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ENCODE: H3K4me1 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for OLIG2_NEUROD1_ATOH1

Z-value: 1.07

Motif logo

Transcription factors associated with OLIG2_NEUROD1_ATOH1

Gene Symbol	Gene ID	Gene Info
OLIG2 Ensembl NCBI GeneCards UniProt	ENSG00000205927.4	OLIG2
NEUROD1 Ensembl NCBI GeneCards UniProt	ENSG00000162992.3	NEUROD1
ATOH1 Ensembl NCBI GeneCards UniProt	ENSG00000172238.3	ATOH1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
ATOH1	chr4_94755891_94756042	5924	0.270935	0.58	1.0e-01	Click!
ATOH1	chr4_94750213_94750368	248	0.946342	0.48	1.9e-01	Click!
ATOH1	chr4_94749649_94749800	318	0.923335	0.38	3.2e-01	Click!
ATOH1	chr4_94749842_94750092	75	0.981105	0.34	3.7e-01	Click!
ATOH1	chr4_94755666_94755817	5699	0.272741	0.33	3.9e-01	Click!
NEUROD1	chr2_182546095_182546262	575	0.691130	-0.51	1.6e-01	Click!
NEUROD1	chr2_182537560_182537711	7968	0.186963	-0.51	1.6e-01	Click!
NEUROD1	chr2_182546333_182546484	805	0.535301	-0.45	2.3e-01	Click!
NEUROD1	chr2_182546571_182546722	1043	0.398476	-0.43	2.5e-01	Click!
NEUROD1	chr2_182545549_182545700	21	0.973141	-0.33	3.9e-01	Click!
OLIG2	chr21_34414432_34414583	16264	0.167028	0.88	1.7e-03	Click!
OLIG2	chr21_34400775_34400926	2607	0.282370	-0.73	2.4e-02	Click!
OLIG2	chr21_34312598_34312749	85480	0.066605	-0.71	3.1e-02	Click!
OLIG2	chr21_34401737_34401918	3584	0.241023	-0.69	3.9e-02	Click!
OLIG2	chr21_34415527_34415678	17359	0.163903	0.69	4.0e-02	Click!

Activity of the OLIG2_NEUROD1_ATOH1 motif across conditions

Conditions sorted by the z-value of the OLIG2_NEUROD1_ATOH1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr1_224752371_224752739	0.81	RP11-100E13.1		51367	0.13
chr20_47299343_47299823	0.55	ENSG00000251876	.	56402	0.16
chr16_67441027_67441178	0.49	ZDHHC1	zinc finger, DHHC-type containing 1	6208	0.11
chr2_38099360_38099826	0.46	RMDN2	regulator of microtubule dynamics 2	50737	0.16
chr13_107025163_107025401	0.34	EFNB2	ephrin-B2	162180	0.04
chr2_129063259_129063630	0.34	HS6ST1	heparan sulfate 6-O-sulfotransferase 1	12707	0.24
chr1_157972060_157972325	0.34	KIRREL	kin of IRRE like (Drosophila)	8757	0.22
chr5_38463728_38464142	0.34	CTD-2263F21.1		4474	0.2
chr3_197193587_197193738	0.34	BDH1	3-hydroxybutyrate dehydrogenase, type 1	47604	0.16
chr1_68036465_68036756	0.33	ENSG00000207504	.	29800	0.2
chr3_125230252_125231290	0.32	ENSG00000201800	.	5052	0.18
chr1_17559878_17560367	0.32	PADI1	peptidyl arginine deiminase, type I	272	0.9
chr3_111581987_111582138	0.32	PHLDB2	pleckstrin homology-like domain, family B, member 2	3419	0.33
chr8_23780024_23780175	0.31	STC1	stanniocalcin 1	67779	0.11
chr22_18452853_18453098	0.31	ENSG00000207780	.	10752	0.16
chr16_15135229_15135584	0.31	NTAN1	N-terminal asparagine amidase	14490	0.12
chr13_34931777_34932168	0.31	ENSG00000199196	.	256997	0.02
chr5_88082371_88082821	0.31	MEF2C	myocyte enhancer factor 2C	37009	0.19
chrX_13395676_13395827	0.30	ATXN3L	ataxin 3-like	57233	0.14
chr6_150589389_150589540	0.30	ENSG00000201628	.	58435	0.12
chr6_3472796_3472947	0.30	SLC22A23	solute carrier family 22, member 23	15615	0.27
chr7_134483017_134483168	0.30	CALD1	caldesmon 1	18663	0.27
chr9_97567295_97567893	0.29	ENSG00000252153	.	4650	0.2
chr8_38899691_38899968	0.29	ENSG00000207199	.	23627	0.15
chr7_102515337_102515656	0.29	ENSG00000238324	.	17599	0.16
chr1_212844814_212845399	0.29	ENSG00000207491	.	20500	0.14
chr19_11379736_11379971	0.29	DOCK6	dedicator of cytokinesis 6	6725	0.11
chr18_43381728_43382214	0.29	SIGLEC15	sialic acid binding Ig-like lectin 15	23506	0.18
chr1_11219081_11219232	0.29	ENSG00000253086	.	6749	0.12
chr11_10401385_10401536	0.29	ENSG00000221574	.	19404	0.18
chr9_96902563_96902834	0.29	ENSG00000199165	.	35536	0.13
chr1_27626340_27626505	0.29	TMEM222	transmembrane protein 222	22229	0.11
chr1_235133357_235133864	0.29	ENSG00000239690	.	93677	0.08
chr15_34531267_34531418	0.28	EMC4	ER membrane protein complex subunit 4	11446	0.14
chr4_8279768_8280067	0.28	HTRA3	HtrA serine peptidase 3	8413	0.23
chr6_34579346_34579497	0.28	SPDEF	SAM pointed domain containing ETS transcription factor	55311	0.09
chr9_738796_739027	0.28	KANK1	KN motif and ankyrin repeat domains 1	6295	0.26
chr5_16889984_16890135	0.28	MYO10	myosin X	26577	0.18
chr2_163100407_163100558	0.28	FAP	fibroblast activation protein, alpha	437	0.87
chr9_111240432_111240727	0.28	ENSG00000222512	.	119370	0.06
chr12_125140025_125140381	0.27	NCOR2	nuclear receptor corepressor 2	88193	0.09
chr1_234755566_234755985	0.27	IRF2BP2	interferon regulatory factor 2 binding protein 2	10504	0.19
chr6_37423751_37423902	0.27	CMTR1	cap methyltransferase 1	19269	0.19
chr3_45595189_45595741	0.27	ENSG00000251927	.	38282	0.14
chr4_57946942_57947313	0.27	ENSG00000238541	.	25384	0.14
chr8_49341467_49342503	0.27	ENSG00000252710	.	121395	0.06
chr21_27762806_27762957	0.27	AP001596.6		426	0.86
chr16_73080724_73080969	0.27	ZFHX3	zinc finger homeobox 3	1428	0.47
chr18_67913117_67913400	0.27	RTTN	rotatin	40077	0.17
chr3_27565967_27566162	0.26	ENSG00000201033	.	10702	0.2
chr9_22104325_22104476	0.26	CDKN2B-AS1	CDKN2B antisense RNA 1	9277	0.26
chr4_8192745_8193409	0.26	SH3TC1	SH3 domain and tetratricopeptide repeats 1	8014	0.22
chr15_74723736_74724127	0.26	SEMA7A	semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)	2070	0.25
chr6_9140445_9140596	0.26	SLC35B3	solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B3	704726	0.0
chr10_62190055_62190299	0.26	ANK3	ankyrin 3, node of Ranvier (ankyrin G)	40689	0.22
chr10_101152343_101152513	0.26	GOT1	glutamic-oxaloacetic transaminase 1, soluble	37774	0.17
chr2_74803113_74803707	0.26	LOXL3	lysyl oxidase-like 3	20593	0.09
chr12_89938377_89938528	0.26	RP11-981P6.1		16454	0.12
chr15_74823309_74823460	0.26	ARID3B	AT rich interactive domain 3B (BRIGHT-like)	10134	0.16
chr1_3456323_3456645	0.25	MEGF6	multiple EGF-like-domains 6	8472	0.18
chr17_61356441_61356592	0.25	RP11-269G24.2		34366	0.16
chr12_65925506_65925921	0.25	MSRB3	methionine sulfoxide reductase B3	205058	0.02
chr4_15452943_15453218	0.25	CC2D2A	coiled-coil and C2 domain containing 2A	18409	0.16
chr15_99439423_99439701	0.25	RP11-654A16.1		2798	0.29
chr4_77484588_77484771	0.25	ENSG00000263445	.	10042	0.16
chr3_30537171_30537700	0.25	TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	110559	0.07
chr3_73596607_73596758	0.25	PDZRN3	PDZ domain containing ring finger 3	14087	0.24
chr16_72912139_72912450	0.25	ENSG00000251868	.	56403	0.11
chr8_16570287_16570438	0.25	MSR1	macrophage scavenger receptor 1	145491	0.05
chr22_33141298_33141449	0.25	LL22NC01-116C6.1		37790	0.18
chr15_99271535_99272053	0.25	IGF1R	insulin-like growth factor 1 receptor	20734	0.22
chr1_59050905_59051237	0.25	TACSTD2	tumor-associated calcium signal transducer 2	7905	0.21
chr19_47234584_47234910	0.25	CTB-174O21.2		2887	0.12
chr20_60931015_60931270	0.25	RP11-157P1.5		3073	0.16
chr10_116394275_116394426	0.25	ENSG00000238577	.	21919	0.21
chr16_59732879_59733030	0.25	RP11-105C20.2	Uncharacterized protein	55764	0.17
chr9_121765469_121765620	0.24	BRINP1	bone morphogenetic protein/retinoic acid inducible neural-specific 1	366159	0.01
chr7_127526528_127526679	0.24	SND1	staphylococcal nuclease and tudor domain containing 1	1362	0.57
chr12_52541532_52541683	0.24	ENSG00000265804	.	33898	0.09
chr10_36778471_36778622	0.24	NAMPTL	nicotinamide phosphoribosyltransferase-like	33777	0.21
chr6_140384059_140384419	0.24	ENSG00000252107	.	95592	0.09
chr1_110476345_110476632	0.24	CSF1	colony stimulating factor 1 (macrophage)	22880	0.15
chr5_95592588_95592739	0.24	ENSG00000206997	.	46732	0.18
chr20_43966974_43967184	0.24	SDC4	syndecan 4	9985	0.12
chr14_88937886_88938037	0.24	PTPN21	protein tyrosine phosphatase, non-receptor type 21	2001	0.3
chr21_47480957_47481280	0.24	AP001471.1		36326	0.12
chr6_53445863_53446014	0.24	GCLC	glutamate-cysteine ligase, catalytic subunit	35830	0.15
chr17_62051771_62052003	0.24	SCN4A	sodium channel, voltage-gated, type IV, alpha subunit	1609	0.28
chr5_71622210_71622361	0.24	PTCD2	pentatricopeptide repeat domain 2	6060	0.19
chr3_43770825_43770976	0.24	ABHD5	abhydrolase domain containing 5	17701	0.24
chr7_129912749_129913103	0.24	CPA2	carboxypeptidase A2 (pancreatic)	6259	0.15
chr10_127836908_127837102	0.24	ENSG00000222740	.	2854	0.38
chr2_36715343_36715494	0.24	CRIM1	cysteine rich transmembrane BMP regulator 1 (chordin-like)	25415	0.18
chr2_43746582_43747032	0.24	THADA	thyroid adenoma associated	50847	0.15
chr2_75730636_75730787	0.24	ENSG00000238410	.	14009	0.14
chr5_156944293_156944560	0.24	ADAM19	ADAM metallopeptidase domain 19	14596	0.16
chr1_197751092_197751472	0.24	DENND1B	DENN/MADD domain containing 1B	6519	0.24
chr3_149096434_149096694	0.24	TM4SF1-AS1	TM4SF1 antisense RNA 1	558	0.59
chr2_112461565_112461786	0.24	ENSG00000266063	.	67036	0.13
chr5_71448848_71449179	0.23	ENSG00000264099	.	16281	0.23
chr15_33149195_33149346	0.23	FMN1	formin 1	31185	0.18
chr4_75072940_75073180	0.23	AC093677.1	Uncharacterized protein	48975	0.12
chr1_2145701_2146237	0.23	AL590822.1	Uncharacterized protein	349	0.81
chr5_121462821_121463158	0.23	ZNF474	zinc finger protein 474	2219	0.3
chr4_77906953_77907316	0.23	SEPT11	septin 11	957	0.65
chr17_56309797_56310163	0.23	LPO	lactoperoxidase	5807	0.14
chrX_39756614_39756930	0.23	ENSG00000263972	.	59957	0.15
chr14_64081611_64082063	0.23	ENSG00000202490	.	2924	0.18
chr8_98000923_98001119	0.23	CPQ	carboxypeptidase Q	40676	0.21
chr1_180268578_180268834	0.23	RP5-1180C10.2		23347	0.21
chr12_2397196_2397863	0.23	CACNA1C-IT3	CACNA1C intronic transcript 3 (non-protein coding)	18587	0.24
chr4_72117195_72117346	0.23	SLC4A4	solute carrier family 4 (sodium bicarbonate cotransporter), member 4	64226	0.15
chr11_65682626_65682804	0.23	C11orf68	chromosome 11 open reading frame 68	3116	0.11
chr8_103740973_103741124	0.23	ENSG00000266799	.	4899	0.26
chr17_59392029_59392180	0.23	RP11-332H18.3		68042	0.09
chr7_50602464_50602700	0.23	AC018705.5		3125	0.27
chr18_55671000_55671151	0.23	ENSG00000265200	.	13041	0.24
chr2_65598363_65598650	0.23	SPRED2	sprouty-related, EVH1 domain containing 2	4722	0.25
chr2_162275033_162275920	0.23	TBR1	T-box, brain, 1	1070	0.48
chr7_75401991_75402142	0.23	CCL26	chemokine (C-C motif) ligand 26	491	0.8
chr5_77793836_77794265	0.23	LHFPL2	lipoma HMGIC fusion partner-like 2	50924	0.17
chr6_125325392_125325543	0.23	RNF217	ring finger protein 217	20953	0.23
chr1_94282304_94282939	0.23	ENSG00000211575	.	29767	0.15
chr6_127786446_127786597	0.23	KIAA0408	KIAA0408	5985	0.27
chr1_230223105_230223256	0.23	GALNT2	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 (GalNAc-T2)	20162	0.23
chr16_54002972_54003123	0.23	RP11-357N13.3		12777	0.19
chr19_12917574_12918297	0.23	RNASEH2A	ribonuclease H2, subunit A	541	0.5
chr11_122582836_122583051	0.23	ENSG00000239079	.	14076	0.23
chr20_9389776_9389927	0.23	PLCB4	phospholipase C, beta 4	101404	0.07
chr10_62606007_62606158	0.23	CDK1	cyclin-dependent kinase 1	66171	0.12
chr19_13841374_13841557	0.23	CCDC130	coiled-coil domain containing 130	1109	0.39
chr2_47452652_47452803	0.23	CALM2	calmodulin 2 (phosphorylase kinase, delta)	48987	0.13
chr5_39759341_39759548	0.23	DAB2	Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)	297042	0.01
chr9_124161774_124161925	0.23	RP11-162D16.2		24330	0.15
chr3_152787726_152787975	0.23	RP11-529G21.2		91714	0.08
chr1_206686695_206686846	0.23	RASSF5	Ras association (RalGDS/AF-6) domain family member 5	5891	0.16
chr18_55981901_55982052	0.22	NEDD4L	neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase	8576	0.23
chr1_10588124_10588275	0.22	PEX14	peroxisomal biogenesis factor 14	53160	0.09
chr8_74282935_74283532	0.22	RP11-434I12.2		14537	0.25
chr11_125318368_125318519	0.22	FEZ1	fasciculation and elongation protein zeta 1 (zygin I)	33086	0.15
chr2_218559324_218559720	0.22	DIRC3	disrupted in renal carcinoma 3	61756	0.14
chr1_97603736_97604015	0.22	DPYD-AS1	DPYD antisense RNA 1	42396	0.21
chr20_10905923_10906156	0.22	RP11-103J8.1		23107	0.27
chr11_33743104_33743255	0.22	CD59	CD59 molecule, complement regulatory protein	823	0.56
chr12_27701944_27702208	0.22	PPFIBP1	PTPRF interacting protein, binding protein 1 (liprin beta 1)	11020	0.23
chr1_162666067_162666218	0.22	DDR2	discoidin domain receptor tyrosine kinase 2	63882	0.1
chr3_106329240_106329391	0.22	ENSG00000200361	.	78210	0.11
chr15_40622287_40622525	0.22	ENSG00000252714	.	1443	0.2
chr2_158695609_158696251	0.22	ACVR1	activin A receptor, type I	1091	0.53
chr7_55260939_55261090	0.22	EGFR-AS1	EGFR antisense RNA 1	4387	0.33
chr3_124904883_124905158	0.22	SLC12A8	solute carrier family 12, member 8	4274	0.25
chr12_76660924_76661075	0.22	ENSG00000223273	.	48532	0.16
chr4_79705695_79705981	0.22	BMP2K	BMP2 inducible kinase	8306	0.19
chr3_134076361_134076562	0.22	AMOTL2	angiomotin like 2	14293	0.22
chr5_131631159_131631712	0.22	P4HA2	prolyl 4-hydroxylase, alpha polypeptide II	471	0.69
chr9_77678975_77679126	0.22	NMRK1	nicotinamide riboside kinase 1	24056	0.14
chr13_76259014_76259165	0.22	LMO7	LIM domain 7	48630	0.13
chr10_21625403_21625600	0.22	ENSG00000207264	.	14611	0.25
chr9_124581839_124582120	0.22	RP11-244O19.1		248	0.95
chr17_42619678_42619899	0.22	FZD2	frizzled family receptor 2	15137	0.17
chr13_74784840_74784991	0.22	KLF12	Kruppel-like factor 12	76521	0.11
chr19_13147816_13148089	0.22	NFIX	nuclear factor I/X (CCAAT-binding transcription factor)	12141	0.1
chr15_74244046_74244221	0.22	LOXL1-AS1	LOXL1 antisense RNA 1	23544	0.12
chr2_174013244_174013468	0.22	MLTK	Mitogen-activated protein kinase kinase kinase MLT	58009	0.13
chr16_55533264_55533509	0.22	LPCAT2	lysophosphatidylcholine acyltransferase 2	9524	0.21
chr1_185452867_185453160	0.22	ENSG00000252407	.	49637	0.16
chr14_89653293_89653444	0.22	FOXN3	forkhead box N3	6280	0.31
chr5_395973_396219	0.22	AHRR	aryl-hydrocarbon receptor repressor	24939	0.14
chr9_78990381_78990532	0.22	RFK	riboflavin kinase	18592	0.24
chr1_171189915_171190066	0.22	RP1-127D3.4		3433	0.19
chr16_88340108_88340439	0.21	ZNF469	zinc finger protein 469	153606	0.04
chr3_127469623_127470054	0.21	MGLL	monoglyceride lipase	14638	0.23
chr14_54636067_54636218	0.21	BMP4	bone morphogenetic protein 4	210663	0.02
chr6_43083911_43084141	0.21	PTK7	protein tyrosine kinase 7	14303	0.11
chr17_47694081_47694342	0.21	SPOP	speckle-type POZ protein	29773	0.11
chr1_203539117_203539268	0.21	ATP2B4	ATPase, Ca++ transporting, plasma membrane 4	56497	0.12
chr16_88839995_88840537	0.21	PIEZO1	piezo-type mechanosensitive ion channel component 1	11353	0.09
chr1_186071380_186071531	0.21	HMCN1	hemicentin 1	69064	0.12
chr6_119469482_119469711	0.21	FAM184A	family with sequence similarity 184, member A	756	0.75
chr3_120397975_120398149	0.21	HGD	homogentisate 1,2-dioxygenase	2898	0.32
chr15_43809364_43809657	0.21	MAP1A	microtubule-associated protein 1A	296	0.87
chr7_23387609_23387938	0.21	ENSG00000212264	.	48292	0.12
chr15_22904161_22904312	0.21	CYFIP1	cytoplasmic FMR1 interacting protein 1	11520	0.2
chr5_58376080_58376374	0.21	RP11-266N13.2		40639	0.18
chr3_45102518_45102669	0.21	ENSG00000252410	.	26513	0.16
chr9_97675641_97675792	0.21	RP11-49O14.2		13005	0.18
chr5_163631145_163631296	0.21	CTC-340A15.2		92482	0.1
chr2_110863867_110864081	0.21	MALL	mal, T-cell differentiation protein-like	9625	0.15
chr10_104387858_104388403	0.21	TRIM8	tripartite motif containing 8	16123	0.16
chr11_102706754_102706905	0.21	MMP3	matrix metallopeptidase 3 (stromelysin 1, progelatinase)	2612	0.26
chr5_144740955_144741106	0.21	ENSG00000221467	.	163692	0.04
chr3_185434712_185435102	0.21	C3orf65	chromosome 3 open reading frame 65	3827	0.28
chr2_9375414_9375688	0.21	ASAP2	ArfGAP with SH3 domain, ankyrin repeat and PH domain 2	28657	0.24
chr10_80384244_80384395	0.21	ENSG00000223243	.	126040	0.06
chr6_166778430_166778581	0.21	MPC1	mitochondrial pyruvate carrier 1	17981	0.15
chr21_46829481_46829632	0.21	COL18A1-AS2	COL18A1 antisense RNA 2	424	0.8
chr2_159901322_159901473	0.21	ENSG00000202029	.	17743	0.24
chr4_129149422_129149689	0.21	PGRMC2	progesterone receptor membrane component 2	44661	0.2
chr1_208358171_208358322	0.21	PLXNA2	plexin A2	59419	0.17
chr1_25039474_25039625	0.21	CLIC4	chloride intracellular channel 4	32299	0.15

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of OLIG2_NEUROD1_ATOH1

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View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:1903053	regulation of extracellular matrix disassembly(GO:0010715) negative regulation of extracellular matrix disassembly(GO:0010716) regulation of extracellular matrix organization(GO:1903053) negative regulation of extracellular matrix organization(GO:1903054)
0.1	0.4	GO:0018101	protein citrullination(GO:0018101)
0.1	0.3	GO:0071318	cellular response to ATP(GO:0071318)
0.1	0.2	GO:0060831	smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:0060831)
0.1	0.2	GO:0060083	smooth muscle contraction involved in micturition(GO:0060083)
0.1	0.2	GO:0006003	fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.1	0.1	GO:0007221	positive regulation of transcription of Notch receptor target(GO:0007221)
0.1	0.2	GO:0035583	sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.1	0.2	GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) 4-hydroxyproline metabolic process(GO:0019471) peptidyl-proline hydroxylation(GO:0019511)
0.1	0.2	GO:0010766	negative regulation of sodium ion transport(GO:0010766)
0.1	0.1	GO:0060028	convergent extension involved in axis elongation(GO:0060028)
0.0	0.1	GO:0030011	maintenance of cell polarity(GO:0030011)
0.0	0.2	GO:0007028	cytoplasm organization(GO:0007028)
0.0	0.2	GO:0048096	chromatin-mediated maintenance of transcription(GO:0048096)
0.0	0.3	GO:0032909	transforming growth factor beta2 production(GO:0032906) regulation of transforming growth factor beta2 production(GO:0032909)
0.0	0.1	GO:0002072	optic cup morphogenesis involved in camera-type eye development(GO:0002072)
0.0	0.2	GO:0060539	diaphragm development(GO:0060539)
0.0	0.2	GO:0021535	cell migration in hindbrain(GO:0021535)
0.0	0.2	GO:0045618	positive regulation of keratinocyte differentiation(GO:0045618)
0.0	0.1	GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.0	0.1	GO:0018243	protein O-linked glycosylation via serine(GO:0018242) protein O-linked glycosylation via threonine(GO:0018243)
0.0	0.1	GO:0032467	positive regulation of cytokinesis(GO:0032467)
0.0	0.1	GO:0045198	establishment of epithelial cell apical/basal polarity(GO:0045198)
0.0	0.1	GO:0033173	calcineurin-NFAT signaling cascade(GO:0033173)
0.0	0.2	GO:0060666	dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.0	0.2	GO:0045662	negative regulation of myoblast differentiation(GO:0045662)
0.0	0.2	GO:0006307	DNA dealkylation involved in DNA repair(GO:0006307)
0.0	0.1	GO:0031946	regulation of glucocorticoid biosynthetic process(GO:0031946)
0.0	0.1	GO:0002085	inhibition of neuroepithelial cell differentiation(GO:0002085)
0.0	0.1	GO:0009169	purine nucleoside monophosphate catabolic process(GO:0009128) ribonucleoside monophosphate catabolic process(GO:0009158) purine ribonucleoside monophosphate catabolic process(GO:0009169)
0.0	0.1	GO:0034201	response to oleic acid(GO:0034201)
0.0	0.1	GO:0002043	blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.0	0.1	GO:0022617	extracellular matrix disassembly(GO:0022617)
0.0	0.1	GO:0019852	L-ascorbic acid metabolic process(GO:0019852)
0.0	0.1	GO:0008218	bioluminescence(GO:0008218)
0.0	0.1	GO:0014819	regulation of skeletal muscle contraction(GO:0014819)
0.0	0.1	GO:0070427	nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427)
0.0	0.1	GO:0032497	detection of lipopolysaccharide(GO:0032497)
0.0	0.1	GO:0031340	positive regulation of vesicle fusion(GO:0031340)
0.0	0.1	GO:0014012	peripheral nervous system axon regeneration(GO:0014012)
0.0	0.2	GO:0090136	epithelial cell-cell adhesion(GO:0090136)
0.0	0.1	GO:0032277	negative regulation of gonadotropin secretion(GO:0032277)
0.0	0.1	GO:0010662	striated muscle cell apoptotic process(GO:0010658) cardiac muscle cell apoptotic process(GO:0010659) regulation of striated muscle cell apoptotic process(GO:0010662) negative regulation of striated muscle cell apoptotic process(GO:0010664) regulation of cardiac muscle cell apoptotic process(GO:0010665) negative regulation of cardiac muscle cell apoptotic process(GO:0010667)
0.0	0.1	GO:0007132	meiotic metaphase I(GO:0007132)
0.0	0.1	GO:0032926	negative regulation of activin receptor signaling pathway(GO:0032926)
0.0	0.3	GO:0019369	arachidonic acid metabolic process(GO:0019369)
0.0	0.1	GO:0072311	renal filtration cell differentiation(GO:0061318) glomerular epithelium development(GO:0072010) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.0	0.1	GO:0090049	regulation of cell migration involved in sprouting angiogenesis(GO:0090049) regulation of sprouting angiogenesis(GO:1903670)
0.0	0.1	GO:0043589	skin morphogenesis(GO:0043589)
0.0	0.1	GO:0051045	negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
0.0	0.2	GO:0015840	urea transport(GO:0015840)
0.0	0.1	GO:0001996	positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996)
0.0	0.1	GO:0060159	regulation of dopamine receptor signaling pathway(GO:0060159)
0.0	0.1	GO:0014848	urinary tract smooth muscle contraction(GO:0014848)
0.0	0.1	GO:2000050	regulation of non-canonical Wnt signaling pathway(GO:2000050)
0.0	0.1	GO:0030490	maturation of SSU-rRNA(GO:0030490)
0.0	0.1	GO:0045077	negative regulation of interferon-gamma biosynthetic process(GO:0045077)
0.0	0.1	GO:0060014	granulosa cell differentiation(GO:0060014)
0.0	0.1	GO:0060907	positive regulation of macrophage cytokine production(GO:0060907)
0.0	0.1	GO:0060528	secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.0	0.0	GO:0061081	positive regulation of myeloid leukocyte cytokine production involved in immune response(GO:0061081)
0.0	0.0	GO:0045112	integrin biosynthetic process(GO:0045112)
0.0	0.0	GO:0001778	plasma membrane repair(GO:0001778)
0.0	0.2	GO:0090399	replicative senescence(GO:0090399)
0.0	0.0	GO:0055089	fatty acid homeostasis(GO:0055089)
0.0	0.1	GO:0032455	nerve growth factor processing(GO:0032455)
0.0	0.1	GO:1900078	positive regulation of insulin receptor signaling pathway(GO:0046628) positive regulation of cellular response to insulin stimulus(GO:1900078)
0.0	0.1	GO:0048170	positive regulation of long-term neuronal synaptic plasticity(GO:0048170)
0.0	0.1	GO:0048149	behavioral response to ethanol(GO:0048149)
0.0	0.1	GO:0007619	courtship behavior(GO:0007619)
0.0	0.1	GO:0009756	carbohydrate mediated signaling(GO:0009756)
0.0	0.1	GO:0070092	regulation of glucagon secretion(GO:0070092)
0.0	0.0	GO:0019934	cGMP-mediated signaling(GO:0019934)
0.0	0.1	GO:0021670	lateral ventricle development(GO:0021670)
0.0	0.1	GO:0032331	negative regulation of chondrocyte differentiation(GO:0032331)
0.0	0.1	GO:0071277	cellular response to calcium ion(GO:0071277)
0.0	0.1	GO:0051124	synaptic growth at neuromuscular junction(GO:0051124)
0.0	0.1	GO:0022605	oogenesis stage(GO:0022605)
0.0	0.2	GO:0014821	phasic smooth muscle contraction(GO:0014821)
0.0	0.1	GO:0048755	branching morphogenesis of a nerve(GO:0048755)
0.0	0.0	GO:0060596	mammary placode formation(GO:0060596)
0.0	0.1	GO:0072383	plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.0	0.1	GO:0061302	smooth muscle cell-matrix adhesion(GO:0061302)
0.0	0.1	GO:0061072	iris morphogenesis(GO:0061072)
0.0	0.2	GO:0007185	transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0	0.1	GO:0006337	nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.0	0.1	GO:0030321	transepithelial chloride transport(GO:0030321)
0.0	0.0	GO:0002025	vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure(GO:0002025)
0.0	0.1	GO:0070254	mucus secretion(GO:0070254)
0.0	0.1	GO:0006646	phosphatidylethanolamine biosynthetic process(GO:0006646) phosphatidylethanolamine metabolic process(GO:0046337)
0.0	0.1	GO:0006654	phosphatidic acid biosynthetic process(GO:0006654)
0.0	0.1	GO:0048016	inositol phosphate-mediated signaling(GO:0048016)
0.0	0.0	GO:0090162	establishment of epithelial cell polarity(GO:0090162)
0.0	0.1	GO:0051176	positive regulation of sulfur metabolic process(GO:0051176)
0.0	0.1	GO:0090073	positive regulation of protein homodimerization activity(GO:0090073)
0.0	0.0	GO:0006166	purine ribonucleoside salvage(GO:0006166)
0.0	0.1	GO:0018345	protein palmitoylation(GO:0018345)
0.0	0.0	GO:0033630	positive regulation of cell adhesion mediated by integrin(GO:0033630)
0.0	0.0	GO:0060433	bronchus development(GO:0060433)
0.0	0.0	GO:0042726	flavin-containing compound metabolic process(GO:0042726)
0.0	0.3	GO:0048286	lung alveolus development(GO:0048286)
0.0	0.1	GO:0070189	kynurenine metabolic process(GO:0070189)
0.0	0.1	GO:0051497	negative regulation of stress fiber assembly(GO:0051497)
0.0	0.0	GO:0002238	response to molecule of fungal origin(GO:0002238)
0.0	0.1	GO:0006572	tyrosine catabolic process(GO:0006572)
0.0	0.1	GO:0045079	negative regulation of chemokine biosynthetic process(GO:0045079)
0.0	0.0	GO:0045617	negative regulation of keratinocyte differentiation(GO:0045617)
0.0	0.1	GO:0000103	sulfate assimilation(GO:0000103)
0.0	0.0	GO:0007598	blood coagulation, extrinsic pathway(GO:0007598)
0.0	0.0	GO:0060449	bud elongation involved in lung branching(GO:0060449)
0.0	0.1	GO:0009296	obsolete flagellum assembly(GO:0009296)
0.0	0.0	GO:0003308	negative regulation of Wnt signaling pathway involved in heart development(GO:0003308)
0.0	0.1	GO:0006663	platelet activating factor biosynthetic process(GO:0006663)
0.0	0.1	GO:0033137	negative regulation of peptidyl-serine phosphorylation(GO:0033137)
0.0	0.1	GO:0008215	spermine metabolic process(GO:0008215)
0.0	0.1	GO:0032836	glomerular basement membrane development(GO:0032836)
0.0	0.2	GO:0035329	hippo signaling(GO:0035329)
0.0	0.1	GO:0090084	negative regulation of inclusion body assembly(GO:0090084)
0.0	0.1	GO:0010701	positive regulation of norepinephrine secretion(GO:0010701)
0.0	0.1	GO:0006975	DNA damage induced protein phosphorylation(GO:0006975)
0.0	0.1	GO:0002689	negative regulation of leukocyte chemotaxis(GO:0002689)
0.0	0.1	GO:0030091	protein repair(GO:0030091)
0.0	0.1	GO:0006562	proline catabolic process(GO:0006562)
0.0	0.1	GO:0072367	regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367)
0.0	0.1	GO:0046951	ketone body biosynthetic process(GO:0046951)
0.0	0.1	GO:0009249	protein lipoylation(GO:0009249)
0.0	0.0	GO:0051005	negative regulation of lipoprotein lipase activity(GO:0051005)
0.0	0.1	GO:0048261	negative regulation of receptor-mediated endocytosis(GO:0048261)
0.0	0.1	GO:0060039	pericardium development(GO:0060039)
0.0	0.0	GO:0030812	negative regulation of nucleotide catabolic process(GO:0030812)
0.0	0.0	GO:0048312	intracellular distribution of mitochondria(GO:0048312)
0.0	0.1	GO:0009629	response to gravity(GO:0009629)
0.0	0.1	GO:0071320	cellular response to cAMP(GO:0071320)
0.0	0.1	GO:0048172	regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0	0.0	GO:0090009	primitive streak formation(GO:0090009)
0.0	0.0	GO:0045683	negative regulation of epidermis development(GO:0045683)
0.0	0.1	GO:0090231	regulation of spindle checkpoint(GO:0090231)
0.0	0.2	GO:0015701	bicarbonate transport(GO:0015701)
0.0	0.0	GO:0046475	glycerophospholipid catabolic process(GO:0046475)
0.0	0.1	GO:0040015	negative regulation of multicellular organism growth(GO:0040015)
0.0	0.0	GO:0035414	negative regulation of catenin import into nucleus(GO:0035414)
0.0	0.0	GO:0045906	negative regulation of vasoconstriction(GO:0045906)
0.0	0.0	GO:0072677	eosinophil chemotaxis(GO:0048245) eosinophil migration(GO:0072677)
0.0	0.1	GO:0007020	microtubule nucleation(GO:0007020)
0.0	0.1	GO:0008228	opsonization(GO:0008228)
0.0	0.1	GO:0035413	positive regulation of catenin import into nucleus(GO:0035413)
0.0	0.0	GO:0070050	neuron cellular homeostasis(GO:0070050)
0.0	0.0	GO:0003148	outflow tract septum morphogenesis(GO:0003148)
0.0	0.0	GO:0043931	ossification involved in bone maturation(GO:0043931)
0.0	0.0	GO:0003321	positive regulation of blood pressure by epinephrine-norepinephrine(GO:0003321)
0.0	0.1	GO:0002634	regulation of germinal center formation(GO:0002634)
0.0	0.1	GO:0043569	negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.0	0.3	GO:0030574	collagen catabolic process(GO:0030574)
0.0	0.0	GO:0002686	negative regulation of leukocyte migration(GO:0002686)
0.0	0.1	GO:0006072	glycerol-3-phosphate metabolic process(GO:0006072)
0.0	0.1	GO:0007016	cytoskeletal anchoring at plasma membrane(GO:0007016)
0.0	0.0	GO:0002679	respiratory burst involved in defense response(GO:0002679)
0.0	0.1	GO:0032055	negative regulation of translation in response to stress(GO:0032055)
0.0	0.0	GO:0016576	histone dephosphorylation(GO:0016576)
0.0	0.0	GO:0006552	leucine catabolic process(GO:0006552)
0.0	0.0	GO:0072048	pattern specification involved in kidney development(GO:0061004) renal system pattern specification(GO:0072048) pattern specification involved in metanephros development(GO:0072268)
0.0	0.0	GO:0070100	Roundabout signaling pathway(GO:0035385) regulation of chemokine-mediated signaling pathway(GO:0070099) negative regulation of chemokine-mediated signaling pathway(GO:0070100)
0.0	0.1	GO:0002040	sprouting angiogenesis(GO:0002040)
0.0	0.0	GO:0070933	histone H3 deacetylation(GO:0070932) histone H4 deacetylation(GO:0070933)
0.0	0.0	GO:0032506	cytokinetic process(GO:0032506)
0.0	0.1	GO:0051319	mitotic G2 phase(GO:0000085) G2 phase(GO:0051319)
0.0	0.0	GO:0036072	intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.0	0.0	GO:0071731	response to nitric oxide(GO:0071731)
0.0	0.1	GO:0097061	dendritic spine morphogenesis(GO:0060997) regulation of dendritic spine morphogenesis(GO:0061001) dendritic spine organization(GO:0097061)
0.0	0.0	GO:0006452	translational frameshifting(GO:0006452) positive regulation of translational elongation(GO:0045901) positive regulation of translational termination(GO:0045905)
0.0	0.0	GO:0035461	vitamin transmembrane transport(GO:0035461)
0.0	0.0	GO:0045657	positive regulation of monocyte differentiation(GO:0045657)
0.0	0.0	GO:0032020	ISG15-protein conjugation(GO:0032020)
0.0	0.0	GO:0015793	glycerol transport(GO:0015793)
0.0	0.0	GO:0001955	blood vessel maturation(GO:0001955)
0.0	0.0	GO:2000300	regulation of synaptic vesicle transport(GO:1902803) regulation of synaptic vesicle exocytosis(GO:2000300)
0.0	0.1	GO:0007528	neuromuscular junction development(GO:0007528)
0.0	0.1	GO:0017187	peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214)
0.0	0.0	GO:0000470	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463) maturation of LSU-rRNA(GO:0000470)
0.0	0.0	GO:0051790	short-chain fatty acid biosynthetic process(GO:0051790)
0.0	0.1	GO:0009650	UV protection(GO:0009650)
0.0	0.0	GO:1903301	regulation of glucokinase activity(GO:0033131) positive regulation of glucokinase activity(GO:0033133) regulation of hexokinase activity(GO:1903299) positive regulation of hexokinase activity(GO:1903301)
0.0	0.0	GO:0006551	leucine metabolic process(GO:0006551)
0.0	0.0	GO:0046607	positive regulation of centrosome cycle(GO:0046607)
0.0	0.1	GO:0031268	pseudopodium organization(GO:0031268)
0.0	0.0	GO:0043268	positive regulation of potassium ion transport(GO:0043268)
0.0	0.0	GO:0060236	regulation of mitotic spindle organization(GO:0060236)
0.0	0.2	GO:0045104	intermediate filament cytoskeleton organization(GO:0045104)
0.0	0.0	GO:0019614	phenol-containing compound catabolic process(GO:0019336) catechol-containing compound catabolic process(GO:0019614) catecholamine catabolic process(GO:0042424)
0.0	0.0	GO:0051451	myoblast migration(GO:0051451)
0.0	0.0	GO:0090195	chemokine secretion(GO:0090195) regulation of chemokine secretion(GO:0090196) positive regulation of chemokine secretion(GO:0090197)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0071438	invadopodium membrane(GO:0071438)
0.0	0.1	GO:0043260	laminin-11 complex(GO:0043260)
0.0	0.0	GO:0071664	catenin-TCF7L2 complex(GO:0071664)
0.0	0.2	GO:0031362	anchored component of external side of plasma membrane(GO:0031362)
0.0	0.1	GO:0070852	cell body fiber(GO:0070852)
0.0	0.1	GO:0032299	ribonuclease H2 complex(GO:0032299)
0.0	0.2	GO:0030056	hemidesmosome(GO:0030056)
0.0	0.2	GO:0031512	motile primary cilium(GO:0031512)
0.0	0.1	GO:0016327	apicolateral plasma membrane(GO:0016327)
0.0	0.2	GO:0005915	zonula adherens(GO:0005915)
0.0	0.1	GO:0009331	glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.0	0.2	GO:0031332	RISC complex(GO:0016442) RNAi effector complex(GO:0031332)
0.0	0.2	GO:0001527	microfibril(GO:0001527)
0.0	0.2	GO:0098645	network-forming collagen trimer(GO:0098642) collagen network(GO:0098645)
0.0	0.1	GO:0048179	activin receptor complex(GO:0048179)
0.0	0.1	GO:0005588	collagen type V trimer(GO:0005588)
0.0	0.1	GO:0031312	extrinsic component of organelle membrane(GO:0031312)
0.0	0.1	GO:0030934	anchoring collagen complex(GO:0030934)
0.0	0.1	GO:0005863	striated muscle myosin thick filament(GO:0005863)
0.0	0.0	GO:0043083	synaptic cleft(GO:0043083)
0.0	0.2	GO:0002102	podosome(GO:0002102)
0.0	0.1	GO:0070044	synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
0.0	0.0	GO:0098651	basement membrane collagen trimer(GO:0098651)
0.0	0.1	GO:0005614	interstitial matrix(GO:0005614)
0.0	0.1	GO:0031430	M band(GO:0031430)
0.0	0.1	GO:0030122	AP-2 adaptor complex(GO:0030122) clathrin coat of endocytic vesicle(GO:0030128)
0.0	0.1	GO:0030061	mitochondrial crista(GO:0030061)
0.0	0.0	GO:0005589	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0	0.1	GO:0005828	kinetochore microtubule(GO:0005828)
0.0	0.0	GO:0032809	neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0	0.0	GO:0031904	endosome lumen(GO:0031904)
0.0	0.0	GO:0032591	dendritic spine membrane(GO:0032591)
0.0	0.1	GO:0016585	obsolete chromatin remodeling complex(GO:0016585)
0.0	0.1	GO:0035253	ciliary rootlet(GO:0035253)
0.0	0.0	GO:0042272	nuclear RNA export factor complex(GO:0042272)
0.0	0.1	GO:0008328	ionotropic glutamate receptor complex(GO:0008328) neurotransmitter receptor complex(GO:0098878)
0.0	0.1	GO:0043034	costamere(GO:0043034)
0.0	0.1	GO:0005862	muscle thin filament tropomyosin(GO:0005862)
0.0	0.1	GO:0031233	intrinsic component of external side of plasma membrane(GO:0031233)
0.0	0.2	GO:0030057	desmosome(GO:0030057)
0.0	0.0	GO:0014701	junctional sarcoplasmic reticulum membrane(GO:0014701)
0.0	0.0	GO:0045298	tubulin complex(GO:0045298)
0.0	0.1	GO:0005736	DNA-directed RNA polymerase I complex(GO:0005736)
0.0	0.1	GO:0005861	troponin complex(GO:0005861)
0.0	0.0	GO:0000176	nuclear exosome (RNase complex)(GO:0000176)
0.0	0.1	GO:0005697	telomerase holoenzyme complex(GO:0005697)
0.0	0.1	GO:0032588	trans-Golgi network membrane(GO:0032588)
0.0	0.9	GO:0030016	myofibril(GO:0030016)
0.0	0.0	GO:0070545	PeBoW complex(GO:0070545)
0.0	0.2	GO:0005811	lipid particle(GO:0005811)
0.0	0.1	GO:0005663	DNA replication factor C complex(GO:0005663)
0.0	0.0	GO:0016942	insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0004668	protein-arginine deiminase activity(GO:0004668)
0.1	0.2	GO:0051371	muscle alpha-actinin binding(GO:0051371)
0.1	0.2	GO:0004117	calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117)
0.1	0.2	GO:0005010	insulin-like growth factor-activated receptor activity(GO:0005010)
0.1	0.2	GO:0003873	6-phosphofructo-2-kinase activity(GO:0003873)
0.0	0.1	GO:0030215	semaphorin receptor binding(GO:0030215)
0.0	0.1	GO:0004995	tachykinin receptor activity(GO:0004995)
0.0	0.2	GO:0031545	procollagen-proline 4-dioxygenase activity(GO:0004656) peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.0	0.2	GO:0030618	transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0	0.1	GO:0005229	intracellular calcium activated chloride channel activity(GO:0005229)
0.0	0.3	GO:0017154	semaphorin receptor activity(GO:0017154)
0.0	0.2	GO:0008510	sodium:bicarbonate symporter activity(GO:0008510)
0.0	0.1	GO:0003680	AT DNA binding(GO:0003680)
0.0	0.2	GO:0048027	mRNA 5'-UTR binding(GO:0048027)
0.0	0.1	GO:0016901	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor(GO:0016901)
0.0	0.1	GO:0070052	collagen V binding(GO:0070052)
0.0	0.2	GO:0005007	fibroblast growth factor-activated receptor activity(GO:0005007)
0.0	0.1	GO:0005006	epidermal growth factor-activated receptor activity(GO:0005006)
0.0	0.1	GO:0004157	dihydropyrimidinase activity(GO:0004157)
0.0	0.1	GO:0005173	stem cell factor receptor binding(GO:0005173)
0.0	0.1	GO:0004720	protein-lysine 6-oxidase activity(GO:0004720)
0.0	0.0	GO:0008109	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0	0.3	GO:0047372	acylglycerol lipase activity(GO:0047372)
0.0	0.1	GO:0033743	peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.0	0.1	GO:0042808	obsolete neuronal Cdc2-like kinase binding(GO:0042808)
0.0	0.1	GO:0035514	DNA demethylase activity(GO:0035514) DNA-N1-methyladenine dioxygenase activity(GO:0043734)
0.0	0.1	GO:0015254	glycerol channel activity(GO:0015254)
0.0	0.1	GO:0015204	urea transmembrane transporter activity(GO:0015204)
0.0	0.1	GO:0004687	myosin light chain kinase activity(GO:0004687)
0.0	0.1	GO:0004103	choline kinase activity(GO:0004103)
0.0	0.1	GO:0036137	kynurenine-oxoglutarate transaminase activity(GO:0016212) kynurenine aminotransferase activity(GO:0036137)
0.0	0.1	GO:0005072	transforming growth factor beta receptor, cytoplasmic mediator activity(GO:0005072)
0.0	0.1	GO:0030297	transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.0	0.1	GO:0031957	very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0	0.1	GO:0002162	dystroglycan binding(GO:0002162)
0.0	0.1	GO:0070324	thyroid hormone binding(GO:0070324)
0.0	0.2	GO:0017166	vinculin binding(GO:0017166)
0.0	0.1	GO:0004791	thioredoxin-disulfide reductase activity(GO:0004791)
0.0	0.1	GO:0008475	procollagen-lysine 5-dioxygenase activity(GO:0008475)
0.0	0.1	GO:0015467	G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0	0.2	GO:0008191	metalloendopeptidase inhibitor activity(GO:0008191)
0.0	0.2	GO:0051378	serotonin binding(GO:0051378)
0.0	0.1	GO:0004523	RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.0	0.1	GO:0090482	vitamin transmembrane transporter activity(GO:0090482)
0.0	0.1	GO:0008253	5'-nucleotidase activity(GO:0008253)
0.0	0.1	GO:0001849	complement component C1q binding(GO:0001849)
0.0	0.1	GO:0005110	frizzled-2 binding(GO:0005110)
0.0	0.1	GO:0005432	calcium:sodium antiporter activity(GO:0005432)
0.0	0.1	GO:0017080	sodium channel regulator activity(GO:0017080)
0.0	0.1	GO:0008107	galactoside 2-alpha-L-fucosyltransferase activity(GO:0008107) alpha-(1,2)-fucosyltransferase activity(GO:0031127)
0.0	0.1	GO:0016215	stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215)
0.0	0.1	GO:0015277	kainate selective glutamate receptor activity(GO:0015277)
0.0	0.1	GO:0016361	activin receptor activity, type I(GO:0016361)
0.0	0.1	GO:0070644	vitamin D response element binding(GO:0070644)
0.0	0.1	GO:0008294	calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.0	0.1	GO:0001159	RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.0	0.1	GO:0048406	nerve growth factor binding(GO:0048406)
0.0	0.1	GO:0050501	hyaluronan synthase activity(GO:0050501)
0.0	0.1	GO:0004470	malic enzyme activity(GO:0004470)
0.0	0.1	GO:0097493	extracellular matrix constituent conferring elasticity(GO:0030023) structural molecule activity conferring elasticity(GO:0097493)
0.0	0.1	GO:0048018	receptor agonist activity(GO:0048018)
0.0	0.1	GO:0005332	gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.0	0.1	GO:0015016	[heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0	0.1	GO:0047760	butyrate-CoA ligase activity(GO:0047760)
0.0	0.1	GO:0004321	fatty-acyl-CoA synthase activity(GO:0004321)
0.0	0.1	GO:0042978	ornithine decarboxylase activator activity(GO:0042978)
0.0	0.2	GO:0048407	platelet-derived growth factor binding(GO:0048407)
0.0	0.1	GO:0005148	prolactin receptor binding(GO:0005148)
0.0	0.0	GO:0019215	intermediate filament binding(GO:0019215)
0.0	0.1	GO:0019211	phosphatase activator activity(GO:0019211)
0.0	0.0	GO:0004937	alpha1-adrenergic receptor activity(GO:0004937)
0.0	0.2	GO:0005523	tropomyosin binding(GO:0005523)
0.0	0.1	GO:0000832	inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832)
0.0	0.2	GO:0005355	glucose transmembrane transporter activity(GO:0005355)
0.0	0.1	GO:0050998	nitric-oxide synthase binding(GO:0050998)
0.0	0.0	GO:0043398	HLH domain binding(GO:0043398)
0.0	0.4	GO:0004181	metallocarboxypeptidase activity(GO:0004181)
0.0	0.0	GO:0034186	apolipoprotein A-I binding(GO:0034186)
0.0	0.0	GO:0050508	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.0	0.1	GO:0009374	biotin binding(GO:0009374)
0.0	0.1	GO:0004597	peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.0	0.1	GO:0019966	interleukin-1 binding(GO:0019966)
0.0	0.1	GO:0004128	cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.0	0.1	GO:0051380	norepinephrine binding(GO:0051380)
0.0	0.1	GO:0008503	benzodiazepine receptor activity(GO:0008503)
0.0	0.1	GO:0016724	ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0	0.0	GO:0004477	methenyltetrahydrofolate cyclohydrolase activity(GO:0004477)
0.0	0.1	GO:0070290	N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0	0.2	GO:0019894	kinesin binding(GO:0019894)
0.0	0.0	GO:0043008	ATP-dependent protein binding(GO:0043008)
0.0	0.1	GO:0046970	histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) histone deacetylase activity (H4-K16 specific)(GO:0034739) NAD-dependent histone deacetylase activity (H4-K16 specific)(GO:0046970)
0.0	0.3	GO:0005520	insulin-like growth factor binding(GO:0005520)
0.0	0.6	GO:0008009	chemokine activity(GO:0008009)
0.0	0.1	GO:0003689	DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0	0.3	GO:0050840	extracellular matrix binding(GO:0050840)
0.0	0.1	GO:0016018	cyclosporin A binding(GO:0016018)
0.0	0.0	GO:0070815	peptidyl-lysine 5-dioxygenase activity(GO:0070815)
0.0	0.0	GO:0008898	S-adenosylmethionine-homocysteine S-methyltransferase activity(GO:0008898)
0.0	0.1	GO:0016641	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641)
0.0	0.1	GO:0015280	ligand-gated sodium channel activity(GO:0015280)
0.0	0.1	GO:0070717	poly-purine tract binding(GO:0070717)
0.0	0.0	GO:0047623	AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0	0.0	GO:0004630	phospholipase D activity(GO:0004630)
0.0	0.1	GO:0004499	N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.0	0.0	GO:0033130	acetylcholine receptor binding(GO:0033130)
0.0	0.0	GO:0016647	oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.0	0.2	GO:0004653	polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0	0.0	GO:0000309	nicotinamide-nucleotide adenylyltransferase activity(GO:0000309) nicotinate-nucleotide adenylyltransferase activity(GO:0004515)
0.0	0.0	GO:0070700	transmembrane receptor protein serine/threonine kinase binding(GO:0070696) BMP receptor binding(GO:0070700)
0.0	0.1	GO:0043522	leucine zipper domain binding(GO:0043522)
0.0	0.1	GO:0070628	proteasome binding(GO:0070628)
0.0	0.0	GO:0050682	AF-2 domain binding(GO:0050682)
0.0	0.0	GO:0003829	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0003829)
0.0	0.0	GO:0001098	basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.0	0.5	GO:0004714	transmembrane receptor protein tyrosine kinase activity(GO:0004714)
0.0	0.0	GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.1	PID ECADHERIN KERATINOCYTE PATHWAY	E-cadherin signaling in keratinocytes
0.0	PID MYC PATHWAY	C-MYC pathway
0.4	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
0.6	PID ECADHERIN STABILIZATION PATHWAY	Stabilization and expansion of the E-cadherin adherens junction
0.0	PID FAS PATHWAY	FAS (CD95) signaling pathway
0.6	NABA COLLAGENS	Genes encoding collagen proteins
0.3	NABA BASEMENT MEMBRANES	Genes encoding structural components of basement membranes

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.1	REACTOME SHC1 EVENTS IN EGFR SIGNALING	Genes involved in SHC1 events in EGFR signaling
0.0	REACTOME PLC BETA MEDIATED EVENTS	Genes involved in PLC beta mediated events
0.4	REACTOME OTHER SEMAPHORIN INTERACTIONS	Genes involved in Other semaphorin interactions
0.6	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.2	REACTOME PURINE CATABOLISM	Genes involved in Purine catabolism
0.3	REACTOME SEROTONIN RECEPTORS	Genes involved in Serotonin receptors
0.2	REACTOME G2 M DNA DAMAGE CHECKPOINT	Genes involved in G2/M DNA damage checkpoint
0.1	REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION	Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.1	REACTOME ACTIVATION OF RAC	Genes involved in Activation of Rac
0.2	REACTOME TRYPTOPHAN CATABOLISM	Genes involved in Tryptophan catabolism
0.3	REACTOME CGMP EFFECTS	Genes involved in cGMP effects
0.1	REACTOME CRMPS IN SEMA3A SIGNALING	Genes involved in CRMPs in Sema3A signaling
0.8	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.2	REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS	Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.2	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.3	REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY	Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1	REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	Genes involved in Ionotropic activity of Kainate Receptors
0.3	REACTOME SIGNALING BY HIPPO	Genes involved in Signaling by Hippo
0.0	REACTOME PLATELET AGGREGATION PLUG FORMATION	Genes involved in Platelet Aggregation (Plug Formation)
0.1	REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE	Genes involved in Synthesis of PIPs at the late endosome membrane
0.0	REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY	Genes involved in Regulation of the Fanconi anemia pathway
0.2	REACTOME SHC1 EVENTS IN ERBB4 SIGNALING	Genes involved in SHC1 events in ERBB4 signaling
0.1	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
0.0	REACTOME ALPHA LINOLENIC ACID ALA METABOLISM	Genes involved in alpha-linolenic acid (ALA) metabolism
0.1	REACTOME ERKS ARE INACTIVATED	Genes involved in ERKs are inactivated
0.1	REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL	Genes involved in NF-kB is activated and signals survival
0.2	REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Glutamate Neurotransmitter Release Cycle
0.1	REACTOME GAP JUNCTION DEGRADATION	Genes involved in Gap junction degradation
0.3	REACTOME HS GAG BIOSYNTHESIS	Genes involved in HS-GAG biosynthesis
0.1	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.1	REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS	Genes involved in Facilitative Na+-independent glucose transporters