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ENCODE: H3K4me1 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for ONECUT1

Z-value: 1.29

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Transcription factors associated with ONECUT1

Gene Symbol	Gene ID	Gene Info
ONECUT1 Ensembl NCBI GeneCards UniProt	ENSG00000169856.7	ONECUT1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
ONECUT1	chr15_53081990_53082166	131	0.977500	-0.68	4.3e-02	Click!
ONECUT1	chr15_53075384_53075631	2127	0.425505	0.61	7.9e-02	Click!
ONECUT1	chr15_53081158_53081309	976	0.680244	-0.58	1.0e-01	Click!
ONECUT1	chr15_53075819_53076008	2533	0.387690	0.57	1.1e-01	Click!
ONECUT1	chr15_53494946_53495097	412812	0.006931	-0.55	1.2e-01	Click!

Activity of the ONECUT1 motif across conditions

Conditions sorted by the z-value of the ONECUT1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr3_71754237_71754523	0.44	EIF4E3	eukaryotic translation initiation factor 4E family member 3	20146	0.21
chr6_46934061_46934212	0.38	GPR116	G protein-coupled receptor 116	11456	0.23
chr11_128356295_128356446	0.38	ETS1	v-ets avian erythroblastosis virus E26 oncogene homolog 1	18919	0.24
chr18_67621349_67621587	0.36	CD226	CD226 molecule	2438	0.41
chr1_172350739_172351257	0.36	DNM3	dynamin 3	2840	0.24
chr2_69703322_69703473	0.36	NFU1	NFU1 iron-sulfur cluster scaffold homolog (S. cerevisiae)	38637	0.14
chr2_204607032_204607284	0.35	ENSG00000211573	.	22363	0.19
chr20_51025367_51025552	0.35	ZFP64	ZFP64 zinc finger protein	216934	0.02
chr1_206752443_206752919	0.35	RASSF5	Ras association (RalGDS/AF-6) domain family member 5	22188	0.14
chr15_91129425_91129576	0.34	CRTC3	CREB regulated transcription coactivator 3	7445	0.17
chr7_114577295_114577446	0.34	MDFIC	MyoD family inhibitor domain containing	3446	0.39
chr4_187853574_187853725	0.33	ENSG00000252382	.	75039	0.13
chr15_33401071_33401222	0.33	FMN1	formin 1	40783	0.2
chr11_117819899_117820198	0.32	TMPRSS13	transmembrane protease, serine 13	19874	0.16
chrX_53693571_53693722	0.32	HUWE1	HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase	17468	0.24
chr17_38779166_38779543	0.32	SMARCE1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1	9188	0.15
chr15_60998831_60998982	0.32	RP11-219B17.2		25080	0.18
chr1_67609394_67609545	0.31	C1orf141	chromosome 1 open reading frame 141	8809	0.17
chrX_117670481_117670691	0.31	ENSG00000206862	.	32892	0.18
chr14_75301018_75301169	0.31	RP11-316E14.6		9634	0.14
chr3_11665619_11665770	0.31	VGLL4	vestigial like 4 (Drosophila)	3186	0.26
chr12_110385989_110386149	0.31	TCHP	trichoplein, keratin filament binding	47655	0.1
chr11_18652208_18652359	0.31	SPTY2D1	SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae)	3757	0.19
chr15_25682392_25682786	0.31	UBE3A	ubiquitin protein ligase E3A	1099	0.43
chr13_50667366_50667517	0.31	DLEU1	deleted in lymphocytic leukemia 1 (non-protein coding)	11134	0.19
chr12_662501_663191	0.31	B4GALNT3	beta-1,4-N-acetyl-galactosaminyl transferase 3	10547	0.16
chr1_169596848_169596999	0.30	SELP	selectin P (granule membrane protein 140kDa, antigen CD62)	2391	0.32
chr1_24840661_24840812	0.30	RCAN3	RCAN family member 3	74	0.97
chr2_225849112_225849337	0.30	ENSG00000263828	.	26033	0.23
chr15_89171782_89171992	0.30	AEN	apoptosis enhancing nuclease	7286	0.15
chr1_161034126_161034311	0.30	AL591806.1	Uncharacterized protein	1437	0.2
chr2_143917081_143917249	0.29	RP11-190J23.1		12576	0.25
chr15_38843563_38843770	0.29	RASGRP1	RAS guanyl releasing protein 1 (calcium and DAG-regulated)	8617	0.18
chr14_50447166_50447546	0.28	C14orf182	chromosome 14 open reading frame 182	26882	0.15
chr14_32548210_32548608	0.28	ARHGAP5	Rho GTPase activating protein 5	972	0.55
chr10_115607454_115607605	0.28	DCLRE1A	DNA cross-link repair 1A	6330	0.18
chr15_33384160_33384311	0.28	FMN1	formin 1	23872	0.25
chr2_85085633_85085887	0.28	TRABD2A	TraB domain containing 2A	22446	0.18
chr17_65833184_65833335	0.28	ENSG00000265086	.	6802	0.18
chr19_32839685_32839836	0.28	ZNF507	zinc finger protein 507	3135	0.24
chr10_92962405_92962639	0.28	PCGF5	polycomb group ring finger 5	17386	0.29
chr13_41011930_41012431	0.28	ENSG00000252812	.	30603	0.23
chr2_205814595_205814746	0.28	PARD3B	par-3 family cell polarity regulator beta	403947	0.01
chr9_4546909_4547086	0.28	SLC1A1	solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1	25338	0.21
chr6_150020862_150021104	0.28	LATS1	large tumor suppressor kinase 1	2507	0.23
chr15_26057779_26057955	0.27	ENSG00000199214	.	5263	0.22
chr6_142866253_142866404	0.27	GPR126	G protein-coupled receptor 126	154879	0.04
chr12_21605567_21605718	0.27	PYROXD1	pyridine nucleotide-disulphide oxidoreductase domain 1	14793	0.17
chr1_24863399_24863781	0.27	ENSG00000266551	.	7386	0.17
chr14_75334182_75334460	0.27	PROX2	prospero homeobox 2	3784	0.17
chr4_27004622_27004939	0.27	STIM2	stromal interaction molecule 2	158	0.98
chr13_96295415_96295566	0.27	DZIP1	DAZ interacting zinc finger protein 1	27	0.98
chr2_181909294_181909445	0.27	UBE2E3	ubiquitin-conjugating enzyme E2E 3	62619	0.14
chr11_114053249_114053976	0.27	NNMT	nicotinamide N-methyltransferase	74941	0.09
chr10_86091819_86091970	0.27	CCSER2	coiled-coil serine-rich protein 2	3475	0.31
chr17_76113070_76113221	0.27	ENSG00000204282	.	5265	0.13
chr7_50364049_50364214	0.26	IKZF1	IKAROS family zinc finger 1 (Ikaros)	3114	0.37
chr12_102188801_102188952	0.26	ENSG00000222932	.	1404	0.27
chr2_179901450_179901601	0.26	CCDC141	coiled-coil domain containing 141	13261	0.21
chr9_137193267_137193522	0.26	RXRA	retinoid X receptor, alpha	25032	0.22
chr11_104668978_104669231	0.26	CASP12	caspase 12 (gene/pseudogene)	100037	0.07
chr3_43518340_43518545	0.26	ENSG00000251811	.	4473	0.29
chr1_112020337_112020708	0.26	C1orf162	chromosome 1 open reading frame 162	4031	0.12
chr12_47788688_47788839	0.26	ENSG00000264906	.	30711	0.19
chrX_135738263_135738414	0.26	CD40LG	CD40 ligand	7952	0.18
chr1_12234665_12234953	0.26	TNFRSF1B	tumor necrosis factor receptor superfamily, member 1B	7749	0.16
chr10_28507230_28507496	0.26	MPP7	membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)	20303	0.25
chr8_125654530_125654866	0.26	RP11-532M24.1		62826	0.11
chr2_182381274_182381425	0.26	ITGA4	integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)	59194	0.14
chr2_136886605_136886811	0.26	CXCR4	chemokine (C-X-C motif) receptor 4	10973	0.28
chr4_109036061_109036413	0.26	LEF1	lymphoid enhancer-binding factor 1	51220	0.14
chr11_108120449_108120621	0.26	AP001925.1		15945	0.15
chr2_198896763_198896914	0.26	PLCL1	phospholipase C-like 1	51698	0.18
chr8_66701143_66701322	0.26	PDE7A	phosphodiesterase 7A	87	0.98
chr2_202113259_202113410	0.26	CASP8	caspase 8, apoptosis-related cysteine peptidase	9369	0.19
chr20_8125317_8125709	0.26	PLCB1	phospholipase C, beta 1 (phosphoinositide-specific)	12211	0.27
chr3_71142898_71143049	0.26	FOXP1	forkhead box P1	28055	0.26
chr1_84630834_84631034	0.26	PRKACB	protein kinase, cAMP-dependent, catalytic, beta	285	0.94
chr10_104513769_104513920	0.25	WBP1L	WW domain binding protein 1-like	10117	0.15
chr12_92692622_92693037	0.25	RP11-693J15.4		122478	0.05
chr19_49164522_49164784	0.25	NTN5	netrin 5	11611	0.08
chr8_20351774_20351998	0.25	ENSG00000251944	.	120551	0.06
chr1_116933196_116933468	0.25	AL136376.1	Uncharacterized protein	6614	0.16
chr2_46978789_46978940	0.25	SOCS5	suppressor of cytokine signaling 5	52538	0.11
chr1_147101695_147101978	0.25	ACP6	acid phosphatase 6, lysophosphatidic	29280	0.19
chr6_135356178_135356329	0.25	HBS1L	HBS1-like (S. cerevisiae)	7919	0.22
chr8_2080105_2080333	0.25	MYOM2	myomesin 2	87035	0.1
chr12_109538291_109538505	0.25	UNG	uracil-DNA glycosylase	2475	0.18
chr11_3401052_3401203	0.25	ZNF195	zinc finger protein 195	679	0.64
chr6_167531770_167531921	0.25	CCR6	chemokine (C-C motif) receptor 6	4412	0.22
chr14_106620952_106621103	0.25	IGHVII-15-1	immunoglobulin heavy variable (II)-15-1 (pseudogene)	538	0.39
chr4_95365853_95366004	0.25	PDLIM5	PDZ and LIM domain 5	7109	0.32
chr10_90585510_90585661	0.25	LIPM	lipase, family member M	22880	0.15
chr17_28723594_28723745	0.25	CPD	carboxypeptidase D	16415	0.15
chr12_56496025_56496345	0.25	RP11-603J24.9	Uncharacterized protein	1070	0.22
chr3_58481037_58481337	0.25	KCTD6	potassium channel tetramerization domain containing 6	1545	0.38
chr5_171387448_171387599	0.24	FBXW11	F-box and WD repeat domain containing 11	17237	0.25
chr7_36084778_36084929	0.24	PP13004		33841	0.18
chr6_40608172_40608323	0.24	LRFN2	leucine rich repeat and fibronectin type III domain containing 2	53043	0.16
chr15_87159734_87160062	0.24	RP11-182L7.1		14469	0.3
chr17_1336289_1336440	0.24	RP11-818O24.3		8294	0.15
chr13_32347129_32347280	0.24	RXFP2	relaxin/insulin-like family peptide receptor 2	33525	0.24
chr21_47788624_47788796	0.24	PCNT	pericentrin	44674	0.1
chr8_141641731_141641895	0.24	AGO2	argonaute RISC catalytic component 2	3832	0.28
chr8_119821666_119821817	0.24	TNFRSF11B	tumor necrosis factor receptor superfamily, member 11b	142698	0.05
chr14_98657577_98657728	0.24	ENSG00000222066	.	140435	0.05
chr2_201331001_201331184	0.24	SPATS2L	spermatogenesis associated, serine-rich 2-like	25720	0.16
chr2_12874585_12874736	0.24	ENSG00000264370	.	2833	0.34
chr7_158936629_158936995	0.24	VIPR2	vasoactive intestinal peptide receptor 2	732	0.8
chr16_3623403_3623748	0.24	NLRC3	NLR family, CARD domain containing 3	3817	0.17
chr15_64861726_64861912	0.24	ZNF609	zinc finger protein 609	70328	0.07
chr6_159635157_159635308	0.24	FNDC1	fibronectin type III domain containing 1	16753	0.2
chr7_6546712_6546863	0.24	KDELR2	KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2	22914	0.11
chr5_138641580_138641731	0.24	MATR3	matrin 3	2129	0.19
chr12_40023474_40023652	0.24	C12orf40	chromosome 12 open reading frame 40	3578	0.29
chrX_149880583_149880734	0.24	MTMR1	myotubularin related protein 1	6491	0.3
chr6_510010_510533	0.24	RP1-20B11.2		13900	0.28
chr10_76346905_76347116	0.23	ENSG00000206756	.	35860	0.2
chr10_22028920_22029395	0.23	ENSG00000252634	.	45064	0.15
chr11_88579489_88579640	0.23	GRM5	glutamate receptor, metabotropic 5	200974	0.03
chr16_56226659_56226810	0.23	GNAO1	guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O	329	0.86
chr1_36611019_36611170	0.23	TRAPPC3	trafficking protein particle complex 3	3958	0.17
chr9_131337014_131337165	0.23	SPTAN1	spectrin, alpha, non-erythrocytic 1	22220	0.11
chr8_61449115_61449422	0.23	RP11-91I20.4		16327	0.21
chr8_81927272_81927636	0.23	PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	96849	0.08
chrX_48792186_48792645	0.23	PIM2	pim-2 oncogene	16114	0.08
chr14_21723112_21723263	0.23	HNRNPC	heterogeneous nuclear ribonucleoprotein C (C1/C2)	7649	0.18
chr3_18442605_18442786	0.23	RP11-158G18.1		8432	0.23
chr2_161185571_161185758	0.23	ENSG00000252465	.	67815	0.11
chr5_133462716_133463173	0.23	TCF7	transcription factor 7 (T-cell specific, HMG-box)	3635	0.26
chr1_198529109_198529554	0.23	ATP6V1G3	ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3	19256	0.26
chr12_92405753_92405904	0.23	C12orf79	chromosome 12 open reading frame 79	124969	0.05
chr11_4027933_4028182	0.23	STIM1	stromal interaction molecule 1	51922	0.12
chr20_37626778_37626929	0.23	DHX35	DEAH (Asp-Glu-Ala-His) box polypeptide 35	23663	0.19
chr10_33375837_33376051	0.23	ENSG00000263576	.	11620	0.23
chr2_46665689_46665843	0.23	ENSG00000241791	.	9884	0.2
chr14_75580842_75580993	0.23	NEK9	NIMA-related kinase 9	12826	0.13
chr2_240541514_240541718	0.23	AC079612.1	Uncharacterized protein; cDNA FLJ45964 fis, clone PLACE7014396	41621	0.19
chr15_61012596_61012899	0.23	ENSG00000212625	.	16221	0.2
chrX_41779550_41779701	0.23	ENSG00000251807	.	1023	0.57
chr14_22410532_22410683	0.23	ENSG00000222776	.	161822	0.03
chr9_4600854_4601005	0.23	SLC1A1	solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1	28594	0.17
chr2_203533655_203533879	0.23	FAM117B	family with sequence similarity 117, member B	33856	0.22
chr13_109061568_109062120	0.23	ENSG00000223177	.	108165	0.07
chr1_101748824_101749089	0.23	RP4-575N6.5		40242	0.14
chr1_78138076_78138256	0.23	ZZZ3	zinc finger, ZZ-type containing 3	10177	0.18
chr5_76029378_76029529	0.23	CTD-2384B11.2		17413	0.16
chr9_120309696_120309847	0.23	ASTN2	astrotactin 2	132423	0.05
chr11_98448599_98448750	0.23	CNTN5	contactin 5	443197	0.01
chr5_76940805_76940962	0.23	OTP	orthopedia homeobox	5370	0.26
chr13_51466339_51466600	0.23	RNASEH2B-AS1	RNASEH2B antisense RNA 1	691	0.7
chr5_78809205_78809433	0.23	HOMER1	homer homolog 1 (Drosophila)	702	0.74
chr22_42259302_42259453	0.22	RP5-821D11.7		28708	0.09
chr10_127934738_127934889	0.22	ENSG00000222740	.	100662	0.08
chr10_28855331_28855500	0.22	WAC	WW domain containing adaptor with coiled-coil	32363	0.16
chr6_128136934_128137193	0.22	THEMIS	thymocyte selection associated	85040	0.1
chr12_68176752_68176973	0.22	RP11-335O4.3		112163	0.07
chr10_121403059_121403303	0.22	BAG3	BCL2-associated athanogene 3	7701	0.23
chr5_32585003_32585380	0.22	SUB1	SUB1 homolog (S. cerevisiae)	414	0.9
chr16_67058607_67058758	0.22	CBFB	core-binding factor, beta subunit	4337	0.14
chr22_33138990_33139141	0.22	LL22NC01-116C6.1		40098	0.17
chr17_4078920_4079071	0.22	ENSG00000251812	.	10626	0.11
chr6_135888948_135889171	0.22	AHI1	Abelson helper integration site 1	70145	0.12
chr20_57233689_57233840	0.22	STX16	syntaxin 16	6701	0.17
chr11_128567905_128568246	0.22	SENCR	smooth muscle and endothelial cell enriched migration/differentiation-associated long non-coding RNA	2157	0.29
chr5_110567747_110567898	0.22	CAMK4	calcium/calmodulin-dependent protein kinase IV	8038	0.23
chr6_131534478_131534629	0.22	AKAP7	A kinase (PRKA) anchor protein 7	12586	0.3
chr7_127054523_127055019	0.22	ZNF800	zinc finger protein 800	17207	0.24
chr6_41020375_41020526	0.22	APOBEC2	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2	593	0.64
chr13_74629447_74629598	0.22	KLF12	Kruppel-like factor 12	60336	0.16
chr12_11856534_11856685	0.22	ETV6	ets variant 6	48826	0.17
chr3_101248750_101248908	0.22	SENP7	SUMO1/sentrin specific peptidase 7	16744	0.14
chr2_234898182_234898466	0.22	TRPM8	transient receptor potential cation channel, subfamily M, member 8	23062	0.19
chr2_158318490_158318649	0.22	CYTIP	cytohesin 1 interacting protein	17915	0.21
chr5_146173697_146173862	0.22	ENSG00000265875	.	59381	0.13
chr17_57904009_57904390	0.22	ENSG00000199004	.	14428	0.14
chr1_241798904_241799055	0.22	CHML	choroideremia-like (Rab escort protein 2)	253	0.92
chr11_33301093_33301244	0.22	HIPK3	homeodomain interacting protein kinase 3	21291	0.2
chr14_50453111_50453411	0.22	C14orf182	chromosome 14 open reading frame 182	20977	0.16
chr2_135037343_135037494	0.22	MGAT5	mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase	25588	0.23
chr4_54926277_54926428	0.22	AC110792.1	HCG2027126; Uncharacterized protein	861	0.57
chr2_204863439_204863670	0.22	ICOS	inducible T-cell co-stimulator	62051	0.15
chr14_52312481_52312871	0.22	GNG2	guanine nucleotide binding protein (G protein), gamma 2	1168	0.53
chr14_97926659_97926899	0.22	ENSG00000240730	.	69731	0.14
chr10_101419948_101420125	0.22	ENTPD7	ectonucleoside triphosphate diphosphohydrolase 7	773	0.57
chr12_117361072_117361223	0.22	FBXW8	F-box and WD repeat domain containing 8	12377	0.22
chr1_230308225_230308481	0.22	RP5-956O18.2		95876	0.07
chr3_18445696_18446011	0.22	RP11-158G18.1		5274	0.25
chr7_15498785_15499062	0.22	AGMO	alkylglycerol monooxygenase	93076	0.1
chr19_53178787_53178938	0.21	ZNF83	zinc finger protein 83	14765	0.14
chr11_114018411_114018569	0.21	ENSG00000221112	.	60839	0.12
chr10_93690175_93690326	0.21	BTAF1	BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa	6724	0.2
chr1_167612000_167612291	0.21	RP3-455J7.4		12234	0.19
chr10_1979822_1979973	0.21	ENSG00000252998	.	160464	0.04
chr6_26442991_26443142	0.21	BTN3A3	butyrophilin, subfamily 3, member A3	2280	0.18
chr1_42793424_42793575	0.21	FOXJ3	forkhead box J3	7137	0.2
chr8_100559197_100559348	0.21	ENSG00000216069	.	10183	0.16
chr1_200840277_200840712	0.21	GPR25	G protein-coupled receptor 25	1589	0.37
chr7_36830344_36830495	0.21	AC007349.7		48158	0.15
chr10_70377879_70378030	0.21	TET1	tet methylcytosine dioxygenase 1	57541	0.09

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of ONECUT1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.6	GO:1901339	activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.1	0.4	GO:0033152	immunoglobulin V(D)J recombination(GO:0033152)
0.1	0.2	GO:0030223	neutrophil differentiation(GO:0030223)
0.1	0.6	GO:0006198	cAMP catabolic process(GO:0006198)
0.1	0.1	GO:0045074	interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.1	0.5	GO:0002837	regulation of response to tumor cell(GO:0002834) positive regulation of response to tumor cell(GO:0002836) regulation of immune response to tumor cell(GO:0002837) positive regulation of immune response to tumor cell(GO:0002839)
0.1	0.2	GO:0002313	mature B cell differentiation involved in immune response(GO:0002313)
0.1	0.2	GO:0009138	pyrimidine nucleoside diphosphate metabolic process(GO:0009138)
0.1	0.3	GO:0050857	positive regulation of antigen receptor-mediated signaling pathway(GO:0050857)
0.1	0.2	GO:0046642	negative regulation of alpha-beta T cell proliferation(GO:0046642)
0.1	0.2	GO:0010867	positive regulation of triglyceride biosynthetic process(GO:0010867)
0.1	0.2	GO:0070779	D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.1	0.2	GO:0019276	UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.1	0.2	GO:0032236	obsolete positive regulation of calcium ion transport via store-operated calcium channel activity(GO:0032236)
0.1	0.2	GO:0010508	positive regulation of autophagy(GO:0010508)
0.0	0.1	GO:0060413	atrial septum development(GO:0003283) atrial septum morphogenesis(GO:0060413)
0.0	0.1	GO:0051834	evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.0	0.0	GO:0002513	tolerance induction to self antigen(GO:0002513)
0.0	0.0	GO:0051152	positive regulation of smooth muscle cell differentiation(GO:0051152)
0.0	0.1	GO:0048388	endosomal lumen acidification(GO:0048388)
0.0	0.0	GO:0021754	facial nucleus development(GO:0021754)
0.0	0.3	GO:0045066	regulatory T cell differentiation(GO:0045066)
0.0	0.0	GO:0002677	negative regulation of chronic inflammatory response(GO:0002677)
0.0	0.1	GO:0031223	auditory behavior(GO:0031223)
0.0	0.1	GO:0010957	negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137)
0.0	0.1	GO:0034135	regulation of toll-like receptor 2 signaling pathway(GO:0034135)
0.0	0.2	GO:0030910	olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.0	0.3	GO:0008653	lipopolysaccharide metabolic process(GO:0008653)
0.0	0.0	GO:0009189	deoxyribonucleoside diphosphate biosynthetic process(GO:0009189)
0.0	0.2	GO:0042989	sequestering of actin monomers(GO:0042989)
0.0	0.1	GO:0002248	connective tissue replacement involved in inflammatory response wound healing(GO:0002248) connective tissue replacement(GO:0097709)
0.0	0.3	GO:0032733	positive regulation of interleukin-10 production(GO:0032733)
0.0	0.2	GO:0032876	regulation of DNA endoreduplication(GO:0032875) negative regulation of DNA endoreduplication(GO:0032876) DNA endoreduplication(GO:0042023)
0.0	0.1	GO:0010572	positive regulation of platelet activation(GO:0010572)
0.0	0.4	GO:0043368	positive T cell selection(GO:0043368)
0.0	0.1	GO:0045722	positive regulation of gluconeogenesis(GO:0045722)
0.0	0.2	GO:0060023	soft palate development(GO:0060023)
0.0	0.1	GO:0016266	O-glycan processing(GO:0016266)
0.0	0.1	GO:0015864	pyrimidine nucleoside transport(GO:0015864)
0.0	0.2	GO:0016556	mRNA modification(GO:0016556)
0.0	0.0	GO:1904063	negative regulation of ion transmembrane transporter activity(GO:0032413) negative regulation of cation transmembrane transport(GO:1904063)
0.0	0.2	GO:0006346	methylation-dependent chromatin silencing(GO:0006346)
0.0	0.1	GO:0042661	regulation of mesodermal cell fate specification(GO:0042661) regulation of mesoderm development(GO:2000380)
0.0	0.2	GO:0031498	nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.0	0.1	GO:1901797	negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518) negative regulation of signal transduction by p53 class mediator(GO:1901797)
0.0	0.2	GO:0000381	regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0	0.2	GO:0051926	negative regulation of calcium ion transport(GO:0051926)
0.0	0.2	GO:0002063	chondrocyte development(GO:0002063)
0.0	0.1	GO:0060049	regulation of protein glycosylation(GO:0060049)
0.0	0.1	GO:0010587	miRNA metabolic process(GO:0010586) miRNA catabolic process(GO:0010587)
0.0	0.1	GO:0070634	transepithelial ammonium transport(GO:0070634)
0.0	0.1	GO:0014834	skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration(GO:0014834)
0.0	0.1	GO:0007343	egg activation(GO:0007343)
0.0	0.1	GO:0036072	intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.0	0.2	GO:0097354	protein prenylation(GO:0018342) prenylation(GO:0097354)
0.0	0.1	GO:0045898	regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0	0.1	GO:0048096	chromatin-mediated maintenance of transcription(GO:0048096)
0.0	0.1	GO:0022614	membrane to membrane docking(GO:0022614)
0.0	0.2	GO:0045648	positive regulation of erythrocyte differentiation(GO:0045648)
0.0	0.1	GO:0015959	diadenosine polyphosphate metabolic process(GO:0015959)
0.0	0.0	GO:0010040	response to iron(II) ion(GO:0010040)
0.0	0.1	GO:0006552	leucine catabolic process(GO:0006552)
0.0	0.1	GO:0001672	regulation of chromatin assembly or disassembly(GO:0001672)
0.0	0.1	GO:0032410	negative regulation of transporter activity(GO:0032410)
0.0	0.1	GO:0030388	fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0	0.0	GO:0044803	multi-organism membrane organization(GO:0044803)
0.0	0.1	GO:0007352	zygotic specification of dorsal/ventral axis(GO:0007352)
0.0	0.1	GO:0080111	DNA demethylation(GO:0080111)
0.0	0.1	GO:0048024	regulation of mRNA splicing, via spliceosome(GO:0048024)
0.0	0.1	GO:0007406	negative regulation of neuroblast proliferation(GO:0007406) negative regulation of neural precursor cell proliferation(GO:2000178)
0.0	0.0	GO:0009786	regulation of asymmetric cell division(GO:0009786)
0.0	0.1	GO:0060528	secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.0	0.1	GO:0006772	thiamine metabolic process(GO:0006772)
0.0	0.1	GO:0043653	mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.0	0.0	GO:0060596	mammary placode formation(GO:0060596)
0.0	0.0	GO:0030011	maintenance of cell polarity(GO:0030011)
0.0	0.1	GO:0006498	N-terminal protein lipidation(GO:0006498)
0.0	0.0	GO:0045654	positive regulation of megakaryocyte differentiation(GO:0045654) positive regulation of hematopoietic progenitor cell differentiation(GO:1901534)
0.0	0.1	GO:0045948	positive regulation of translational initiation(GO:0045948)
0.0	0.1	GO:0006975	DNA damage induced protein phosphorylation(GO:0006975)
0.0	0.1	GO:0032525	somite rostral/caudal axis specification(GO:0032525)
0.0	0.0	GO:0048670	regulation of collateral sprouting(GO:0048670)
0.0	0.1	GO:0045601	regulation of endothelial cell differentiation(GO:0045601)
0.0	0.1	GO:0007256	activation of JNKK activity(GO:0007256)
0.0	0.0	GO:0002874	regulation of chronic inflammatory response to antigenic stimulus(GO:0002874)
0.0	0.2	GO:0048843	negative regulation of axon extension involved in axon guidance(GO:0048843)
0.0	0.1	GO:0060123	regulation of growth hormone secretion(GO:0060123)
0.0	0.2	GO:0033631	cell-cell adhesion mediated by integrin(GO:0033631)
0.0	0.1	GO:0007008	outer mitochondrial membrane organization(GO:0007008) protein import into mitochondrial outer membrane(GO:0045040)
0.0	0.1	GO:0060662	tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662)
0.0	0.0	GO:0048304	positive regulation of isotype switching to IgG isotypes(GO:0048304)
0.0	0.1	GO:0035583	sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.0	0.2	GO:0051828	entry into host cell(GO:0030260) entry into host(GO:0044409) entry into cell of other organism involved in symbiotic interaction(GO:0051806) entry into other organism involved in symbiotic interaction(GO:0051828)
0.0	0.0	GO:0006927	obsolete transformed cell apoptotic process(GO:0006927)
0.0	0.1	GO:0032790	ribosome disassembly(GO:0032790)
0.0	0.1	GO:0006685	sphingomyelin catabolic process(GO:0006685)
0.0	0.0	GO:0032776	DNA methylation on cytosine(GO:0032776) C-5 methylation of cytosine(GO:0090116)
0.0	0.1	GO:0048535	lymph node development(GO:0048535)
0.0	0.0	GO:0002634	regulation of germinal center formation(GO:0002634)
0.0	0.1	GO:0008356	asymmetric cell division(GO:0008356)
0.0	0.1	GO:0021913	regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913)
0.0	0.1	GO:0006089	lactate metabolic process(GO:0006089)
0.0	0.2	GO:0070536	protein K63-linked deubiquitination(GO:0070536)
0.0	0.1	GO:0006104	succinyl-CoA metabolic process(GO:0006104)
0.0	0.1	GO:0006538	glutamate catabolic process(GO:0006538)
0.0	0.1	GO:0006032	chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.0	0.1	GO:0006269	DNA replication, synthesis of RNA primer(GO:0006269)
0.0	0.0	GO:0051461	corticotropin secretion(GO:0051458) regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461)
0.0	0.1	GO:0060391	positive regulation of SMAD protein import into nucleus(GO:0060391)
0.0	0.2	GO:0016578	histone deubiquitination(GO:0016578)
0.0	0.0	GO:0071502	cellular response to temperature stimulus(GO:0071502)
0.0	0.0	GO:0043578	nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0	0.1	GO:0006422	aspartyl-tRNA aminoacylation(GO:0006422)
0.0	0.2	GO:0034199	activation of protein kinase A activity(GO:0034199)
0.0	0.0	GO:0010815	bradykinin catabolic process(GO:0010815)
0.0	0.0	GO:0043117	positive regulation of vascular permeability(GO:0043117)
0.0	0.0	GO:0051533	positive regulation of NFAT protein import into nucleus(GO:0051533)
0.0	0.0	GO:0050955	thermoception(GO:0050955)
0.0	0.1	GO:0045078	positive regulation of interferon-gamma biosynthetic process(GO:0045078)
0.0	0.1	GO:0060770	negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770)
0.0	0.3	GO:0030838	positive regulation of actin filament polymerization(GO:0030838)
0.0	0.0	GO:0046100	hypoxanthine metabolic process(GO:0046100)
0.0	0.0	GO:0072179	nephric duct formation(GO:0072179)
0.0	0.1	GO:0060678	dichotomous subdivision of terminal units involved in ureteric bud branching(GO:0060678)
0.0	0.0	GO:0002523	leukocyte migration involved in inflammatory response(GO:0002523)
0.0	0.1	GO:0033962	cytoplasmic mRNA processing body assembly(GO:0033962)
0.0	0.0	GO:0030259	lipid glycosylation(GO:0030259)
0.0	0.0	GO:0000733	DNA strand renaturation(GO:0000733)
0.0	0.0	GO:0048263	determination of dorsal identity(GO:0048263)
0.0	0.1	GO:0021535	cell migration in hindbrain(GO:0021535)
0.0	0.0	GO:0001996	positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996)
0.0	0.3	GO:0050690	regulation of defense response to virus by virus(GO:0050690)
0.0	0.0	GO:0031935	regulation of chromatin silencing(GO:0031935) negative regulation of chromatin silencing(GO:0031936)
0.0	0.0	GO:0090286	cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.0	0.0	GO:0070682	proteasome regulatory particle assembly(GO:0070682)
0.0	0.1	GO:0007095	mitotic G2 DNA damage checkpoint(GO:0007095)
0.0	0.0	GO:0006922	obsolete cleavage of lamin involved in execution phase of apoptosis(GO:0006922)
0.0	0.0	GO:0010792	DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792) double-strand break repair via single-strand annealing(GO:0045002)
0.0	0.1	GO:0006688	glycosphingolipid biosynthetic process(GO:0006688)
0.0	0.0	GO:0021978	telencephalon regionalization(GO:0021978)
0.0	0.1	GO:0009312	oligosaccharide biosynthetic process(GO:0009312)
0.0	0.0	GO:0035455	response to interferon-alpha(GO:0035455)
0.0	0.0	GO:0042996	regulation of Golgi to plasma membrane protein transport(GO:0042996)
0.0	0.0	GO:0015705	iodide transport(GO:0015705)
0.0	0.0	GO:0017182	peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.0	0.1	GO:0021854	hypothalamus development(GO:0021854)
0.0	0.0	GO:0042510	regulation of tyrosine phosphorylation of Stat1 protein(GO:0042510) positive regulation of tyrosine phosphorylation of Stat1 protein(GO:0042511)
0.0	0.0	GO:0030505	inorganic diphosphate transport(GO:0030505)
0.0	0.0	GO:0070933	histone H3 deacetylation(GO:0070932) histone H4 deacetylation(GO:0070933)
0.0	0.0	GO:0019255	glucose 1-phosphate metabolic process(GO:0019255)
0.0	0.0	GO:0032914	positive regulation of transforming growth factor beta1 production(GO:0032914)
0.0	0.0	GO:0048630	skeletal muscle tissue growth(GO:0048630)
0.0	0.0	GO:0009048	dosage compensation by inactivation of X chromosome(GO:0009048)
0.0	0.0	GO:0002507	tolerance induction(GO:0002507)
0.0	0.0	GO:0051305	chromosome movement towards spindle pole(GO:0051305)
0.0	0.0	GO:0022038	corpus callosum development(GO:0022038)
0.0	0.1	GO:0018027	peptidyl-lysine dimethylation(GO:0018027)
0.0	0.1	GO:0019885	antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.0	0.0	GO:0007207	phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.0	0.0	GO:0045875	negative regulation of sister chromatid cohesion(GO:0045875)
0.0	0.1	GO:0006477	protein sulfation(GO:0006477)
0.0	0.0	GO:0051182	coenzyme transport(GO:0051182)
0.0	0.0	GO:0021894	interneuron migration from the subpallium to the cortex(GO:0021830) cerebral cortex GABAergic interneuron migration(GO:0021853) cerebral cortex GABAergic interneuron development(GO:0021894) interneuron migration(GO:1904936)
0.0	0.0	GO:0021571	rhombomere 5 development(GO:0021571)
0.0	0.0	GO:0006642	triglyceride mobilization(GO:0006642)
0.0	0.0	GO:0000729	DNA double-strand break processing(GO:0000729)
0.0	0.0	GO:0072600	protein targeting to Golgi(GO:0000042) establishment of protein localization to Golgi(GO:0072600)
0.0	0.1	GO:0060039	pericardium development(GO:0060039)
0.0	0.0	GO:0002691	regulation of cellular extravasation(GO:0002691)
0.0	0.0	GO:0010989	negative regulation of low-density lipoprotein particle clearance(GO:0010989)
0.0	0.1	GO:0043268	positive regulation of potassium ion transport(GO:0043268)
0.0	0.0	GO:0032543	mitochondrial translation(GO:0032543)
0.0	0.0	GO:0033147	negative regulation of intracellular estrogen receptor signaling pathway(GO:0033147)
0.0	0.1	GO:0006734	NADH metabolic process(GO:0006734)
0.0	0.1	GO:0040015	negative regulation of multicellular organism growth(GO:0040015)
0.0	0.1	GO:0051775	response to redox state(GO:0051775)
0.0	0.0	GO:0032455	nerve growth factor processing(GO:0032455)
0.0	0.1	GO:0045003	DNA recombinase assembly(GO:0000730) double-strand break repair via synthesis-dependent strand annealing(GO:0045003)
0.0	0.1	GO:0042987	amyloid precursor protein catabolic process(GO:0042987)
0.0	0.2	GO:0042462	eye photoreceptor cell development(GO:0042462)
0.0	0.1	GO:0044091	membrane biogenesis(GO:0044091)

Gene overrepresentation in cellular component category:

Total log-likelihood	Term	Description
0.1	GO:0070022	transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.2	GO:0005658	alpha DNA polymerase:primase complex(GO:0005658)
0.1	GO:0005945	6-phosphofructokinase complex(GO:0005945)
0.4	GO:0033276	transcription factor TFTC complex(GO:0033276)
0.1	GO:0042105	alpha-beta T cell receptor complex(GO:0042105)
0.1	GO:0031932	TORC2 complex(GO:0031932)
0.1	GO:0032444	activin responsive factor complex(GO:0032444)
0.2	GO:0005697	telomerase holoenzyme complex(GO:0005697)
0.3	GO:0010494	cytoplasmic stress granule(GO:0010494)
0.2	GO:0001891	phagocytic cup(GO:0001891)
0.1	GO:0000153	cytoplasmic ubiquitin ligase complex(GO:0000153)
0.1	GO:0031235	intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0	GO:0033270	paranode region of axon(GO:0033270)
0.1	GO:0014731	spectrin-associated cytoskeleton(GO:0014731)
0.1	GO:0000137	Golgi cis cisterna(GO:0000137)
0.1	GO:0031464	Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.1	GO:0044224	juxtaparanode region of axon(GO:0044224)
0.1	GO:0019907	cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
0.1	GO:0072357	PTW/PP1 phosphatase complex(GO:0072357)
0.1	GO:0031264	death-inducing signaling complex(GO:0031264)
0.2	GO:0005952	cAMP-dependent protein kinase complex(GO:0005952)
0.1	GO:0000506	glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.1	GO:0032045	guanyl-nucleotide exchange factor complex(GO:0032045)
0.1	GO:0032777	Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0	GO:0031205	endoplasmic reticulum Sec complex(GO:0031205)
0.1	GO:0034992	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.1	GO:0034464	BBSome(GO:0034464)
0.0	GO:0070852	cell body fiber(GO:0070852)
0.1	GO:0005826	actomyosin contractile ring(GO:0005826)
0.1	GO:0016942	insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454)
0.1	GO:0043190	ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.1	GO:0030121	AP-1 adaptor complex(GO:0030121)
0.1	GO:0034518	mRNA cap binding complex(GO:0005845) RNA cap binding complex(GO:0034518)
0.3	GO:0019005	SCF ubiquitin ligase complex(GO:0019005)
0.1	GO:0045120	pronucleus(GO:0045120)
0.0	GO:0000164	protein phosphatase type 1 complex(GO:0000164)
0.0	GO:0005900	oncostatin-M receptor complex(GO:0005900)
0.1	GO:0031105	septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.0	GO:0016593	Cdc73/Paf1 complex(GO:0016593)
0.0	GO:0005954	calcium- and calmodulin-dependent protein kinase complex(GO:0005954)
0.1	GO:0043034	costamere(GO:0043034)
0.0	GO:0030008	TRAPP complex(GO:0030008)
0.0	GO:0005736	DNA-directed RNA polymerase I complex(GO:0005736)
0.1	GO:0030056	hemidesmosome(GO:0030056)
0.3	GO:0005626	obsolete insoluble fraction(GO:0005626)
0.3	GO:0032587	ruffle membrane(GO:0032587)
0.0	GO:0033185	mannosyltransferase complex(GO:0031501) dolichol-phosphate-mannose synthase complex(GO:0033185)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0031628	opioid receptor binding(GO:0031628)
0.1	0.2	GO:0003829	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0003829)
0.1	0.2	GO:0003836	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.1	0.3	GO:0031013	troponin I binding(GO:0031013)
0.1	0.2	GO:0030284	estrogen receptor activity(GO:0030284)
0.0	0.1	GO:0042910	xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.0	0.2	GO:0035252	UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285)
0.0	0.1	GO:0004719	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.0	0.3	GO:0016494	C-X-C chemokine receptor activity(GO:0016494)
0.0	0.1	GO:0004999	vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.0	0.3	GO:0008318	protein prenyltransferase activity(GO:0008318)
0.0	0.1	GO:0047756	chondroitin 4-sulfotransferase activity(GO:0047756)
0.0	0.3	GO:0004691	cAMP-dependent protein kinase activity(GO:0004691)
0.0	0.1	GO:0004911	interleukin-2 receptor activity(GO:0004911)
0.0	0.2	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.0	0.3	GO:0030332	cyclin binding(GO:0030332)
0.0	0.5	GO:0005246	calcium channel regulator activity(GO:0005246)
0.0	0.1	GO:0003872	6-phosphofructokinase activity(GO:0003872)
0.0	0.1	GO:0047238	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.0	0.2	GO:0003828	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0	0.5	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0	0.2	GO:0005314	high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.0	0.3	GO:0034593	phosphatidylinositol bisphosphate phosphatase activity(GO:0034593)
0.0	0.2	GO:0030618	transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0	0.1	GO:0033691	sialic acid binding(GO:0033691)
0.0	0.3	GO:0016493	C-C chemokine receptor activity(GO:0016493)
0.0	0.1	GO:0004677	DNA-dependent protein kinase activity(GO:0004677)
0.0	0.1	GO:0019911	structural constituent of myelin sheath(GO:0019911)
0.0	0.1	GO:0005134	interleukin-2 receptor binding(GO:0005134)
0.0	0.1	GO:0004351	glutamate decarboxylase activity(GO:0004351)
0.0	0.1	GO:0019870	potassium channel inhibitor activity(GO:0019870)
0.0	0.1	GO:0030911	TPR domain binding(GO:0030911)
0.0	0.1	GO:0015379	potassium:chloride symporter activity(GO:0015379)
0.0	0.1	GO:0015377	cation:chloride symporter activity(GO:0015377)
0.0	0.1	GO:0035198	miRNA binding(GO:0035198)
0.0	0.5	GO:0045028	G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0	0.1	GO:0043141	ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.0	0.3	GO:0005095	GTPase inhibitor activity(GO:0005095)
0.0	0.0	GO:0004690	cyclic nucleotide-dependent protein kinase activity(GO:0004690)
0.0	0.1	GO:0003886	DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0	0.1	GO:0004126	cytidine deaminase activity(GO:0004126)
0.0	0.1	GO:0004803	transposase activity(GO:0004803)
0.0	0.2	GO:0004467	long-chain fatty acid-CoA ligase activity(GO:0004467)
0.0	0.2	GO:0005021	vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0	0.1	GO:0070644	vitamin D response element binding(GO:0070644)
0.0	0.1	GO:0008649	rRNA methyltransferase activity(GO:0008649)
0.0	0.1	GO:0050815	phosphoserine binding(GO:0050815)
0.0	0.1	GO:0048018	receptor agonist activity(GO:0048018)
0.0	0.1	GO:0008568	microtubule-severing ATPase activity(GO:0008568)
0.0	0.2	GO:0070742	C2H2 zinc finger domain binding(GO:0070742)
0.0	0.2	GO:0005251	delayed rectifier potassium channel activity(GO:0005251)
0.0	0.1	GO:0005176	ErbB-2 class receptor binding(GO:0005176)
0.0	0.0	GO:0043008	ATP-dependent protein binding(GO:0043008)
0.0	0.1	GO:0004774	succinate-CoA ligase activity(GO:0004774)
0.0	0.1	GO:0097506	uracil DNA N-glycosylase activity(GO:0004844) deaminated base DNA N-glycosylase activity(GO:0097506)
0.0	0.4	GO:0005164	tumor necrosis factor receptor binding(GO:0005164)
0.0	0.1	GO:0004465	lipoprotein lipase activity(GO:0004465)
0.0	0.1	GO:0097493	extracellular matrix constituent conferring elasticity(GO:0030023) structural molecule activity conferring elasticity(GO:0097493)
0.0	0.1	GO:0004568	chitinase activity(GO:0004568)
0.0	0.1	GO:0016309	1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0	0.0	GO:0003726	double-stranded RNA adenosine deaminase activity(GO:0003726)
0.0	0.1	GO:0005072	transforming growth factor beta receptor, cytoplasmic mediator activity(GO:0005072)
0.0	0.1	GO:0046923	ER retention sequence binding(GO:0046923)
0.0	0.1	GO:0030507	spectrin binding(GO:0030507)
0.0	0.1	GO:0004176	ATP-dependent peptidase activity(GO:0004176)
0.0	0.1	GO:0055103	ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106)
0.0	0.2	GO:0005031	tumor necrosis factor-activated receptor activity(GO:0005031)
0.0	0.1	GO:0004767	sphingomyelin phosphodiesterase activity(GO:0004767)
0.0	0.1	GO:0004815	aspartate-tRNA ligase activity(GO:0004815)
0.0	0.0	GO:0004311	farnesyltranstransferase activity(GO:0004311)
0.0	0.0	GO:0004946	bombesin receptor activity(GO:0004946)
0.0	0.1	GO:0005522	profilin binding(GO:0005522)
0.0	0.2	GO:0051018	protein kinase A binding(GO:0051018)
0.0	0.3	GO:0019198	transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0	0.4	GO:0003950	NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0	0.1	GO:0017110	nucleoside-diphosphatase activity(GO:0017110)
0.0	0.1	GO:0004528	phosphodiesterase I activity(GO:0004528)
0.0	0.1	GO:0017091	AU-rich element binding(GO:0017091)
0.0	0.1	GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.0	0.0	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0	0.0	GO:0042608	T cell receptor binding(GO:0042608)
0.0	0.2	GO:0004697	protein kinase C activity(GO:0004697)
0.0	0.0	GO:0004924	oncostatin-M receptor activity(GO:0004924)
0.0	0.5	GO:0017048	Rho GTPase binding(GO:0017048)
0.0	0.0	GO:0000064	L-ornithine transmembrane transporter activity(GO:0000064)
0.0	0.1	GO:0015095	magnesium ion transmembrane transporter activity(GO:0015095)
0.0	0.0	GO:0050265	RNA uridylyltransferase activity(GO:0050265)
0.0	0.0	GO:0000247	C-8 sterol isomerase activity(GO:0000247)
0.0	0.1	GO:0015925	galactosidase activity(GO:0015925)
0.0	0.0	GO:0016748	succinyltransferase activity(GO:0016748)
0.0	0.4	GO:0004435	phosphatidylinositol phospholipase C activity(GO:0004435)
0.0	0.1	GO:0036002	pre-mRNA binding(GO:0036002)
0.0	0.1	GO:0016778	diphosphotransferase activity(GO:0016778)
0.0	0.1	GO:0003688	DNA replication origin binding(GO:0003688)
0.0	0.1	GO:0005337	nucleoside transmembrane transporter activity(GO:0005337)
0.0	0.0	GO:0015057	thrombin receptor activity(GO:0015057)
0.0	0.1	GO:0035251	UDP-glucosyltransferase activity(GO:0035251)
0.0	0.0	GO:0070579	methylcytosine dioxygenase activity(GO:0070579)
0.0	0.0	GO:0008486	diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486)
0.0	0.1	GO:0030742	GTP-dependent protein binding(GO:0030742)
0.0	0.0	GO:0043024	ribosomal small subunit binding(GO:0043024)
0.0	0.0	GO:0016882	cyclo-ligase activity(GO:0016882)
0.0	0.0	GO:0035514	DNA demethylase activity(GO:0035514) DNA-N1-methyladenine dioxygenase activity(GO:0043734)
0.0	0.0	GO:0034713	type I transforming growth factor beta receptor binding(GO:0034713)
0.0	0.2	GO:0030159	receptor signaling complex scaffold activity(GO:0030159)
0.0	0.0	GO:0030229	very-low-density lipoprotein particle receptor activity(GO:0030229)
0.0	0.0	GO:0015467	G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0	0.1	GO:0008296	3'-5'-exodeoxyribonuclease activity(GO:0008296)
0.0	0.1	GO:0004602	glutathione peroxidase activity(GO:0004602)
0.0	0.0	GO:0005030	neurotrophin receptor activity(GO:0005030)
0.0	0.0	GO:0070410	co-SMAD binding(GO:0070410)
0.0	0.1	GO:0030020	extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.0	0.0	GO:0052743	inositol tetrakisphosphate phosphatase activity(GO:0052743)
0.0	0.0	GO:0015252	hydrogen ion channel activity(GO:0015252)
0.0	0.2	GO:0005540	hyaluronic acid binding(GO:0005540)
0.0	0.1	GO:0048531	beta-1,3-galactosyltransferase activity(GO:0048531)
0.0	0.1	GO:0017176	phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0	0.0	GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.0	0.0	GO:0000739	obsolete DNA strand annealing activity(GO:0000739)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.0	PID IL5 PATHWAY	IL5-mediated signaling events
0.1	PID EPHA2 FWD PATHWAY	EPHA2 forward signaling
0.2	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.8	PID REELIN PATHWAY	Reelin signaling pathway
1.0	ST T CELL SIGNAL TRANSDUCTION	T Cell Signal Transduction
0.6	PID CDC42 REG PATHWAY	Regulation of CDC42 activity
0.2	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
0.2	ST TYPE I INTERFERON PATHWAY	Type I Interferon (alpha/beta IFN) Pathway
0.3	PID IL27 PATHWAY	IL27-mediated signaling events
0.8	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.3	PID ERB GENOMIC PATHWAY	Validated nuclear estrogen receptor beta network
0.0	ST GA13 PATHWAY	G alpha 13 Pathway
0.0	ST TUMOR NECROSIS FACTOR PATHWAY	Tumor Necrosis Factor Pathway.
0.0	PID AR NONGENOMIC PATHWAY	Nongenotropic Androgen signaling
0.2	PID THROMBIN PAR4 PATHWAY	PAR4-mediated thrombin signaling events
0.3	PID S1P S1P3 PATHWAY	S1P3 pathway
0.1	PID VEGFR1 PATHWAY	VEGFR1 specific signals
0.0	PID TCPTP PATHWAY	Signaling events mediated by TCPTP
0.0	SIG PIP3 SIGNALING IN B LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes
0.2	PID PI3K PLC TRK PATHWAY	Trk receptor signaling mediated by PI3K and PLC-gamma
0.1	PID TXA2PATHWAY	Thromboxane A2 receptor signaling
0.2	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1	PID NFKAPPAB CANONICAL PATHWAY	Canonical NF-kappaB pathway
0.1	PID ECADHERIN KERATINOCYTE PATHWAY	E-cadherin signaling in keratinocytes
0.2	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.0	0.0	REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE	Genes involved in Translocation of ZAP-70 to Immunological synapse
0.0	0.4	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0	0.4	REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION	Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0	0.4	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
0.0	0.2	REACTOME CD28 DEPENDENT VAV1 PATHWAY	Genes involved in CD28 dependent Vav1 pathway
0.0	0.1	REACTOME SEMA3A PAK DEPENDENT AXON REPULSION	Genes involved in Sema3A PAK dependent Axon repulsion
0.0	0.3	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.0	0.3	REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS	Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0	0.0	REACTOME SPRY REGULATION OF FGF SIGNALING	Genes involved in Spry regulation of FGF signaling
0.0	0.2	REACTOME IL 6 SIGNALING	Genes involved in Interleukin-6 signaling
0.0	0.0	REACTOME RNA POL I PROMOTER OPENING	Genes involved in RNA Polymerase I Promoter Opening
0.0	0.1	REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA	Genes involved in G beta:gamma signalling through PLC beta
0.0	0.0	REACTOME GPVI MEDIATED ACTIVATION CASCADE	Genes involved in GPVI-mediated activation cascade
0.0	0.1	REACTOME ACTIVATION OF RAC	Genes involved in Activation of Rac
0.0	0.2	REACTOME N GLYCAN ANTENNAE ELONGATION	Genes involved in N-Glycan antennae elongation
0.0	0.2	REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS	Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0	0.2	REACTOME UNWINDING OF DNA	Genes involved in Unwinding of DNA
0.0	0.1	REACTOME G PROTEIN BETA GAMMA SIGNALLING	Genes involved in G-protein beta:gamma signalling
0.0	0.1	REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS	Genes involved in Membrane binding and targetting of GAG proteins
0.0	0.9	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0	0.2	REACTOME ARMS MEDIATED ACTIVATION	Genes involved in ARMS-mediated activation
0.0	0.3	REACTOME EFFECTS OF PIP2 HYDROLYSIS	Genes involved in Effects of PIP2 hydrolysis
0.0	0.0	REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS	Genes involved in Elevation of cytosolic Ca2+ levels
0.0	0.3	REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE	Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.0	0.0	REACTOME REGULATED PROTEOLYSIS OF P75NTR	Genes involved in Regulated proteolysis of p75NTR
0.0	0.1	REACTOME NRIF SIGNALS CELL DEATH FROM THE NUCLEUS	Genes involved in NRIF signals cell death from the nucleus
0.0	0.4	REACTOME COSTIMULATION BY THE CD28 FAMILY	Genes involved in Costimulation by the CD28 family
0.0	0.1	REACTOME DAG AND IP3 SIGNALING	Genes involved in DAG and IP3 signaling
0.0	0.1	REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX	Genes involved in Association of licensing factors with the pre-replicative complex
0.0	0.2	REACTOME CHONDROITIN SULFATE BIOSYNTHESIS	Genes involved in Chondroitin sulfate biosynthesis
0.0	0.1	REACTOME CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE	Genes involved in Cell death signalling via NRAGE, NRIF and NADE
0.0	0.3	REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA	Genes involved in Circadian Repression of Expression by REV-ERBA
0.0	0.2	REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0	0.2	REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING	Genes involved in Downregulation of TGF-beta receptor signaling
0.0	0.0	REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1	Genes involved in Autodegradation of the E3 ubiquitin ligase COP1
0.0	0.1	REACTOME HYALURONAN UPTAKE AND DEGRADATION	Genes involved in Hyaluronan uptake and degradation
0.0	0.2	REACTOME IL RECEPTOR SHC SIGNALING	Genes involved in Interleukin receptor SHC signaling
0.0	0.0	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling