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ENCODE: H3K4me1 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for NKX2-6

Z-value: 1.37

Motif logo

Transcription factors associated with NKX2-6

Gene Symbol	Gene ID	Gene Info
NKX2-6 Ensembl NCBI GeneCards UniProt	ENSG00000180053.6	NKX2-6

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
NKX2-6	chr8_23553705_23553856	10142	0.157480	0.53	1.4e-01	Click!
NKX2-6	chr8_23554046_23554197	9801	0.158195	0.49	1.8e-01	Click!
NKX2-6	chr8_23563753_23563904	94	0.925228	-0.42	2.6e-01	Click!
NKX2-6	chr8_23563478_23563629	369	0.766455	-0.41	2.7e-01	Click!
NKX2-6	chr8_23560501_23560652	3346	0.200322	-0.37	3.3e-01	Click!

Activity of the NKX2-6 motif across conditions

Conditions sorted by the z-value of the NKX2-6 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr9_16540961_16541659	0.62	RP11-183I6.2		68124	0.12
chr11_73990200_73990857	0.49	ENSG00000206913	.	26931	0.14
chr22_40830866_40831668	0.48	RP5-1042K10.13		20260	0.14
chr21_35918859_35919211	0.46	RCAN1	regulator of calcineurin 1	13442	0.2
chr3_45687605_45688015	0.44	LIMD1-AS1	LIMD1 antisense RNA 1	42564	0.12
chr15_71060497_71060707	0.43	UACA	uveal autoantigen with coiled-coil domains and ankyrin repeats	4670	0.23
chr2_37947734_37948100	0.39	CDC42EP3	CDC42 effector protein (Rho GTPase binding) 3	17694	0.27
chr1_77941867_77942099	0.38	AK5	adenylate kinase 5	55809	0.12
chr8_125192495_125192646	0.38	FER1L6-AS2	FER1L6 antisense RNA 2	8807	0.26
chr2_217354341_217354722	0.37	AC098820.4		2612	0.22
chr12_63122687_63123266	0.36	ENSG00000238475	.	78021	0.09
chr2_172388783_172388934	0.35	CYBRD1	cytochrome b reductase 1	9269	0.25
chr2_145263610_145263985	0.34	ZEB2	zinc finger E-box binding homeobox 2	11318	0.24
chr17_32574614_32574944	0.34	CCL2	chemokine (C-C motif) ligand 2	7525	0.13
chr20_17629504_17629678	0.33	RRBP1	ribosome binding protein 1	11561	0.2
chr1_86458784_86459076	0.33	ENSG00000201620	.	109449	0.07
chr14_100376642_100376793	0.33	EML1	echinoderm microtubule associated protein like 1	12147	0.2
chr3_38871334_38871622	0.33	RP11-134J21.1		6085	0.2
chr7_81396029_81396416	0.33	HGF	hepatocyte growth factor (hepapoietin A; scatter factor)	3065	0.4
chr8_134244229_134244380	0.33	WISP1-OT1	WISP1 overlapping transcript 1 (non-protein coding)	3005	0.31
chr20_9063656_9063954	0.33	PLCB4	phospholipase C, beta 4	14057	0.24
chr13_31294257_31294613	0.33	ALOX5AP	arachidonate 5-lipoxygenase-activating protein	15210	0.26
chr10_3856587_3856738	0.33	KLF6	Kruppel-like factor 6	29189	0.2
chr10_29130225_29130376	0.33	C10orf126	chromosome 10 open reading frame 126	5037	0.26
chr10_54412447_54412741	0.32	RP11-556E13.1		91729	0.09
chr16_78719280_78719578	0.32	RP11-264L1.3		151158	0.04
chr8_129054673_129054878	0.32	ENSG00000221176	.	6623	0.21
chr5_111115219_111115750	0.32	NREP	neuronal regeneration related protein	21569	0.21
chr9_86786252_86786403	0.32	RP11-380F14.2		106807	0.06
chr15_80271357_80271985	0.32	BCL2A1	BCL2-related protein A1	7883	0.2
chr14_71839341_71839562	0.32	ENSG00000207444	.	25603	0.19
chr6_143281120_143281272	0.31	HIVEP2	human immunodeficiency virus type I enhancer binding protein 2	14858	0.23
chr7_13959398_13959662	0.31	ETV1	ets variant 1	66536	0.14
chr1_225942912_225943116	0.31	ENSG00000223306	.	14037	0.14
chr15_99271535_99272053	0.31	IGF1R	insulin-like growth factor 1 receptor	20734	0.22
chr1_192988213_192988364	0.31	UCHL5	ubiquitin carboxyl-terminal hydrolase L5	4764	0.21
chr12_29752319_29752470	0.31	TMTC1	transmembrane and tetratricopeptide repeat containing 1	4763	0.31
chr17_9249524_9249871	0.31	RP11-85B7.4		63206	0.12
chr5_158126612_158126763	0.30	CTD-2363C16.1		283327	0.01
chr5_158448429_158448934	0.30	CTD-2363C16.2		35867	0.17
chr12_109042760_109042911	0.30	CORO1C	coronin, actin binding protein, 1C	3286	0.17
chr10_97047482_97047633	0.30	PDLIM1	PDZ and LIM domain 1	3224	0.31
chr3_45684381_45684734	0.30	LIMD1-AS1	LIMD1 antisense RNA 1	45817	0.11
chr8_96715315_96715466	0.30	ENSG00000223297	.	24247	0.26
chr12_2494439_2494710	0.30	CACNA1C-IT3	CACNA1C intronic transcript 3 (non-protein coding)	115632	0.06
chr12_88756954_88757105	0.30	ENSG00000199245	.	67190	0.14
chr2_192116508_192116659	0.30	MYO1B	myosin IB	5574	0.29
chr3_45589006_45589723	0.30	LARS2-AS1	LARS2 antisense RNA 1	38327	0.14
chr1_97004836_97004987	0.30	ENSG00000241992	.	43854	0.2
chr1_68187782_68188175	0.29	GADD45A	growth arrest and DNA-damage-inducible, alpha	37094	0.16
chr11_121961832_121961983	0.29	ENSG00000207971	.	8645	0.17
chr15_67065770_67066102	0.29	SMAD6	SMAD family member 6	61901	0.13
chr20_23132592_23133523	0.29	ENSG00000201527	.	8551	0.22
chr1_200337482_200337689	0.29	ZNF281	zinc finger protein 281	41535	0.21
chr1_178055842_178055993	0.29	RASAL2	RAS protein activator like 2	6947	0.32
chr7_76867154_76867700	0.29	AC073635.5		20013	0.2
chr2_55339476_55339889	0.29	RTN4	reticulon 4	75	0.97
chr8_122001527_122001678	0.29	ENSG00000252093	.	80026	0.11
chr17_47076838_47077332	0.29	IGF2BP1	insulin-like growth factor 2 mRNA binding protein 1	1977	0.17
chr16_67274601_67274968	0.29	SLC9A5	solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5	6034	0.08
chr8_105689851_105690002	0.28	ENSG00000263732	.	77477	0.1
chr10_77290347_77290581	0.28	ENSG00000207583	.	21752	0.23
chr13_27157989_27158140	0.28	WASF3	WAS protein family, member 3	26177	0.23
chr12_20543454_20543605	0.28	RP11-284H19.1		20333	0.23
chr6_52467732_52468424	0.28	TRAM2	translocation associated membrane protein 2	26365	0.19
chr1_219299907_219300058	0.28	LYPLAL1	lysophospholipase-like 1	47204	0.17
chr1_211775743_211775938	0.28	RP11-359E8.5		18773	0.16
chr7_17001293_17001444	0.28	AGR3	anterior gradient 3	79757	0.1
chr4_157895789_157896050	0.27	PDGFC	platelet derived growth factor C	3373	0.27
chr4_157416635_157416786	0.27	RP11-171N4.2	Uncharacterized protein	146749	0.04
chr1_61370549_61370700	0.27	NFIA	nuclear factor I/A	39693	0.19
chr20_40138790_40139006	0.27	CHD6	chromodomain helicase DNA binding protein 6	10941	0.28
chr13_30095383_30095797	0.27	MTUS2-AS1	MTUS2 antisense RNA 1	31348	0.21
chr1_17448827_17448978	0.27	PADI2	peptidyl arginine deiminase, type II	2954	0.25
chr6_133032333_133032512	0.27	VNN1	vanin 1	2766	0.21
chr4_14061132_14061426	0.27	ENSG00000252092	.	401028	0.01
chr4_88296347_88296610	0.27	ENSG00000240966	.	11848	0.15
chr17_53504679_53504830	0.27	MMD	monocyte to macrophage differentiation-associated	5401	0.32
chr3_67047069_67047341	0.27	KBTBD8	kelch repeat and BTB (POZ) domain containing 8	1522	0.59
chr11_2324783_2325431	0.27	TSPAN32	tetraspanin 32	1009	0.38
chr10_44958607_44958758	0.27	CXCL12	chemokine (C-X-C motif) ligand 12	78142	0.11
chr17_67139065_67139216	0.26	ABCA6	ATP-binding cassette, sub-family A (ABC1), member 6	1111	0.51
chr5_34524127_34524278	0.26	RAI14	retinoic acid induced 14	132140	0.05
chr4_157860965_157861230	0.26	PDGFC	platelet derived growth factor C	30958	0.19
chr15_40171438_40171589	0.26	GPR176	G protein-coupled receptor 176	40913	0.11
chr2_153469749_153469919	0.26	FMNL2	formin-like 2	6258	0.31
chr7_137557971_137558230	0.26	DGKI	diacylglycerol kinase, iota	26262	0.2
chr2_40354084_40354235	0.26	SLC8A1-AS1	SLC8A1 antisense RNA 1	11990	0.31
chr7_137628746_137628897	0.26	AC022173.2		9273	0.21
chr4_120439477_120439628	0.26	PDE5A	phosphodiesterase 5A, cGMP-specific	702	0.73
chr6_123032140_123032424	0.26	PKIB	protein kinase (cAMP-dependent, catalytic) inhibitor beta	6424	0.24
chr17_74711629_74712064	0.26	MXRA7	matrix-remodelling associated 7	4748	0.09
chr3_171283226_171283448	0.26	ENSG00000207114	.	61197	0.13
chr7_120633768_120634071	0.26	CPED1	cadherin-like and PC-esterase domain containing 1	4243	0.23
chr10_93871030_93871181	0.26	ENSG00000252993	.	35106	0.16
chr1_101093719_101093870	0.26	GPR88	G protein-coupled receptor 88	90101	0.08
chr1_21451523_21451771	0.26	EIF4G3	eukaryotic translation initiation factor 4 gamma, 3	35946	0.17
chr2_200603538_200603689	0.26	FTCDNL1	formiminotransferase cyclodeaminase N-terminal like	111983	0.07
chr5_33369882_33370033	0.26	CTD-2203K17.1		70768	0.12
chr5_138875477_138875767	0.26	TMEM173	transmembrane protein 173	13247	0.13
chr6_82472333_82472746	0.26	ENSG00000206886	.	1202	0.5
chr12_13270933_13271084	0.25	GSG1	germ cell associated 1	14389	0.21
chr12_93770029_93770180	0.25	RP11-486A14.2		1380	0.31
chr4_26143484_26143734	0.25	RBPJ	recombination signal binding protein for immunoglobulin kappa J region	21468	0.28
chr6_110417870_110418143	0.25	WASF1	WAS protein family, member 1	82846	0.09
chr15_71625454_71625605	0.25	RP11-592N21.2		9134	0.29
chr10_5504056_5504535	0.25	NET1	neuroepithelial cell transforming 1	15721	0.15
chr6_35185894_35186601	0.25	SCUBE3	signal peptide, CUB domain, EGF-like 3	4051	0.24
chr2_210337616_210337973	0.25	MAP2	microtubule-associated protein 2	49012	0.19
chr5_124820297_124820570	0.25	ENSG00000222107	.	133609	0.06
chr10_92681329_92681480	0.25	ANKRD1	ankyrin repeat domain 1 (cardiac muscle)	371	0.79
chr7_29905918_29906329	0.25	WIPF3	WAS/WASL interacting protein family, member 3	31782	0.17
chr10_31550924_31551075	0.25	ENSG00000252479	.	2471	0.35
chr7_114627811_114627962	0.25	MDFIC	MyoD family inhibitor domain containing	53962	0.18
chr1_29528780_29529144	0.25	SRSF4	serine/arginine-rich splicing factor 4	20463	0.13
chr1_235104740_235105149	0.25	ENSG00000239690	.	65011	0.12
chr11_121965409_121965560	0.25	ENSG00000207971	.	5068	0.18
chr4_186837108_186837259	0.25	ENSG00000239034	.	30054	0.18
chr7_41517588_41517820	0.25	INHBA-AS1	INHBA antisense RNA 1	215810	0.02
chr8_98983880_98984031	0.25	MATN2	matrilin 2	10245	0.2
chr2_218550468_218550619	0.25	DIRC3	disrupted in renal carcinoma 3	70735	0.12
chr15_51225693_51226195	0.25	AP4E1	adaptor-related protein complex 4, epsilon 1 subunit	24952	0.23
chr7_76855540_76855691	0.25	FGL2	fibrinogen-like 2	26472	0.18
chr10_91921633_91921784	0.25	ENSG00000222451	.	2009	0.5
chr7_80264399_80264550	0.25	CD36	CD36 molecule (thrombospondin receptor)	3486	0.37
chr6_131428128_131428279	0.25	AKAP7	A kinase (PRKA) anchor protein 7	28603	0.22
chr2_183283239_183283390	0.25	PDE1A	phosphodiesterase 1A, calmodulin-dependent	8435	0.3
chr8_59966515_59966743	0.25	RP11-328K2.1		61132	0.11
chr12_104518100_104518251	0.25	ENSG00000199415	.	839	0.6
chr2_43303903_43304168	0.25	ENSG00000207087	.	14597	0.28
chr2_226982606_226982904	0.25	ENSG00000263363	.	540754	0.0
chr2_26661594_26661750	0.25	DRC1	dynein regulatory complex subunit 1 homolog (Chlamydomonas)	8315	0.21
chr10_3902800_3902951	0.25	KLF6	Kruppel-like factor 6	75402	0.11
chr20_2839933_2840363	0.24	VPS16	vacuolar protein sorting 16 homolog (S. cerevisiae)	2955	0.18
chr8_104117881_104118032	0.24	ENSG00000265667	.	13007	0.13
chr5_114915172_114915323	0.24	AC010226.4		22507	0.14
chr7_33948512_33948663	0.24	BMPER	BMP binding endothelial regulator	3442	0.38
chr17_30070933_30071094	0.24	ENSG00000202026	.	30241	0.18
chr17_36586871_36587022	0.24	ARHGAP23	Rho GTPase activating protein 23	2216	0.26
chr1_10441222_10441373	0.24	ENSG00000265945	.	8762	0.13
chr4_169652420_169652571	0.24	PALLD	palladin, cytoskeletal associated protein	19185	0.21
chr8_108314695_108314915	0.24	ANGPT1	angiopoietin 1	33945	0.21
chr2_144711401_144711552	0.24	AC016910.1		16836	0.25
chr7_48285699_48285984	0.24	ABCA13	ATP-binding cassette, sub-family A (ABC1), member 13	74784	0.12
chr5_125351586_125351737	0.24	ENSG00000265637	.	180867	0.03
chr18_455946_456097	0.24	RP11-720L2.2		31605	0.16
chr6_82454549_82454764	0.24	FAM46A	family with sequence similarity 46, member A	6814	0.2
chr6_127514210_127514472	0.24	RNF146	ring finger protein 146	73414	0.11
chr7_134574979_134575413	0.24	CALD1	caldesmon 1	955	0.69
chr18_46238546_46238697	0.24	RP11-426J5.2		23831	0.21
chr9_110399429_110399916	0.24	ENSG00000202308	.	25855	0.23
chr12_20061614_20061845	0.24	ENSG00000221679	.	64070	0.15
chr17_29894018_29894169	0.24	ENSG00000221038	.	3180	0.14
chr13_50783531_50783810	0.24	DLEU1	deleted in lymphocytic leukemia 1 (non-protein coding)	127363	0.05
chr11_34367020_34367283	0.24	ABTB2	ankyrin repeat and BTB (POZ) domain containing 2	11651	0.26
chr1_56162477_56162628	0.24	ENSG00000272051	.	211907	0.02
chr11_122556790_122557092	0.24	UBASH3B	ubiquitin associated and SH3 domain containing B	30558	0.18
chr2_69464357_69464627	0.24	ENSG00000199460	.	54483	0.12
chr1_180000870_180001021	0.24	CEP350	centrosomal protein 350kDa	9393	0.26
chr7_41518329_41518480	0.24	INHBA-AS1	INHBA antisense RNA 1	215110	0.02
chr4_16780959_16781110	0.24	LDB2	LIM domain binding 2	105098	0.08
chr7_100016771_100016922	0.24	ZCWPW1	zinc finger, CW type with PWWP domain 1	654	0.47
chr12_109117281_109117726	0.24	CORO1C	coronin, actin binding protein, 1C	6824	0.16
chr3_99681966_99682117	0.24	ENSG00000264897	.	1201	0.6
chr3_45100675_45100826	0.24	ENSG00000252410	.	24670	0.16
chr18_18744847_18745057	0.24	ENSG00000251886	.	44485	0.15
chr3_123509920_123510071	0.24	MYLK	myosin light chain kinase	2693	0.3
chr3_177649836_177649987	0.23	ENSG00000199858	.	75656	0.13
chr8_104241607_104241758	0.23	RP11-318M2.3		140	0.96
chr12_127768981_127769132	0.23	ENSG00000253089	.	36844	0.23
chr12_66455744_66455895	0.23	ENSG00000251857	.	4182	0.25
chr8_23381826_23381979	0.23	SLC25A37	solute carrier family 25 (mitochondrial iron transporter), member 37	4416	0.2
chr6_116733337_116733739	0.23	DSE	dermatan sulfate epimerase	41428	0.1
chr11_12841613_12841764	0.23	RP11-47J17.3		3526	0.26
chr10_3591240_3591463	0.23	RP11-184A2.3		201908	0.03
chr1_109936676_109936954	0.23	SORT1	sortilin 1	836	0.57
chr4_106117299_106117679	0.23	TET2-AS1	TET2 antisense RNA 1	18269	0.22
chr3_179435405_179435556	0.23	USP13	ubiquitin specific peptidase 13 (isopeptidase T-3)	3872	0.28
chr10_99478408_99478800	0.23	MARVELD1	MARVEL domain containing 1	5123	0.17
chr6_11522959_11523110	0.23	TMEM170B	transmembrane protein 170B	14904	0.22
chr9_129135479_129135756	0.23	MVB12B	multivesicular body subunit 12B	3105	0.29
chr12_27701552_27701930	0.23	PPFIBP1	PTPRF interacting protein, binding protein 1 (liprin beta 1)	10685	0.23
chr14_30392743_30392894	0.23	PRKD1	protein kinase D1	4030	0.28
chr16_57142254_57142881	0.23	CPNE2	copine II	1896	0.27
chrX_18979389_18979540	0.23	PHKA2	phosphorylase kinase, alpha 2 (liver)	23252	0.19
chr13_27540158_27540309	0.23	USP12-AS1	USP12 antisense RNA 1	196759	0.02
chr12_66050364_66050557	0.23	HMGA2	high mobility group AT-hook 2	167451	0.03
chr11_67781235_67781527	0.23	ALDH3B1	aldehyde dehydrogenase 3 family, member B1	3591	0.13
chr6_113396081_113396232	0.23	ENSG00000201386	.	103461	0.08
chr7_34078618_34078769	0.23	BMPER	BMP binding endothelial regulator	133548	0.05
chr6_132455519_132455670	0.23	ENSG00000265669	.	19191	0.27
chr1_25119704_25119971	0.23	ENSG00000238482	.	15367	0.21
chr4_141031157_141031308	0.23	RP11-392B6.1		17937	0.23
chr13_60265756_60265907	0.23	ENSG00000239003	.	211627	0.02
chr1_178599347_178599498	0.23	ENSG00000266417	.	47462	0.12
chr10_31888840_31889209	0.23	ENSG00000222412	.	156040	0.04
chr3_12750431_12750810	0.23	TMEM40	transmembrane protein 40	33396	0.14
chr3_30204653_30204804	0.23	ENSG00000266546	.	24204	0.21
chr4_74698717_74699078	0.23	CXCL6	chemokine (C-X-C motif) ligand 6	3317	0.2
chr3_113345260_113345597	0.23	ENSG00000241529	.	6123	0.18

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX2-6

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.7	GO:0007171	activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.1	0.3	GO:0021801	cerebral cortex radial glia guided migration(GO:0021801) telencephalon glial cell migration(GO:0022030)
0.1	0.1	GO:0060028	convergent extension involved in axis elongation(GO:0060028)
0.1	0.2	GO:0060831	smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:0060831)
0.1	0.3	GO:0048149	behavioral response to ethanol(GO:0048149)
0.1	0.3	GO:0060665	regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.1	0.2	GO:0070874	negative regulation of glycogen metabolic process(GO:0070874)
0.1	0.2	GO:0070050	neuron cellular homeostasis(GO:0070050)
0.1	0.2	GO:0000103	sulfate assimilation(GO:0000103)
0.1	0.2	GO:0001996	positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996)
0.1	0.2	GO:0030091	protein repair(GO:0030091)
0.1	0.3	GO:0032277	negative regulation of gonadotropin secretion(GO:0032277)
0.1	0.2	GO:0071277	cellular response to calcium ion(GO:0071277)
0.1	0.2	GO:0007221	positive regulation of transcription of Notch receptor target(GO:0007221)
0.1	0.2	GO:1900115	sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.1	0.1	GO:0048245	eosinophil chemotaxis(GO:0048245) eosinophil migration(GO:0072677)
0.1	0.1	GO:0060449	bud elongation involved in lung branching(GO:0060449)
0.1	0.2	GO:0055098	response to low-density lipoprotein particle(GO:0055098)
0.1	0.3	GO:0006910	phagocytosis, recognition(GO:0006910)
0.1	0.2	GO:0043589	skin morphogenesis(GO:0043589)
0.1	0.1	GO:0060648	mammary gland bud morphogenesis(GO:0060648)
0.0	0.3	GO:0070098	chemokine-mediated signaling pathway(GO:0070098)
0.0	0.1	GO:0010842	retina layer formation(GO:0010842)
0.0	0.0	GO:0043117	positive regulation of vascular permeability(GO:0043117)
0.0	0.2	GO:0045662	negative regulation of myoblast differentiation(GO:0045662)
0.0	0.2	GO:0051497	negative regulation of stress fiber assembly(GO:0051497)
0.0	0.1	GO:0006065	UDP-glucuronate biosynthetic process(GO:0006065)
0.0	0.1	GO:0048669	collateral sprouting in absence of injury(GO:0048669)
0.0	0.1	GO:0030538	embryonic genitalia morphogenesis(GO:0030538)
0.0	0.2	GO:0018101	protein citrullination(GO:0018101)
0.0	0.1	GO:0002043	blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.0	0.0	GO:0060242	contact inhibition(GO:0060242)
0.0	0.2	GO:0097061	dendritic spine morphogenesis(GO:0060997) regulation of dendritic spine morphogenesis(GO:0061001) dendritic spine organization(GO:0097061)
0.0	0.2	GO:0071731	response to nitric oxide(GO:0071731)
0.0	0.2	GO:0060753	mast cell chemotaxis(GO:0002551) regulation of mast cell chemotaxis(GO:0060753) positive regulation of mast cell chemotaxis(GO:0060754) mast cell migration(GO:0097531)
0.0	0.3	GO:0045652	regulation of megakaryocyte differentiation(GO:0045652) regulation of hematopoietic progenitor cell differentiation(GO:1901532)
0.0	0.1	GO:0060638	mesenchymal-epithelial cell signaling(GO:0060638)
0.0	0.1	GO:0048702	embryonic neurocranium morphogenesis(GO:0048702)
0.0	0.1	GO:0035234	ectopic germ cell programmed cell death(GO:0035234)
0.0	0.2	GO:0007185	transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0	0.1	GO:0045343	MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343)
0.0	0.1	GO:0055089	fatty acid homeostasis(GO:0055089)
0.0	0.2	GO:0060180	regulation of female receptivity(GO:0045924) female mating behavior(GO:0060180)
0.0	0.2	GO:0001547	antral ovarian follicle growth(GO:0001547)
0.0	0.1	GO:0010766	negative regulation of sodium ion transport(GO:0010766)
0.0	0.1	GO:0072311	renal filtration cell differentiation(GO:0061318) glomerular epithelium development(GO:0072010) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.0	0.1	GO:0032926	negative regulation of activin receptor signaling pathway(GO:0032926)
0.0	0.2	GO:0033327	Leydig cell differentiation(GO:0033327)
0.0	0.1	GO:0045425	positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process(GO:0045425)
0.0	0.1	GO:0006654	phosphatidic acid biosynthetic process(GO:0006654)
0.0	0.1	GO:0006651	diacylglycerol biosynthetic process(GO:0006651)
0.0	0.1	GO:0032509	endosome transport via multivesicular body sorting pathway(GO:0032509)
0.0	0.1	GO:1903053	regulation of extracellular matrix disassembly(GO:0010715) negative regulation of extracellular matrix disassembly(GO:0010716) regulation of extracellular matrix organization(GO:1903053) negative regulation of extracellular matrix organization(GO:1903054)
0.0	0.0	GO:0042661	regulation of mesodermal cell fate specification(GO:0042661) regulation of mesoderm development(GO:2000380)
0.0	0.1	GO:0048312	intracellular distribution of mitochondria(GO:0048312)
0.0	0.1	GO:0016102	retinoic acid biosynthetic process(GO:0002138) diterpenoid biosynthetic process(GO:0016102)
0.0	0.1	GO:0051305	chromosome movement towards spindle pole(GO:0051305)
0.0	0.2	GO:0031017	exocrine pancreas development(GO:0031017)
0.0	0.1	GO:0034393	positive regulation of muscle cell apoptotic process(GO:0010661) positive regulation of smooth muscle cell apoptotic process(GO:0034393)
0.0	0.2	GO:0032462	regulation of protein homooligomerization(GO:0032462)
0.0	0.1	GO:0017121	phospholipid scrambling(GO:0017121)
0.0	0.1	GO:0033962	cytoplasmic mRNA processing body assembly(GO:0033962)
0.0	0.1	GO:0007406	negative regulation of neuroblast proliferation(GO:0007406) negative regulation of neural precursor cell proliferation(GO:2000178)
0.0	0.1	GO:0032344	regulation of ketone biosynthetic process(GO:0010566) regulation of aldosterone metabolic process(GO:0032344) regulation of aldosterone biosynthetic process(GO:0032347)
0.0	0.1	GO:0007028	cytoplasm organization(GO:0007028)
0.0	0.2	GO:0015840	urea transport(GO:0015840)
0.0	0.0	GO:0060197	cloaca development(GO:0035844) cloacal septation(GO:0060197)
0.0	0.1	GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.0	0.1	GO:2000095	regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000095)
0.0	0.2	GO:0070875	positive regulation of glycogen biosynthetic process(GO:0045725) positive regulation of glycogen metabolic process(GO:0070875)
0.0	0.1	GO:0016322	neuron remodeling(GO:0016322)
0.0	0.1	GO:0008300	isoprenoid catabolic process(GO:0008300)
0.0	0.1	GO:0010815	bradykinin catabolic process(GO:0010815)
0.0	0.1	GO:0070561	vitamin D receptor signaling pathway(GO:0070561)
0.0	0.0	GO:0060083	smooth muscle contraction involved in micturition(GO:0060083)
0.0	0.1	GO:0018242	protein O-linked glycosylation via serine(GO:0018242) protein O-linked glycosylation via threonine(GO:0018243)
0.0	0.1	GO:0015911	plasma membrane long-chain fatty acid transport(GO:0015911)
0.0	0.1	GO:0060129	thyroid-stimulating hormone-secreting cell differentiation(GO:0060129)
0.0	0.1	GO:0050774	negative regulation of dendrite morphogenesis(GO:0050774)
0.0	0.2	GO:0043097	pyrimidine-containing compound salvage(GO:0008655) pyrimidine nucleoside salvage(GO:0043097)
0.0	0.1	GO:0014012	peripheral nervous system axon regeneration(GO:0014012)
0.0	0.2	GO:0015871	choline transport(GO:0015871)
0.0	0.1	GO:0006048	UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.0	0.0	GO:0003321	positive regulation of blood pressure by epinephrine-norepinephrine(GO:0003321)
0.0	0.1	GO:0045715	negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715)
0.0	0.0	GO:0001992	regulation of systemic arterial blood pressure by vasopressin(GO:0001992)
0.0	0.1	GO:0048630	skeletal muscle tissue growth(GO:0048630)
0.0	0.1	GO:0034638	phosphatidylcholine catabolic process(GO:0034638)
0.0	0.1	GO:0045992	negative regulation of embryonic development(GO:0045992)
0.0	0.1	GO:0060841	venous blood vessel development(GO:0060841)
0.0	0.0	GO:0021670	lateral ventricle development(GO:0021670)
0.0	0.1	GO:0008228	opsonization(GO:0008228)
0.0	0.0	GO:0001543	ovarian follicle rupture(GO:0001543)
0.0	0.0	GO:0060433	bronchus development(GO:0060433)
0.0	0.1	GO:0010193	response to ozone(GO:0010193)
0.0	0.1	GO:0008215	spermine metabolic process(GO:0008215)
0.0	0.0	GO:0002689	negative regulation of leukocyte chemotaxis(GO:0002689)
0.0	0.0	GO:0002887	negative regulation of myeloid leukocyte mediated immunity(GO:0002887) negative regulation of leukocyte degranulation(GO:0043301)
0.0	0.0	GO:0040019	positive regulation of embryonic development(GO:0040019)
0.0	0.0	GO:0010936	negative regulation of macrophage cytokine production(GO:0010936)
0.0	0.0	GO:0070141	response to UV-A(GO:0070141)
0.0	0.1	GO:0051124	synaptic growth at neuromuscular junction(GO:0051124)
0.0	0.1	GO:0033008	positive regulation of mast cell activation involved in immune response(GO:0033008) positive regulation of leukocyte degranulation(GO:0043302) positive regulation of mast cell degranulation(GO:0043306)
0.0	0.1	GO:0045793	positive regulation of cell size(GO:0045793)
0.0	0.1	GO:0022601	menstrual cycle phase(GO:0022601)
0.0	0.1	GO:0031641	regulation of myelination(GO:0031641)
0.0	0.1	GO:0019800	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0	0.1	GO:0007343	egg activation(GO:0007343)
0.0	0.3	GO:0021846	cell proliferation in forebrain(GO:0021846)
0.0	0.0	GO:0048680	positive regulation of axon regeneration(GO:0048680) positive regulation of neuron projection regeneration(GO:0070572)
0.0	0.1	GO:0071360	cellular response to exogenous dsRNA(GO:0071360)
0.0	0.0	GO:0045721	negative regulation of gluconeogenesis(GO:0045721)
0.0	0.0	GO:0033860	regulation of NAD(P)H oxidase activity(GO:0033860)
0.0	0.2	GO:0048844	artery morphogenesis(GO:0048844)
0.0	0.1	GO:0090073	positive regulation of protein homodimerization activity(GO:0090073)
0.0	0.1	GO:0036465	synaptic vesicle recycling(GO:0036465) synaptic vesicle endocytosis(GO:0048488) clathrin-mediated endocytosis(GO:0072583)
0.0	0.1	GO:0008614	pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 metabolic process(GO:0042816) vitamin B6 biosynthetic process(GO:0042819)
0.0	0.1	GO:0046856	phosphatidylinositol dephosphorylation(GO:0046856)
0.0	0.3	GO:0048008	platelet-derived growth factor receptor signaling pathway(GO:0048008)
0.0	0.1	GO:0030579	ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0	0.1	GO:0046504	ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
0.0	0.1	GO:0046426	negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0	0.1	GO:0009200	deoxyribonucleoside triphosphate metabolic process(GO:0009200)
0.0	0.1	GO:0000052	citrulline metabolic process(GO:0000052)
0.0	0.1	GO:0007258	JUN phosphorylation(GO:0007258)
0.0	0.0	GO:0042711	maternal behavior(GO:0042711) parental behavior(GO:0060746)
0.0	0.1	GO:2001235	positive regulation of mitochondrion organization(GO:0010822) positive regulation of release of cytochrome c from mitochondria(GO:0090200) positive regulation of apoptotic signaling pathway(GO:2001235)
0.0	0.1	GO:0006663	platelet activating factor biosynthetic process(GO:0006663) platelet activating factor metabolic process(GO:0046469)
0.0	0.0	GO:0042253	granulocyte macrophage colony-stimulating factor biosynthetic process(GO:0042253)
0.0	0.1	GO:0009128	purine nucleoside monophosphate catabolic process(GO:0009128) ribonucleoside monophosphate catabolic process(GO:0009158) purine ribonucleoside monophosphate catabolic process(GO:0009169)
0.0	0.1	GO:0032455	nerve growth factor processing(GO:0032455)
0.0	0.0	GO:0061213	positive regulation of mesonephros development(GO:0061213) positive regulation of branching involved in ureteric bud morphogenesis(GO:0090190)
0.0	0.0	GO:0060839	endothelial cell fate commitment(GO:0060839)
0.0	0.0	GO:0060435	bronchiole development(GO:0060435)
0.0	0.0	GO:0043578	nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0	0.0	GO:0034616	response to laminar fluid shear stress(GO:0034616)
0.0	0.0	GO:0060872	semicircular canal development(GO:0060872)
0.0	0.2	GO:0007184	SMAD protein import into nucleus(GO:0007184)
0.0	0.0	GO:0033173	calcineurin-NFAT signaling cascade(GO:0033173)
0.0	0.2	GO:0007128	meiotic prophase I(GO:0007128)
0.0	0.1	GO:0050872	white fat cell differentiation(GO:0050872)
0.0	0.1	GO:0009261	ribonucleotide catabolic process(GO:0009261)
0.0	0.1	GO:0034446	substrate adhesion-dependent cell spreading(GO:0034446)
0.0	0.1	GO:0016266	O-glycan processing(GO:0016266)
0.0	0.1	GO:0009151	purine deoxyribonucleotide metabolic process(GO:0009151)
0.0	0.0	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II(GO:0019886)
0.0	0.1	GO:0032020	ISG15-protein conjugation(GO:0032020)
0.0	0.1	GO:1902001	fatty acid transmembrane transport(GO:1902001)
0.0	0.0	GO:0001778	plasma membrane repair(GO:0001778)
0.0	0.0	GO:0021591	ventricular system development(GO:0021591)
0.0	0.1	GO:0006927	obsolete transformed cell apoptotic process(GO:0006927)
0.0	0.0	GO:0032488	Cdc42 protein signal transduction(GO:0032488)
0.0	0.0	GO:0035426	extracellular matrix-cell signaling(GO:0035426)
0.0	0.0	GO:0060061	Spemann organizer formation(GO:0060061)
0.0	0.1	GO:0006072	glycerol-3-phosphate metabolic process(GO:0006072)
0.0	0.1	GO:0048712	negative regulation of astrocyte differentiation(GO:0048712)
0.0	0.1	GO:0050917	sensory perception of umami taste(GO:0050917)
0.0	0.0	GO:0090025	regulation of monocyte chemotaxis(GO:0090025) positive regulation of monocyte chemotaxis(GO:0090026)
0.0	0.0	GO:0006419	alanyl-tRNA aminoacylation(GO:0006419)
0.0	0.0	GO:0042091	interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.0	0.1	GO:0010092	organ induction(GO:0001759) specification of organ identity(GO:0010092)
0.0	0.0	GO:0032780	negative regulation of ATPase activity(GO:0032780)
0.0	0.1	GO:0051307	resolution of meiotic recombination intermediates(GO:0000712) meiotic chromosome separation(GO:0051307)
0.0	0.0	GO:0043490	malate-aspartate shuttle(GO:0043490)
0.0	0.1	GO:0060259	regulation of feeding behavior(GO:0060259)
0.0	0.0	GO:0043461	proton-transporting ATP synthase complex assembly(GO:0043461) proton-transporting ATP synthase complex biogenesis(GO:0070272)
0.0	0.0	GO:0042574	retinal metabolic process(GO:0042574)
0.0	0.0	GO:0042659	regulation of cell fate specification(GO:0042659)
0.0	0.0	GO:0051898	negative regulation of protein kinase B signaling(GO:0051898)
0.0	0.0	GO:0046839	phospholipid dephosphorylation(GO:0046839)
0.0	0.3	GO:0010811	positive regulation of cell-substrate adhesion(GO:0010811)
0.0	0.0	GO:0060037	pharyngeal system development(GO:0060037)
0.0	0.0	GO:0051014	actin filament severing(GO:0051014)
0.0	0.1	GO:0001516	prostaglandin biosynthetic process(GO:0001516) prostanoid biosynthetic process(GO:0046457)
0.0	0.0	GO:0046831	regulation of RNA export from nucleus(GO:0046831)
0.0	0.1	GO:0006572	tyrosine catabolic process(GO:0006572)
0.0	0.0	GO:0046952	ketone body catabolic process(GO:0046952)
0.0	0.0	GO:0006591	ornithine metabolic process(GO:0006591)
0.0	0.0	GO:1903020	positive regulation of glycoprotein biosynthetic process(GO:0010560) positive regulation of glycoprotein metabolic process(GO:1903020)
0.0	0.1	GO:0002040	sprouting angiogenesis(GO:0002040)
0.0	0.0	GO:0010886	positive regulation of cholesterol storage(GO:0010886)
0.0	0.0	GO:0014912	negative regulation of smooth muscle cell migration(GO:0014912)
0.0	0.0	GO:0048539	bone marrow development(GO:0048539)
0.0	0.0	GO:0018125	peptidyl-cysteine methylation(GO:0018125)
0.0	0.0	GO:0006106	fumarate metabolic process(GO:0006106)
0.0	0.0	GO:0007501	mesodermal cell fate specification(GO:0007501)
0.0	0.0	GO:0071462	cellular response to water stimulus(GO:0071462)
0.0	0.0	GO:0060612	adipose tissue development(GO:0060612)
0.0	0.0	GO:0070254	mucus secretion(GO:0070254)
0.0	0.0	GO:0007386	compartment pattern specification(GO:0007386)
0.0	0.0	GO:0033137	negative regulation of peptidyl-serine phosphorylation(GO:0033137)
0.0	0.0	GO:0008354	germ cell migration(GO:0008354)
0.0	0.0	GO:0046121	deoxyribonucleoside metabolic process(GO:0009120) deoxyribonucleoside catabolic process(GO:0046121)
0.0	0.1	GO:0015824	proline transport(GO:0015824)
0.0	0.2	GO:0008272	sulfate transport(GO:0008272)
0.0	0.1	GO:0009629	response to gravity(GO:0009629)
0.0	0.0	GO:0045628	regulation of T-helper 2 cell differentiation(GO:0045628)
0.0	0.1	GO:0010225	response to UV-C(GO:0010225)
0.0	0.0	GO:0045162	clustering of voltage-gated sodium channels(GO:0045162)
0.0	0.2	GO:0016998	cell wall macromolecule catabolic process(GO:0016998)
0.0	0.1	GO:0006195	purine nucleotide catabolic process(GO:0006195)
0.0	0.0	GO:0032239	regulation of nucleobase-containing compound transport(GO:0032239)
0.0	0.1	GO:0045600	positive regulation of fat cell differentiation(GO:0045600)
0.0	0.0	GO:0019255	glucose 1-phosphate metabolic process(GO:0019255)
0.0	0.1	GO:0032964	collagen biosynthetic process(GO:0032964)
0.0	0.1	GO:0006206	pyrimidine nucleobase metabolic process(GO:0006206)
0.0	0.0	GO:0010587	miRNA metabolic process(GO:0010586) miRNA catabolic process(GO:0010587)
0.0	0.1	GO:0042693	muscle cell fate commitment(GO:0042693)
0.0	0.0	GO:0006828	manganese ion transport(GO:0006828)
0.0	0.1	GO:0060216	definitive hemopoiesis(GO:0060216)
0.0	0.0	GO:0043129	surfactant homeostasis(GO:0043129) chemical homeostasis within a tissue(GO:0048875)
0.0	0.0	GO:0003032	detection of oxygen(GO:0003032)

Gene overrepresentation in cellular component category:

Total log-likelihood	Term	Description
0.1	GO:0005899	insulin receptor complex(GO:0005899)
0.2	GO:0005862	muscle thin filament tropomyosin(GO:0005862)
0.1	GO:0032045	guanyl-nucleotide exchange factor complex(GO:0032045)
0.0	GO:0031235	intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.2	GO:0071437	invadopodium(GO:0071437)
0.3	GO:0005614	interstitial matrix(GO:0005614)
0.2	GO:0098642	network-forming collagen trimer(GO:0098642) collagen network(GO:0098645)
0.1	GO:0009331	glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.2	GO:0017146	NMDA selective glutamate receptor complex(GO:0017146)
0.1	GO:0016327	apicolateral plasma membrane(GO:0016327)
0.1	GO:0030056	hemidesmosome(GO:0030056)
0.3	GO:0098643	fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1	GO:0033268	node of Ranvier(GO:0033268)
0.0	GO:0098651	basement membrane collagen trimer(GO:0098651)
0.1	GO:0043083	synaptic cleft(GO:0043083)
0.0	GO:0032809	neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.1	GO:0031092	platelet alpha granule membrane(GO:0031092)
0.4	GO:0005811	lipid particle(GO:0005811)
0.1	GO:0016442	RISC complex(GO:0016442) RNAi effector complex(GO:0031332)
0.2	GO:0034366	spherical high-density lipoprotein particle(GO:0034366)
0.1	GO:0005577	fibrinogen complex(GO:0005577)
0.1	GO:0016012	sarcoglycan complex(GO:0016012)
0.1	GO:0036454	insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454)
0.2	GO:0016281	eukaryotic translation initiation factor 4F complex(GO:0016281)
0.1	GO:0031512	motile primary cilium(GO:0031512)
0.1	GO:0031095	platelet dense tubular network membrane(GO:0031095)
0.1	GO:0046581	intercellular canaliculus(GO:0046581)
0.0	GO:0005589	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.1	GO:0031312	extrinsic component of organelle membrane(GO:0031312)
0.6	GO:0031093	platelet alpha granule lumen(GO:0031093)
0.0	GO:0043230	extracellular organelle(GO:0043230)
0.1	GO:0005861	troponin complex(GO:0005861)
0.1	GO:0005639	integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.0	GO:0030934	anchoring collagen complex(GO:0030934)
0.1	GO:0031362	anchored component of external side of plasma membrane(GO:0031362)
0.0	GO:0042272	nuclear RNA export factor complex(GO:0042272)
0.0	GO:0043625	delta DNA polymerase complex(GO:0043625)
0.1	GO:0008091	spectrin(GO:0008091)
0.0	GO:0001520	outer dense fiber(GO:0001520) sperm flagellum(GO:0036126)
0.0	GO:0030688	preribosome, small subunit precursor(GO:0030688)
0.1	GO:0043034	costamere(GO:0043034)
0.1	GO:0008290	F-actin capping protein complex(GO:0008290)
0.1	GO:0031430	M band(GO:0031430)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0051371	muscle alpha-actinin binding(GO:0051371)
0.1	0.3	GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.1	0.2	GO:0004117	calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117)
0.1	0.2	GO:0050544	arachidonic acid binding(GO:0050544)
0.1	0.2	GO:0004687	myosin light chain kinase activity(GO:0004687)
0.1	0.2	GO:0002162	dystroglycan binding(GO:0002162)
0.1	0.2	GO:0030297	transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.1	0.2	GO:0070052	collagen V binding(GO:0070052)
0.1	0.2	GO:0015204	urea transmembrane transporter activity(GO:0015204)
0.1	0.2	GO:0017112	Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0	0.1	GO:0004948	calcitonin receptor activity(GO:0004948)
0.0	0.1	GO:0033743	peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.0	0.2	GO:0005010	insulin-like growth factor-activated receptor activity(GO:0005010)
0.0	0.2	GO:0004849	uridine kinase activity(GO:0004849)
0.0	0.1	GO:0042978	ornithine decarboxylase activator activity(GO:0042978)
0.0	0.2	GO:0048020	CCR chemokine receptor binding(GO:0048020)
0.0	0.2	GO:0004668	protein-arginine deiminase activity(GO:0004668)
0.0	0.1	GO:0033130	acetylcholine receptor binding(GO:0033130)
0.0	0.2	GO:0042805	actinin binding(GO:0042805)
0.0	0.1	GO:0017159	pantetheine hydrolase activity(GO:0017159)
0.0	0.2	GO:0048027	mRNA 5'-UTR binding(GO:0048027)
0.0	0.4	GO:0048407	platelet-derived growth factor binding(GO:0048407)
0.0	0.0	GO:0005006	epidermal growth factor-activated receptor activity(GO:0005006)
0.0	0.2	GO:0048406	nerve growth factor binding(GO:0048406)
0.0	0.1	GO:0016901	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor(GO:0016901)
0.0	0.2	GO:0005161	platelet-derived growth factor receptor binding(GO:0005161)
0.0	0.0	GO:0070273	phosphatidylinositol-4-phosphate binding(GO:0070273)
0.0	0.1	GO:0004157	dihydropyrimidinase activity(GO:0004157)
0.0	0.1	GO:0016886	ligase activity, forming phosphoric ester bonds(GO:0016886)
0.0	0.1	GO:0050508	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.0	0.1	GO:0071553	uridine nucleotide receptor activity(GO:0015065) G-protein coupled pyrimidinergic nucleotide receptor activity(GO:0071553)
0.0	0.3	GO:0030247	pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0	0.1	GO:0030172	troponin C binding(GO:0030172)
0.0	0.2	GO:0017166	vinculin binding(GO:0017166)
0.0	0.1	GO:0035252	UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285)
0.0	0.1	GO:0070324	thyroid hormone binding(GO:0070324)
0.0	0.2	GO:0005110	frizzled-2 binding(GO:0005110)
0.0	0.1	GO:0005173	stem cell factor receptor binding(GO:0005173)
0.0	0.1	GO:0008475	procollagen-lysine 5-dioxygenase activity(GO:0008475)
0.0	0.1	GO:0017128	phospholipid scramblase activity(GO:0017128)
0.0	0.2	GO:0005172	vascular endothelial growth factor receptor binding(GO:0005172)
0.0	0.3	GO:0005523	tropomyosin binding(GO:0005523)
0.0	0.1	GO:0015016	[heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0	0.2	GO:0070696	transmembrane receptor protein serine/threonine kinase binding(GO:0070696)
0.0	0.1	GO:0031821	G-protein coupled serotonin receptor binding(GO:0031821)
0.0	0.1	GO:0003953	NAD+ nucleosidase activity(GO:0003953)
0.0	0.1	GO:0008486	diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486)
0.0	0.1	GO:0005534	galactose binding(GO:0005534)
0.0	0.1	GO:0050265	RNA uridylyltransferase activity(GO:0050265)
0.0	0.3	GO:0047555	3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.0	0.1	GO:0070644	vitamin D response element binding(GO:0070644)
0.0	0.1	GO:0017154	semaphorin receptor activity(GO:0017154)
0.0	0.1	GO:0004470	malic enzyme activity(GO:0004470)
0.0	0.1	GO:0051637	obsolete Gram-positive bacterial cell surface binding(GO:0051637)
0.0	0.1	GO:0050501	hyaluronan synthase activity(GO:0050501)
0.0	0.1	GO:0042808	obsolete neuronal Cdc2-like kinase binding(GO:0042808)
0.0	0.1	GO:0033765	steroid dehydrogenase activity, acting on the CH-CH group of donors(GO:0033765)
0.0	0.2	GO:0042171	1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) lysophosphatidic acid acyltransferase activity(GO:0042171) lysophospholipid acyltransferase activity(GO:0071617)
0.0	0.1	GO:0070290	N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0	0.1	GO:0000293	ferric-chelate reductase activity(GO:0000293)
0.0	0.1	GO:0045545	syndecan binding(GO:0045545)
0.0	0.2	GO:0000339	RNA cap binding(GO:0000339)
0.0	0.1	GO:0003836	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0	0.0	GO:0043559	insulin binding(GO:0043559)
0.0	0.1	GO:0008253	5'-nucleotidase activity(GO:0008253)
0.0	0.1	GO:0031994	insulin-like growth factor I binding(GO:0031994)
0.0	0.1	GO:0052743	inositol tetrakisphosphate phosphatase activity(GO:0052743)
0.0	0.1	GO:0003680	AT DNA binding(GO:0003680)
0.0	0.1	GO:0015220	choline transmembrane transporter activity(GO:0015220)
0.0	0.0	GO:0070815	peptidyl-lysine 5-dioxygenase activity(GO:0070815)
0.0	0.1	GO:0010314	phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0	0.1	GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.0	0.1	GO:0004075	biotin carboxylase activity(GO:0004075)
0.0	0.1	GO:0004791	thioredoxin-disulfide reductase activity(GO:0004791)
0.0	0.0	GO:1901567	icosanoid binding(GO:0050542) fatty acid derivative binding(GO:1901567)
0.0	0.1	GO:0003987	acetate-CoA ligase activity(GO:0003987)
0.0	0.4	GO:0004364	glutathione transferase activity(GO:0004364)
0.0	0.1	GO:0016724	ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0	0.1	GO:0004716	receptor signaling protein tyrosine kinase activity(GO:0004716)
0.0	0.8	GO:0008009	chemokine activity(GO:0008009)
0.0	0.0	GO:0004967	glucagon receptor activity(GO:0004967)
0.0	0.0	GO:0005127	ciliary neurotrophic factor receptor binding(GO:0005127)
0.0	0.1	GO:0004300	enoyl-CoA hydratase activity(GO:0004300)
0.0	0.1	GO:0030215	semaphorin receptor binding(GO:0030215)
0.0	0.1	GO:0004597	peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.0	0.1	GO:0003708	retinoic acid receptor activity(GO:0003708)
0.0	0.1	GO:0005042	netrin receptor activity(GO:0005042)
0.0	0.4	GO:0005158	insulin receptor binding(GO:0005158)
0.0	0.1	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0	0.0	GO:0004924	oncostatin-M receptor activity(GO:0004924)
0.0	0.0	GO:0004705	JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0	0.2	GO:0008271	secondary active sulfate transmembrane transporter activity(GO:0008271)
0.0	0.1	GO:0004645	phosphorylase activity(GO:0004645)
0.0	0.2	GO:0070064	proline-rich region binding(GO:0070064)
0.0	0.1	GO:0051635	obsolete bacterial cell surface binding(GO:0051635)
0.0	0.0	GO:0050220	prostaglandin-E synthase activity(GO:0050220)
0.0	0.0	GO:0015193	L-proline transmembrane transporter activity(GO:0015193)
0.0	0.0	GO:0034056	estrogen response element binding(GO:0034056)
0.0	0.0	GO:0004366	glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
0.0	0.0	GO:0004999	vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.0	0.2	GO:0016641	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641)
0.0	0.0	GO:0016647	oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.0	0.1	GO:0001595	angiotensin receptor activity(GO:0001595) angiotensin type II receptor activity(GO:0004945)
0.0	0.3	GO:0017046	peptide hormone binding(GO:0017046)
0.0	0.0	GO:0097493	extracellular matrix constituent conferring elasticity(GO:0030023) structural molecule activity conferring elasticity(GO:0097493)
0.0	0.0	GO:0019870	potassium channel inhibitor activity(GO:0019870)
0.0	0.1	GO:0045499	chemorepellent activity(GO:0045499)
0.0	0.1	GO:0005078	MAP-kinase scaffold activity(GO:0005078)
0.0	0.2	GO:0030971	receptor tyrosine kinase binding(GO:0030971) protein tyrosine kinase binding(GO:1990782)
0.0	0.0	GO:0004032	alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.0	0.2	GO:0042301	phosphate ion binding(GO:0042301)
0.0	0.0	GO:0004813	alanine-tRNA ligase activity(GO:0004813)
0.0	0.1	GO:0004614	phosphoglucomutase activity(GO:0004614)
0.0	0.1	GO:0015279	store-operated calcium channel activity(GO:0015279)
0.0	0.1	GO:0008401	retinoic acid 4-hydroxylase activity(GO:0008401)
0.0	0.2	GO:0070566	adenylyltransferase activity(GO:0070566)
0.0	0.1	GO:0008048	calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.0	0.0	GO:0000268	peroxisome targeting sequence binding(GO:0000268)
0.0	0.0	GO:0010485	H4 histone acetyltransferase activity(GO:0010485)
0.0	0.1	GO:0008046	axon guidance receptor activity(GO:0008046)
0.0	0.0	GO:0016635	oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor(GO:0016635)
0.0	0.1	GO:0047035	testosterone dehydrogenase (NAD+) activity(GO:0047035)
0.0	0.0	GO:0050998	nitric-oxide synthase binding(GO:0050998)
0.0	0.1	GO:0005021	vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0	0.1	GO:0004046	aminoacylase activity(GO:0004046)
0.0	0.1	GO:0016248	channel inhibitor activity(GO:0016248)
0.0	0.0	GO:0008061	chitin binding(GO:0008061)
0.0	0.1	GO:0016813	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.0	0.0	GO:0050510	N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510)
0.0	0.1	GO:0017110	nucleoside-diphosphatase activity(GO:0017110)
0.0	0.1	GO:0004862	cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0	0.1	GO:0003796	lysozyme activity(GO:0003796)
0.0	0.0	GO:0008502	melatonin receptor activity(GO:0008502)
0.0	0.0	GO:0004815	aspartate-tRNA ligase activity(GO:0004815)
0.0	0.0	GO:0019215	intermediate filament binding(GO:0019215)
0.0	0.0	GO:0004167	dopachrome isomerase activity(GO:0004167)
0.0	0.0	GO:0004656	procollagen-proline 4-dioxygenase activity(GO:0004656) peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.0	0.2	GO:0005104	fibroblast growth factor receptor binding(GO:0005104)
0.0	0.0	GO:0004030	aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.0	0.0	GO:0004045	aminoacyl-tRNA hydrolase activity(GO:0004045)
0.0	0.1	GO:0043395	heparan sulfate proteoglycan binding(GO:0043395)
0.0	0.1	GO:0000403	Y-form DNA binding(GO:0000403)
0.0	0.0	GO:0004346	glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.0	0.1	GO:0051787	misfolded protein binding(GO:0051787)
0.0	0.1	GO:0004467	long-chain fatty acid-CoA ligase activity(GO:0004467)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.0	SA B CELL RECEPTOR COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.1	PID AMB2 NEUTROPHILS PATHWAY	amb2 Integrin signaling
0.2	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
0.3	ST G ALPHA S PATHWAY	G alpha s Pathway
0.7	NABA COLLAGENS	Genes encoding collagen proteins
0.0	PID IFNG PATHWAY	IFN-gamma pathway
0.1	PID NFKAPPAB ATYPICAL PATHWAY	Atypical NF-kappaB pathway
0.1	ST INTEGRIN SIGNALING PATHWAY	Integrin Signaling Pathway
0.3	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0	NABA BASEMENT MEMBRANES	Genes encoding structural components of basement membranes
0.0	ST GAQ PATHWAY	G alpha q Pathway
0.2	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.1	PID NETRIN PATHWAY	Netrin-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.1	REACTOME DAG AND IP3 SIGNALING	Genes involved in DAG and IP3 signaling
0.0	0.4	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.0	0.9	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.0	0.0	REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE	Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0	0.6	REACTOME CGMP EFFECTS	Genes involved in cGMP effects
0.0	0.1	REACTOME SHC1 EVENTS IN EGFR SIGNALING	Genes involved in SHC1 events in EGFR signaling
0.0	0.1	REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION	Genes involved in activated TAK1 mediates p38 MAPK activation
0.0	0.1	REACTOME REGULATION OF KIT SIGNALING	Genes involved in Regulation of KIT signaling
0.0	0.0	REACTOME G ALPHA Z SIGNALLING EVENTS	Genes involved in G alpha (z) signalling events
0.0	0.2	REACTOME ROLE OF DCC IN REGULATING APOPTOSIS	Genes involved in Role of DCC in regulating apoptosis
0.0	0.4	REACTOME PYRIMIDINE METABOLISM	Genes involved in Pyrimidine metabolism
0.0	0.5	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.0	0.2	REACTOME SIGNAL ATTENUATION	Genes involved in Signal attenuation
0.0	0.0	REACTOME IL 3 5 AND GM CSF SIGNALING	Genes involved in Interleukin-3, 5 and GM-CSF signaling
0.0	0.3	REACTOME SIGNALING BY HIPPO	Genes involved in Signaling by Hippo
0.0	0.3	REACTOME GLUTATHIONE CONJUGATION	Genes involved in Glutathione conjugation
0.0	0.1	REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0	0.3	REACTOME SIGNALING BY BMP	Genes involved in Signaling by BMP
0.0	0.1	REACTOME CREATION OF C4 AND C2 ACTIVATORS	Genes involved in Creation of C4 and C2 activators
0.0	0.1	REACTOME PURINE CATABOLISM	Genes involved in Purine catabolism
0.0	0.7	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.0	0.3	REACTOME ADP SIGNALLING THROUGH P2RY12	Genes involved in ADP signalling through P2Y purinoceptor 12
0.0	0.2	REACTOME SHC1 EVENTS IN ERBB4 SIGNALING	Genes involved in SHC1 events in ERBB4 signaling
0.0	0.0	REACTOME NRAGE SIGNALS DEATH THROUGH JNK	Genes involved in NRAGE signals death through JNK
0.0	0.3	REACTOME AMINE COMPOUND SLC TRANSPORTERS	Genes involved in Amine compound SLC transporters
0.0	0.1	REACTOME COMMON PATHWAY	Genes involved in Common Pathway
0.0	0.4	REACTOME HS GAG BIOSYNTHESIS	Genes involved in HS-GAG biosynthesis
0.0	0.0	REACTOME ARMS MEDIATED ACTIVATION	Genes involved in ARMS-mediated activation
0.0	0.1	REACTOME PEROXISOMAL LIPID METABOLISM	Genes involved in Peroxisomal lipid metabolism
0.0	0.2	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.0	0.1	REACTOME PROLACTIN RECEPTOR SIGNALING	Genes involved in Prolactin receptor signaling