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ENCODE: H3K4me1 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for NFKB1

Z-value: 1.23

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Transcription factors associated with NFKB1

Gene Symbol	Gene ID	Gene Info
NFKB1 Ensembl NCBI GeneCards UniProt	ENSG00000109320.7	NFKB1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
NFKB1	chr4_103441772_103441923	17315	0.192702	0.94	1.4e-04	Click!
NFKB1	chr4_103501773_103501924	2827	0.300010	0.93	2.6e-04	Click!
NFKB1	chr4_103508048_103508199	9102	0.224562	0.93	2.9e-04	Click!
NFKB1	chr4_103508537_103508688	9591	0.223443	0.91	6.5e-04	Click!
NFKB1	chr4_103439720_103439932	15294	0.196873	0.90	8.3e-04	Click!

Activity of the NFKB1 motif across conditions

Conditions sorted by the z-value of the NFKB1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr3_33090529_33090761	0.74	GLB1	galactosidase, beta 1	47639	0.11
chr14_76006081_76006729	0.67	BATF	basic leucine zipper transcription factor, ATF-like	17502	0.16
chr16_84640518_84640816	0.64	COTL1	coactosin-like 1 (Dictyostelium)	10998	0.16
chr5_156641312_156641556	0.63	CTB-4E7.1		9956	0.13
chr22_42689321_42689472	0.63	TCF20	transcription factor 20 (AR1)	50226	0.13
chr17_40250698_40250849	0.59	DHX58	DEXH (Asp-Glu-X-His) box polypeptide 58	13708	0.09
chr17_72276562_72276971	0.57	DNAI2	dynein, axonemal, intermediate chain 2	885	0.45
chr1_26647230_26647381	0.56	UBXN11	UBX domain protein 11	2451	0.17
chr3_18794151_18794302	0.55	ENSG00000228956	.	6990	0.34
chr11_60850304_60850538	0.55	CD5	CD5 molecule	19446	0.16
chr1_55264905_55265056	0.53	TTC22	tetratricopeptide repeat domain 22	1891	0.25
chr10_64571462_64571613	0.51	EGR2	early growth response 2	4578	0.21
chr14_21538883_21539166	0.50	NDRG2	NDRG family member 2	7	0.88
chr15_66181382_66181533	0.49	RAB11A	RAB11A, member RAS oncogene family	19106	0.19
chr11_286134_286286	0.49	RP11-326C3.2		1095	0.25
chr11_13317651_13317839	0.48	ARNTL	aryl hydrocarbon receptor nuclear translocator-like	13788	0.26
chr18_13377615_13378173	0.48	LDLRAD4	low density lipoprotein receptor class A domain containing 4	4659	0.18
chr4_2489410_2489561	0.48	RNF4	ring finger protein 4	2053	0.31
chr6_91107785_91108329	0.48	ENSG00000252676	.	48434	0.16
chr19_5965498_5965678	0.48	RANBP3	RAN binding protein 3	12502	0.1
chr20_47419324_47419475	0.47	PREX1	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1	25021	0.23
chr15_70535119_70535350	0.47	ENSG00000200216	.	49659	0.18
chr4_100738820_100739031	0.47	DAPP1	dual adaptor of phosphotyrosine and 3-phosphoinositides	922	0.66
chr3_193821410_193821561	0.47	RP11-135A1.2		27505	0.18
chr2_219757049_219757365	0.47	WNT10A	wingless-type MMTV integration site family, member 10A	10324	0.11
chr10_72742471_72742709	0.46	PCBD1	pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha	94049	0.08
chr9_96362201_96362412	0.45	PHF2	PHD finger protein 2	23397	0.18
chr14_99684918_99685081	0.44	AL109767.1		44286	0.15
chr8_145806767_145806918	0.44	CTD-2517M22.9		2582	0.15
chr16_30562550_30562810	0.44	ZNF764	zinc finger protein 764	6904	0.07
chr11_118334021_118334172	0.44	KMT2A	lysine (K)-specific methyltransferase 2A	18450	0.1
chr14_91876296_91876447	0.43	CCDC88C	coiled-coil domain containing 88C	7319	0.25
chr19_46283041_46283318	0.43	DMPK	dystrophia myotonica-protein kinase	620	0.48
chr6_157204193_157204560	0.43	ARID1B	AT rich interactive domain 1B (SWI1-like)	18131	0.27
chr20_56193359_56193625	0.43	ZBP1	Z-DNA binding protein 1	1958	0.39
chr7_36661111_36661262	0.43	ENSG00000221561	.	20663	0.17
chr9_131672255_131672406	0.43	PHYHD1	phytanoyl-CoA dioxygenase domain containing 1	10844	0.11
chr5_96141131_96141340	0.42	CTD-2260A17.3		135	0.94
chr17_71589495_71589717	0.42	RP11-277J6.2		47559	0.14
chr16_57612267_57612540	0.42	GPR56	G protein-coupled receptor 56	32161	0.11
chr19_49839198_49839350	0.42	CD37	CD37 molecule	553	0.56
chr9_134143505_134143979	0.41	FAM78A	family with sequence similarity 78, member A	2138	0.29
chr13_46756767_46757026	0.41	LCP1	lymphocyte cytosolic protein 1 (L-plastin)	437	0.8
chr3_59924803_59924954	0.41	NPCDR1	nasopharyngeal carcinoma, down-regulated 1	32705	0.26
chr11_1876364_1876520	0.41	LSP1	lymphocyte-specific protein 1	2242	0.16
chr12_58153854_58154005	0.41	MARCH9	membrane-associated ring finger (C3HC4) 9	2659	0.09
chr12_111022388_111022644	0.41	PPTC7	PTC7 protein phosphatase homolog (S. cerevisiae)	1391	0.36
chr14_24046924_24047247	0.41	JPH4	junctophilin 4	909	0.42
chr2_202137440_202137733	0.41	CASP8	caspase 8, apoptosis-related cysteine peptidase	225	0.94
chr11_9862251_9862402	0.40	SBF2	SET binding factor 2	1176	0.37
chr15_92027521_92027672	0.40	SV2B	synaptic vesicle glycoprotein 2B	258496	0.02
chr15_69083939_69084090	0.40	ENSG00000265195	.	10250	0.23
chr7_44496571_44496722	0.40	NUDCD3	NudC domain containing 3	33833	0.15
chr2_16081360_16081718	0.40	MYCNOS	MYCN opposite strand	165	0.89
chr5_156652968_156653188	0.40	CTB-4E7.1		1688	0.28
chr11_59378216_59378367	0.39	OSBP	oxysterol binding protein	5326	0.13
chr2_113735290_113735441	0.39	IL36G	interleukin 36, gamma	231	0.92
chr17_76343735_76343886	0.39	SOCS3	suppressor of cytokine signaling 3	12345	0.14
chr8_144051895_144052046	0.39	LY6E	lymphocyte antigen 6 complex, locus E	47429	0.1
chr6_37481071_37481281	0.39	CCDC167	coiled-coil domain containing 167	13478	0.2
chr14_69584826_69584977	0.39	ENSG00000206768	.	25769	0.18
chr11_114217659_114217947	0.39	RP11-64D24.2		9490	0.18
chr4_4387520_4387671	0.39	NSG1	Homo sapiens neuron specific gene family member 1 (NSG1), transcript variant 3, mRNA.	388	0.89
chr5_96215523_96215674	0.38	ERAP2	endoplasmic reticulum aminopeptidase 2	330	0.87
chr2_8468501_8468695	0.38	AC011747.7		347298	0.01
chr3_17064504_17064655	0.38	PLCL2	phospholipase C-like 2	12593	0.22
chr11_86004444_86004595	0.38	C11orf73	chromosome 11 open reading frame 73	8734	0.19
chr9_100860283_100860503	0.38	TRIM14	tripartite motif containing 14	5550	0.2
chr4_37894193_37894870	0.38	TBC1D1	TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1	1811	0.44
chr12_68177291_68177442	0.37	RP11-335O4.3		112667	0.07
chr19_42382114_42382373	0.37	CD79A	CD79a molecule, immunoglobulin-associated alpha	868	0.44
chr19_38908290_38908478	0.37	RASGRP4	RAS guanyl releasing protein 4	8418	0.09
chr17_65409882_65410033	0.37	ENSG00000201547	.	4960	0.16
chr11_73721865_73722409	0.37	UCP3	uncoupling protein 3 (mitochondrial, proton carrier)	1657	0.32
chr14_65139760_65139972	0.37	PLEKHG3	pleckstrin homology domain containing, family G (with RhoGef domain) member 3	30954	0.17
chr1_9182292_9182443	0.37	GPR157	G protein-coupled receptor 157	6816	0.17
chr1_27961026_27961296	0.37	FGR	feline Gardner-Rasheed sarcoma viral oncogene homolog	566	0.68
chr12_105063980_105064272	0.37	ENSG00000264295	.	78715	0.1
chr16_68115229_68115482	0.37	NFATC3	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3	3892	0.13
chr10_90590706_90591168	0.36	ANKRD22	ankyrin repeat domain 22	20638	0.15
chr12_4082516_4082813	0.36	RP11-664D1.1		68278	0.12
chr6_159457792_159457943	0.36	TAGAP	T-cell activation RhoGTPase activating protein	8183	0.19
chr12_68385106_68385257	0.36	IFNG-AS1	IFNG antisense RNA 1	1872	0.5
chr9_92035991_92036147	0.36	SEMA4D	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D	2321	0.37
chr14_91863332_91863575	0.36	CCDC88C	coiled-coil domain containing 88C	20237	0.21
chr19_2052263_2052418	0.36	MKNK2	MAP kinase interacting serine/threonine kinase 2	1097	0.34
chr2_198076609_198076760	0.36	ANKRD44	ankyrin repeat domain 44	13922	0.2
chr10_126424854_126425234	0.36	FAM53B	family with sequence similarity 53, member B	6495	0.18
chr3_14470267_14470741	0.36	SLC6A6	solute carrier family 6 (neurotransmitter transporter), member 6	3674	0.28
chr15_31555674_31556263	0.35	KLF13	Kruppel-like factor 13	63090	0.13
chr18_3003132_3003283	0.35	LPIN2	lipin 2	8738	0.17
chr10_73454547_73455031	0.35	C10orf105	chromosome 10 open reading frame 105	24789	0.19
chr10_112602586_112603108	0.35	PDCD4	programmed cell death 4 (neoplastic transformation inhibitor)	28718	0.13
chr10_9336383_9336663	0.35	ENSG00000212505	.	637729	0.0
chr16_67813577_67813770	0.35	RANBP10	RAN binding protein 10	26787	0.09
chr12_111115979_111116149	0.35	HVCN1	hydrogen voltage-gated channel 1	10450	0.16
chr3_121373642_121373829	0.35	ENSG00000243544	.	592	0.48
chr15_40601498_40601800	0.35	PLCB2	phospholipase C, beta 2	1526	0.21
chr16_3146077_3146254	0.35	ZSCAN10	zinc finger and SCAN domain containing 10	3064	0.09
chr17_46517090_46517319	0.35	SKAP1	src kinase associated phosphoprotein 1	9623	0.14
chr1_181286343_181286494	0.35	CACNA1E	calcium channel, voltage-dependent, R type, alpha 1E subunit	95820	0.09
chr9_98444198_98444349	0.35	DKFZP434H0512	Protein LOC100506667; Putative uncharacterized protein DKFZp434H0512	90332	0.08
chr6_37123484_37123718	0.34	PIM1	pim-1 oncogene	14378	0.18
chr18_47486716_47486867	0.34	RP11-813F20.4		10536	0.19
chr3_43236443_43236646	0.34	ENSG00000222331	.	15819	0.22
chr10_124136204_124136523	0.34	PLEKHA1	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1	2013	0.32
chr13_24848573_24849154	0.33	SPATA13	spermatogenesis associated 13	2036	0.28
chr17_46484714_46484933	0.33	SKAP1	src kinase associated phosphoprotein 1	22729	0.12
chr12_3858731_3858882	0.33	EFCAB4B	EF-hand calcium binding domain 4B	3457	0.29
chr20_2722524_2722808	0.33	EBF4	early B-cell factor 4	35779	0.09
chr13_99216536_99217042	0.33	STK24	serine/threonine kinase 24	12328	0.21
chr22_31730141_31730401	0.33	RP3-400N23.6		1064	0.37
chr9_108165581_108165732	0.33	FSD1L	fibronectin type III and SPRY domain containing 1-like	44421	0.16
chr9_73021961_73022182	0.33	KLF9	Kruppel-like factor 9	7469	0.28
chr9_33137738_33137889	0.33	B4GALT1	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1	9616	0.16
chr17_27943593_27943795	0.33	CORO6	coronin 6	1441	0.2
chr1_9774574_9774847	0.33	PIK3CD	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta	3417	0.22
chr20_5296649_5296800	0.32	PROKR2	prokineticin receptor 2	654	0.76
chr3_196379983_196380199	0.32	PIGX	phosphatidylinositol glycan anchor biosynthesis, class X	13445	0.12
chr17_17087488_17087777	0.32	RP11-45M22.3		1236	0.32
chr14_65404309_65404460	0.32	GPX2	glutathione peroxidase 2 (gastrointestinal)	5054	0.12
chr3_46735633_46736482	0.32	ALS2CL	ALS2 C-terminal like	866	0.49
chr11_60873950_60874231	0.32	CD5	CD5 molecule	4109	0.21
chr12_113513206_113513364	0.32	DTX1	deltex homolog 1 (Drosophila)	17790	0.15
chr19_8583523_8583746	0.32	ZNF414	zinc finger protein 414	4590	0.13
chr4_40229105_40229274	0.32	RHOH	ras homolog family member H	27225	0.19
chr16_50730890_50731308	0.32	NOD2	nucleotide-binding oligomerization domain containing 2	49	0.96
chr3_195919316_195919605	0.32	ENSG00000222335	.	9760	0.14
chr10_64493160_64493418	0.32	ADO	2-aminoethanethiol (cysteamine) dioxygenase	71227	0.09
chr7_36325933_36326467	0.32	EEPD1	endonuclease/exonuclease/phosphatase family domain containing 1	10553	0.18
chr2_136814589_136814740	0.32	AC093391.2		44629	0.15
chr15_67204936_67205097	0.32	SMAD3	SMAD family member 3	151085	0.04
chr2_235332578_235332755	0.31	ARL4C	ADP-ribosylation factor-like 4C	72578	0.13
chr21_46337804_46338132	0.31	ITGB2	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)	2802	0.14
chr4_6137198_6137349	0.31	JAKMIP1	janus kinase and microtubule interacting protein 1	59071	0.14
chr12_4262653_4262869	0.31	CCND2	cyclin D2	120177	0.05
chr14_99692121_99692272	0.31	AL109767.1		37089	0.16
chr13_49077988_49078168	0.31	RCBTB2	regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2	29135	0.22
chr2_109234348_109234509	0.31	LIMS1	LIM and senescent cell antigen-like domains 1	3294	0.3
chr5_141386076_141386227	0.31	GNPDA1	glucosamine-6-phosphate deaminase 1	6208	0.17
chr20_2734143_2734294	0.31	CPXM1	carboxypeptidase X (M14 family), member 1	47065	0.08
chr1_26038694_26038845	0.31	MAN1C1	mannosidase, alpha, class 1C, member 1	2676	0.26
chr9_116112694_116113190	0.31	BSPRY	B-box and SPRY domain containing	1121	0.39
chr12_121848379_121848530	0.31	RNF34	ring finger protein 34, E3 ubiquitin protein ligase	1176	0.51
chr17_35298519_35298670	0.30	RP11-445F12.2		2161	0.21
chr1_166459519_166459725	0.30	FAM78B	family with sequence similarity 78, member B	323416	0.01
chr11_64821448_64821599	0.30	ENSG00000266123	.	4012	0.08
chr3_42059799_42059950	0.30	ULK4	unc-51 like kinase 4	55952	0.13
chrX_19833042_19833193	0.30	SH3KBP1	SH3-domain kinase binding protein 1	15248	0.27
chr5_40406098_40406422	0.30	ENSG00000265615	.	85840	0.1
chr11_5719864_5720015	0.30	TRIM22	tripartite motif containing 22	7682	0.12
chr8_144287595_144287746	0.30	GPIHBP1	glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1	7398	0.15
chr3_186252123_186252274	0.30	CRYGS	crystallin, gamma S	10042	0.17
chr15_29330394_29330545	0.30	APBA2	amyloid beta (A4) precursor protein-binding, family A, member 2	6058	0.28
chr16_50733857_50734060	0.30	NOD2	nucleotide-binding oligomerization domain containing 2	2908	0.16
chr6_150322514_150322665	0.30	RAET1K	retinoic acid early transcript 1K pseudogene	3704	0.19
chr8_74375126_74375277	0.30	RP11-434I12.2		106505	0.07
chr10_126367388_126367539	0.29	FAM53B-AS1	FAM53B antisense RNA 1	24731	0.19
chr2_197066450_197066719	0.29	ENSG00000239161	.	13462	0.18
chr17_75321389_75321609	0.29	SEPT9	septin 9	2807	0.3
chrX_48792186_48792645	0.29	PIM2	pim-2 oncogene	16114	0.08
chr14_21777648_21777955	0.29	RPGRIP1	retinitis pigmentosa GTPase regulator interacting protein 1	7897	0.16
chr10_14625977_14626446	0.29	FAM107B	family with sequence similarity 107, member B	11873	0.24
chr20_44994972_44995158	0.29	SLC35C2	solute carrier family 35 (GDP-fucose transporter), member C2	2022	0.33
chr5_141478725_141478876	0.29	NDFIP1	Nedd4 family interacting protein 1	9270	0.24
chr22_23583322_23583546	0.29	BCR	breakpoint cluster region	12713	0.16
chr17_47296320_47296793	0.29	ABI3	ABI family, member 3	369	0.83
chr4_147379710_147379861	0.29	SLC10A7	solute carrier family 10, member 7	63084	0.13
chr10_7233238_7233389	0.29	SFMBT2	Scm-like with four mbt domains 2	217394	0.02
chr7_99221023_99221247	0.29	ZSCAN25	zinc finger and SCAN domain containing 25	3905	0.17
chr5_176857213_176857619	0.28	GRK6	G protein-coupled receptor kinase 6	3561	0.12
chr6_144740266_144740510	0.28	UTRN	utrophin	75151	0.11
chr22_20229537_20229756	0.28	RTN4R	reticulon 4 receptor	1561	0.29
chrX_19763111_19763463	0.28	SH3KBP1	SH3-domain kinase binding protein 1	1242	0.62
chr11_2720199_2720447	0.28	KCNQ1OT1	KCNQ1 opposite strand/antisense transcript 1 (non-protein coding)	901	0.68
chr9_97347238_97347389	0.28	FBP2	fructose-1,6-bisphosphatase 2	8762	0.24
chr6_10656054_10656229	0.28	ENSG00000201048	.	18860	0.13
chr19_40459440_40459607	0.28	PSMC4	proteasome (prosome, macropain) 26S subunit, ATPase, 4	17389	0.14
chr21_45715633_45715784	0.28	PFKL	phosphofructokinase, liver	4226	0.11
chr13_96109760_96109911	0.28	CLDN10	claudin 10	23977	0.22
chr18_46362885_46363036	0.28	RP11-484L8.1		1819	0.46
chr17_56064502_56064792	0.28	VEZF1	vascular endothelial zinc finger 1	866	0.54
chr16_88921173_88921341	0.28	TRAPPC2L	trafficking protein particle complex 2-like	1371	0.23
chr10_74016888_74017047	0.28	DDIT4	DNA-damage-inducible transcript 4	16711	0.14
chr22_29976535_29976734	0.28	NIPSNAP1	nipsnap homolog 1 (C. elegans)	429	0.79
chr13_101177691_101177842	0.28	GGACT	gamma-glutamylamine cyclotransferase	8141	0.18
chr2_191883690_191883911	0.28	AC067945.2		1120	0.35
chr3_58102043_58102194	0.28	FLNB	filamin B, beta	33475	0.17
chr5_156451707_156451858	0.28	HAVCR1	hepatitis A virus cellular receptor 1	33625	0.15
chr10_8444237_8444486	0.28	ENSG00000212505	.	254433	0.02
chr16_57170035_57170227	0.28	CPNE2	copine II	17020	0.13
chr12_122087386_122087583	0.28	MORN3	MORN repeat containing 3	20076	0.15
chr12_54390196_54390380	0.28	HOXC-AS2	HOXC cluster antisense RNA 2	281	0.66
chr19_10450885_10451036	0.28	ICAM3	intercellular adhesion molecule 3	461	0.63
chr10_88299612_88299763	0.28	RP11-77P6.2		17985	0.18
chr4_123749245_123749396	0.28	ENSG00000253069	.	1151	0.39
chr19_16476504_16477086	0.27	EPS15L1	epidermal growth factor receptor pathway substrate 15-like 1	4031	0.18
chr1_36859369_36859520	0.27	LSM10	LSM10, U7 small nuclear RNA associated	4049	0.14
chr12_111108052_111108203	0.27	HVCN1	hydrogen voltage-gated channel 1	18387	0.14
chr12_56554135_56554286	0.27	MYL6	myosin, light chain 6, alkali, smooth muscle and non-muscle	2030	0.11

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of NFKB1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0002385	innate immune response in mucosa(GO:0002227) mucosal immune response(GO:0002385)
0.1	0.3	GO:0034219	carbohydrate transmembrane transport(GO:0034219)
0.1	0.2	GO:0030223	neutrophil differentiation(GO:0030223)
0.1	0.2	GO:0050862	positive regulation of T cell receptor signaling pathway(GO:0050862)
0.1	0.2	GO:0032928	regulation of superoxide anion generation(GO:0032928)
0.1	0.2	GO:0010815	bradykinin catabolic process(GO:0010815)
0.1	0.4	GO:0002483	antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.1	0.1	GO:0002251	organ or tissue specific immune response(GO:0002251)
0.1	0.3	GO:0051797	regulation of hair follicle development(GO:0051797)
0.1	0.2	GO:0036037	CD8-positive, alpha-beta T cell activation(GO:0036037) CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0	0.1	GO:0045875	negative regulation of sister chromatid cohesion(GO:0045875)
0.0	0.2	GO:0014819	regulation of skeletal muscle contraction(GO:0014819)
0.0	0.1	GO:0040016	embryonic cleavage(GO:0040016)
0.0	0.1	GO:0045341	MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343)
0.0	0.3	GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress(GO:0008631) cell death in response to oxidative stress(GO:0036473)
0.0	0.2	GO:1901339	activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0	0.0	GO:0010535	regulation of activation of Janus kinase activity(GO:0010533) regulation of activation of JAK2 kinase activity(GO:0010534) positive regulation of activation of JAK2 kinase activity(GO:0010535) positive regulation of activation of Janus kinase activity(GO:0010536)
0.0	0.1	GO:0006435	threonyl-tRNA aminoacylation(GO:0006435)
0.0	0.1	GO:0048293	isotype switching to IgE isotypes(GO:0048289) regulation of isotype switching to IgE isotypes(GO:0048293)
0.0	0.1	GO:0070777	D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0	0.3	GO:0060484	lung-associated mesenchyme development(GO:0060484)
0.0	0.1	GO:0001757	somite specification(GO:0001757)
0.0	0.1	GO:0060836	lymphatic endothelial cell differentiation(GO:0060836)
0.0	0.1	GO:0090286	cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.0	0.2	GO:0006346	methylation-dependent chromatin silencing(GO:0006346)
0.0	0.1	GO:2000008	regulation of protein localization to cell surface(GO:2000008)
0.0	0.2	GO:0007256	activation of JNKK activity(GO:0007256)
0.0	0.1	GO:0090224	regulation of spindle organization(GO:0090224)
0.0	0.6	GO:0002639	positive regulation of immunoglobulin production(GO:0002639)
0.0	0.1	GO:0002323	natural killer cell activation involved in immune response(GO:0002323) natural killer cell degranulation(GO:0043320)
0.0	0.1	GO:0021610	cranial nerve structural organization(GO:0021604) facial nerve morphogenesis(GO:0021610) facial nerve structural organization(GO:0021612)
0.0	0.1	GO:0071542	dopaminergic neuron differentiation(GO:0071542)
0.0	0.1	GO:0071294	cellular response to zinc ion(GO:0071294)
0.0	0.1	GO:0032968	positive regulation of transcription elongation from RNA polymerase II promoter(GO:0032968)
0.0	0.2	GO:1901019	regulation of ryanodine-sensitive calcium-release channel activity(GO:0060314) regulation of calcium ion transmembrane transporter activity(GO:1901019) regulation of cation channel activity(GO:2001257)
0.0	0.1	GO:0009134	nucleoside diphosphate catabolic process(GO:0009134) ribonucleoside diphosphate catabolic process(GO:0009191)
0.0	0.1	GO:0002085	inhibition of neuroepithelial cell differentiation(GO:0002085)
0.0	0.1	GO:0060648	mammary gland bud morphogenesis(GO:0060648)
0.0	0.1	GO:0060129	thyroid-stimulating hormone-secreting cell differentiation(GO:0060129)
0.0	0.2	GO:0042104	positive regulation of activated T cell proliferation(GO:0042104)
0.0	0.1	GO:0010716	regulation of extracellular matrix disassembly(GO:0010715) negative regulation of extracellular matrix disassembly(GO:0010716) regulation of extracellular matrix organization(GO:1903053) negative regulation of extracellular matrix organization(GO:1903054)
0.0	0.2	GO:0045071	negative regulation of viral genome replication(GO:0045071)
0.0	0.1	GO:0006384	transcription initiation from RNA polymerase III promoter(GO:0006384)
0.0	0.0	GO:0051152	positive regulation of smooth muscle cell differentiation(GO:0051152)
0.0	0.1	GO:2000344	positive regulation of acrosome reaction(GO:2000344)
0.0	0.1	GO:0042415	norepinephrine metabolic process(GO:0042415)
0.0	0.1	GO:0070934	CRD-mediated mRNA stabilization(GO:0070934)
0.0	0.1	GO:0002689	negative regulation of leukocyte chemotaxis(GO:0002689)
0.0	0.1	GO:0060054	positive regulation of epithelial cell proliferation involved in wound healing(GO:0060054)
0.0	0.1	GO:0032808	lacrimal gland development(GO:0032808)
0.0	0.1	GO:0050847	progesterone receptor signaling pathway(GO:0050847)
0.0	0.1	GO:0070306	lens fiber cell differentiation(GO:0070306)
0.0	0.0	GO:0045112	integrin biosynthetic process(GO:0045112)
0.0	0.1	GO:0090009	primitive streak formation(GO:0090009)
0.0	0.3	GO:0031648	protein destabilization(GO:0031648)
0.0	0.4	GO:0046834	lipid phosphorylation(GO:0046834)
0.0	0.1	GO:0001885	endothelial cell development(GO:0001885)
0.0	0.1	GO:0006686	sphingomyelin biosynthetic process(GO:0006686)
0.0	0.0	GO:2000516	positive regulation of CD4-positive, alpha-beta T cell differentiation(GO:0043372) positive regulation of CD4-positive, alpha-beta T cell activation(GO:2000516)
0.0	0.0	GO:0021783	preganglionic parasympathetic fiber development(GO:0021783)
0.0	0.0	GO:0060789	hair follicle placode formation(GO:0060789)
0.0	0.5	GO:0002286	T cell activation involved in immune response(GO:0002286)
0.0	0.1	GO:0090080	positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway(GO:0090080)
0.0	0.0	GO:0032914	transforming growth factor beta1 production(GO:0032905) regulation of transforming growth factor beta1 production(GO:0032908) positive regulation of transforming growth factor beta1 production(GO:0032914)
0.0	0.0	GO:0010831	positive regulation of myotube differentiation(GO:0010831)
0.0	0.1	GO:0034227	tRNA wobble base modification(GO:0002097) tRNA wobble uridine modification(GO:0002098) tRNA thio-modification(GO:0034227)
0.0	0.1	GO:0010956	negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137)
0.0	0.1	GO:0048149	behavioral response to ethanol(GO:0048149)
0.0	0.1	GO:0009713	catechol-containing compound biosynthetic process(GO:0009713) catecholamine biosynthetic process(GO:0042423)
0.0	0.0	GO:0033152	immunoglobulin V(D)J recombination(GO:0033152)
0.0	0.1	GO:0071503	response to heparin(GO:0071503)
0.0	0.0	GO:0071635	negative regulation of transforming growth factor beta production(GO:0071635)
0.0	0.1	GO:0006420	arginyl-tRNA aminoacylation(GO:0006420)
0.0	0.1	GO:0034625	fatty acid elongation, monounsaturated fatty acid(GO:0034625)
0.0	0.1	GO:0060396	growth hormone receptor signaling pathway(GO:0060396) cellular response to growth hormone stimulus(GO:0071378)
0.0	0.2	GO:0046348	amino sugar catabolic process(GO:0046348) glucosamine-containing compound catabolic process(GO:1901072)
0.0	0.0	GO:0031943	regulation of glucocorticoid metabolic process(GO:0031943)
0.0	0.4	GO:0007212	dopamine receptor signaling pathway(GO:0007212)
0.0	0.1	GO:0043268	positive regulation of potassium ion transport(GO:0043268)
0.0	0.0	GO:0002669	lymphocyte anergy(GO:0002249) regulation of T cell anergy(GO:0002667) positive regulation of T cell anergy(GO:0002669) T cell anergy(GO:0002870) regulation of lymphocyte anergy(GO:0002911) positive regulation of lymphocyte anergy(GO:0002913)
0.0	0.1	GO:0017121	phospholipid scrambling(GO:0017121)
0.0	0.1	GO:0039656	modulation by virus of host gene expression(GO:0039656)
0.0	0.0	GO:0001705	ectoderm formation(GO:0001705)
0.0	0.1	GO:0046831	regulation of RNA export from nucleus(GO:0046831)
0.0	0.1	GO:0051709	regulation of killing of cells of other organism(GO:0051709)
0.0	0.1	GO:0006801	superoxide metabolic process(GO:0006801)
0.0	0.0	GO:0010882	regulation of cardiac muscle contraction by calcium ion signaling(GO:0010882)
0.0	0.1	GO:0042816	pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 metabolic process(GO:0042816) vitamin B6 biosynthetic process(GO:0042819)
0.0	0.0	GO:0042940	D-amino acid transport(GO:0042940)
0.0	0.1	GO:0051583	dopamine uptake involved in synaptic transmission(GO:0051583) catecholamine uptake involved in synaptic transmission(GO:0051934) catecholamine uptake(GO:0090493) dopamine uptake(GO:0090494)
0.0	0.1	GO:0021873	forebrain neuroblast division(GO:0021873)
0.0	0.0	GO:0032785	negative regulation of DNA-templated transcription, elongation(GO:0032785) negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244)
0.0	0.1	GO:0097576	vacuole fusion(GO:0097576)
0.0	0.1	GO:0000966	RNA 5'-end processing(GO:0000966)
0.0	0.1	GO:0051657	maintenance of organelle location(GO:0051657)
0.0	0.0	GO:0070102	interleukin-6-mediated signaling pathway(GO:0070102)
0.0	0.0	GO:0046512	diol biosynthetic process(GO:0034312) sphingosine biosynthetic process(GO:0046512)
0.0	0.1	GO:0034650	cortisol metabolic process(GO:0034650) cortisol biosynthetic process(GO:0034651)
0.0	0.1	GO:0007172	signal complex assembly(GO:0007172)
0.0	0.0	GO:0070296	sarcoplasmic reticulum calcium ion transport(GO:0070296)
0.0	0.1	GO:0006388	RNA splicing, via endonucleolytic cleavage and ligation(GO:0000394) tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.0	0.0	GO:0002093	auditory receptor cell morphogenesis(GO:0002093) auditory receptor cell stereocilium organization(GO:0060088)
0.0	0.0	GO:0071921	establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
0.0	0.1	GO:0071392	cellular response to estradiol stimulus(GO:0071392)
0.0	0.0	GO:0002862	negative regulation of inflammatory response to antigenic stimulus(GO:0002862)
0.0	0.1	GO:0006654	phosphatidic acid biosynthetic process(GO:0006654)
0.0	0.1	GO:0006857	oligopeptide transport(GO:0006857)
0.0	0.0	GO:0048752	semicircular canal morphogenesis(GO:0048752)
0.0	0.1	GO:0035235	ionotropic glutamate receptor signaling pathway(GO:0035235)
0.0	0.0	GO:0009448	gamma-aminobutyric acid metabolic process(GO:0009448)
0.0	0.2	GO:0060079	excitatory postsynaptic potential(GO:0060079)
0.0	0.1	GO:0008089	anterograde axonal transport(GO:0008089)
0.0	0.0	GO:0098754	detoxification of inorganic compound(GO:0061687) stress response to metal ion(GO:0097501) detoxification(GO:0098754)
0.0	0.0	GO:0016081	synaptic vesicle docking(GO:0016081)
0.0	0.1	GO:0000303	response to superoxide(GO:0000303)
0.0	0.1	GO:0007090	obsolete regulation of S phase of mitotic cell cycle(GO:0007090)
0.0	0.2	GO:0071445	obsolete cellular response to protein stimulus(GO:0071445)
0.0	0.0	GO:0002726	positive regulation of T cell cytokine production(GO:0002726)
0.0	0.0	GO:0045066	regulatory T cell differentiation(GO:0045066)
0.0	0.1	GO:0008608	attachment of spindle microtubules to kinetochore(GO:0008608)
0.0	0.2	GO:0045730	respiratory burst(GO:0045730)
0.0	0.0	GO:0032693	negative regulation of interleukin-10 production(GO:0032693) interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.0	0.1	GO:0030146	obsolete diuresis(GO:0030146)
0.0	0.1	GO:0008218	bioluminescence(GO:0008218)
0.0	0.0	GO:0033194	response to hydroperoxide(GO:0033194)
0.0	0.1	GO:0031935	regulation of chromatin silencing(GO:0031935)
0.0	0.1	GO:0060040	retinal bipolar neuron differentiation(GO:0060040)
0.0	0.1	GO:0019317	fucose catabolic process(GO:0019317) L-fucose metabolic process(GO:0042354) L-fucose catabolic process(GO:0042355)
0.0	0.2	GO:0006342	chromatin silencing(GO:0006342)
0.0	0.1	GO:0006349	regulation of gene expression by genetic imprinting(GO:0006349)
0.0	0.0	GO:0002827	positive regulation of T-helper 1 type immune response(GO:0002827)
0.0	0.1	GO:0007130	synaptonemal complex assembly(GO:0007130)
0.0	0.1	GO:0006337	nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.0	0.0	GO:0006772	thiamine metabolic process(GO:0006772)
0.0	0.1	GO:0015671	oxygen transport(GO:0015671)
0.0	0.2	GO:0045646	regulation of erythrocyte differentiation(GO:0045646)
0.0	0.0	GO:0032801	receptor catabolic process(GO:0032801)
0.0	0.0	GO:0051446	positive regulation of meiotic nuclear division(GO:0045836) positive regulation of meiotic cell cycle(GO:0051446)
0.0	0.1	GO:0006000	fructose metabolic process(GO:0006000)
0.0	0.1	GO:0015886	heme transport(GO:0015886)
0.0	0.0	GO:0018343	protein farnesylation(GO:0018343)
0.0	0.0	GO:0006007	glucose catabolic process(GO:0006007)
0.0	0.3	GO:0050771	negative regulation of axonogenesis(GO:0050771)
0.0	0.0	GO:0016576	histone dephosphorylation(GO:0016576)
0.0	0.0	GO:0002541	activation of plasma proteins involved in acute inflammatory response(GO:0002541)
0.0	0.0	GO:0010508	positive regulation of autophagy(GO:0010508)
0.0	0.0	GO:0034421	post-translational protein acetylation(GO:0034421)
0.0	0.1	GO:0006554	lysine metabolic process(GO:0006553) lysine catabolic process(GO:0006554)
0.0	0.1	GO:0002418	immune response to tumor cell(GO:0002418)
0.0	0.0	GO:0010447	response to acidic pH(GO:0010447)
0.0	0.0	GO:0046337	phosphatidylethanolamine biosynthetic process(GO:0006646) phosphatidylethanolamine metabolic process(GO:0046337)
0.0	0.0	GO:0048845	venous blood vessel morphogenesis(GO:0048845)
0.0	0.0	GO:0043137	DNA replication, Okazaki fragment processing(GO:0033567) DNA replication, removal of RNA primer(GO:0043137)
0.0	0.0	GO:0044240	multicellular organism lipid catabolic process(GO:0044240)
0.0	0.0	GO:0006689	ganglioside catabolic process(GO:0006689)
0.0	0.1	GO:0090231	regulation of spindle checkpoint(GO:0090231)
0.0	0.1	GO:0010759	regulation of macrophage chemotaxis(GO:0010758) positive regulation of macrophage chemotaxis(GO:0010759) mononuclear cell migration(GO:0071674) regulation of mononuclear cell migration(GO:0071675)
0.0	0.3	GO:0008633	obsolete activation of pro-apoptotic gene products(GO:0008633)
0.0	0.1	GO:0042744	hydrogen peroxide catabolic process(GO:0042744)
0.0	0.0	GO:0009822	alkaloid catabolic process(GO:0009822)
0.0	0.0	GO:0002903	negative regulation of B cell apoptotic process(GO:0002903)
0.0	0.0	GO:0031282	regulation of guanylate cyclase activity(GO:0031282)
0.0	0.1	GO:0048096	chromatin-mediated maintenance of transcription(GO:0048096)
0.0	0.0	GO:0000281	mitotic cytokinesis(GO:0000281)
0.0	0.0	GO:0072201	negative regulation of mesenchymal cell proliferation(GO:0072201)
0.0	0.4	GO:0030049	muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)
0.0	0.1	GO:0016556	mRNA modification(GO:0016556)
0.0	0.2	GO:0050830	defense response to Gram-positive bacterium(GO:0050830)
0.0	0.0	GO:0006659	phosphatidylserine biosynthetic process(GO:0006659)
0.0	0.0	GO:0048859	formation of anatomical boundary(GO:0048859)
0.0	0.0	GO:0010939	regulation of necrotic cell death(GO:0010939)
0.0	0.0	GO:0045603	positive regulation of endothelial cell differentiation(GO:0045603)
0.0	0.1	GO:0015871	choline transport(GO:0015871)
0.0	0.1	GO:0008653	lipopolysaccharide metabolic process(GO:0008653)
0.0	0.0	GO:0046083	adenine salvage(GO:0006168) purine nucleobase salvage(GO:0043096) adenine metabolic process(GO:0046083) adenine biosynthetic process(GO:0046084)
0.0	0.0	GO:0019805	quinolinate biosynthetic process(GO:0019805)
0.0	0.4	GO:0006968	cellular defense response(GO:0006968)
0.0	0.0	GO:0005981	regulation of glycogen catabolic process(GO:0005981)
0.0	0.0	GO:0001574	ganglioside biosynthetic process(GO:0001574)
0.0	0.1	GO:0048169	regulation of long-term neuronal synaptic plasticity(GO:0048169)
0.0	0.0	GO:0043983	histone H4-K12 acetylation(GO:0043983)
0.0	0.0	GO:0051532	NFAT protein import into nucleus(GO:0051531) regulation of NFAT protein import into nucleus(GO:0051532)
0.0	0.0	GO:0045188	circadian sleep/wake cycle, non-REM sleep(GO:0042748) regulation of circadian sleep/wake cycle, non-REM sleep(GO:0045188)
0.0	0.0	GO:0072583	synaptic vesicle recycling(GO:0036465) synaptic vesicle endocytosis(GO:0048488) clathrin-mediated endocytosis(GO:0072583)
0.0	0.0	GO:0070193	synaptonemal complex organization(GO:0070193)
0.0	0.1	GO:0046579	positive regulation of Ras protein signal transduction(GO:0046579)
0.0	0.1	GO:0006398	mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.5	GO:0031264	death-inducing signaling complex(GO:0031264)
0.1	0.3	GO:0014701	junctional sarcoplasmic reticulum membrane(GO:0014701)
0.1	0.4	GO:0001891	phagocytic cup(GO:0001891)
0.1	0.4	GO:0017146	NMDA selective glutamate receptor complex(GO:0017146)
0.0	0.2	GO:0071437	invadopodium(GO:0071437)
0.0	0.1	GO:0008537	proteasome activator complex(GO:0008537)
0.0	0.1	GO:0005896	interleukin-6 receptor complex(GO:0005896)
0.0	0.4	GO:0008180	COP9 signalosome(GO:0008180)
0.0	0.1	GO:0031235	intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0	0.1	GO:0001652	granular component(GO:0001652)
0.0	0.1	GO:0005862	muscle thin filament tropomyosin(GO:0005862)
0.0	0.1	GO:0034992	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0	0.1	GO:0031904	endosome lumen(GO:0031904)
0.0	0.2	GO:0071204	histone pre-mRNA 3'end processing complex(GO:0071204)
0.0	0.1	GO:0043218	compact myelin(GO:0043218)
0.0	0.3	GO:0005942	phosphatidylinositol 3-kinase complex(GO:0005942)
0.0	0.1	GO:0031362	anchored component of external side of plasma membrane(GO:0031362)
0.0	0.2	GO:0005861	troponin complex(GO:0005861)
0.0	0.1	GO:0045323	interleukin-1 receptor complex(GO:0045323)
0.0	0.0	GO:0033270	paranode region of axon(GO:0033270)
0.0	0.2	GO:0000242	pericentriolar material(GO:0000242)
0.0	0.1	GO:0005890	sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0	0.1	GO:0000791	euchromatin(GO:0000791)
0.0	0.1	GO:0030688	preribosome, small subunit precursor(GO:0030688)
0.0	0.1	GO:0072357	PTW/PP1 phosphatase complex(GO:0072357)
0.0	0.2	GO:0005858	axonemal dynein complex(GO:0005858)
0.0	0.3	GO:0090544	BAF-type complex(GO:0090544)
0.0	0.1	GO:0044224	juxtaparanode region of axon(GO:0044224)
0.0	0.0	GO:0030895	apolipoprotein B mRNA editing enzyme complex(GO:0030895)
0.0	0.1	GO:0030312	external encapsulating structure(GO:0030312)
0.0	0.0	GO:0032449	CBM complex(GO:0032449)
0.0	0.1	GO:0005826	actomyosin contractile ring(GO:0005826)
0.0	0.1	GO:0090576	RNA polymerase III transcription factor complex(GO:0090576)
0.0	0.2	GO:0045120	pronucleus(GO:0045120)
0.0	0.2	GO:0035631	CD40 receptor complex(GO:0035631)
0.0	0.0	GO:0005945	6-phosphofructokinase complex(GO:0005945)
0.0	0.0	GO:0071986	Ragulator complex(GO:0071986)
0.0	0.0	GO:0032059	bleb(GO:0032059)
0.0	0.0	GO:0031205	endoplasmic reticulum Sec complex(GO:0031205)
0.0	0.0	GO:0090533	cation-transporting ATPase complex(GO:0090533)
0.0	0.2	GO:0030914	STAGA complex(GO:0030914)
0.0	0.1	GO:0048786	presynaptic active zone(GO:0048786)
0.0	0.0	GO:0060199	clathrin-sculpted glutamate transport vesicle(GO:0060199) clathrin-sculpted glutamate transport vesicle membrane(GO:0060203)
0.0	0.1	GO:0034362	low-density lipoprotein particle(GO:0034362)
0.0	0.1	GO:0008290	F-actin capping protein complex(GO:0008290)
0.0	0.0	GO:0042583	chromaffin granule(GO:0042583) chromaffin granule membrane(GO:0042584)
0.0	0.0	GO:0030288	outer membrane-bounded periplasmic space(GO:0030288) periplasmic space(GO:0042597)
0.0	0.0	GO:0042105	alpha-beta T cell receptor complex(GO:0042105)
0.0	0.1	GO:0031254	uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0	0.1	GO:0090568	NuRD complex(GO:0016581) CHD-type complex(GO:0090545) nuclear transcriptional repressor complex(GO:0090568)
0.0	0.0	GO:0070022	transforming growth factor beta receptor homodimeric complex(GO:0070022)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0004591	oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.1	0.4	GO:0004972	NMDA glutamate receptor activity(GO:0004972)
0.1	0.2	GO:0003726	double-stranded RNA adenosine deaminase activity(GO:0003726)
0.1	0.4	GO:0042834	peptidoglycan binding(GO:0042834)
0.1	0.2	GO:0004911	interleukin-2 receptor activity(GO:0004911)
0.1	0.2	GO:0005105	type 1 fibroblast growth factor receptor binding(GO:0005105)
0.0	0.1	GO:0004999	vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.0	0.4	GO:0050780	dopamine receptor binding(GO:0050780)
0.0	0.1	GO:0042156	obsolete zinc-mediated transcriptional activator activity(GO:0042156)
0.0	0.2	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.0	0.3	GO:0015165	pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.0	0.2	GO:0015925	galactosidase activity(GO:0015925)
0.0	0.1	GO:0004829	threonine-tRNA ligase activity(GO:0004829)
0.0	0.1	GO:0016286	small conductance calcium-activated potassium channel activity(GO:0016286)
0.0	0.2	GO:0031014	troponin T binding(GO:0031014)
0.0	0.1	GO:0008321	Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0	0.1	GO:0004706	JUN kinase kinase kinase activity(GO:0004706)
0.0	0.2	GO:0003960	NADPH:quinone reductase activity(GO:0003960)
0.0	0.1	GO:0005078	MAP-kinase scaffold activity(GO:0005078)
0.0	0.2	GO:0016494	C-X-C chemokine receptor activity(GO:0016494)
0.0	0.2	GO:0008432	JUN kinase binding(GO:0008432)
0.0	0.2	GO:0008266	poly(U) RNA binding(GO:0008266)
0.0	0.1	GO:0016312	inositol bisphosphate phosphatase activity(GO:0016312)
0.0	0.2	GO:0005131	growth hormone receptor binding(GO:0005131)
0.0	0.2	GO:0005087	Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.0	0.2	GO:0050656	3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
0.0	0.2	GO:0016595	glutamate binding(GO:0016595)
0.0	0.2	GO:0004983	neuropeptide Y receptor activity(GO:0004983)
0.0	0.1	GO:0008109	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0	0.1	GO:0015252	hydrogen ion channel activity(GO:0015252)
0.0	0.1	GO:0050253	retinyl-palmitate esterase activity(GO:0050253)
0.0	0.3	GO:0005251	delayed rectifier potassium channel activity(GO:0005251)
0.0	0.1	GO:0017162	aryl hydrocarbon receptor binding(GO:0017162)
0.0	0.1	GO:0048406	nerve growth factor binding(GO:0048406)
0.0	0.1	GO:0043398	HLH domain binding(GO:0043398)
0.0	0.1	GO:0009374	biotin binding(GO:0009374)
0.0	0.0	GO:0047756	chondroitin 4-sulfotransferase activity(GO:0047756)
0.0	0.1	GO:0005138	interleukin-6 receptor binding(GO:0005138)
0.0	0.1	GO:0048027	mRNA 5'-UTR binding(GO:0048027)
0.0	0.2	GO:0070403	NAD+ binding(GO:0070403)
0.0	0.1	GO:0070290	N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0	0.1	GO:0052659	inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658) inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity(GO:0052659)
0.0	0.2	GO:0043325	phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0	0.1	GO:0031013	troponin I binding(GO:0031013)
0.0	0.1	GO:0071208	histone pre-mRNA DCP binding(GO:0071208)
0.0	0.1	GO:0030955	potassium ion binding(GO:0030955)
0.0	0.1	GO:0004814	arginine-tRNA ligase activity(GO:0004814)
0.0	0.2	GO:0008239	dipeptidyl-peptidase activity(GO:0008239)
0.0	0.1	GO:0004957	prostaglandin E receptor activity(GO:0004957)
0.0	0.1	GO:0017060	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity(GO:0017060)
0.0	0.1	GO:0017110	nucleoside-diphosphatase activity(GO:0017110)
0.0	0.1	GO:0017128	phospholipid scramblase activity(GO:0017128)
0.0	0.2	GO:0016493	C-C chemokine receptor activity(GO:0016493)
0.0	0.1	GO:0003886	DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0	0.4	GO:0005164	tumor necrosis factor receptor binding(GO:0005164)
0.0	0.1	GO:0004461	lactose synthase activity(GO:0004461)
0.0	0.1	GO:0016309	1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0	0.4	GO:0004177	aminopeptidase activity(GO:0004177)
0.0	0.1	GO:0010485	H4 histone acetyltransferase activity(GO:0010485)
0.0	0.1	GO:0005007	fibroblast growth factor-activated receptor activity(GO:0005007)
0.0	0.1	GO:0080025	phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0	0.1	GO:0005152	interleukin-1 receptor antagonist activity(GO:0005152)
0.0	0.3	GO:0043621	protein self-association(GO:0043621)
0.0	0.0	GO:0030151	molybdenum ion binding(GO:0030151)
0.0	0.1	GO:0004704	NF-kappaB-inducing kinase activity(GO:0004704)
0.0	0.3	GO:0051117	ATPase binding(GO:0051117)
0.0	0.1	GO:0004865	protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.0	0.1	GO:0046920	alpha-(1->3)-fucosyltransferase activity(GO:0046920)
0.0	0.1	GO:0001727	lipid kinase activity(GO:0001727)
0.0	0.1	GO:0003840	gamma-glutamyltransferase activity(GO:0003840)
0.0	0.1	GO:0015379	potassium:chloride symporter activity(GO:0015379)
0.0	0.1	GO:0022897	peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897)
0.0	0.1	GO:0050786	RAGE receptor binding(GO:0050786)
0.0	0.0	GO:0004566	beta-glucuronidase activity(GO:0004566)
0.0	0.1	GO:0030676	Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0	0.0	GO:0070061	fructose binding(GO:0070061)
0.0	0.0	GO:0004103	choline kinase activity(GO:0004103)
0.0	0.1	GO:0005521	lamin binding(GO:0005521)
0.0	0.0	GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.0	0.0	GO:0052743	inositol tetrakisphosphate phosphatase activity(GO:0052743)
0.0	0.1	GO:0005391	sodium:potassium-exchanging ATPase activity(GO:0005391)
0.0	0.1	GO:0015232	heme transporter activity(GO:0015232)
0.0	0.1	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0	0.1	GO:0008494	translation activator activity(GO:0008494)
0.0	0.1	GO:0019992	diacylglycerol binding(GO:0019992)
0.0	0.0	GO:0008559	xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.0	0.2	GO:0016411	acylglycerol O-acyltransferase activity(GO:0016411)
0.0	0.1	GO:0004308	exo-alpha-sialidase activity(GO:0004308) alpha-sialidase activity(GO:0016997)
0.0	0.3	GO:0004435	phosphatidylinositol phospholipase C activity(GO:0004435)
0.0	0.1	GO:0004568	chitinase activity(GO:0004568)
0.0	0.0	GO:0046980	tapasin binding(GO:0046980)
0.0	0.0	GO:0034237	protein kinase A regulatory subunit binding(GO:0034237)
0.0	0.1	GO:0004563	beta-N-acetylhexosaminidase activity(GO:0004563)
0.0	0.2	GO:0070888	E-box binding(GO:0070888)
0.0	0.0	GO:0004505	phenylalanine 4-monooxygenase activity(GO:0004505)
0.0	0.1	GO:0015929	hexosaminidase activity(GO:0015929)
0.0	0.1	GO:0031432	titin binding(GO:0031432)
0.0	0.1	GO:0005005	transmembrane-ephrin receptor activity(GO:0005005)
0.0	0.0	GO:0070996	type 1 melanocortin receptor binding(GO:0070996)
0.0	0.1	GO:0015220	choline transmembrane transporter activity(GO:0015220)
0.0	0.1	GO:0035251	UDP-glucosyltransferase activity(GO:0035251)
0.0	0.0	GO:0008526	phosphatidylinositol transporter activity(GO:0008526)
0.0	0.0	GO:0070548	L-glutamine aminotransferase activity(GO:0070548)
0.0	0.1	GO:0004985	opioid receptor activity(GO:0004985)
0.0	0.1	GO:0017108	5'-flap endonuclease activity(GO:0017108)
0.0	0.0	GO:0001758	retinal dehydrogenase activity(GO:0001758)
0.0	0.1	GO:0034593	phosphatidylinositol bisphosphate phosphatase activity(GO:0034593)
0.0	0.1	GO:0003688	DNA replication origin binding(GO:0003688)
0.0	0.1	GO:0051019	mitogen-activated protein kinase binding(GO:0051019)
0.0	0.1	GO:0003709	obsolete RNA polymerase III transcription factor activity(GO:0003709)
0.0	0.1	GO:0015279	store-operated calcium channel activity(GO:0015279)
0.0	0.0	GO:0004775	succinate-CoA ligase (ADP-forming) activity(GO:0004775)
0.0	0.0	GO:0015924	mannosyl-oligosaccharide mannosidase activity(GO:0015924)
0.0	0.0	GO:0030292	protein tyrosine kinase inhibitor activity(GO:0030292)
0.0	0.0	GO:0043125	ErbB-3 class receptor binding(GO:0043125)
0.0	0.0	GO:0004351	glutamate decarboxylase activity(GO:0004351)
0.0	0.0	GO:0004449	isocitrate dehydrogenase (NAD+) activity(GO:0004449)
0.0	0.0	GO:0005346	purine ribonucleotide transmembrane transporter activity(GO:0005346)
0.0	0.1	GO:0030306	ADP-ribosylation factor binding(GO:0030306)
0.0	0.0	GO:0016647	oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.5	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0	1.3	PID PI3KCI PATHWAY	Class I PI3K signaling events
0.0	0.2	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0	0.5	PID IL27 PATHWAY	IL27-mediated signaling events
0.0	0.4	PID NFKAPPAB CANONICAL PATHWAY	Canonical NF-kappaB pathway
0.0	0.0	PID PDGFRA PATHWAY	PDGFR-alpha signaling pathway
0.0	0.1	PID S1P S1P4 PATHWAY	S1P4 pathway
0.0	0.4	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.0	0.1	ST PAC1 RECEPTOR PATHWAY	PAC1 Receptor Pathway
0.0	0.1	PID WNT SIGNALING PATHWAY	Wnt signaling network
0.0	0.4	ST ERK1 ERK2 MAPK PATHWAY	ERK1/ERK2 MAPK Pathway
0.0	0.5	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
0.0	0.0	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
0.0	0.1	SA TRKA RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.0	0.0	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.0	0.3	PID REELIN PATHWAY	Reelin signaling pathway
0.0	0.1	PID RHOA PATHWAY	RhoA signaling pathway
0.0	0.2	PID ARF 3PATHWAY	Arf1 pathway
0.0	0.5	PID CD8 TCR DOWNSTREAM PATHWAY	Downstream signaling in naïve CD8+ T cells
0.0	0.1	ST PHOSPHOINOSITIDE 3 KINASE PATHWAY	PI3K Pathway
0.0	0.1	PID ARF6 DOWNSTREAM PATHWAY	Arf6 downstream pathway
0.0	0.2	ST DIFFERENTIATION PATHWAY IN PC12 CELLS	Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.0	0.1	PID CXCR4 PATHWAY	CXCR4-mediated signaling events
0.0	0.2	PID ALPHA SYNUCLEIN PATHWAY	Alpha-synuclein signaling
0.0	0.1	ST GRANULE CELL SURVIVAL PATHWAY	Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.0	0.0	PID IFNG PATHWAY	IFN-gamma pathway
0.0	0.1	ST STAT3 PATHWAY	STAT3 Pathway
0.0	0.1	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.2	REACTOME PECAM1 INTERACTIONS	Genes involved in PECAM1 interactions
0.4	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.4	REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1	Genes involved in Signaling by activated point mutants of FGFR1
0.5	REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII	Genes involved in CREB phosphorylation through the activation of CaMKII
0.7	REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.4	REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1	Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.2	REACTOME IL 6 SIGNALING	Genes involved in Interleukin-6 signaling
0.1	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.2	REACTOME REGULATED PROTEOLYSIS OF P75NTR	Genes involved in Regulated proteolysis of p75NTR
0.2	REACTOME PLATELET SENSITIZATION BY LDL	Genes involved in Platelet sensitization by LDL
0.7	REACTOME VOLTAGE GATED POTASSIUM CHANNELS	Genes involved in Voltage gated Potassium channels
0.0	REACTOME SIGNALING BY FGFR3 MUTANTS	Genes involved in Signaling by FGFR3 mutants
0.1	REACTOME ACTIVATION OF NF KAPPAB IN B CELLS	Genes involved in Activation of NF-kappaB in B Cells
0.2	REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS	Genes involved in CREB phosphorylation through the activation of Ras
0.0	REACTOME G PROTEIN ACTIVATION	Genes involved in G-protein activation
0.4	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.2	REACTOME GROWTH HORMONE RECEPTOR SIGNALING	Genes involved in Growth hormone receptor signaling
0.3	REACTOME GLUTATHIONE CONJUGATION	Genes involved in Glutathione conjugation
0.2	REACTOME IL RECEPTOR SHC SIGNALING	Genes involved in Interleukin receptor SHC signaling
0.0	REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION	Genes involved in activated TAK1 mediates p38 MAPK activation
0.1	REACTOME NEPHRIN INTERACTIONS	Genes involved in Nephrin interactions
0.1	REACTOME IL 2 SIGNALING	Genes involved in Interleukin-2 signaling
0.2	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.1	REACTOME PROLACTIN RECEPTOR SIGNALING	Genes involved in Prolactin receptor signaling
0.2	REACTOME CHONDROITIN SULFATE BIOSYNTHESIS	Genes involved in Chondroitin sulfate biosynthesis
0.1	REACTOME GABA A RECEPTOR ACTIVATION	Genes involved in GABA A receptor activation
0.2	REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI	Genes involved in RIP-mediated NFkB activation via DAI
0.1	REACTOME ACTIVATION OF RAC	Genes involved in Activation of Rac
0.7	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0	REACTOME OPSINS	Genes involved in Opsins
0.1	REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP	Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
0.0	REACTOME ANTIGEN PROCESSING CROSS PRESENTATION	Genes involved in Antigen processing-Cross presentation
0.1	REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.1	REACTOME NOTCH HLH TRANSCRIPTION PATHWAY	Genes involved in Notch-HLH transcription pathway
0.3	REACTOME TCR SIGNALING	Genes involved in TCR signaling