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ENCODE: H3K4me1 ChIP-Seq of primary human cells
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Results for NKX6-3

Z-value: 1.12

Motif logo

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Transcription factors associated with NKX6-3

Gene Symbol Gene ID Gene Info
NKX6-3
ENSG00000165066.11 NK6 homeobox 3

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr8_41503976_41504252NKX6-37640.5399930.521.6e-01Click!
chr8_41512290_41512441NKX6-335100.156058-0.511.6e-01Click!
chr8_41506141_41506292NKX6-313380.326383-0.422.6e-01Click!
chr8_41503640_41503791NKX6-311630.3734070.393.0e-01Click!
chr8_41503291_41503442NKX6-315120.2915930.363.4e-01Click!

Activity of the NKX6-3 motif across conditions

Conditions sorted by the z-value of the NKX6-3 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr11_33712841_33713004 1.02 RP4-541C22.5
5325
 0.18
chr22_18539461_18539695 0.88 XXbac-B476C20.9
20985
 0.13
chr11_102722401_102722552 0.83 MMP3
 matrix metallopeptidase 3 (stromelysin 1, progelatinase)
 7942
 0.19
chr4_145504640_145504791 0.77 HHIP-AS1
 HHIP antisense RNA 1
 62349
 0.14
chr9_14251921_14252072 0.73 NFIB
 nuclear factor I/B
 56016
 0.15
chr6_114196551_114196945 0.73 MARCKS
 myristoylated alanine-rich protein kinase C substrate
 18207
 0.17
chr6_52425530_52425681 0.66 TRAM2
 translocation associated membrane protein 2
 16108
 0.24
chr1_206603221_206603372 0.61 SRGAP2
 SLIT-ROBO Rho GTPase activating protein 2
 20488
 0.16
chr12_10545690_10545841 0.60 KLRK1
 killer cell lectin-like receptor subfamily K, member 1
 3148
 0.16
chr2_225681896_225682047 0.58 DOCK10
 dedicator of cytokinesis 10
 602
 0.85
chr10_65460709_65460902 0.58 REEP3
 receptor accessory protein 3
 179682
 0.03
chr5_139626504_139626769 0.57 CTB-131B5.2
46888
 0.09
chr17_61357894_61358045 0.57 RP11-269G24.2
32913
 0.16
chr3_177651530_177651798 0.56 ENSG00000199858
 .
 73903
 0.13
chr2_48571922_48572463 0.56 ENSG00000251889
 .
 4227
 0.27
chr16_27590290_27590441 0.56 KIAA0556
 KIAA0556
 5137
 0.22
chr5_16890159_16890310 0.55 MYO10
 myosin X
 26402
 0.18
chr4_47215322_47215473 0.55 ENSG00000238301
 .
 92657
 0.09
chr4_14728667_14728818 0.53 ENSG00000202449
 .
 36408
 0.24
chr5_158370461_158370612 0.53 CTD-2363C16.1
39478
 0.18
chr3_188995375_188995558 0.52 TPRG1-AS2
 TPRG1 antisense RNA 2
 37083
 0.21
chr14_54405199_54405350 0.52 ENSG00000266431
 .
 9928
 0.25
chr4_187608141_187608292 0.52 FAT1
 FAT atypical cadherin 1
 36793
 0.2
chr5_64504974_64505125 0.51 ENSG00000207439
 .
 85853
 0.1
chr7_72619380_72619686 0.51 NCF1B
 neutrophil cytosolic factor 1B pseudogene
 15078
 0.17
chr4_125335710_125335861 0.51 ANKRD50
 ankyrin repeat domain 50
 298102
 0.01
chr17_454384_454535 0.50 RP5-1029F21.2
1347
 0.44
chr16_84765282_84765475 0.50 USP10
 ubiquitin specific peptidase 10
 31732
 0.17
chr3_149298844_149298995 0.50 WWTR1
 WW domain containing transcription regulator 1
 4880
 0.23
chr6_56591218_56591369 0.49 DST
 dystonin
 59384
 0.15
chr6_44414403_44414554 0.49 ENSG00000266619
 .
 11100
 0.18
chr6_158591128_158591427 0.48 GTF2H5
 general transcription factor IIH, polypeptide 5
 1893
 0.27
chr2_150601107_150601258 0.48 ENSG00000207270
 .
 133894
 0.05
chr22_33108393_33108637 0.48 LL22NC01-116C6.1
70648
 0.1
chr11_111685692_111685843 0.48 ALG9-IT1
 ALG9 intronic transcript 1 (non-protein coding)
 14169
 0.14
chr12_10344371_10344522 0.48 TMEM52B
 transmembrane protein 52B
 12333
 0.12
chr1_246132469_246132620 0.47 RP11-83A16.1
64309
 0.14
chr2_182941626_182941777 0.47 ENSG00000265129
 .
 11642
 0.22
chr8_131156068_131156219 0.47 ENSG00000212342
 .
 19075
 0.2
chr1_67397953_67399117 0.46 MIER1
 mesoderm induction early response 1, transcriptional regulator
 2609
 0.29
chr8_126231993_126232161 0.46 ENSG00000242170
 .
 50769
 0.15
chr2_217461850_217462001 0.46 AC073321.3
9736
 0.19
chr10_28601668_28601819 0.46 ENSG00000222374
 .
 1961
 0.37
chr4_170165351_170165677 0.44 SH3RF1
 SH3 domain containing ring finger 1
 25594
 0.22
chr6_161590013_161590164 0.44 AGPAT4
 1-acylglycerol-3-phosphate O-acyltransferase 4
 19767
 0.28
chr18_46056441_46056592 0.44 CTIF
 CBP80/20-dependent translation initiation factor
 8901
 0.25
chr2_153441109_153441260 0.44 FMNL2
 formin-like 2
 34908
 0.22
chr1_222341096_222341247 0.44 ENSG00000212094
 .
 154739
 0.04
chr7_112636182_112636333 0.43 C7orf60
 chromosome 7 open reading frame 60
 56286
 0.14
chr7_42233492_42233928 0.43 GLI3
 GLI family zinc finger 3
 33610
 0.25
chr20_11120768_11120919 0.43 C20orf187
 chromosome 20 open reading frame 187
 112032
 0.07
chr4_41150165_41150316 0.43 ENSG00000207198
 .
 34281
 0.16
chr3_188067044_188067254 0.42 LPP
 LIM domain containing preferred translocation partner in lipoma
 109497
 0.07
chr14_101459833_101459984 0.42 ENSG00000200089
 .
 335
 0.31
chr4_141866091_141866242 0.42 RNF150
 ring finger protein 150
 52024
 0.17
chr8_128755138_128755289 0.42 MYC
 v-myc avian myelocytomatosis viral oncogene homolog
 6736
 0.28
chr4_186196562_186196713 0.42 SNX25
 sorting nexin 25
 65404
 0.09
chr17_17640963_17641296 0.41 RAI1-AS1
 RAI1 antisense RNA 1
 33006
 0.11
chr9_75764547_75765336 0.41 ANXA1
 annexin A1
 1732
 0.5
chr13_43580173_43580324 0.41 EPSTI1
 epithelial stromal interaction 1 (breast)
 13863
 0.24
chr12_27763041_27763300 0.40 PPFIBP1
 PTPRF interacting protein, binding protein 1 (liprin beta 1)
 10889
 0.22
chr15_72045393_72045544 0.40 CTD-2524L6.3
65269
 0.12
chr12_125160668_125160889 0.40 NCOR2
 nuclear receptor corepressor 2
 108768
 0.07
chr2_46325558_46325709 0.40 AC017006.2
19666
 0.24
chr10_71734773_71734924 0.40 COL13A1
 collagen, type XIII, alpha 1
 44639
 0.15
chr8_58980536_58980687 0.40 FAM110B
 family with sequence similarity 110, member B
 73498
 0.13
chr11_111848937_111849153 0.39 DIXDC1
 DIX domain containing 1
 1012
 0.41
chr3_188104571_188104722 0.39 LPP
 LIM domain containing preferred translocation partner in lipoma
 146994
 0.04
chr2_196547314_196547465 0.39 ENSG00000201813
 .
 12191
 0.23
chr11_110228298_110228580 0.39 RDX
 radixin
 60992
 0.14
chr6_79614930_79615081 0.39 IRAK1BP1
 interleukin-1 receptor-associated kinase 1 binding protein 1
 7096
 0.29
chr2_55328902_55329053 0.38 ENSG00000266376
 .
 6869
 0.2
chr12_89461977_89462128 0.38 ENSG00000238302
 .
 214010
 0.02
chr12_94181628_94181779 0.38 ENSG00000264978
 .
 43149
 0.13
chr6_139293869_139294337 0.38 REPS1
 RALBP1 associated Eps domain containing 1
 14674
 0.24
chr11_60686848_60686999 0.38 TMEM109
 transmembrane protein 109
 227
 0.84
chr4_7881276_7881455 0.38 AFAP1
 actin filament associated protein 1
 7325
 0.25
chr7_116211652_116211947 0.38 AC006159.4
511
 0.78
chr16_74514100_74514392 0.37 ENSG00000207525
 .
 16360
 0.16
chr2_161608908_161609059 0.37 ENSG00000244372
 .
 125075
 0.06
chr11_65047025_65047288 0.37 POLA2
 polymerase (DNA directed), alpha 2, accessory subunit
 2822
 0.18
chr2_197264610_197264832 0.37 HECW2
 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
 37775
 0.2
chr6_108975764_108975915 0.37 FOXO3
 forkhead box O3
 1710
 0.51
chr4_55408709_55408988 0.37 KIT
 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
 115237
 0.07
chr7_129933263_129933414 0.36 CPA4
 carboxypeptidase A4
 219
 0.91
chrX_39832066_39832217 0.36 BCOR
 BCL6 corepressor
 90049
 0.09
chr11_126788305_126788456 0.36 KIRREL3-AS2
 KIRREL3 antisense RNA 2
 22262
 0.2
chr8_143757168_143757384 0.36 PSCA
 prostate stem cell antigen
 4598
 0.13
chr1_8138703_8138854 0.36 ERRFI1
 ERBB receptor feedback inhibitor 1
 52410
 0.13
chr8_90739175_90739326 0.36 RIPK2
 receptor-interacting serine-threonine kinase 2
 30725
 0.24
chr8_91783068_91783219 0.36 NECAB1
 N-terminal EF-hand calcium binding protein 1
 20635
 0.19
chr3_182992678_182993398 0.35 B3GNT5
 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
 9906
 0.2
chr4_154388689_154389189 0.35 KIAA0922
 KIAA0922
 1438
 0.51
chr3_197098695_197098846 0.35 ENSG00000238491
 .
 32348
 0.17
chr2_47101079_47101246 0.35 AC016722.3
20527
 0.13
chr5_95064137_95064401 0.35 RHOBTB3
 Rho-related BTB domain containing 3
 2307
 0.25
chr2_36581626_36581777 0.35 CRIM1
 cysteine rich transmembrane BMP regulator 1 (chordin-like)
 1368
 0.59
chr5_72327163_72327314 0.35 ENSG00000200833
 .
 68662
 0.09
chr10_31604223_31604374 0.35 ENSG00000237036
 .
 3563
 0.23
chr2_161232105_161232912 0.34 ENSG00000252465
 .
 20971
 0.19
chr3_145882013_145882164 0.34 PLOD2
 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
 648
 0.77
chr10_89536127_89536278 0.34 ATAD1
 ATPase family, AAA domain containing 1
 16312
 0.18
chr6_15095366_15095517 0.34 ENSG00000242989
 .
 17758
 0.25
chr7_106873690_106873841 0.34 HBP1
 HMG-box transcription factor 1
 37472
 0.15
chr8_53031421_53031572 0.34 RP11-26M5.3
31884
 0.21
chr10_80832109_80832421 0.34 ZMIZ1
 zinc finger, MIZ-type containing 1
 3473
 0.29
chr8_107951495_107951646 0.34 ABRA
 actin-binding Rho activating protein
 169097
 0.04
chr7_116350835_116350986 0.34 MET
 met proto-oncogene
 11771
 0.25
chr12_14990014_14990290 0.33 RP11-233G1.4
3874
 0.14
chr7_36487948_36488099 0.33 AC006960.7
14609
 0.19
chr8_38259724_38259888 0.33 RP11-350N15.3
605
 0.59
chr18_73120073_73120224 0.33 RP11-321M21.3
 HCG1996301; Uncharacterized protein
 1181
 0.58
chr11_131765892_131766043 0.33 AP004372.1
1035
 0.61
chr5_142682227_142682378 0.33 ARHGAP26
 Rho GTPase activating protein 26
 95537
 0.08
chr16_24742094_24743166 0.33 TNRC6A
 trinucleotide repeat containing 6A
 1596
 0.5
chr1_198874035_198874197 0.33 ENSG00000207759
 .
 45834
 0.17
chr4_26344038_26344485 0.33 RBPJ
 recombination signal binding protein for immunoglobulin kappa J region
 501
 0.88
chr1_113666672_113666823 0.33 LRIG2
 leucine-rich repeats and immunoglobulin-like domains 2
 50916
 0.17
chr9_80078507_80078658 0.33 RP11-466A17.1
7371
 0.28
chr20_45905361_45905512 0.33 ZMYND8
 zinc finger, MYND-type containing 8
 22208
 0.14
chr2_218258772_218258923 0.33 ENSG00000251982
 .
 142568
 0.05
chr1_172855064_172855215 0.33 TNFSF18
 tumor necrosis factor (ligand) superfamily, member 18
 164917
 0.04
chr6_117769723_117769874 0.32 ENSG00000221434
 .
 3245
 0.19
chr4_170081579_170081730 0.32 RP11-327O17.2
41291
 0.18
chr6_21004450_21004601 0.32 ENSG00000252046
 .
 10726
 0.32
chr14_52795656_52796058 0.32 PTGER2
 prostaglandin E receptor 2 (subtype EP2), 53kDa
 14744
 0.25
chr3_150422131_150422452 0.32 RP11-103G8.2
461
 0.51
chr10_29772721_29772872 0.32 SVIL
 supervillin
 12651
 0.23
chr11_28855936_28856087 0.32 ENSG00000211499
 .
 442225
 0.01
chr2_142315504_142315655 0.32 ENSG00000265224
 .
 80834
 0.12
chr16_81638343_81638641 0.32 CMIP
 c-Maf inducing protein
 40471
 0.2
chr10_62187776_62187927 0.31 ANK3
 ankyrin 3, node of Ranvier (ankyrin G)
 38363
 0.23
chr2_56181551_56181702 0.31 ENSG00000202344
 .
 2477
 0.26
chr6_38228109_38228260 0.31 ENSG00000200706
 .
 53134
 0.16
chr4_184558434_184558585 0.31 ENSG00000252157
 .
 16320
 0.14
chr3_45521464_45521615 0.31 LARS2-AS1
 LARS2 antisense RNA 1
 29498
 0.2
chr3_136505593_136506225 0.31 SLC35G2
 solute carrier family 35, member G2
 31952
 0.12
chr17_39218871_39219022 0.31 KRTAP2-3
 keratin associated protein 2-3
 2602
 0.09
chr18_67711328_67711479 0.30 RTTN
 rotatin
 23449
 0.25
chr8_77711424_77711575 0.30 ZFHX4
 zinc finger homeobox 4
 95219
 0.08
chr12_66345138_66345289 0.30 RP11-366L20.3
2954
 0.27
chr2_43986548_43986990 0.30 ENSG00000252490
 .
 12720
 0.19
chr14_90557642_90557793 0.30 KCNK13
 potassium channel, subfamily K, member 13
 29608
 0.2
chr11_20505330_20505481 0.30 PRMT3
 protein arginine methyltransferase 3
 96143
 0.08
chr4_15013014_15013165 0.30 CPEB2
 cytoplasmic polyadenylation element binding protein 2
 7529
 0.3
chr1_25666704_25667414 0.30 ENSG00000252515
 .
 403
 0.75
chr5_57485225_57485376 0.30 ENSG00000238899
 .
 119285
 0.06
chr12_65288524_65288675 0.30 ENSG00000221564
 .
 44204
 0.15
chr1_61989098_61989249 0.30 ENSG00000264551
 .
 105530
 0.07
chr4_183161080_183161231 0.30 TENM3
 teneurin transmembrane protein 3
 3427
 0.32
chrX_41135797_41136128 0.30 ENSG00000199564
 .
 16089
 0.18
chr9_117877775_117877926 0.30 TNC
 tenascin C
 2628
 0.36
chr11_74659216_74659741 0.30 XRRA1
 X-ray radiation resistance associated 1
 587
 0.48
chr10_62570411_62570562 0.30 CDK1
 cyclin-dependent kinase 1
 30575
 0.22
chr1_198226866_198227037 0.30 NEK7
 NIMA-related kinase 7
 37022
 0.23
chr2_145088605_145089481 0.30 GTDC1
 glycosyltransferase-like domain containing 1
 1040
 0.68
chr1_198238756_198238907 0.30 NEK7
 NIMA-related kinase 7
 48902
 0.19
chr13_51104174_51104472 0.29 ENSG00000221198
 .
 166950
 0.04
chr15_45881879_45882313 0.29 BLOC1S6
 biogenesis of lysosomal organelles complex-1, subunit 6, pallidin
 2073
 0.2
chr1_165739030_165739243 0.29 TMCO1
 transmembrane and coiled-coil domains 1
 719
 0.5
chr7_13985521_13985672 0.29 ETV1
 ets variant 1
 40470
 0.2
chr15_38690005_38690267 0.29 FAM98B
 family with sequence similarity 98, member B
 56192
 0.14
chr2_9171149_9171380 0.29 MBOAT2
 membrane bound O-acyltransferase domain containing 2
 27322
 0.22
chr3_149189968_149190119 0.29 TM4SF4
 transmembrane 4 L six family member 4
 1718
 0.4
chr12_67665547_67665828 0.29 CAND1
 cullin-associated and neddylation-dissociated 1
 2006
 0.5
chr18_43819137_43819353 0.29 C18orf25
 chromosome 18 open reading frame 25
 65245
 0.11
chr7_137534903_137535054 0.29 DGKI
 diacylglycerol kinase, iota
 3140
 0.34
chr6_111273369_111273520 0.29 GTF3C6
 general transcription factor IIIC, polypeptide 6, alpha 35kDa
 6319
 0.15
chr4_24069141_24069414 0.29 PPARGC1A
 peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
 177577
 0.03
chr4_138974616_138974767 0.29 ENSG00000250033
 .
 3927
 0.38
chr3_151985241_151985971 0.29 MBNL1
 muscleblind-like splicing regulator 1
 223
 0.93
chr2_225027538_225027689 0.29 ENSG00000211987
 .
 76660
 0.11
chr14_80052151_80052302 0.29 RP11-242P2.2
47428
 0.2
chr1_179148045_179148196 0.29 ENSG00000212338
 .
 17488
 0.17
chr4_138975505_138975656 0.28 ENSG00000250033
 .
 3038
 0.41
chr21_28941972_28942234 0.28 ADAMTS5
 ADAM metallopeptidase with thrombospondin type 1 motif, 5
 603271
 0.0
chr2_179070454_179070605 0.28 OSBPL6
 oxysterol binding protein-like 6
 11153
 0.22
chr9_89952372_89952738 0.28 ENSG00000212421
 .
 77190
 0.11
chr10_15368183_15368334 0.28 FAM171A1
 family with sequence similarity 171, member A1
 44800
 0.17
chr20_37614000_37614151 0.28 DHX35
 DEAH (Asp-Glu-Ala-His) box polypeptide 35
 23088
 0.18
chr8_29109260_29109557 0.28 KIF13B
 kinesin family member 13B
 11182
 0.17
chr8_25032357_25032508 0.28 ENSG00000241811
 .
 6803
 0.25
chr5_64459127_64459278 0.28 ENSG00000207439
 .
 40006
 0.22
chr10_95235571_95235788 0.28 MYOF
 myoferlin
 6272
 0.2
chr2_100218822_100218973 0.28 AFF3
 AF4/FMR2 family, member 3
 24065
 0.23
chr21_40683413_40684326 0.28 BRWD1
 bromodomain and WD repeat domain containing 1
 1627
 0.24
chr5_92694884_92695035 0.28 ENSG00000237187
 .
 63160
 0.15
chr8_128937773_128937924 0.28 TMEM75
 transmembrane protein 75
 22743
 0.19
chr2_1657675_1657826 0.28 AC144450.1
33865
 0.19
chr5_154158547_154158698 0.28 LARP1
 La ribonucleoprotein domain family, member 1
 13671
 0.17
chr3_142719040_142719191 0.28 U2SURP
 U2 snRNP-associated SURP domain containing
 1251
 0.46
chr1_150450551_150450702 0.28 TARS2
 threonyl-tRNA synthetase 2, mitochondrial (putative)
 9261
 0.13
chr10_59788519_59788670 0.28 ENSG00000238970
 .
 209927
 0.02
chr1_61918584_61919140 0.28 NFIA
 nuclear factor I/A
 46518
 0.19
chr5_92353866_92354017 0.28 ENSG00000221810
 .
 300721
 0.01
chr5_76134379_76134541 0.28 ENSG00000264391
 .
 1440
 0.37
chr16_58597342_58597493 0.28 ENSG00000206952
 .
 3582
 0.17
chr18_30492153_30492304 0.27 RP11-680N20.1
41811
 0.18
chr1_76231815_76231966 0.27 RABGGTB
 Rab geranylgeranyltransferase, beta subunit
 19989
 0.11
chr12_10544948_10545233 0.27 KLRK1
 killer cell lectin-like receptor subfamily K, member 1
 2473
 0.19

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX6-3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.1 0.2 GO:0060831 smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:0060831)
0.1 0.2 GO:1901722 regulation of cell proliferation involved in kidney development(GO:1901722)
0.0 0.2 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
0.0 0.1 GO:0010757 negative regulation of plasminogen activation(GO:0010757)
0.0 0.2 GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.0 0.1 GO:0010837 regulation of keratinocyte proliferation(GO:0010837)
0.0 0.2 GO:0007256 activation of JNKK activity(GO:0007256)
0.0 0.1 GO:0045046 protein import into peroxisome membrane(GO:0045046)
0.0 0.1 GO:0071481 cellular response to X-ray(GO:0071481)
0.0 0.2 GO:0001547 antral ovarian follicle growth(GO:0001547)
0.0 0.1 GO:0010761 fibroblast migration(GO:0010761)
0.0 0.1 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0 0.1 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.0 0.1 GO:0050774 negative regulation of dendrite morphogenesis(GO:0050774)
0.0 0.2 GO:0060390 regulation of SMAD protein import into nucleus(GO:0060390)
0.0 0.1 GO:0007144 female meiosis I(GO:0007144)
0.0 0.1 GO:0006166 purine ribonucleoside salvage(GO:0006166)
0.0 0.1 GO:0015825 L-serine transport(GO:0015825)
0.0 0.1 GO:0007028 cytoplasm organization(GO:0007028)
0.0 0.1 GO:0072385 minus-end-directed organelle transport along microtubule(GO:0072385)
0.0 0.0 GO:0060686 negative regulation of prostatic bud formation(GO:0060686)
0.0 0.0 GO:0071504 cellular response to heparin(GO:0071504)
0.0 0.1 GO:0042797 5S class rRNA transcription from RNA polymerase III type 1 promoter(GO:0042791) tRNA transcription from RNA polymerase III promoter(GO:0042797)
0.0 0.2 GO:0009886 post-embryonic morphogenesis(GO:0009886)
0.0 0.0 GO:0090081 regulation of heart induction by regulation of canonical Wnt signaling pathway(GO:0090081)
0.0 0.2 GO:0097354 protein prenylation(GO:0018342) prenylation(GO:0097354)
0.0 0.1 GO:0046719 intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) regulation by virus of viral protein levels in host cell(GO:0046719) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708)
0.0 0.2 GO:0006896 Golgi to endosome transport(GO:0006895) Golgi to vacuole transport(GO:0006896)
0.0 0.0 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.0 0.1 GO:0001778 plasma membrane repair(GO:0001778)
0.0 0.0 GO:0072112 renal filtration cell differentiation(GO:0061318) glomerular epithelium development(GO:0072010) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.0 0.1 GO:0010842 retina layer formation(GO:0010842)
0.0 0.1 GO:0043589 skin morphogenesis(GO:0043589)
0.0 0.1 GO:0007412 axon target recognition(GO:0007412)
0.0 0.0 GO:0051771 negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771)
0.0 0.1 GO:0010566 regulation of ketone biosynthetic process(GO:0010566) regulation of aldosterone metabolic process(GO:0032344) regulation of aldosterone biosynthetic process(GO:0032347)
0.0 0.1 GO:0034695 response to prostaglandin E(GO:0034695)
0.0 0.0 GO:0035385 Roundabout signaling pathway(GO:0035385)
0.0 0.1 GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0 0.1 GO:0051305 chromosome movement towards spindle pole(GO:0051305)
0.0 0.4 GO:0030574 collagen catabolic process(GO:0030574)
0.0 0.0 GO:0070208 protein heterotrimerization(GO:0070208)
0.0 0.1 GO:0031657 regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle(GO:0031657) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle(GO:0031659)
0.0 0.1 GO:0070254 mucus secretion(GO:0070254)
0.0 0.1 GO:0060638 mesenchymal-epithelial cell signaling(GO:0060638)
0.0 0.0 GO:0021834 chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration(GO:0021834)
0.0 0.0 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.0 0.3 GO:1905037 autophagosome assembly(GO:0000045) autophagosome organization(GO:1905037)
0.0 0.1 GO:0048755 branching morphogenesis of a nerve(GO:0048755)
0.0 0.1 GO:0006435 threonyl-tRNA aminoacylation(GO:0006435)
0.0 0.1 GO:0009649 entrainment of circadian clock(GO:0009649)
0.0 0.1 GO:0060039 pericardium development(GO:0060039)
0.0 0.1 GO:0048149 behavioral response to ethanol(GO:0048149)
0.0 0.1 GO:0060040 retinal bipolar neuron differentiation(GO:0060040)
0.0 0.0 GO:0060235 lens induction in camera-type eye(GO:0060235)
0.0 0.4 GO:0048009 insulin-like growth factor receptor signaling pathway(GO:0048009)
0.0 0.1 GO:0006516 glycoprotein catabolic process(GO:0006516)
0.0 0.0 GO:0070050 neuron cellular homeostasis(GO:0070050)
0.0 0.0 GO:0001672 regulation of chromatin assembly or disassembly(GO:0001672)
0.0 0.0 GO:0060789 hair follicle placode formation(GO:0060789)
0.0 0.0 GO:0060648 mammary gland bud morphogenesis(GO:0060648)
0.0 0.0 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
0.0 0.0 GO:0048702 embryonic neurocranium morphogenesis(GO:0048702)
0.0 0.1 GO:0034501 protein localization to kinetochore(GO:0034501)
0.0 0.1 GO:0044314 protein K27-linked ubiquitination(GO:0044314)
0.0 0.1 GO:0007386 compartment pattern specification(GO:0007386)
0.0 0.0 GO:0032928 regulation of superoxide anion generation(GO:0032928)
0.0 0.0 GO:0015864 pyrimidine nucleoside transport(GO:0015864)
0.0 0.0 GO:0002541 activation of plasma proteins involved in acute inflammatory response(GO:0002541)
0.0 0.0 GO:0031536 positive regulation of exit from mitosis(GO:0031536)
0.0 0.1 GO:0001945 lymph vessel development(GO:0001945)
0.0 0.1 GO:0033261 obsolete regulation of S phase(GO:0033261)
0.0 0.0 GO:0016999 antibiotic metabolic process(GO:0016999) antibiotic biosynthetic process(GO:0017000)
0.0 0.1 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
0.0 0.1 GO:1901339 activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0 0.0 GO:0030505 inorganic diphosphate transport(GO:0030505)
0.0 0.1 GO:0000729 DNA double-strand break processing(GO:0000729)
0.0 0.0 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
0.0 0.0 GO:0002220 innate immune response activating cell surface receptor signaling pathway(GO:0002220)
0.0 0.2 GO:0032964 collagen biosynthetic process(GO:0032964)
0.0 0.0 GO:0008354 germ cell migration(GO:0008354)
0.0 0.0 GO:0070561 vitamin D receptor signaling pathway(GO:0070561)
0.0 0.0 GO:0000103 sulfate assimilation(GO:0000103)
0.0 0.0 GO:0033600 negative regulation of mammary gland epithelial cell proliferation(GO:0033600)
0.0 0.0 GO:0035511 oxidative DNA demethylation(GO:0035511)
0.0 0.0 GO:0034629 cellular protein complex localization(GO:0034629)
0.0 0.1 GO:0010700 negative regulation of norepinephrine secretion(GO:0010700)
0.0 0.0 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.0 0.1 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 0.2 GO:0043631 RNA polyadenylation(GO:0043631)
0.0 0.1 GO:0006853 carnitine shuttle(GO:0006853) carnitine transmembrane transport(GO:1902603)
0.0 0.2 GO:0030199 collagen fibril organization(GO:0030199)
0.0 0.1 GO:0072665 protein targeting to lysosome(GO:0006622) protein targeting to vacuole(GO:0006623) protein localization to lysosome(GO:0061462) protein localization to vacuole(GO:0072665) establishment of protein localization to vacuole(GO:0072666)
0.0 0.0 GO:0060242 contact inhibition(GO:0060242)
0.0 0.0 GO:0010966 regulation of phosphate transport(GO:0010966)
0.0 0.0 GO:0060457 negative regulation of digestive system process(GO:0060457)
0.0 0.0 GO:0043985 histone H4-R3 methylation(GO:0043985)
0.0 0.2 GO:0035195 gene silencing by miRNA(GO:0035195)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.1 GO:0030934 anchoring collagen complex(GO:0030934)
0.0 0.1 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.0 0.1 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673)
0.0 0.1 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 0.1 GO:0005787 signal peptidase complex(GO:0005787)
0.0 0.1 GO:0005954 calcium- and calmodulin-dependent protein kinase complex(GO:0005954)
0.0 0.2 GO:0030990 intraciliary transport particle(GO:0030990)
0.0 0.1 GO:0043656 host(GO:0018995) host cell part(GO:0033643) host intracellular part(GO:0033646) intracellular region of host(GO:0043656) host cell(GO:0043657) other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217)
0.0 0.1 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.0 0.1 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 0.1 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.0 0.1 GO:0032444 activin responsive factor complex(GO:0032444)
0.0 0.1 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.0 0.1 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.1 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.2 GO:0030867 rough endoplasmic reticulum membrane(GO:0030867)
0.0 0.1 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.0 0.0 GO:0071942 XPC complex(GO:0071942)
0.0 0.0 GO:0071778 obsolete WINAC complex(GO:0071778)
0.0 0.1 GO:0033268 node of Ranvier(GO:0033268)
0.0 0.1 GO:0002102 podosome(GO:0002102)
0.0 0.1 GO:0005916 fascia adherens(GO:0005916)
0.0 0.1 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 0.3 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 0.1 GO:0016600 flotillin complex(GO:0016600)
0.0 0.3 GO:0001533 cornified envelope(GO:0001533)
0.0 0.0 GO:0032133 chromosome passenger complex(GO:0032133)
0.0 0.1 GO:0000796 condensin complex(GO:0000796)
0.0 0.0 GO:0001740 Barr body(GO:0001740)
0.0 0.1 GO:0030122 AP-2 adaptor complex(GO:0030122) clathrin coat of endocytic vesicle(GO:0030128)
0.0 0.0 GO:0070552 BRISC complex(GO:0070552)
0.0 0.1 GO:0071564 npBAF complex(GO:0071564)
0.0 0.1 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 0.1 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.1 GO:0031010 ISWI-type complex(GO:0031010)
0.0 0.0 GO:0042272 nuclear RNA export factor complex(GO:0042272)
0.0 0.4 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 0.0 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.0 0.1 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.1 GO:0016272 prefoldin complex(GO:0016272)
0.0 0.0 GO:0005826 actomyosin contractile ring(GO:0005826)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0005010 insulin-like growth factor-activated receptor activity(GO:0005010)
0.1 0.3 GO:0008475 procollagen-lysine 5-dioxygenase activity(GO:0008475)
0.1 0.2 GO:0019834 phospholipase A2 inhibitor activity(GO:0019834)
0.1 0.2 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.0 0.1 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 0.1 GO:0016901 oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor(GO:0016901)
0.0 0.1 GO:0045545 syndecan binding(GO:0045545)
0.0 0.2 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0 0.1 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 0.1 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.0 0.1 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.0 0.1 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.0 0.1 GO:0015194 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.0 0.1 GO:0070700 BMP receptor binding(GO:0070700)
0.0 0.1 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0 0.3 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.1 GO:0004904 interferon receptor activity(GO:0004904)
0.0 0.1 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.1 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.0 0.2 GO:0005114 type II transforming growth factor beta receptor binding(GO:0005114)
0.0 0.1 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.5 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.1 GO:0047115 trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity(GO:0047115)
0.0 0.8 GO:0017048 Rho GTPase binding(GO:0017048)
0.0 0.1 GO:0003872 6-phosphofructokinase activity(GO:0003872)
0.0 0.1 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.0 0.1 GO:0050998 nitric-oxide synthase binding(GO:0050998)
0.0 0.1 GO:0030020 extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.0 0.1 GO:0031994 insulin-like growth factor I binding(GO:0031994)
0.0 0.1 GO:0008318 protein prenyltransferase activity(GO:0008318)
0.0 0.1 GO:0050508 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.0 0.1 GO:0070576 vitamin D 24-hydroxylase activity(GO:0070576)
0.0 0.1 GO:0008384 IkappaB kinase activity(GO:0008384)
0.0 0.1 GO:0050897 cobalt ion binding(GO:0050897)
0.0 0.2 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 0.2 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 0.1 GO:0004829 threonine-tRNA ligase activity(GO:0004829)
0.0 0.1 GO:0005152 interleukin-1 receptor antagonist activity(GO:0005152)
0.0 0.1 GO:0042577 lipid phosphatase activity(GO:0042577)
0.0 0.1 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.1 GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
0.0 0.1 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.0 0.0 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.0 0.1 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.0 0.0 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.0 0.1 GO:0003709 obsolete RNA polymerase III transcription factor activity(GO:0003709)
0.0 0.1 GO:0004470 malic enzyme activity(GO:0004470)
0.0 0.1 GO:0009374 biotin binding(GO:0009374)
0.0 0.1 GO:0071617 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) lysophosphatidic acid acyltransferase activity(GO:0042171) lysophospholipid acyltransferase activity(GO:0071617)
0.0 0.0 GO:0003829 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0003829)
0.0 0.1 GO:0004957 prostaglandin E receptor activity(GO:0004957)
0.0 0.1 GO:0016565 obsolete general transcriptional repressor activity(GO:0016565)
0.0 0.1 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0 0.1 GO:0042288 MHC class I protein binding(GO:0042288)
0.0 0.0 GO:0048495 Roundabout binding(GO:0048495)
0.0 0.0 GO:0030229 very-low-density lipoprotein particle receptor activity(GO:0030229)
0.0 0.1 GO:0048406 nerve growth factor binding(GO:0048406)
0.0 0.1 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 0.0 GO:0031705 bombesin receptor binding(GO:0031705) endothelin B receptor binding(GO:0031708)
0.0 0.0 GO:0004142 diacylglycerol cholinephosphotransferase activity(GO:0004142)
0.0 0.0 GO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.0 0.1 GO:0017025 TBP-class protein binding(GO:0017025)
0.0 0.0 GO:0008545 JUN kinase kinase activity(GO:0008545)
0.0 0.0 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0 0.0 GO:0043734 DNA demethylase activity(GO:0035514) DNA-N1-methyladenine dioxygenase activity(GO:0043734)
0.0 0.0 GO:0000268 peroxisome targeting sequence binding(GO:0000268)
0.0 0.0 GO:0032296 ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296)
0.0 0.1 GO:0070717 poly-purine tract binding(GO:0070717)
0.0 0.0 GO:0005294 neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.0 0.0 GO:0016215 stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215)
0.0 0.0 GO:0001515 opioid peptide activity(GO:0001515)
0.0 0.1 GO:0070087 chromo shadow domain binding(GO:0070087)
0.0 0.2 GO:0004532 exoribonuclease activity(GO:0004532)
0.0 0.1 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
0.0 0.1 GO:0003706 obsolete ligand-regulated transcription factor activity(GO:0003706)
0.0 0.0 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.0 0.0 GO:0003986 acetyl-CoA hydrolase activity(GO:0003986)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.0 ST GRANULE CELL SURVIVAL PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.0 0.0 PID TRAIL PATHWAY TRAIL signaling pathway
0.0 0.0 PID TXA2PATHWAY Thromboxane A2 receptor signaling
0.0 0.6 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 0.1 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 0.2 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.1 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.0 0.5 PID PS1 PATHWAY Presenilin action in Notch and Wnt signaling
0.0 0.2 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 0.0 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.0 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.4 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.0 0.7 REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0 0.2 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 0.0 REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS Genes involved in CREB phosphorylation through the activation of Ras
0.0 0.1 REACTOME PROSTANOID LIGAND RECEPTORS Genes involved in Prostanoid ligand receptors
0.0 0.3 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.1 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 0.0 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 0.1 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 0.1 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.0 0.1 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0 0.1 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL