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ENCODE: H3K4me1 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for ONECUT2_ONECUT3

Z-value: 0.73

Motif logo

Transcription factors associated with ONECUT2_ONECUT3

Gene Symbol	Gene ID	Gene Info
ONECUT2 Ensembl NCBI GeneCards UniProt	ENSG00000119547.5	ONECUT2
ONECUT3 Ensembl NCBI GeneCards UniProt	ENSG00000205922.4	ONECUT3

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
ONECUT2	chr18_55108780_55108995	2721	0.286180	0.83	6.1e-03	Click!
ONECUT2	chr18_55102006_55102174	827	0.460408	0.76	1.7e-02	Click!
ONECUT2	chr18_55095518_55095669	7324	0.211210	0.73	2.5e-02	Click!
ONECUT2	chr18_55094933_55095260	7821	0.209583	0.73	2.6e-02	Click!
ONECUT2	chr18_55107329_55107636	4126	0.234707	0.67	4.8e-02	Click!
ONECUT3	chr19_1766768_1766919	14471	0.114636	0.91	5.9e-04	Click!
ONECUT3	chr19_1767357_1767509	15061	0.113369	0.84	4.9e-03	Click!
ONECUT3	chr19_1748141_1748292	4156	0.161457	0.79	1.2e-02	Click!
ONECUT3	chr19_1767075_1767264	14797	0.113935	0.76	1.7e-02	Click!
ONECUT3	chr19_1757254_1757405	4957	0.146530	0.76	1.7e-02	Click!

Activity of the ONECUT2_ONECUT3 motif across conditions

Conditions sorted by the z-value of the ONECUT2_ONECUT3 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr4_60477509_60477660	0.26	ENSG00000199780	.	78080	0.12
chr2_128615982_128616171	0.25	POLR2D	polymerase (RNA) II (DNA directed) polypeptide D	345	0.84
chr22_31680259_31680536	0.25	PIK3IP1	phosphoinositide-3-kinase interacting protein 1	7984	0.11
chr2_143908158_143909031	0.24	RP11-190J23.1		21147	0.22
chr7_85100293_85100580	0.22	SEMA3D	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D	284265	0.01
chr1_28383027_28383204	0.22	EYA3	eyes absent homolog 3 (Drosophila)	1483	0.36
chr7_117623343_117623494	0.22	CTTNBP2	cortactin binding protein 2	109225	0.07
chr12_96183797_96183948	0.21	NTN4	netrin 4	146	0.94
chr2_197126192_197126464	0.21	AC020571.3		1171	0.51
chr15_92536686_92536888	0.21	SLCO3A1	solute carrier organic anion transporter family, member 3A1	139436	0.05
chr18_29601432_29601640	0.21	RNF125	ring finger protein 125, E3 ubiquitin protein ligase	3201	0.21
chr14_61794008_61794159	0.20	PRKCH	protein kinase C, eta	452	0.82
chr19_35696761_35697023	0.20	FAM187B	family with sequence similarity 187, member B	22740	0.09
chr3_56832571_56832900	0.20	ARHGEF3	Rho guanine nucleotide exchange factor (GEF) 3	3242	0.36
chr11_118327535_118327686	0.20	KMT2A	lysine (K)-specific methyltransferase 2A	20133	0.1
chr8_71159622_71159862	0.20	NCOA2	nuclear receptor coactivator 2	2132	0.43
chr10_8101739_8101961	0.20	GATA3	GATA binding protein 3	5081	0.35
chr1_10965521_10965765	0.20	C1orf127	chromosome 1 open reading frame 127	42284	0.13
chr13_49086706_49086857	0.20	RCBTB2	regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2	20432	0.25
chr8_38216748_38217080	0.20	WHSC1L1	Wolf-Hirschhorn syndrome candidate 1-like 1	21425	0.11
chr7_5498801_5498952	0.20	ENSG00000238394	.	26150	0.11
chr10_124166786_124166937	0.19	ENSG00000265442	.	9620	0.17
chr11_77346667_77346818	0.19	CLNS1A	chloride channel, nucleotide-sensitive, 1A	2054	0.27
chr3_197438919_197439149	0.19	KIAA0226	KIAA0226	5967	0.19
chr17_33859475_33859650	0.19	SLFN12L	schlafen family member 12-like	5318	0.12
chr18_9401503_9401654	0.18	TWSG1	twisted gastrulation BMP signaling modulator 1	66730	0.09
chr2_43242041_43242192	0.18	ENSG00000207087	.	76516	0.11
chr9_123635625_123635776	0.18	PHF19	PHD finger protein 19	3011	0.24
chr19_13057830_13057985	0.18	RAD23A	RAD23 homolog A (S. cerevisiae)	1201	0.2
chr3_171174524_171174675	0.18	TNIK	TRAF2 and NCK interacting kinase	3253	0.28
chr2_129171535_129171686	0.18	ENSG00000238379	.	31162	0.21
chr14_20955468_20955676	0.17	PNP	purine nucleoside phosphorylase	16887	0.08
chr2_60783510_60783862	0.17	BCL11A	B-cell CLL/lymphoma 11A (zinc finger protein)	2984	0.32
chr3_44063750_44064016	0.17	ENSG00000252980	.	48696	0.17
chr15_81868847_81868998	0.17	TMC3	transmembrane channel-like 3	202368	0.02
chr8_66751621_66751772	0.17	PDE7A	phosphodiesterase 7A	713	0.79
chr20_61158658_61158954	0.17	ENSG00000207764	.	3313	0.17
chr1_9820007_9820303	0.17	CLSTN1	calsyntenin 1	8516	0.19
chr15_55582560_55582711	0.17	RAB27A	RAB27A, member RAS oncogene family	634	0.71
chrX_134670567_134670912	0.16	DDX26B-AS1	DDX26B antisense RNA 1	16140	0.17
chr2_233702526_233702728	0.16	GIGYF2	GRB10 interacting GYF protein 2	5043	0.16
chr3_170971538_170971689	0.16	TNIK	TRAF2 and NCK interacting kinase	28113	0.24
chr1_23498297_23498448	0.16	LUZP1	leucine zipper protein 1	3021	0.19
chr17_55674101_55674386	0.16	RP11-118E18.4		11530	0.2
chr15_55094341_55094492	0.16	UNC13C	unc-13 homolog C (C. elegans)	190743	0.03
chr4_39638786_39639138	0.16	SMIM14	small integral membrane protein 14	1551	0.38
chr14_22992320_22992591	0.16	TRAJ15	T cell receptor alpha joining 15	6125	0.12
chr13_47166965_47167233	0.16	LRCH1	leucine-rich repeats and calponin homology (CH) domain containing 1	39704	0.2
chr7_150181541_150181756	0.16	GIMAP7	GTPase, IMAP family member 7	30270	0.14
chr12_95586062_95586213	0.16	FGD6	FYVE, RhoGEF and PH domain containing 6	25018	0.16
chr18_72706840_72706991	0.16	ZADH2	zinc binding alcohol dehydrogenase domain containing 2	210553	0.02
chr5_54391771_54392054	0.16	GZMA	granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)	6564	0.16
chr20_19915209_19915430	0.16	RIN2	Ras and Rab interactor 2	45109	0.16
chr10_95242141_95242412	0.16	MYOF	myoferlin	202	0.94
chr10_63660538_63660964	0.16	ARID5B	AT rich interactive domain 5B (MRF1-like)	308	0.93
chr1_172863548_172863829	0.16	TNFSF18	tumor necrosis factor (ligand) superfamily, member 18	156368	0.04
chr1_100865575_100865838	0.16	ENSG00000216067	.	21375	0.18
chr4_153770648_153770924	0.16	ENSG00000252375	.	51332	0.13
chr12_15116052_15116331	0.16	ARHGDIB	Rho GDP dissociation inhibitor (GDI) beta	1529	0.36
chr5_56116227_56116445	0.16	MAP3K1	mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase	4935	0.21
chr14_92973076_92973375	0.15	RIN3	Ras and Rab interactor 3	6893	0.29
chr8_8188515_8188792	0.15	SGK223	Tyrosine-protein kinase SgK223	50604	0.14
chr2_24115618_24115777	0.15	ATAD2B	ATPase family, AAA domain containing 2B	24940	0.18
chr15_41577968_41578223	0.15	CHP1	calcineurin-like EF-hand protein 1	28987	0.12
chr3_32464580_32465078	0.15	CMTM7	CKLF-like MARVEL transmembrane domain containing 7	31298	0.19
chr9_117355021_117355172	0.15	ATP6V1G1	ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1	5070	0.16
chr1_166672607_166672758	0.15	POGK	pogo transposable element with KRAB domain	135999	0.05
chr13_91179830_91179981	0.15	ENSG00000251753	.	254218	0.02
chr11_36522618_36522914	0.15	TRAF6	TNF receptor-associated factor 6, E3 ubiquitin protein ligase	9040	0.22
chr2_179912550_179912701	0.15	CCDC141	coiled-coil domain containing 141	2161	0.36
chr6_53406439_53406590	0.15	GCLC	glutamate-cysteine ligase, catalytic subunit	2892	0.28
chr3_71632244_71632475	0.15	FOXP1	forkhead box P1	545	0.79
chr1_31986580_31986731	0.15	ENSG00000206981	.	16130	0.16
chr11_104940908_104941107	0.15	CARD16	caspase recruitment domain family, member 16	24904	0.15
chr10_7298232_7298383	0.15	SFMBT2	Scm-like with four mbt domains 2	152400	0.04
chr16_11188483_11188858	0.15	RP11-66H6.3		23711	0.16
chr3_5057035_5057190	0.15	BHLHE40-AS1	BHLHE40 antisense RNA 1	35466	0.15
chr4_33186380_33186531	0.15	ENSG00000265035	.	351911	0.01
chr5_61573652_61573803	0.15	KIF2A	kinesin heavy chain member 2A	28262	0.23
chr1_244001324_244001616	0.15	AKT3	v-akt murine thymoma viral oncogene homolog 3	5068	0.28
chr18_43791376_43791983	0.15	C18orf25	chromosome 18 open reading frame 25	37679	0.17
chr6_147525970_147526206	0.15	STXBP5-AS1	STXBP5 antisense RNA 1	338	0.57
chr9_125662422_125663045	0.15	RC3H2	ring finger and CCCH-type domains 2	2344	0.19
chr15_92644884_92645035	0.15	RP11-24J19.1		70707	0.13
chr6_154893428_154893579	0.15	CNKSR3	CNKSR family member 3	61710	0.15
chr9_108462475_108462626	0.14	TMEM38B	transmembrane protein 38B	715	0.75
chr3_56903065_56903308	0.14	ARHGEF3	Rho guanine nucleotide exchange factor (GEF) 3	47313	0.16
chr11_58612469_58612620	0.14	GLYATL2	glycine-N-acyltransferase-like 2	287	0.91
chr12_66690757_66690908	0.14	ENSG00000222744	.	4369	0.19
chr15_70877190_70877341	0.14	UACA	uveal autoantigen with coiled-coil domains and ankyrin repeats	117355	0.06
chr15_43205982_43206133	0.14	TTBK2	tau tubulin kinase 2	5584	0.28
chr1_230415219_230415370	0.14	RP5-956O18.3		2345	0.34
chr14_100689278_100689429	0.14	YY1	YY1 transcription factor	15282	0.11
chr13_107526119_107526366	0.14	ENSG00000239050	.	101132	0.08
chr6_53156340_53156626	0.14	ENSG00000264056	.	14692	0.19
chr13_99857518_99857964	0.14	ENSG00000201793	.	221	0.93
chr3_3232658_3232809	0.14	CRBN	cereblon	11339	0.21
chr1_117313577_117313728	0.14	CD2	CD2 molecule	16563	0.21
chr6_12324816_12324967	0.14	EDN1	endothelin 1	34295	0.22
chr3_23875536_23875687	0.13	UBE2E1	ubiquitin-conjugating enzyme E2E 1	22662	0.17
chr20_40238845_40239072	0.13	CHD6	chromodomain helicase DNA binding protein 6	4454	0.29
chr2_161262836_161263025	0.13	ENSG00000263948	.	1463	0.33
chr7_65196369_65196552	0.13	CCT6P1	chaperonin containing TCP1, subunit 6 (zeta) pseudogene 1	19669	0.15
chr6_119255106_119255516	0.13	MCM9	minichromosome maintenance complex component 9	330	0.7
chr7_78915738_78915889	0.13	ENSG00000212482	.	56875	0.16
chr1_222794325_222794476	0.13	MIA3	melanoma inhibitory activity family, member 3	2950	0.22
chr17_48501050_48501201	0.13	ACSF2	acyl-CoA synthetase family member 2	2394	0.17
chr18_21406136_21407050	0.13	LAMA3	laminin, alpha 3	7324	0.26
chr15_91143361_91143512	0.13	CTD-3065B20.2		3757	0.19
chr22_23218111_23218262	0.13	IGLV3-2	immunoglobulin lambda variable 3-2 (pseudogene)	2795	0.07
chr7_150300875_150301266	0.13	GIMAP6	GTPase, IMAP family member 6	28364	0.15
chr6_26189961_26190186	0.13	HIST1H4D	histone cluster 1, H4d	769	0.33
chr17_66181792_66181975	0.13	LRRC37A16P	leucine rich repeat containing 37, member A16, pseudogene	33274	0.14
chr6_139612233_139612724	0.13	TXLNB	taxilin beta	798	0.66
chr16_89425528_89425713	0.13	ANKRD11	ankyrin repeat domain 11	30226	0.11
chr7_56101315_56101548	0.13	PSPH	phosphoserine phosphatase	418	0.75
chrX_119588396_119588571	0.13	LAMP2	lysosomal-associated membrane protein 2	14364	0.22
chr10_73059409_73059560	0.13	SLC29A3	solute carrier family 29 (equilibrative nucleoside transporter), member 3	19531	0.18
chr10_86094464_86094669	0.13	CCSER2	coiled-coil serine-rich protein 2	6147	0.27
chr8_120219756_120219907	0.13	MAL2	mal, T-cell differentiation protein 2 (gene/pseudogene)	779	0.76
chr4_109352208_109352359	0.13	ENSG00000266046	.	146013	0.04
chr6_6386672_6386823	0.13	F13A1	coagulation factor XIII, A1 polypeptide	65501	0.13
chr1_184081330_184081481	0.13	ENSG00000199840	.	59552	0.12
chr5_123395807_123395958	0.13	CSNK1G3	casein kinase 1, gamma 3	471763	0.01
chr6_2127389_2127540	0.13	GMDS	GDP-mannose 4,6-dehydratase	48761	0.2
chr3_50662504_50662845	0.13	MAPKAPK3	mitogen-activated protein kinase-activated protein kinase 3	7853	0.15
chr1_247489619_247489770	0.13	ZNF496	zinc finger protein 496	2853	0.26
chr6_25405524_25405816	0.13	ENSG00000253017	.	2453	0.28
chr14_50317979_50318647	0.13	NEMF	nuclear export mediator factor	1185	0.29
chr2_54818302_54818646	0.13	SPTBN1	spectrin, beta, non-erythrocytic 1	32943	0.15
chr12_8101245_8101532	0.13	SLC2A3	solute carrier family 2 (facilitated glucose transporter), member 3	12517	0.15
chr7_2920385_2920536	0.13	GNA12	guanine nucleotide binding protein (G protein) alpha 12	36502	0.16
chr3_142682236_142682387	0.13	PAQR9	progestin and adipoQ receptor family member IX	133	0.82
chr1_67575967_67576118	0.13	ENSG00000252433	.	7580	0.18
chrX_78412182_78412333	0.13	GPR174	G protein-coupled receptor 174	14212	0.31
chr20_36667703_36667854	0.13	RPRD1B	regulation of nuclear pre-mRNA domain containing 1B	5830	0.17
chrX_119592645_119592909	0.12	LAMP2	lysosomal-associated membrane protein 2	10070	0.23
chr9_38070649_38070800	0.12	SHB	Src homology 2 domain containing adaptor protein B	1514	0.5
chr15_66750716_66750867	0.12	MAP2K1	mitogen-activated protein kinase kinase 1	4999	0.11
chr16_76699686_76699837	0.12	RP11-58C22.1	Uncharacterized protein	112447	0.07
chr1_232929880_232930031	0.12	MAP10	microtubule-associated protein 10	10688	0.25
chr13_29101657_29101953	0.12	FLT1	fms-related tyrosine kinase 1	32540	0.22
chr19_16571262_16571413	0.12	EPS15L1	epidermal growth factor receptor pathway substrate 15-like 1	11417	0.12
chr6_88541623_88541774	0.12	ENSG00000207131	.	5695	0.2
chr6_25442292_25442443	0.12	ENSG00000238322	.	6859	0.22
chr2_122405151_122406002	0.12	CLASP1	cytoplasmic linker associated protein 1	1476	0.32
chrX_70585571_70585723	0.12	TAF1	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa	467	0.83
chr2_26017998_26018199	0.12	ASXL2	additional sex combs like 2 (Drosophila)	14920	0.24
chr9_120588985_120589386	0.12	ENSG00000251847	.	95436	0.08
chr6_15400503_15400654	0.12	JARID2	jumonji, AT rich interactive domain 2	511	0.85
chr6_118570742_118570893	0.12	PLN	phospholamban	298644	0.01
chr9_93626346_93626497	0.12	SYK	spleen tyrosine kinase	36651	0.24
chr19_12844114_12844270	0.12	C19orf43	chromosome 19 open reading frame 43	1288	0.2
chr9_92108756_92109116	0.12	SEMA4D	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D	3411	0.27
chr12_21832380_21832693	0.12	RP11-59N23.3		17289	0.18
chr1_198146103_198146254	0.12	NEK7	NIMA-related kinase 7	19927	0.29
chr9_3523924_3524075	0.12	RFX3	regulatory factor X, 3 (influences HLA class II expression)	1984	0.45
chr12_89763940_89764091	0.12	DUSP6	dual specificity phosphatase 6	16967	0.24
chr14_91863332_91863575	0.12	CCDC88C	coiled-coil domain containing 88C	20237	0.21
chr11_35822778_35822929	0.12	RP11-698N11.4		13029	0.23
chr19_2608004_2608206	0.12	CTC-265F19.2		3755	0.18
chr10_43898812_43898963	0.12	HNRNPF	heterogeneous nuclear ribonucleoprotein F	4380	0.18
chr15_96539880_96540048	0.12	NR2F2-AS1	NR2F2 antisense RNA 1	226320	0.02
chrX_12979344_12979749	0.12	TMSB4X	thymosin beta 4, X-linked	13681	0.21
chr2_103289356_103289507	0.12	SLC9A2	solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2	53265	0.13
chr3_51597694_51597897	0.12	RAD54L2	RAD54-like 2 (S. cerevisiae)	22199	0.17
chr14_55035050_55035201	0.12	SAMD4A	sterile alpha motif domain containing 4A	488	0.84
chr4_153354722_153354873	0.12	FBXW7	F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase	21039	0.21
chr4_55685762_55685928	0.12	KIT	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	161760	0.04
chr3_166163700_166163851	0.12	ENSG00000251759	.	224135	0.02
chrX_54442885_54443036	0.12	TSR2	TSR2, 20S rRNA accumulation, homolog (S. cerevisiae)	23874	0.19
chr10_126234282_126234537	0.12	LHPP	phospholysine phosphohistidine inorganic pyrophosphate phosphatase	83997	0.08
chr1_144084731_144084882	0.12	NBPF8	neuroblastoma breakpoint family, member 8	62002	0.13
chr3_45005575_45005726	0.12	ZDHHC3	zinc finger, DHHC-type containing 3	12008	0.15
chr12_7906549_7906700	0.12	CLEC4C	C-type lectin domain family 4, member C	2423	0.19
chr4_71572054_71572676	0.11	RUFY3	RUN and FYVE domain containing 3	1847	0.19
chr7_80547947_80548212	0.11	SEMA3C	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C	420	0.92
chr5_122885697_122885899	0.11	CSNK1G3	casein kinase 1, gamma 3	4470	0.3
chr21_19162869_19163124	0.11	AL109761.5		2809	0.31
chr7_143333727_143333976	0.11	FAM115C	family with sequence similarity 115, member C	15306	0.19
chr1_111762611_111763176	0.11	CHI3L2	chitinase 3-like 2	6745	0.14
chr2_65390128_65390454	0.11	ENSG00000272025	.	4495	0.24
chr1_68101529_68101856	0.11	ENSG00000242482	.	21120	0.21
chr16_17468478_17468629	0.11	XYLT1	xylosyltransferase I	96185	0.09
chr10_12110496_12110658	0.11	DHTKD1	dehydrogenase E1 and transketolase domain containing 1	394	0.83
chr6_16162236_16162478	0.11	ENSG00000251793	.	13681	0.16
chr1_67636156_67636590	0.11	IL23R	interleukin 23 receptor	4204	0.2
chr15_64105699_64105850	0.11	HERC1	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1	20310	0.21
chr8_79423337_79423629	0.11	PKIA	protein kinase (cAMP-dependent, catalytic) inhibitor alpha	4891	0.32
chr6_108686448_108686599	0.11	ENSG00000200799	.	26754	0.18
chr16_12174266_12174426	0.11	RP11-276H1.3		9813	0.16
chr7_138309701_138309924	0.11	ENSG00000252188	.	112	0.97
chrX_47411122_47411273	0.11	ARAF	v-raf murine sarcoma 3611 viral oncogene homolog	9319	0.15
chr6_34906018_34906169	0.11	ANKS1A	ankyrin repeat and sterile alpha motif domain containing 1A	49013	0.13
chr22_40783696_40783896	0.11	RP5-1042K10.10		425	0.81
chr1_93971516_93971910	0.11	ENSG00000212601	.	17704	0.18
chr13_73144148_73144299	0.11	ENSG00000199282	.	16595	0.24
chr16_28146383_28146648	0.11	XPO6	exportin 6	23304	0.17
chr4_22515546_22516022	0.11	GPR125	G protein-coupled receptor 125	1836	0.52
chr10_74578727_74578925	0.11	RP11-354E23.5		52508	0.12

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of ONECUT2_ONECUT3

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0035426	extracellular matrix-cell signaling(GO:0035426)
0.1	0.2	GO:0001778	plasma membrane repair(GO:0001778)
0.0	0.1	GO:0002323	natural killer cell activation involved in immune response(GO:0002323) natural killer cell degranulation(GO:0043320)
0.0	0.2	GO:0051570	regulation of histone H3-K9 methylation(GO:0051570)
0.0	0.1	GO:0003215	cardiac right ventricle morphogenesis(GO:0003215)
0.0	0.2	GO:0007256	activation of JNKK activity(GO:0007256)
0.0	0.1	GO:0010761	fibroblast migration(GO:0010761)
0.0	0.1	GO:0016576	histone dephosphorylation(GO:0016576)
0.0	0.1	GO:0002329	immature B cell differentiation(GO:0002327) pre-B cell differentiation(GO:0002329)
0.0	0.1	GO:0070340	detection of bacterial lipoprotein(GO:0042494) detection of bacterial lipopeptide(GO:0070340)
0.0	0.1	GO:0036037	CD8-positive, alpha-beta T cell activation(GO:0036037) CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0	0.1	GO:0006564	L-serine biosynthetic process(GO:0006564)
0.0	0.1	GO:0001911	negative regulation of leukocyte mediated cytotoxicity(GO:0001911)
0.0	0.1	GO:0019731	antibacterial humoral response(GO:0019731)
0.0	0.1	GO:0035405	histone-threonine phosphorylation(GO:0035405)
0.0	0.1	GO:0003323	type B pancreatic cell development(GO:0003323)
0.0	0.1	GO:0060261	positive regulation of transcription initiation from RNA polymerase II promoter(GO:0060261) positive regulation of DNA-templated transcription, initiation(GO:2000144)
0.0	0.1	GO:0032823	regulation of natural killer cell differentiation(GO:0032823) positive regulation of natural killer cell differentiation(GO:0032825)
0.0	0.1	GO:0061154	endothelial tube morphogenesis(GO:0061154)
0.0	0.1	GO:0044256	multicellular organismal protein catabolic process(GO:0044254) protein digestion(GO:0044256) multicellular organismal macromolecule catabolic process(GO:0044266) multicellular organismal protein metabolic process(GO:0044268)
0.0	0.1	GO:0003056	regulation of vascular smooth muscle contraction(GO:0003056)
0.0	0.0	GO:0042520	tyrosine phosphorylation of Stat4 protein(GO:0042504) regulation of tyrosine phosphorylation of Stat4 protein(GO:0042519) positive regulation of tyrosine phosphorylation of Stat4 protein(GO:0042520)
0.0	0.1	GO:0006491	N-glycan processing(GO:0006491)
0.0	0.1	GO:0016584	nucleosome positioning(GO:0016584)
0.0	0.1	GO:0019987	obsolete negative regulation of anti-apoptosis(GO:0019987)
0.0	0.0	GO:0060585	regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
0.0	0.0	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II(GO:0019886)
0.0	0.0	GO:0002495	antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.0	0.0	GO:0046643	regulation of gamma-delta T cell differentiation(GO:0045586) positive regulation of gamma-delta T cell differentiation(GO:0045588) regulation of gamma-delta T cell activation(GO:0046643) positive regulation of gamma-delta T cell activation(GO:0046645)
0.0	0.1	GO:0051409	response to nitrosative stress(GO:0051409)
0.0	0.1	GO:0072131	kidney mesenchyme morphogenesis(GO:0072131) metanephric mesenchyme morphogenesis(GO:0072133)
0.0	0.0	GO:0006189	'de novo' IMP biosynthetic process(GO:0006189)
0.0	0.1	GO:0002903	negative regulation of B cell apoptotic process(GO:0002903)
0.0	0.0	GO:0071569	protein ufmylation(GO:0071569)
0.0	0.0	GO:0048388	endosomal lumen acidification(GO:0048388)
0.0	0.1	GO:0001553	luteinization(GO:0001553)
0.0	0.0	GO:0006667	sphinganine metabolic process(GO:0006667)
0.0	0.0	GO:0002313	mature B cell differentiation involved in immune response(GO:0002313)
0.0	0.0	GO:0070634	transepithelial ammonium transport(GO:0070634)
0.0	0.0	GO:0006434	seryl-tRNA aminoacylation(GO:0006434)
0.0	0.0	GO:0018206	peptidyl-methionine modification(GO:0018206)
0.0	0.0	GO:0000491	small nucleolar ribonucleoprotein complex assembly(GO:0000491) box C/D snoRNP assembly(GO:0000492)
0.0	0.1	GO:0010887	negative regulation of cholesterol storage(GO:0010887)
0.0	0.1	GO:0000729	DNA double-strand break processing(GO:0000729)
0.0	0.0	GO:0007571	age-dependent response to oxidative stress(GO:0001306) age-dependent general metabolic decline(GO:0007571)
0.0	0.1	GO:0031529	ruffle organization(GO:0031529)
0.0	0.1	GO:0006610	ribosomal protein import into nucleus(GO:0006610)
0.0	0.1	GO:0002860	natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002420) natural killer cell mediated immune response to tumor cell(GO:0002423) regulation of natural killer cell mediated immune response to tumor cell(GO:0002855) positive regulation of natural killer cell mediated immune response to tumor cell(GO:0002857) regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002858) positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002860)
0.0	0.1	GO:0055075	potassium ion homeostasis(GO:0055075)
0.0	0.0	GO:0001955	blood vessel maturation(GO:0001955)
0.0	0.0	GO:0006172	ADP biosynthetic process(GO:0006172) purine nucleoside diphosphate biosynthetic process(GO:0009136) purine ribonucleoside diphosphate biosynthetic process(GO:0009180) ribonucleoside diphosphate biosynthetic process(GO:0009188)
0.0	0.0	GO:0010956	negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137)
0.0	0.0	GO:0001821	histamine secretion(GO:0001821)
0.0	0.1	GO:0001561	fatty acid alpha-oxidation(GO:0001561)
0.0	0.1	GO:0010507	negative regulation of autophagy(GO:0010507)

Gene overrepresentation in cellular component category:

Total log-likelihood	Term	Description
0.1	GO:0031088	platelet dense granule membrane(GO:0031088)
0.2	GO:0005665	DNA-directed RNA polymerase II, core complex(GO:0005665)
0.1	GO:0031932	TORC2 complex(GO:0031932)
0.2	GO:0035098	ESC/E(Z) complex(GO:0035098)
0.2	GO:0030670	phagocytic vesicle membrane(GO:0030670)
0.1	GO:0048786	presynaptic active zone(GO:0048786)
0.0	GO:0031904	endosome lumen(GO:0031904)
0.0	GO:0071664	catenin-TCF7L2 complex(GO:0071664)
0.1	GO:0031371	ubiquitin conjugating enzyme complex(GO:0031371)
0.1	GO:0001891	phagocytic cup(GO:0001891)
0.0	GO:0002139	stereocilia coupling link(GO:0002139) stereocilia ankle link(GO:0002141) stereocilia ankle link complex(GO:0002142)
0.1	GO:0031080	nuclear pore outer ring(GO:0031080)
0.0	GO:0005896	interleukin-6 receptor complex(GO:0005896)
0.0	GO:0098984	asymmetric synapse(GO:0032279) neuron to neuron synapse(GO:0098984)
0.0	GO:0000300	obsolete peripheral to membrane of membrane fraction(GO:0000300)
0.0	GO:0071942	XPC complex(GO:0071942)
0.1	GO:0090533	cation-transporting ATPase complex(GO:0090533)
0.1	GO:0072357	PTW/PP1 phosphatase complex(GO:0072357)
0.1	GO:0044224	juxtaparanode region of axon(GO:0044224)
0.0	GO:0032444	activin responsive factor complex(GO:0032444)
0.0	GO:0038201	TORC1 complex(GO:0031931) TOR complex(GO:0038201)
0.0	GO:0005947	mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947)

Gene overrepresentation in molecular function category:

Total log-likelihood	Term	Description
0.1	GO:0030375	thyroid hormone receptor coactivator activity(GO:0030375)
0.1	GO:0030215	semaphorin receptor binding(GO:0030215)
0.1	GO:0047961	glycine N-acyltransferase activity(GO:0047961)
0.1	GO:0004591	oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.2	GO:0043237	laminin-1 binding(GO:0043237)
0.1	GO:0008454	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.4	GO:0004697	protein kinase C activity(GO:0004697)
0.1	GO:0004013	adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.1	GO:0048027	mRNA 5'-UTR binding(GO:0048027)
0.2	GO:0032452	histone demethylase activity(GO:0032452)
0.1	GO:0008900	hydrogen:potassium-exchanging ATPase activity(GO:0008900)
0.1	GO:0070577	lysine-acetylated histone binding(GO:0070577)
0.1	GO:0005094	Rho GDP-dissociation inhibitor activity(GO:0005094)
0.1	GO:0008241	peptidyl-dipeptidase activity(GO:0008241)
0.1	GO:0043515	kinetochore binding(GO:0043515)
0.1	GO:0008545	JUN kinase kinase activity(GO:0008545)
0.1	GO:0004470	malic enzyme activity(GO:0004470)
0.1	GO:0034186	apolipoprotein A-I binding(GO:0034186)
0.0	GO:0071723	lipopeptide binding(GO:0071723)
0.1	GO:0008474	palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.1	GO:0030371	translation repressor activity(GO:0030371)
0.2	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.1	GO:0043422	protein kinase B binding(GO:0043422)
0.1	GO:0031491	nucleosome binding(GO:0031491)
0.0	GO:0043142	single-stranded DNA-dependent ATPase activity(GO:0043142)
0.0	GO:0031705	bombesin receptor binding(GO:0031705) endothelin B receptor binding(GO:0031708)
0.1	GO:0051637	obsolete Gram-positive bacterial cell surface binding(GO:0051637)
0.0	GO:0004828	serine-tRNA ligase activity(GO:0004828)
0.0	GO:0004677	DNA-dependent protein kinase activity(GO:0004677)
0.1	GO:0001786	phosphatidylserine binding(GO:0001786)
0.0	GO:0008321	Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0	GO:0005148	prolactin receptor binding(GO:0005148)
0.1	GO:0005087	Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.1	GO:0008266	poly(U) RNA binding(GO:0008266)
0.1	GO:0001671	ATPase activator activity(GO:0001671)
0.0	GO:0004505	phenylalanine 4-monooxygenase activity(GO:0004505)
0.0	GO:0004758	serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0	GO:0017112	Rab guanyl-nucleotide exchange factor activity(GO:0017112)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.2	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.2	REACTOME VIRAL MESSENGER RNA SYNTHESIS	Genes involved in Viral Messenger RNA Synthesis
0.3	REACTOME EFFECTS OF PIP2 HYDROLYSIS	Genes involved in Effects of PIP2 hydrolysis
0.1	REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION	Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.1	REACTOME ELONGATION ARREST AND RECOVERY	Genes involved in Elongation arrest and recovery