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ENCODE: H3K4me1 ChIP-Seq of primary human cells
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Results for NR1D1

Z-value: 0.99

Motif logo

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Transcription factors associated with NR1D1

Gene Symbol Gene ID Gene Info
NR1D1
ENSG00000126368.5 nuclear receptor subfamily 1 group D member 1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr17_38267210_38267680NR1D1104670.111988-0.872.5e-03Click!
chr17_38256127_38256278NR1D17760.511252-0.844.2e-03Click!
chr17_38267680_38267831NR1D1107770.111446-0.835.9e-03Click!
chr17_38257796_38257963NR1D19010.448949-0.827.1e-03Click!
chr17_38263559_38264452NR1D170270.119812-0.722.7e-02Click!

Activity of the NR1D1 motif across conditions

Conditions sorted by the z-value of the NR1D1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr20_62240080_62240231 0.70 GMEB2
 glucocorticoid modulatory element binding protein 2
 3900
 0.13
chr16_16168105_16168644 0.49 ABCC1
 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
 64661
 0.11
chr11_48057502_48058059 0.47 AC103828.1
20373
 0.19
chr7_508753_509105 0.44 PDGFA
 platelet-derived growth factor alpha polypeptide
 49216
 0.14
chr3_98275754_98275968 0.43 GPR15
 G protein-coupled receptor 15
 25118
 0.13
chr20_62240442_62240593 0.43 GMEB2
 glucocorticoid modulatory element binding protein 2
 4262
 0.12
chr1_206751930_206752246 0.41 RASSF5
 Ras association (RalGDS/AF-6) domain family member 5
 21595
 0.14
chr22_30679087_30679350 0.41 GATSL3
 GATS protein-like 3
 6378
 0.1
chrX_54442126_54442496 0.41 TSR2
 TSR2, 20S rRNA accumulation, homolog (S. cerevisiae)
 24523
 0.19
chr9_140215104_140215809 0.41 NRARP
 NOTCH-regulated ankyrin repeat protein
 18753
 0.09
chr16_56999551_56999979 0.41 CETP
 cholesteryl ester transfer protein, plasma
 3746
 0.14
chr11_47433734_47434023 0.37 SLC39A13
 solute carrier family 39 (zinc transporter), member 13
 2242
 0.14
chr11_326945_327265 0.36 IFITM3
 interferon induced transmembrane protein 3
 432
 0.62
chr20_62241205_62241356 0.36 GMEB2
 glucocorticoid modulatory element binding protein 2
 5025
 0.12
chr19_13204892_13205479 0.34 LYL1
 lymphoblastic leukemia derived sequence 1
 8496
 0.1
chr2_113930541_113930896 0.32 PSD4
 pleckstrin and Sec7 domain containing 4
 830
 0.5
chr11_73086432_73086886 0.32 RELT
 RELT tumor necrosis factor receptor
 650
 0.64
chr9_92055035_92055186 0.32 SEMA4D
 sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
 3712
 0.3
chr15_76023964_76024375 0.32 AC019294.1
6142
 0.1
chr2_114662697_114662848 0.31 ACTR3
 ARP3 actin-related protein 3 homolog (yeast)
 14597
 0.22
chr2_19105837_19105988 0.31 NT5C1B
 5'-nucleotidase, cytosolic IB
 335074
 0.01
chr5_169058393_169058544 0.31 DOCK2
 dedicator of cytokinesis 2
 5783
 0.26
chr4_6930967_6931437 0.30 TBC1D14
 TBC1 domain family, member 14
 19227
 0.15
chr21_47972385_47972571 0.30 ENSG00000272283
 .
 16769
 0.17
chr12_12628244_12628725 0.30 DUSP16
 dual specificity phosphatase 16
 45575
 0.15
chr3_71573965_71574178 0.30 ENSG00000221264
 .
 17169
 0.2
chr1_153514792_153515209 0.30 S100A5
 S100 calcium binding protein A5
 759
 0.41
chr1_59407152_59407509 0.29 JUN
 jun proto-oncogene
 157545
 0.04
chr2_219676341_219676492 0.29 CYP27A1
 cytochrome P450, family 27, subfamily A, polypeptide 1
 5779
 0.15
chr12_6557124_6557320 0.29 CD27
 CD27 molecule
 3189
 0.12
chr5_67515227_67515407 0.29 PIK3R1
 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
 3713
 0.29
chr14_51574865_51575105 0.28 TRIM9
 tripartite motif containing 9
 12206
 0.21
chr18_13438233_13438460 0.28 LDLRAD4-AS1
 LDLRAD4 antisense RNA 1
 10867
 0.12
chr4_177756596_177756747 0.28 VEGFC
 vascular endothelial growth factor C
 42790
 0.21
chr5_32838212_32838391 0.28 AC026703.1
49356
 0.16
chr16_29212717_29212868 0.28 CTB-134H23.3
94026
 0.05
chr19_54874397_54874958 0.28 LAIR1
 leukocyte-associated immunoglobulin-like receptor 1
 1737
 0.22
chr10_89953557_89953785 0.28 ENSG00000200891
 .
 199219
 0.03
chr6_112362238_112362440 0.28 WISP3
 WNT1 inducible signaling pathway protein 3
 12936
 0.2
chr11_60859183_60859572 0.28 CD5
 CD5 molecule
 10490
 0.18
chr4_2299878_2300029 0.27 RP11-478C1.7
2642
 0.2
chr22_38850403_38851076 0.27 KCNJ4
 potassium inwardly-rectifying channel, subfamily J, member 4
 466
 0.74
chr10_105671782_105672044 0.27 OBFC1
 oligonucleotide/oligosaccharide-binding fold containing 1
 5514
 0.19
chr1_160635144_160635480 0.27 RP11-404F10.2
5256
 0.17
chr1_198632560_198632794 0.27 RP11-553K8.5
3513
 0.3
chr17_57442951_57443122 0.27 ENSG00000263857
 .
 408
 0.84
chr4_3204868_3205180 0.27 MSANTD1
 Myb/SANT-like DNA-binding domain containing 1
 41072
 0.15
chr8_144489216_144489574 0.27 RP11-909N17.2
5524
 0.11
chr9_92054735_92055023 0.27 SEMA4D
 sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
 3481
 0.31
chr14_98689187_98689819 0.27 ENSG00000222066
 .
 108584
 0.07
chr12_49371240_49371781 0.26 WNT1
 wingless-type MMTV integration site family, member 1
 888
 0.29
chr19_55016899_55017050 0.26 LAIR2
 leukocyte-associated immunoglobulin-like receptor 2
 2851
 0.15
chr17_75876491_75876757 0.26 FLJ45079
2035
 0.39
chr6_157388395_157388707 0.26 RP1-137K2.2
52289
 0.17
chr11_117844189_117844444 0.26 IL10RA
 interleukin 10 receptor, alpha
 12747
 0.18
chr21_46390444_46390672 0.26 FAM207A
 family with sequence similarity 207, member A
 30618
 0.1
chr19_18722693_18723176 0.26 TMEM59L
 transmembrane protein 59-like
 748
 0.45
chr16_66524550_66524737 0.26 AC132186.1
 CDNA FLJ27243 fis, clone SYN08134; Uncharacterized protein
 4896
 0.13
chr5_149464844_149464995 0.26 CSF1R
 colony stimulating factor 1 receptor
 1071
 0.46
chr5_139049687_139050600 0.26 CXXC5
 CXXC finger protein 5
 4878
 0.24
chr5_148746761_148747114 0.26 RP11-394O4.3
4800
 0.13
chr14_55222326_55222477 0.26 SAMD4A
 sterile alpha motif domain containing 4A
 850
 0.72
chr22_24829765_24830186 0.26 ADORA2A
 adenosine A2a receptor
 1167
 0.48
chr4_129405273_129405424 0.26 PGRMC2
 progesterone receptor membrane component 2
 195364
 0.03
chr8_122001527_122001678 0.25 ENSG00000252093
 .
 80026
 0.11
chr17_38495361_38495755 0.25 RARA
 retinoic acid receptor, alpha
 2082
 0.19
chr1_167442877_167443113 0.25 RP11-104L21.2
15097
 0.2
chr5_148884105_148884256 0.25 CSNK1A1
 casein kinase 1, alpha 1
 8540
 0.18
chr19_1396678_1396882 0.25 AC005329.7
314
 0.74
chr9_4082585_4082736 0.25 RP11-70J12.1
10776
 0.27
chr11_75218502_75218831 0.25 RP11-939C17.4
770
 0.59
chr19_934349_934769 0.25 ARID3A
 AT rich interactive domain 3A (BRIGHT-like)
 2050
 0.15
chr13_49435917_49436145 0.25 ENSG00000265585
 .
 68317
 0.11
chr22_38029281_38029617 0.25 SH3BP1
 SH3-domain binding protein 1
 6033
 0.11
chr12_56414258_56414409 0.24 IKZF4
 IKAROS family zinc finger 4 (Eos)
 499
 0.6
chr21_36408185_36408474 0.24 RUNX1
 runt-related transcription factor 1
 13133
 0.31
chr20_30457298_30457514 0.24 DUSP15
 dual specificity phosphatase 15
 395
 0.71
chr7_151048271_151048422 0.24 NUB1
 negative regulator of ubiquitin-like proteins 1
 5915
 0.16
chr2_113404081_113404232 0.24 SLC20A1
 solute carrier family 20 (phosphate transporter), member 1
 722
 0.69
chr1_42272500_42272651 0.24 ENSG00000264896
 .
 47763
 0.18
chr12_94600310_94600885 0.24 RP11-74K11.2
20777
 0.19
chr5_133879974_133880666 0.24 JADE2
 jade family PHD finger 2
 17993
 0.15
chr7_27938817_27939020 0.24 ENSG00000265382
 .
 18812
 0.24
chr2_231977221_231977372 0.24 HTR2B
 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
 12536
 0.15
chr7_5649047_5649443 0.24 FSCN1
 fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)
 14928
 0.16
chr12_124978539_124978958 0.24 NCOR2
 nuclear receptor corepressor 2
 1050
 0.68
chr11_1885891_1886314 0.24 LSP1
 lymphocyte-specific protein 1
 293
 0.69
chr19_41329835_41330195 0.23 EGLN2
 egl-9 family hypoxia-inducible factor 2
 16867
 0.11
chr5_172200499_172201004 0.23 DUSP1
 dual specificity phosphatase 1
 2553
 0.2
chr12_53578247_53578590 0.23 CSAD
 cysteine sulfinic acid decarboxylase
 3283
 0.14
chrX_128892305_128892642 0.23 XPNPEP2
 X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound
 19475
 0.18
chrX_106175914_106176065 0.23 CLDN2
 claudin 2
 12355
 0.2
chr2_7148460_7148835 0.23 RNF144A
 ring finger protein 144A
 11576
 0.24
chr18_21966009_21966160 0.23 OSBPL1A
 oxysterol binding protein-like 1A
 11668
 0.15
chr2_28586534_28586721 0.23 FOSL2
 FOS-like antigen 2
 29042
 0.15
chr9_129887874_129888025 0.23 ANGPTL2
 angiopoietin-like 2
 2787
 0.33
chr13_32434206_32434357 0.23 EEF1DP3
 eukaryotic translation elongation factor 1 delta pseudogene 3
 92436
 0.09
chr12_106476343_106476494 0.23 NUAK1
 NUAK family, SNF1-like kinase, 1
 1393
 0.5
chr16_19138994_19139145 0.23 RP11-626G11.3
6118
 0.17
chr2_197066450_197066719 0.23 ENSG00000239161
 .
 13462
 0.18
chr20_57733456_57733718 0.22 ZNF831
 zinc finger protein 831
 32488
 0.19
chr6_76459106_76459699 0.22 MYO6
 myosin VI
 353
 0.88
chr16_27248607_27249099 0.22 NSMCE1
 non-SMC element 1 homolog (S. cerevisiae)
 4454
 0.19
chr5_115844005_115844156 0.22 SEMA6A
 sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
 28044
 0.22
chr16_57161336_57161487 0.22 CPNE2
 copine II
 8300
 0.15
chr1_19394717_19394868 0.22 UBR4
 ubiquitin protein ligase E3 component n-recognin 4
 13942
 0.19
chr3_126217149_126217300 0.22 UROC1
 urocanate hydratase 1
 19372
 0.13
chr15_67219603_67219754 0.22 SMAD3
 SMAD family member 3
 136423
 0.05
chr6_100055589_100055740 0.22 PRDM13
 PR domain containing 13
 1058
 0.51
chr11_35327376_35327706 0.22 SLC1A2
 solute carrier family 1 (glial high affinity glutamate transporter), member 2
 4466
 0.23
chr16_57167278_57167429 0.22 CPNE2
 copine II
 14242
 0.14
chr2_131132025_131132424 0.22 PTPN18
 protein tyrosine phosphatase, non-receptor type 18 (brain-derived)
 4562
 0.17
chr2_27296602_27297161 0.22 OST4
 oligosaccharyltransferase 4 homolog (S. cerevisiae)
 2240
 0.12
chr8_1901926_1902200 0.22 KBTBD11
 kelch repeat and BTB (POZ) domain containing 11
 19981
 0.23
chr1_25831625_25831776 0.22 LDLRAP1
 low density lipoprotein receptor adaptor protein 1
 38371
 0.14
chr3_107819281_107819678 0.22 CD47
 CD47 molecule
 9607
 0.3
chr9_4760903_4761054 0.21 AK3
 adenylate kinase 3
 18935
 0.17
chr16_86803007_86803158 0.21 FOXL1
 forkhead box L1
 190967
 0.03
chr14_81630336_81630487 0.21 RP11-114N19.3
6347
 0.25
chr17_42844116_42844267 0.21 ADAM11
 ADAM metallopeptidase domain 11
 7498
 0.14
chr10_33284606_33284757 0.21 ITGB1
 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
 3290
 0.32
chr3_52267957_52268256 0.21 TLR9
 TLR9
 2900
 0.13
chr11_122599812_122599963 0.21 ENSG00000239079
 .
 2868
 0.34
chr8_37822610_37823607 0.21 ADRB3
 adrenoceptor beta 3
 1375
 0.34
chr1_151117119_151117270 0.21 SEMA6C
 sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C
 1739
 0.18
chr19_4473935_4474715 0.21 HDGFRP2
 Hepatoma-derived growth factor-related protein 2
 564
 0.54
chr22_45404880_45405307 0.21 PHF21B
 PHD finger protein 21B
 219
 0.95
chr3_190414491_190414848 0.21 ENSG00000223117
 .
 54717
 0.15
chr18_2975917_2976088 0.21 LPIN2
 lipin 2
 6869
 0.16
chr20_37079512_37079663 0.21 ENSG00000199266
 .
 1574
 0.2
chr15_86128935_86129221 0.21 RP11-815J21.2
5669
 0.19
chr16_85963082_85963233 0.21 IRF8
 interferon regulatory factor 8
 15238
 0.24
chr10_105665248_105665814 0.21 OBFC1
 oligonucleotide/oligosaccharide-binding fold containing 1
 11896
 0.17
chr22_17538917_17539068 0.21 IL17RA
 interleukin 17 receptor A
 26857
 0.14
chr2_30937309_30937483 0.21 CAPN13
 calpain 13
 92915
 0.09
chr9_92076120_92076631 0.21 SEMA4D
 sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
 5507
 0.26
chr15_70049707_70049903 0.20 ENSG00000238870
 .
 26644
 0.2
chr6_166900667_166901285 0.20 ENSG00000222958
 .
 21945
 0.16
chr3_16384271_16384422 0.20 RP11-415F23.4
2287
 0.27
chr8_1320967_1321354 0.20 DLGAP2
 discs, large (Drosophila) homolog-associated protein 2
 128372
 0.06
chr10_103226335_103226486 0.20 ENSG00000239091
 .
 94701
 0.06
chr9_278055_278426 0.20 DOCK8
 dedicator of cytokinesis 8
 5170
 0.21
chr16_75661991_75662169 0.20 ADAT1
 adenosine deaminase, tRNA-specific 1
 4882
 0.15
chr13_100071950_100072184 0.20 ENSG00000266207
 .
 33656
 0.15
chr19_15400617_15401337 0.20 BRD4
 bromodomain containing 4
 9715
 0.18
chr9_139014504_139014903 0.20 C9orf69
 chromosome 9 open reading frame 69
 3972
 0.23
chr15_91230173_91230369 0.20 RP11-387D10.3
26301
 0.12
chr6_159625174_159625325 0.20 FNDC1
 fibronectin type III domain containing 1
 6770
 0.22
chr7_37305599_37305750 0.20 ELMO1
 engulfment and cell motility 1
 43381
 0.17
chr6_158087850_158088001 0.20 ZDHHC14
 zinc finger, DHHC-type containing 14
 73884
 0.11
chr7_92267627_92267778 0.20 FAM133B
 family with sequence similarity 133, member B
 47994
 0.14
chr10_90656340_90656541 0.20 STAMBPL1
 STAM binding protein-like 1
 4392
 0.2
chr12_124044061_124044270 0.20 ENSG00000266655
 .
 23209
 0.11
chrX_153606522_153606774 0.19 EMD
 emerin
 909
 0.35
chr16_85169897_85170486 0.19 FAM92B
 family with sequence similarity 92, member B
 24077
 0.18
chr5_112107941_112108092 0.19 ENSG00000212370
 .
 6044
 0.23
chrX_20280109_20280362 0.19 RPS6KA3
 ribosomal protein S6 kinase, 90kDa, polypeptide 3
 4525
 0.3
chr3_194929559_194929710 0.19 ENSG00000206600
 .
 5882
 0.18
chr11_128421567_128421718 0.19 RP11-1007G5.2
25605
 0.2
chr11_35294355_35294642 0.19 SLC1A2
 solute carrier family 1 (glial high affinity glutamate transporter), member 2
 7206
 0.18
chr1_213097977_213098128 0.19 VASH2
 vasohibin 2
 25810
 0.18
chr17_17078547_17078698 0.19 MPRIP
 myosin phosphatase Rho interacting protein
 56
 0.95
chr2_112132645_112132888 0.19 ENSG00000266139
 .
 54098
 0.18
chr19_47731951_47732818 0.19 BBC3
 BCL2 binding component 3
 2067
 0.22
chr19_42706331_42706855 0.19 ENSG00000265122
 .
 9363
 0.09
chr9_139298088_139298507 0.19 SDCCAG3
 serologically defined colon cancer antigen 3
 3340
 0.13
chr10_54413332_54413483 0.19 RP11-556E13.1
92542
 0.09
chr10_52304911_52305098 0.19 ENSG00000251950
 .
 40459
 0.14
chr10_90552652_90552880 0.19 LIPM
 lipase, family member M
 9721
 0.18
chr1_202132763_202133787 0.19 PTPN7
 protein tyrosine phosphatase, non-receptor type 7
 2559
 0.21
chr14_91814952_91815599 0.19 ENSG00000265856
 .
 15218
 0.22
chr2_100478654_100479136 0.19 AFF3
 AF4/FMR2 family, member 3
 242097
 0.02
chr8_81992943_81993251 0.19 PAG1
 phosphoprotein associated with glycosphingolipid microdomains 1
 31206
 0.23
chr11_64121545_64121911 0.19 RPS6KA4
 ribosomal protein S6 kinase, 90kDa, polypeptide 4
 4892
 0.09
chr16_1351228_1351529 0.19 UBE2I
 ubiquitin-conjugating enzyme E2I
 7503
 0.09
chr22_46691822_46692448 0.19 GTSE1
 G-2 and S-phase expressed 1
 503
 0.76
chr17_76412475_76412647 0.18 AC061992.1
 Uncharacterized protein
 9848
 0.14
chr10_30668096_30668247 0.18 ENSG00000239625
 .
 12924
 0.16
chr3_113933161_113933548 0.18 RP11-553L6.2
116
 0.96
chr17_72588858_72589016 0.18 CD300LD
 CD300 molecule-like family member d
 515
 0.68
chr11_59822676_59822875 0.18 MS4A3
 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
 1285
 0.44
chr1_227731215_227731366 0.18 ENSG00000202264
 .
 17592
 0.2
chrX_128774957_128775108 0.18 APLN
 apelin
 7710
 0.26
chr11_73721865_73722409 0.18 UCP3
 uncoupling protein 3 (mitochondrial, proton carrier)
 1657
 0.32
chr2_197944268_197944419 0.18 ANKRD44
 ankyrin repeat domain 44
 31225
 0.22
chr8_9022198_9022349 0.18 RP11-10A14.4
 Uncharacterized protein
 12960
 0.17
chr9_140162312_140162640 0.18 TOR4A
 torsin family 4, member A
 9725
 0.07
chr7_138747161_138747312 0.18 ZC3HAV1
 zinc finger CCCH-type, antiviral 1
 16777
 0.19
chr1_16751681_16751832 0.18 SPATA21
 spermatogenesis associated 21
 11929
 0.14
chr18_10060647_10060798 0.18 ENSG00000263630
 .
 55528
 0.15
chr14_75428743_75429108 0.18 PGF
 placental growth factor
 6438
 0.15
chr10_71721356_71721785 0.18 COL13A1
 collagen, type XIII, alpha 1
 31361
 0.19
chr9_4621034_4621322 0.18 PPAPDC2
 phosphatidic acid phosphatase type 2 domain containing 2
 41120
 0.13
chr1_33723200_33724119 0.18 ZNF362
 zinc finger protein 362
 1485
 0.38
chr3_63917329_63917607 0.18 ATXN7
 ataxin 7
 19193
 0.16
chr16_79313034_79313388 0.18 ENSG00000222244
 .
 14860
 0.29
chr5_53902252_53902403 0.18 SNX18
 sorting nexin 18
 88734
 0.09
chr8_22581370_22581593 0.18 ENSG00000253125
 .
 23535
 0.13
chr1_40557010_40557161 0.18 PPT1
 palmitoyl-protein thioesterase 1
 678
 0.7
chr7_37354921_37355641 0.18 ELMO1
 engulfment and cell motility 1
 27086
 0.19

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of NR1D1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0007042 lysosomal lumen acidification(GO:0007042) regulation of lysosomal lumen pH(GO:0035751)
0.0 0.2 GO:0001820 serotonin secretion(GO:0001820)
0.0 0.2 GO:0043116 negative regulation of vascular permeability(GO:0043116)
0.0 0.1 GO:0070777 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0 0.1 GO:0008588 release of cytoplasmic sequestered NF-kappaB(GO:0008588)
0.0 0.1 GO:0034392 negative regulation of smooth muscle cell apoptotic process(GO:0034392)
0.0 0.1 GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.0 0.1 GO:0033152 immunoglobulin V(D)J recombination(GO:0033152)
0.0 0.1 GO:1902745 positive regulation of lamellipodium assembly(GO:0010592) positive regulation of lamellipodium organization(GO:1902745)
0.0 0.1 GO:0005997 xylulose metabolic process(GO:0005997)
0.0 0.1 GO:0010040 response to iron(II) ion(GO:0010040)
0.0 0.1 GO:0031580 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.0 0.2 GO:0030853 negative regulation of granulocyte differentiation(GO:0030853)
0.0 0.2 GO:0016264 gap junction assembly(GO:0016264)
0.0 0.2 GO:0002710 negative regulation of T cell mediated immunity(GO:0002710)
0.0 0.2 GO:0046827 positive regulation of protein export from nucleus(GO:0046827)
0.0 0.1 GO:0002025 vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure(GO:0002025)
0.0 0.1 GO:0051938 L-glutamate import(GO:0051938)
0.0 0.0 GO:0016242 negative regulation of macroautophagy(GO:0016242)
0.0 0.0 GO:0071803 regulation of podosome assembly(GO:0071801) positive regulation of podosome assembly(GO:0071803)
0.0 0.1 GO:0009138 pyrimidine nucleoside diphosphate metabolic process(GO:0009138)
0.0 0.2 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.0 0.2 GO:0030851 granulocyte differentiation(GO:0030851)
0.0 0.1 GO:0045906 negative regulation of vasoconstriction(GO:0045906)
0.0 0.0 GO:0002313 mature B cell differentiation involved in immune response(GO:0002313)
0.0 0.1 GO:0032227 negative regulation of synaptic transmission, dopaminergic(GO:0032227)
0.0 0.1 GO:0060754 mast cell chemotaxis(GO:0002551) regulation of mast cell chemotaxis(GO:0060753) positive regulation of mast cell chemotaxis(GO:0060754) mast cell migration(GO:0097531)
0.0 0.2 GO:0000085 mitotic G2 phase(GO:0000085) G2 phase(GO:0051319)
0.0 0.0 GO:0006154 adenosine catabolic process(GO:0006154)
0.0 0.1 GO:0006924 activation-induced cell death of T cells(GO:0006924)
0.0 0.1 GO:0045163 clustering of voltage-gated potassium channels(GO:0045163)
0.0 0.1 GO:0045793 positive regulation of cell size(GO:0045793)
0.0 0.1 GO:0031115 negative regulation of microtubule polymerization(GO:0031115)
0.0 0.1 GO:0032927 positive regulation of activin receptor signaling pathway(GO:0032927)
0.0 0.1 GO:0006498 N-terminal protein lipidation(GO:0006498)
0.0 0.1 GO:0009301 snRNA transcription(GO:0009301)
0.0 0.0 GO:2000794 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501) regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000794)
0.0 0.0 GO:0072007 mesangial cell differentiation(GO:0072007) kidney interstitial fibroblast differentiation(GO:0072071) renal interstitial fibroblast development(GO:0072141) mesangial cell development(GO:0072143) pericyte cell differentiation(GO:1904238)
0.0 0.2 GO:0046716 muscle cell cellular homeostasis(GO:0046716)
0.0 0.1 GO:0044341 sodium-dependent phosphate transport(GO:0044341)
0.0 0.0 GO:0046940 nucleoside monophosphate phosphorylation(GO:0046940)
0.0 0.1 GO:0035020 regulation of Rac protein signal transduction(GO:0035020)
0.0 0.0 GO:2000188 regulation of cholesterol homeostasis(GO:2000188) positive regulation of cholesterol homeostasis(GO:2000189)
0.0 0.1 GO:0015705 iodide transport(GO:0015705)
0.0 0.1 GO:0034755 iron ion transmembrane transport(GO:0034755)
0.0 0.1 GO:0055091 phospholipid homeostasis(GO:0055091)
0.0 0.1 GO:0051569 regulation of histone H3-K4 methylation(GO:0051569)
0.0 0.0 GO:0045722 positive regulation of gluconeogenesis(GO:0045722)
0.0 0.1 GO:0007130 synaptonemal complex assembly(GO:0007130)
0.0 0.0 GO:0010511 regulation of phosphatidylinositol biosynthetic process(GO:0010511)
0.0 0.1 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.0 0.0 GO:0035405 histone-threonine phosphorylation(GO:0035405)
0.0 0.1 GO:0019987 obsolete negative regulation of anti-apoptosis(GO:0019987)
0.0 0.1 GO:0006198 cAMP catabolic process(GO:0006198)
0.0 0.1 GO:0032237 activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0 0.1 GO:0000098 sulfur amino acid catabolic process(GO:0000098)
0.0 0.2 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.0 0.0 GO:1901534 positive regulation of megakaryocyte differentiation(GO:0045654) positive regulation of hematopoietic progenitor cell differentiation(GO:1901534)
0.0 0.0 GO:0010831 positive regulation of myotube differentiation(GO:0010831)
0.0 0.0 GO:0071502 cellular response to temperature stimulus(GO:0071502)
0.0 0.0 GO:0008295 spermidine biosynthetic process(GO:0008295)
0.0 0.0 GO:0002238 response to molecule of fungal origin(GO:0002238)
0.0 0.0 GO:0051971 positive regulation of transmission of nerve impulse(GO:0051971)
0.0 0.0 GO:0043301 negative regulation of myeloid leukocyte mediated immunity(GO:0002887) negative regulation of leukocyte degranulation(GO:0043301)
0.0 0.1 GO:0008089 anterograde axonal transport(GO:0008089)
0.0 0.1 GO:0042832 response to protozoan(GO:0001562) defense response to protozoan(GO:0042832)
0.0 0.0 GO:0072010 renal filtration cell differentiation(GO:0061318) glomerular epithelium development(GO:0072010) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.0 0.0 GO:0006167 AMP biosynthetic process(GO:0006167)
0.0 0.0 GO:0060670 branching involved in labyrinthine layer morphogenesis(GO:0060670)
0.0 0.0 GO:0032898 neurotrophin production(GO:0032898)
0.0 0.2 GO:0032011 ARF protein signal transduction(GO:0032011)
0.0 0.1 GO:0016572 histone phosphorylation(GO:0016572)
0.0 0.2 GO:0034199 activation of protein kinase A activity(GO:0034199)
0.0 0.0 GO:0045835 negative regulation of meiotic nuclear division(GO:0045835)
0.0 0.1 GO:0008340 determination of adult lifespan(GO:0008340)
0.0 0.1 GO:0070935 3'-UTR-mediated mRNA stabilization(GO:0070935)
0.0 0.0 GO:0002606 positive regulation of dendritic cell antigen processing and presentation(GO:0002606)
0.0 0.0 GO:0060437 lung growth(GO:0060437)
0.0 0.0 GO:0032661 interleukin-18 production(GO:0032621) regulation of interleukin-18 production(GO:0032661)
0.0 0.0 GO:0052805 histidine catabolic process(GO:0006548) imidazole-containing compound catabolic process(GO:0052805)
0.0 0.0 GO:0002295 T-helper cell lineage commitment(GO:0002295) alpha-beta T cell lineage commitment(GO:0002363) CD4-positive, alpha-beta T cell lineage commitment(GO:0043373) memory T cell differentiation(GO:0043379) regulation of memory T cell differentiation(GO:0043380) positive regulation of memory T cell differentiation(GO:0043382) T-helper 17 type immune response(GO:0072538) T-helper 17 cell differentiation(GO:0072539) T-helper 17 cell lineage commitment(GO:0072540) regulation of T-helper 17 type immune response(GO:2000316) positive regulation of T-helper 17 type immune response(GO:2000318) regulation of T-helper 17 cell differentiation(GO:2000319) positive regulation of T-helper 17 cell differentiation(GO:2000321) regulation of T-helper 17 cell lineage commitment(GO:2000328) positive regulation of T-helper 17 cell lineage commitment(GO:2000330)
0.0 0.0 GO:0021869 forebrain ventricular zone progenitor cell division(GO:0021869)
0.0 0.1 GO:0033632 regulation of cell-cell adhesion mediated by integrin(GO:0033632)
0.0 0.1 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.0 0.1 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.0 0.0 GO:0051026 chiasma assembly(GO:0051026)
0.0 0.0 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.0 0.1 GO:0051491 positive regulation of filopodium assembly(GO:0051491)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0044462 external encapsulating structure part(GO:0044462)
0.0 0.0 GO:0071664 catenin-TCF7L2 complex(GO:0071664)
0.0 0.2 GO:0016461 unconventional myosin complex(GO:0016461)
0.0 0.2 GO:0030673 axolemma(GO:0030673)
0.0 0.1 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.0 0.1 GO:0000306 extrinsic component of vacuolar membrane(GO:0000306) extrinsic component of endosome membrane(GO:0031313)
0.0 0.1 GO:0000137 Golgi cis cisterna(GO:0000137)
0.0 0.1 GO:0036454 insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454)
0.0 0.1 GO:0070188 obsolete Stn1-Ten1 complex(GO:0070188)
0.0 0.1 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 0.1 GO:0060200 clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201)
0.0 0.1 GO:0030893 meiotic cohesin complex(GO:0030893)
0.0 0.0 GO:0048179 activin receptor complex(GO:0048179)
0.0 0.1 GO:0033553 rDNA heterochromatin(GO:0033553)
0.0 0.1 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.0 GO:0000942 condensed nuclear chromosome outer kinetochore(GO:0000942)
0.0 0.0 GO:0033270 paranode region of axon(GO:0033270)
0.0 0.1 GO:0005826 actomyosin contractile ring(GO:0005826)
0.0 0.1 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.0 0.3 GO:0005776 autophagosome(GO:0005776)
0.0 0.0 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0 0.0 GO:0000800 lateral element(GO:0000800)
0.0 0.1 GO:0001772 immunological synapse(GO:0001772)
0.0 0.2 GO:0016328 lateral plasma membrane(GO:0016328)
0.0 0.0 GO:0032009 early phagosome(GO:0032009)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0015065 uridine nucleotide receptor activity(GO:0015065) G-protein coupled pyrimidinergic nucleotide receptor activity(GO:0071553)
0.0 0.1 GO:0098599 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 0.1 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0 0.1 GO:0047756 chondroitin 4-sulfotransferase activity(GO:0047756)
0.0 0.1 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 0.1 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656) peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.0 0.1 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0 0.0 GO:0035014 phosphatidylinositol 3-kinase regulator activity(GO:0035014)
0.0 0.1 GO:0042608 T cell receptor binding(GO:0042608)
0.0 0.1 GO:0004465 lipoprotein lipase activity(GO:0004465)
0.0 0.1 GO:0004939 beta-adrenergic receptor activity(GO:0004939)
0.0 0.1 GO:0047623 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0 0.1 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.0 0.1 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.0 0.1 GO:0004476 mannose-6-phosphate isomerase activity(GO:0004476)
0.0 0.1 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.0 0.1 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.0 0.1 GO:0098847 single-stranded telomeric DNA binding(GO:0043047) sequence-specific single stranded DNA binding(GO:0098847)
0.0 0.1 GO:0070097 delta-catenin binding(GO:0070097)
0.0 0.1 GO:0004969 histamine receptor activity(GO:0004969)
0.0 0.1 GO:0005152 interleukin-1 receptor antagonist activity(GO:0005152)
0.0 0.1 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor(GO:0016670)
0.0 0.1 GO:0070053 thrombospondin receptor activity(GO:0070053)
0.0 0.1 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.0 0.1 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.1 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.0 0.3 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.0 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.0 0.1 GO:0004308 exo-alpha-sialidase activity(GO:0004308) alpha-sialidase activity(GO:0016997)
0.0 0.1 GO:0030275 LRR domain binding(GO:0030275)
0.0 0.1 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0 0.2 GO:0016493 C-C chemokine receptor activity(GO:0016493)
0.0 0.0 GO:0070643 vitamin D3 25-hydroxylase activity(GO:0030343) vitamin D 25-hydroxylase activity(GO:0070643)
0.0 0.0 GO:0004802 transketolase activity(GO:0004802)
0.0 0.1 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.0 GO:0035184 histone threonine kinase activity(GO:0035184)
0.0 0.1 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.0 GO:0004911 interleukin-2 receptor activity(GO:0004911)
0.0 0.1 GO:0030371 translation repressor activity(GO:0030371)
0.0 0.0 GO:0030899 calcium-dependent ATPase activity(GO:0030899)
0.0 0.1 GO:0031434 mitogen-activated protein kinase kinase binding(GO:0031434)
0.0 0.2 GO:0000146 microfilament motor activity(GO:0000146)
0.0 0.0 GO:0031685 adenosine receptor binding(GO:0031685)
0.0 0.1 GO:0044548 S100 protein binding(GO:0044548)
0.0 0.0 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.0 0.0 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 0.1 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.0 0.1 GO:0016494 C-X-C chemokine receptor activity(GO:0016494)
0.0 0.1 GO:0015651 quaternary ammonium group transmembrane transporter activity(GO:0015651)
0.0 0.1 GO:0004445 inositol-polyphosphate 5-phosphatase activity(GO:0004445) inositol trisphosphate phosphatase activity(GO:0046030)
0.0 0.1 GO:0016530 metallochaperone activity(GO:0016530)
0.0 0.0 GO:0001849 complement component C1q binding(GO:0001849)
0.0 0.0 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0 0.1 GO:0048365 Rac GTPase binding(GO:0048365)
0.0 0.2 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.0 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0 0.1 GO:0001637 G-protein coupled chemoattractant receptor activity(GO:0001637) chemokine receptor activity(GO:0004950)
0.0 0.1 GO:0005143 interleukin-12 receptor binding(GO:0005143)
0.0 0.1 GO:0017110 nucleoside-diphosphatase activity(GO:0017110)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.0 0.4 PID REELIN PATHWAY Reelin signaling pathway
0.0 0.2 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.1 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
0.0 0.0 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events
0.0 0.3 PID IL3 PATHWAY IL3-mediated signaling events
0.0 0.2 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.0 REACTOME GPVI MEDIATED ACTIVATION CASCADE Genes involved in GPVI-mediated activation cascade
0.0 0.3 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.0 0.3 REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.0 0.1 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.0 0.1 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 0.0 REACTOME ACYL CHAIN REMODELLING OF PC Genes involved in Acyl chain remodelling of PC
0.0 0.2 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.2 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 0.1 REACTOME PROSTANOID LIGAND RECEPTORS Genes involved in Prostanoid ligand receptors
0.0 0.3 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 0.1 REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.0 0.2 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0 0.0 REACTOME SIGNALING BY WNT Genes involved in Signaling by Wnt
0.0 0.1 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.0 0.1 REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA Genes involved in G beta:gamma signalling through PLC beta
0.0 0.2 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.1 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway