromboxane A2 receptor signaling
0.0	0.0	PID CXCR3 PATHWAY	CXCR3-mediated signaling events
0.0	0.1	SA PROGRAMMED CELL DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0	0.1	PID RAC1 REG PATHWAY	Regulation of RAC1 activity
0.0	0.1	SA TRKA RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.0	0.6	PID BETA CATENIN NUC PATHWAY	Regulation of nuclear beta catenin signaling and target gene transcription
0.0	0.3	PID ERBB1 INTERNALIZATION PATHWAY	Internalization of ErbB1

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.1	REACTOME PECAM1 INTERACTIONS	Genes involved in PECAM1 interactions
0.0	0.6	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0	0.5	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.0	0.0	REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE	Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.0	0.3	REACTOME CD28 DEPENDENT PI3K AKT SIGNALING	Genes involved in CD28 dependent PI3K/Akt signaling
0.0	0.1	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.0	0.6	REACTOME CTLA4 INHIBITORY SIGNALING	Genes involved in CTLA4 inhibitory signaling
0.0	0.3	REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN	Genes involved in Platelet Adhesion to exposed collagen
0.0	0.3	REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA	Genes involved in Circadian Repression of Expression by REV-ERBA
0.0	0.6	REACTOME DOWNSTREAM TCR SIGNALING	Genes involved in Downstream TCR signaling
0.0	0.4	REACTOME COSTIMULATION BY THE CD28 FAMILY	Genes involved in Costimulation by the CD28 family
0.0	0.4	REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS	Genes involved in p130Cas linkage to MAPK signaling for integrins
0.0	1.5	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
0.0	0.7	REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE	Genes involved in Synthesis of PIPs at the plasma membrane
0.0	0.0	REACTOME APC C CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS	Genes involved in APC/C:Cdc20 mediated degradation of mitotic proteins
0.0	0.1	REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS	Genes involved in Elevation of cytosolic Ca2+ levels
0.0	0.2	REACTOME ACTIVATION OF RAC	Genes involved in Activation of Rac
0.0	0.5	REACTOME EFFECTS OF PIP2 HYDROLYSIS	Genes involved in Effects of PIP2 hydrolysis
0.0	0.6	REACTOME DAG AND IP3 SIGNALING	Genes involved in DAG and IP3 signaling
0.0	0.1	REACTOME SIGNALING BY EGFR IN CANCER	Genes involved in Signaling by EGFR in Cancer
0.0	0.1	REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION	Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0	0.2	REACTOME VITAMIN B5 PANTOTHENATE METABOLISM	Genes involved in Vitamin B5 (pantothenate) metabolism
0.0	0.2	REACTOME HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS	Genes involved in Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
0.0	0.1	REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS	Genes involved in Membrane binding and targetting of GAG proteins
0.0	0.3	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.0	0.1	REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER	Genes involved in RNA Polymerase III Transcription Initiation From Type 2 Promoter
0.0	0.5	REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION	Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0	0.3	REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	Genes involved in Regulation of gene expression in beta cells
0.0	0.2	REACTOME PROLACTIN RECEPTOR SIGNALING	Genes involved in Prolactin receptor signaling
0.0	0.4	REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0	0.1	REACTOME P38MAPK EVENTS	Genes involved in p38MAPK events
0.0	0.2	REACTOME IL RECEPTOR SHC SIGNALING	Genes involved in Interleukin receptor SHC signaling
0.0	0.3	REACTOME NOD1 2 SIGNALING PATHWAY	Genes involved in NOD1/2 Signaling Pathway
0.0	0.2	REACTOME RNA POL III TRANSCRIPTION TERMINATION	Genes involved in RNA Polymerase III Transcription Termination
0.0	0.3	REACTOME FORMATION OF INCISION COMPLEX IN GG NER	Genes involved in Formation of incision complex in GG-NER
0.0	0.1	REACTOME IL 6 SIGNALING	Genes involved in Interleukin-6 signaling
0.0	0.2	REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS	Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0	0.1	REACTOME MTORC1 MEDIATED SIGNALLING	Genes involved in mTORC1-mediated signalling
0.0	0.3	REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0	0.3	REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS	Genes involved in Termination of O-glycan biosynthesis
0.0	0.1	REACTOME EGFR DOWNREGULATION	Genes involved in EGFR downregulation
0.0	0.2	REACTOME PROLONGED ERK ACTIVATION EVENTS	Genes involved in Prolonged ERK activation events
0.0	0.2	REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0	0.3	REACTOME REGULATORY RNA PATHWAYS	Genes involved in Regulatory RNA pathways
0.0	0.6	REACTOME VOLTAGE GATED POTASSIUM CHANNELS	Genes involved in Voltage gated Potassium channels
0.0	0.2	REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING	Genes involved in Formation of ATP by chemiosmotic coupling
0.0	0.3	REACTOME SIGNAL TRANSDUCTION BY L1	Genes involved in Signal transduction by L1
0.0	0.2	REACTOME ZINC TRANSPORTERS	Genes involved in Zinc transporters
0.0	0.1	REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION	Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0	0.2	REACTOME DEADENYLATION OF MRNA	Genes involved in Deadenylation of mRNA
0.0	0.1	REACTOME BASIGIN INTERACTIONS	Genes involved in Basigin interactions
0.0	0.1	REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	Genes involved in DCC mediated attractive signaling
0.0	0.3	REACTOME INTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Intrinsic Pathway for Apoptosis
0.0	0.1	REACTOME G ALPHA1213 SIGNALLING EVENTS	Genes involved in G alpha (12/13) signalling events
0.0	0.1	REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL	Genes involved in AKT phosphorylates targets in the cytosol
0.0	0.0	REACTOME INTEGRATION OF PROVIRUS	Genes involved in Integration of provirus
0.0	0.1	REACTOME G2 M DNA DAMAGE CHECKPOINT	Genes involved in G2/M DNA damage checkpoint
0.0	0.0	REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1	Genes involved in Autodegradation of the E3 ubiquitin ligase COP1

Results for NFATC2_NFATC3

Z-value: 1.16

Motif logo

Transcription factors associated with NFATC2_NFATC3

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Activity of the NFATC2_NFATC3 motif across conditions

Conditions sorted by the z-value of the NFATC2_NFATC3 motif activity

Top target CREs of the motif:

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of NFATC2_NFATC3

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: