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ENCODE: H3K4me1 ChIP-Seq of primary human cells
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Results for NKX2-6

Z-value: 1.37

Motif logo

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Transcription factors associated with NKX2-6

Gene Symbol Gene ID Gene Info
NKX2-6
ENSG00000180053.6 NK2 homeobox 6

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr8_23553705_23553856NKX2-6101420.1574800.531.4e-01Click!
chr8_23554046_23554197NKX2-698010.1581950.491.8e-01Click!
chr8_23563753_23563904NKX2-6940.925228-0.422.6e-01Click!
chr8_23563478_23563629NKX2-63690.766455-0.412.7e-01Click!
chr8_23560501_23560652NKX2-633460.200322-0.373.3e-01Click!

Activity of the NKX2-6 motif across conditions

Conditions sorted by the z-value of the NKX2-6 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr9_16540961_16541659 0.62 RP11-183I6.2
68124
 0.12
chr11_73990200_73990857 0.49 ENSG00000206913
 .
 26931
 0.14
chr22_40830866_40831668 0.48 RP5-1042K10.13
20260
 0.14
chr21_35918859_35919211 0.46 RCAN1
 regulator of calcineurin 1
 13442
 0.2
chr3_45687605_45688015 0.44 LIMD1-AS1
 LIMD1 antisense RNA 1
 42564
 0.12
chr15_71060497_71060707 0.43 UACA
 uveal autoantigen with coiled-coil domains and ankyrin repeats
 4670
 0.23
chr2_37947734_37948100 0.39 CDC42EP3
 CDC42 effector protein (Rho GTPase binding) 3
 17694
 0.27
chr1_77941867_77942099 0.38 AK5
 adenylate kinase 5
 55809
 0.12
chr8_125192495_125192646 0.38 FER1L6-AS2
 FER1L6 antisense RNA 2
 8807
 0.26
chr2_217354341_217354722 0.37 AC098820.4
2612
 0.22
chr12_63122687_63123266 0.36 ENSG00000238475
 .
 78021
 0.09
chr2_172388783_172388934 0.35 CYBRD1
 cytochrome b reductase 1
 9269
 0.25
chr2_145263610_145263985 0.34 ZEB2
 zinc finger E-box binding homeobox 2
 11318
 0.24
chr17_32574614_32574944 0.34 CCL2
 chemokine (C-C motif) ligand 2
 7525
 0.13
chr20_17629504_17629678 0.33 RRBP1
 ribosome binding protein 1
 11561
 0.2
chr1_86458784_86459076 0.33 ENSG00000201620
 .
 109449
 0.07
chr14_100376642_100376793 0.33 EML1
 echinoderm microtubule associated protein like 1
 12147
 0.2
chr3_38871334_38871622 0.33 RP11-134J21.1
6085
 0.2
chr7_81396029_81396416 0.33 HGF
 hepatocyte growth factor (hepapoietin A; scatter factor)
 3065
 0.4
chr8_134244229_134244380 0.33 WISP1-OT1
 WISP1 overlapping transcript 1 (non-protein coding)
 3005
 0.31
chr20_9063656_9063954 0.33 PLCB4
 phospholipase C, beta 4
 14057
 0.24
chr13_31294257_31294613 0.33 ALOX5AP
 arachidonate 5-lipoxygenase-activating protein
 15210
 0.26
chr10_3856587_3856738 0.33 KLF6
 Kruppel-like factor 6
 29189
 0.2
chr10_29130225_29130376 0.33 C10orf126
 chromosome 10 open reading frame 126
 5037
 0.26
chr10_54412447_54412741 0.32 RP11-556E13.1
91729
 0.09
chr16_78719280_78719578 0.32 RP11-264L1.3
151158
 0.04
chr8_129054673_129054878 0.32 ENSG00000221176
 .
 6623
 0.21
chr5_111115219_111115750 0.32 NREP
 neuronal regeneration related protein
 21569
 0.21
chr9_86786252_86786403 0.32 RP11-380F14.2
106807
 0.06
chr15_80271357_80271985 0.32 BCL2A1
 BCL2-related protein A1
 7883
 0.2
chr14_71839341_71839562 0.32 ENSG00000207444
 .
 25603
 0.19
chr6_143281120_143281272 0.31 HIVEP2
 human immunodeficiency virus type I enhancer binding protein 2
 14858
 0.23
chr7_13959398_13959662 0.31 ETV1
 ets variant 1
 66536
 0.14
chr1_225942912_225943116 0.31 ENSG00000223306
 .
 14037
 0.14
chr15_99271535_99272053 0.31 IGF1R
 insulin-like growth factor 1 receptor
 20734
 0.22
chr1_192988213_192988364 0.31 UCHL5
 ubiquitin carboxyl-terminal hydrolase L5
 4764
 0.21
chr12_29752319_29752470 0.31 TMTC1
 transmembrane and tetratricopeptide repeat containing 1
 4763
 0.31
chr17_9249524_9249871 0.31 RP11-85B7.4
63206
 0.12
chr5_158126612_158126763 0.30 CTD-2363C16.1
283327
 0.01
chr5_158448429_158448934 0.30 CTD-2363C16.2
35867
 0.17
chr12_109042760_109042911 0.30 CORO1C
 coronin, actin binding protein, 1C
 3286
 0.17
chr10_97047482_97047633 0.30 PDLIM1
 PDZ and LIM domain 1
 3224
 0.31
chr3_45684381_45684734 0.30 LIMD1-AS1
 LIMD1 antisense RNA 1
 45817
 0.11
chr8_96715315_96715466 0.30 ENSG00000223297
 .
 24247
 0.26
chr12_2494439_2494710 0.30 CACNA1C-IT3
 CACNA1C intronic transcript 3 (non-protein coding)
 115632
 0.06
chr12_88756954_88757105 0.30 ENSG00000199245
 .
 67190
 0.14
chr2_192116508_192116659 0.30 MYO1B
 myosin IB
 5574
 0.29
chr3_45589006_45589723 0.30 LARS2-AS1
 LARS2 antisense RNA 1
 38327
 0.14
chr1_97004836_97004987 0.30 ENSG00000241992
 .
 43854
 0.2
chr1_68187782_68188175 0.29 GADD45A
 growth arrest and DNA-damage-inducible, alpha
 37094
 0.16
chr11_121961832_121961983 0.29 ENSG00000207971
 .
 8645
 0.17
chr15_67065770_67066102 0.29 SMAD6
 SMAD family member 6
 61901
 0.13
chr20_23132592_23133523 0.29 ENSG00000201527
 .
 8551
 0.22
chr1_200337482_200337689 0.29 ZNF281
 zinc finger protein 281
 41535
 0.21
chr1_178055842_178055993 0.29 RASAL2
 RAS protein activator like 2
 6947
 0.32
chr7_76867154_76867700 0.29 AC073635.5
20013
 0.2
chr2_55339476_55339889 0.29 RTN4
 reticulon 4
 75
 0.97
chr8_122001527_122001678 0.29 ENSG00000252093
 .
 80026
 0.11
chr17_47076838_47077332 0.29 IGF2BP1
 insulin-like growth factor 2 mRNA binding protein 1
 1977
 0.17
chr16_67274601_67274968 0.29 SLC9A5
 solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5
 6034
 0.08
chr8_105689851_105690002 0.28 ENSG00000263732
 .
 77477
 0.1
chr10_77290347_77290581 0.28 ENSG00000207583
 .
 21752
 0.23
chr13_27157989_27158140 0.28 WASF3
 WAS protein family, member 3
 26177
 0.23
chr12_20543454_20543605 0.28 RP11-284H19.1
20333
 0.23
chr6_52467732_52468424 0.28 TRAM2
 translocation associated membrane protein 2
 26365
 0.19
chr1_219299907_219300058 0.28 LYPLAL1
 lysophospholipase-like 1
 47204
 0.17
chr1_211775743_211775938 0.28 RP11-359E8.5
18773
 0.16
chr7_17001293_17001444 0.28 AGR3
 anterior gradient 3
 79757
 0.1
chr4_157895789_157896050 0.27 PDGFC
 platelet derived growth factor C
 3373
 0.27
chr4_157416635_157416786 0.27 RP11-171N4.2
 Uncharacterized protein
 146749
 0.04
chr1_61370549_61370700 0.27 NFIA
 nuclear factor I/A
 39693
 0.19
chr20_40138790_40139006 0.27 CHD6
 chromodomain helicase DNA binding protein 6
 10941
 0.28
chr13_30095383_30095797 0.27 MTUS2-AS1
 MTUS2 antisense RNA 1
 31348
 0.21
chr1_17448827_17448978 0.27 PADI2
 peptidyl arginine deiminase, type II
 2954
 0.25
chr6_133032333_133032512 0.27 VNN1
 vanin 1
 2766
 0.21
chr4_14061132_14061426 0.27 ENSG00000252092
 .
 401028
 0.01
chr4_88296347_88296610 0.27 ENSG00000240966
 .
 11848
 0.15
chr17_53504679_53504830 0.27 MMD
 monocyte to macrophage differentiation-associated
 5401
 0.32
chr3_67047069_67047341 0.27 KBTBD8
 kelch repeat and BTB (POZ) domain containing 8
 1522
 0.59
chr11_2324783_2325431 0.27 TSPAN32
 tetraspanin 32
 1009
 0.38
chr10_44958607_44958758 0.27 CXCL12
 chemokine (C-X-C motif) ligand 12
 78142
 0.11
chr17_67139065_67139216 0.26 ABCA6
 ATP-binding cassette, sub-family A (ABC1), member 6
 1111
 0.51
chr5_34524127_34524278 0.26 RAI14
 retinoic acid induced 14
 132140
 0.05
chr4_157860965_157861230 0.26 PDGFC
 platelet derived growth factor C
 30958
 0.19
chr15_40171438_40171589 0.26 GPR176
 G protein-coupled receptor 176
 40913
 0.11
chr2_153469749_153469919 0.26 FMNL2
 formin-like 2
 6258
 0.31
chr7_137557971_137558230 0.26 DGKI
 diacylglycerol kinase, iota
 26262
 0.2
chr2_40354084_40354235 0.26 SLC8A1-AS1
 SLC8A1 antisense RNA 1
 11990
 0.31
chr7_137628746_137628897 0.26 AC022173.2
9273
 0.21
chr4_120439477_120439628 0.26 PDE5A
 phosphodiesterase 5A, cGMP-specific
 702
 0.73
chr6_123032140_123032424 0.26 PKIB
 protein kinase (cAMP-dependent, catalytic) inhibitor beta
 6424
 0.24
chr17_74711629_74712064 0.26 MXRA7
 matrix-remodelling associated 7
 4748
 0.09
chr3_171283226_171283448 0.26 ENSG00000207114
 .
 61197
 0.13
chr7_120633768_120634071 0.26 CPED1
 cadherin-like and PC-esterase domain containing 1
 4243
 0.23
chr10_93871030_93871181 0.26 ENSG00000252993
 .
 35106
 0.16
chr1_101093719_101093870 0.26 GPR88
 G protein-coupled receptor 88
 90101
 0.08
chr1_21451523_21451771 0.26 EIF4G3
 eukaryotic translation initiation factor 4 gamma, 3
 35946
 0.17
chr2_200603538_200603689 0.26 FTCDNL1
 formiminotransferase cyclodeaminase N-terminal like
 111983
 0.07
chr5_33369882_33370033 0.26 CTD-2203K17.1
70768
 0.12
chr5_138875477_138875767 0.26 TMEM173
 transmembrane protein 173
 13247
 0.13
chr6_82472333_82472746 0.26 ENSG00000206886
 .
 1202
 0.5
chr12_13270933_13271084 0.25 GSG1
 germ cell associated 1
 14389
 0.21
chr12_93770029_93770180 0.25 RP11-486A14.2
1380
 0.31
chr4_26143484_26143734 0.25 RBPJ
 recombination signal binding protein for immunoglobulin kappa J region
 21468
 0.28
chr6_110417870_110418143 0.25 WASF1
 WAS protein family, member 1
 82846
 0.09
chr15_71625454_71625605 0.25 RP11-592N21.2
9134
 0.29
chr10_5504056_5504535 0.25 NET1
 neuroepithelial cell transforming 1
 15721
 0.15
chr6_35185894_35186601 0.25 SCUBE3
 signal peptide, CUB domain, EGF-like 3
 4051
 0.24
chr2_210337616_210337973 0.25 MAP2
 microtubule-associated protein 2
 49012
 0.19
chr5_124820297_124820570 0.25 ENSG00000222107
 .
 133609
 0.06
chr10_92681329_92681480 0.25 ANKRD1
 ankyrin repeat domain 1 (cardiac muscle)
 371
 0.79
chr7_29905918_29906329 0.25 WIPF3
 WAS/WASL interacting protein family, member 3
 31782
 0.17
chr10_31550924_31551075 0.25 ENSG00000252479
 .
 2471
 0.35
chr7_114627811_114627962 0.25 MDFIC
 MyoD family inhibitor domain containing
 53962
 0.18
chr1_29528780_29529144 0.25 SRSF4
 serine/arginine-rich splicing factor 4
 20463
 0.13
chr1_235104740_235105149 0.25 ENSG00000239690
 .
 65011
 0.12
chr11_121965409_121965560 0.25 ENSG00000207971
 .
 5068
 0.18
chr4_186837108_186837259 0.25 ENSG00000239034
 .
 30054
 0.18
chr7_41517588_41517820 0.25 INHBA-AS1
 INHBA antisense RNA 1
 215810
 0.02
chr8_98983880_98984031 0.25 MATN2
 matrilin 2
 10245
 0.2
chr2_218550468_218550619 0.25 DIRC3
 disrupted in renal carcinoma 3
 70735
 0.12
chr15_51225693_51226195 0.25 AP4E1
 adaptor-related protein complex 4, epsilon 1 subunit
 24952
 0.23
chr7_76855540_76855691 0.25 FGL2
 fibrinogen-like 2
 26472
 0.18
chr10_91921633_91921784 0.25 ENSG00000222451
 .
 2009
 0.5
chr7_80264399_80264550 0.25 CD36
 CD36 molecule (thrombospondin receptor)
 3486
 0.37
chr6_131428128_131428279 0.25 AKAP7
 A kinase (PRKA) anchor protein 7
 28603
 0.22
chr2_183283239_183283390 0.25 PDE1A
 phosphodiesterase 1A, calmodulin-dependent
 8435
 0.3
chr8_59966515_59966743 0.25 RP11-328K2.1
61132
 0.11
chr12_104518100_104518251 0.25 ENSG00000199415
 .
 839
 0.6
chr2_43303903_43304168 0.25 ENSG00000207087
 .
 14597
 0.28
chr2_226982606_226982904 0.25 ENSG00000263363
 .
 540754
 0.0
chr2_26661594_26661750 0.25 DRC1
 dynein regulatory complex subunit 1 homolog (Chlamydomonas)
 8315
 0.21
chr10_3902800_3902951 0.25 KLF6
 Kruppel-like factor 6
 75402
 0.11
chr20_2839933_2840363 0.24 VPS16
 vacuolar protein sorting 16 homolog (S. cerevisiae)
 2955
 0.18
chr8_104117881_104118032 0.24 ENSG00000265667
 .
 13007
 0.13
chr5_114915172_114915323 0.24 AC010226.4
22507
 0.14
chr7_33948512_33948663 0.24 BMPER
 BMP binding endothelial regulator
 3442
 0.38
chr17_30070933_30071094 0.24 ENSG00000202026
 .
 30241
 0.18
chr17_36586871_36587022 0.24 ARHGAP23
 Rho GTPase activating protein 23
 2216
 0.26
chr1_10441222_10441373 0.24 ENSG00000265945
 .
 8762
 0.13
chr4_169652420_169652571 0.24 PALLD
 palladin, cytoskeletal associated protein
 19185
 0.21
chr8_108314695_108314915 0.24 ANGPT1
 angiopoietin 1
 33945
 0.21
chr2_144711401_144711552 0.24 AC016910.1
16836
 0.25
chr7_48285699_48285984 0.24 ABCA13
 ATP-binding cassette, sub-family A (ABC1), member 13
 74784
 0.12
chr5_125351586_125351737 0.24 ENSG00000265637
 .
 180867
 0.03
chr18_455946_456097 0.24 RP11-720L2.2
31605
 0.16
chr6_82454549_82454764 0.24 FAM46A
 family with sequence similarity 46, member A
 6814
 0.2
chr6_127514210_127514472 0.24 RNF146
 ring finger protein 146
 73414
 0.11
chr7_134574979_134575413 0.24 CALD1
 caldesmon 1
 955
 0.69
chr18_46238546_46238697 0.24 RP11-426J5.2
23831
 0.21
chr9_110399429_110399916 0.24 ENSG00000202308
 .
 25855
 0.23
chr12_20061614_20061845 0.24 ENSG00000221679
 .
 64070
 0.15
chr17_29894018_29894169 0.24 ENSG00000221038
 .
 3180
 0.14
chr13_50783531_50783810 0.24 DLEU1
 deleted in lymphocytic leukemia 1 (non-protein coding)
 127363
 0.05
chr11_34367020_34367283 0.24 ABTB2
 ankyrin repeat and BTB (POZ) domain containing 2
 11651
 0.26
chr1_56162477_56162628 0.24 ENSG00000272051
 .
 211907
 0.02
chr11_122556790_122557092 0.24 UBASH3B
 ubiquitin associated and SH3 domain containing B
 30558
 0.18
chr2_69464357_69464627 0.24 ENSG00000199460
 .
 54483
 0.12
chr1_180000870_180001021 0.24 CEP350
 centrosomal protein 350kDa
 9393
 0.26
chr7_41518329_41518480 0.24 INHBA-AS1
 INHBA antisense RNA 1
 215110
 0.02
chr4_16780959_16781110 0.24 LDB2
 LIM domain binding 2
 105098
 0.08
chr7_100016771_100016922 0.24 ZCWPW1
 zinc finger, CW type with PWWP domain 1
 654
 0.47
chr12_109117281_109117726 0.24 CORO1C
 coronin, actin binding protein, 1C
 6824
 0.16
chr3_99681966_99682117 0.24 ENSG00000264897
 .
 1201
 0.6
chr3_45100675_45100826 0.24 ENSG00000252410
 .
 24670
 0.16
chr18_18744847_18745057 0.24 ENSG00000251886
 .
 44485
 0.15
chr3_123509920_123510071 0.24 MYLK
 myosin light chain kinase
 2693
 0.3
chr3_177649836_177649987 0.23 ENSG00000199858
 .
 75656
 0.13
chr8_104241607_104241758 0.23 RP11-318M2.3
140
 0.96
chr12_127768981_127769132 0.23 ENSG00000253089
 .
 36844
 0.23
chr12_66455744_66455895 0.23 ENSG00000251857
 .
 4182
 0.25
chr8_23381826_23381979 0.23 SLC25A37
 solute carrier family 25 (mitochondrial iron transporter), member 37
 4416
 0.2
chr6_116733337_116733739 0.23 DSE
 dermatan sulfate epimerase
 41428
 0.1
chr11_12841613_12841764 0.23 RP11-47J17.3
3526
 0.26
chr10_3591240_3591463 0.23 RP11-184A2.3
201908
 0.03
chr1_109936676_109936954 0.23 SORT1
 sortilin 1
 836
 0.57
chr4_106117299_106117679 0.23 TET2-AS1
 TET2 antisense RNA 1
 18269
 0.22
chr3_179435405_179435556 0.23 USP13
 ubiquitin specific peptidase 13 (isopeptidase T-3)
 3872
 0.28
chr10_99478408_99478800 0.23 MARVELD1
 MARVEL domain containing 1
 5123
 0.17
chr6_11522959_11523110 0.23 TMEM170B
 transmembrane protein 170B
 14904
 0.22
chr9_129135479_129135756 0.23 MVB12B
 multivesicular body subunit 12B
 3105
 0.29
chr12_27701552_27701930 0.23 PPFIBP1
 PTPRF interacting protein, binding protein 1 (liprin beta 1)
 10685
 0.23
chr14_30392743_30392894 0.23 PRKD1
 protein kinase D1
 4030
 0.28
chr16_57142254_57142881 0.23 CPNE2
 copine II
 1896
 0.27
chrX_18979389_18979540 0.23 PHKA2
 phosphorylase kinase, alpha 2 (liver)
 23252
 0.19
chr13_27540158_27540309 0.23 USP12-AS1
 USP12 antisense RNA 1
 196759
 0.02
chr12_66050364_66050557 0.23 HMGA2
 high mobility group AT-hook 2
 167451
 0.03
chr11_67781235_67781527 0.23 ALDH3B1
 aldehyde dehydrogenase 3 family, member B1
 3591
 0.13
chr6_113396081_113396232 0.23 ENSG00000201386
 .
 103461
 0.08
chr7_34078618_34078769 0.23 BMPER
 BMP binding endothelial regulator
 133548
 0.05
chr6_132455519_132455670 0.23 ENSG00000265669
 .
 19191
 0.27
chr1_25119704_25119971 0.23 ENSG00000238482
 .
 15367
 0.21
chr4_141031157_141031308 0.23 RP11-392B6.1
17937
 0.23
chr13_60265756_60265907 0.23 ENSG00000239003
 .
 211627
 0.02
chr1_178599347_178599498 0.23 ENSG00000266417
 .
 47462
 0.12
chr10_31888840_31889209 0.23 ENSG00000222412
 .
 156040
 0.04
chr3_12750431_12750810 0.23 TMEM40
 transmembrane protein 40
 33396
 0.14
chr3_30204653_30204804 0.23 ENSG00000266546
 .
 24204
 0.21
chr4_74698717_74699078 0.23 CXCL6
 chemokine (C-X-C motif) ligand 6
 3317
 0.2
chr3_113345260_113345597 0.23 ENSG00000241529
 .
 6123
 0.18

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX2-6

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.1 0.3 GO:0021801 cerebral cortex radial glia guided migration(GO:0021801) telencephalon glial cell migration(GO:0022030)
0.1 0.1 GO:0060028 convergent extension involved in axis elongation(GO:0060028)
0.1 0.2 GO:0060831 smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:0060831)
0.1 0.3 GO:0048149 behavioral response to ethanol(GO:0048149)
0.1 0.3 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.1 0.2 GO:0070874 negative regulation of glycogen metabolic process(GO:0070874)
0.1 0.2 GO:0070050 neuron cellular homeostasis(GO:0070050)
0.1 0.2 GO:0000103 sulfate assimilation(GO:0000103)
0.1 0.2 GO:0001996 positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996)
0.1 0.2 GO:0030091 protein repair(GO:0030091)
0.1 0.3 GO:0032277 negative regulation of gonadotropin secretion(GO:0032277)
0.1 0.2 GO:0071277 cellular response to calcium ion(GO:0071277)
0.1 0.2 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.1 0.2 GO:1900115 sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.1 0.1 GO:0048245 eosinophil chemotaxis(GO:0048245) eosinophil migration(GO:0072677)
0.1 0.1 GO:0060449 bud elongation involved in lung branching(GO:0060449)
0.1 0.2 GO:0055098 response to low-density lipoprotein particle(GO:0055098)
0.1 0.3 GO:0006910 phagocytosis, recognition(GO:0006910)
0.1 0.2 GO:0043589 skin morphogenesis(GO:0043589)
0.1 0.1 GO:0060648 mammary gland bud morphogenesis(GO:0060648)
0.0 0.3 GO:0070098 chemokine-mediated signaling pathway(GO:0070098)
0.0 0.1 GO:0010842 retina layer formation(GO:0010842)
0.0 0.0 GO:0043117 positive regulation of vascular permeability(GO:0043117)
0.0 0.2 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
0.0 0.2 GO:0051497 negative regulation of stress fiber assembly(GO:0051497)
0.0 0.1 GO:0006065 UDP-glucuronate biosynthetic process(GO:0006065)
0.0 0.1 GO:0048669 collateral sprouting in absence of injury(GO:0048669)
0.0 0.1 GO:0030538 embryonic genitalia morphogenesis(GO:0030538)
0.0 0.2 GO:0018101 protein citrullination(GO:0018101)
0.0 0.1 GO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.0 0.0 GO:0060242 contact inhibition(GO:0060242)
0.0 0.2 GO:0097061 dendritic spine morphogenesis(GO:0060997) regulation of dendritic spine morphogenesis(GO:0061001) dendritic spine organization(GO:0097061)
0.0 0.2 GO:0071731 response to nitric oxide(GO:0071731)
0.0 0.2 GO:0060753 mast cell chemotaxis(GO:0002551) regulation of mast cell chemotaxis(GO:0060753) positive regulation of mast cell chemotaxis(GO:0060754) mast cell migration(GO:0097531)
0.0 0.3 GO:0045652 regulation of megakaryocyte differentiation(GO:0045652) regulation of hematopoietic progenitor cell differentiation(GO:1901532)
0.0 0.1 GO:0060638 mesenchymal-epithelial cell signaling(GO:0060638)
0.0 0.1 GO:0048702 embryonic neurocranium morphogenesis(GO:0048702)
0.0 0.1 GO:0035234 ectopic germ cell programmed cell death(GO:0035234)
0.0 0.2 GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0 0.1 GO:0045343 MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343)
0.0 0.1 GO:0055089 fatty acid homeostasis(GO:0055089)
0.0 0.2 GO:0060180 regulation of female receptivity(GO:0045924) female mating behavior(GO:0060180)
0.0 0.2 GO:0001547 antral ovarian follicle growth(GO:0001547)
0.0 0.1 GO:0010766 negative regulation of sodium ion transport(GO:0010766)
0.0 0.1 GO:0072311 renal filtration cell differentiation(GO:0061318) glomerular epithelium development(GO:0072010) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.0 0.1 GO:0032926 negative regulation of activin receptor signaling pathway(GO:0032926)
0.0 0.2 GO:0033327 Leydig cell differentiation(GO:0033327)
0.0 0.1 GO:0045425 positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process(GO:0045425)
0.0 0.1 GO:0006654 phosphatidic acid biosynthetic process(GO:0006654)
0.0 0.1 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
0.0 0.1 GO:0032509 endosome transport via multivesicular body sorting pathway(GO:0032509)
0.0 0.1 GO:1903053 regulation of extracellular matrix disassembly(GO:0010715) negative regulation of extracellular matrix disassembly(GO:0010716) regulation of extracellular matrix organization(GO:1903053) negative regulation of extracellular matrix organization(GO:1903054)
0.0 0.0 GO:0042661 regulation of mesodermal cell fate specification(GO:0042661) regulation of mesoderm development(GO:2000380)
0.0 0.1 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.0 0.1 GO:0016102 retinoic acid biosynthetic process(GO:0002138) diterpenoid biosynthetic process(GO:0016102)
0.0 0.1 GO:0051305 chromosome movement towards spindle pole(GO:0051305)
0.0 0.2 GO:0031017 exocrine pancreas development(GO:0031017)
0.0 0.1 GO:0034393 positive regulation of muscle cell apoptotic process(GO:0010661) positive regulation of smooth muscle cell apoptotic process(GO:0034393)
0.0 0.2 GO:0032462 regulation of protein homooligomerization(GO:0032462)
0.0 0.1 GO:0017121 phospholipid scrambling(GO:0017121)
0.0 0.1 GO:0033962 cytoplasmic mRNA processing body assembly(GO:0033962)
0.0 0.1 GO:0007406 negative regulation of neuroblast proliferation(GO:0007406) negative regulation of neural precursor cell proliferation(GO:2000178)
0.0 0.1 GO:0032344 regulation of ketone biosynthetic process(GO:0010566) regulation of aldosterone metabolic process(GO:0032344) regulation of aldosterone biosynthetic process(GO:0032347)
0.0 0.1 GO:0007028 cytoplasm organization(GO:0007028)
0.0 0.2 GO:0015840 urea transport(GO:0015840)
0.0 0.0 GO:0060197 cloaca development(GO:0035844) cloacal septation(GO:0060197)
0.0 0.1 GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.0 0.1 GO:2000095 regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000095)
0.0 0.2 GO:0070875 positive regulation of glycogen biosynthetic process(GO:0045725) positive regulation of glycogen metabolic process(GO:0070875)
0.0 0.1 GO:0016322 neuron remodeling(GO:0016322)
0.0 0.1 GO:0008300 isoprenoid catabolic process(GO:0008300)
0.0 0.1 GO:0010815 bradykinin catabolic process(GO:0010815)
0.0 0.1 GO:0070561 vitamin D receptor signaling pathway(GO:0070561)
0.0 0.0 GO:0060083 smooth muscle contraction involved in micturition(GO:0060083)
0.0 0.1 GO:0018242 protein O-linked glycosylation via serine(GO:0018242) protein O-linked glycosylation via threonine(GO:0018243)
0.0 0.1 GO:0015911 plasma membrane long-chain fatty acid transport(GO:0015911)
0.0 0.1 GO:0060129 thyroid-stimulating hormone-secreting cell differentiation(GO:0060129)
0.0 0.1 GO:0050774 negative regulation of dendrite morphogenesis(GO:0050774)
0.0 0.2 GO:0043097 pyrimidine-containing compound salvage(GO:0008655) pyrimidine nucleoside salvage(GO:0043097)
0.0 0.1 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
0.0 0.2 GO:0015871 choline transport(GO:0015871)
0.0 0.1 GO:0006048 UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.0 0.0 GO:0003321 positive regulation of blood pressure by epinephrine-norepinephrine(GO:0003321)
0.0 0.1 GO:0045715 negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715)
0.0 0.0 GO:0001992 regulation of systemic arterial blood pressure by vasopressin(GO:0001992)
0.0 0.1 GO:0048630 skeletal muscle tissue growth(GO:0048630)
0.0 0.1 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.0 0.1 GO:0045992 negative regulation of embryonic development(GO:0045992)
0.0 0.1 GO:0060841 venous blood vessel development(GO:0060841)
0.0 0.0 GO:0021670 lateral ventricle development(GO:0021670)
0.0 0.1 GO:0008228 opsonization(GO:0008228)
0.0 0.0 GO:0001543 ovarian follicle rupture(GO:0001543)
0.0 0.0 GO:0060433 bronchus development(GO:0060433)
0.0 0.1 GO:0010193 response to ozone(GO:0010193)
0.0 0.1 GO:0008215 spermine metabolic process(GO:0008215)
0.0 0.0 GO:0002689 negative regulation of leukocyte chemotaxis(GO:0002689)
0.0 0.0 GO:0002887 negative regulation of myeloid leukocyte mediated immunity(GO:0002887) negative regulation of leukocyte degranulation(GO:0043301)
0.0 0.0 GO:0040019 positive regulation of embryonic development(GO:0040019)
0.0 0.0 GO:0010936 negative regulation of macrophage cytokine production(GO:0010936)
0.0 0.0 GO:0070141 response to UV-A(GO:0070141)
0.0 0.1 GO:0051124 synaptic growth at neuromuscular junction(GO:0051124)
0.0 0.1 GO:0033008 positive regulation of mast cell activation involved in immune response(GO:0033008) positive regulation of leukocyte degranulation(GO:0043302) positive regulation of mast cell degranulation(GO:0043306)
0.0 0.1 GO:0045793 positive regulation of cell size(GO:0045793)
0.0 0.1 GO:0022601 menstrual cycle phase(GO:0022601)
0.0 0.1 GO:0031641 regulation of myelination(GO:0031641)
0.0 0.1 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 0.1 GO:0007343 egg activation(GO:0007343)
0.0 0.3 GO:0021846 cell proliferation in forebrain(GO:0021846)
0.0 0.0 GO:0048680 positive regulation of axon regeneration(GO:0048680) positive regulation of neuron projection regeneration(GO:0070572)
0.0 0.1 GO:0071360 cellular response to exogenous dsRNA(GO:0071360)
0.0 0.0 GO:0045721 negative regulation of gluconeogenesis(GO:0045721)
0.0 0.0 GO:0033860 regulation of NAD(P)H oxidase activity(GO:0033860)
0.0 0.2 GO:0048844 artery morphogenesis(GO:0048844)
0.0 0.1 GO:0090073 positive regulation of protein homodimerization activity(GO:0090073)
0.0 0.1 GO:0036465 synaptic vesicle recycling(GO:0036465) synaptic vesicle endocytosis(GO:0048488) clathrin-mediated endocytosis(GO:0072583)
0.0 0.1 GO:0008614 pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 metabolic process(GO:0042816) vitamin B6 biosynthetic process(GO:0042819)
0.0 0.1 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.0 0.3 GO:0048008 platelet-derived growth factor receptor signaling pathway(GO:0048008)
0.0 0.1 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0 0.1 GO:0046504 ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
0.0 0.1 GO:0046426 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0 0.1 GO:0009200 deoxyribonucleoside triphosphate metabolic process(GO:0009200)
0.0 0.1 GO:0000052 citrulline metabolic process(GO:0000052)
0.0 0.1 GO:0007258 JUN phosphorylation(GO:0007258)
0.0 0.0 GO:0042711 maternal behavior(GO:0042711) parental behavior(GO:0060746)
0.0 0.1 GO:2001235 positive regulation of mitochondrion organization(GO:0010822) positive regulation of release of cytochrome c from mitochondria(GO:0090200) positive regulation of apoptotic signaling pathway(GO:2001235)
0.0 0.1 GO:0006663 platelet activating factor biosynthetic process(GO:0006663) platelet activating factor metabolic process(GO:0046469)
0.0 0.0 GO:0042253 granulocyte macrophage colony-stimulating factor biosynthetic process(GO:0042253)
0.0 0.1 GO:0009128 purine nucleoside monophosphate catabolic process(GO:0009128) ribonucleoside monophosphate catabolic process(GO:0009158) purine ribonucleoside monophosphate catabolic process(GO:0009169)
0.0 0.1 GO:0032455 nerve growth factor processing(GO:0032455)
0.0 0.0 GO:0061213 positive regulation of mesonephros development(GO:0061213) positive regulation of branching involved in ureteric bud morphogenesis(GO:0090190)
0.0 0.0 GO:0060839 endothelial cell fate commitment(GO:0060839)
0.0 0.0 GO:0060435 bronchiole development(GO:0060435)
0.0 0.0 GO:0043578 nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0 0.0 GO:0034616 response to laminar fluid shear stress(GO:0034616)
0.0 0.0 GO:0060872 semicircular canal development(GO:0060872)
0.0 0.2 GO:0007184 SMAD protein import into nucleus(GO:0007184)
0.0 0.0 GO:0033173 calcineurin-NFAT signaling cascade(GO:0033173)
0.0 0.2 GO:0007128 meiotic prophase I(GO:0007128)
0.0 0.1 GO:0050872 white fat cell differentiation(GO:0050872)
0.0 0.1 GO:0009261 ribonucleotide catabolic process(GO:0009261)
0.0 0.1 GO:0034446 substrate adhesion-dependent cell spreading(GO:0034446)
0.0 0.1 GO:0016266 O-glycan processing(GO:0016266)
0.0 0.1 GO:0009151 purine deoxyribonucleotide metabolic process(GO:0009151)
0.0 0.0 GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II(GO:0019886)
0.0 0.1 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.0 0.1 GO:1902001 fatty acid transmembrane transport(GO:1902001)
0.0 0.0 GO:0001778 plasma membrane repair(GO:0001778)
0.0 0.0 GO:0021591 ventricular system development(GO:0021591)
0.0 0.1 GO:0006927 obsolete transformed cell apoptotic process(GO:0006927)
0.0 0.0 GO:0032488 Cdc42 protein signal transduction(GO:0032488)
0.0 0.0 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
0.0 0.0 GO:0060061 Spemann organizer formation(GO:0060061)
0.0 0.1 GO:0006072 glycerol-3-phosphate metabolic process(GO:0006072)
0.0 0.1 GO:0048712 negative regulation of astrocyte differentiation(GO:0048712)
0.0 0.1 GO:0050917 sensory perception of umami taste(GO:0050917)
0.0 0.0 GO:0090025 regulation of monocyte chemotaxis(GO:0090025) positive regulation of monocyte chemotaxis(GO:0090026)
0.0 0.0 GO:0006419 alanyl-tRNA aminoacylation(GO:0006419)
0.0 0.0 GO:0042091 interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.0 0.1 GO:0010092 organ induction(GO:0001759) specification of organ identity(GO:0010092)
0.0 0.0 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.0 0.1 GO:0051307 resolution of meiotic recombination intermediates(GO:0000712) meiotic chromosome separation(GO:0051307)
0.0 0.0 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.0 0.1 GO:0060259 regulation of feeding behavior(GO:0060259)
0.0 0.0 GO:0043461 proton-transporting ATP synthase complex assembly(GO:0043461) proton-transporting ATP synthase complex biogenesis(GO:0070272)
0.0 0.0 GO:0042574 retinal metabolic process(GO:0042574)
0.0 0.0 GO:0042659 regulation of cell fate specification(GO:0042659)
0.0 0.0 GO:0051898 negative regulation of protein kinase B signaling(GO:0051898)
0.0 0.0 GO:0046839 phospholipid dephosphorylation(GO:0046839)
0.0 0.3 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.0 0.0 GO:0060037 pharyngeal system development(GO:0060037)
0.0 0.0 GO:0051014 actin filament severing(GO:0051014)
0.0 0.1 GO:0001516 prostaglandin biosynthetic process(GO:0001516) prostanoid biosynthetic process(GO:0046457)
0.0 0.0 GO:0046831 regulation of RNA export from nucleus(GO:0046831)
0.0 0.1 GO:0006572 tyrosine catabolic process(GO:0006572)
0.0 0.0 GO:0046952 ketone body catabolic process(GO:0046952)
0.0 0.0 GO:0006591 ornithine metabolic process(GO:0006591)
0.0 0.0 GO:1903020 positive regulation of glycoprotein biosynthetic process(GO:0010560) positive regulation of glycoprotein metabolic process(GO:1903020)
0.0 0.1 GO:0002040 sprouting angiogenesis(GO:0002040)
0.0 0.0 GO:0010886 positive regulation of cholesterol storage(GO:0010886)
0.0 0.0 GO:0014912 negative regulation of smooth muscle cell migration(GO:0014912)
0.0 0.0 GO:0048539 bone marrow development(GO:0048539)
0.0 0.0 GO:0018125 peptidyl-cysteine methylation(GO:0018125)
0.0 0.0 GO:0006106 fumarate metabolic process(GO:0006106)
0.0 0.0 GO:0007501 mesodermal cell fate specification(GO:0007501)
0.0 0.0 GO:0071462 cellular response to water stimulus(GO:0071462)
0.0 0.0 GO:0060612 adipose tissue development(GO:0060612)
0.0 0.0 GO:0070254 mucus secretion(GO:0070254)
0.0 0.0 GO:0007386 compartment pattern specification(GO:0007386)
0.0 0.0 GO:0033137 negative regulation of peptidyl-serine phosphorylation(GO:0033137)
0.0 0.0 GO:0008354 germ cell migration(GO:0008354)
0.0 0.0 GO:0046121 deoxyribonucleoside metabolic process(GO:0009120) deoxyribonucleoside catabolic process(GO:0046121)
0.0 0.1 GO:0015824 proline transport(GO:0015824)
0.0 0.2 GO:0008272 sulfate transport(GO:0008272)
0.0 0.1 GO:0009629 response to gravity(GO:0009629)
0.0 0.0 GO:0045628 regulation of T-helper 2 cell differentiation(GO:0045628)
0.0 0.1 GO:0010225 response to UV-C(GO:0010225)
0.0 0.0 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.0 0.2 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.0 0.1 GO:0006195 purine nucleotide catabolic process(GO:0006195)
0.0 0.0 GO:0032239 regulation of nucleobase-containing compound transport(GO:0032239)
0.0 0.1 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)
0.0 0.0 GO:0019255 glucose 1-phosphate metabolic process(GO:0019255)
0.0 0.1 GO:0032964 collagen biosynthetic process(GO:0032964)
0.0 0.1 GO:0006206 pyrimidine nucleobase metabolic process(GO:0006206)
0.0 0.0 GO:0010587 miRNA metabolic process(GO:0010586) miRNA catabolic process(GO:0010587)
0.0 0.1 GO:0042693 muscle cell fate commitment(GO:0042693)
0.0 0.0 GO:0006828 manganese ion transport(GO:0006828)
0.0 0.1 GO:0060216 definitive hemopoiesis(GO:0060216)
0.0 0.0 GO:0043129 surfactant homeostasis(GO:0043129) chemical homeostasis within a tissue(GO:0048875)
0.0 0.0 GO:0003032 detection of oxygen(GO:0003032)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0005899 insulin receptor complex(GO:0005899)
0.0 0.2 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.0 0.1 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.0 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 0.2 GO:0071437 invadopodium(GO:0071437)
0.0 0.3 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.2 GO:0098642 network-forming collagen trimer(GO:0098642) collagen network(GO:0098645)
0.0 0.1 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.0 0.2 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.1 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.1 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.3 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 0.1 GO:0033268 node of Ranvier(GO:0033268)
0.0 0.0 GO:0098651 basement membrane collagen trimer(GO:0098651)
0.0 0.1 GO:0043083 synaptic cleft(GO:0043083)
0.0 0.0 GO:0032809 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0 0.1 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.4 GO:0005811 lipid particle(GO:0005811)
0.0 0.1 GO:0016442 RISC complex(GO:0016442) RNAi effector complex(GO:0031332)
0.0 0.2 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.0 0.1 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.1 GO:0016012 sarcoglycan complex(GO:0016012)
0.0 0.1 GO:0036454 insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454)
0.0 0.2 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 0.1 GO:0031512 motile primary cilium(GO:0031512)
0.0 0.1 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.0 0.1 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 0.0 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0 0.1 GO:0031312 extrinsic component of organelle membrane(GO:0031312)
0.0 0.6 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 0.0 GO:0043230 extracellular organelle(GO:0043230)
0.0 0.1 GO:0005861 troponin complex(GO:0005861)
0.0 0.1 GO:0005639 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.0 0.0 GO:0030934 anchoring collagen complex(GO:0030934)
0.0 0.1 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 0.0 GO:0042272 nuclear RNA export factor complex(GO:0042272)
0.0 0.0 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.0 0.1 GO:0008091 spectrin(GO:0008091)
0.0 0.0 GO:0001520 outer dense fiber(GO:0001520) sperm flagellum(GO:0036126)
0.0 0.0 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.0 0.1 GO:0043034 costamere(GO:0043034)
0.0 0.1 GO:0008290 F-actin capping protein complex(GO:0008290)
0.0 0.1 GO:0031430 M band(GO:0031430)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.1 0.3 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.1 0.2 GO:0004117 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117)
0.1 0.2 GO:0050544 arachidonic acid binding(GO:0050544)
0.1 0.2 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.1 0.2 GO:0002162 dystroglycan binding(GO:0002162)
0.1 0.2 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.1 0.2 GO:0070052 collagen V binding(GO:0070052)
0.1 0.2 GO:0015204 urea transmembrane transporter activity(GO:0015204)
0.1 0.2 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.1 GO:0004948 calcitonin receptor activity(GO:0004948)
0.0 0.1 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.0 0.2 GO:0005010 insulin-like growth factor-activated receptor activity(GO:0005010)
0.0 0.2 GO:0004849 uridine kinase activity(GO:0004849)
0.0 0.1 GO:0042978 ornithine decarboxylase activator activity(GO:0042978)
0.0 0.2 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.0 0.2 GO:0004668 protein-arginine deiminase activity(GO:0004668)
0.0 0.1 GO:0033130 acetylcholine receptor binding(GO:0033130)
0.0 0.2 GO:0042805 actinin binding(GO:0042805)
0.0 0.1 GO:0017159 pantetheine hydrolase activity(GO:0017159)
0.0 0.2 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.0 0.4 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 0.0 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.0 0.2 GO:0048406 nerve growth factor binding(GO:0048406)
0.0 0.1 GO:0016901 oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor(GO:0016901)
0.0 0.2 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.0 0.0 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.0 0.1 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.0 0.1 GO:0016886 ligase activity, forming phosphoric ester bonds(GO:0016886)
0.0 0.1 GO:0050508 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.0 0.1 GO:0071553 uridine nucleotide receptor activity(GO:0015065) G-protein coupled pyrimidinergic nucleotide receptor activity(GO:0071553)
0.0 0.3 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0 0.1 GO:0030172 troponin C binding(GO:0030172)
0.0 0.2 GO:0017166 vinculin binding(GO:0017166)
0.0 0.1 GO:0035252 UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285)
0.0 0.1 GO:0070324 thyroid hormone binding(GO:0070324)
0.0 0.2 GO:0005110 frizzled-2 binding(GO:0005110)
0.0 0.1 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.0 0.1 GO:0008475 procollagen-lysine 5-dioxygenase activity(GO:0008475)
0.0 0.1 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.0 0.2 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.0 0.3 GO:0005523 tropomyosin binding(GO:0005523)
0.0 0.1 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0 0.2 GO:0070696 transmembrane receptor protein serine/threonine kinase binding(GO:0070696)
0.0 0.1 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.0 0.1 GO:0003953 NAD+ nucleosidase activity(GO:0003953)
0.0 0.1 GO:0008486 diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486)
0.0 0.1 GO:0005534 galactose binding(GO:0005534)
0.0 0.1 GO:0050265 RNA uridylyltransferase activity(GO:0050265)
0.0 0.3 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.0 0.1 GO:0070644 vitamin D response element binding(GO:0070644)
0.0 0.1 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.1 GO:0004470 malic enzyme activity(GO:0004470)
0.0 0.1 GO:0051637 obsolete Gram-positive bacterial cell surface binding(GO:0051637)
0.0 0.1 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.0 0.1 GO:0042808 obsolete neuronal Cdc2-like kinase binding(GO:0042808)
0.0 0.1 GO:0033765 steroid dehydrogenase activity, acting on the CH-CH group of donors(GO:0033765)
0.0 0.2 GO:0042171 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) lysophosphatidic acid acyltransferase activity(GO:0042171) lysophospholipid acyltransferase activity(GO:0071617)
0.0 0.1 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0 0.1 GO:0000293 ferric-chelate reductase activity(GO:0000293)
0.0 0.1 GO:0045545 syndecan binding(GO:0045545)
0.0 0.2 GO:0000339 RNA cap binding(GO:0000339)
0.0 0.1 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0 0.0 GO:0043559 insulin binding(GO:0043559)
0.0 0.1 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 0.1 GO:0031994 insulin-like growth factor I binding(GO:0031994)
0.0 0.1 GO:0052743 inositol tetrakisphosphate phosphatase activity(GO:0052743)
0.0 0.1 GO:0003680 AT DNA binding(GO:0003680)
0.0 0.1 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.0 0.0 GO:0070815 peptidyl-lysine 5-dioxygenase activity(GO:0070815)
0.0 0.1 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0 0.1 GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.0 0.1 GO:0004075 biotin carboxylase activity(GO:0004075)
0.0 0.1 GO:0004791 thioredoxin-disulfide reductase activity(GO:0004791)
0.0 0.0 GO:1901567 icosanoid binding(GO:0050542) fatty acid derivative binding(GO:1901567)
0.0 0.1 GO:0003987 acetate-CoA ligase activity(GO:0003987)
0.0 0.4 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 0.1 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0 0.1 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.0 0.8 GO:0008009 chemokine activity(GO:0008009)
0.0 0.0 GO:0004967 glucagon receptor activity(GO:0004967)
0.0 0.0 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.0 0.1 GO:0004300 enoyl-CoA hydratase activity(GO:0004300)
0.0 0.1 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.1 GO:0004597 peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.0 0.1 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.0 0.1 GO:0005042 netrin receptor activity(GO:0005042)
0.0 0.4 GO:0005158 insulin receptor binding(GO:0005158)
0.0 0.1 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0 0.0 GO:0004924 oncostatin-M receptor activity(GO:0004924)
0.0 0.0 GO:0004705 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0 0.2 GO:0008271 secondary active sulfate transmembrane transporter activity(GO:0008271)
0.0 0.1 GO:0004645 phosphorylase activity(GO:0004645)
0.0 0.2 GO:0070064 proline-rich region binding(GO:0070064)
0.0 0.1 GO:0051635 obsolete bacterial cell surface binding(GO:0051635)
0.0 0.0 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
0.0 0.0 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
0.0 0.0 GO:0034056 estrogen response element binding(GO:0034056)
0.0 0.0 GO:0004366 glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
0.0 0.0 GO:0004999 vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.0 0.2 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641)
0.0 0.0 GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.0 0.1 GO:0001595 angiotensin receptor activity(GO:0001595) angiotensin type II receptor activity(GO:0004945)
0.0 0.3 GO:0017046 peptide hormone binding(GO:0017046)
0.0 0.0 GO:0097493 extracellular matrix constituent conferring elasticity(GO:0030023) structural molecule activity conferring elasticity(GO:0097493)
0.0 0.0 GO:0019870 potassium channel inhibitor activity(GO:0019870)
0.0 0.1 GO:0045499 chemorepellent activity(GO:0045499)
0.0 0.1 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.0 0.2 GO:0030971 receptor tyrosine kinase binding(GO:0030971) protein tyrosine kinase binding(GO:1990782)
0.0 0.0 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.0 0.2 GO:0042301 phosphate ion binding(GO:0042301)
0.0 0.0 GO:0004813 alanine-tRNA ligase activity(GO:0004813)
0.0 0.1 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.0 0.1 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 0.1 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
0.0 0.2 GO:0070566 adenylyltransferase activity(GO:0070566)
0.0 0.1 GO:0008048 calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.0 0.0 GO:0000268 peroxisome targeting sequence binding(GO:0000268)
0.0 0.0 GO:0010485 H4 histone acetyltransferase activity(GO:0010485)
0.0 0.1 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 0.0 GO:0016635 oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor(GO:0016635)
0.0 0.1 GO:0047035 testosterone dehydrogenase (NAD+) activity(GO:0047035)
0.0 0.0 GO:0050998 nitric-oxide synthase binding(GO:0050998)
0.0 0.1 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0 0.1 GO:0004046 aminoacylase activity(GO:0004046)
0.0 0.1 GO:0016248 channel inhibitor activity(GO:0016248)
0.0 0.0 GO:0008061 chitin binding(GO:0008061)
0.0 0.1 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.0 0.0 GO:0050510 N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510)
0.0 0.1 GO:0017110 nucleoside-diphosphatase activity(GO:0017110)
0.0 0.1 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0 0.1 GO:0003796 lysozyme activity(GO:0003796)
0.0 0.0 GO:0008502 melatonin receptor activity(GO:0008502)
0.0 0.0 GO:0004815 aspartate-tRNA ligase activity(GO:0004815)
0.0 0.0 GO:0019215 intermediate filament binding(GO:0019215)
0.0 0.0 GO:0004167 dopachrome isomerase activity(GO:0004167)
0.0 0.0 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656) peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.0 0.2 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 0.0 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.0 0.0 GO:0004045 aminoacyl-tRNA hydrolase activity(GO:0004045)
0.0 0.1 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 0.1 GO:0000403 Y-form DNA binding(GO:0000403)
0.0 0.0 GO:0004346 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.0 0.1 GO:0051787 misfolded protein binding(GO:0051787)
0.0 0.1 GO:0004467 long-chain fatty acid-CoA ligase activity(GO:0004467)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.0 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 0.1 PID AMB2 NEUTROPHILS PATHWAY amb2 Integrin signaling
0.0 0.2 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.0 0.3 ST G ALPHA S PATHWAY G alpha s Pathway
0.0 0.7 NABA COLLAGENS Genes encoding collagen proteins
0.0 0.0 PID IFNG PATHWAY IFN-gamma pathway
0.0 0.1 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.0 0.1 ST INTEGRIN SIGNALING PATHWAY Integrin Signaling Pathway
0.0 0.3 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.0 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.0 0.0 ST GAQ PATHWAY G alpha q Pathway
0.0 0.2 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 0.1 PID NETRIN PATHWAY Netrin-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.1 REACTOME DAG AND IP3 SIGNALING Genes involved in DAG and IP3 signaling
0.0 0.4 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.9 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.0 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0 0.6 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 0.1 REACTOME SHC1 EVENTS IN EGFR SIGNALING Genes involved in SHC1 events in EGFR signaling
0.0 0.1 REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION Genes involved in activated TAK1 mediates p38 MAPK activation
0.0 0.1 REACTOME REGULATION OF KIT SIGNALING Genes involved in Regulation of KIT signaling
0.0 0.0 REACTOME G ALPHA Z SIGNALLING EVENTS Genes involved in G alpha (z) signalling events
0.0 0.2 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 0.4 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.0 0.5 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.2 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.0 0.0 REACTOME IL 3 5 AND GM CSF SIGNALING Genes involved in Interleukin-3, 5 and GM-CSF signaling
0.0 0.3 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 0.3 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 0.1 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.3 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 0.1 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 0.1 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.0 0.7 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.3 REACTOME ADP SIGNALLING THROUGH P2RY12 Genes involved in ADP signalling through P2Y purinoceptor 12
0.0 0.2 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.0 0.0 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 0.3 REACTOME AMINE COMPOUND SLC TRANSPORTERS Genes involved in Amine compound SLC transporters
0.0 0.1 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.0 0.4 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 0.0 REACTOME ARMS MEDIATED ACTIVATION Genes involved in ARMS-mediated activation
0.0 0.1 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 0.2 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.1 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling