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ENCODE: H3K4me1 ChIP-Seq of primary human cells
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Results for NFKB1

Z-value: 1.23

Motif logo

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Transcription factors associated with NFKB1

Gene Symbol Gene ID Gene Info
NFKB1
ENSG00000109320.7 nuclear factor kappa B subunit 1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr4_103441772_103441923NFKB1173150.1927020.941.4e-04Click!
chr4_103501773_103501924NFKB128270.3000100.932.6e-04Click!
chr4_103508048_103508199NFKB191020.2245620.932.9e-04Click!
chr4_103508537_103508688NFKB195910.2234430.916.5e-04Click!
chr4_103439720_103439932NFKB1152940.1968730.908.3e-04Click!

Activity of the NFKB1 motif across conditions

Conditions sorted by the z-value of the NFKB1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr3_33090529_33090761 0.74 GLB1
 galactosidase, beta 1
 47639
 0.11
chr14_76006081_76006729 0.67 BATF
 basic leucine zipper transcription factor, ATF-like
 17502
 0.16
chr16_84640518_84640816 0.64 COTL1
 coactosin-like 1 (Dictyostelium)
 10998
 0.16
chr5_156641312_156641556 0.63 CTB-4E7.1
9956
 0.13
chr22_42689321_42689472 0.63 TCF20
 transcription factor 20 (AR1)
 50226
 0.13
chr17_40250698_40250849 0.59 DHX58
 DEXH (Asp-Glu-X-His) box polypeptide 58
 13708
 0.09
chr17_72276562_72276971 0.57 DNAI2
 dynein, axonemal, intermediate chain 2
 885
 0.45
chr1_26647230_26647381 0.56 UBXN11
 UBX domain protein 11
 2451
 0.17
chr3_18794151_18794302 0.55 ENSG00000228956
 .
 6990
 0.34
chr11_60850304_60850538 0.55 CD5
 CD5 molecule
 19446
 0.16
chr1_55264905_55265056 0.53 TTC22
 tetratricopeptide repeat domain 22
 1891
 0.25
chr10_64571462_64571613 0.51 EGR2
 early growth response 2
 4578
 0.21
chr14_21538883_21539166 0.50 NDRG2
 NDRG family member 2
 7
 0.88
chr15_66181382_66181533 0.49 RAB11A
 RAB11A, member RAS oncogene family
 19106
 0.19
chr11_286134_286286 0.49 RP11-326C3.2
1095
 0.25
chr11_13317651_13317839 0.48 ARNTL
 aryl hydrocarbon receptor nuclear translocator-like
 13788
 0.26
chr18_13377615_13378173 0.48 LDLRAD4
 low density lipoprotein receptor class A domain containing 4
 4659
 0.18
chr4_2489410_2489561 0.48 RNF4
 ring finger protein 4
 2053
 0.31
chr6_91107785_91108329 0.48 ENSG00000252676
 .
 48434
 0.16
chr19_5965498_5965678 0.48 RANBP3
 RAN binding protein 3
 12502
 0.1
chr20_47419324_47419475 0.47 PREX1
 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
 25021
 0.23
chr15_70535119_70535350 0.47 ENSG00000200216
 .
 49659
 0.18
chr4_100738820_100739031 0.47 DAPP1
 dual adaptor of phosphotyrosine and 3-phosphoinositides
 922
 0.66
chr3_193821410_193821561 0.47 RP11-135A1.2
27505
 0.18
chr2_219757049_219757365 0.47 WNT10A
 wingless-type MMTV integration site family, member 10A
 10324
 0.11
chr10_72742471_72742709 0.46 PCBD1
 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha
 94049
 0.08
chr9_96362201_96362412 0.45 PHF2
 PHD finger protein 2
 23397
 0.18
chr14_99684918_99685081 0.44 AL109767.1
44286
 0.15
chr8_145806767_145806918 0.44 CTD-2517M22.9
2582
 0.15
chr16_30562550_30562810 0.44 ZNF764
 zinc finger protein 764
 6904
 0.07
chr11_118334021_118334172 0.44 KMT2A
 lysine (K)-specific methyltransferase 2A
 18450
 0.1
chr14_91876296_91876447 0.43 CCDC88C
 coiled-coil domain containing 88C
 7319
 0.25
chr19_46283041_46283318 0.43 DMPK
 dystrophia myotonica-protein kinase
 620
 0.48
chr6_157204193_157204560 0.43 ARID1B
 AT rich interactive domain 1B (SWI1-like)
 18131
 0.27
chr20_56193359_56193625 0.43 ZBP1
 Z-DNA binding protein 1
 1958
 0.39
chr7_36661111_36661262 0.43 ENSG00000221561
 .
 20663
 0.17
chr9_131672255_131672406 0.43 PHYHD1
 phytanoyl-CoA dioxygenase domain containing 1
 10844
 0.11
chr5_96141131_96141340 0.42 CTD-2260A17.3
135
 0.94
chr17_71589495_71589717 0.42 RP11-277J6.2
47559
 0.14
chr16_57612267_57612540 0.42 GPR56
 G protein-coupled receptor 56
 32161
 0.11
chr19_49839198_49839350 0.42 CD37
 CD37 molecule
 553
 0.56
chr9_134143505_134143979 0.41 FAM78A
 family with sequence similarity 78, member A
 2138
 0.29
chr13_46756767_46757026 0.41 LCP1
 lymphocyte cytosolic protein 1 (L-plastin)
 437
 0.8
chr3_59924803_59924954 0.41 NPCDR1
 nasopharyngeal carcinoma, down-regulated 1
 32705
 0.26
chr11_1876364_1876520 0.41 LSP1
 lymphocyte-specific protein 1
 2242
 0.16
chr12_58153854_58154005 0.41 MARCH9
 membrane-associated ring finger (C3HC4) 9
 2659
 0.09
chr12_111022388_111022644 0.41 PPTC7
 PTC7 protein phosphatase homolog (S. cerevisiae)
 1391
 0.36
chr14_24046924_24047247 0.41 JPH4
 junctophilin 4
 909
 0.42
chr2_202137440_202137733 0.41 CASP8
 caspase 8, apoptosis-related cysteine peptidase
 225
 0.94
chr11_9862251_9862402 0.40 SBF2
 SET binding factor 2
 1176
 0.37
chr15_92027521_92027672 0.40 SV2B
 synaptic vesicle glycoprotein 2B
 258496
 0.02
chr15_69083939_69084090 0.40 ENSG00000265195
 .
 10250
 0.23
chr7_44496571_44496722 0.40 NUDCD3
 NudC domain containing 3
 33833
 0.15
chr2_16081360_16081718 0.40 MYCNOS
 MYCN opposite strand
 165
 0.89
chr5_156652968_156653188 0.40 CTB-4E7.1
1688
 0.28
chr11_59378216_59378367 0.39 OSBP
 oxysterol binding protein
 5326
 0.13
chr2_113735290_113735441 0.39 IL36G
 interleukin 36, gamma
 231
 0.92
chr17_76343735_76343886 0.39 SOCS3
 suppressor of cytokine signaling 3
 12345
 0.14
chr8_144051895_144052046 0.39 LY6E
 lymphocyte antigen 6 complex, locus E
 47429
 0.1
chr6_37481071_37481281 0.39 CCDC167
 coiled-coil domain containing 167
 13478
 0.2
chr14_69584826_69584977 0.39 ENSG00000206768
 .
 25769
 0.18
chr11_114217659_114217947 0.39 RP11-64D24.2
9490
 0.18
chr4_4387520_4387671 0.39 NSG1
 Homo sapiens neuron specific gene family member 1 (NSG1), transcript variant 3, mRNA.
 388
 0.89
chr5_96215523_96215674 0.38 ERAP2
 endoplasmic reticulum aminopeptidase 2
 330
 0.87
chr2_8468501_8468695 0.38 AC011747.7
347298
 0.01
chr3_17064504_17064655 0.38 PLCL2
 phospholipase C-like 2
 12593
 0.22
chr11_86004444_86004595 0.38 C11orf73
 chromosome 11 open reading frame 73
 8734
 0.19
chr9_100860283_100860503 0.38 TRIM14
 tripartite motif containing 14
 5550
 0.2
chr4_37894193_37894870 0.38 TBC1D1
 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
 1811
 0.44
chr12_68177291_68177442 0.37 RP11-335O4.3
112667
 0.07
chr19_42382114_42382373 0.37 CD79A
 CD79a molecule, immunoglobulin-associated alpha
 868
 0.44
chr19_38908290_38908478 0.37 RASGRP4
 RAS guanyl releasing protein 4
 8418
 0.09
chr17_65409882_65410033 0.37 ENSG00000201547
 .
 4960
 0.16
chr11_73721865_73722409 0.37 UCP3
 uncoupling protein 3 (mitochondrial, proton carrier)
 1657
 0.32
chr14_65139760_65139972 0.37 PLEKHG3
 pleckstrin homology domain containing, family G (with RhoGef domain) member 3
 30954
 0.17
chr1_9182292_9182443 0.37 GPR157
 G protein-coupled receptor 157
 6816
 0.17
chr1_27961026_27961296 0.37 FGR
 feline Gardner-Rasheed sarcoma viral oncogene homolog
 566
 0.68
chr12_105063980_105064272 0.37 ENSG00000264295
 .
 78715
 0.1
chr16_68115229_68115482 0.37 NFATC3
 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
 3892
 0.13
chr10_90590706_90591168 0.36 ANKRD22
 ankyrin repeat domain 22
 20638
 0.15
chr12_4082516_4082813 0.36 RP11-664D1.1
68278
 0.12
chr6_159457792_159457943 0.36 TAGAP
 T-cell activation RhoGTPase activating protein
 8183
 0.19
chr12_68385106_68385257 0.36 IFNG-AS1
 IFNG antisense RNA 1
 1872
 0.5
chr9_92035991_92036147 0.36 SEMA4D
 sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
 2321
 0.37
chr14_91863332_91863575 0.36 CCDC88C
 coiled-coil domain containing 88C
 20237
 0.21
chr19_2052263_2052418 0.36 MKNK2
 MAP kinase interacting serine/threonine kinase 2
 1097
 0.34
chr2_198076609_198076760 0.36 ANKRD44
 ankyrin repeat domain 44
 13922
 0.2
chr10_126424854_126425234 0.36 FAM53B
 family with sequence similarity 53, member B
 6495
 0.18
chr3_14470267_14470741 0.36 SLC6A6
 solute carrier family 6 (neurotransmitter transporter), member 6
 3674
 0.28
chr15_31555674_31556263 0.35 KLF13
 Kruppel-like factor 13
 63090
 0.13
chr18_3003132_3003283 0.35 LPIN2
 lipin 2
 8738
 0.17
chr10_73454547_73455031 0.35 C10orf105
 chromosome 10 open reading frame 105
 24789
 0.19
chr10_112602586_112603108 0.35 PDCD4
 programmed cell death 4 (neoplastic transformation inhibitor)
 28718
 0.13
chr10_9336383_9336663 0.35 ENSG00000212505
 .
 637729
 0.0
chr16_67813577_67813770 0.35 RANBP10
 RAN binding protein 10
 26787
 0.09
chr12_111115979_111116149 0.35 HVCN1
 hydrogen voltage-gated channel 1
 10450
 0.16
chr3_121373642_121373829 0.35 ENSG00000243544
 .
 592
 0.48
chr15_40601498_40601800 0.35 PLCB2
 phospholipase C, beta 2
 1526
 0.21
chr16_3146077_3146254 0.35 ZSCAN10
 zinc finger and SCAN domain containing 10
 3064
 0.09
chr17_46517090_46517319 0.35 SKAP1
 src kinase associated phosphoprotein 1
 9623
 0.14
chr1_181286343_181286494 0.35 CACNA1E
 calcium channel, voltage-dependent, R type, alpha 1E subunit
 95820
 0.09
chr9_98444198_98444349 0.35 DKFZP434H0512
 Protein LOC100506667; Putative uncharacterized protein DKFZp434H0512
 90332
 0.08
chr6_37123484_37123718 0.34 PIM1
 pim-1 oncogene
 14378
 0.18
chr18_47486716_47486867 0.34 RP11-813F20.4
10536
 0.19
chr3_43236443_43236646 0.34 ENSG00000222331
 .
 15819
 0.22
chr10_124136204_124136523 0.34 PLEKHA1
 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
 2013
 0.32
chr13_24848573_24849154 0.33 SPATA13
 spermatogenesis associated 13
 2036
 0.28
chr17_46484714_46484933 0.33 SKAP1
 src kinase associated phosphoprotein 1
 22729
 0.12
chr12_3858731_3858882 0.33 EFCAB4B
 EF-hand calcium binding domain 4B
 3457
 0.29
chr20_2722524_2722808 0.33 EBF4
 early B-cell factor 4
 35779
 0.09
chr13_99216536_99217042 0.33 STK24
 serine/threonine kinase 24
 12328
 0.21
chr22_31730141_31730401 0.33 RP3-400N23.6
1064
 0.37
chr9_108165581_108165732 0.33 FSD1L
 fibronectin type III and SPRY domain containing 1-like
 44421
 0.16
chr9_73021961_73022182 0.33 KLF9
 Kruppel-like factor 9
 7469
 0.28
chr9_33137738_33137889 0.33 B4GALT1
 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
 9616
 0.16
chr17_27943593_27943795 0.33 CORO6
 coronin 6
 1441
 0.2
chr1_9774574_9774847 0.33 PIK3CD
 phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
 3417
 0.22
chr20_5296649_5296800 0.32 PROKR2
 prokineticin receptor 2
 654
 0.76
chr3_196379983_196380199 0.32 PIGX
 phosphatidylinositol glycan anchor biosynthesis, class X
 13445
 0.12
chr17_17087488_17087777 0.32 RP11-45M22.3
1236
 0.32
chr14_65404309_65404460 0.32 GPX2
 glutathione peroxidase 2 (gastrointestinal)
 5054
 0.12
chr3_46735633_46736482 0.32 ALS2CL
 ALS2 C-terminal like
 866
 0.49
chr11_60873950_60874231 0.32 CD5
 CD5 molecule
 4109
 0.21
chr12_113513206_113513364 0.32 DTX1
 deltex homolog 1 (Drosophila)
 17790
 0.15
chr19_8583523_8583746 0.32 ZNF414
 zinc finger protein 414
 4590
 0.13
chr4_40229105_40229274 0.32 RHOH
 ras homolog family member H
 27225
 0.19
chr16_50730890_50731308 0.32 NOD2
 nucleotide-binding oligomerization domain containing 2
 49
 0.96
chr3_195919316_195919605 0.32 ENSG00000222335
 .
 9760
 0.14
chr10_64493160_64493418 0.32 ADO
 2-aminoethanethiol (cysteamine) dioxygenase
 71227
 0.09
chr7_36325933_36326467 0.32 EEPD1
 endonuclease/exonuclease/phosphatase family domain containing 1
 10553
 0.18
chr2_136814589_136814740 0.32 AC093391.2
44629
 0.15
chr15_67204936_67205097 0.32 SMAD3
 SMAD family member 3
 151085
 0.04
chr2_235332578_235332755 0.31 ARL4C
 ADP-ribosylation factor-like 4C
 72578
 0.13
chr21_46337804_46338132 0.31 ITGB2
 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
 2802
 0.14
chr4_6137198_6137349 0.31 JAKMIP1
 janus kinase and microtubule interacting protein 1
 59071
 0.14
chr12_4262653_4262869 0.31 CCND2
 cyclin D2
 120177
 0.05
chr14_99692121_99692272 0.31 AL109767.1
37089
 0.16
chr13_49077988_49078168 0.31 RCBTB2
 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
 29135
 0.22
chr2_109234348_109234509 0.31 LIMS1
 LIM and senescent cell antigen-like domains 1
 3294
 0.3
chr5_141386076_141386227 0.31 GNPDA1
 glucosamine-6-phosphate deaminase 1
 6208
 0.17
chr20_2734143_2734294 0.31 CPXM1
 carboxypeptidase X (M14 family), member 1
 47065
 0.08
chr1_26038694_26038845 0.31 MAN1C1
 mannosidase, alpha, class 1C, member 1
 2676
 0.26
chr9_116112694_116113190 0.31 BSPRY
 B-box and SPRY domain containing
 1121
 0.39
chr12_121848379_121848530 0.31 RNF34
 ring finger protein 34, E3 ubiquitin protein ligase
 1176
 0.51
chr17_35298519_35298670 0.30 RP11-445F12.2
2161
 0.21
chr1_166459519_166459725 0.30 FAM78B
 family with sequence similarity 78, member B
 323416
 0.01
chr11_64821448_64821599 0.30 ENSG00000266123
 .
 4012
 0.08
chr3_42059799_42059950 0.30 ULK4
 unc-51 like kinase 4
 55952
 0.13
chrX_19833042_19833193 0.30 SH3KBP1
 SH3-domain kinase binding protein 1
 15248
 0.27
chr5_40406098_40406422 0.30 ENSG00000265615
 .
 85840
 0.1
chr11_5719864_5720015 0.30 TRIM22
 tripartite motif containing 22
 7682
 0.12
chr8_144287595_144287746 0.30 GPIHBP1
 glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1
 7398
 0.15
chr3_186252123_186252274 0.30 CRYGS
 crystallin, gamma S
 10042
 0.17
chr15_29330394_29330545 0.30 APBA2
 amyloid beta (A4) precursor protein-binding, family A, member 2
 6058
 0.28
chr16_50733857_50734060 0.30 NOD2
 nucleotide-binding oligomerization domain containing 2
 2908
 0.16
chr6_150322514_150322665 0.30 RAET1K
 retinoic acid early transcript 1K pseudogene
 3704
 0.19
chr8_74375126_74375277 0.30 RP11-434I12.2
106505
 0.07
chr10_126367388_126367539 0.29 FAM53B-AS1
 FAM53B antisense RNA 1
 24731
 0.19
chr2_197066450_197066719 0.29 ENSG00000239161
 .
 13462
 0.18
chr17_75321389_75321609 0.29 SEPT9
 septin 9
 2807
 0.3
chrX_48792186_48792645 0.29 PIM2
 pim-2 oncogene
 16114
 0.08
chr14_21777648_21777955 0.29 RPGRIP1
 retinitis pigmentosa GTPase regulator interacting protein 1
 7897
 0.16
chr10_14625977_14626446 0.29 FAM107B
 family with sequence similarity 107, member B
 11873
 0.24
chr20_44994972_44995158 0.29 SLC35C2
 solute carrier family 35 (GDP-fucose transporter), member C2
 2022
 0.33
chr5_141478725_141478876 0.29 NDFIP1
 Nedd4 family interacting protein 1
 9270
 0.24
chr22_23583322_23583546 0.29 BCR
 breakpoint cluster region
 12713
 0.16
chr17_47296320_47296793 0.29 ABI3
 ABI family, member 3
 369
 0.83
chr4_147379710_147379861 0.29 SLC10A7
 solute carrier family 10, member 7
 63084
 0.13
chr10_7233238_7233389 0.29 SFMBT2
 Scm-like with four mbt domains 2
 217394
 0.02
chr7_99221023_99221247 0.29 ZSCAN25
 zinc finger and SCAN domain containing 25
 3905
 0.17
chr5_176857213_176857619 0.28 GRK6
 G protein-coupled receptor kinase 6
 3561
 0.12
chr6_144740266_144740510 0.28 UTRN
 utrophin
 75151
 0.11
chr22_20229537_20229756 0.28 RTN4R
 reticulon 4 receptor
 1561
 0.29
chrX_19763111_19763463 0.28 SH3KBP1
 SH3-domain kinase binding protein 1
 1242
 0.62
chr11_2720199_2720447 0.28 KCNQ1OT1
 KCNQ1 opposite strand/antisense transcript 1 (non-protein coding)
 901
 0.68
chr9_97347238_97347389 0.28 FBP2
 fructose-1,6-bisphosphatase 2
 8762
 0.24
chr6_10656054_10656229 0.28 ENSG00000201048
 .
 18860
 0.13
chr19_40459440_40459607 0.28 PSMC4
 proteasome (prosome, macropain) 26S subunit, ATPase, 4
 17389
 0.14
chr21_45715633_45715784 0.28 PFKL
 phosphofructokinase, liver
 4226
 0.11
chr13_96109760_96109911 0.28 CLDN10
 claudin 10
 23977
 0.22
chr18_46362885_46363036 0.28 RP11-484L8.1
1819
 0.46
chr17_56064502_56064792 0.28 VEZF1
 vascular endothelial zinc finger 1
 866
 0.54
chr16_88921173_88921341 0.28 TRAPPC2L
 trafficking protein particle complex 2-like
 1371
 0.23
chr10_74016888_74017047 0.28 DDIT4
 DNA-damage-inducible transcript 4
 16711
 0.14
chr22_29976535_29976734 0.28 NIPSNAP1
 nipsnap homolog 1 (C. elegans)
 429
 0.79
chr13_101177691_101177842 0.28 GGACT
 gamma-glutamylamine cyclotransferase
 8141
 0.18
chr2_191883690_191883911 0.28 AC067945.2
1120
 0.35
chr3_58102043_58102194 0.28 FLNB
 filamin B, beta
 33475
 0.17
chr5_156451707_156451858 0.28 HAVCR1
 hepatitis A virus cellular receptor 1
 33625
 0.15
chr10_8444237_8444486 0.28 ENSG00000212505
 .
 254433
 0.02
chr16_57170035_57170227 0.28 CPNE2
 copine II
 17020
 0.13
chr12_122087386_122087583 0.28 MORN3
 MORN repeat containing 3
 20076
 0.15
chr12_54390196_54390380 0.28 HOXC-AS2
 HOXC cluster antisense RNA 2
 281
 0.66
chr19_10450885_10451036 0.28 ICAM3
 intercellular adhesion molecule 3
 461
 0.63
chr10_88299612_88299763 0.28 RP11-77P6.2
17985
 0.18
chr4_123749245_123749396 0.28 ENSG00000253069
 .
 1151
 0.39
chr19_16476504_16477086 0.27 EPS15L1
 epidermal growth factor receptor pathway substrate 15-like 1
 4031
 0.18
chr1_36859369_36859520 0.27 LSM10
 LSM10, U7 small nuclear RNA associated
 4049
 0.14
chr12_111108052_111108203 0.27 HVCN1
 hydrogen voltage-gated channel 1
 18387
 0.14
chr12_56554135_56554286 0.27 MYL6
 myosin, light chain 6, alkali, smooth muscle and non-muscle
 2030
 0.11

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of NFKB1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0002385 innate immune response in mucosa(GO:0002227) mucosal immune response(GO:0002385)
0.1 0.3 GO:0034219 carbohydrate transmembrane transport(GO:0034219)
0.1 0.2 GO:0030223 neutrophil differentiation(GO:0030223)
0.1 0.2 GO:0050862 positive regulation of T cell receptor signaling pathway(GO:0050862)
0.1 0.2 GO:0032928 regulation of superoxide anion generation(GO:0032928)
0.1 0.2 GO:0010815 bradykinin catabolic process(GO:0010815)
0.1 0.4 GO:0002483 antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.1 0.1 GO:0002251 organ or tissue specific immune response(GO:0002251)
0.1 0.3 GO:0051797 regulation of hair follicle development(GO:0051797)
0.1 0.2 GO:0036037 CD8-positive, alpha-beta T cell activation(GO:0036037) CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0 0.1 GO:0045875 negative regulation of sister chromatid cohesion(GO:0045875)
0.0 0.2 GO:0014819 regulation of skeletal muscle contraction(GO:0014819)
0.0 0.1 GO:0040016 embryonic cleavage(GO:0040016)
0.0 0.1 GO:0045341 MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343)
0.0 0.3 GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress(GO:0008631) cell death in response to oxidative stress(GO:0036473)
0.0 0.2 GO:1901339 activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0 0.0 GO:0010535 regulation of activation of Janus kinase activity(GO:0010533) regulation of activation of JAK2 kinase activity(GO:0010534) positive regulation of activation of JAK2 kinase activity(GO:0010535) positive regulation of activation of Janus kinase activity(GO:0010536)
0.0 0.1 GO:0006435 threonyl-tRNA aminoacylation(GO:0006435)
0.0 0.1 GO:0048293 isotype switching to IgE isotypes(GO:0048289) regulation of isotype switching to IgE isotypes(GO:0048293)
0.0 0.1 GO:0070777 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0 0.3 GO:0060484 lung-associated mesenchyme development(GO:0060484)
0.0 0.1 GO:0001757 somite specification(GO:0001757)
0.0 0.1 GO:0060836 lymphatic endothelial cell differentiation(GO:0060836)
0.0 0.1 GO:0090286 cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.0 0.2 GO:0006346 methylation-dependent chromatin silencing(GO:0006346)
0.0 0.1 GO:2000008 regulation of protein localization to cell surface(GO:2000008)
0.0 0.2 GO:0007256 activation of JNKK activity(GO:0007256)
0.0 0.1 GO:0090224 regulation of spindle organization(GO:0090224)
0.0 0.6 GO:0002639 positive regulation of immunoglobulin production(GO:0002639)
0.0 0.1 GO:0002323 natural killer cell activation involved in immune response(GO:0002323) natural killer cell degranulation(GO:0043320)
0.0 0.1 GO:0021610 cranial nerve structural organization(GO:0021604) facial nerve morphogenesis(GO:0021610) facial nerve structural organization(GO:0021612)
0.0 0.1 GO:0071542 dopaminergic neuron differentiation(GO:0071542)
0.0 0.1 GO:0071294 cellular response to zinc ion(GO:0071294)
0.0 0.1 GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter(GO:0032968)
0.0 0.2 GO:1901019 regulation of ryanodine-sensitive calcium-release channel activity(GO:0060314) regulation of calcium ion transmembrane transporter activity(GO:1901019) regulation of cation channel activity(GO:2001257)
0.0 0.1 GO:0009134 nucleoside diphosphate catabolic process(GO:0009134) ribonucleoside diphosphate catabolic process(GO:0009191)
0.0 0.1 GO:0002085 inhibition of neuroepithelial cell differentiation(GO:0002085)
0.0 0.1 GO:0060648 mammary gland bud morphogenesis(GO:0060648)
0.0 0.1 GO:0060129 thyroid-stimulating hormone-secreting cell differentiation(GO:0060129)
0.0 0.2 GO:0042104 positive regulation of activated T cell proliferation(GO:0042104)
0.0 0.1 GO:0010716 regulation of extracellular matrix disassembly(GO:0010715) negative regulation of extracellular matrix disassembly(GO:0010716) regulation of extracellular matrix organization(GO:1903053) negative regulation of extracellular matrix organization(GO:1903054)
0.0 0.2 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.0 0.1 GO:0006384 transcription initiation from RNA polymerase III promoter(GO:0006384)
0.0 0.0 GO:0051152 positive regulation of smooth muscle cell differentiation(GO:0051152)
0.0 0.1 GO:2000344 positive regulation of acrosome reaction(GO:2000344)
0.0 0.1 GO:0042415 norepinephrine metabolic process(GO:0042415)
0.0 0.1 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
0.0 0.1 GO:0002689 negative regulation of leukocyte chemotaxis(GO:0002689)
0.0 0.1 GO:0060054 positive regulation of epithelial cell proliferation involved in wound healing(GO:0060054)
0.0 0.1 GO:0032808 lacrimal gland development(GO:0032808)
0.0 0.1 GO:0050847 progesterone receptor signaling pathway(GO:0050847)
0.0 0.1 GO:0070306 lens fiber cell differentiation(GO:0070306)
0.0 0.0 GO:0045112 integrin biosynthetic process(GO:0045112)
0.0 0.1 GO:0090009 primitive streak formation(GO:0090009)
0.0 0.3 GO:0031648 protein destabilization(GO:0031648)
0.0 0.4 GO:0046834 lipid phosphorylation(GO:0046834)
0.0 0.1 GO:0001885 endothelial cell development(GO:0001885)
0.0 0.1 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.0 0.0 GO:2000516 positive regulation of CD4-positive, alpha-beta T cell differentiation(GO:0043372) positive regulation of CD4-positive, alpha-beta T cell activation(GO:2000516)
0.0 0.0 GO:0021783 preganglionic parasympathetic fiber development(GO:0021783)
0.0 0.0 GO:0060789 hair follicle placode formation(GO:0060789)
0.0 0.5 GO:0002286 T cell activation involved in immune response(GO:0002286)
0.0 0.1 GO:0090080 positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway(GO:0090080)
0.0 0.0 GO:0032914 transforming growth factor beta1 production(GO:0032905) regulation of transforming growth factor beta1 production(GO:0032908) positive regulation of transforming growth factor beta1 production(GO:0032914)
0.0 0.0 GO:0010831 positive regulation of myotube differentiation(GO:0010831)
0.0 0.1 GO:0034227 tRNA wobble base modification(GO:0002097) tRNA wobble uridine modification(GO:0002098) tRNA thio-modification(GO:0034227)
0.0 0.1 GO:0010956 negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137)
0.0 0.1 GO:0048149 behavioral response to ethanol(GO:0048149)
0.0 0.1 GO:0009713 catechol-containing compound biosynthetic process(GO:0009713) catecholamine biosynthetic process(GO:0042423)
0.0 0.0 GO:0033152 immunoglobulin V(D)J recombination(GO:0033152)
0.0 0.1 GO:0071503 response to heparin(GO:0071503)
0.0 0.0 GO:0071635 negative regulation of transforming growth factor beta production(GO:0071635)
0.0 0.1 GO:0006420 arginyl-tRNA aminoacylation(GO:0006420)
0.0 0.1 GO:0034625 fatty acid elongation, monounsaturated fatty acid(GO:0034625)
0.0 0.1 GO:0060396 growth hormone receptor signaling pathway(GO:0060396) cellular response to growth hormone stimulus(GO:0071378)
0.0 0.2 GO:0046348 amino sugar catabolic process(GO:0046348) glucosamine-containing compound catabolic process(GO:1901072)
0.0 0.0 GO:0031943 regulation of glucocorticoid metabolic process(GO:0031943)
0.0 0.4 GO:0007212 dopamine receptor signaling pathway(GO:0007212)
0.0 0.1 GO:0043268 positive regulation of potassium ion transport(GO:0043268)
0.0 0.0 GO:0002669 lymphocyte anergy(GO:0002249) regulation of T cell anergy(GO:0002667) positive regulation of T cell anergy(GO:0002669) T cell anergy(GO:0002870) regulation of lymphocyte anergy(GO:0002911) positive regulation of lymphocyte anergy(GO:0002913)
0.0 0.1 GO:0017121 phospholipid scrambling(GO:0017121)
0.0 0.1 GO:0039656 modulation by virus of host gene expression(GO:0039656)
0.0 0.0 GO:0001705 ectoderm formation(GO:0001705)
0.0 0.1 GO:0046831 regulation of RNA export from nucleus(GO:0046831)
0.0 0.1 GO:0051709 regulation of killing of cells of other organism(GO:0051709)
0.0 0.1 GO:0006801 superoxide metabolic process(GO:0006801)
0.0 0.0 GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling(GO:0010882)
0.0 0.1 GO:0042816 pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 metabolic process(GO:0042816) vitamin B6 biosynthetic process(GO:0042819)
0.0 0.0 GO:0042940 D-amino acid transport(GO:0042940)
0.0 0.1 GO:0051583 dopamine uptake involved in synaptic transmission(GO:0051583) catecholamine uptake involved in synaptic transmission(GO:0051934) catecholamine uptake(GO:0090493) dopamine uptake(GO:0090494)
0.0 0.1 GO:0021873 forebrain neuroblast division(GO:0021873)
0.0 0.0 GO:0032785 negative regulation of DNA-templated transcription, elongation(GO:0032785) negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244)
0.0 0.1 GO:0097576 vacuole fusion(GO:0097576)
0.0 0.1 GO:0000966 RNA 5'-end processing(GO:0000966)
0.0 0.1 GO:0051657 maintenance of organelle location(GO:0051657)
0.0 0.0 GO:0070102 interleukin-6-mediated signaling pathway(GO:0070102)
0.0 0.0 GO:0046512 diol biosynthetic process(GO:0034312) sphingosine biosynthetic process(GO:0046512)
0.0 0.1 GO:0034650 cortisol metabolic process(GO:0034650) cortisol biosynthetic process(GO:0034651)
0.0 0.1 GO:0007172 signal complex assembly(GO:0007172)
0.0 0.0 GO:0070296 sarcoplasmic reticulum calcium ion transport(GO:0070296)
0.0 0.1 GO:0006388 RNA splicing, via endonucleolytic cleavage and ligation(GO:0000394) tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.0 0.0 GO:0002093 auditory receptor cell morphogenesis(GO:0002093) auditory receptor cell stereocilium organization(GO:0060088)
0.0 0.0 GO:0071921 establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
0.0 0.1 GO:0071392 cellular response to estradiol stimulus(GO:0071392)
0.0 0.0 GO:0002862 negative regulation of inflammatory response to antigenic stimulus(GO:0002862)
0.0 0.1 GO:0006654 phosphatidic acid biosynthetic process(GO:0006654)
0.0 0.1 GO:0006857 oligopeptide transport(GO:0006857)
0.0 0.0 GO:0048752 semicircular canal morphogenesis(GO:0048752)
0.0 0.1 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.0 0.0 GO:0009448 gamma-aminobutyric acid metabolic process(GO:0009448)
0.0 0.2 GO:0060079 excitatory postsynaptic potential(GO:0060079)
0.0 0.1 GO:0008089 anterograde axonal transport(GO:0008089)
0.0 0.0 GO:0098754 detoxification of inorganic compound(GO:0061687) stress response to metal ion(GO:0097501) detoxification(GO:0098754)
0.0 0.0 GO:0016081 synaptic vesicle docking(GO:0016081)
0.0 0.1 GO:0000303 response to superoxide(GO:0000303)
0.0 0.1 GO:0007090 obsolete regulation of S phase of mitotic cell cycle(GO:0007090)
0.0 0.2 GO:0071445 obsolete cellular response to protein stimulus(GO:0071445)
0.0 0.0 GO:0002726 positive regulation of T cell cytokine production(GO:0002726)
0.0 0.0 GO:0045066 regulatory T cell differentiation(GO:0045066)
0.0 0.1 GO:0008608 attachment of spindle microtubules to kinetochore(GO:0008608)
0.0 0.2 GO:0045730 respiratory burst(GO:0045730)
0.0 0.0 GO:0032693 negative regulation of interleukin-10 production(GO:0032693) interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.0 0.1 GO:0030146 obsolete diuresis(GO:0030146)
0.0 0.1 GO:0008218 bioluminescence(GO:0008218)
0.0 0.0 GO:0033194 response to hydroperoxide(GO:0033194)
0.0 0.1 GO:0031935 regulation of chromatin silencing(GO:0031935)
0.0 0.1 GO:0060040 retinal bipolar neuron differentiation(GO:0060040)
0.0 0.1 GO:0019317 fucose catabolic process(GO:0019317) L-fucose metabolic process(GO:0042354) L-fucose catabolic process(GO:0042355)
0.0 0.2 GO:0006342 chromatin silencing(GO:0006342)
0.0 0.1 GO:0006349 regulation of gene expression by genetic imprinting(GO:0006349)
0.0 0.0 GO:0002827 positive regulation of T-helper 1 type immune response(GO:0002827)
0.0 0.1 GO:0007130 synaptonemal complex assembly(GO:0007130)
0.0 0.1 GO:0006337 nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.0 0.0 GO:0006772 thiamine metabolic process(GO:0006772)
0.0 0.1 GO:0015671 oxygen transport(GO:0015671)
0.0 0.2 GO:0045646 regulation of erythrocyte differentiation(GO:0045646)
0.0 0.0 GO:0032801 receptor catabolic process(GO:0032801)
0.0 0.0 GO:0051446 positive regulation of meiotic nuclear division(GO:0045836) positive regulation of meiotic cell cycle(GO:0051446)
0.0 0.1 GO:0006000 fructose metabolic process(GO:0006000)
0.0 0.1 GO:0015886 heme transport(GO:0015886)
0.0 0.0 GO:0018343 protein farnesylation(GO:0018343)
0.0 0.0 GO:0006007 glucose catabolic process(GO:0006007)
0.0 0.3 GO:0050771 negative regulation of axonogenesis(GO:0050771)
0.0 0.0 GO:0016576 histone dephosphorylation(GO:0016576)
0.0 0.0 GO:0002541 activation of plasma proteins involved in acute inflammatory response(GO:0002541)
0.0 0.0 GO:0010508 positive regulation of autophagy(GO:0010508)
0.0 0.0 GO:0034421 post-translational protein acetylation(GO:0034421)
0.0 0.1 GO:0006554 lysine metabolic process(GO:0006553) lysine catabolic process(GO:0006554)
0.0 0.1 GO:0002418 immune response to tumor cell(GO:0002418)
0.0 0.0 GO:0010447 response to acidic pH(GO:0010447)
0.0 0.0 GO:0046337 phosphatidylethanolamine biosynthetic process(GO:0006646) phosphatidylethanolamine metabolic process(GO:0046337)
0.0 0.0 GO:0048845 venous blood vessel morphogenesis(GO:0048845)
0.0 0.0 GO:0043137 DNA replication, Okazaki fragment processing(GO:0033567) DNA replication, removal of RNA primer(GO:0043137)
0.0 0.0 GO:0044240 multicellular organism lipid catabolic process(GO:0044240)
0.0 0.0 GO:0006689 ganglioside catabolic process(GO:0006689)
0.0 0.1 GO:0090231 regulation of spindle checkpoint(GO:0090231)
0.0 0.1 GO:0010759 regulation of macrophage chemotaxis(GO:0010758) positive regulation of macrophage chemotaxis(GO:0010759) mononuclear cell migration(GO:0071674) regulation of mononuclear cell migration(GO:0071675)
0.0 0.3 GO:0008633 obsolete activation of pro-apoptotic gene products(GO:0008633)
0.0 0.1 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
0.0 0.0 GO:0009822 alkaloid catabolic process(GO:0009822)
0.0 0.0 GO:0002903 negative regulation of B cell apoptotic process(GO:0002903)
0.0 0.0 GO:0031282 regulation of guanylate cyclase activity(GO:0031282)
0.0 0.1 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.0 0.0 GO:0000281 mitotic cytokinesis(GO:0000281)
0.0 0.0 GO:0072201 negative regulation of mesenchymal cell proliferation(GO:0072201)
0.0 0.4 GO:0030049 muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)
0.0 0.1 GO:0016556 mRNA modification(GO:0016556)
0.0 0.2 GO:0050830 defense response to Gram-positive bacterium(GO:0050830)
0.0 0.0 GO:0006659 phosphatidylserine biosynthetic process(GO:0006659)
0.0 0.0 GO:0048859 formation of anatomical boundary(GO:0048859)
0.0 0.0 GO:0010939 regulation of necrotic cell death(GO:0010939)
0.0 0.0 GO:0045603 positive regulation of endothelial cell differentiation(GO:0045603)
0.0 0.1 GO:0015871 choline transport(GO:0015871)
0.0 0.1 GO:0008653 lipopolysaccharide metabolic process(GO:0008653)
0.0 0.0 GO:0046083 adenine salvage(GO:0006168) purine nucleobase salvage(GO:0043096) adenine metabolic process(GO:0046083) adenine biosynthetic process(GO:0046084)
0.0 0.0 GO:0019805 quinolinate biosynthetic process(GO:0019805)
0.0 0.4 GO:0006968 cellular defense response(GO:0006968)
0.0 0.0 GO:0005981 regulation of glycogen catabolic process(GO:0005981)
0.0 0.0 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.0 0.1 GO:0048169 regulation of long-term neuronal synaptic plasticity(GO:0048169)
0.0 0.0 GO:0043983 histone H4-K12 acetylation(GO:0043983)
0.0 0.0 GO:0051532 NFAT protein import into nucleus(GO:0051531) regulation of NFAT protein import into nucleus(GO:0051532)
0.0 0.0 GO:0045188 circadian sleep/wake cycle, non-REM sleep(GO:0042748) regulation of circadian sleep/wake cycle, non-REM sleep(GO:0045188)
0.0 0.0 GO:0072583 synaptic vesicle recycling(GO:0036465) synaptic vesicle endocytosis(GO:0048488) clathrin-mediated endocytosis(GO:0072583)
0.0 0.0 GO:0070193 synaptonemal complex organization(GO:0070193)
0.0 0.1 GO:0046579 positive regulation of Ras protein signal transduction(GO:0046579)
0.0 0.1 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0031264 death-inducing signaling complex(GO:0031264)
0.1 0.3 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.1 0.4 GO:0001891 phagocytic cup(GO:0001891)
0.1 0.4 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.2 GO:0071437 invadopodium(GO:0071437)
0.0 0.1 GO:0008537 proteasome activator complex(GO:0008537)
0.0 0.1 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.0 0.4 GO:0008180 COP9 signalosome(GO:0008180)
0.0 0.1 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 0.1 GO:0001652 granular component(GO:0001652)
0.0 0.1 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.0 0.1 GO:0034992 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 0.1 GO:0031904 endosome lumen(GO:0031904)
0.0 0.2 GO:0071204 histone pre-mRNA 3'end processing complex(GO:0071204)
0.0 0.1 GO:0043218 compact myelin(GO:0043218)
0.0 0.3 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.1 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 0.2 GO:0005861 troponin complex(GO:0005861)
0.0 0.1 GO:0045323 interleukin-1 receptor complex(GO:0045323)
0.0 0.0 GO:0033270 paranode region of axon(GO:0033270)
0.0 0.2 GO:0000242 pericentriolar material(GO:0000242)
0.0 0.1 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0 0.1 GO:0000791 euchromatin(GO:0000791)
0.0 0.1 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.0 0.1 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.0 0.2 GO:0005858 axonemal dynein complex(GO:0005858)
0.0 0.3 GO:0090544 BAF-type complex(GO:0090544)
0.0 0.1 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 0.0 GO:0030895 apolipoprotein B mRNA editing enzyme complex(GO:0030895)
0.0 0.1 GO:0030312 external encapsulating structure(GO:0030312)
0.0 0.0 GO:0032449 CBM complex(GO:0032449)
0.0 0.1 GO:0005826 actomyosin contractile ring(GO:0005826)
0.0 0.1 GO:0090576 RNA polymerase III transcription factor complex(GO:0090576)
0.0 0.2 GO:0045120 pronucleus(GO:0045120)
0.0 0.2 GO:0035631 CD40 receptor complex(GO:0035631)
0.0 0.0 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.0 0.0 GO:0071986 Ragulator complex(GO:0071986)
0.0 0.0 GO:0032059 bleb(GO:0032059)
0.0 0.0 GO:0031205 endoplasmic reticulum Sec complex(GO:0031205)
0.0 0.0 GO:0090533 cation-transporting ATPase complex(GO:0090533)
0.0 0.2 GO:0030914 STAGA complex(GO:0030914)
0.0 0.1 GO:0048786 presynaptic active zone(GO:0048786)
0.0 0.0 GO:0060199 clathrin-sculpted glutamate transport vesicle(GO:0060199) clathrin-sculpted glutamate transport vesicle membrane(GO:0060203)
0.0 0.1 GO:0034362 low-density lipoprotein particle(GO:0034362)
0.0 0.1 GO:0008290 F-actin capping protein complex(GO:0008290)
0.0 0.0 GO:0042583 chromaffin granule(GO:0042583) chromaffin granule membrane(GO:0042584)
0.0 0.0 GO:0030288 outer membrane-bounded periplasmic space(GO:0030288) periplasmic space(GO:0042597)
0.0 0.0 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.0 0.1 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0 0.1 GO:0090568 NuRD complex(GO:0016581) CHD-type complex(GO:0090545) nuclear transcriptional repressor complex(GO:0090568)
0.0 0.0 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.1 0.4 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.1 0.2 GO:0003726 double-stranded RNA adenosine deaminase activity(GO:0003726)
0.1 0.4 GO:0042834 peptidoglycan binding(GO:0042834)
0.1 0.2 GO:0004911 interleukin-2 receptor activity(GO:0004911)
0.1 0.2 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.0 0.1 GO:0004999 vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.0 0.4 GO:0050780 dopamine receptor binding(GO:0050780)
0.0 0.1 GO:0042156 obsolete zinc-mediated transcriptional activator activity(GO:0042156)
0.0 0.2 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.0 0.3 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.0 0.2 GO:0015925 galactosidase activity(GO:0015925)
0.0 0.1 GO:0004829 threonine-tRNA ligase activity(GO:0004829)
0.0 0.1 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.0 0.2 GO:0031014 troponin T binding(GO:0031014)
0.0 0.1 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0 0.1 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.0 0.2 GO:0003960 NADPH:quinone reductase activity(GO:0003960)
0.0 0.1 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.0 0.2 GO:0016494 C-X-C chemokine receptor activity(GO:0016494)
0.0 0.2 GO:0008432 JUN kinase binding(GO:0008432)
0.0 0.2 GO:0008266 poly(U) RNA binding(GO:0008266)
0.0 0.1 GO:0016312 inositol bisphosphate phosphatase activity(GO:0016312)
0.0 0.2 GO:0005131 growth hormone receptor binding(GO:0005131)
0.0 0.2 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.0 0.2 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
0.0 0.2 GO:0016595 glutamate binding(GO:0016595)
0.0 0.2 GO:0004983 neuropeptide Y receptor activity(GO:0004983)
0.0 0.1 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0 0.1 GO:0015252 hydrogen ion channel activity(GO:0015252)
0.0 0.1 GO:0050253 retinyl-palmitate esterase activity(GO:0050253)
0.0 0.3 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 0.1 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 0.1 GO:0048406 nerve growth factor binding(GO:0048406)
0.0 0.1 GO:0043398 HLH domain binding(GO:0043398)
0.0 0.1 GO:0009374 biotin binding(GO:0009374)
0.0 0.0 GO:0047756 chondroitin 4-sulfotransferase activity(GO:0047756)
0.0 0.1 GO:0005138 interleukin-6 receptor binding(GO:0005138)
0.0 0.1 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.0 0.2 GO:0070403 NAD+ binding(GO:0070403)
0.0 0.1 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0 0.1 GO:0052659 inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658) inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity(GO:0052659)
0.0 0.2 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0 0.1 GO:0031013 troponin I binding(GO:0031013)
0.0 0.1 GO:0071208 histone pre-mRNA DCP binding(GO:0071208)
0.0 0.1 GO:0030955 potassium ion binding(GO:0030955)
0.0 0.1 GO:0004814 arginine-tRNA ligase activity(GO:0004814)
0.0 0.2 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.0 0.1 GO:0004957 prostaglandin E receptor activity(GO:0004957)
0.0 0.1 GO:0017060 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity(GO:0017060)
0.0 0.1 GO:0017110 nucleoside-diphosphatase activity(GO:0017110)
0.0 0.1 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.0 0.2 GO:0016493 C-C chemokine receptor activity(GO:0016493)
0.0 0.1 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0 0.4 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.1 GO:0004461 lactose synthase activity(GO:0004461)
0.0 0.1 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0 0.4 GO:0004177 aminopeptidase activity(GO:0004177)
0.0 0.1 GO:0010485 H4 histone acetyltransferase activity(GO:0010485)
0.0 0.1 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.0 0.1 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 0.1 GO:0005152 interleukin-1 receptor antagonist activity(GO:0005152)
0.0 0.3 GO:0043621 protein self-association(GO:0043621)
0.0 0.0 GO:0030151 molybdenum ion binding(GO:0030151)
0.0 0.1 GO:0004704 NF-kappaB-inducing kinase activity(GO:0004704)
0.0 0.3 GO:0051117 ATPase binding(GO:0051117)
0.0 0.1 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.0 0.1 GO:0046920 alpha-(1->3)-fucosyltransferase activity(GO:0046920)
0.0 0.1 GO:0001727 lipid kinase activity(GO:0001727)
0.0 0.1 GO:0003840 gamma-glutamyltransferase activity(GO:0003840)
0.0 0.1 GO:0015379 potassium:chloride symporter activity(GO:0015379)
0.0 0.1 GO:0022897 peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897)
0.0 0.1 GO:0050786 RAGE receptor binding(GO:0050786)
0.0 0.0 GO:0004566 beta-glucuronidase activity(GO:0004566)
0.0 0.1 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.0 GO:0070061 fructose binding(GO:0070061)
0.0 0.0 GO:0004103 choline kinase activity(GO:0004103)
0.0 0.1 GO:0005521 lamin binding(GO:0005521)
0.0 0.0 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.0 0.0 GO:0052743 inositol tetrakisphosphate phosphatase activity(GO:0052743)
0.0 0.1 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
0.0 0.1 GO:0015232 heme transporter activity(GO:0015232)
0.0 0.1 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0 0.1 GO:0008494 translation activator activity(GO:0008494)
0.0 0.1 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 0.0 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.0 0.2 GO:0016411 acylglycerol O-acyltransferase activity(GO:0016411)
0.0 0.1 GO:0004308 exo-alpha-sialidase activity(GO:0004308) alpha-sialidase activity(GO:0016997)
0.0 0.3 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.0 0.1 GO:0004568 chitinase activity(GO:0004568)
0.0 0.0 GO:0046980 tapasin binding(GO:0046980)
0.0 0.0 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.0 0.1 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.0 0.2 GO:0070888 E-box binding(GO:0070888)
0.0 0.0 GO:0004505 phenylalanine 4-monooxygenase activity(GO:0004505)
0.0 0.1 GO:0015929 hexosaminidase activity(GO:0015929)
0.0 0.1 GO:0031432 titin binding(GO:0031432)
0.0 0.1 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 0.0 GO:0070996 type 1 melanocortin receptor binding(GO:0070996)
0.0 0.1 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.0 0.1 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.0 0.0 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.0 0.0 GO:0070548 L-glutamine aminotransferase activity(GO:0070548)
0.0 0.1 GO:0004985 opioid receptor activity(GO:0004985)
0.0 0.1 GO:0017108 5'-flap endonuclease activity(GO:0017108)
0.0 0.0 GO:0001758 retinal dehydrogenase activity(GO:0001758)
0.0 0.1 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity(GO:0034593)
0.0 0.1 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 0.1 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.0 0.1 GO:0003709 obsolete RNA polymerase III transcription factor activity(GO:0003709)
0.0 0.1 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 0.0 GO:0004775 succinate-CoA ligase (ADP-forming) activity(GO:0004775)
0.0 0.0 GO:0015924 mannosyl-oligosaccharide mannosidase activity(GO:0015924)
0.0 0.0 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.0 0.0 GO:0043125 ErbB-3 class receptor binding(GO:0043125)
0.0 0.0 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.0 0.0 GO:0004449 isocitrate dehydrogenase (NAD+) activity(GO:0004449)
0.0 0.0 GO:0005346 purine ribonucleotide transmembrane transporter activity(GO:0005346)
0.0 0.1 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.0 0.0 GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 1.3 PID PI3KCI PATHWAY Class I PI3K signaling events
0.0 0.2 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 0.5 PID IL27 PATHWAY IL27-mediated signaling events
0.0 0.4 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.0 0.0 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.0 0.1 PID S1P S1P4 PATHWAY S1P4 pathway
0.0 0.4 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.0 0.1 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
0.0 0.1 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 0.4 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.0 0.5 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.0 0.0 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.0 0.1 SA TRKA RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.0 0.0 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.3 PID REELIN PATHWAY Reelin signaling pathway
0.0 0.1 PID RHOA PATHWAY RhoA signaling pathway
0.0 0.2 PID ARF 3PATHWAY Arf1 pathway
0.0 0.5 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 0.1 ST PHOSPHOINOSITIDE 3 KINASE PATHWAY PI3K Pathway
0.0 0.1 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.0 0.2 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.0 0.1 PID CXCR4 PATHWAY CXCR4-mediated signaling events
0.0 0.2 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.0 0.1 ST GRANULE CELL SURVIVAL PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.0 0.0 PID IFNG PATHWAY IFN-gamma pathway
0.0 0.1 ST STAT3 PATHWAY STAT3 Pathway
0.0 0.1 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME PECAM1 INTERACTIONS Genes involved in PECAM1 interactions
0.0 0.4 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 0.4 REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 Genes involved in Signaling by activated point mutants of FGFR1
0.0 0.5 REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.0 0.7 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0 0.4 REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.0 0.2 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.0 0.1 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
0.0 0.2 REACTOME REGULATED PROTEOLYSIS OF P75NTR Genes involved in Regulated proteolysis of p75NTR
0.0 0.2 REACTOME PLATELET SENSITIZATION BY LDL Genes involved in Platelet sensitization by LDL
0.0 0.7 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.0 REACTOME SIGNALING BY FGFR3 MUTANTS Genes involved in Signaling by FGFR3 mutants
0.0 0.1 REACTOME ACTIVATION OF NF KAPPAB IN B CELLS Genes involved in Activation of NF-kappaB in B Cells
0.0 0.2 REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS Genes involved in CREB phosphorylation through the activation of Ras
0.0 0.0 REACTOME G PROTEIN ACTIVATION Genes involved in G-protein activation
0.0 0.4 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.2 REACTOME GROWTH HORMONE RECEPTOR SIGNALING Genes involved in Growth hormone receptor signaling
0.0 0.3 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 0.2 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 0.0 REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION Genes involved in activated TAK1 mediates p38 MAPK activation
0.0 0.1 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.0 0.1 REACTOME IL 2 SIGNALING Genes involved in Interleukin-2 signaling
0.0 0.2 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.1 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.0 0.2 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 0.1 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.0 0.2 REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI Genes involved in RIP-mediated NFkB activation via DAI
0.0 0.1 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 0.7 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 0.0 REACTOME OPSINS Genes involved in Opsins
0.0 0.1 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 0.0 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.0 0.0 REACTOME ANTIGEN PROCESSING CROSS PRESENTATION Genes involved in Antigen processing-Cross presentation
0.0 0.1 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.1 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 0.3 REACTOME TCR SIGNALING Genes involved in TCR signaling