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ENCODE: H3K4me1 ChIP-Seq of primary human cells
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Results for NKX2-1

Z-value: 1.29

Motif logo

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Transcription factors associated with NKX2-1

Gene Symbol Gene ID Gene Info
NKX2-1
ENSG00000136352.13 NK2 homeobox 1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr14_36990374_36990607NKX2-11360.9432120.646.5e-02Click!
chr14_36989210_36989422NKX2-1230.9430310.481.9e-01Click!
chr14_36990794_36990945NKX2-15150.7241640.472.1e-01Click!
chr14_36989834_36989985NKX2-12450.8774290.284.6e-01Click!
chr14_36988822_36989041NKX2-1330.881591-0.137.4e-01Click!

Activity of the NKX2-1 motif across conditions

Conditions sorted by the z-value of the NKX2-1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr3_71591322_71591805 0.39 ENSG00000221264
 .
 323
 0.83
chr20_19739352_19739650 0.35 AL121761.2
 Uncharacterized protein
 822
 0.67
chr14_78668483_78668908 0.34 ENSG00000199454
 .
 24431
 0.22
chr9_114554047_114554198 0.33 C9orf84
 chromosome 9 open reading frame 84
 3090
 0.29
chr7_20254919_20255070 0.32 MACC1
 metastasis associated in colon cancer 1
 2019
 0.4
chr17_45334887_45335241 0.31 ENSG00000238419
 .
 1722
 0.26
chr15_99344237_99344527 0.31 ENSG00000264480
 .
 16727
 0.24
chr6_35393359_35394053 0.31 FANCE
 Fanconi anemia, complementation group E
 26432
 0.15
chr11_92441050_92441201 0.30 ENSG00000239086
 .
 21456
 0.24
chr18_24155354_24155632 0.29 ENSG00000252846
 .
 11269
 0.22
chr4_157888355_157888628 0.29 PDGFC
 platelet derived growth factor C
 3564
 0.27
chr8_23397789_23397996 0.29 SLC25A37
 solute carrier family 25 (mitochondrial iron transporter), member 37
 11319
 0.16
chr20_1460805_1460958 0.28 ENSG00000266085
 .
 8314
 0.14
chr7_72974638_72974971 0.28 BCL7B
 B-cell CLL/lymphoma 7B
 2472
 0.22
chr2_65087186_65087345 0.28 ENSG00000199964
 .
 25974
 0.15
chr1_86038271_86038452 0.28 DDAH1
 dimethylarginine dimethylaminohydrolase 1
 5572
 0.2
chr11_9778479_9778630 0.27 SBF2-AS1
 SBF2 antisense RNA 1
 1285
 0.44
chr17_42425530_42425884 0.27 GRN
 granulin
 2200
 0.16
chr7_152010807_152011572 0.27 KMT2C
 lysine (K)-specific methyltransferase 2C
 66085
 0.11
chr9_33354750_33355149 0.26 ENSG00000200544
 .
 2077
 0.27
chr11_75735939_75736309 0.26 UVRAG
 UV radiation resistance associated
 41644
 0.15
chr17_438204_438582 0.26 RP5-1029F21.4
12013
 0.17
chr17_40562098_40562486 0.26 ENSG00000221020
 .
 11265
 0.11
chr7_134938605_134938973 0.26 STRA8
 stimulated by retinoic acid 8
 22058
 0.17
chr12_54655635_54656068 0.26 RP11-968A15.2
548
 0.55
chr21_40683413_40684326 0.26 BRWD1
 bromodomain and WD repeat domain containing 1
 1627
 0.24
chr2_69309476_69309763 0.26 ANTXR1
 anthrax toxin receptor 1
 6884
 0.22
chr1_109931574_109931829 0.26 SORT1
 sortilin 1
 4278
 0.19
chr5_149189745_149189896 0.25 PPARGC1B
 peroxisome proliferator-activated receptor gamma, coactivator 1 beta
 22758
 0.18
chr1_9145986_9146241 0.25 SLC2A5
 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
 2389
 0.23
chr5_126898357_126898508 0.25 PRRC1
 proline-rich coiled-coil 1
 45084
 0.18
chr11_74347920_74348157 0.25 POLD3
 polymerase (DNA-directed), delta 3, accessory subunit
 1621
 0.37
chr5_72511846_72512133 0.25 TMEM174
 transmembrane protein 174
 42967
 0.14
chr6_147234985_147235152 0.25 STXBP5-AS1
 STXBP5 antisense RNA 1
 1953
 0.49
chr8_26123678_26123924 0.24 PPP2R2A
 protein phosphatase 2, regulatory subunit B, alpha
 25206
 0.23
chr17_42872109_42872587 0.24 GJC1
 gap junction protein, gamma 1, 45kDa
 9986
 0.14
chr1_235104740_235105149 0.24 ENSG00000239690
 .
 65011
 0.12
chr2_219597745_219597964 0.24 TTLL4
 tubulin tyrosine ligase-like family, member 4
 4443
 0.16
chr1_10958313_10958477 0.24 C1orf127
 chromosome 1 open reading frame 127
 49532
 0.12
chr15_92034111_92034262 0.24 SV2B
 synaptic vesicle glycoprotein 2B
 265086
 0.02
chr5_171530999_171531150 0.24 ENSG00000266671
 .
 23094
 0.19
chr1_95119284_95119435 0.24 ENSG00000263526
 .
 92097
 0.08
chr10_81109102_81109275 0.24 PPIF
 peptidylprolyl isomerase F
 1774
 0.38
chr22_19074070_19074357 0.24 AC004471.9
34829
 0.09
chr2_38404404_38404678 0.24 ENSG00000199603
 .
 29984
 0.19
chr5_138753028_138753179 0.23 DNAJC18
 DnaJ (Hsp40) homolog, subfamily C, member 18
 7634
 0.1
chr19_1796326_1796477 0.23 ATP8B3
 ATPase, aminophospholipid transporter, class I, type 8B, member 3
 15222
 0.09
chr11_34443753_34443957 0.23 CAT
 catalase
 16617
 0.22
chr12_32655690_32655927 0.23 FGD4
 FYVE, RhoGEF and PH domain containing 4
 657
 0.77
chr17_54236463_54236752 0.23 ANKFN1
 ankyrin-repeat and fibronectin type III domain containing 1
 5736
 0.33
chr1_29575738_29576111 0.23 ENSG00000221550
 .
 4271
 0.18
chr1_28879167_28879368 0.23 TRNAU1AP
 tRNA selenocysteine 1 associated protein 1
 330
 0.8
chr4_140099443_140099664 0.23 ELF2
 E74-like factor 2 (ets domain transcription factor)
 1181
 0.4
chr17_71064314_71064465 0.23 SLC39A11
 solute carrier family 39, member 11
 21514
 0.23
chr16_81534432_81534869 0.23 CMIP
 c-Maf inducing protein
 5696
 0.3
chr1_49083295_49083518 0.23 AGBL4
 ATP/GTP binding protein-like 4
 63168
 0.14
chr3_171579285_171579488 0.23 TMEM212
 transmembrane protein 212
 18080
 0.18
chr6_142699159_142699742 0.23 GPR126
 G protein-coupled receptor 126
 11999
 0.29
chr12_64261703_64261854 0.23 RP11-274J7.2
10789
 0.17
chr6_37023589_37023822 0.22 COX6A1P2
 cytochrome c oxidase subunit VIa polypeptide 1 pseudogene 2
 11098
 0.2
chr1_235035137_235035288 0.22 ENSG00000239690
 .
 4721
 0.3
chr5_146889795_146890041 0.22 DPYSL3
 dihydropyrimidinase-like 3
 299
 0.94
chr8_130691624_130691889 0.22 GSDMC
 gasdermin C
 107378
 0.06
chr15_66910964_66911559 0.22 RP11-321F6.1
 HCG2003567; Uncharacterized protein
 36733
 0.12
chr20_11790867_11791018 0.22 ENSG00000222281
 .
 8797
 0.29
chr6_7130248_7130425 0.22 RREB1
 ras responsive element binding protein 1
 9142
 0.22
chr1_175560414_175560565 0.22 TNR-IT1
 TNR intronic transcript 1 (non-protein coding)
 34535
 0.23
chr10_54286609_54286760 0.22 RP11-556E13.1
34181
 0.24
chr6_109063657_109063820 0.22 FOXO3
 forkhead box O3
 86189
 0.09
chr1_61650059_61650312 0.21 RP4-802A10.1
59780
 0.14
chr7_93868977_93869198 0.21 COL1A2
 collagen, type I, alpha 2
 154786
 0.04
chr4_120024366_120024563 0.21 MYOZ2
 myozenin 2
 32475
 0.19
chr5_133837543_133837821 0.21 ENSG00000207222
 .
 1707
 0.32
chr11_10350303_10350459 0.21 AMPD3
 adenosine monophosphate deaminase 3
 11163
 0.16
chr7_127858076_127858330 0.21 ENSG00000207705
 .
 10279
 0.19
chr1_165831561_165831763 0.21 UCK2
 uridine-cytidine kinase 2
 33145
 0.15
chr9_130302299_130302610 0.21 FAM129B
 family with sequence similarity 129, member B
 28913
 0.13
chr12_3226541_3226699 0.21 TSPAN9-IT1
 TSPAN9 intronic transcript 1 (non-protein coding)
 32343
 0.17
chr17_33568770_33569141 0.21 RP11-799D4.4
1027
 0.35
chr2_153277819_153278036 0.20 FMNL2
 formin-like 2
 86176
 0.1
chr2_47262098_47262362 0.20 AC093732.1
5433
 0.21
chr1_208381209_208381624 0.20 PLXNA2
 plexin A2
 36249
 0.24
chr13_40684091_40684242 0.20 ENSG00000207458
 .
 116798
 0.07
chr3_172036187_172036338 0.20 AC092964.1
 Uncharacterized protein
 2044
 0.36
chr1_95296795_95296987 0.20 SLC44A3
 solute carrier family 44, member 3
 10685
 0.21
chr18_9704973_9705544 0.20 RAB31
 RAB31, member RAS oncogene family
 2904
 0.31
chr9_111826033_111826184 0.20 ENSG00000207698
 .
 17530
 0.14
chr2_43191638_43192077 0.20 ENSG00000207087
 .
 126775
 0.05
chr12_49626134_49626329 0.20 TUBA1C
 tubulin, alpha 1c
 4522
 0.14
chr16_85244563_85244846 0.20 CTC-786C10.1
39822
 0.17
chr8_57595398_57595566 0.20 RP11-17A4.2
193825
 0.03
chr17_38171762_38172321 0.20 CSF3
 colony stimulating factor 3 (granulocyte)
 301
 0.83
chr14_89824555_89824893 0.20 RP11-356K23.2
3320
 0.22
chr1_157373506_157373754 0.20 FCRL5
 Fc receptor-like 5
 148550
 0.04
chr7_42277787_42277938 0.20 GLI3
 GLI family zinc finger 3
 1204
 0.66
chr3_134317870_134318272 0.20 EPHB1
 EPH receptor B1
 16136
 0.21
chr17_1548050_1548254 0.20 SCARF1
 scavenger receptor class F, member 1
 886
 0.4
chr5_139727515_139728049 0.19 HBEGF
 heparin-binding EGF-like growth factor
 1566
 0.26
chr13_107137363_107137514 0.19 EFNB2
 ephrin-B2
 50024
 0.17
chr3_185479152_185479525 0.19 ENSG00000265470
 .
 6354
 0.24
chr17_43253672_43253834 0.19 RP13-890H12.2
4802
 0.11
chr9_119714349_119714500 0.19 ENSG00000265662
 .
 146862
 0.04
chr15_99226253_99226598 0.19 IGF1R
 insulin-like growth factor 1 receptor
 24635
 0.2
chr7_16697056_16697503 0.19 BZW2
 basic leucine zipper and W2 domains 2
 3569
 0.24
chr14_21574185_21574440 0.19 ZNF219
 zinc finger protein 219
 1431
 0.25
chr1_178911938_178912211 0.19 RALGPS2
 Ral GEF with PH domain and SH3 binding motif 2
 56860
 0.12
chr5_124201652_124202095 0.19 ZNF608
 zinc finger protein 608
 117373
 0.06
chr2_153324557_153324708 0.19 FMNL2
 formin-like 2
 132881
 0.05
chr5_14154020_14154339 0.19 TRIO
 trio Rho guanine nucleotide exchange factor
 10350
 0.32
chr1_77748942_77749155 0.19 AK5
 adenylate kinase 5
 284
 0.93
chr7_2680395_2680583 0.19 TTYH3
 tweety family member 3
 4677
 0.21
chr2_70699360_70699623 0.19 TGFA-IT1
 TGFA intronic transcript 1 (non-protein coding)
 3864
 0.2
chr20_44538606_44538964 0.19 PLTP
 phospholipid transfer protein
 791
 0.42
chr2_172380569_172381265 0.19 CYBRD1
 cytochrome b reductase 1
 1328
 0.53
chr11_88256352_88256580 0.19 GRM5-AS1
 GRM5 antisense RNA 1
 11550
 0.29
chr6_64516560_64517136 0.19 RP11-59D5__B.2
119
 0.98
chr12_22436696_22436847 0.19 ST8SIA1
 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
 34791
 0.21
chr6_137587453_137587604 0.19 IFNGR1
 interferon gamma receptor 1
 46942
 0.17
chr10_33653913_33654108 0.18 NRP1
 neuropilin 1
 28820
 0.23
chr1_242494290_242494441 0.18 PLD5
 phospholipase D family, member 5
 118362
 0.06
chr15_75418307_75418680 0.18 ENSG00000252722
 .
 4486
 0.2
chr2_87016233_87016699 0.18 CD8A
 CD8a molecule
 1482
 0.41
chr2_14775111_14775564 0.18 AC011897.1
 Uncharacterized protein
 122
 0.97
chr18_10594479_10594630 0.18 RP11-856M7.1
67376
 0.1
chr2_235933793_235934065 0.18 SH3BP4
 SH3-domain binding protein 4
 30445
 0.26
chr4_143883337_143883532 0.18 INPP4B
 inositol polyphosphate-4-phosphatase, type II, 105kDa
 114849
 0.07
chr8_126510706_126510857 0.18 ENSG00000266452
 .
 53974
 0.15
chr21_39875635_39875873 0.18 ERG
 v-ets avian erythroblastosis virus E26 oncogene homolog
 5347
 0.34
chr9_93959973_93960173 0.18 AUH
 AU RNA binding protein/enoyl-CoA hydratase
 164104
 0.04
chr4_40623166_40623743 0.18 RBM47
 RNA binding motif protein 47
 8427
 0.27
chr1_31350251_31350496 0.18 SDC3
 syndecan 3
 1214
 0.42
chr2_20311558_20311709 0.18 RP11-644K8.1
59738
 0.09
chr6_106329312_106329592 0.18 ENSG00000200198
 .
 22796
 0.27
chr12_1702754_1702905 0.18 FBXL14
 F-box and leucine-rich repeat protein 14
 502
 0.82
chr8_29420044_29420195 0.18 RP4-676L2.1
209432
 0.02
chr1_49243286_49243470 0.18 BEND5
 BEN domain containing 5
 788
 0.77
chr7_23503511_23503662 0.18 IGF2BP3
 insulin-like growth factor 2 mRNA binding protein 3
 6500
 0.18
chr7_100781001_100781597 0.18 SERPINE1
 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
 10920
 0.1
chr8_29492885_29493176 0.18 RP4-676L2.1
282343
 0.01
chr20_17972943_17973101 0.18 MGME1
 mitochondrial genome maintenance exonuclease 1
 23264
 0.13
chr7_41727697_41728013 0.18 INHBA-AS1
 INHBA antisense RNA 1
 5659
 0.22
chr2_197853357_197853508 0.18 ANKRD44
 ankyrin repeat domain 44
 11794
 0.26
chr12_50447359_50447620 0.18 ASIC1
 acid-sensing (proton-gated) ion channel 1
 3842
 0.15
chr2_204513967_204514120 0.17 CD28
 CD28 molecule
 57155
 0.14
chr1_28653417_28653596 0.17 MED18
 mediator complex subunit 18
 2043
 0.28
chr7_99970452_99970794 0.17 PILRA
 paired immunoglobin-like type 2 receptor alpha
 445
 0.66
chr7_138664896_138665077 0.17 KIAA1549
 KIAA1549
 1078
 0.59
chr11_63388800_63389118 0.17 RP11-697H9.3
5179
 0.15
chr20_52355039_52355190 0.17 ENSG00000238468
 .
 69817
 0.12
chr19_41936846_41937128 0.17 B3GNT8
 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8
 2352
 0.14
chr6_47276047_47276198 0.17 TNFRSF21
 tumor necrosis factor receptor superfamily, member 21
 1519
 0.54
chr1_56991345_56991645 0.17 PPAP2B
 phosphatidic acid phosphatase type 2B
 53746
 0.16
chr1_61718931_61719082 0.17 NFIA
 nuclear factor I/A
 99116
 0.08
chr7_22899009_22899286 0.17 ENSG00000221740
 .
 2915
 0.31
chr22_41762881_41763188 0.17 TEF
 thyrotrophic embryonic factor
 303
 0.87
chr3_184355166_184355357 0.17 MAGEF1
 melanoma antigen family F, 1
 74575
 0.09
chr2_70368551_70369209 0.17 C2orf42
 chromosome 2 open reading frame 42
 40247
 0.11
chr16_74777388_74777539 0.17 FA2H
 fatty acid 2-hydroxylase
 2296
 0.28
chr21_40211048_40211199 0.17 ETS2
 v-ets avian erythroblastosis virus E26 oncogene homolog 2
 29563
 0.22
chr5_6705329_6705555 0.17 PAPD7
 PAP associated domain containing 7
 9276
 0.26
chr8_6372842_6373023 0.17 ANGPT2
 angiopoietin 2
 47633
 0.16
chr16_1742334_1742485 0.17 HN1L
 hematological and neurological expressed 1-like
 6908
 0.09
chr4_15452943_15453218 0.17 CC2D2A
 coiled-coil and C2 domain containing 2A
 18409
 0.16
chr6_56820926_56821126 0.17 BEND6
 BEN domain containing 6
 856
 0.52
chr5_37249784_37249952 0.17 C5orf42
 chromosome 5 open reading frame 42
 338
 0.89
chr7_134477490_134477641 0.17 CALD1
 caldesmon 1
 13136
 0.28
chr18_53156534_53156869 0.17 RP11-619L19.2
2705
 0.26
chr20_52556645_52557141 0.17 AC005220.3
194
 0.96
chr11_119563178_119563367 0.17 PVRL1
 poliovirus receptor-related 1 (herpesvirus entry mediator C)
 35991
 0.13
chr2_208734859_208735279 0.17 AC083900.1
430
 0.86
chr5_102294298_102294449 0.17 PAM
 peptidylglycine alpha-amidating monooxygenase
 9092
 0.31
chr1_46598395_46598546 0.17 PIK3R3
 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
 4
 0.96
chr3_185463874_185464186 0.17 ENSG00000265470
 .
 21662
 0.19
chr8_124642901_124643058 0.17 CTD-2552K11.2
16514
 0.17
chr3_25515158_25515309 0.17 RARB
 retinoic acid receptor, beta
 15432
 0.26
chr11_103553300_103553882 0.17 ENSG00000264200
 .
 167043
 0.04
chr6_37279555_37279706 0.17 RNF8
 ring finger protein 8, E3 ubiquitin protein ligase
 42118
 0.11
chr6_150209605_150209756 0.17 RAET1E-AS1
 RAET1E antisense RNA 1
 1559
 0.24
chr10_81104566_81104717 0.17 PPIF
 peptidylprolyl isomerase F
 2586
 0.3
chr10_116474114_116474265 0.17 ABLIM1
 actin binding LIM protein 1
 29775
 0.21
chr10_80328339_80328521 0.17 ENSG00000223243
 .
 181929
 0.03
chr7_115995833_115995984 0.17 ENSG00000216076
 .
 9910
 0.21
chr22_44704942_44705093 0.17 KIAA1644
 KIAA1644
 3714
 0.31
chrX_48858096_48858311 0.17 GRIPAP1
 GRIP1 associated protein 1
 442
 0.68
chr20_61334808_61334959 0.17 NTSR1
 neurotensin receptor 1 (high affinity)
 5306
 0.14
chr3_105089117_105089308 0.17 ALCAM
 activated leukocyte cell adhesion molecule
 3025
 0.42
chr8_23610347_23610498 0.17 ENSG00000216123
 .
 15736
 0.17
chr7_5674087_5674709 0.17 FSCN1
 fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)
 40081
 0.12
chr8_122176471_122176664 0.17 ENSG00000221644
 .
 22565
 0.27
chr9_96263559_96263710 0.17 FAM120A
 family with sequence similarity 120A
 30803
 0.14
chr16_74764278_74764475 0.17 FA2H
 fatty acid 2-hydroxylase
 10791
 0.18
chr4_140958813_140959347 0.16 RP11-392B6.1
90089
 0.09
chr10_21812025_21812176 0.16 SKIDA1
 SKI/DACH domain containing 1
 2511
 0.2
chr17_72747231_72747488 0.16 MIR3615
 microRNA 3615
 2308
 0.15
chr10_80850413_80850863 0.16 ZMIZ1
 zinc finger, MIZ-type containing 1
 21846
 0.22
chr16_66521179_66521358 0.16 AC132186.1
 CDNA FLJ27243 fis, clone SYN08134; Uncharacterized protein
 1521
 0.27
chr9_75080014_75080202 0.16 TMC1
 transmembrane channel-like 1
 56609
 0.14
chr6_123112103_123112308 0.16 SMPDL3A
 sphingomyelin phosphodiesterase, acid-like 3A
 1734
 0.38
chr1_33462562_33463087 0.16 RP1-117O3.2
10148
 0.14
chr16_12707264_12707435 0.16 CTD-3037G24.3
2448
 0.33

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX2-1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0060831 smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:0060831)
0.1 0.2 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.1 0.2 GO:0042663 endodermal cell fate specification(GO:0001714) regulation of endodermal cell fate specification(GO:0042663) regulation of endodermal cell differentiation(GO:1903224)
0.0 0.3 GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0 0.1 GO:0001996 positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996)
0.0 0.1 GO:0051573 negative regulation of histone H3-K9 methylation(GO:0051573)
0.0 0.1 GO:0071294 cellular response to zinc ion(GO:0071294)
0.0 0.1 GO:0045578 negative regulation of B cell differentiation(GO:0045578)
0.0 0.1 GO:0034625 fatty acid elongation, monounsaturated fatty acid(GO:0034625)
0.0 0.2 GO:0030321 transepithelial chloride transport(GO:0030321)
0.0 0.1 GO:0045425 positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process(GO:0045425)
0.0 0.0 GO:0060913 cardiac cell fate determination(GO:0060913)
0.0 0.1 GO:0051771 negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771)
0.0 0.1 GO:0032509 endosome transport via multivesicular body sorting pathway(GO:0032509)
0.0 0.2 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.0 0.1 GO:0072367 regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367)
0.0 0.0 GO:0051570 regulation of histone H3-K9 methylation(GO:0051570)
0.0 0.3 GO:0031274 pseudopodium assembly(GO:0031269) regulation of pseudopodium assembly(GO:0031272) positive regulation of pseudopodium assembly(GO:0031274)
0.0 0.1 GO:0003308 negative regulation of Wnt signaling pathway involved in heart development(GO:0003308)
0.0 0.0 GO:0031061 negative regulation of histone methylation(GO:0031061)
0.0 0.1 GO:0009448 gamma-aminobutyric acid metabolic process(GO:0009448)
0.0 0.1 GO:0009189 deoxyribonucleoside diphosphate biosynthetic process(GO:0009189)
0.0 0.0 GO:0060084 synaptic transmission involved in micturition(GO:0060084)
0.0 0.1 GO:0001992 regulation of systemic arterial blood pressure by vasopressin(GO:0001992)
0.0 0.1 GO:0072201 negative regulation of mesenchymal cell proliferation(GO:0072201)
0.0 0.0 GO:0070208 protein heterotrimerization(GO:0070208)
0.0 0.1 GO:0042271 susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.0 0.2 GO:0048755 branching morphogenesis of a nerve(GO:0048755)
0.0 0.2 GO:0001514 selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.0 0.1 GO:0048003 antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003)
0.0 0.1 GO:0070634 transepithelial ammonium transport(GO:0070634)
0.0 0.1 GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway(GO:0010803)
0.0 0.1 GO:0045715 negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715)
0.0 0.1 GO:0045091 regulation of single stranded viral RNA replication via double stranded DNA intermediate(GO:0045091)
0.0 0.1 GO:0042670 retinal cone cell differentiation(GO:0042670) retinal cone cell development(GO:0046549)
0.0 0.1 GO:0070295 renal water absorption(GO:0070295)
0.0 0.1 GO:0007028 cytoplasm organization(GO:0007028)
0.0 0.1 GO:0048702 embryonic neurocranium morphogenesis(GO:0048702)
0.0 0.1 GO:0060676 ureteric bud formation(GO:0060676)
0.0 0.1 GO:0033008 positive regulation of mast cell activation involved in immune response(GO:0033008) positive regulation of leukocyte degranulation(GO:0043302) positive regulation of mast cell degranulation(GO:0043306)
0.0 0.1 GO:0032497 detection of lipopolysaccharide(GO:0032497)
0.0 0.1 GO:0009405 pathogenesis(GO:0009405)
0.0 0.1 GO:0044803 multi-organism membrane organization(GO:0044803)
0.0 0.1 GO:0060251 regulation of glial cell proliferation(GO:0060251)
0.0 0.1 GO:0019985 translesion synthesis(GO:0019985)
0.0 0.1 GO:0070272 proton-transporting ATP synthase complex assembly(GO:0043461) proton-transporting ATP synthase complex biogenesis(GO:0070272)
0.0 0.0 GO:0001302 replicative cell aging(GO:0001302)
0.0 0.1 GO:0015840 urea transport(GO:0015840)
0.0 0.1 GO:0032959 inositol trisphosphate biosynthetic process(GO:0032959)
0.0 0.0 GO:0048807 female genitalia morphogenesis(GO:0048807)
0.0 0.0 GO:0032928 regulation of superoxide anion generation(GO:0032928)
0.0 0.1 GO:0051124 synaptic growth at neuromuscular junction(GO:0051124)
0.0 0.1 GO:0003321 positive regulation of blood pressure by epinephrine-norepinephrine(GO:0003321)
0.0 0.1 GO:0030538 embryonic genitalia morphogenesis(GO:0030538)
0.0 0.1 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.0 0.1 GO:0006562 proline catabolic process(GO:0006562)
0.0 0.2 GO:0030502 negative regulation of bone mineralization(GO:0030502)
0.0 0.1 GO:0060028 convergent extension involved in axis elongation(GO:0060028)
0.0 0.1 GO:0006663 platelet activating factor biosynthetic process(GO:0006663)
0.0 0.1 GO:0043276 anoikis(GO:0043276)
0.0 0.1 GO:0003161 cardiac conduction system development(GO:0003161)
0.0 0.1 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.0 0.1 GO:0015959 diadenosine polyphosphate metabolic process(GO:0015959)
0.0 0.1 GO:0045079 negative regulation of chemokine production(GO:0032682) negative regulation of chemokine biosynthetic process(GO:0045079)
0.0 0.0 GO:0010834 obsolete telomere maintenance via telomere shortening(GO:0010834)
0.0 0.1 GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.0 0.1 GO:0060907 positive regulation of macrophage cytokine production(GO:0060907)
0.0 0.1 GO:0071731 response to nitric oxide(GO:0071731)
0.0 0.0 GO:0070874 negative regulation of glycogen metabolic process(GO:0070874)
0.0 0.1 GO:0032328 alanine transport(GO:0032328)
0.0 0.0 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 0.1 GO:0035610 C-terminal protein deglutamylation(GO:0035609) protein side chain deglutamylation(GO:0035610)
0.0 0.0 GO:0051547 regulation of keratinocyte migration(GO:0051547) positive regulation of keratinocyte migration(GO:0051549)
0.0 0.2 GO:0035413 positive regulation of catenin import into nucleus(GO:0035413)
0.0 0.1 GO:0051873 disruption by host of symbiont cells(GO:0051852) killing by host of symbiont cells(GO:0051873)
0.0 0.1 GO:0006065 UDP-glucuronate biosynthetic process(GO:0006065)
0.0 0.1 GO:0060433 bronchus development(GO:0060433)
0.0 0.1 GO:0090084 negative regulation of inclusion body assembly(GO:0090084)
0.0 0.5 GO:0030574 collagen catabolic process(GO:0030574)
0.0 0.1 GO:0046618 drug export(GO:0046618)
0.0 0.1 GO:0005981 regulation of glycogen catabolic process(GO:0005981)
0.0 0.2 GO:0000052 citrulline metabolic process(GO:0000052)
0.0 0.1 GO:0009249 protein lipoylation(GO:0009249)
0.0 0.1 GO:0071425 hematopoietic stem cell proliferation(GO:0071425)
0.0 0.1 GO:0009414 response to water deprivation(GO:0009414)
0.0 0.1 GO:0021535 cell migration in hindbrain(GO:0021535)
0.0 0.1 GO:0010842 retina layer formation(GO:0010842)
0.0 0.1 GO:0006296 nucleotide-excision repair, DNA incision, 5'-to lesion(GO:0006296)
0.0 0.1 GO:0031641 regulation of myelination(GO:0031641)
0.0 0.0 GO:0032277 negative regulation of gonadotropin secretion(GO:0032277)
0.0 0.0 GO:0015691 cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
0.0 0.2 GO:0000731 DNA synthesis involved in DNA repair(GO:0000731)
0.0 0.2 GO:0009629 response to gravity(GO:0009629)
0.0 0.1 GO:0071157 negative regulation of cell cycle arrest(GO:0071157)
0.0 0.1 GO:0044320 cellular response to leptin stimulus(GO:0044320) response to leptin(GO:0044321)
0.0 0.0 GO:0032957 inositol trisphosphate metabolic process(GO:0032957)
0.0 0.1 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.0 0.1 GO:0060406 positive regulation of penile erection(GO:0060406)
0.0 0.1 GO:0045112 integrin biosynthetic process(GO:0045112)
0.0 0.1 GO:0061303 cornea development in camera-type eye(GO:0061303)
0.0 0.1 GO:0008215 spermine metabolic process(GO:0008215)
0.0 0.1 GO:1900115 sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.0 0.1 GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.0 0.2 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.0 0.1 GO:0090267 positive regulation of spindle checkpoint(GO:0090232) regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267) positive regulation of cell cycle checkpoint(GO:1901978) regulation of mitotic spindle checkpoint(GO:1903504)
0.0 0.1 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.0 0.1 GO:0060259 regulation of feeding behavior(GO:0060259)
0.0 0.1 GO:0035511 oxidative DNA demethylation(GO:0035511)
0.0 0.1 GO:0072385 minus-end-directed organelle transport along microtubule(GO:0072385)
0.0 0.0 GO:0061081 positive regulation of myeloid leukocyte cytokine production involved in immune response(GO:0061081)
0.0 0.1 GO:0050703 interleukin-1 alpha secretion(GO:0050703)
0.0 0.1 GO:0061088 regulation of sequestering of zinc ion(GO:0061088)
0.0 0.1 GO:0007216 G-protein coupled glutamate receptor signaling pathway(GO:0007216)
0.0 0.1 GO:0045767 obsolete regulation of anti-apoptosis(GO:0045767)
0.0 0.0 GO:0007412 axon target recognition(GO:0007412)
0.0 0.1 GO:0006516 glycoprotein catabolic process(GO:0006516)
0.0 0.0 GO:0071605 monocyte chemotactic protein-1 production(GO:0071605) regulation of monocyte chemotactic protein-1 production(GO:0071637)
0.0 0.0 GO:2000095 regulation of non-canonical Wnt signaling pathway(GO:2000050) regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000095)
0.0 0.1 GO:0006420 arginyl-tRNA aminoacylation(GO:0006420)
0.0 0.1 GO:0070572 positive regulation of axon regeneration(GO:0048680) positive regulation of neuron projection regeneration(GO:0070572)
0.0 0.0 GO:0048368 lateral mesoderm development(GO:0048368)
0.0 0.1 GO:0060014 granulosa cell differentiation(GO:0060014)
0.0 0.0 GO:0031268 pseudopodium organization(GO:0031268)
0.0 0.1 GO:0032347 regulation of ketone biosynthetic process(GO:0010566) regulation of aldosterone metabolic process(GO:0032344) regulation of aldosterone biosynthetic process(GO:0032347)
0.0 0.1 GO:0043589 skin morphogenesis(GO:0043589)
0.0 0.0 GO:0009756 carbohydrate mediated signaling(GO:0009756)
0.0 0.1 GO:0055075 potassium ion homeostasis(GO:0055075)
0.0 0.1 GO:0045793 positive regulation of cell size(GO:0045793)
0.0 0.1 GO:0030644 cellular chloride ion homeostasis(GO:0030644) chloride ion homeostasis(GO:0055064)
0.0 0.0 GO:0090047 obsolete positive regulation of transcription regulator activity(GO:0090047)
0.0 0.1 GO:0006975 DNA damage induced protein phosphorylation(GO:0006975)
0.0 0.0 GO:0071025 RNA surveillance(GO:0071025) nuclear RNA surveillance(GO:0071027) nuclear mRNA surveillance(GO:0071028)
0.0 0.0 GO:0019471 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) 4-hydroxyproline metabolic process(GO:0019471) peptidyl-proline hydroxylation(GO:0019511)
0.0 0.0 GO:0071043 CUT catabolic process(GO:0071034) CUT metabolic process(GO:0071043)
0.0 0.0 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 0.0 GO:0048170 positive regulation of long-term neuronal synaptic plasticity(GO:0048170)
0.0 0.1 GO:0070373 negative regulation of ERK1 and ERK2 cascade(GO:0070373)
0.0 0.0 GO:0061298 retina vasculature development in camera-type eye(GO:0061298) retina vasculature morphogenesis in camera-type eye(GO:0061299)
0.0 0.1 GO:0033600 negative regulation of mammary gland epithelial cell proliferation(GO:0033600)
0.0 0.1 GO:0033962 cytoplasmic mRNA processing body assembly(GO:0033962)
0.0 0.0 GO:1902339 apoptotic process involved in mammary gland involution(GO:0060057) positive regulation of apoptotic process involved in mammary gland involution(GO:0060058) positive regulation of apoptotic process involved in morphogenesis(GO:1902339) regulation of mammary gland involution(GO:1903519) positive regulation of mammary gland involution(GO:1903521) positive regulation of apoptotic process involved in development(GO:1904747)
0.0 0.1 GO:0017085 response to insecticide(GO:0017085)
0.0 0.0 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.0 0.1 GO:0006108 malate metabolic process(GO:0006108)
0.0 0.1 GO:0008655 pyrimidine-containing compound salvage(GO:0008655) pyrimidine nucleoside salvage(GO:0043097)
0.0 0.0 GO:0017121 phospholipid scrambling(GO:0017121)
0.0 0.0 GO:0045906 negative regulation of vasoconstriction(GO:0045906)
0.0 0.0 GO:0018242 protein O-linked glycosylation via serine(GO:0018242) protein O-linked glycosylation via threonine(GO:0018243)
0.0 0.1 GO:0046855 phosphorylated carbohydrate dephosphorylation(GO:0046838) inositol phosphate dephosphorylation(GO:0046855) inositol phosphate catabolic process(GO:0071545)
0.0 0.1 GO:0034446 substrate adhesion-dependent cell spreading(GO:0034446)
0.0 0.1 GO:0009223 pyrimidine deoxyribonucleotide catabolic process(GO:0009223)
0.0 0.0 GO:0019805 quinolinate biosynthetic process(GO:0019805)
0.0 0.1 GO:0006853 carnitine shuttle(GO:0006853) carnitine transmembrane transport(GO:1902603)
0.0 0.2 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)
0.0 0.0 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.0 0.1 GO:0071305 cellular response to vitamin D(GO:0071305)
0.0 0.1 GO:0009649 entrainment of circadian clock(GO:0009649)
0.0 0.0 GO:0006419 alanyl-tRNA aminoacylation(GO:0006419)
0.0 0.0 GO:0046607 positive regulation of centrosome cycle(GO:0046607)
0.0 0.1 GO:0006828 manganese ion transport(GO:0006828)
0.0 0.0 GO:0006552 leucine catabolic process(GO:0006552)
0.0 0.1 GO:0033522 histone H2A ubiquitination(GO:0033522)
0.0 0.0 GO:0007262 STAT protein import into nucleus(GO:0007262)
0.0 0.1 GO:0007090 obsolete regulation of S phase of mitotic cell cycle(GO:0007090)
0.0 0.0 GO:0021555 midbrain-hindbrain boundary morphogenesis(GO:0021555)
0.0 0.0 GO:0060999 positive regulation of dendritic spine development(GO:0060999)
0.0 0.0 GO:0033160 positive regulation of protein import into nucleus, translocation(GO:0033160)
0.0 0.1 GO:0006654 phosphatidic acid biosynthetic process(GO:0006654)
0.0 0.0 GO:0006011 UDP-glucose metabolic process(GO:0006011)
0.0 0.0 GO:0001306 age-dependent response to oxidative stress(GO:0001306) age-dependent general metabolic decline(GO:0007571)
0.0 0.1 GO:0015889 cobalamin transport(GO:0015889)
0.0 0.3 GO:0018149 peptide cross-linking(GO:0018149)
0.0 0.0 GO:0071379 cellular response to prostaglandin stimulus(GO:0071379)
0.0 0.1 GO:0048625 myoblast fate commitment(GO:0048625)
0.0 0.1 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.0 0.0 GO:0090382 phagolysosome assembly(GO:0001845) phagosome maturation(GO:0090382)
0.0 0.1 GO:0007603 phototransduction, visible light(GO:0007603)
0.0 0.1 GO:0045880 positive regulation of smoothened signaling pathway(GO:0045880)
0.0 0.0 GO:0031558 obsolete induction of apoptosis in response to chemical stimulus(GO:0031558)
0.0 0.0 GO:0009169 nucleoside monophosphate catabolic process(GO:0009125) purine nucleoside monophosphate catabolic process(GO:0009128) ribonucleoside monophosphate catabolic process(GO:0009158) purine ribonucleoside monophosphate catabolic process(GO:0009169)
0.0 0.1 GO:0060644 mammary gland epithelial cell differentiation(GO:0060644)
0.0 0.1 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.0 0.2 GO:0014075 response to amine(GO:0014075)
0.0 0.0 GO:0060997 dendritic spine morphogenesis(GO:0060997) regulation of dendritic spine morphogenesis(GO:0061001) dendritic spine organization(GO:0097061)
0.0 0.0 GO:0007352 zygotic specification of dorsal/ventral axis(GO:0007352)
0.0 0.0 GO:0003010 voluntary skeletal muscle contraction(GO:0003010) twitch skeletal muscle contraction(GO:0014721)
0.0 0.1 GO:0032055 negative regulation of translation in response to stress(GO:0032055)
0.0 0.0 GO:0003085 negative regulation of systemic arterial blood pressure(GO:0003085)
0.0 0.0 GO:0009299 mRNA transcription(GO:0009299)
0.0 0.0 GO:0040016 embryonic cleavage(GO:0040016)
0.0 0.2 GO:0045103 intermediate filament-based process(GO:0045103)
0.0 0.0 GO:0030309 poly-N-acetyllactosamine metabolic process(GO:0030309)
0.0 0.0 GO:0014912 negative regulation of smooth muscle cell migration(GO:0014912)
0.0 0.0 GO:0071318 cellular response to ATP(GO:0071318)
0.0 0.0 GO:0015870 acetylcholine transport(GO:0015870) acetate ester transport(GO:1901374)
0.0 0.0 GO:0070141 response to UV-A(GO:0070141)
0.0 0.0 GO:0021910 smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021910)
0.0 0.1 GO:0043922 negative regulation by host of viral transcription(GO:0043922)
0.0 0.1 GO:0048853 forebrain morphogenesis(GO:0048853)
0.0 0.0 GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway(GO:0040037)
0.0 0.0 GO:0009219 pyrimidine deoxyribonucleotide metabolic process(GO:0009219)
0.0 0.3 GO:0060606 neural tube closure(GO:0001843) tube closure(GO:0060606)
0.0 0.3 GO:0036503 ER-associated ubiquitin-dependent protein catabolic process(GO:0030433) ERAD pathway(GO:0036503)
0.0 0.1 GO:0050872 white fat cell differentiation(GO:0050872)
0.0 0.1 GO:0046839 phospholipid dephosphorylation(GO:0046839)
0.0 0.1 GO:0035329 hippo signaling(GO:0035329)
0.0 0.1 GO:0018200 peptidyl-glutamic acid modification(GO:0018200)
0.0 0.0 GO:0055089 fatty acid homeostasis(GO:0055089)
0.0 0.0 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.0 0.0 GO:0051877 pigment granule aggregation in cell center(GO:0051877)
0.0 0.0 GO:0072070 loop of Henle development(GO:0072070)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.1 GO:0071664 catenin-TCF7L2 complex(GO:0071664)
0.0 0.1 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.0 0.1 GO:0001940 male pronucleus(GO:0001940)
0.0 0.1 GO:0032059 bleb(GO:0032059)
0.0 0.1 GO:0000138 Golgi trans cisterna(GO:0000138)
0.0 0.1 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.1 GO:0042825 TAP complex(GO:0042825)
0.0 0.1 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.0 0.1 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.0 0.1 GO:0030061 mitochondrial crista(GO:0030061)
0.0 0.2 GO:0098642 network-forming collagen trimer(GO:0098642) collagen network(GO:0098645)
0.0 0.1 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.1 GO:0016342 catenin complex(GO:0016342)
0.0 0.1 GO:0033179 proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.0 0.1 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.0 0.1 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.2 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 0.1 GO:0036126 outer dense fiber(GO:0001520) sperm flagellum(GO:0036126)
0.0 0.1 GO:0042587 glycogen granule(GO:0042587)
0.0 0.1 GO:0070044 synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
0.0 0.1 GO:0044298 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0 0.1 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.1 GO:0031094 platelet dense tubular network(GO:0031094)
0.0 0.1 GO:0001917 photoreceptor inner segment(GO:0001917)
0.0 0.1 GO:0005721 pericentric heterochromatin(GO:0005721)
0.0 0.1 GO:0005766 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.0 0.0 GO:0071986 Ragulator complex(GO:0071986)
0.0 0.1 GO:0005915 zonula adherens(GO:0005915)
0.0 0.2 GO:0005811 lipid particle(GO:0005811)
0.0 0.1 GO:0031430 M band(GO:0031430)
0.0 0.1 GO:0005861 troponin complex(GO:0005861)
0.0 0.0 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.0 0.0 GO:0008537 proteasome activator complex(GO:0008537)
0.0 0.0 GO:0060201 clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201)
0.0 0.0 GO:0005588 collagen type V trimer(GO:0005588)
0.0 0.0 GO:0098647 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0 0.1 GO:0031143 pseudopodium(GO:0031143)
0.0 0.1 GO:0005663 DNA replication factor C complex(GO:0005663)
0.0 0.0 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 0.1 GO:0032039 integrator complex(GO:0032039)
0.0 0.1 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.1 0.2 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.1 0.2 GO:0005010 insulin-like growth factor-activated receptor activity(GO:0005010)
0.1 0.2 GO:0000293 ferric-chelate reductase activity(GO:0000293)
0.0 0.1 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.0 0.2 GO:0070215 obsolete MDM2 binding(GO:0070215)
0.0 0.1 GO:0004937 alpha1-adrenergic receptor activity(GO:0004937)
0.0 0.3 GO:0004908 interleukin-1 receptor activity(GO:0004908)
0.0 0.1 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 0.2 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.0 0.1 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.0 0.1 GO:0046980 tapasin binding(GO:0046980)
0.0 0.1 GO:0019166 trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166)
0.0 0.2 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.2 GO:0048406 nerve growth factor binding(GO:0048406)
0.0 0.1 GO:0004470 malic enzyme activity(GO:0004470)
0.0 0.1 GO:0015065 uridine nucleotide receptor activity(GO:0015065) G-protein coupled pyrimidinergic nucleotide receptor activity(GO:0071553)
0.0 0.1 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 0.2 GO:0005497 androgen binding(GO:0005497)
0.0 0.1 GO:0004117 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117)
0.0 0.3 GO:0004312 fatty acid synthase activity(GO:0004312)
0.0 0.2 GO:0042153 obsolete RPTP-like protein binding(GO:0042153)
0.0 0.1 GO:0031994 insulin-like growth factor I binding(GO:0031994)
0.0 0.1 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.0 0.1 GO:0005152 interleukin-1 receptor antagonist activity(GO:0005152)
0.0 0.2 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0 0.1 GO:0047756 chondroitin 4-sulfotransferase activity(GO:0047756)
0.0 0.1 GO:0004095 carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.0 0.1 GO:0033130 acetylcholine receptor binding(GO:0033130)
0.0 0.1 GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.0 0.1 GO:0016151 nickel cation binding(GO:0016151)
0.0 0.1 GO:0001515 opioid peptide activity(GO:0001515)
0.0 0.2 GO:0043560 insulin receptor substrate binding(GO:0043560)
0.0 0.1 GO:0015204 urea transmembrane transporter activity(GO:0015204)
0.0 0.3 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.0 0.1 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.0 0.1 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 0.1 GO:0005294 neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.0 0.2 GO:0004017 adenylate kinase activity(GO:0004017)
0.0 0.1 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.0 0.2 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.0 0.1 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0 0.1 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.0 0.1 GO:0070643 vitamin D3 25-hydroxylase activity(GO:0030343) vitamin D 25-hydroxylase activity(GO:0070643)
0.0 0.1 GO:0005042 netrin receptor activity(GO:0005042)
0.0 0.1 GO:0015194 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.0 0.1 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0 0.1 GO:0045499 chemorepellent activity(GO:0045499)
0.0 0.1 GO:0005534 galactose binding(GO:0005534)
0.0 0.1 GO:0030172 troponin C binding(GO:0030172)
0.0 0.1 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0 0.1 GO:0004969 histamine receptor activity(GO:0004969)
0.0 0.1 GO:0005384 manganese ion transmembrane transporter activity(GO:0005384)
0.0 0.1 GO:0045569 TRAIL binding(GO:0045569)
0.0 0.1 GO:0034186 apolipoprotein A-I binding(GO:0034186)
0.0 0.1 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0 0.1 GO:0035514 DNA demethylase activity(GO:0035514) DNA-N1-methyladenine dioxygenase activity(GO:0043734)
0.0 0.1 GO:0032139 dinucleotide insertion or deletion binding(GO:0032139)
0.0 0.1 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0 0.1 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0 0.1 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0 0.1 GO:0050253 retinyl-palmitate esterase activity(GO:0050253)
0.0 0.1 GO:0004982 N-formyl peptide receptor activity(GO:0004982)
0.0 0.1 GO:0004814 arginine-tRNA ligase activity(GO:0004814)
0.0 0.2 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.0 0.1 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.1 GO:0046790 virion binding(GO:0046790)
0.0 0.1 GO:0015252 hydrogen ion channel activity(GO:0015252)
0.0 0.1 GO:0000036 ACP phosphopantetheine attachment site binding involved in fatty acid biosynthetic process(GO:0000036) ACP phosphopantetheine attachment site binding(GO:0044620) prosthetic group binding(GO:0051192)
0.0 0.0 GO:0015038 glutathione disulfide oxidoreductase activity(GO:0015038)
0.0 0.1 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 0.1 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.0 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.0 0.0 GO:0050682 AF-2 domain binding(GO:0050682)
0.0 0.1 GO:0008113 peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.0 0.0 GO:0004607 phosphatidylcholine-sterol O-acyltransferase activity(GO:0004607)
0.0 0.1 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.1 GO:0070696 transmembrane receptor protein serine/threonine kinase binding(GO:0070696)
0.0 0.1 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 0.0 GO:0004813 alanine-tRNA ligase activity(GO:0004813)
0.0 0.0 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.0 0.1 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.0 0.0 GO:0047623 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0 0.1 GO:0008503 benzodiazepine receptor activity(GO:0008503)
0.0 0.1 GO:0005000 vasopressin receptor activity(GO:0005000)
0.0 0.1 GO:0005523 tropomyosin binding(GO:0005523)
0.0 0.1 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.0 GO:0008184 glycogen phosphorylase activity(GO:0008184)
0.0 0.1 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0 0.0 GO:0004738 pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.0 0.1 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.0 0.1 GO:0030506 ankyrin binding(GO:0030506)
0.0 0.0 GO:0003680 AT DNA binding(GO:0003680)
0.0 0.0 GO:0001849 complement component C1q binding(GO:0001849)
0.0 0.0 GO:0004461 lactose synthase activity(GO:0004461)
0.0 0.0 GO:0015421 oligopeptide-transporting ATPase activity(GO:0015421)
0.0 0.1 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0 0.1 GO:0015057 thrombin receptor activity(GO:0015057)
0.0 0.1 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 0.0 GO:0046848 hydroxyapatite binding(GO:0046848)
0.0 0.0 GO:0016509 long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0016509)
0.0 0.0 GO:0016454 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0 0.0 GO:0008900 hydrogen:potassium-exchanging ATPase activity(GO:0008900)
0.0 0.1 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0 0.0 GO:0043398 HLH domain binding(GO:0043398)
0.0 0.1 GO:0051787 misfolded protein binding(GO:0051787)
0.0 0.0 GO:0005148 prolactin receptor binding(GO:0005148)
0.0 0.1 GO:0015250 water channel activity(GO:0015250)
0.0 0.0 GO:0004367 glycerol-3-phosphate dehydrogenase [NAD+] activity(GO:0004367)
0.0 0.2 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.1 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.0 0.1 GO:0015643 toxic substance binding(GO:0015643)
0.0 0.0 GO:0008486 diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486)
0.0 0.1 GO:0015520 tetracycline:proton antiporter activity(GO:0015520)
0.0 0.0 GO:0019215 intermediate filament binding(GO:0019215)
0.0 0.1 GO:0005110 frizzled-2 binding(GO:0005110)
0.0 0.1 GO:0005521 lamin binding(GO:0005521)
0.0 0.0 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0 0.1 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.0 0.3 GO:0030145 manganese ion binding(GO:0030145)
0.0 0.0 GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.0 0.0 GO:0050897 cobalt ion binding(GO:0050897)
0.0 0.1 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.1 GO:0016595 glutamate binding(GO:0016595)
0.0 0.0 GO:0055077 gap junction hemi-channel activity(GO:0055077)
0.0 0.1 GO:0008649 rRNA methyltransferase activity(GO:0008649)
0.0 0.1 GO:0030169 low-density lipoprotein particle binding(GO:0030169)
0.0 0.1 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0 0.0 GO:0033765 steroid dehydrogenase activity, acting on the CH-CH group of donors(GO:0033765)
0.0 0.1 GO:0016713 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen(GO:0016713)
0.0 0.0 GO:0042289 MHC class II protein binding(GO:0042289)
0.0 0.0 GO:0034711 inhibin binding(GO:0034711)
0.0 0.0 GO:0004594 pantothenate kinase activity(GO:0004594)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.0 0.0 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 0.1 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 0.0 ST GA12 PATHWAY G alpha 12 Pathway
0.0 0.1 ST INTEGRIN SIGNALING PATHWAY Integrin Signaling Pathway
0.0 0.1 PID NETRIN PATHWAY Netrin-mediated signaling events
0.0 0.4 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.0 0.0 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
0.0 0.5 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 0.3 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.0 0.3 PID S1P S1P2 PATHWAY S1P2 pathway
0.0 0.4 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions
0.0 0.0 PID PI3KCI AKT PATHWAY Class I PI3K signaling events mediated by Akt
0.0 0.1 PID AR NONGENOMIC PATHWAY Nongenotropic Androgen signaling
0.0 0.2 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 0.2 PID ERBB NETWORK PATHWAY ErbB receptor signaling network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.1 REACTOME DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR Genes involved in Downstream Signaling Events Of B Cell Receptor (BCR)
0.0 0.3 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.0 0.1 REACTOME PLATELET AGGREGATION PLUG FORMATION Genes involved in Platelet Aggregation (Plug Formation)
0.0 0.5 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.2 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 0.0 REACTOME ARMS MEDIATED ACTIVATION Genes involved in ARMS-mediated activation
0.0 0.0 REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0 0.3 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.0 REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 Genes involved in Signaling by activated point mutants of FGFR1
0.0 0.1 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 0.2 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.0 0.2 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0 0.0 REACTOME PLC BETA MEDIATED EVENTS Genes involved in PLC beta mediated events
0.0 0.0 REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL Genes involved in NF-kB is activated and signals survival
0.0 0.3 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.0 0.2 REACTOME POL SWITCHING Genes involved in Polymerase switching
0.0 0.2 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.0 0.2 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 0.1 REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP Genes involved in Destabilization of mRNA by Tristetraprolin (TTP)
0.0 0.3 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.2 REACTOME ENDOGENOUS STEROLS Genes involved in Endogenous sterols
0.0 0.1 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.0 REACTOME NEF MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS Genes involved in Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
0.0 0.2 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 0.0 REACTOME BOTULINUM NEUROTOXICITY Genes involved in Botulinum neurotoxicity
0.0 0.0 REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.0 0.2 REACTOME GRB2 EVENTS IN ERBB2 SIGNALING Genes involved in GRB2 events in ERBB2 signaling
0.0 0.1 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
0.0 0.1 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.0 REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS Genes involved in CREB phosphorylation through the activation of Ras
0.0 0.1 REACTOME G PROTEIN ACTIVATION Genes involved in G-protein activation
0.0 0.2 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.1 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.2 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.0 0.1 REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.0 0.0 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 0.2 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.0 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.1 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.0 0.2 REACTOME ACYL CHAIN REMODELLING OF PC Genes involved in Acyl chain remodelling of PC
0.0 0.1 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions