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ENCODE: H3K4me1 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for NKX2-1

Z-value: 1.29

Motif logo

Transcription factors associated with NKX2-1

Gene Symbol	Gene ID	Gene Info
NKX2-1 Ensembl NCBI GeneCards UniProt	ENSG00000136352.13	NKX2-1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
NKX2-1	chr14_36990374_36990607	136	0.943212	0.64	6.5e-02	Click!
NKX2-1	chr14_36989210_36989422	23	0.943031	0.48	1.9e-01	Click!
NKX2-1	chr14_36990794_36990945	515	0.724164	0.47	2.1e-01	Click!
NKX2-1	chr14_36989834_36989985	245	0.877429	0.28	4.6e-01	Click!
NKX2-1	chr14_36988822_36989041	33	0.881591	-0.13	7.4e-01	Click!

Activity of the NKX2-1 motif across conditions

Conditions sorted by the z-value of the NKX2-1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr3_71591322_71591805	0.39	ENSG00000221264	.	323	0.83
chr20_19739352_19739650	0.35	AL121761.2	Uncharacterized protein	822	0.67
chr14_78668483_78668908	0.34	ENSG00000199454	.	24431	0.22
chr9_114554047_114554198	0.33	C9orf84	chromosome 9 open reading frame 84	3090	0.29
chr7_20254919_20255070	0.32	MACC1	metastasis associated in colon cancer 1	2019	0.4
chr17_45334887_45335241	0.31	ENSG00000238419	.	1722	0.26
chr15_99344237_99344527	0.31	ENSG00000264480	.	16727	0.24
chr6_35393359_35394053	0.31	FANCE	Fanconi anemia, complementation group E	26432	0.15
chr11_92441050_92441201	0.30	ENSG00000239086	.	21456	0.24
chr18_24155354_24155632	0.29	ENSG00000252846	.	11269	0.22
chr4_157888355_157888628	0.29	PDGFC	platelet derived growth factor C	3564	0.27
chr8_23397789_23397996	0.29	SLC25A37	solute carrier family 25 (mitochondrial iron transporter), member 37	11319	0.16
chr20_1460805_1460958	0.28	ENSG00000266085	.	8314	0.14
chr7_72974638_72974971	0.28	BCL7B	B-cell CLL/lymphoma 7B	2472	0.22
chr2_65087186_65087345	0.28	ENSG00000199964	.	25974	0.15
chr1_86038271_86038452	0.28	DDAH1	dimethylarginine dimethylaminohydrolase 1	5572	0.2
chr11_9778479_9778630	0.27	SBF2-AS1	SBF2 antisense RNA 1	1285	0.44
chr17_42425530_42425884	0.27	GRN	granulin	2200	0.16
chr7_152010807_152011572	0.27	KMT2C	lysine (K)-specific methyltransferase 2C	66085	0.11
chr9_33354750_33355149	0.26	ENSG00000200544	.	2077	0.27
chr11_75735939_75736309	0.26	UVRAG	UV radiation resistance associated	41644	0.15
chr17_438204_438582	0.26	RP5-1029F21.4		12013	0.17
chr17_40562098_40562486	0.26	ENSG00000221020	.	11265	0.11
chr7_134938605_134938973	0.26	STRA8	stimulated by retinoic acid 8	22058	0.17
chr12_54655635_54656068	0.26	RP11-968A15.2		548	0.55
chr21_40683413_40684326	0.26	BRWD1	bromodomain and WD repeat domain containing 1	1627	0.24
chr2_69309476_69309763	0.26	ANTXR1	anthrax toxin receptor 1	6884	0.22
chr1_109931574_109931829	0.26	SORT1	sortilin 1	4278	0.19
chr5_149189745_149189896	0.25	PPARGC1B	peroxisome proliferator-activated receptor gamma, coactivator 1 beta	22758	0.18
chr1_9145986_9146241	0.25	SLC2A5	solute carrier family 2 (facilitated glucose/fructose transporter), member 5	2389	0.23
chr5_126898357_126898508	0.25	PRRC1	proline-rich coiled-coil 1	45084	0.18
chr11_74347920_74348157	0.25	POLD3	polymerase (DNA-directed), delta 3, accessory subunit	1621	0.37
chr5_72511846_72512133	0.25	TMEM174	transmembrane protein 174	42967	0.14
chr6_147234985_147235152	0.25	STXBP5-AS1	STXBP5 antisense RNA 1	1953	0.49
chr8_26123678_26123924	0.24	PPP2R2A	protein phosphatase 2, regulatory subunit B, alpha	25206	0.23
chr17_42872109_42872587	0.24	GJC1	gap junction protein, gamma 1, 45kDa	9986	0.14
chr1_235104740_235105149	0.24	ENSG00000239690	.	65011	0.12
chr2_219597745_219597964	0.24	TTLL4	tubulin tyrosine ligase-like family, member 4	4443	0.16
chr1_10958313_10958477	0.24	C1orf127	chromosome 1 open reading frame 127	49532	0.12
chr15_92034111_92034262	0.24	SV2B	synaptic vesicle glycoprotein 2B	265086	0.02
chr5_171530999_171531150	0.24	ENSG00000266671	.	23094	0.19
chr1_95119284_95119435	0.24	ENSG00000263526	.	92097	0.08
chr10_81109102_81109275	0.24	PPIF	peptidylprolyl isomerase F	1774	0.38
chr22_19074070_19074357	0.24	AC004471.9		34829	0.09
chr2_38404404_38404678	0.24	ENSG00000199603	.	29984	0.19
chr5_138753028_138753179	0.23	DNAJC18	DnaJ (Hsp40) homolog, subfamily C, member 18	7634	0.1
chr19_1796326_1796477	0.23	ATP8B3	ATPase, aminophospholipid transporter, class I, type 8B, member 3	15222	0.09
chr11_34443753_34443957	0.23	CAT	catalase	16617	0.22
chr12_32655690_32655927	0.23	FGD4	FYVE, RhoGEF and PH domain containing 4	657	0.77
chr17_54236463_54236752	0.23	ANKFN1	ankyrin-repeat and fibronectin type III domain containing 1	5736	0.33
chr1_29575738_29576111	0.23	ENSG00000221550	.	4271	0.18
chr1_28879167_28879368	0.23	TRNAU1AP	tRNA selenocysteine 1 associated protein 1	330	0.8
chr4_140099443_140099664	0.23	ELF2	E74-like factor 2 (ets domain transcription factor)	1181	0.4
chr17_71064314_71064465	0.23	SLC39A11	solute carrier family 39, member 11	21514	0.23
chr16_81534432_81534869	0.23	CMIP	c-Maf inducing protein	5696	0.3
chr1_49083295_49083518	0.23	AGBL4	ATP/GTP binding protein-like 4	63168	0.14
chr3_171579285_171579488	0.23	TMEM212	transmembrane protein 212	18080	0.18
chr6_142699159_142699742	0.23	GPR126	G protein-coupled receptor 126	11999	0.29
chr12_64261703_64261854	0.23	RP11-274J7.2		10789	0.17
chr6_37023589_37023822	0.22	COX6A1P2	cytochrome c oxidase subunit VIa polypeptide 1 pseudogene 2	11098	0.2
chr1_235035137_235035288	0.22	ENSG00000239690	.	4721	0.3
chr5_146889795_146890041	0.22	DPYSL3	dihydropyrimidinase-like 3	299	0.94
chr8_130691624_130691889	0.22	GSDMC	gasdermin C	107378	0.06
chr15_66910964_66911559	0.22	RP11-321F6.1	HCG2003567; Uncharacterized protein	36733	0.12
chr20_11790867_11791018	0.22	ENSG00000222281	.	8797	0.29
chr6_7130248_7130425	0.22	RREB1	ras responsive element binding protein 1	9142	0.22
chr1_175560414_175560565	0.22	TNR-IT1	TNR intronic transcript 1 (non-protein coding)	34535	0.23
chr10_54286609_54286760	0.22	RP11-556E13.1		34181	0.24
chr6_109063657_109063820	0.22	FOXO3	forkhead box O3	86189	0.09
chr1_61650059_61650312	0.21	RP4-802A10.1		59780	0.14
chr7_93868977_93869198	0.21	COL1A2	collagen, type I, alpha 2	154786	0.04
chr4_120024366_120024563	0.21	MYOZ2	myozenin 2	32475	0.19
chr5_133837543_133837821	0.21	ENSG00000207222	.	1707	0.32
chr11_10350303_10350459	0.21	AMPD3	adenosine monophosphate deaminase 3	11163	0.16
chr7_127858076_127858330	0.21	ENSG00000207705	.	10279	0.19
chr1_165831561_165831763	0.21	UCK2	uridine-cytidine kinase 2	33145	0.15
chr9_130302299_130302610	0.21	FAM129B	family with sequence similarity 129, member B	28913	0.13
chr12_3226541_3226699	0.21	TSPAN9-IT1	TSPAN9 intronic transcript 1 (non-protein coding)	32343	0.17
chr17_33568770_33569141	0.21	RP11-799D4.4		1027	0.35
chr2_153277819_153278036	0.20	FMNL2	formin-like 2	86176	0.1
chr2_47262098_47262362	0.20	AC093732.1		5433	0.21
chr1_208381209_208381624	0.20	PLXNA2	plexin A2	36249	0.24
chr13_40684091_40684242	0.20	ENSG00000207458	.	116798	0.07
chr3_172036187_172036338	0.20	AC092964.1	Uncharacterized protein	2044	0.36
chr1_95296795_95296987	0.20	SLC44A3	solute carrier family 44, member 3	10685	0.21
chr18_9704973_9705544	0.20	RAB31	RAB31, member RAS oncogene family	2904	0.31
chr9_111826033_111826184	0.20	ENSG00000207698	.	17530	0.14
chr2_43191638_43192077	0.20	ENSG00000207087	.	126775	0.05
chr12_49626134_49626329	0.20	TUBA1C	tubulin, alpha 1c	4522	0.14
chr16_85244563_85244846	0.20	CTC-786C10.1		39822	0.17
chr8_57595398_57595566	0.20	RP11-17A4.2		193825	0.03
chr17_38171762_38172321	0.20	CSF3	colony stimulating factor 3 (granulocyte)	301	0.83
chr14_89824555_89824893	0.20	RP11-356K23.2		3320	0.22
chr1_157373506_157373754	0.20	FCRL5	Fc receptor-like 5	148550	0.04
chr7_42277787_42277938	0.20	GLI3	GLI family zinc finger 3	1204	0.66
chr3_134317870_134318272	0.20	EPHB1	EPH receptor B1	16136	0.21
chr17_1548050_1548254	0.20	SCARF1	scavenger receptor class F, member 1	886	0.4
chr5_139727515_139728049	0.19	HBEGF	heparin-binding EGF-like growth factor	1566	0.26
chr13_107137363_107137514	0.19	EFNB2	ephrin-B2	50024	0.17
chr3_185479152_185479525	0.19	ENSG00000265470	.	6354	0.24
chr17_43253672_43253834	0.19	RP13-890H12.2		4802	0.11
chr9_119714349_119714500	0.19	ENSG00000265662	.	146862	0.04
chr15_99226253_99226598	0.19	IGF1R	insulin-like growth factor 1 receptor	24635	0.2
chr7_16697056_16697503	0.19	BZW2	basic leucine zipper and W2 domains 2	3569	0.24
chr14_21574185_21574440	0.19	ZNF219	zinc finger protein 219	1431	0.25
chr1_178911938_178912211	0.19	RALGPS2	Ral GEF with PH domain and SH3 binding motif 2	56860	0.12
chr5_124201652_124202095	0.19	ZNF608	zinc finger protein 608	117373	0.06
chr2_153324557_153324708	0.19	FMNL2	formin-like 2	132881	0.05
chr5_14154020_14154339	0.19	TRIO	trio Rho guanine nucleotide exchange factor	10350	0.32
chr1_77748942_77749155	0.19	AK5	adenylate kinase 5	284	0.93
chr7_2680395_2680583	0.19	TTYH3	tweety family member 3	4677	0.21
chr2_70699360_70699623	0.19	TGFA-IT1	TGFA intronic transcript 1 (non-protein coding)	3864	0.2
chr20_44538606_44538964	0.19	PLTP	phospholipid transfer protein	791	0.42
chr2_172380569_172381265	0.19	CYBRD1	cytochrome b reductase 1	1328	0.53
chr11_88256352_88256580	0.19	GRM5-AS1	GRM5 antisense RNA 1	11550	0.29
chr6_64516560_64517136	0.19	RP11-59D5__B.2		119	0.98
chr12_22436696_22436847	0.19	ST8SIA1	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	34791	0.21
chr6_137587453_137587604	0.19	IFNGR1	interferon gamma receptor 1	46942	0.17
chr10_33653913_33654108	0.18	NRP1	neuropilin 1	28820	0.23
chr1_242494290_242494441	0.18	PLD5	phospholipase D family, member 5	118362	0.06
chr15_75418307_75418680	0.18	ENSG00000252722	.	4486	0.2
chr2_87016233_87016699	0.18	CD8A	CD8a molecule	1482	0.41
chr2_14775111_14775564	0.18	AC011897.1	Uncharacterized protein	122	0.97
chr18_10594479_10594630	0.18	RP11-856M7.1		67376	0.1
chr2_235933793_235934065	0.18	SH3BP4	SH3-domain binding protein 4	30445	0.26
chr4_143883337_143883532	0.18	INPP4B	inositol polyphosphate-4-phosphatase, type II, 105kDa	114849	0.07
chr8_126510706_126510857	0.18	ENSG00000266452	.	53974	0.15
chr21_39875635_39875873	0.18	ERG	v-ets avian erythroblastosis virus E26 oncogene homolog	5347	0.34
chr9_93959973_93960173	0.18	AUH	AU RNA binding protein/enoyl-CoA hydratase	164104	0.04
chr4_40623166_40623743	0.18	RBM47	RNA binding motif protein 47	8427	0.27
chr1_31350251_31350496	0.18	SDC3	syndecan 3	1214	0.42
chr2_20311558_20311709	0.18	RP11-644K8.1		59738	0.09
chr6_106329312_106329592	0.18	ENSG00000200198	.	22796	0.27
chr12_1702754_1702905	0.18	FBXL14	F-box and leucine-rich repeat protein 14	502	0.82
chr8_29420044_29420195	0.18	RP4-676L2.1		209432	0.02
chr1_49243286_49243470	0.18	BEND5	BEN domain containing 5	788	0.77
chr7_23503511_23503662	0.18	IGF2BP3	insulin-like growth factor 2 mRNA binding protein 3	6500	0.18
chr7_100781001_100781597	0.18	SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	10920	0.1
chr8_29492885_29493176	0.18	RP4-676L2.1		282343	0.01
chr20_17972943_17973101	0.18	MGME1	mitochondrial genome maintenance exonuclease 1	23264	0.13
chr7_41727697_41728013	0.18	INHBA-AS1	INHBA antisense RNA 1	5659	0.22
chr2_197853357_197853508	0.18	ANKRD44	ankyrin repeat domain 44	11794	0.26
chr12_50447359_50447620	0.18	ASIC1	acid-sensing (proton-gated) ion channel 1	3842	0.15
chr2_204513967_204514120	0.17	CD28	CD28 molecule	57155	0.14
chr1_28653417_28653596	0.17	MED18	mediator complex subunit 18	2043	0.28
chr7_99970452_99970794	0.17	PILRA	paired immunoglobin-like type 2 receptor alpha	445	0.66
chr7_138664896_138665077	0.17	KIAA1549	KIAA1549	1078	0.59
chr11_63388800_63389118	0.17	RP11-697H9.3		5179	0.15
chr20_52355039_52355190	0.17	ENSG00000238468	.	69817	0.12
chr19_41936846_41937128	0.17	B3GNT8	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8	2352	0.14
chr6_47276047_47276198	0.17	TNFRSF21	tumor necrosis factor receptor superfamily, member 21	1519	0.54
chr1_56991345_56991645	0.17	PPAP2B	phosphatidic acid phosphatase type 2B	53746	0.16
chr1_61718931_61719082	0.17	NFIA	nuclear factor I/A	99116	0.08
chr7_22899009_22899286	0.17	ENSG00000221740	.	2915	0.31
chr22_41762881_41763188	0.17	TEF	thyrotrophic embryonic factor	303	0.87
chr3_184355166_184355357	0.17	MAGEF1	melanoma antigen family F, 1	74575	0.09
chr2_70368551_70369209	0.17	C2orf42	chromosome 2 open reading frame 42	40247	0.11
chr16_74777388_74777539	0.17	FA2H	fatty acid 2-hydroxylase	2296	0.28
chr21_40211048_40211199	0.17	ETS2	v-ets avian erythroblastosis virus E26 oncogene homolog 2	29563	0.22
chr5_6705329_6705555	0.17	PAPD7	PAP associated domain containing 7	9276	0.26
chr8_6372842_6373023	0.17	ANGPT2	angiopoietin 2	47633	0.16
chr16_1742334_1742485	0.17	HN1L	hematological and neurological expressed 1-like	6908	0.09
chr4_15452943_15453218	0.17	CC2D2A	coiled-coil and C2 domain containing 2A	18409	0.16
chr6_56820926_56821126	0.17	BEND6	BEN domain containing 6	856	0.52
chr5_37249784_37249952	0.17	C5orf42	chromosome 5 open reading frame 42	338	0.89
chr7_134477490_134477641	0.17	CALD1	caldesmon 1	13136	0.28
chr18_53156534_53156869	0.17	RP11-619L19.2		2705	0.26
chr20_52556645_52557141	0.17	AC005220.3		194	0.96
chr11_119563178_119563367	0.17	PVRL1	poliovirus receptor-related 1 (herpesvirus entry mediator C)	35991	0.13
chr2_208734859_208735279	0.17	AC083900.1		430	0.86
chr5_102294298_102294449	0.17	PAM	peptidylglycine alpha-amidating monooxygenase	9092	0.31
chr1_46598395_46598546	0.17	PIK3R3	phosphoinositide-3-kinase, regulatory subunit 3 (gamma)	4	0.96
chr3_185463874_185464186	0.17	ENSG00000265470	.	21662	0.19
chr8_124642901_124643058	0.17	CTD-2552K11.2		16514	0.17
chr3_25515158_25515309	0.17	RARB	retinoic acid receptor, beta	15432	0.26
chr11_103553300_103553882	0.17	ENSG00000264200	.	167043	0.04
chr6_37279555_37279706	0.17	RNF8	ring finger protein 8, E3 ubiquitin protein ligase	42118	0.11
chr6_150209605_150209756	0.17	RAET1E-AS1	RAET1E antisense RNA 1	1559	0.24
chr10_81104566_81104717	0.17	PPIF	peptidylprolyl isomerase F	2586	0.3
chr10_116474114_116474265	0.17	ABLIM1	actin binding LIM protein 1	29775	0.21
chr10_80328339_80328521	0.17	ENSG00000223243	.	181929	0.03
chr7_115995833_115995984	0.17	ENSG00000216076	.	9910	0.21
chr22_44704942_44705093	0.17	KIAA1644	KIAA1644	3714	0.31
chrX_48858096_48858311	0.17	GRIPAP1	GRIP1 associated protein 1	442	0.68
chr20_61334808_61334959	0.17	NTSR1	neurotensin receptor 1 (high affinity)	5306	0.14
chr3_105089117_105089308	0.17	ALCAM	activated leukocyte cell adhesion molecule	3025	0.42
chr8_23610347_23610498	0.17	ENSG00000216123	.	15736	0.17
chr7_5674087_5674709	0.17	FSCN1	fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)	40081	0.12
chr8_122176471_122176664	0.17	ENSG00000221644	.	22565	0.27
chr9_96263559_96263710	0.17	FAM120A	family with sequence similarity 120A	30803	0.14
chr16_74764278_74764475	0.17	FA2H	fatty acid 2-hydroxylase	10791	0.18
chr4_140958813_140959347	0.16	RP11-392B6.1		90089	0.09
chr10_21812025_21812176	0.16	SKIDA1	SKI/DACH domain containing 1	2511	0.2
chr17_72747231_72747488	0.16	MIR3615	microRNA 3615	2308	0.15
chr10_80850413_80850863	0.16	ZMIZ1	zinc finger, MIZ-type containing 1	21846	0.22
chr16_66521179_66521358	0.16	AC132186.1	CDNA FLJ27243 fis, clone SYN08134; Uncharacterized protein	1521	0.27
chr9_75080014_75080202	0.16	TMC1	transmembrane channel-like 1	56609	0.14
chr6_123112103_123112308	0.16	SMPDL3A	sphingomyelin phosphodiesterase, acid-like 3A	1734	0.38
chr1_33462562_33463087	0.16	RP1-117O3.2		10148	0.14
chr16_12707264_12707435	0.16	CTD-3037G24.3		2448	0.33

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX2-1

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View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0060831	smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:0060831)
0.1	0.2	GO:0032467	positive regulation of cytokinesis(GO:0032467)
0.1	0.2	GO:0042663	endodermal cell fate specification(GO:0001714) regulation of endodermal cell fate specification(GO:0042663) regulation of endodermal cell differentiation(GO:1903224)
0.0	0.3	GO:0007185	transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0	0.1	GO:0001996	positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996)
0.0	0.1	GO:0051573	negative regulation of histone H3-K9 methylation(GO:0051573)
0.0	0.1	GO:0071294	cellular response to zinc ion(GO:0071294)
0.0	0.1	GO:0045578	negative regulation of B cell differentiation(GO:0045578)
0.0	0.1	GO:0034625	fatty acid elongation, monounsaturated fatty acid(GO:0034625)
0.0	0.2	GO:0030321	transepithelial chloride transport(GO:0030321)
0.0	0.1	GO:0045425	positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process(GO:0045425)
0.0	0.0	GO:0060913	cardiac cell fate determination(GO:0060913)
0.0	0.1	GO:0051771	negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771)
0.0	0.1	GO:0032509	endosome transport via multivesicular body sorting pathway(GO:0032509)
0.0	0.2	GO:0006686	sphingomyelin biosynthetic process(GO:0006686)
0.0	0.1	GO:0072367	regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367)
0.0	0.0	GO:0051570	regulation of histone H3-K9 methylation(GO:0051570)
0.0	0.3	GO:0031274	pseudopodium assembly(GO:0031269) regulation of pseudopodium assembly(GO:0031272) positive regulation of pseudopodium assembly(GO:0031274)
0.0	0.1	GO:0003308	negative regulation of Wnt signaling pathway involved in heart development(GO:0003308)
0.0	0.0	GO:0031061	negative regulation of histone methylation(GO:0031061)
0.0	0.1	GO:0009448	gamma-aminobutyric acid metabolic process(GO:0009448)
0.0	0.1	GO:0009189	deoxyribonucleoside diphosphate biosynthetic process(GO:0009189)
0.0	0.0	GO:0060084	synaptic transmission involved in micturition(GO:0060084)
0.0	0.1	GO:0001992	regulation of systemic arterial blood pressure by vasopressin(GO:0001992)
0.0	0.1	GO:0072201	negative regulation of mesenchymal cell proliferation(GO:0072201)
0.0	0.0	GO:0070208	protein heterotrimerization(GO:0070208)
0.0	0.1	GO:0042271	susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.0	0.2	GO:0048755	branching morphogenesis of a nerve(GO:0048755)
0.0	0.2	GO:0001514	selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.0	0.1	GO:0048003	antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003)
0.0	0.1	GO:0070634	transepithelial ammonium transport(GO:0070634)
0.0	0.1	GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway(GO:0010803)
0.0	0.1	GO:0045715	negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715)
0.0	0.1	GO:0045091	regulation of single stranded viral RNA replication via double stranded DNA intermediate(GO:0045091)
0.0	0.1	GO:0042670	retinal cone cell differentiation(GO:0042670) retinal cone cell development(GO:0046549)
0.0	0.1	GO:0070295	renal water absorption(GO:0070295)
0.0	0.1	GO:0007028	cytoplasm organization(GO:0007028)
0.0	0.1	GO:0048702	embryonic neurocranium morphogenesis(GO:0048702)
0.0	0.1	GO:0060676	ureteric bud formation(GO:0060676)
0.0	0.1	GO:0033008	positive regulation of mast cell activation involved in immune response(GO:0033008) positive regulation of leukocyte degranulation(GO:0043302) positive regulation of mast cell degranulation(GO:0043306)
0.0	0.1	GO:0032497	detection of lipopolysaccharide(GO:0032497)
0.0	0.1	GO:0009405	pathogenesis(GO:0009405)
0.0	0.1	GO:0044803	multi-organism membrane organization(GO:0044803)
0.0	0.1	GO:0060251	regulation of glial cell proliferation(GO:0060251)
0.0	0.1	GO:0019985	translesion synthesis(GO:0019985)
0.0	0.1	GO:0070272	proton-transporting ATP synthase complex assembly(GO:0043461) proton-transporting ATP synthase complex biogenesis(GO:0070272)
0.0	0.0	GO:0001302	replicative cell aging(GO:0001302)
0.0	0.1	GO:0015840	urea transport(GO:0015840)
0.0	0.1	GO:0032959	inositol trisphosphate biosynthetic process(GO:0032959)
0.0	0.0	GO:0048807	female genitalia morphogenesis(GO:0048807)
0.0	0.0	GO:0032928	regulation of superoxide anion generation(GO:0032928)
0.0	0.1	GO:0051124	synaptic growth at neuromuscular junction(GO:0051124)
0.0	0.1	GO:0003321	positive regulation of blood pressure by epinephrine-norepinephrine(GO:0003321)
0.0	0.1	GO:0030538	embryonic genitalia morphogenesis(GO:0030538)
0.0	0.1	GO:0006189	'de novo' IMP biosynthetic process(GO:0006189)
0.0	0.1	GO:0006562	proline catabolic process(GO:0006562)
0.0	0.2	GO:0030502	negative regulation of bone mineralization(GO:0030502)
0.0	0.1	GO:0060028	convergent extension involved in axis elongation(GO:0060028)
0.0	0.1	GO:0006663	platelet activating factor biosynthetic process(GO:0006663)
0.0	0.1	GO:0043276	anoikis(GO:0043276)
0.0	0.1	GO:0003161	cardiac conduction system development(GO:0003161)
0.0	0.1	GO:0032780	negative regulation of ATPase activity(GO:0032780)
0.0	0.1	GO:0015959	diadenosine polyphosphate metabolic process(GO:0015959)
0.0	0.1	GO:0045079	negative regulation of chemokine production(GO:0032682) negative regulation of chemokine biosynthetic process(GO:0045079)
0.0	0.0	GO:0010834	obsolete telomere maintenance via telomere shortening(GO:0010834)
0.0	0.1	GO:0007171	activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.0	0.1	GO:0060907	positive regulation of macrophage cytokine production(GO:0060907)
0.0	0.1	GO:0071731	response to nitric oxide(GO:0071731)
0.0	0.0	GO:0070874	negative regulation of glycogen metabolic process(GO:0070874)
0.0	0.1	GO:0032328	alanine transport(GO:0032328)
0.0	0.0	GO:0048791	calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0	0.1	GO:0035610	C-terminal protein deglutamylation(GO:0035609) protein side chain deglutamylation(GO:0035610)
0.0	0.0	GO:0051547	regulation of keratinocyte migration(GO:0051547) positive regulation of keratinocyte migration(GO:0051549)
0.0	0.2	GO:0035413	positive regulation of catenin import into nucleus(GO:0035413)
0.0	0.1	GO:0051873	disruption by host of symbiont cells(GO:0051852) killing by host of symbiont cells(GO:0051873)
0.0	0.1	GO:0006065	UDP-glucuronate biosynthetic process(GO:0006065)
0.0	0.1	GO:0060433	bronchus development(GO:0060433)
0.0	0.1	GO:0090084	negative regulation of inclusion body assembly(GO:0090084)
0.0	0.5	GO:0030574	collagen catabolic process(GO:0030574)
0.0	0.1	GO:0046618	drug export(GO:0046618)
0.0	0.1	GO:0005981	regulation of glycogen catabolic process(GO:0005981)
0.0	0.2	GO:0000052	citrulline metabolic process(GO:0000052)
0.0	0.1	GO:0009249	protein lipoylation(GO:0009249)
0.0	0.1	GO:0071425	hematopoietic stem cell proliferation(GO:0071425)
0.0	0.1	GO:0009414	response to water deprivation(GO:0009414)
0.0	0.1	GO:0021535	cell migration in hindbrain(GO:0021535)
0.0	0.1	GO:0010842	retina layer formation(GO:0010842)
0.0	0.1	GO:0006296	nucleotide-excision repair, DNA incision, 5'-to lesion(GO:0006296)
0.0	0.1	GO:0031641	regulation of myelination(GO:0031641)
0.0	0.0	GO:0032277	negative regulation of gonadotropin secretion(GO:0032277)
0.0	0.0	GO:0015691	cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
0.0	0.2	GO:0000731	DNA synthesis involved in DNA repair(GO:0000731)
0.0	0.2	GO:0009629	response to gravity(GO:0009629)
0.0	0.1	GO:0071157	negative regulation of cell cycle arrest(GO:0071157)
0.0	0.1	GO:0044320	cellular response to leptin stimulus(GO:0044320) response to leptin(GO:0044321)
0.0	0.0	GO:0032957	inositol trisphosphate metabolic process(GO:0032957)
0.0	0.1	GO:0060665	regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.0	0.1	GO:0060406	positive regulation of penile erection(GO:0060406)
0.0	0.1	GO:0045112	integrin biosynthetic process(GO:0045112)
0.0	0.1	GO:0061303	cornea development in camera-type eye(GO:0061303)
0.0	0.1	GO:0008215	spermine metabolic process(GO:0008215)
0.0	0.1	GO:1900115	sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.0	0.1	GO:0060666	dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.0	0.2	GO:0021952	central nervous system projection neuron axonogenesis(GO:0021952)
0.0	0.1	GO:0090267	positive regulation of spindle checkpoint(GO:0090232) regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267) positive regulation of cell cycle checkpoint(GO:1901978) regulation of mitotic spindle checkpoint(GO:1903504)
0.0	0.1	GO:0043569	negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.0	0.1	GO:0060259	regulation of feeding behavior(GO:0060259)
0.0	0.1	GO:0035511	oxidative DNA demethylation(GO:0035511)
0.0	0.1	GO:0072385	minus-end-directed organelle transport along microtubule(GO:0072385)
0.0	0.0	GO:0061081	positive regulation of myeloid leukocyte cytokine production involved in immune response(GO:0061081)
0.0	0.1	GO:0050703	interleukin-1 alpha secretion(GO:0050703)
0.0	0.1	GO:0061088	regulation of sequestering of zinc ion(GO:0061088)
0.0	0.1	GO:0007216	G-protein coupled glutamate receptor signaling pathway(GO:0007216)
0.0	0.1	GO:0045767	obsolete regulation of anti-apoptosis(GO:0045767)
0.0	0.0	GO:0007412	axon target recognition(GO:0007412)
0.0	0.1	GO:0006516	glycoprotein catabolic process(GO:0006516)
0.0	0.0	GO:0071605	monocyte chemotactic protein-1 production(GO:0071605) regulation of monocyte chemotactic protein-1 production(GO:0071637)
0.0	0.0	GO:2000095	regulation of non-canonical Wnt signaling pathway(GO:2000050) regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000095)
0.0	0.1	GO:0006420	arginyl-tRNA aminoacylation(GO:0006420)
0.0	0.1	GO:0070572	positive regulation of axon regeneration(GO:0048680) positive regulation of neuron projection regeneration(GO:0070572)
0.0	0.0	GO:0048368	lateral mesoderm development(GO:0048368)
0.0	0.1	GO:0060014	granulosa cell differentiation(GO:0060014)
0.0	0.0	GO:0031268	pseudopodium organization(GO:0031268)
0.0	0.1	GO:0032347	regulation of ketone biosynthetic process(GO:0010566) regulation of aldosterone metabolic process(GO:0032344) regulation of aldosterone biosynthetic process(GO:0032347)
0.0	0.1	GO:0043589	skin morphogenesis(GO:0043589)
0.0	0.0	GO:0009756	carbohydrate mediated signaling(GO:0009756)
0.0	0.1	GO:0055075	potassium ion homeostasis(GO:0055075)
0.0	0.1	GO:0045793	positive regulation of cell size(GO:0045793)
0.0	0.1	GO:0030644	cellular chloride ion homeostasis(GO:0030644) chloride ion homeostasis(GO:0055064)
0.0	0.0	GO:0090047	obsolete positive regulation of transcription regulator activity(GO:0090047)
0.0	0.1	GO:0006975	DNA damage induced protein phosphorylation(GO:0006975)
0.0	0.0	GO:0071025	RNA surveillance(GO:0071025) nuclear RNA surveillance(GO:0071027) nuclear mRNA surveillance(GO:0071028)
0.0	0.0	GO:0019471	peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) 4-hydroxyproline metabolic process(GO:0019471) peptidyl-proline hydroxylation(GO:0019511)
0.0	0.0	GO:0071043	CUT catabolic process(GO:0071034) CUT metabolic process(GO:0071043)
0.0	0.0	GO:0019800	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0	0.0	GO:0048170	positive regulation of long-term neuronal synaptic plasticity(GO:0048170)
0.0	0.1	GO:0070373	negative regulation of ERK1 and ERK2 cascade(GO:0070373)
0.0	0.0	GO:0061298	retina vasculature development in camera-type eye(GO:0061298) retina vasculature morphogenesis in camera-type eye(GO:0061299)
0.0	0.1	GO:0033600	negative regulation of mammary gland epithelial cell proliferation(GO:0033600)
0.0	0.1	GO:0033962	cytoplasmic mRNA processing body assembly(GO:0033962)
0.0	0.0	GO:1902339	apoptotic process involved in mammary gland involution(GO:0060057) positive regulation of apoptotic process involved in mammary gland involution(GO:0060058) positive regulation of apoptotic process involved in morphogenesis(GO:1902339) regulation of mammary gland involution(GO:1903519) positive regulation of mammary gland involution(GO:1903521) positive regulation of apoptotic process involved in development(GO:1904747)
0.0	0.1	GO:0017085	response to insecticide(GO:0017085)
0.0	0.0	GO:0048312	intracellular distribution of mitochondria(GO:0048312)
0.0	0.1	GO:0006108	malate metabolic process(GO:0006108)
0.0	0.1	GO:0008655	pyrimidine-containing compound salvage(GO:0008655) pyrimidine nucleoside salvage(GO:0043097)
0.0	0.0	GO:0017121	phospholipid scrambling(GO:0017121)
0.0	0.0	GO:0045906	negative regulation of vasoconstriction(GO:0045906)
0.0	0.0	GO:0018242	protein O-linked glycosylation via serine(GO:0018242) protein O-linked glycosylation via threonine(GO:0018243)
0.0	0.1	GO:0046855	phosphorylated carbohydrate dephosphorylation(GO:0046838) inositol phosphate dephosphorylation(GO:0046855) inositol phosphate catabolic process(GO:0071545)
0.0	0.1	GO:0034446	substrate adhesion-dependent cell spreading(GO:0034446)
0.0	0.1	GO:0009223	pyrimidine deoxyribonucleotide catabolic process(GO:0009223)
0.0	0.0	GO:0019805	quinolinate biosynthetic process(GO:0019805)
0.0	0.1	GO:0006853	carnitine shuttle(GO:0006853) carnitine transmembrane transport(GO:1902603)
0.0	0.2	GO:0045600	positive regulation of fat cell differentiation(GO:0045600)
0.0	0.0	GO:0043490	malate-aspartate shuttle(GO:0043490)
0.0	0.1	GO:0071305	cellular response to vitamin D(GO:0071305)
0.0	0.1	GO:0009649	entrainment of circadian clock(GO:0009649)
0.0	0.0	GO:0006419	alanyl-tRNA aminoacylation(GO:0006419)
0.0	0.0	GO:0046607	positive regulation of centrosome cycle(GO:0046607)
0.0	0.1	GO:0006828	manganese ion transport(GO:0006828)
0.0	0.0	GO:0006552	leucine catabolic process(GO:0006552)
0.0	0.1	GO:0033522	histone H2A ubiquitination(GO:0033522)
0.0	0.0	GO:0007262	STAT protein import into nucleus(GO:0007262)
0.0	0.1	GO:0007090	obsolete regulation of S phase of mitotic cell cycle(GO:0007090)
0.0	0.0	GO:0021555	midbrain-hindbrain boundary morphogenesis(GO:0021555)
0.0	0.0	GO:0060999	positive regulation of dendritic spine development(GO:0060999)
0.0	0.0	GO:0033160	positive regulation of protein import into nucleus, translocation(GO:0033160)
0.0	0.1	GO:0006654	phosphatidic acid biosynthetic process(GO:0006654)
0.0	0.0	GO:0006011	UDP-glucose metabolic process(GO:0006011)
0.0	0.0	GO:0001306	age-dependent response to oxidative stress(GO:0001306) age-dependent general metabolic decline(GO:0007571)
0.0	0.1	GO:0015889	cobalamin transport(GO:0015889)
0.0	0.3	GO:0018149	peptide cross-linking(GO:0018149)
0.0	0.0	GO:0071379	cellular response to prostaglandin stimulus(GO:0071379)
0.0	0.1	GO:0048625	myoblast fate commitment(GO:0048625)
0.0	0.1	GO:0090162	establishment of epithelial cell polarity(GO:0090162)
0.0	0.0	GO:0090382	phagolysosome assembly(GO:0001845) phagosome maturation(GO:0090382)
0.0	0.1	GO:0007603	phototransduction, visible light(GO:0007603)
0.0	0.1	GO:0045880	positive regulation of smoothened signaling pathway(GO:0045880)
0.0	0.0	GO:0031558	obsolete induction of apoptosis in response to chemical stimulus(GO:0031558)
0.0	0.0	GO:0009169	nucleoside monophosphate catabolic process(GO:0009125) purine nucleoside monophosphate catabolic process(GO:0009128) ribonucleoside monophosphate catabolic process(GO:0009158) purine ribonucleoside monophosphate catabolic process(GO:0009169)
0.0	0.1	GO:0060644	mammary gland epithelial cell differentiation(GO:0060644)
0.0	0.1	GO:0070389	chaperone cofactor-dependent protein refolding(GO:0070389)
0.0	0.2	GO:0014075	response to amine(GO:0014075)
0.0	0.0	GO:0060997	dendritic spine morphogenesis(GO:0060997) regulation of dendritic spine morphogenesis(GO:0061001) dendritic spine organization(GO:0097061)
0.0	0.0	GO:0007352	zygotic specification of dorsal/ventral axis(GO:0007352)
0.0	0.0	GO:0003010	voluntary skeletal muscle contraction(GO:0003010) twitch skeletal muscle contraction(GO:0014721)
0.0	0.1	GO:0032055	negative regulation of translation in response to stress(GO:0032055)
0.0	0.0	GO:0003085	negative regulation of systemic arterial blood pressure(GO:0003085)
0.0	0.0	GO:0009299	mRNA transcription(GO:0009299)
0.0	0.0	GO:0040016	embryonic cleavage(GO:0040016)
0.0	0.2	GO:0045103	intermediate filament-based process(GO:0045103)
0.0	0.0	GO:0030309	poly-N-acetyllactosamine metabolic process(GO:0030309)
0.0	0.0	GO:0014912	negative regulation of smooth muscle cell migration(GO:0014912)
0.0	0.0	GO:0071318	cellular response to ATP(GO:0071318)
0.0	0.0	GO:0015870	acetylcholine transport(GO:0015870) acetate ester transport(GO:1901374)
0.0	0.0	GO:0070141	response to UV-A(GO:0070141)
0.0	0.0	GO:0021910	smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021910)
0.0	0.1	GO:0043922	negative regulation by host of viral transcription(GO:0043922)
0.0	0.1	GO:0048853	forebrain morphogenesis(GO:0048853)
0.0	0.0	GO:0040037	negative regulation of fibroblast growth factor receptor signaling pathway(GO:0040037)
0.0	0.0	GO:0009219	pyrimidine deoxyribonucleotide metabolic process(GO:0009219)
0.0	0.3	GO:0060606	neural tube closure(GO:0001843) tube closure(GO:0060606)
0.0	0.3	GO:0036503	ER-associated ubiquitin-dependent protein catabolic process(GO:0030433) ERAD pathway(GO:0036503)
0.0	0.1	GO:0050872	white fat cell differentiation(GO:0050872)
0.0	0.1	GO:0046839	phospholipid dephosphorylation(GO:0046839)
0.0	0.1	GO:0035329	hippo signaling(GO:0035329)
0.0	0.1	GO:0018200	peptidyl-glutamic acid modification(GO:0018200)
0.0	0.0	GO:0055089	fatty acid homeostasis(GO:0055089)
0.0	0.0	GO:0002495	antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.0	0.0	GO:0051877	pigment granule aggregation in cell center(GO:0051877)
0.0	0.0	GO:0072070	loop of Henle development(GO:0072070)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.1	GO:0071664	catenin-TCF7L2 complex(GO:0071664)
0.0	0.1	GO:0042622	photoreceptor outer segment membrane(GO:0042622)
0.0	0.1	GO:0001940	male pronucleus(GO:0001940)
0.0	0.1	GO:0032059	bleb(GO:0032059)
0.0	0.1	GO:0000138	Golgi trans cisterna(GO:0000138)
0.0	0.1	GO:0030056	hemidesmosome(GO:0030056)
0.0	0.1	GO:0042825	TAP complex(GO:0042825)
0.0	0.1	GO:0043625	delta DNA polymerase complex(GO:0043625)
0.0	0.1	GO:0000176	nuclear exosome (RNase complex)(GO:0000176)
0.0	0.1	GO:0030061	mitochondrial crista(GO:0030061)
0.0	0.2	GO:0098642	network-forming collagen trimer(GO:0098642) collagen network(GO:0098645)
0.0	0.1	GO:0031092	platelet alpha granule membrane(GO:0031092)
0.0	0.1	GO:0016342	catenin complex(GO:0016342)
0.0	0.1	GO:0033179	proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.0	0.1	GO:0045254	pyruvate dehydrogenase complex(GO:0045254)
0.0	0.1	GO:0005614	interstitial matrix(GO:0005614)
0.0	0.2	GO:0016281	eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0	0.1	GO:0036126	outer dense fiber(GO:0001520) sperm flagellum(GO:0036126)
0.0	0.1	GO:0042587	glycogen granule(GO:0042587)
0.0	0.1	GO:0070044	synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
0.0	0.1	GO:0044298	neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0	0.1	GO:0016327	apicolateral plasma membrane(GO:0016327)
0.0	0.1	GO:0031094	platelet dense tubular network(GO:0031094)
0.0	0.1	GO:0001917	photoreceptor inner segment(GO:0001917)
0.0	0.1	GO:0005721	pericentric heterochromatin(GO:0005721)
0.0	0.1	GO:0005766	primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.0	0.0	GO:0071986	Ragulator complex(GO:0071986)
0.0	0.1	GO:0005915	zonula adherens(GO:0005915)
0.0	0.2	GO:0005811	lipid particle(GO:0005811)
0.0	0.1	GO:0031430	M band(GO:0031430)
0.0	0.1	GO:0005861	troponin complex(GO:0005861)
0.0	0.0	GO:0009331	glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.0	0.0	GO:0008537	proteasome activator complex(GO:0008537)
0.0	0.0	GO:0060201	clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201)
0.0	0.0	GO:0005588	collagen type V trimer(GO:0005588)
0.0	0.0	GO:0098647	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0	0.1	GO:0031143	pseudopodium(GO:0031143)
0.0	0.1	GO:0005663	DNA replication factor C complex(GO:0005663)
0.0	0.0	GO:0005853	eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0	0.1	GO:0032039	integrator complex(GO:0032039)
0.0	0.1	GO:0019773	proteasome core complex, alpha-subunit complex(GO:0019773)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0004157	dihydropyrimidinase activity(GO:0004157)
0.1	0.2	GO:0005173	stem cell factor receptor binding(GO:0005173)
0.1	0.2	GO:0005010	insulin-like growth factor-activated receptor activity(GO:0005010)
0.1	0.2	GO:0000293	ferric-chelate reductase activity(GO:0000293)
0.0	0.1	GO:0045236	CXCR chemokine receptor binding(GO:0045236)
0.0	0.2	GO:0070215	obsolete MDM2 binding(GO:0070215)
0.0	0.1	GO:0004937	alpha1-adrenergic receptor activity(GO:0004937)
0.0	0.3	GO:0004908	interleukin-1 receptor activity(GO:0004908)
0.0	0.1	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0	0.2	GO:0030297	transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.0	0.1	GO:0048027	mRNA 5'-UTR binding(GO:0048027)
0.0	0.1	GO:0046980	tapasin binding(GO:0046980)
0.0	0.1	GO:0019166	trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166)
0.0	0.2	GO:0017154	semaphorin receptor activity(GO:0017154)
0.0	0.2	GO:0048406	nerve growth factor binding(GO:0048406)
0.0	0.1	GO:0004470	malic enzyme activity(GO:0004470)
0.0	0.1	GO:0015065	uridine nucleotide receptor activity(GO:0015065) G-protein coupled pyrimidinergic nucleotide receptor activity(GO:0071553)
0.0	0.1	GO:0017162	aryl hydrocarbon receptor binding(GO:0017162)
0.0	0.2	GO:0005497	androgen binding(GO:0005497)
0.0	0.1	GO:0004117	calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117)
0.0	0.3	GO:0004312	fatty acid synthase activity(GO:0004312)
0.0	0.2	GO:0042153	obsolete RPTP-like protein binding(GO:0042153)
0.0	0.1	GO:0031994	insulin-like growth factor I binding(GO:0031994)
0.0	0.1	GO:0052650	NADP-retinol dehydrogenase activity(GO:0052650)
0.0	0.1	GO:0005152	interleukin-1 receptor antagonist activity(GO:0005152)
0.0	0.2	GO:0003810	protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0	0.1	GO:0047756	chondroitin 4-sulfotransferase activity(GO:0047756)
0.0	0.1	GO:0004095	carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.0	0.1	GO:0033130	acetylcholine receptor binding(GO:0033130)
0.0	0.1	GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.0	0.1	GO:0016151	nickel cation binding(GO:0016151)
0.0	0.1	GO:0001515	opioid peptide activity(GO:0001515)
0.0	0.2	GO:0043560	insulin receptor substrate binding(GO:0043560)
0.0	0.1	GO:0015204	urea transmembrane transporter activity(GO:0015204)
0.0	0.3	GO:0005161	platelet-derived growth factor receptor binding(GO:0005161)
0.0	0.1	GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.0	0.1	GO:0008046	axon guidance receptor activity(GO:0008046)
0.0	0.1	GO:0005294	neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.0	0.2	GO:0004017	adenylate kinase activity(GO:0004017)
0.0	0.1	GO:0019855	calcium channel inhibitor activity(GO:0019855)
0.0	0.2	GO:0016813	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.0	0.1	GO:0015016	[heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0	0.1	GO:0016413	O-acetyltransferase activity(GO:0016413)
0.0	0.1	GO:0070643	vitamin D3 25-hydroxylase activity(GO:0030343) vitamin D 25-hydroxylase activity(GO:0070643)
0.0	0.1	GO:0005042	netrin receptor activity(GO:0005042)
0.0	0.1	GO:0015194	L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.0	0.1	GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0	0.1	GO:0045499	chemorepellent activity(GO:0045499)
0.0	0.1	GO:0005534	galactose binding(GO:0005534)
0.0	0.1	GO:0030172	troponin C binding(GO:0030172)
0.0	0.1	GO:0004322	ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0	0.1	GO:0004969	histamine receptor activity(GO:0004969)
0.0	0.1	GO:0005384	manganese ion transmembrane transporter activity(GO:0005384)
0.0	0.1	GO:0045569	TRAIL binding(GO:0045569)
0.0	0.1	GO:0034186	apolipoprotein A-I binding(GO:0034186)
0.0	0.1	GO:0051864	histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0	0.1	GO:0035514	DNA demethylase activity(GO:0035514) DNA-N1-methyladenine dioxygenase activity(GO:0043734)
0.0	0.1	GO:0032139	dinucleotide insertion or deletion binding(GO:0032139)
0.0	0.1	GO:0016909	JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0	0.1	GO:0016802	adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0	0.1	GO:0015467	G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0	0.1	GO:0050253	retinyl-palmitate esterase activity(GO:0050253)
0.0	0.1	GO:0004982	N-formyl peptide receptor activity(GO:0004982)
0.0	0.1	GO:0004814	arginine-tRNA ligase activity(GO:0004814)
0.0	0.2	GO:0016500	protein-hormone receptor activity(GO:0016500)
0.0	0.1	GO:0047372	acylglycerol lipase activity(GO:0047372)
0.0	0.1	GO:0046790	virion binding(GO:0046790)
0.0	0.1	GO:0015252	hydrogen ion channel activity(GO:0015252)
0.0	0.1	GO:0000036	ACP phosphopantetheine attachment site binding involved in fatty acid biosynthetic process(GO:0000036) ACP phosphopantetheine attachment site binding(GO:0044620) prosthetic group binding(GO:0051192)
0.0	0.0	GO:0015038	glutathione disulfide oxidoreductase activity(GO:0015038)
0.0	0.1	GO:0008253	5'-nucleotidase activity(GO:0008253)
0.0	0.1	GO:0008157	protein phosphatase 1 binding(GO:0008157)
0.0	0.0	GO:0017128	phospholipid scramblase activity(GO:0017128)
0.0	0.0	GO:0050682	AF-2 domain binding(GO:0050682)
0.0	0.1	GO:0008113	peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.0	0.0	GO:0004607	phosphatidylcholine-sterol O-acyltransferase activity(GO:0004607)
0.0	0.1	GO:0017112	Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0	0.1	GO:0070696	transmembrane receptor protein serine/threonine kinase binding(GO:0070696)
0.0	0.1	GO:0008020	G-protein coupled photoreceptor activity(GO:0008020)
0.0	0.0	GO:0004813	alanine-tRNA ligase activity(GO:0004813)
0.0	0.0	GO:0051371	muscle alpha-actinin binding(GO:0051371)
0.0	0.1	GO:0005087	Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.0	0.0	GO:0047623	AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0	0.1	GO:0008503	benzodiazepine receptor activity(GO:0008503)
0.0	0.1	GO:0005000	vasopressin receptor activity(GO:0005000)
0.0	0.1	GO:0005523	tropomyosin binding(GO:0005523)
0.0	0.1	GO:0008191	metalloendopeptidase inhibitor activity(GO:0008191)
0.0	0.0	GO:0008184	glycogen phosphorylase activity(GO:0008184)
0.0	0.1	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0	0.0	GO:0004738	pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.0	0.1	GO:0051428	peptide hormone receptor binding(GO:0051428)
0.0	0.1	GO:0030506	ankyrin binding(GO:0030506)
0.0	0.0	GO:0003680	AT DNA binding(GO:0003680)
0.0	0.0	GO:0001849	complement component C1q binding(GO:0001849)
0.0	0.0	GO:0004461	lactose synthase activity(GO:0004461)
0.0	0.0	GO:0015421	oligopeptide-transporting ATPase activity(GO:0015421)
0.0	0.1	GO:0003886	DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0	0.1	GO:0015057	thrombin receptor activity(GO:0015057)
0.0	0.1	GO:0005154	epidermal growth factor receptor binding(GO:0005154)
0.0	0.0	GO:0046848	hydroxyapatite binding(GO:0046848)
0.0	0.0	GO:0016509	long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0016509)
0.0	0.0	GO:0016454	serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0	0.0	GO:0008900	hydrogen:potassium-exchanging ATPase activity(GO:0008900)
0.0	0.1	GO:0004596	peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0	0.0	GO:0043398	HLH domain binding(GO:0043398)
0.0	0.1	GO:0051787	misfolded protein binding(GO:0051787)
0.0	0.0	GO:0005148	prolactin receptor binding(GO:0005148)
0.0	0.1	GO:0015250	water channel activity(GO:0015250)
0.0	0.0	GO:0004367	glycerol-3-phosphate dehydrogenase [NAD+] activity(GO:0004367)
0.0	0.2	GO:0004653	polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0	0.1	GO:0004523	RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.0	0.1	GO:0015643	toxic substance binding(GO:0015643)
0.0	0.0	GO:0008486	diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486)
0.0	0.1	GO:0015520	tetracycline:proton antiporter activity(GO:0015520)
0.0	0.0	GO:0019215	intermediate filament binding(GO:0019215)
0.0	0.1	GO:0005110	frizzled-2 binding(GO:0005110)
0.0	0.1	GO:0005521	lamin binding(GO:0005521)
0.0	0.0	GO:0010314	phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0	0.1	GO:0015220	choline transmembrane transporter activity(GO:0015220)
0.0	0.3	GO:0030145	manganese ion binding(GO:0030145)
0.0	0.0	GO:0016647	oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.0	0.0	GO:0050897	cobalt ion binding(GO:0050897)
0.0	0.1	GO:0005385	zinc ion transmembrane transporter activity(GO:0005385)
0.0	0.1	GO:0016595	glutamate binding(GO:0016595)
0.0	0.0	GO:0055077	gap junction hemi-channel activity(GO:0055077)
0.0	0.1	GO:0008649	rRNA methyltransferase activity(GO:0008649)
0.0	0.1	GO:0030169	low-density lipoprotein particle binding(GO:0030169)
0.0	0.1	GO:0070290	N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0	0.0	GO:0033765	steroid dehydrogenase activity, acting on the CH-CH group of donors(GO:0033765)
0.0	0.1	GO:0016713	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen(GO:0016713)
0.0	0.0	GO:0042289	MHC class II protein binding(GO:0042289)
0.0	0.0	GO:0034711	inhibin binding(GO:0034711)
0.0	0.0	GO:0004594	pantothenate kinase activity(GO:0004594)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.1	PID ECADHERIN KERATINOCYTE PATHWAY	E-cadherin signaling in keratinocytes
0.0	PID LPA4 PATHWAY	LPA4-mediated signaling events
0.1	PID ANGIOPOIETIN RECEPTOR PATHWAY	Angiopoietin receptor Tie2-mediated signaling
0.0	ST GA12 PATHWAY	G alpha 12 Pathway
0.1	ST INTEGRIN SIGNALING PATHWAY	Integrin Signaling Pathway
0.1	PID NETRIN PATHWAY	Netrin-mediated signaling events
0.4	PID SYNDECAN 2 PATHWAY	Syndecan-2-mediated signaling events
0.0	ST PAC1 RECEPTOR PATHWAY	PAC1 Receptor Pathway
0.5	PID UPA UPAR PATHWAY	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.3	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
0.3	PID S1P S1P2 PATHWAY	S1P2 pathway
0.4	PID INTEGRIN3 PATHWAY	Beta3 integrin cell surface interactions
0.0	PID PI3KCI AKT PATHWAY	Class I PI3K signaling events mediated by Akt
0.1	PID AR NONGENOMIC PATHWAY	Nongenotropic Androgen signaling
0.2	SA B CELL RECEPTOR COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.2	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.1	REACTOME DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR	Genes involved in Downstream Signaling Events Of B Cell Receptor (BCR)
0.0	0.3	REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	Genes involved in DCC mediated attractive signaling
0.0	0.1	REACTOME PLATELET AGGREGATION PLUG FORMATION	Genes involved in Platelet Aggregation (Plug Formation)
0.0	0.5	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0	0.2	REACTOME CRMPS IN SEMA3A SIGNALING	Genes involved in CRMPs in Sema3A signaling
0.0	0.0	REACTOME ARMS MEDIATED ACTIVATION	Genes involved in ARMS-mediated activation
0.0	0.0	REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE	Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0	0.3	REACTOME OTHER SEMAPHORIN INTERACTIONS	Genes involved in Other semaphorin interactions
0.0	0.0	REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1	Genes involved in Signaling by activated point mutants of FGFR1
0.0	0.1	REACTOME ROLE OF DCC IN REGULATING APOPTOSIS	Genes involved in Role of DCC in regulating apoptosis
0.0	0.2	REACTOME PURINE CATABOLISM	Genes involved in Purine catabolism
0.0	0.2	REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE	Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0	0.0	REACTOME PLC BETA MEDIATED EVENTS	Genes involved in PLC beta mediated events
0.0	0.0	REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL	Genes involved in NF-kB is activated and signals survival
0.0	0.3	REACTOME BASIGIN INTERACTIONS	Genes involved in Basigin interactions
0.0	0.2	REACTOME POL SWITCHING	Genes involved in Polymerase switching
0.0	0.2	REACTOME GLYCOPROTEIN HORMONES	Genes involved in Glycoprotein hormones
0.0	0.2	REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS	Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0	0.1	REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP	Genes involved in Destabilization of mRNA by Tristetraprolin (TTP)
0.0	0.3	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.0	0.2	REACTOME ENDOGENOUS STEROLS	Genes involved in Endogenous sterols
0.0	0.1	REACTOME PASSIVE TRANSPORT BY AQUAPORINS	Genes involved in Passive Transport by Aquaporins
0.0	0.0	REACTOME NEF MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS	Genes involved in Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
0.0	0.2	REACTOME SIGNALING BY HIPPO	Genes involved in Signaling by Hippo
0.0	0.0	REACTOME BOTULINUM NEUROTOXICITY	Genes involved in Botulinum neurotoxicity
0.0	0.0	REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Dopamine Neurotransmitter Release Cycle
0.0	0.2	REACTOME GRB2 EVENTS IN ERBB2 SIGNALING	Genes involved in GRB2 events in ERBB2 signaling
0.0	0.1	REACTOME MTORC1 MEDIATED SIGNALLING	Genes involved in mTORC1-mediated signalling
0.0	0.1	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.0	0.0	REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS	Genes involved in CREB phosphorylation through the activation of Ras
0.0	0.1	REACTOME G PROTEIN ACTIVATION	Genes involved in G-protein activation
0.0	0.2	REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS	Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0	0.1	REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS	Genes involved in Activation of the AP-1 family of transcription factors
0.0	0.2	REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE	Genes involved in Synthesis of PIPs at the Golgi membrane
0.0	0.1	REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.0	0.0	REACTOME RETROGRADE NEUROTROPHIN SIGNALLING	Genes involved in Retrograde neurotrophin signalling
0.0	0.2	REACTOME PRE NOTCH PROCESSING IN GOLGI	Genes involved in Pre-NOTCH Processing in Golgi
0.0	0.0	REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION	Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0	0.1	REACTOME ERKS ARE INACTIVATED	Genes involved in ERKs are inactivated
0.0	0.2	REACTOME ACYL CHAIN REMODELLING OF PC	Genes involved in Acyl chain remodelling of PC
0.0	0.1	REACTOME DSCAM INTERACTIONS	Genes involved in DSCAM interactions