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ENCODE: H3K4me1 ChIP-Seq of primary human cells
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Results for ONECUT2_ONECUT3

Z-value: 0.73

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Transcription factors associated with ONECUT2_ONECUT3

Gene Symbol Gene ID Gene Info
ONECUT2
ENSG00000119547.5 one cut homeobox 2
ONECUT3
ENSG00000205922.4 one cut homeobox 3

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr18_55108780_55108995ONECUT227210.2861800.836.1e-03Click!
chr18_55102006_55102174ONECUT28270.4604080.761.7e-02Click!
chr18_55095518_55095669ONECUT273240.2112100.732.5e-02Click!
chr18_55094933_55095260ONECUT278210.2095830.732.6e-02Click!
chr18_55107329_55107636ONECUT241260.2347070.674.8e-02Click!
chr19_1766768_1766919ONECUT3144710.1146360.915.9e-04Click!
chr19_1767357_1767509ONECUT3150610.1133690.844.9e-03Click!
chr19_1748141_1748292ONECUT341560.1614570.791.2e-02Click!
chr19_1767075_1767264ONECUT3147970.1139350.761.7e-02Click!
chr19_1757254_1757405ONECUT349570.1465300.761.7e-02Click!

Activity of the ONECUT2_ONECUT3 motif across conditions

Conditions sorted by the z-value of the ONECUT2_ONECUT3 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr4_60477509_60477660 0.26 ENSG00000199780
 .
 78080
 0.12
chr2_128615982_128616171 0.25 POLR2D
 polymerase (RNA) II (DNA directed) polypeptide D
 345
 0.84
chr22_31680259_31680536 0.25 PIK3IP1
 phosphoinositide-3-kinase interacting protein 1
 7984
 0.11
chr2_143908158_143909031 0.24 RP11-190J23.1
21147
 0.22
chr7_85100293_85100580 0.22 SEMA3D
 sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D
 284265
 0.01
chr1_28383027_28383204 0.22 EYA3
 eyes absent homolog 3 (Drosophila)
 1483
 0.36
chr7_117623343_117623494 0.22 CTTNBP2
 cortactin binding protein 2
 109225
 0.07
chr12_96183797_96183948 0.21 NTN4
 netrin 4
 146
 0.94
chr2_197126192_197126464 0.21 AC020571.3
1171
 0.51
chr15_92536686_92536888 0.21 SLCO3A1
 solute carrier organic anion transporter family, member 3A1
 139436
 0.05
chr18_29601432_29601640 0.21 RNF125
 ring finger protein 125, E3 ubiquitin protein ligase
 3201
 0.21
chr14_61794008_61794159 0.20 PRKCH
 protein kinase C, eta
 452
 0.82
chr19_35696761_35697023 0.20 FAM187B
 family with sequence similarity 187, member B
 22740
 0.09
chr3_56832571_56832900 0.20 ARHGEF3
 Rho guanine nucleotide exchange factor (GEF) 3
 3242
 0.36
chr11_118327535_118327686 0.20 KMT2A
 lysine (K)-specific methyltransferase 2A
 20133
 0.1
chr8_71159622_71159862 0.20 NCOA2
 nuclear receptor coactivator 2
 2132
 0.43
chr10_8101739_8101961 0.20 GATA3
 GATA binding protein 3
 5081
 0.35
chr1_10965521_10965765 0.20 C1orf127
 chromosome 1 open reading frame 127
 42284
 0.13
chr13_49086706_49086857 0.20 RCBTB2
 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
 20432
 0.25
chr8_38216748_38217080 0.20 WHSC1L1
 Wolf-Hirschhorn syndrome candidate 1-like 1
 21425
 0.11
chr7_5498801_5498952 0.20 ENSG00000238394
 .
 26150
 0.11
chr10_124166786_124166937 0.19 ENSG00000265442
 .
 9620
 0.17
chr11_77346667_77346818 0.19 CLNS1A
 chloride channel, nucleotide-sensitive, 1A
 2054
 0.27
chr3_197438919_197439149 0.19 KIAA0226
 KIAA0226
 5967
 0.19
chr17_33859475_33859650 0.19 SLFN12L
 schlafen family member 12-like
 5318
 0.12
chr18_9401503_9401654 0.18 TWSG1
 twisted gastrulation BMP signaling modulator 1
 66730
 0.09
chr2_43242041_43242192 0.18 ENSG00000207087
 .
 76516
 0.11
chr9_123635625_123635776 0.18 PHF19
 PHD finger protein 19
 3011
 0.24
chr19_13057830_13057985 0.18 RAD23A
 RAD23 homolog A (S. cerevisiae)
 1201
 0.2
chr3_171174524_171174675 0.18 TNIK
 TRAF2 and NCK interacting kinase
 3253
 0.28
chr2_129171535_129171686 0.18 ENSG00000238379
 .
 31162
 0.21
chr14_20955468_20955676 0.17 PNP
 purine nucleoside phosphorylase
 16887
 0.08
chr2_60783510_60783862 0.17 BCL11A
 B-cell CLL/lymphoma 11A (zinc finger protein)
 2984
 0.32
chr3_44063750_44064016 0.17 ENSG00000252980
 .
 48696
 0.17
chr15_81868847_81868998 0.17 TMC3
 transmembrane channel-like 3
 202368
 0.02
chr8_66751621_66751772 0.17 PDE7A
 phosphodiesterase 7A
 713
 0.79
chr20_61158658_61158954 0.17 ENSG00000207764
 .
 3313
 0.17
chr1_9820007_9820303 0.17 CLSTN1
 calsyntenin 1
 8516
 0.19
chr15_55582560_55582711 0.17 RAB27A
 RAB27A, member RAS oncogene family
 634
 0.71
chrX_134670567_134670912 0.16 DDX26B-AS1
 DDX26B antisense RNA 1
 16140
 0.17
chr2_233702526_233702728 0.16 GIGYF2
 GRB10 interacting GYF protein 2
 5043
 0.16
chr3_170971538_170971689 0.16 TNIK
 TRAF2 and NCK interacting kinase
 28113
 0.24
chr1_23498297_23498448 0.16 LUZP1
 leucine zipper protein 1
 3021
 0.19
chr17_55674101_55674386 0.16 RP11-118E18.4
11530
 0.2
chr15_55094341_55094492 0.16 UNC13C
 unc-13 homolog C (C. elegans)
 190743
 0.03
chr4_39638786_39639138 0.16 SMIM14
 small integral membrane protein 14
 1551
 0.38
chr14_22992320_22992591 0.16 TRAJ15
 T cell receptor alpha joining 15
 6125
 0.12
chr13_47166965_47167233 0.16 LRCH1
 leucine-rich repeats and calponin homology (CH) domain containing 1
 39704
 0.2
chr7_150181541_150181756 0.16 GIMAP7
 GTPase, IMAP family member 7
 30270
 0.14
chr12_95586062_95586213 0.16 FGD6
 FYVE, RhoGEF and PH domain containing 6
 25018
 0.16
chr18_72706840_72706991 0.16 ZADH2
 zinc binding alcohol dehydrogenase domain containing 2
 210553
 0.02
chr5_54391771_54392054 0.16 GZMA
 granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
 6564
 0.16
chr20_19915209_19915430 0.16 RIN2
 Ras and Rab interactor 2
 45109
 0.16
chr10_95242141_95242412 0.16 MYOF
 myoferlin
 202
 0.94
chr10_63660538_63660964 0.16 ARID5B
 AT rich interactive domain 5B (MRF1-like)
 308
 0.93
chr1_172863548_172863829 0.16 TNFSF18
 tumor necrosis factor (ligand) superfamily, member 18
 156368
 0.04
chr1_100865575_100865838 0.16 ENSG00000216067
 .
 21375
 0.18
chr4_153770648_153770924 0.16 ENSG00000252375
 .
 51332
 0.13
chr12_15116052_15116331 0.16 ARHGDIB
 Rho GDP dissociation inhibitor (GDI) beta
 1529
 0.36
chr5_56116227_56116445 0.16 MAP3K1
 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
 4935
 0.21
chr14_92973076_92973375 0.15 RIN3
 Ras and Rab interactor 3
 6893
 0.29
chr8_8188515_8188792 0.15 SGK223
 Tyrosine-protein kinase SgK223
 50604
 0.14
chr2_24115618_24115777 0.15 ATAD2B
 ATPase family, AAA domain containing 2B
 24940
 0.18
chr15_41577968_41578223 0.15 CHP1
 calcineurin-like EF-hand protein 1
 28987
 0.12
chr3_32464580_32465078 0.15 CMTM7
 CKLF-like MARVEL transmembrane domain containing 7
 31298
 0.19
chr9_117355021_117355172 0.15 ATP6V1G1
 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1
 5070
 0.16
chr1_166672607_166672758 0.15 POGK
 pogo transposable element with KRAB domain
 135999
 0.05
chr13_91179830_91179981 0.15 ENSG00000251753
 .
 254218
 0.02
chr11_36522618_36522914 0.15 TRAF6
 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
 9040
 0.22
chr2_179912550_179912701 0.15 CCDC141
 coiled-coil domain containing 141
 2161
 0.36
chr6_53406439_53406590 0.15 GCLC
 glutamate-cysteine ligase, catalytic subunit
 2892
 0.28
chr3_71632244_71632475 0.15 FOXP1
 forkhead box P1
 545
 0.79
chr1_31986580_31986731 0.15 ENSG00000206981
 .
 16130
 0.16
chr11_104940908_104941107 0.15 CARD16
 caspase recruitment domain family, member 16
 24904
 0.15
chr10_7298232_7298383 0.15 SFMBT2
 Scm-like with four mbt domains 2
 152400
 0.04
chr16_11188483_11188858 0.15 RP11-66H6.3
23711
 0.16
chr3_5057035_5057190 0.15 BHLHE40-AS1
 BHLHE40 antisense RNA 1
 35466
 0.15
chr4_33186380_33186531 0.15 ENSG00000265035
 .
 351911
 0.01
chr5_61573652_61573803 0.15 KIF2A
 kinesin heavy chain member 2A
 28262
 0.23
chr1_244001324_244001616 0.15 AKT3
 v-akt murine thymoma viral oncogene homolog 3
 5068
 0.28
chr18_43791376_43791983 0.15 C18orf25
 chromosome 18 open reading frame 25
 37679
 0.17
chr6_147525970_147526206 0.15 STXBP5-AS1
 STXBP5 antisense RNA 1
 338
 0.57
chr9_125662422_125663045 0.15 RC3H2
 ring finger and CCCH-type domains 2
 2344
 0.19
chr15_92644884_92645035 0.15 RP11-24J19.1
70707
 0.13
chr6_154893428_154893579 0.15 CNKSR3
 CNKSR family member 3
 61710
 0.15
chr9_108462475_108462626 0.14 TMEM38B
 transmembrane protein 38B
 715
 0.75
chr3_56903065_56903308 0.14 ARHGEF3
 Rho guanine nucleotide exchange factor (GEF) 3
 47313
 0.16
chr11_58612469_58612620 0.14 GLYATL2
 glycine-N-acyltransferase-like 2
 287
 0.91
chr12_66690757_66690908 0.14 ENSG00000222744
 .
 4369
 0.19
chr15_70877190_70877341 0.14 UACA
 uveal autoantigen with coiled-coil domains and ankyrin repeats
 117355
 0.06
chr15_43205982_43206133 0.14 TTBK2
 tau tubulin kinase 2
 5584
 0.28
chr1_230415219_230415370 0.14 RP5-956O18.3
2345
 0.34
chr14_100689278_100689429 0.14 YY1
 YY1 transcription factor
 15282
 0.11
chr13_107526119_107526366 0.14 ENSG00000239050
 .
 101132
 0.08
chr6_53156340_53156626 0.14 ENSG00000264056
 .
 14692
 0.19
chr13_99857518_99857964 0.14 ENSG00000201793
 .
 221
 0.93
chr3_3232658_3232809 0.14 CRBN
 cereblon
 11339
 0.21
chr1_117313577_117313728 0.14 CD2
 CD2 molecule
 16563
 0.21
chr6_12324816_12324967 0.14 EDN1
 endothelin 1
 34295
 0.22
chr3_23875536_23875687 0.13 UBE2E1
 ubiquitin-conjugating enzyme E2E 1
 22662
 0.17
chr20_40238845_40239072 0.13 CHD6
 chromodomain helicase DNA binding protein 6
 4454
 0.29
chr2_161262836_161263025 0.13 ENSG00000263948
 .
 1463
 0.33
chr7_65196369_65196552 0.13 CCT6P1
 chaperonin containing TCP1, subunit 6 (zeta) pseudogene 1
 19669
 0.15
chr6_119255106_119255516 0.13 MCM9
 minichromosome maintenance complex component 9
 330
 0.7
chr7_78915738_78915889 0.13 ENSG00000212482
 .
 56875
 0.16
chr1_222794325_222794476 0.13 MIA3
 melanoma inhibitory activity family, member 3
 2950
 0.22
chr17_48501050_48501201 0.13 ACSF2
 acyl-CoA synthetase family member 2
 2394
 0.17
chr18_21406136_21407050 0.13 LAMA3
 laminin, alpha 3
 7324
 0.26
chr15_91143361_91143512 0.13 CTD-3065B20.2
3757
 0.19
chr22_23218111_23218262 0.13 IGLV3-2
 immunoglobulin lambda variable 3-2 (pseudogene)
 2795
 0.07
chr7_150300875_150301266 0.13 GIMAP6
 GTPase, IMAP family member 6
 28364
 0.15
chr6_26189961_26190186 0.13 HIST1H4D
 histone cluster 1, H4d
 769
 0.33
chr17_66181792_66181975 0.13 LRRC37A16P
 leucine rich repeat containing 37, member A16, pseudogene
 33274
 0.14
chr6_139612233_139612724 0.13 TXLNB
 taxilin beta
 798
 0.66
chr16_89425528_89425713 0.13 ANKRD11
 ankyrin repeat domain 11
 30226
 0.11
chr7_56101315_56101548 0.13 PSPH
 phosphoserine phosphatase
 418
 0.75
chrX_119588396_119588571 0.13 LAMP2
 lysosomal-associated membrane protein 2
 14364
 0.22
chr10_73059409_73059560 0.13 SLC29A3
 solute carrier family 29 (equilibrative nucleoside transporter), member 3
 19531
 0.18
chr10_86094464_86094669 0.13 CCSER2
 coiled-coil serine-rich protein 2
 6147
 0.27
chr8_120219756_120219907 0.13 MAL2
 mal, T-cell differentiation protein 2 (gene/pseudogene)
 779
 0.76
chr4_109352208_109352359 0.13 ENSG00000266046
 .
 146013
 0.04
chr6_6386672_6386823 0.13 F13A1
 coagulation factor XIII, A1 polypeptide
 65501
 0.13
chr1_184081330_184081481 0.13 ENSG00000199840
 .
 59552
 0.12
chr5_123395807_123395958 0.13 CSNK1G3
 casein kinase 1, gamma 3
 471763
 0.01
chr6_2127389_2127540 0.13 GMDS
 GDP-mannose 4,6-dehydratase
 48761
 0.2
chr3_50662504_50662845 0.13 MAPKAPK3
 mitogen-activated protein kinase-activated protein kinase 3
 7853
 0.15
chr1_247489619_247489770 0.13 ZNF496
 zinc finger protein 496
 2853
 0.26
chr6_25405524_25405816 0.13 ENSG00000253017
 .
 2453
 0.28
chr14_50317979_50318647 0.13 NEMF
 nuclear export mediator factor
 1185
 0.29
chr2_54818302_54818646 0.13 SPTBN1
 spectrin, beta, non-erythrocytic 1
 32943
 0.15
chr12_8101245_8101532 0.13 SLC2A3
 solute carrier family 2 (facilitated glucose transporter), member 3
 12517
 0.15
chr7_2920385_2920536 0.13 GNA12
 guanine nucleotide binding protein (G protein) alpha 12
 36502
 0.16
chr3_142682236_142682387 0.13 PAQR9
 progestin and adipoQ receptor family member IX
 133
 0.82
chr1_67575967_67576118 0.13 ENSG00000252433
 .
 7580
 0.18
chrX_78412182_78412333 0.13 GPR174
 G protein-coupled receptor 174
 14212
 0.31
chr20_36667703_36667854 0.13 RPRD1B
 regulation of nuclear pre-mRNA domain containing 1B
 5830
 0.17
chrX_119592645_119592909 0.12 LAMP2
 lysosomal-associated membrane protein 2
 10070
 0.23
chr9_38070649_38070800 0.12 SHB
 Src homology 2 domain containing adaptor protein B
 1514
 0.5
chr15_66750716_66750867 0.12 MAP2K1
 mitogen-activated protein kinase kinase 1
 4999
 0.11
chr16_76699686_76699837 0.12 RP11-58C22.1
 Uncharacterized protein
 112447
 0.07
chr1_232929880_232930031 0.12 MAP10
 microtubule-associated protein 10
 10688
 0.25
chr13_29101657_29101953 0.12 FLT1
 fms-related tyrosine kinase 1
 32540
 0.22
chr19_16571262_16571413 0.12 EPS15L1
 epidermal growth factor receptor pathway substrate 15-like 1
 11417
 0.12
chr6_88541623_88541774 0.12 ENSG00000207131
 .
 5695
 0.2
chr6_25442292_25442443 0.12 ENSG00000238322
 .
 6859
 0.22
chr2_122405151_122406002 0.12 CLASP1
 cytoplasmic linker associated protein 1
 1476
 0.32
chrX_70585571_70585723 0.12 TAF1
 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
 467
 0.83
chr2_26017998_26018199 0.12 ASXL2
 additional sex combs like 2 (Drosophila)
 14920
 0.24
chr9_120588985_120589386 0.12 ENSG00000251847
 .
 95436
 0.08
chr6_15400503_15400654 0.12 JARID2
 jumonji, AT rich interactive domain 2
 511
 0.85
chr6_118570742_118570893 0.12 PLN
 phospholamban
 298644
 0.01
chr9_93626346_93626497 0.12 SYK
 spleen tyrosine kinase
 36651
 0.24
chr19_12844114_12844270 0.12 C19orf43
 chromosome 19 open reading frame 43
 1288
 0.2
chr9_92108756_92109116 0.12 SEMA4D
 sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
 3411
 0.27
chr12_21832380_21832693 0.12 RP11-59N23.3
17289
 0.18
chr1_198146103_198146254 0.12 NEK7
 NIMA-related kinase 7
 19927
 0.29
chr9_3523924_3524075 0.12 RFX3
 regulatory factor X, 3 (influences HLA class II expression)
 1984
 0.45
chr12_89763940_89764091 0.12 DUSP6
 dual specificity phosphatase 6
 16967
 0.24
chr14_91863332_91863575 0.12 CCDC88C
 coiled-coil domain containing 88C
 20237
 0.21
chr11_35822778_35822929 0.12 RP11-698N11.4
13029
 0.23
chr19_2608004_2608206 0.12 CTC-265F19.2
3755
 0.18
chr10_43898812_43898963 0.12 HNRNPF
 heterogeneous nuclear ribonucleoprotein F
 4380
 0.18
chr15_96539880_96540048 0.12 NR2F2-AS1
 NR2F2 antisense RNA 1
 226320
 0.02
chrX_12979344_12979749 0.12 TMSB4X
 thymosin beta 4, X-linked
 13681
 0.21
chr2_103289356_103289507 0.12 SLC9A2
 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
 53265
 0.13
chr3_51597694_51597897 0.12 RAD54L2
 RAD54-like 2 (S. cerevisiae)
 22199
 0.17
chr14_55035050_55035201 0.12 SAMD4A
 sterile alpha motif domain containing 4A
 488
 0.84
chr4_153354722_153354873 0.12 FBXW7
 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
 21039
 0.21
chr4_55685762_55685928 0.12 KIT
 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
 161760
 0.04
chr3_166163700_166163851 0.12 ENSG00000251759
 .
 224135
 0.02
chrX_54442885_54443036 0.12 TSR2
 TSR2, 20S rRNA accumulation, homolog (S. cerevisiae)
 23874
 0.19
chr10_126234282_126234537 0.12 LHPP
 phospholysine phosphohistidine inorganic pyrophosphate phosphatase
 83997
 0.08
chr1_144084731_144084882 0.12 NBPF8
 neuroblastoma breakpoint family, member 8
 62002
 0.13
chr3_45005575_45005726 0.12 ZDHHC3
 zinc finger, DHHC-type containing 3
 12008
 0.15
chr12_7906549_7906700 0.12 CLEC4C
 C-type lectin domain family 4, member C
 2423
 0.19
chr4_71572054_71572676 0.11 RUFY3
 RUN and FYVE domain containing 3
 1847
 0.19
chr7_80547947_80548212 0.11 SEMA3C
 sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
 420
 0.92
chr5_122885697_122885899 0.11 CSNK1G3
 casein kinase 1, gamma 3
 4470
 0.3
chr21_19162869_19163124 0.11 AL109761.5
2809
 0.31
chr7_143333727_143333976 0.11 FAM115C
 family with sequence similarity 115, member C
 15306
 0.19
chr1_111762611_111763176 0.11 CHI3L2
 chitinase 3-like 2
 6745
 0.14
chr2_65390128_65390454 0.11 ENSG00000272025
 .
 4495
 0.24
chr1_68101529_68101856 0.11 ENSG00000242482
 .
 21120
 0.21
chr16_17468478_17468629 0.11 XYLT1
 xylosyltransferase I
 96185
 0.09
chr10_12110496_12110658 0.11 DHTKD1
 dehydrogenase E1 and transketolase domain containing 1
 394
 0.83
chr6_16162236_16162478 0.11 ENSG00000251793
 .
 13681
 0.16
chr1_67636156_67636590 0.11 IL23R
 interleukin 23 receptor
 4204
 0.2
chr15_64105699_64105850 0.11 HERC1
 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
 20310
 0.21
chr8_79423337_79423629 0.11 PKIA
 protein kinase (cAMP-dependent, catalytic) inhibitor alpha
 4891
 0.32
chr6_108686448_108686599 0.11 ENSG00000200799
 .
 26754
 0.18
chr16_12174266_12174426 0.11 RP11-276H1.3
9813
 0.16
chr7_138309701_138309924 0.11 ENSG00000252188
 .
 112
 0.97
chrX_47411122_47411273 0.11 ARAF
 v-raf murine sarcoma 3611 viral oncogene homolog
 9319
 0.15
chr6_34906018_34906169 0.11 ANKS1A
 ankyrin repeat and sterile alpha motif domain containing 1A
 49013
 0.13
chr22_40783696_40783896 0.11 RP5-1042K10.10
425
 0.81
chr1_93971516_93971910 0.11 ENSG00000212601
 .
 17704
 0.18
chr13_73144148_73144299 0.11 ENSG00000199282
 .
 16595
 0.24
chr16_28146383_28146648 0.11 XPO6
 exportin 6
 23304
 0.17
chr4_22515546_22516022 0.11 GPR125
 G protein-coupled receptor 125
 1836
 0.52
chr10_74578727_74578925 0.11 RP11-354E23.5
52508
 0.12

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of ONECUT2_ONECUT3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
0.1 0.2 GO:0001778 plasma membrane repair(GO:0001778)
0.0 0.1 GO:0002323 natural killer cell activation involved in immune response(GO:0002323) natural killer cell degranulation(GO:0043320)
0.0 0.2 GO:0051570 regulation of histone H3-K9 methylation(GO:0051570)
0.0 0.1 GO:0003215 cardiac right ventricle morphogenesis(GO:0003215)
0.0 0.2 GO:0007256 activation of JNKK activity(GO:0007256)
0.0 0.1 GO:0010761 fibroblast migration(GO:0010761)
0.0 0.1 GO:0016576 histone dephosphorylation(GO:0016576)
0.0 0.1 GO:0002329 immature B cell differentiation(GO:0002327) pre-B cell differentiation(GO:0002329)
0.0 0.1 GO:0070340 detection of bacterial lipoprotein(GO:0042494) detection of bacterial lipopeptide(GO:0070340)
0.0 0.1 GO:0036037 CD8-positive, alpha-beta T cell activation(GO:0036037) CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0 0.1 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.0 0.1 GO:0001911 negative regulation of leukocyte mediated cytotoxicity(GO:0001911)
0.0 0.1 GO:0019731 antibacterial humoral response(GO:0019731)
0.0 0.1 GO:0035405 histone-threonine phosphorylation(GO:0035405)
0.0 0.1 GO:0003323 type B pancreatic cell development(GO:0003323)
0.0 0.1 GO:0060261 positive regulation of transcription initiation from RNA polymerase II promoter(GO:0060261) positive regulation of DNA-templated transcription, initiation(GO:2000144)
0.0 0.1 GO:0032823 regulation of natural killer cell differentiation(GO:0032823) positive regulation of natural killer cell differentiation(GO:0032825)
0.0 0.1 GO:0061154 endothelial tube morphogenesis(GO:0061154)
0.0 0.1 GO:0044256 multicellular organismal protein catabolic process(GO:0044254) protein digestion(GO:0044256) multicellular organismal macromolecule catabolic process(GO:0044266) multicellular organismal protein metabolic process(GO:0044268)
0.0 0.1 GO:0003056 regulation of vascular smooth muscle contraction(GO:0003056)
0.0 0.0 GO:0042520 tyrosine phosphorylation of Stat4 protein(GO:0042504) regulation of tyrosine phosphorylation of Stat4 protein(GO:0042519) positive regulation of tyrosine phosphorylation of Stat4 protein(GO:0042520)
0.0 0.1 GO:0006491 N-glycan processing(GO:0006491)
0.0 0.1 GO:0016584 nucleosome positioning(GO:0016584)
0.0 0.1 GO:0019987 obsolete negative regulation of anti-apoptosis(GO:0019987)
0.0 0.0 GO:0060585 regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
0.0 0.0 GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II(GO:0019886)
0.0 0.0 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.0 0.0 GO:0046643 regulation of gamma-delta T cell differentiation(GO:0045586) positive regulation of gamma-delta T cell differentiation(GO:0045588) regulation of gamma-delta T cell activation(GO:0046643) positive regulation of gamma-delta T cell activation(GO:0046645)
0.0 0.1 GO:0051409 response to nitrosative stress(GO:0051409)
0.0 0.1 GO:0072131 kidney mesenchyme morphogenesis(GO:0072131) metanephric mesenchyme morphogenesis(GO:0072133)
0.0 0.0 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.0 0.1 GO:0002903 negative regulation of B cell apoptotic process(GO:0002903)
0.0 0.0 GO:0071569 protein ufmylation(GO:0071569)
0.0 0.0 GO:0048388 endosomal lumen acidification(GO:0048388)
0.0 0.1 GO:0001553 luteinization(GO:0001553)
0.0 0.0 GO:0006667 sphinganine metabolic process(GO:0006667)
0.0 0.0 GO:0002313 mature B cell differentiation involved in immune response(GO:0002313)
0.0 0.0 GO:0070634 transepithelial ammonium transport(GO:0070634)
0.0 0.0 GO:0006434 seryl-tRNA aminoacylation(GO:0006434)
0.0 0.0 GO:0018206 peptidyl-methionine modification(GO:0018206)
0.0 0.0 GO:0000491 small nucleolar ribonucleoprotein complex assembly(GO:0000491) box C/D snoRNP assembly(GO:0000492)
0.0 0.1 GO:0010887 negative regulation of cholesterol storage(GO:0010887)
0.0 0.1 GO:0000729 DNA double-strand break processing(GO:0000729)
0.0 0.0 GO:0007571 age-dependent response to oxidative stress(GO:0001306) age-dependent general metabolic decline(GO:0007571)
0.0 0.1 GO:0031529 ruffle organization(GO:0031529)
0.0 0.1 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.0 0.1 GO:0002860 natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002420) natural killer cell mediated immune response to tumor cell(GO:0002423) regulation of natural killer cell mediated immune response to tumor cell(GO:0002855) positive regulation of natural killer cell mediated immune response to tumor cell(GO:0002857) regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002858) positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002860)
0.0 0.1 GO:0055075 potassium ion homeostasis(GO:0055075)
0.0 0.0 GO:0001955 blood vessel maturation(GO:0001955)
0.0 0.0 GO:0006172 ADP biosynthetic process(GO:0006172) purine nucleoside diphosphate biosynthetic process(GO:0009136) purine ribonucleoside diphosphate biosynthetic process(GO:0009180) ribonucleoside diphosphate biosynthetic process(GO:0009188)
0.0 0.0 GO:0010956 negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137)
0.0 0.0 GO:0001821 histamine secretion(GO:0001821)
0.0 0.1 GO:0001561 fatty acid alpha-oxidation(GO:0001561)
0.0 0.1 GO:0010507 negative regulation of autophagy(GO:0010507)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0031088 platelet dense granule membrane(GO:0031088)
0.0 0.2 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 0.1 GO:0031932 TORC2 complex(GO:0031932)
0.0 0.2 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 0.2 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.0 0.1 GO:0048786 presynaptic active zone(GO:0048786)
0.0 0.0 GO:0031904 endosome lumen(GO:0031904)
0.0 0.0 GO:0071664 catenin-TCF7L2 complex(GO:0071664)
0.0 0.1 GO:0031371 ubiquitin conjugating enzyme complex(GO:0031371)
0.0 0.1 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.0 GO:0002139 stereocilia coupling link(GO:0002139) stereocilia ankle link(GO:0002141) stereocilia ankle link complex(GO:0002142)
0.0 0.1 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 0.0 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.0 0.0 GO:0098984 asymmetric synapse(GO:0032279) neuron to neuron synapse(GO:0098984)
0.0 0.0 GO:0000300 obsolete peripheral to membrane of membrane fraction(GO:0000300)
0.0 0.0 GO:0071942 XPC complex(GO:0071942)
0.0 0.1 GO:0090533 cation-transporting ATPase complex(GO:0090533)
0.0 0.1 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.0 0.1 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 0.0 GO:0032444 activin responsive factor complex(GO:0032444)
0.0 0.0 GO:0038201 TORC1 complex(GO:0031931) TOR complex(GO:0038201)
0.0 0.0 GO:0005947 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0030375 thyroid hormone receptor coactivator activity(GO:0030375)
0.0 0.1 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.1 GO:0047961 glycine N-acyltransferase activity(GO:0047961)
0.0 0.1 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.0 0.2 GO:0043237 laminin-1 binding(GO:0043237)
0.0 0.1 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0 0.4 GO:0004697 protein kinase C activity(GO:0004697)
0.0 0.1 GO:0004013 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0 0.1 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.0 0.2 GO:0032452 histone demethylase activity(GO:0032452)
0.0 0.1 GO:0008900 hydrogen:potassium-exchanging ATPase activity(GO:0008900)
0.0 0.1 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 0.1 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0 0.1 GO:0008241 peptidyl-dipeptidase activity(GO:0008241)
0.0 0.1 GO:0043515 kinetochore binding(GO:0043515)
0.0 0.1 GO:0008545 JUN kinase kinase activity(GO:0008545)
0.0 0.1 GO:0004470 malic enzyme activity(GO:0004470)
0.0 0.1 GO:0034186 apolipoprotein A-I binding(GO:0034186)
0.0 0.0 GO:0071723 lipopeptide binding(GO:0071723)
0.0 0.1 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 0.1 GO:0030371 translation repressor activity(GO:0030371)
0.0 0.2 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.1 GO:0043422 protein kinase B binding(GO:0043422)
0.0 0.1 GO:0031491 nucleosome binding(GO:0031491)
0.0 0.0 GO:0043142 single-stranded DNA-dependent ATPase activity(GO:0043142)
0.0 0.0 GO:0031705 bombesin receptor binding(GO:0031705) endothelin B receptor binding(GO:0031708)
0.0 0.1 GO:0051637 obsolete Gram-positive bacterial cell surface binding(GO:0051637)
0.0 0.0 GO:0004828 serine-tRNA ligase activity(GO:0004828)
0.0 0.0 GO:0004677 DNA-dependent protein kinase activity(GO:0004677)
0.0 0.1 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 0.0 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0 0.0 GO:0005148 prolactin receptor binding(GO:0005148)
0.0 0.1 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.0 0.1 GO:0008266 poly(U) RNA binding(GO:0008266)
0.0 0.1 GO:0001671 ATPase activator activity(GO:0001671)
0.0 0.0 GO:0004505 phenylalanine 4-monooxygenase activity(GO:0004505)
0.0 0.0 GO:0004758 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0 0.0 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME VIRAL MESSENGER RNA SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.0 0.3 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 0.1 REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.0 0.1 REACTOME ELONGATION ARREST AND RECOVERY Genes involved in Elongation arrest and recovery