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ENCODE: H3K4me1 ChIP-Seq of primary human cells
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Results for ONECUT1

Z-value: 1.29

Motif logo

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Transcription factors associated with ONECUT1

Gene Symbol Gene ID Gene Info
ONECUT1
ENSG00000169856.7 one cut homeobox 1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr15_53081990_53082166ONECUT11310.977500-0.684.3e-02Click!
chr15_53075384_53075631ONECUT121270.4255050.617.9e-02Click!
chr15_53081158_53081309ONECUT19760.680244-0.581.0e-01Click!
chr15_53075819_53076008ONECUT125330.3876900.571.1e-01Click!
chr15_53494946_53495097ONECUT14128120.006931-0.551.2e-01Click!

Activity of the ONECUT1 motif across conditions

Conditions sorted by the z-value of the ONECUT1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr3_71754237_71754523 0.44 EIF4E3
 eukaryotic translation initiation factor 4E family member 3
 20146
 0.21
chr6_46934061_46934212 0.38 GPR116
 G protein-coupled receptor 116
 11456
 0.23
chr11_128356295_128356446 0.38 ETS1
 v-ets avian erythroblastosis virus E26 oncogene homolog 1
 18919
 0.24
chr18_67621349_67621587 0.36 CD226
 CD226 molecule
 2438
 0.41
chr1_172350739_172351257 0.36 DNM3
 dynamin 3
 2840
 0.24
chr2_69703322_69703473 0.36 NFU1
 NFU1 iron-sulfur cluster scaffold homolog (S. cerevisiae)
 38637
 0.14
chr2_204607032_204607284 0.35 ENSG00000211573
 .
 22363
 0.19
chr20_51025367_51025552 0.35 ZFP64
 ZFP64 zinc finger protein
 216934
 0.02
chr1_206752443_206752919 0.35 RASSF5
 Ras association (RalGDS/AF-6) domain family member 5
 22188
 0.14
chr15_91129425_91129576 0.34 CRTC3
 CREB regulated transcription coactivator 3
 7445
 0.17
chr7_114577295_114577446 0.34 MDFIC
 MyoD family inhibitor domain containing
 3446
 0.39
chr4_187853574_187853725 0.33 ENSG00000252382
 .
 75039
 0.13
chr15_33401071_33401222 0.33 FMN1
 formin 1
 40783
 0.2
chr11_117819899_117820198 0.32 TMPRSS13
 transmembrane protease, serine 13
 19874
 0.16
chrX_53693571_53693722 0.32 HUWE1
 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
 17468
 0.24
chr17_38779166_38779543 0.32 SMARCE1
 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
 9188
 0.15
chr15_60998831_60998982 0.32 RP11-219B17.2
25080
 0.18
chr1_67609394_67609545 0.31 C1orf141
 chromosome 1 open reading frame 141
 8809
 0.17
chrX_117670481_117670691 0.31 ENSG00000206862
 .
 32892
 0.18
chr14_75301018_75301169 0.31 RP11-316E14.6
9634
 0.14
chr3_11665619_11665770 0.31 VGLL4
 vestigial like 4 (Drosophila)
 3186
 0.26
chr12_110385989_110386149 0.31 TCHP
 trichoplein, keratin filament binding
 47655
 0.1
chr11_18652208_18652359 0.31 SPTY2D1
 SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae)
 3757
 0.19
chr15_25682392_25682786 0.31 UBE3A
 ubiquitin protein ligase E3A
 1099
 0.43
chr13_50667366_50667517 0.31 DLEU1
 deleted in lymphocytic leukemia 1 (non-protein coding)
 11134
 0.19
chr12_662501_663191 0.31 B4GALNT3
 beta-1,4-N-acetyl-galactosaminyl transferase 3
 10547
 0.16
chr1_169596848_169596999 0.30 SELP
 selectin P (granule membrane protein 140kDa, antigen CD62)
 2391
 0.32
chr1_24840661_24840812 0.30 RCAN3
 RCAN family member 3
 74
 0.97
chr2_225849112_225849337 0.30 ENSG00000263828
 .
 26033
 0.23
chr15_89171782_89171992 0.30 AEN
 apoptosis enhancing nuclease
 7286
 0.15
chr1_161034126_161034311 0.30 AL591806.1
 Uncharacterized protein
 1437
 0.2
chr2_143917081_143917249 0.29 RP11-190J23.1
12576
 0.25
chr15_38843563_38843770 0.29 RASGRP1
 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
 8617
 0.18
chr14_50447166_50447546 0.28 C14orf182
 chromosome 14 open reading frame 182
 26882
 0.15
chr14_32548210_32548608 0.28 ARHGAP5
 Rho GTPase activating protein 5
 972
 0.55
chr10_115607454_115607605 0.28 DCLRE1A
 DNA cross-link repair 1A
 6330
 0.18
chr15_33384160_33384311 0.28 FMN1
 formin 1
 23872
 0.25
chr2_85085633_85085887 0.28 TRABD2A
 TraB domain containing 2A
 22446
 0.18
chr17_65833184_65833335 0.28 ENSG00000265086
 .
 6802
 0.18
chr19_32839685_32839836 0.28 ZNF507
 zinc finger protein 507
 3135
 0.24
chr10_92962405_92962639 0.28 PCGF5
 polycomb group ring finger 5
 17386
 0.29
chr13_41011930_41012431 0.28 ENSG00000252812
 .
 30603
 0.23
chr2_205814595_205814746 0.28 PARD3B
 par-3 family cell polarity regulator beta
 403947
 0.01
chr9_4546909_4547086 0.28 SLC1A1
 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
 25338
 0.21
chr6_150020862_150021104 0.28 LATS1
 large tumor suppressor kinase 1
 2507
 0.23
chr15_26057779_26057955 0.27 ENSG00000199214
 .
 5263
 0.22
chr6_142866253_142866404 0.27 GPR126
 G protein-coupled receptor 126
 154879
 0.04
chr12_21605567_21605718 0.27 PYROXD1
 pyridine nucleotide-disulphide oxidoreductase domain 1
 14793
 0.17
chr1_24863399_24863781 0.27 ENSG00000266551
 .
 7386
 0.17
chr14_75334182_75334460 0.27 PROX2
 prospero homeobox 2
 3784
 0.17
chr4_27004622_27004939 0.27 STIM2
 stromal interaction molecule 2
 158
 0.98
chr13_96295415_96295566 0.27 DZIP1
 DAZ interacting zinc finger protein 1
 27
 0.98
chr2_181909294_181909445 0.27 UBE2E3
 ubiquitin-conjugating enzyme E2E 3
 62619
 0.14
chr11_114053249_114053976 0.27 NNMT
 nicotinamide N-methyltransferase
 74941
 0.09
chr10_86091819_86091970 0.27 CCSER2
 coiled-coil serine-rich protein 2
 3475
 0.31
chr17_76113070_76113221 0.27 ENSG00000204282
 .
 5265
 0.13
chr7_50364049_50364214 0.26 IKZF1
 IKAROS family zinc finger 1 (Ikaros)
 3114
 0.37
chr12_102188801_102188952 0.26 ENSG00000222932
 .
 1404
 0.27
chr2_179901450_179901601 0.26 CCDC141
 coiled-coil domain containing 141
 13261
 0.21
chr9_137193267_137193522 0.26 RXRA
 retinoid X receptor, alpha
 25032
 0.22
chr11_104668978_104669231 0.26 CASP12
 caspase 12 (gene/pseudogene)
 100037
 0.07
chr3_43518340_43518545 0.26 ENSG00000251811
 .
 4473
 0.29
chr1_112020337_112020708 0.26 C1orf162
 chromosome 1 open reading frame 162
 4031
 0.12
chr12_47788688_47788839 0.26 ENSG00000264906
 .
 30711
 0.19
chrX_135738263_135738414 0.26 CD40LG
 CD40 ligand
 7952
 0.18
chr1_12234665_12234953 0.26 TNFRSF1B
 tumor necrosis factor receptor superfamily, member 1B
 7749
 0.16
chr10_28507230_28507496 0.26 MPP7
 membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)
 20303
 0.25
chr8_125654530_125654866 0.26 RP11-532M24.1
62826
 0.11
chr2_182381274_182381425 0.26 ITGA4
 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
 59194
 0.14
chr2_136886605_136886811 0.26 CXCR4
 chemokine (C-X-C motif) receptor 4
 10973
 0.28
chr4_109036061_109036413 0.26 LEF1
 lymphoid enhancer-binding factor 1
 51220
 0.14
chr11_108120449_108120621 0.26 AP001925.1
15945
 0.15
chr2_198896763_198896914 0.26 PLCL1
 phospholipase C-like 1
 51698
 0.18
chr8_66701143_66701322 0.26 PDE7A
 phosphodiesterase 7A
 87
 0.98
chr2_202113259_202113410 0.26 CASP8
 caspase 8, apoptosis-related cysteine peptidase
 9369
 0.19
chr20_8125317_8125709 0.26 PLCB1
 phospholipase C, beta 1 (phosphoinositide-specific)
 12211
 0.27
chr3_71142898_71143049 0.26 FOXP1
 forkhead box P1
 28055
 0.26
chr1_84630834_84631034 0.26 PRKACB
 protein kinase, cAMP-dependent, catalytic, beta
 285
 0.94
chr10_104513769_104513920 0.25 WBP1L
 WW domain binding protein 1-like
 10117
 0.15
chr12_92692622_92693037 0.25 RP11-693J15.4
122478
 0.05
chr19_49164522_49164784 0.25 NTN5
 netrin 5
 11611
 0.08
chr8_20351774_20351998 0.25 ENSG00000251944
 .
 120551
 0.06
chr1_116933196_116933468 0.25 AL136376.1
 Uncharacterized protein
 6614
 0.16
chr2_46978789_46978940 0.25 SOCS5
 suppressor of cytokine signaling 5
 52538
 0.11
chr1_147101695_147101978 0.25 ACP6
 acid phosphatase 6, lysophosphatidic
 29280
 0.19
chr6_135356178_135356329 0.25 HBS1L
 HBS1-like (S. cerevisiae)
 7919
 0.22
chr8_2080105_2080333 0.25 MYOM2
 myomesin 2
 87035
 0.1
chr12_109538291_109538505 0.25 UNG
 uracil-DNA glycosylase
 2475
 0.18
chr11_3401052_3401203 0.25 ZNF195
 zinc finger protein 195
 679
 0.64
chr6_167531770_167531921 0.25 CCR6
 chemokine (C-C motif) receptor 6
 4412
 0.22
chr14_106620952_106621103 0.25 IGHVII-15-1
 immunoglobulin heavy variable (II)-15-1 (pseudogene)
 538
 0.39
chr4_95365853_95366004 0.25 PDLIM5
 PDZ and LIM domain 5
 7109
 0.32
chr10_90585510_90585661 0.25 LIPM
 lipase, family member M
 22880
 0.15
chr17_28723594_28723745 0.25 CPD
 carboxypeptidase D
 16415
 0.15
chr12_56496025_56496345 0.25 RP11-603J24.9
 Uncharacterized protein
 1070
 0.22
chr3_58481037_58481337 0.25 KCTD6
 potassium channel tetramerization domain containing 6
 1545
 0.38
chr5_171387448_171387599 0.24 FBXW11
 F-box and WD repeat domain containing 11
 17237
 0.25
chr7_36084778_36084929 0.24 PP13004
33841
 0.18
chr6_40608172_40608323 0.24 LRFN2
 leucine rich repeat and fibronectin type III domain containing 2
 53043
 0.16
chr15_87159734_87160062 0.24 RP11-182L7.1
14469
 0.3
chr17_1336289_1336440 0.24 RP11-818O24.3
8294
 0.15
chr13_32347129_32347280 0.24 RXFP2
 relaxin/insulin-like family peptide receptor 2
 33525
 0.24
chr21_47788624_47788796 0.24 PCNT
 pericentrin
 44674
 0.1
chr8_141641731_141641895 0.24 AGO2
 argonaute RISC catalytic component 2
 3832
 0.28
chr8_119821666_119821817 0.24 TNFRSF11B
 tumor necrosis factor receptor superfamily, member 11b
 142698
 0.05
chr14_98657577_98657728 0.24 ENSG00000222066
 .
 140435
 0.05
chr2_201331001_201331184 0.24 SPATS2L
 spermatogenesis associated, serine-rich 2-like
 25720
 0.16
chr2_12874585_12874736 0.24 ENSG00000264370
 .
 2833
 0.34
chr7_158936629_158936995 0.24 VIPR2
 vasoactive intestinal peptide receptor 2
 732
 0.8
chr16_3623403_3623748 0.24 NLRC3
 NLR family, CARD domain containing 3
 3817
 0.17
chr15_64861726_64861912 0.24 ZNF609
 zinc finger protein 609
 70328
 0.07
chr6_159635157_159635308 0.24 FNDC1
 fibronectin type III domain containing 1
 16753
 0.2
chr7_6546712_6546863 0.24 KDELR2
 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
 22914
 0.11
chr5_138641580_138641731 0.24 MATR3
 matrin 3
 2129
 0.19
chr12_40023474_40023652 0.24 C12orf40
 chromosome 12 open reading frame 40
 3578
 0.29
chrX_149880583_149880734 0.24 MTMR1
 myotubularin related protein 1
 6491
 0.3
chr6_510010_510533 0.24 RP1-20B11.2
13900
 0.28
chr10_76346905_76347116 0.23 ENSG00000206756
 .
 35860
 0.2
chr10_22028920_22029395 0.23 ENSG00000252634
 .
 45064
 0.15
chr11_88579489_88579640 0.23 GRM5
 glutamate receptor, metabotropic 5
 200974
 0.03
chr16_56226659_56226810 0.23 GNAO1
 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
 329
 0.86
chr1_36611019_36611170 0.23 TRAPPC3
 trafficking protein particle complex 3
 3958
 0.17
chr9_131337014_131337165 0.23 SPTAN1
 spectrin, alpha, non-erythrocytic 1
 22220
 0.11
chr8_61449115_61449422 0.23 RP11-91I20.4
16327
 0.21
chr8_81927272_81927636 0.23 PAG1
 phosphoprotein associated with glycosphingolipid microdomains 1
 96849
 0.08
chrX_48792186_48792645 0.23 PIM2
 pim-2 oncogene
 16114
 0.08
chr14_21723112_21723263 0.23 HNRNPC
 heterogeneous nuclear ribonucleoprotein C (C1/C2)
 7649
 0.18
chr3_18442605_18442786 0.23 RP11-158G18.1
8432
 0.23
chr2_161185571_161185758 0.23 ENSG00000252465
 .
 67815
 0.11
chr5_133462716_133463173 0.23 TCF7
 transcription factor 7 (T-cell specific, HMG-box)
 3635
 0.26
chr1_198529109_198529554 0.23 ATP6V1G3
 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3
 19256
 0.26
chr12_92405753_92405904 0.23 C12orf79
 chromosome 12 open reading frame 79
 124969
 0.05
chr11_4027933_4028182 0.23 STIM1
 stromal interaction molecule 1
 51922
 0.12
chr20_37626778_37626929 0.23 DHX35
 DEAH (Asp-Glu-Ala-His) box polypeptide 35
 23663
 0.19
chr10_33375837_33376051 0.23 ENSG00000263576
 .
 11620
 0.23
chr2_46665689_46665843 0.23 ENSG00000241791
 .
 9884
 0.2
chr14_75580842_75580993 0.23 NEK9
 NIMA-related kinase 9
 12826
 0.13
chr2_240541514_240541718 0.23 AC079612.1
 Uncharacterized protein; cDNA FLJ45964 fis, clone PLACE7014396
 41621
 0.19
chr15_61012596_61012899 0.23 ENSG00000212625
 .
 16221
 0.2
chrX_41779550_41779701 0.23 ENSG00000251807
 .
 1023
 0.57
chr14_22410532_22410683 0.23 ENSG00000222776
 .
 161822
 0.03
chr9_4600854_4601005 0.23 SLC1A1
 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
 28594
 0.17
chr2_203533655_203533879 0.23 FAM117B
 family with sequence similarity 117, member B
 33856
 0.22
chr13_109061568_109062120 0.23 ENSG00000223177
 .
 108165
 0.07
chr1_101748824_101749089 0.23 RP4-575N6.5
40242
 0.14
chr1_78138076_78138256 0.23 ZZZ3
 zinc finger, ZZ-type containing 3
 10177
 0.18
chr5_76029378_76029529 0.23 CTD-2384B11.2
17413
 0.16
chr9_120309696_120309847 0.23 ASTN2
 astrotactin 2
 132423
 0.05
chr11_98448599_98448750 0.23 CNTN5
 contactin 5
 443197
 0.01
chr5_76940805_76940962 0.23 OTP
 orthopedia homeobox
 5370
 0.26
chr13_51466339_51466600 0.23 RNASEH2B-AS1
 RNASEH2B antisense RNA 1
 691
 0.7
chr5_78809205_78809433 0.23 HOMER1
 homer homolog 1 (Drosophila)
 702
 0.74
chr22_42259302_42259453 0.22 RP5-821D11.7
28708
 0.09
chr10_127934738_127934889 0.22 ENSG00000222740
 .
 100662
 0.08
chr10_28855331_28855500 0.22 WAC
 WW domain containing adaptor with coiled-coil
 32363
 0.16
chr6_128136934_128137193 0.22 THEMIS
 thymocyte selection associated
 85040
 0.1
chr12_68176752_68176973 0.22 RP11-335O4.3
112163
 0.07
chr10_121403059_121403303 0.22 BAG3
 BCL2-associated athanogene 3
 7701
 0.23
chr5_32585003_32585380 0.22 SUB1
 SUB1 homolog (S. cerevisiae)
 414
 0.9
chr16_67058607_67058758 0.22 CBFB
 core-binding factor, beta subunit
 4337
 0.14
chr22_33138990_33139141 0.22 LL22NC01-116C6.1
40098
 0.17
chr17_4078920_4079071 0.22 ENSG00000251812
 .
 10626
 0.11
chr6_135888948_135889171 0.22 AHI1
 Abelson helper integration site 1
 70145
 0.12
chr20_57233689_57233840 0.22 STX16
 syntaxin 16
 6701
 0.17
chr11_128567905_128568246 0.22 SENCR
 smooth muscle and endothelial cell enriched migration/differentiation-associated long non-coding RNA
 2157
 0.29
chr5_110567747_110567898 0.22 CAMK4
 calcium/calmodulin-dependent protein kinase IV
 8038
 0.23
chr6_131534478_131534629 0.22 AKAP7
 A kinase (PRKA) anchor protein 7
 12586
 0.3
chr7_127054523_127055019 0.22 ZNF800
 zinc finger protein 800
 17207
 0.24
chr6_41020375_41020526 0.22 APOBEC2
 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2
 593
 0.64
chr13_74629447_74629598 0.22 KLF12
 Kruppel-like factor 12
 60336
 0.16
chr12_11856534_11856685 0.22 ETV6
 ets variant 6
 48826
 0.17
chr3_101248750_101248908 0.22 SENP7
 SUMO1/sentrin specific peptidase 7
 16744
 0.14
chr2_234898182_234898466 0.22 TRPM8
 transient receptor potential cation channel, subfamily M, member 8
 23062
 0.19
chr2_158318490_158318649 0.22 CYTIP
 cytohesin 1 interacting protein
 17915
 0.21
chr5_146173697_146173862 0.22 ENSG00000265875
 .
 59381
 0.13
chr17_57904009_57904390 0.22 ENSG00000199004
 .
 14428
 0.14
chr1_241798904_241799055 0.22 CHML
 choroideremia-like (Rab escort protein 2)
 253
 0.92
chr11_33301093_33301244 0.22 HIPK3
 homeodomain interacting protein kinase 3
 21291
 0.2
chr14_50453111_50453411 0.22 C14orf182
 chromosome 14 open reading frame 182
 20977
 0.16
chr2_135037343_135037494 0.22 MGAT5
 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase
 25588
 0.23
chr4_54926277_54926428 0.22 AC110792.1
 HCG2027126; Uncharacterized protein
 861
 0.57
chr2_204863439_204863670 0.22 ICOS
 inducible T-cell co-stimulator
 62051
 0.15
chr14_52312481_52312871 0.22 GNG2
 guanine nucleotide binding protein (G protein), gamma 2
 1168
 0.53
chr14_97926659_97926899 0.22 ENSG00000240730
 .
 69731
 0.14
chr10_101419948_101420125 0.22 ENTPD7
 ectonucleoside triphosphate diphosphohydrolase 7
 773
 0.57
chr12_117361072_117361223 0.22 FBXW8
 F-box and WD repeat domain containing 8
 12377
 0.22
chr1_230308225_230308481 0.22 RP5-956O18.2
95876
 0.07
chr3_18445696_18446011 0.22 RP11-158G18.1
5274
 0.25
chr7_15498785_15499062 0.22 AGMO
 alkylglycerol monooxygenase
 93076
 0.1
chr19_53178787_53178938 0.21 ZNF83
 zinc finger protein 83
 14765
 0.14
chr11_114018411_114018569 0.21 ENSG00000221112
 .
 60839
 0.12
chr10_93690175_93690326 0.21 BTAF1
 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa
 6724
 0.2
chr1_167612000_167612291 0.21 RP3-455J7.4
12234
 0.19
chr10_1979822_1979973 0.21 ENSG00000252998
 .
 160464
 0.04
chr6_26442991_26443142 0.21 BTN3A3
 butyrophilin, subfamily 3, member A3
 2280
 0.18
chr1_42793424_42793575 0.21 FOXJ3
 forkhead box J3
 7137
 0.2
chr8_100559197_100559348 0.21 ENSG00000216069
 .
 10183
 0.16
chr1_200840277_200840712 0.21 GPR25
 G protein-coupled receptor 25
 1589
 0.37
chr7_36830344_36830495 0.21 AC007349.7
48158
 0.15
chr10_70377879_70378030 0.21 TET1
 tet methylcytosine dioxygenase 1
 57541
 0.09

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of ONECUT1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:1901339 activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.1 0.4 GO:0033152 immunoglobulin V(D)J recombination(GO:0033152)
0.1 0.2 GO:0030223 neutrophil differentiation(GO:0030223)
0.1 0.6 GO:0006198 cAMP catabolic process(GO:0006198)
0.1 0.1 GO:0045074 interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.1 0.5 GO:0002837 regulation of response to tumor cell(GO:0002834) positive regulation of response to tumor cell(GO:0002836) regulation of immune response to tumor cell(GO:0002837) positive regulation of immune response to tumor cell(GO:0002839)
0.1 0.2 GO:0002313 mature B cell differentiation involved in immune response(GO:0002313)
0.1 0.2 GO:0009138 pyrimidine nucleoside diphosphate metabolic process(GO:0009138)
0.1 0.3 GO:0050857 positive regulation of antigen receptor-mediated signaling pathway(GO:0050857)
0.1 0.2 GO:0046642 negative regulation of alpha-beta T cell proliferation(GO:0046642)
0.1 0.2 GO:0010867 positive regulation of triglyceride biosynthetic process(GO:0010867)
0.1 0.2 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.1 0.2 GO:0019276 UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.1 0.2 GO:0032236 obsolete positive regulation of calcium ion transport via store-operated calcium channel activity(GO:0032236)
0.1 0.2 GO:0010508 positive regulation of autophagy(GO:0010508)
0.0 0.1 GO:0060413 atrial septum development(GO:0003283) atrial septum morphogenesis(GO:0060413)
0.0 0.1 GO:0051834 evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.0 0.0 GO:0002513 tolerance induction to self antigen(GO:0002513)
0.0 0.0 GO:0051152 positive regulation of smooth muscle cell differentiation(GO:0051152)
0.0 0.1 GO:0048388 endosomal lumen acidification(GO:0048388)
0.0 0.0 GO:0021754 facial nucleus development(GO:0021754)
0.0 0.3 GO:0045066 regulatory T cell differentiation(GO:0045066)
0.0 0.0 GO:0002677 negative regulation of chronic inflammatory response(GO:0002677)
0.0 0.1 GO:0031223 auditory behavior(GO:0031223)
0.0 0.1 GO:0010957 negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137)
0.0 0.1 GO:0034135 regulation of toll-like receptor 2 signaling pathway(GO:0034135)
0.0 0.2 GO:0030910 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.0 0.3 GO:0008653 lipopolysaccharide metabolic process(GO:0008653)
0.0 0.0 GO:0009189 deoxyribonucleoside diphosphate biosynthetic process(GO:0009189)
0.0 0.2 GO:0042989 sequestering of actin monomers(GO:0042989)
0.0 0.1 GO:0002248 connective tissue replacement involved in inflammatory response wound healing(GO:0002248) connective tissue replacement(GO:0097709)
0.0 0.3 GO:0032733 positive regulation of interleukin-10 production(GO:0032733)
0.0 0.2 GO:0032876 regulation of DNA endoreduplication(GO:0032875) negative regulation of DNA endoreduplication(GO:0032876) DNA endoreduplication(GO:0042023)
0.0 0.1 GO:0010572 positive regulation of platelet activation(GO:0010572)
0.0 0.4 GO:0043368 positive T cell selection(GO:0043368)
0.0 0.1 GO:0045722 positive regulation of gluconeogenesis(GO:0045722)
0.0 0.2 GO:0060023 soft palate development(GO:0060023)
0.0 0.1 GO:0016266 O-glycan processing(GO:0016266)
0.0 0.1 GO:0015864 pyrimidine nucleoside transport(GO:0015864)
0.0 0.2 GO:0016556 mRNA modification(GO:0016556)
0.0 0.0 GO:1904063 negative regulation of ion transmembrane transporter activity(GO:0032413) negative regulation of cation transmembrane transport(GO:1904063)
0.0 0.2 GO:0006346 methylation-dependent chromatin silencing(GO:0006346)
0.0 0.1 GO:0042661 regulation of mesodermal cell fate specification(GO:0042661) regulation of mesoderm development(GO:2000380)
0.0 0.2 GO:0031498 nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.0 0.1 GO:1901797 negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518) negative regulation of signal transduction by p53 class mediator(GO:1901797)
0.0 0.2 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 0.2 GO:0051926 negative regulation of calcium ion transport(GO:0051926)
0.0 0.2 GO:0002063 chondrocyte development(GO:0002063)
0.0 0.1 GO:0060049 regulation of protein glycosylation(GO:0060049)
0.0 0.1 GO:0010587 miRNA metabolic process(GO:0010586) miRNA catabolic process(GO:0010587)
0.0 0.1 GO:0070634 transepithelial ammonium transport(GO:0070634)
0.0 0.1 GO:0014834 skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration(GO:0014834)
0.0 0.1 GO:0007343 egg activation(GO:0007343)
0.0 0.1 GO:0036072 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.0 0.2 GO:0097354 protein prenylation(GO:0018342) prenylation(GO:0097354)
0.0 0.1 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0 0.1 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.0 0.1 GO:0022614 membrane to membrane docking(GO:0022614)
0.0 0.2 GO:0045648 positive regulation of erythrocyte differentiation(GO:0045648)
0.0 0.1 GO:0015959 diadenosine polyphosphate metabolic process(GO:0015959)
0.0 0.0 GO:0010040 response to iron(II) ion(GO:0010040)
0.0 0.1 GO:0006552 leucine catabolic process(GO:0006552)
0.0 0.1 GO:0001672 regulation of chromatin assembly or disassembly(GO:0001672)
0.0 0.1 GO:0032410 negative regulation of transporter activity(GO:0032410)
0.0 0.1 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0 0.0 GO:0044803 multi-organism membrane organization(GO:0044803)
0.0 0.1 GO:0007352 zygotic specification of dorsal/ventral axis(GO:0007352)
0.0 0.1 GO:0080111 DNA demethylation(GO:0080111)
0.0 0.1 GO:0048024 regulation of mRNA splicing, via spliceosome(GO:0048024)
0.0 0.1 GO:0007406 negative regulation of neuroblast proliferation(GO:0007406) negative regulation of neural precursor cell proliferation(GO:2000178)
0.0 0.0 GO:0009786 regulation of asymmetric cell division(GO:0009786)
0.0 0.1 GO:0060528 secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.0 0.1 GO:0006772 thiamine metabolic process(GO:0006772)
0.0 0.1 GO:0043653 mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.0 0.0 GO:0060596 mammary placode formation(GO:0060596)
0.0 0.0 GO:0030011 maintenance of cell polarity(GO:0030011)
0.0 0.1 GO:0006498 N-terminal protein lipidation(GO:0006498)
0.0 0.0 GO:0045654 positive regulation of megakaryocyte differentiation(GO:0045654) positive regulation of hematopoietic progenitor cell differentiation(GO:1901534)
0.0 0.1 GO:0045948 positive regulation of translational initiation(GO:0045948)
0.0 0.1 GO:0006975 DNA damage induced protein phosphorylation(GO:0006975)
0.0 0.1 GO:0032525 somite rostral/caudal axis specification(GO:0032525)
0.0 0.0 GO:0048670 regulation of collateral sprouting(GO:0048670)
0.0 0.1 GO:0045601 regulation of endothelial cell differentiation(GO:0045601)
0.0 0.1 GO:0007256 activation of JNKK activity(GO:0007256)
0.0 0.0 GO:0002874 regulation of chronic inflammatory response to antigenic stimulus(GO:0002874)
0.0 0.2 GO:0048843 negative regulation of axon extension involved in axon guidance(GO:0048843)
0.0 0.1 GO:0060123 regulation of growth hormone secretion(GO:0060123)
0.0 0.2 GO:0033631 cell-cell adhesion mediated by integrin(GO:0033631)
0.0 0.1 GO:0007008 outer mitochondrial membrane organization(GO:0007008) protein import into mitochondrial outer membrane(GO:0045040)
0.0 0.1 GO:0060662 tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662)
0.0 0.0 GO:0048304 positive regulation of isotype switching to IgG isotypes(GO:0048304)
0.0 0.1 GO:0035583 sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.0 0.2 GO:0051828 entry into host cell(GO:0030260) entry into host(GO:0044409) entry into cell of other organism involved in symbiotic interaction(GO:0051806) entry into other organism involved in symbiotic interaction(GO:0051828)
0.0 0.0 GO:0006927 obsolete transformed cell apoptotic process(GO:0006927)
0.0 0.1 GO:0032790 ribosome disassembly(GO:0032790)
0.0 0.1 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.0 0.0 GO:0032776 DNA methylation on cytosine(GO:0032776) C-5 methylation of cytosine(GO:0090116)
0.0 0.1 GO:0048535 lymph node development(GO:0048535)
0.0 0.0 GO:0002634 regulation of germinal center formation(GO:0002634)
0.0 0.1 GO:0008356 asymmetric cell division(GO:0008356)
0.0 0.1 GO:0021913 regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913)
0.0 0.1 GO:0006089 lactate metabolic process(GO:0006089)
0.0 0.2 GO:0070536 protein K63-linked deubiquitination(GO:0070536)
0.0 0.1 GO:0006104 succinyl-CoA metabolic process(GO:0006104)
0.0 0.1 GO:0006538 glutamate catabolic process(GO:0006538)
0.0 0.1 GO:0006032 chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.0 0.1 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
0.0 0.0 GO:0051461 corticotropin secretion(GO:0051458) regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461)
0.0 0.1 GO:0060391 positive regulation of SMAD protein import into nucleus(GO:0060391)
0.0 0.2 GO:0016578 histone deubiquitination(GO:0016578)
0.0 0.0 GO:0071502 cellular response to temperature stimulus(GO:0071502)
0.0 0.0 GO:0043578 nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0 0.1 GO:0006422 aspartyl-tRNA aminoacylation(GO:0006422)
0.0 0.2 GO:0034199 activation of protein kinase A activity(GO:0034199)
0.0 0.0 GO:0010815 bradykinin catabolic process(GO:0010815)
0.0 0.0 GO:0043117 positive regulation of vascular permeability(GO:0043117)
0.0 0.0 GO:0051533 positive regulation of NFAT protein import into nucleus(GO:0051533)
0.0 0.0 GO:0050955 thermoception(GO:0050955)
0.0 0.1 GO:0045078 positive regulation of interferon-gamma biosynthetic process(GO:0045078)
0.0 0.1 GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770)
0.0 0.3 GO:0030838 positive regulation of actin filament polymerization(GO:0030838)
0.0 0.0 GO:0046100 hypoxanthine metabolic process(GO:0046100)
0.0 0.0 GO:0072179 nephric duct formation(GO:0072179)
0.0 0.1 GO:0060678 dichotomous subdivision of terminal units involved in ureteric bud branching(GO:0060678)
0.0 0.0 GO:0002523 leukocyte migration involved in inflammatory response(GO:0002523)
0.0 0.1 GO:0033962 cytoplasmic mRNA processing body assembly(GO:0033962)
0.0 0.0 GO:0030259 lipid glycosylation(GO:0030259)
0.0 0.0 GO:0000733 DNA strand renaturation(GO:0000733)
0.0 0.0 GO:0048263 determination of dorsal identity(GO:0048263)
0.0 0.1 GO:0021535 cell migration in hindbrain(GO:0021535)
0.0 0.0 GO:0001996 positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996)
0.0 0.3 GO:0050690 regulation of defense response to virus by virus(GO:0050690)
0.0 0.0 GO:0031935 regulation of chromatin silencing(GO:0031935) negative regulation of chromatin silencing(GO:0031936)
0.0 0.0 GO:0090286 cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.0 0.0 GO:0070682 proteasome regulatory particle assembly(GO:0070682)
0.0 0.1 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.0 0.0 GO:0006922 obsolete cleavage of lamin involved in execution phase of apoptosis(GO:0006922)
0.0 0.0 GO:0010792 DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792) double-strand break repair via single-strand annealing(GO:0045002)
0.0 0.1 GO:0006688 glycosphingolipid biosynthetic process(GO:0006688)
0.0 0.0 GO:0021978 telencephalon regionalization(GO:0021978)
0.0 0.1 GO:0009312 oligosaccharide biosynthetic process(GO:0009312)
0.0 0.0 GO:0035455 response to interferon-alpha(GO:0035455)
0.0 0.0 GO:0042996 regulation of Golgi to plasma membrane protein transport(GO:0042996)
0.0 0.0 GO:0015705 iodide transport(GO:0015705)
0.0 0.0 GO:0017182 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.0 0.1 GO:0021854 hypothalamus development(GO:0021854)
0.0 0.0 GO:0042510 regulation of tyrosine phosphorylation of Stat1 protein(GO:0042510) positive regulation of tyrosine phosphorylation of Stat1 protein(GO:0042511)
0.0 0.0 GO:0030505 inorganic diphosphate transport(GO:0030505)
0.0 0.0 GO:0070933 histone H3 deacetylation(GO:0070932) histone H4 deacetylation(GO:0070933)
0.0 0.0 GO:0019255 glucose 1-phosphate metabolic process(GO:0019255)
0.0 0.0 GO:0032914 positive regulation of transforming growth factor beta1 production(GO:0032914)
0.0 0.0 GO:0048630 skeletal muscle tissue growth(GO:0048630)
0.0 0.0 GO:0009048 dosage compensation by inactivation of X chromosome(GO:0009048)
0.0 0.0 GO:0002507 tolerance induction(GO:0002507)
0.0 0.0 GO:0051305 chromosome movement towards spindle pole(GO:0051305)
0.0 0.0 GO:0022038 corpus callosum development(GO:0022038)
0.0 0.1 GO:0018027 peptidyl-lysine dimethylation(GO:0018027)
0.0 0.1 GO:0019885 antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.0 0.0 GO:0007207 phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.0 0.0 GO:0045875 negative regulation of sister chromatid cohesion(GO:0045875)
0.0 0.1 GO:0006477 protein sulfation(GO:0006477)
0.0 0.0 GO:0051182 coenzyme transport(GO:0051182)
0.0 0.0 GO:0021894 interneuron migration from the subpallium to the cortex(GO:0021830) cerebral cortex GABAergic interneuron migration(GO:0021853) cerebral cortex GABAergic interneuron development(GO:0021894) interneuron migration(GO:1904936)
0.0 0.0 GO:0021571 rhombomere 5 development(GO:0021571)
0.0 0.0 GO:0006642 triglyceride mobilization(GO:0006642)
0.0 0.0 GO:0000729 DNA double-strand break processing(GO:0000729)
0.0 0.0 GO:0072600 protein targeting to Golgi(GO:0000042) establishment of protein localization to Golgi(GO:0072600)
0.0 0.1 GO:0060039 pericardium development(GO:0060039)
0.0 0.0 GO:0002691 regulation of cellular extravasation(GO:0002691)
0.0 0.0 GO:0010989 negative regulation of low-density lipoprotein particle clearance(GO:0010989)
0.0 0.1 GO:0043268 positive regulation of potassium ion transport(GO:0043268)
0.0 0.0 GO:0032543 mitochondrial translation(GO:0032543)
0.0 0.0 GO:0033147 negative regulation of intracellular estrogen receptor signaling pathway(GO:0033147)
0.0 0.1 GO:0006734 NADH metabolic process(GO:0006734)
0.0 0.1 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
0.0 0.1 GO:0051775 response to redox state(GO:0051775)
0.0 0.0 GO:0032455 nerve growth factor processing(GO:0032455)
0.0 0.1 GO:0045003 DNA recombinase assembly(GO:0000730) double-strand break repair via synthesis-dependent strand annealing(GO:0045003)
0.0 0.1 GO:0042987 amyloid precursor protein catabolic process(GO:0042987)
0.0 0.2 GO:0042462 eye photoreceptor cell development(GO:0042462)
0.0 0.1 GO:0044091 membrane biogenesis(GO:0044091)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0 0.2 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.0 0.1 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.0 0.4 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.0 0.1 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.0 0.1 GO:0031932 TORC2 complex(GO:0031932)
0.0 0.1 GO:0032444 activin responsive factor complex(GO:0032444)
0.0 0.2 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.0 0.3 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 0.2 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.1 GO:0000153 cytoplasmic ubiquitin ligase complex(GO:0000153)
0.0 0.1 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 0.0 GO:0033270 paranode region of axon(GO:0033270)
0.0 0.1 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 0.1 GO:0000137 Golgi cis cisterna(GO:0000137)
0.0 0.1 GO:0031464 Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.0 0.1 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 0.1 GO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
0.0 0.1 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.0 0.1 GO:0031264 death-inducing signaling complex(GO:0031264)
0.0 0.2 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.1 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0 0.1 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.1 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 0.0 GO:0031205 endoplasmic reticulum Sec complex(GO:0031205)
0.0 0.1 GO:0034992 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 0.1 GO:0034464 BBSome(GO:0034464)
0.0 0.0 GO:0070852 cell body fiber(GO:0070852)
0.0 0.1 GO:0005826 actomyosin contractile ring(GO:0005826)
0.0 0.1 GO:0016942 insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454)
0.0 0.1 GO:0043190 ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.0 0.1 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.0 0.1 GO:0034518 mRNA cap binding complex(GO:0005845) RNA cap binding complex(GO:0034518)
0.0 0.3 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.1 GO:0045120 pronucleus(GO:0045120)
0.0 0.0 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 0.0 GO:0005900 oncostatin-M receptor complex(GO:0005900)
0.0 0.1 GO:0031105 septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.0 0.0 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.0 0.0 GO:0005954 calcium- and calmodulin-dependent protein kinase complex(GO:0005954)
0.0 0.1 GO:0043034 costamere(GO:0043034)
0.0 0.0 GO:0030008 TRAPP complex(GO:0030008)
0.0 0.0 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.0 0.1 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.3 GO:0005626 obsolete insoluble fraction(GO:0005626)
0.0 0.3 GO:0032587 ruffle membrane(GO:0032587)
0.0 0.0 GO:0033185 mannosyltransferase complex(GO:0031501) dolichol-phosphate-mannose synthase complex(GO:0033185)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0031628 opioid receptor binding(GO:0031628)
0.1 0.2 GO:0003829 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0003829)
0.1 0.2 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.1 0.3 GO:0031013 troponin I binding(GO:0031013)
0.1 0.2 GO:0030284 estrogen receptor activity(GO:0030284)
0.0 0.1 GO:0042910 xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.0 0.2 GO:0035252 UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285)
0.0 0.1 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.0 0.3 GO:0016494 C-X-C chemokine receptor activity(GO:0016494)
0.0 0.1 GO:0004999 vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.0 0.3 GO:0008318 protein prenyltransferase activity(GO:0008318)
0.0 0.1 GO:0047756 chondroitin 4-sulfotransferase activity(GO:0047756)
0.0 0.3 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.1 GO:0004911 interleukin-2 receptor activity(GO:0004911)
0.0 0.2 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.0 0.3 GO:0030332 cyclin binding(GO:0030332)
0.0 0.5 GO:0005246 calcium channel regulator activity(GO:0005246)
0.0 0.1 GO:0003872 6-phosphofructokinase activity(GO:0003872)
0.0 0.1 GO:0047238 glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.0 0.2 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0 0.5 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.2 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.0 0.3 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity(GO:0034593)
0.0 0.2 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0 0.1 GO:0033691 sialic acid binding(GO:0033691)
0.0 0.3 GO:0016493 C-C chemokine receptor activity(GO:0016493)
0.0 0.1 GO:0004677 DNA-dependent protein kinase activity(GO:0004677)
0.0 0.1 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.1 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.0 0.1 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.0 0.1 GO:0019870 potassium channel inhibitor activity(GO:0019870)
0.0 0.1 GO:0030911 TPR domain binding(GO:0030911)
0.0 0.1 GO:0015379 potassium:chloride symporter activity(GO:0015379)
0.0 0.1 GO:0015377 cation:chloride symporter activity(GO:0015377)
0.0 0.1 GO:0035198 miRNA binding(GO:0035198)
0.0 0.5 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.1 GO:0043141 ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.0 0.3 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.0 0.0 GO:0004690 cyclic nucleotide-dependent protein kinase activity(GO:0004690)
0.0 0.1 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0 0.1 GO:0004126 cytidine deaminase activity(GO:0004126)
0.0 0.1 GO:0004803 transposase activity(GO:0004803)
0.0 0.2 GO:0004467 long-chain fatty acid-CoA ligase activity(GO:0004467)
0.0 0.2 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0 0.1 GO:0070644 vitamin D response element binding(GO:0070644)
0.0 0.1 GO:0008649 rRNA methyltransferase activity(GO:0008649)
0.0 0.1 GO:0050815 phosphoserine binding(GO:0050815)
0.0 0.1 GO:0048018 receptor agonist activity(GO:0048018)
0.0 0.1 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.0 0.2 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.0 0.2 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 0.1 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.0 0.0 GO:0043008 ATP-dependent protein binding(GO:0043008)
0.0 0.1 GO:0004774 succinate-CoA ligase activity(GO:0004774)
0.0 0.1 GO:0097506 uracil DNA N-glycosylase activity(GO:0004844) deaminated base DNA N-glycosylase activity(GO:0097506)
0.0 0.4 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.1 GO:0004465 lipoprotein lipase activity(GO:0004465)
0.0 0.1 GO:0097493 extracellular matrix constituent conferring elasticity(GO:0030023) structural molecule activity conferring elasticity(GO:0097493)
0.0 0.1 GO:0004568 chitinase activity(GO:0004568)
0.0 0.1 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0 0.0 GO:0003726 double-stranded RNA adenosine deaminase activity(GO:0003726)
0.0 0.1 GO:0005072 transforming growth factor beta receptor, cytoplasmic mediator activity(GO:0005072)
0.0 0.1 GO:0046923 ER retention sequence binding(GO:0046923)
0.0 0.1 GO:0030507 spectrin binding(GO:0030507)
0.0 0.1 GO:0004176 ATP-dependent peptidase activity(GO:0004176)
0.0 0.1 GO:0055103 ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106)
0.0 0.2 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031)
0.0 0.1 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.0 0.1 GO:0004815 aspartate-tRNA ligase activity(GO:0004815)
0.0 0.0 GO:0004311 farnesyltranstransferase activity(GO:0004311)
0.0 0.0 GO:0004946 bombesin receptor activity(GO:0004946)
0.0 0.1 GO:0005522 profilin binding(GO:0005522)
0.0 0.2 GO:0051018 protein kinase A binding(GO:0051018)
0.0 0.3 GO:0019198 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0 0.4 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 0.1 GO:0017110 nucleoside-diphosphatase activity(GO:0017110)
0.0 0.1 GO:0004528 phosphodiesterase I activity(GO:0004528)
0.0 0.1 GO:0017091 AU-rich element binding(GO:0017091)
0.0 0.1 GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.0 0.0 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 0.0 GO:0042608 T cell receptor binding(GO:0042608)
0.0 0.2 GO:0004697 protein kinase C activity(GO:0004697)
0.0 0.0 GO:0004924 oncostatin-M receptor activity(GO:0004924)
0.0 0.5 GO:0017048 Rho GTPase binding(GO:0017048)
0.0 0.0 GO:0000064 L-ornithine transmembrane transporter activity(GO:0000064)
0.0 0.1 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 0.0 GO:0050265 RNA uridylyltransferase activity(GO:0050265)
0.0 0.0 GO:0000247 C-8 sterol isomerase activity(GO:0000247)
0.0 0.1 GO:0015925 galactosidase activity(GO:0015925)
0.0 0.0 GO:0016748 succinyltransferase activity(GO:0016748)
0.0 0.4 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.0 0.1 GO:0036002 pre-mRNA binding(GO:0036002)
0.0 0.1 GO:0016778 diphosphotransferase activity(GO:0016778)
0.0 0.1 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 0.1 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.0 0.0 GO:0015057 thrombin receptor activity(GO:0015057)
0.0 0.1 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.0 0.0 GO:0070579 methylcytosine dioxygenase activity(GO:0070579)
0.0 0.0 GO:0008486 diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486)
0.0 0.1 GO:0030742 GTP-dependent protein binding(GO:0030742)
0.0 0.0 GO:0043024 ribosomal small subunit binding(GO:0043024)
0.0 0.0 GO:0016882 cyclo-ligase activity(GO:0016882)
0.0 0.0 GO:0035514 DNA demethylase activity(GO:0035514) DNA-N1-methyladenine dioxygenase activity(GO:0043734)
0.0 0.0 GO:0034713 type I transforming growth factor beta receptor binding(GO:0034713)
0.0 0.2 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.0 0.0 GO:0030229 very-low-density lipoprotein particle receptor activity(GO:0030229)
0.0 0.0 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0 0.1 GO:0008296 3'-5'-exodeoxyribonuclease activity(GO:0008296)
0.0 0.1 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.0 0.0 GO:0005030 neurotrophin receptor activity(GO:0005030)
0.0 0.0 GO:0070410 co-SMAD binding(GO:0070410)
0.0 0.1 GO:0030020 extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.0 0.0 GO:0052743 inositol tetrakisphosphate phosphatase activity(GO:0052743)
0.0 0.0 GO:0015252 hydrogen ion channel activity(GO:0015252)
0.0 0.2 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.1 GO:0048531 beta-1,3-galactosyltransferase activity(GO:0048531)
0.0 0.1 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0 0.0 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.0 0.0 GO:0000739 obsolete DNA strand annealing activity(GO:0000739)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.0 PID IL5 PATHWAY IL5-mediated signaling events
0.0 0.1 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.0 0.2 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 0.8 PID REELIN PATHWAY Reelin signaling pathway
0.0 1.0 ST T CELL SIGNAL TRANSDUCTION T Cell Signal Transduction
0.0 0.6 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 0.2 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.0 0.2 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.0 0.3 PID IL27 PATHWAY IL27-mediated signaling events
0.0 0.8 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 0.3 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.0 0.0 ST GA13 PATHWAY G alpha 13 Pathway
0.0 0.0 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.
0.0 0.0 PID AR NONGENOMIC PATHWAY Nongenotropic Androgen signaling
0.0 0.2 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.0 0.3 PID S1P S1P3 PATHWAY S1P3 pathway
0.0 0.1 PID VEGFR1 PATHWAY VEGFR1 specific signals
0.0 0.0 PID TCPTP PATHWAY Signaling events mediated by TCPTP
0.0 0.0 SIG PIP3 SIGNALING IN B LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.0 0.2 PID PI3K PLC TRK PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.0 0.1 PID TXA2PATHWAY Thromboxane A2 receptor signaling
0.0 0.2 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.1 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.0 0.1 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.0 0.2 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
0.0 0.0 REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.0 0.4 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0 0.4 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.4 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.0 0.2 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 0.1 REACTOME SEMA3A PAK DEPENDENT AXON REPULSION Genes involved in Sema3A PAK dependent Axon repulsion
0.0 0.3 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 0.3 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 0.0 REACTOME SPRY REGULATION OF FGF SIGNALING Genes involved in Spry regulation of FGF signaling
0.0 0.2 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.0 0.0 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 0.1 REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA Genes involved in G beta:gamma signalling through PLC beta
0.0 0.0 REACTOME GPVI MEDIATED ACTIVATION CASCADE Genes involved in GPVI-mediated activation cascade
0.0 0.1 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 0.2 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.0 0.2 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.2 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.0 0.1 REACTOME G PROTEIN BETA GAMMA SIGNALLING Genes involved in G-protein beta:gamma signalling
0.0 0.1 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.0 0.9 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 0.2 REACTOME ARMS MEDIATED ACTIVATION Genes involved in ARMS-mediated activation
0.0 0.3 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 0.0 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.0 0.3 REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.0 0.0 REACTOME REGULATED PROTEOLYSIS OF P75NTR Genes involved in Regulated proteolysis of p75NTR
0.0 0.1 REACTOME NRIF SIGNALS CELL DEATH FROM THE NUCLEUS Genes involved in NRIF signals cell death from the nucleus
0.0 0.4 REACTOME COSTIMULATION BY THE CD28 FAMILY Genes involved in Costimulation by the CD28 family
0.0 0.1 REACTOME DAG AND IP3 SIGNALING Genes involved in DAG and IP3 signaling
0.0 0.1 REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
0.0 0.2 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 0.1 REACTOME CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE Genes involved in Cell death signalling via NRAGE, NRIF and NADE
0.0 0.3 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.2 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 0.2 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 0.0 REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 Genes involved in Autodegradation of the E3 ubiquitin ligase COP1
0.0 0.1 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.2 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 0.0 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling