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ENCODE: H3K4me1 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for NKX6-3

Z-value: 1.12

Motif logo

Transcription factors associated with NKX6-3

Gene Symbol	Gene ID	Gene Info
NKX6-3 Ensembl NCBI GeneCards UniProt	ENSG00000165066.11	NKX6-3

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
NKX6-3	chr8_41503976_41504252	764	0.539993	0.52	1.6e-01	Click!
NKX6-3	chr8_41512290_41512441	3510	0.156058	-0.51	1.6e-01	Click!
NKX6-3	chr8_41506141_41506292	1338	0.326383	-0.42	2.6e-01	Click!
NKX6-3	chr8_41503640_41503791	1163	0.373407	0.39	3.0e-01	Click!
NKX6-3	chr8_41503291_41503442	1512	0.291593	0.36	3.4e-01	Click!

Activity of the NKX6-3 motif across conditions

Conditions sorted by the z-value of the NKX6-3 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr11_33712841_33713004	1.02	RP4-541C22.5		5325	0.18
chr22_18539461_18539695	0.88	XXbac-B476C20.9		20985	0.13
chr11_102722401_102722552	0.83	MMP3	matrix metallopeptidase 3 (stromelysin 1, progelatinase)	7942	0.19
chr4_145504640_145504791	0.77	HHIP-AS1	HHIP antisense RNA 1	62349	0.14
chr9_14251921_14252072	0.73	NFIB	nuclear factor I/B	56016	0.15
chr6_114196551_114196945	0.73	MARCKS	myristoylated alanine-rich protein kinase C substrate	18207	0.17
chr6_52425530_52425681	0.66	TRAM2	translocation associated membrane protein 2	16108	0.24
chr1_206603221_206603372	0.61	SRGAP2	SLIT-ROBO Rho GTPase activating protein 2	20488	0.16
chr12_10545690_10545841	0.60	KLRK1	killer cell lectin-like receptor subfamily K, member 1	3148	0.16
chr2_225681896_225682047	0.58	DOCK10	dedicator of cytokinesis 10	602	0.85
chr10_65460709_65460902	0.58	REEP3	receptor accessory protein 3	179682	0.03
chr5_139626504_139626769	0.57	CTB-131B5.2		46888	0.09
chr17_61357894_61358045	0.57	RP11-269G24.2		32913	0.16
chr3_177651530_177651798	0.56	ENSG00000199858	.	73903	0.13
chr2_48571922_48572463	0.56	ENSG00000251889	.	4227	0.27
chr16_27590290_27590441	0.56	KIAA0556	KIAA0556	5137	0.22
chr5_16890159_16890310	0.55	MYO10	myosin X	26402	0.18
chr4_47215322_47215473	0.55	ENSG00000238301	.	92657	0.09
chr4_14728667_14728818	0.53	ENSG00000202449	.	36408	0.24
chr5_158370461_158370612	0.53	CTD-2363C16.1		39478	0.18
chr3_188995375_188995558	0.52	TPRG1-AS2	TPRG1 antisense RNA 2	37083	0.21
chr14_54405199_54405350	0.52	ENSG00000266431	.	9928	0.25
chr4_187608141_187608292	0.52	FAT1	FAT atypical cadherin 1	36793	0.2
chr5_64504974_64505125	0.51	ENSG00000207439	.	85853	0.1
chr7_72619380_72619686	0.51	NCF1B	neutrophil cytosolic factor 1B pseudogene	15078	0.17
chr4_125335710_125335861	0.51	ANKRD50	ankyrin repeat domain 50	298102	0.01
chr17_454384_454535	0.50	RP5-1029F21.2		1347	0.44
chr16_84765282_84765475	0.50	USP10	ubiquitin specific peptidase 10	31732	0.17
chr3_149298844_149298995	0.50	WWTR1	WW domain containing transcription regulator 1	4880	0.23
chr6_56591218_56591369	0.49	DST	dystonin	59384	0.15
chr6_44414403_44414554	0.49	ENSG00000266619	.	11100	0.18
chr6_158591128_158591427	0.48	GTF2H5	general transcription factor IIH, polypeptide 5	1893	0.27
chr2_150601107_150601258	0.48	ENSG00000207270	.	133894	0.05
chr22_33108393_33108637	0.48	LL22NC01-116C6.1		70648	0.1
chr11_111685692_111685843	0.48	ALG9-IT1	ALG9 intronic transcript 1 (non-protein coding)	14169	0.14
chr12_10344371_10344522	0.48	TMEM52B	transmembrane protein 52B	12333	0.12
chr1_246132469_246132620	0.47	RP11-83A16.1		64309	0.14
chr2_182941626_182941777	0.47	ENSG00000265129	.	11642	0.22
chr8_131156068_131156219	0.47	ENSG00000212342	.	19075	0.2
chr1_67397953_67399117	0.46	MIER1	mesoderm induction early response 1, transcriptional regulator	2609	0.29
chr8_126231993_126232161	0.46	ENSG00000242170	.	50769	0.15
chr2_217461850_217462001	0.46	AC073321.3		9736	0.19
chr10_28601668_28601819	0.46	ENSG00000222374	.	1961	0.37
chr4_170165351_170165677	0.44	SH3RF1	SH3 domain containing ring finger 1	25594	0.22
chr6_161590013_161590164	0.44	AGPAT4	1-acylglycerol-3-phosphate O-acyltransferase 4	19767	0.28
chr18_46056441_46056592	0.44	CTIF	CBP80/20-dependent translation initiation factor	8901	0.25
chr2_153441109_153441260	0.44	FMNL2	formin-like 2	34908	0.22
chr1_222341096_222341247	0.44	ENSG00000212094	.	154739	0.04
chr7_112636182_112636333	0.43	C7orf60	chromosome 7 open reading frame 60	56286	0.14
chr7_42233492_42233928	0.43	GLI3	GLI family zinc finger 3	33610	0.25
chr20_11120768_11120919	0.43	C20orf187	chromosome 20 open reading frame 187	112032	0.07
chr4_41150165_41150316	0.43	ENSG00000207198	.	34281	0.16
chr3_188067044_188067254	0.42	LPP	LIM domain containing preferred translocation partner in lipoma	109497	0.07
chr14_101459833_101459984	0.42	ENSG00000200089	.	335	0.31
chr4_141866091_141866242	0.42	RNF150	ring finger protein 150	52024	0.17
chr8_128755138_128755289	0.42	MYC	v-myc avian myelocytomatosis viral oncogene homolog	6736	0.28
chr4_186196562_186196713	0.42	SNX25	sorting nexin 25	65404	0.09
chr17_17640963_17641296	0.41	RAI1-AS1	RAI1 antisense RNA 1	33006	0.11
chr9_75764547_75765336	0.41	ANXA1	annexin A1	1732	0.5
chr13_43580173_43580324	0.41	EPSTI1	epithelial stromal interaction 1 (breast)	13863	0.24
chr12_27763041_27763300	0.40	PPFIBP1	PTPRF interacting protein, binding protein 1 (liprin beta 1)	10889	0.22
chr15_72045393_72045544	0.40	CTD-2524L6.3		65269	0.12
chr12_125160668_125160889	0.40	NCOR2	nuclear receptor corepressor 2	108768	0.07
chr2_46325558_46325709	0.40	AC017006.2		19666	0.24
chr10_71734773_71734924	0.40	COL13A1	collagen, type XIII, alpha 1	44639	0.15
chr8_58980536_58980687	0.40	FAM110B	family with sequence similarity 110, member B	73498	0.13
chr11_111848937_111849153	0.39	DIXDC1	DIX domain containing 1	1012	0.41
chr3_188104571_188104722	0.39	LPP	LIM domain containing preferred translocation partner in lipoma	146994	0.04
chr2_196547314_196547465	0.39	ENSG00000201813	.	12191	0.23
chr11_110228298_110228580	0.39	RDX	radixin	60992	0.14
chr6_79614930_79615081	0.39	IRAK1BP1	interleukin-1 receptor-associated kinase 1 binding protein 1	7096	0.29
chr2_55328902_55329053	0.38	ENSG00000266376	.	6869	0.2
chr12_89461977_89462128	0.38	ENSG00000238302	.	214010	0.02
chr12_94181628_94181779	0.38	ENSG00000264978	.	43149	0.13
chr6_139293869_139294337	0.38	REPS1	RALBP1 associated Eps domain containing 1	14674	0.24
chr11_60686848_60686999	0.38	TMEM109	transmembrane protein 109	227	0.84
chr4_7881276_7881455	0.38	AFAP1	actin filament associated protein 1	7325	0.25
chr7_116211652_116211947	0.38	AC006159.4		511	0.78
chr16_74514100_74514392	0.37	ENSG00000207525	.	16360	0.16
chr2_161608908_161609059	0.37	ENSG00000244372	.	125075	0.06
chr11_65047025_65047288	0.37	POLA2	polymerase (DNA directed), alpha 2, accessory subunit	2822	0.18
chr2_197264610_197264832	0.37	HECW2	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2	37775	0.2
chr6_108975764_108975915	0.37	FOXO3	forkhead box O3	1710	0.51
chr4_55408709_55408988	0.37	KIT	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	115237	0.07
chr7_129933263_129933414	0.36	CPA4	carboxypeptidase A4	219	0.91
chrX_39832066_39832217	0.36	BCOR	BCL6 corepressor	90049	0.09
chr11_126788305_126788456	0.36	KIRREL3-AS2	KIRREL3 antisense RNA 2	22262	0.2
chr8_143757168_143757384	0.36	PSCA	prostate stem cell antigen	4598	0.13
chr1_8138703_8138854	0.36	ERRFI1	ERBB receptor feedback inhibitor 1	52410	0.13
chr8_90739175_90739326	0.36	RIPK2	receptor-interacting serine-threonine kinase 2	30725	0.24
chr8_91783068_91783219	0.36	NECAB1	N-terminal EF-hand calcium binding protein 1	20635	0.19
chr3_182992678_182993398	0.35	B3GNT5	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5	9906	0.2
chr4_154388689_154389189	0.35	KIAA0922	KIAA0922	1438	0.51
chr3_197098695_197098846	0.35	ENSG00000238491	.	32348	0.17
chr2_47101079_47101246	0.35	AC016722.3		20527	0.13
chr5_95064137_95064401	0.35	RHOBTB3	Rho-related BTB domain containing 3	2307	0.25
chr2_36581626_36581777	0.35	CRIM1	cysteine rich transmembrane BMP regulator 1 (chordin-like)	1368	0.59
chr5_72327163_72327314	0.35	ENSG00000200833	.	68662	0.09
chr10_31604223_31604374	0.35	ENSG00000237036	.	3563	0.23
chr2_161232105_161232912	0.34	ENSG00000252465	.	20971	0.19
chr3_145882013_145882164	0.34	PLOD2	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2	648	0.77
chr10_89536127_89536278	0.34	ATAD1	ATPase family, AAA domain containing 1	16312	0.18
chr6_15095366_15095517	0.34	ENSG00000242989	.	17758	0.25
chr7_106873690_106873841	0.34	HBP1	HMG-box transcription factor 1	37472	0.15
chr8_53031421_53031572	0.34	RP11-26M5.3		31884	0.21
chr10_80832109_80832421	0.34	ZMIZ1	zinc finger, MIZ-type containing 1	3473	0.29
chr8_107951495_107951646	0.34	ABRA	actin-binding Rho activating protein	169097	0.04
chr7_116350835_116350986	0.34	MET	met proto-oncogene	11771	0.25
chr12_14990014_14990290	0.33	RP11-233G1.4		3874	0.14
chr7_36487948_36488099	0.33	AC006960.7		14609	0.19
chr8_38259724_38259888	0.33	RP11-350N15.3		605	0.59
chr18_73120073_73120224	0.33	RP11-321M21.3	HCG1996301; Uncharacterized protein	1181	0.58
chr11_131765892_131766043	0.33	AP004372.1		1035	0.61
chr5_142682227_142682378	0.33	ARHGAP26	Rho GTPase activating protein 26	95537	0.08
chr16_24742094_24743166	0.33	TNRC6A	trinucleotide repeat containing 6A	1596	0.5
chr1_198874035_198874197	0.33	ENSG00000207759	.	45834	0.17
chr4_26344038_26344485	0.33	RBPJ	recombination signal binding protein for immunoglobulin kappa J region	501	0.88
chr1_113666672_113666823	0.33	LRIG2	leucine-rich repeats and immunoglobulin-like domains 2	50916	0.17
chr9_80078507_80078658	0.33	RP11-466A17.1		7371	0.28
chr20_45905361_45905512	0.33	ZMYND8	zinc finger, MYND-type containing 8	22208	0.14
chr2_218258772_218258923	0.33	ENSG00000251982	.	142568	0.05
chr1_172855064_172855215	0.33	TNFSF18	tumor necrosis factor (ligand) superfamily, member 18	164917	0.04
chr6_117769723_117769874	0.32	ENSG00000221434	.	3245	0.19
chr4_170081579_170081730	0.32	RP11-327O17.2		41291	0.18
chr6_21004450_21004601	0.32	ENSG00000252046	.	10726	0.32
chr14_52795656_52796058	0.32	PTGER2	prostaglandin E receptor 2 (subtype EP2), 53kDa	14744	0.25
chr3_150422131_150422452	0.32	RP11-103G8.2		461	0.51
chr10_29772721_29772872	0.32	SVIL	supervillin	12651	0.23
chr11_28855936_28856087	0.32	ENSG00000211499	.	442225	0.01
chr2_142315504_142315655	0.32	ENSG00000265224	.	80834	0.12
chr16_81638343_81638641	0.32	CMIP	c-Maf inducing protein	40471	0.2
chr10_62187776_62187927	0.31	ANK3	ankyrin 3, node of Ranvier (ankyrin G)	38363	0.23
chr2_56181551_56181702	0.31	ENSG00000202344	.	2477	0.26
chr6_38228109_38228260	0.31	ENSG00000200706	.	53134	0.16
chr4_184558434_184558585	0.31	ENSG00000252157	.	16320	0.14
chr3_45521464_45521615	0.31	LARS2-AS1	LARS2 antisense RNA 1	29498	0.2
chr3_136505593_136506225	0.31	SLC35G2	solute carrier family 35, member G2	31952	0.12
chr17_39218871_39219022	0.31	KRTAP2-3	keratin associated protein 2-3	2602	0.09
chr18_67711328_67711479	0.30	RTTN	rotatin	23449	0.25
chr8_77711424_77711575	0.30	ZFHX4	zinc finger homeobox 4	95219	0.08
chr12_66345138_66345289	0.30	RP11-366L20.3		2954	0.27
chr2_43986548_43986990	0.30	ENSG00000252490	.	12720	0.19
chr14_90557642_90557793	0.30	KCNK13	potassium channel, subfamily K, member 13	29608	0.2
chr11_20505330_20505481	0.30	PRMT3	protein arginine methyltransferase 3	96143	0.08
chr4_15013014_15013165	0.30	CPEB2	cytoplasmic polyadenylation element binding protein 2	7529	0.3
chr1_25666704_25667414	0.30	ENSG00000252515	.	403	0.75
chr5_57485225_57485376	0.30	ENSG00000238899	.	119285	0.06
chr12_65288524_65288675	0.30	ENSG00000221564	.	44204	0.15
chr1_61989098_61989249	0.30	ENSG00000264551	.	105530	0.07
chr4_183161080_183161231	0.30	TENM3	teneurin transmembrane protein 3	3427	0.32
chrX_41135797_41136128	0.30	ENSG00000199564	.	16089	0.18
chr9_117877775_117877926	0.30	TNC	tenascin C	2628	0.36
chr11_74659216_74659741	0.30	XRRA1	X-ray radiation resistance associated 1	587	0.48
chr10_62570411_62570562	0.30	CDK1	cyclin-dependent kinase 1	30575	0.22
chr1_198226866_198227037	0.30	NEK7	NIMA-related kinase 7	37022	0.23
chr2_145088605_145089481	0.30	GTDC1	glycosyltransferase-like domain containing 1	1040	0.68
chr1_198238756_198238907	0.30	NEK7	NIMA-related kinase 7	48902	0.19
chr13_51104174_51104472	0.29	ENSG00000221198	.	166950	0.04
chr15_45881879_45882313	0.29	BLOC1S6	biogenesis of lysosomal organelles complex-1, subunit 6, pallidin	2073	0.2
chr1_165739030_165739243	0.29	TMCO1	transmembrane and coiled-coil domains 1	719	0.5
chr7_13985521_13985672	0.29	ETV1	ets variant 1	40470	0.2
chr15_38690005_38690267	0.29	FAM98B	family with sequence similarity 98, member B	56192	0.14
chr2_9171149_9171380	0.29	MBOAT2	membrane bound O-acyltransferase domain containing 2	27322	0.22
chr3_149189968_149190119	0.29	TM4SF4	transmembrane 4 L six family member 4	1718	0.4
chr12_67665547_67665828	0.29	CAND1	cullin-associated and neddylation-dissociated 1	2006	0.5
chr18_43819137_43819353	0.29	C18orf25	chromosome 18 open reading frame 25	65245	0.11
chr7_137534903_137535054	0.29	DGKI	diacylglycerol kinase, iota	3140	0.34
chr6_111273369_111273520	0.29	GTF3C6	general transcription factor IIIC, polypeptide 6, alpha 35kDa	6319	0.15
chr4_24069141_24069414	0.29	PPARGC1A	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	177577	0.03
chr4_138974616_138974767	0.29	ENSG00000250033	.	3927	0.38
chr3_151985241_151985971	0.29	MBNL1	muscleblind-like splicing regulator 1	223	0.93
chr2_225027538_225027689	0.29	ENSG00000211987	.	76660	0.11
chr14_80052151_80052302	0.29	RP11-242P2.2		47428	0.2
chr1_179148045_179148196	0.29	ENSG00000212338	.	17488	0.17
chr4_138975505_138975656	0.28	ENSG00000250033	.	3038	0.41
chr21_28941972_28942234	0.28	ADAMTS5	ADAM metallopeptidase with thrombospondin type 1 motif, 5	603271	0.0
chr2_179070454_179070605	0.28	OSBPL6	oxysterol binding protein-like 6	11153	0.22
chr9_89952372_89952738	0.28	ENSG00000212421	.	77190	0.11
chr10_15368183_15368334	0.28	FAM171A1	family with sequence similarity 171, member A1	44800	0.17
chr20_37614000_37614151	0.28	DHX35	DEAH (Asp-Glu-Ala-His) box polypeptide 35	23088	0.18
chr8_29109260_29109557	0.28	KIF13B	kinesin family member 13B	11182	0.17
chr8_25032357_25032508	0.28	ENSG00000241811	.	6803	0.25
chr5_64459127_64459278	0.28	ENSG00000207439	.	40006	0.22
chr10_95235571_95235788	0.28	MYOF	myoferlin	6272	0.2
chr2_100218822_100218973	0.28	AFF3	AF4/FMR2 family, member 3	24065	0.23
chr21_40683413_40684326	0.28	BRWD1	bromodomain and WD repeat domain containing 1	1627	0.24
chr5_92694884_92695035	0.28	ENSG00000237187	.	63160	0.15
chr8_128937773_128937924	0.28	TMEM75	transmembrane protein 75	22743	0.19
chr2_1657675_1657826	0.28	AC144450.1		33865	0.19
chr5_154158547_154158698	0.28	LARP1	La ribonucleoprotein domain family, member 1	13671	0.17
chr3_142719040_142719191	0.28	U2SURP	U2 snRNP-associated SURP domain containing	1251	0.46
chr1_150450551_150450702	0.28	TARS2	threonyl-tRNA synthetase 2, mitochondrial (putative)	9261	0.13
chr10_59788519_59788670	0.28	ENSG00000238970	.	209927	0.02
chr1_61918584_61919140	0.28	NFIA	nuclear factor I/A	46518	0.19
chr5_92353866_92354017	0.28	ENSG00000221810	.	300721	0.01
chr5_76134379_76134541	0.28	ENSG00000264391	.	1440	0.37
chr16_58597342_58597493	0.28	ENSG00000206952	.	3582	0.17
chr18_30492153_30492304	0.27	RP11-680N20.1		41811	0.18
chr1_76231815_76231966	0.27	RABGGTB	Rab geranylgeranyltransferase, beta subunit	19989	0.11
chr12_10544948_10545233	0.27	KLRK1	killer cell lectin-like receptor subfamily K, member 1	2473	0.19

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX6-3

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0007221	positive regulation of transcription of Notch receptor target(GO:0007221)
0.1	0.2	GO:0060831	smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:0060831)
0.1	0.2	GO:1901722	regulation of cell proliferation involved in kidney development(GO:1901722)
0.0	0.2	GO:0031340	positive regulation of vesicle fusion(GO:0031340)
0.0	0.1	GO:0010757	negative regulation of plasminogen activation(GO:0010757)
0.0	0.2	GO:0007171	activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.0	0.1	GO:0010837	regulation of keratinocyte proliferation(GO:0010837)
0.0	0.2	GO:0007256	activation of JNKK activity(GO:0007256)
0.0	0.1	GO:0045046	protein import into peroxisome membrane(GO:0045046)
0.0	0.1	GO:0071481	cellular response to X-ray(GO:0071481)
0.0	0.2	GO:0001547	antral ovarian follicle growth(GO:0001547)
0.0	0.1	GO:0010761	fibroblast migration(GO:0010761)
0.0	0.1	GO:0045898	regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0	0.1	GO:0048312	intracellular distribution of mitochondria(GO:0048312)
0.0	0.1	GO:0050774	negative regulation of dendrite morphogenesis(GO:0050774)
0.0	0.2	GO:0060390	regulation of SMAD protein import into nucleus(GO:0060390)
0.0	0.1	GO:0007144	female meiosis I(GO:0007144)
0.0	0.1	GO:0006166	purine ribonucleoside salvage(GO:0006166)
0.0	0.1	GO:0015825	L-serine transport(GO:0015825)
0.0	0.1	GO:0007028	cytoplasm organization(GO:0007028)
0.0	0.1	GO:0072385	minus-end-directed organelle transport along microtubule(GO:0072385)
0.0	0.0	GO:0060686	negative regulation of prostatic bud formation(GO:0060686)
0.0	0.0	GO:0071504	cellular response to heparin(GO:0071504)
0.0	0.1	GO:0042797	5S class rRNA transcription from RNA polymerase III type 1 promoter(GO:0042791) tRNA transcription from RNA polymerase III promoter(GO:0042797)
0.0	0.2	GO:0009886	post-embryonic morphogenesis(GO:0009886)
0.0	0.0	GO:0090081	regulation of heart induction by regulation of canonical Wnt signaling pathway(GO:0090081)
0.0	0.2	GO:0097354	protein prenylation(GO:0018342) prenylation(GO:0097354)
0.0	0.1	GO:0046719	intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) regulation by virus of viral protein levels in host cell(GO:0046719) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708)
0.0	0.2	GO:0006896	Golgi to endosome transport(GO:0006895) Golgi to vacuole transport(GO:0006896)
0.0	0.0	GO:0051988	regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.0	0.1	GO:0001778	plasma membrane repair(GO:0001778)
0.0	0.0	GO:0072112	renal filtration cell differentiation(GO:0061318) glomerular epithelium development(GO:0072010) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.0	0.1	GO:0010842	retina layer formation(GO:0010842)
0.0	0.1	GO:0043589	skin morphogenesis(GO:0043589)
0.0	0.1	GO:0007412	axon target recognition(GO:0007412)
0.0	0.0	GO:0051771	negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771)
0.0	0.1	GO:0010566	regulation of ketone biosynthetic process(GO:0010566) regulation of aldosterone metabolic process(GO:0032344) regulation of aldosterone biosynthetic process(GO:0032347)
0.0	0.1	GO:0034695	response to prostaglandin E(GO:0034695)
0.0	0.0	GO:0035385	Roundabout signaling pathway(GO:0035385)
0.0	0.1	GO:0007185	transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0	0.1	GO:0051305	chromosome movement towards spindle pole(GO:0051305)
0.0	0.4	GO:0030574	collagen catabolic process(GO:0030574)
0.0	0.0	GO:0070208	protein heterotrimerization(GO:0070208)
0.0	0.1	GO:0031657	regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle(GO:0031657) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle(GO:0031659)
0.0	0.1	GO:0070254	mucus secretion(GO:0070254)
0.0	0.1	GO:0060638	mesenchymal-epithelial cell signaling(GO:0060638)
0.0	0.0	GO:0021834	chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration(GO:0021834)
0.0	0.0	GO:0061302	smooth muscle cell-matrix adhesion(GO:0061302)
0.0	0.3	GO:1905037	autophagosome assembly(GO:0000045) autophagosome organization(GO:1905037)
0.0	0.1	GO:0048755	branching morphogenesis of a nerve(GO:0048755)
0.0	0.1	GO:0006435	threonyl-tRNA aminoacylation(GO:0006435)
0.0	0.1	GO:0009649	entrainment of circadian clock(GO:0009649)
0.0	0.1	GO:0060039	pericardium development(GO:0060039)
0.0	0.1	GO:0048149	behavioral response to ethanol(GO:0048149)
0.0	0.1	GO:0060040	retinal bipolar neuron differentiation(GO:0060040)
0.0	0.0	GO:0060235	lens induction in camera-type eye(GO:0060235)
0.0	0.4	GO:0048009	insulin-like growth factor receptor signaling pathway(GO:0048009)
0.0	0.1	GO:0006516	glycoprotein catabolic process(GO:0006516)
0.0	0.0	GO:0070050	neuron cellular homeostasis(GO:0070050)
0.0	0.0	GO:0001672	regulation of chromatin assembly or disassembly(GO:0001672)
0.0	0.0	GO:0060789	hair follicle placode formation(GO:0060789)
0.0	0.0	GO:0060648	mammary gland bud morphogenesis(GO:0060648)
0.0	0.0	GO:0035426	extracellular matrix-cell signaling(GO:0035426)
0.0	0.0	GO:0048702	embryonic neurocranium morphogenesis(GO:0048702)
0.0	0.1	GO:0034501	protein localization to kinetochore(GO:0034501)
0.0	0.1	GO:0044314	protein K27-linked ubiquitination(GO:0044314)
0.0	0.1	GO:0007386	compartment pattern specification(GO:0007386)
0.0	0.0	GO:0032928	regulation of superoxide anion generation(GO:0032928)
0.0	0.0	GO:0015864	pyrimidine nucleoside transport(GO:0015864)
0.0	0.0	GO:0002541	activation of plasma proteins involved in acute inflammatory response(GO:0002541)
0.0	0.0	GO:0031536	positive regulation of exit from mitosis(GO:0031536)
0.0	0.1	GO:0001945	lymph vessel development(GO:0001945)
0.0	0.1	GO:0033261	obsolete regulation of S phase(GO:0033261)
0.0	0.0	GO:0016999	antibiotic metabolic process(GO:0016999) antibiotic biosynthetic process(GO:0017000)
0.0	0.1	GO:0006432	phenylalanyl-tRNA aminoacylation(GO:0006432)
0.0	0.1	GO:1901339	activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0	0.0	GO:0030505	inorganic diphosphate transport(GO:0030505)
0.0	0.1	GO:0000729	DNA double-strand break processing(GO:0000729)
0.0	0.0	GO:0014012	peripheral nervous system axon regeneration(GO:0014012)
0.0	0.0	GO:0002220	innate immune response activating cell surface receptor signaling pathway(GO:0002220)
0.0	0.2	GO:0032964	collagen biosynthetic process(GO:0032964)
0.0	0.0	GO:0008354	germ cell migration(GO:0008354)
0.0	0.0	GO:0070561	vitamin D receptor signaling pathway(GO:0070561)
0.0	0.0	GO:0000103	sulfate assimilation(GO:0000103)
0.0	0.0	GO:0033600	negative regulation of mammary gland epithelial cell proliferation(GO:0033600)
0.0	0.0	GO:0035511	oxidative DNA demethylation(GO:0035511)
0.0	0.0	GO:0034629	cellular protein complex localization(GO:0034629)
0.0	0.1	GO:0010700	negative regulation of norepinephrine secretion(GO:0010700)
0.0	0.0	GO:0006564	L-serine biosynthetic process(GO:0006564)
0.0	0.1	GO:0000381	regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0	0.2	GO:0043631	RNA polyadenylation(GO:0043631)
0.0	0.1	GO:0006853	carnitine shuttle(GO:0006853) carnitine transmembrane transport(GO:1902603)
0.0	0.2	GO:0030199	collagen fibril organization(GO:0030199)
0.0	0.1	GO:0072665	protein targeting to lysosome(GO:0006622) protein targeting to vacuole(GO:0006623) protein localization to lysosome(GO:0061462) protein localization to vacuole(GO:0072665) establishment of protein localization to vacuole(GO:0072666)
0.0	0.0	GO:0060242	contact inhibition(GO:0060242)
0.0	0.0	GO:0010966	regulation of phosphate transport(GO:0010966)
0.0	0.0	GO:0060457	negative regulation of digestive system process(GO:0060457)
0.0	0.0	GO:0043985	histone H4-R3 methylation(GO:0043985)
0.0	0.2	GO:0035195	gene silencing by miRNA(GO:0035195)

Gene overrepresentation in cellular component category:

Total log-likelihood	Term	Description
0.1	GO:0032045	guanyl-nucleotide exchange factor complex(GO:0032045)
0.1	GO:0030934	anchoring collagen complex(GO:0030934)
0.1	GO:0031618	nuclear pericentric heterochromatin(GO:0031618)
0.1	GO:0034673	inhibin-betaglycan-ActRII complex(GO:0034673)
0.1	GO:0031362	anchored component of external side of plasma membrane(GO:0031362)
0.1	GO:0005787	signal peptidase complex(GO:0005787)
0.1	GO:0005954	calcium- and calmodulin-dependent protein kinase complex(GO:0005954)
0.2	GO:0030990	intraciliary transport particle(GO:0030990)
0.1	GO:0043656	host(GO:0018995) host cell part(GO:0033643) host intracellular part(GO:0033646) intracellular region of host(GO:0043656) host cell(GO:0043657) other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217)
0.1	GO:0000127	transcription factor TFIIIC complex(GO:0000127)
0.1	GO:0031588	nucleotide-activated protein kinase complex(GO:0031588)
0.1	GO:1990316	ATG1/ULK1 kinase complex(GO:1990316)
0.1	GO:0032444	activin responsive factor complex(GO:0032444)
0.1	GO:0005945	6-phosphofructokinase complex(GO:0005945)
0.1	GO:0030056	hemidesmosome(GO:0030056)
0.1	GO:0005641	nuclear envelope lumen(GO:0005641)
0.2	GO:0030867	rough endoplasmic reticulum membrane(GO:0030867)
0.1	GO:0031232	extrinsic component of external side of plasma membrane(GO:0031232)
0.0	GO:0071942	XPC complex(GO:0071942)
0.0	GO:0071778	obsolete WINAC complex(GO:0071778)
0.1	GO:0033268	node of Ranvier(GO:0033268)
0.1	GO:0002102	podosome(GO:0002102)
0.1	GO:0005916	fascia adherens(GO:0005916)
0.1	GO:0000015	phosphopyruvate hydratase complex(GO:0000015)
0.3	GO:0033017	sarcoplasmic reticulum membrane(GO:0033017)
0.1	GO:0016600	flotillin complex(GO:0016600)
0.3	GO:0001533	cornified envelope(GO:0001533)
0.0	GO:0032133	chromosome passenger complex(GO:0032133)
0.1	GO:0000796	condensin complex(GO:0000796)
0.0	GO:0001740	Barr body(GO:0001740)
0.1	GO:0030122	AP-2 adaptor complex(GO:0030122) clathrin coat of endocytic vesicle(GO:0030128)
0.0	GO:0070552	BRISC complex(GO:0070552)
0.1	GO:0071564	npBAF complex(GO:0071564)
0.1	GO:0010494	cytoplasmic stress granule(GO:0010494)
0.1	GO:0005614	interstitial matrix(GO:0005614)
0.1	GO:0031010	ISWI-type complex(GO:0031010)
0.0	GO:0042272	nuclear RNA export factor complex(GO:0042272)
0.4	GO:0017053	transcriptional repressor complex(GO:0017053)
0.0	GO:0072669	tRNA-splicing ligase complex(GO:0072669)
0.1	GO:0017146	NMDA selective glutamate receptor complex(GO:0017146)
0.1	GO:0016272	prefoldin complex(GO:0016272)
0.0	GO:0005826	actomyosin contractile ring(GO:0005826)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0005010	insulin-like growth factor-activated receptor activity(GO:0005010)
0.1	0.3	GO:0008475	procollagen-lysine 5-dioxygenase activity(GO:0008475)
0.1	0.2	GO:0019834	phospholipase A2 inhibitor activity(GO:0019834)
0.1	0.2	GO:0005173	stem cell factor receptor binding(GO:0005173)
0.0	0.1	GO:0017162	aryl hydrocarbon receptor binding(GO:0017162)
0.0	0.1	GO:0016901	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor(GO:0016901)
0.0	0.1	GO:0045545	syndecan binding(GO:0045545)
0.0	0.2	GO:0004862	cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0	0.1	GO:0032794	GTPase activating protein binding(GO:0032794)
0.0	0.1	GO:0050501	hyaluronan synthase activity(GO:0050501)
0.0	0.1	GO:0030297	transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.0	0.1	GO:0005078	MAP-kinase scaffold activity(GO:0005078)
0.0	0.1	GO:0015194	L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.0	0.1	GO:0070700	BMP receptor binding(GO:0070700)
0.0	0.1	GO:0008321	Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0	0.3	GO:0051010	microtubule plus-end binding(GO:0051010)
0.0	0.1	GO:0004904	interferon receptor activity(GO:0004904)
0.0	0.1	GO:0002162	dystroglycan binding(GO:0002162)
0.0	0.1	GO:0005006	epidermal growth factor-activated receptor activity(GO:0005006)
0.0	0.2	GO:0005114	type II transforming growth factor beta receptor binding(GO:0005114)
0.0	0.1	GO:0017112	Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0	0.5	GO:0004181	metallocarboxypeptidase activity(GO:0004181)
0.0	0.1	GO:0047115	trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity(GO:0047115)
0.0	0.8	GO:0017048	Rho GTPase binding(GO:0017048)
0.0	0.1	GO:0003872	6-phosphofructokinase activity(GO:0003872)
0.0	0.1	GO:0004157	dihydropyrimidinase activity(GO:0004157)
0.0	0.1	GO:0050998	nitric-oxide synthase binding(GO:0050998)
0.0	0.1	GO:0030020	extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.0	0.1	GO:0031994	insulin-like growth factor I binding(GO:0031994)
0.0	0.1	GO:0008318	protein prenyltransferase activity(GO:0008318)
0.0	0.1	GO:0050508	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.0	0.1	GO:0070576	vitamin D 24-hydroxylase activity(GO:0070576)
0.0	0.1	GO:0008384	IkappaB kinase activity(GO:0008384)
0.0	0.1	GO:0050897	cobalt ion binding(GO:0050897)
0.0	0.2	GO:0004143	diacylglycerol kinase activity(GO:0004143)
0.0	0.2	GO:0035035	histone acetyltransferase binding(GO:0035035)
0.0	0.1	GO:0004829	threonine-tRNA ligase activity(GO:0004829)
0.0	0.1	GO:0005152	interleukin-1 receptor antagonist activity(GO:0005152)
0.0	0.1	GO:0042577	lipid phosphatase activity(GO:0042577)
0.0	0.1	GO:0035259	glucocorticoid receptor binding(GO:0035259)
0.0	0.1	GO:0003956	NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
0.0	0.1	GO:0048027	mRNA 5'-UTR binding(GO:0048027)
0.0	0.0	GO:0051371	muscle alpha-actinin binding(GO:0051371)
0.0	0.1	GO:0004634	phosphopyruvate hydratase activity(GO:0004634)
0.0	0.0	GO:0004720	protein-lysine 6-oxidase activity(GO:0004720)
0.0	0.1	GO:0003709	obsolete RNA polymerase III transcription factor activity(GO:0003709)
0.0	0.1	GO:0004470	malic enzyme activity(GO:0004470)
0.0	0.1	GO:0009374	biotin binding(GO:0009374)
0.0	0.1	GO:0071617	1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) lysophosphatidic acid acyltransferase activity(GO:0042171) lysophospholipid acyltransferase activity(GO:0071617)
0.0	0.0	GO:0003829	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0003829)
0.0	0.1	GO:0004957	prostaglandin E receptor activity(GO:0004957)
0.0	0.1	GO:0016565	obsolete general transcriptional repressor activity(GO:0016565)
0.0	0.1	GO:0030618	transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0	0.1	GO:0042288	MHC class I protein binding(GO:0042288)
0.0	0.0	GO:0048495	Roundabout binding(GO:0048495)
0.0	0.0	GO:0030229	very-low-density lipoprotein particle receptor activity(GO:0030229)
0.0	0.1	GO:0048406	nerve growth factor binding(GO:0048406)
0.0	0.1	GO:0070577	lysine-acetylated histone binding(GO:0070577)
0.0	0.0	GO:0031705	bombesin receptor binding(GO:0031705) endothelin B receptor binding(GO:0031708)
0.0	0.0	GO:0004142	diacylglycerol cholinephosphotransferase activity(GO:0004142)
0.0	0.0	GO:0003918	DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.0	0.1	GO:0017025	TBP-class protein binding(GO:0017025)
0.0	0.0	GO:0008545	JUN kinase kinase activity(GO:0008545)
0.0	0.0	GO:0015016	[heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0	0.0	GO:0043734	DNA demethylase activity(GO:0035514) DNA-N1-methyladenine dioxygenase activity(GO:0043734)
0.0	0.0	GO:0000268	peroxisome targeting sequence binding(GO:0000268)
0.0	0.0	GO:0032296	ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296)
0.0	0.1	GO:0070717	poly-purine tract binding(GO:0070717)
0.0	0.0	GO:0005294	neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.0	0.0	GO:0016215	stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215)
0.0	0.0	GO:0001515	opioid peptide activity(GO:0001515)
0.0	0.1	GO:0070087	chromo shadow domain binding(GO:0070087)
0.0	0.2	GO:0004532	exoribonuclease activity(GO:0004532)
0.0	0.1	GO:0004826	phenylalanine-tRNA ligase activity(GO:0004826)
0.0	0.1	GO:0003706	obsolete ligand-regulated transcription factor activity(GO:0003706)
0.0	0.0	GO:0016941	natriuretic peptide receptor activity(GO:0016941)
0.0	0.0	GO:0003986	acetyl-CoA hydrolase activity(GO:0003986)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.0	ST GRANULE CELL SURVIVAL PATHWAY	Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.0	PID TRAIL PATHWAY	TRAIL signaling pathway
0.0	PID TXA2PATHWAY	Thromboxane A2 receptor signaling
0.6	PID CDC42 REG PATHWAY	Regulation of CDC42 activity
0.1	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.2	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1	PID RAC1 REG PATHWAY	Regulation of RAC1 activity
0.5	PID PS1 PATHWAY	Presenilin action in Notch and Wnt signaling
0.2	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.0	SA PROGRAMMED CELL DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.0	REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.4	REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	Genes involved in DCC mediated attractive signaling
0.7	REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION	Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.2	REACTOME NOTCH HLH TRANSCRIPTION PATHWAY	Genes involved in Notch-HLH transcription pathway
0.0	REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS	Genes involved in CREB phosphorylation through the activation of Ras
0.1	REACTOME PROSTANOID LIGAND RECEPTORS	Genes involved in Prostanoid ligand receptors
0.3	REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX	Genes involved in Degradation of the extracellular matrix
0.1	REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK	Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0	REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.1	REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING	Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.1	REACTOME NEPHRIN INTERACTIONS	Genes involved in Nephrin interactions
0.1	REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE	Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.1	REACTOME SIGNALING BY NODAL	Genes involved in Signaling by NODAL