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ENCODE: H3K4me1 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4

Z-value: 1.13

Motif logo

Transcription factors associated with OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4

Gene Symbol	Gene ID	Gene Info
OTP Ensembl NCBI GeneCards UniProt	ENSG00000171540.6	OTP
PHOX2B Ensembl NCBI GeneCards UniProt	ENSG00000109132.5	PHOX2B
LHX1 Ensembl NCBI GeneCards UniProt	ENSG00000132130.7	LHX1
LMX1A Ensembl NCBI GeneCards UniProt	ENSG00000162761.10	LMX1A
LHX5 Ensembl NCBI GeneCards UniProt	ENSG00000089116.3	LHX5
HOXC4 Ensembl NCBI GeneCards UniProt	ENSG00000198353.6	HOXC4
HOXC4 Ensembl NCBI GeneCards UniProt	ENSG00000273266.1	HOXC4

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
HOXC4	chr12_54445565_54445716	2021	0.150444	-0.80	9.3e-03	Click!
HOXC4	chr12_54446583_54446734	1003	0.313930	-0.70	3.5e-02	Click!
HOXC4	chr12_54444274_54444437	3306	0.105420	-0.55	1.3e-01	Click!
HOXC4	chr12_54440337_54440488	7249	0.079527	-0.43	2.5e-01	Click!
HOXC4	chr12_54448397_54448560	817	0.393761	-0.42	2.6e-01	Click!
LHX1	chr17_35296063_35296214	2054	0.201057	-0.34	3.7e-01	Click!
LHX1	chr17_35296673_35296888	2696	0.169610	-0.23	5.5e-01	Click!
LHX1	chr17_35297073_35297224	3064	0.157991	-0.21	5.8e-01	Click!
LHX1	chr17_35294366_35294638	418	0.527790	-0.16	6.8e-01	Click!
LHX1	chr17_35295255_35295907	1497	0.251885	-0.15	7.0e-01	Click!
LHX5	chr12_113911961_113912112	2159	0.249682	-0.76	1.8e-02	Click!
LHX5	chr12_113917208_113917359	7406	0.177994	0.49	1.8e-01	Click!
LHX5	chr12_113917522_113917673	7720	0.177321	0.40	2.9e-01	Click!
LHX5	chr12_113917030_113917181	7228	0.178411	0.34	3.7e-01	Click!
LHX5	chr12_113912283_113912434	2481	0.233588	-0.29	4.6e-01	Click!
LMX1A	chr1_165362912_165363063	37035	0.169020	-0.74	2.2e-02	Click!
LMX1A	chr1_165345045_165345196	19168	0.227140	-0.70	3.7e-02	Click!
LMX1A	chr1_165323663_165323814	1245	0.570752	-0.58	9.9e-02	Click!
LMX1A	chr1_165340840_165340991	14963	0.239522	0.54	1.3e-01	Click!
LMX1A	chr1_165362227_165362585	36454	0.170928	0.48	1.9e-01	Click!
OTP	chr5_76967801_76967952	32363	0.180175	0.62	7.3e-02	Click!
OTP	chr5_76965672_76965823	30234	0.186092	0.61	8.3e-02	Click!
OTP	chr5_76936180_76936340	747	0.721696	0.58	1.0e-01	Click!
OTP	chr5_76935013_76935235	389	0.888187	0.53	1.5e-01	Click!
OTP	chr5_76936547_76936706	1113	0.575408	0.47	2.0e-01	Click!
PHOX2B	chr4_41749678_41749829	29	0.914159	0.55	1.2e-01	Click!
PHOX2B	chr4_41753651_41753802	2739	0.239918	0.48	1.9e-01	Click!
PHOX2B	chr4_41748485_41748636	1164	0.410771	-0.26	5.0e-01	Click!
PHOX2B	chr4_41748277_41748428	1372	0.365894	0.21	5.9e-01	Click!
PHOX2B	chr4_41749406_41749557	243	0.836111	0.10	8.0e-01	Click!

Activity of the OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4 motif across conditions

Conditions sorted by the z-value of the OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr9_90215657_90216062	0.96	DAPK1-IT1	DAPK1 intronic transcript 1 (non-protein coding)	47490	0.16
chr3_60994387_60994642	0.74	ENSG00000212211	.	152237	0.05
chr2_160789612_160789827	0.73	LY75-CD302	LY75-CD302 readthrough	28498	0.19
chr11_122897468_122897619	0.70	ENSG00000200879	.	31326	0.12
chr12_63292090_63292337	0.69	PPM1H	protein phosphatase, Mg2+/Mn2+ dependent, 1H	36604	0.16
chr6_154629838_154630022	0.68	IPCEF1	interaction protein for cytohesin exchange factors 1	21285	0.27
chr7_87943895_87944046	0.68	STEAP4	STEAP family member 4	7764	0.24
chr17_72687300_72687451	0.67	CTD-2006K23.2		13636	0.11
chr2_8007405_8007668	0.66	ENSG00000221255	.	290564	0.01
chr19_51642136_51642312	0.65	SIGLEC7	sialic acid binding Ig-like lectin 7	3332	0.11
chr10_129077210_129077361	0.65	FAM196A	family with sequence similarity 196, member A	82863	0.11
chr20_20760824_20761172	0.64	ENSG00000264361	.	41624	0.19
chr13_72218273_72218424	0.63	DACH1	dachshund homolog 1 (Drosophila)	222559	0.02
chr18_24291515_24291666	0.63	ENSG00000265369	.	22097	0.21
chr15_70556363_70556608	0.62	ENSG00000200216	.	70910	0.13
chr3_187492287_187492506	0.61	BCL6	B-cell CLL/lymphoma 6	28881	0.2
chr20_3634350_3634501	0.60	GFRA4	GDNF family receptor alpha 4	9621	0.17
chr15_58440694_58440845	0.60	ALDH1A2	aldehyde dehydrogenase 1 family, member A2	9745	0.23
chr6_2873810_2873961	0.59	ENSG00000266750	.	19544	0.15
chr14_56703934_56704085	0.58	PELI2	pellino E3 ubiquitin protein ligase family member 2	118182	0.06
chr12_8309941_8310303	0.58	ZNF705A	zinc finger protein 705A	492	0.74
chr4_22347334_22347485	0.58	ENSG00000238383	.	3664	0.37
chr5_142808848_142808999	0.57	NR3C1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	5344	0.32
chr2_240358593_240358744	0.57	AC062017.1	Uncharacterized protein	35169	0.16
chr3_150609075_150609226	0.57	FAM188B2	family with sequence similarity 188, member B2	303	0.75
chr5_40258873_40259248	0.57	ENSG00000199361	.	10600	0.28
chr13_49475290_49475441	0.56	ENSG00000265585	.	28983	0.2
chr12_20433368_20433519	0.56	PDE3A	phosphodiesterase 3A, cGMP-inhibited	88736	0.09
chr7_8290002_8290153	0.54	ICA1	islet cell autoantigen 1, 69kDa	11605	0.18
chr4_102157713_102157864	0.54	ENSG00000221265	.	93783	0.08
chr3_187491464_187491692	0.54	BCL6	B-cell CLL/lymphoma 6	28063	0.2
chrX_78056073_78056224	0.53	LPAR4	lysophosphatidic acid receptor 4	52920	0.17
chr5_10543561_10543712	0.53	ANKRD33B	ankyrin repeat domain 33B	20944	0.17
chr12_109060942_109061130	0.53	ENSG00000238457	.	1188	0.4
chr14_101309389_101309643	0.53	ENSG00000214548	.	6129	0.04
chr5_153677525_153677842	0.53	ENSG00000221070	.	42003	0.14
chr4_175535548_175535713	0.52	HPGD	hydroxyprostaglandin dehydrogenase 15-(NAD)	91325	0.09
chr22_36846800_36846951	0.51	ENSG00000252225	.	9860	0.15
chr4_91259651_91259802	0.51	ENSG00000252087	.	31548	0.24
chr2_28826366_28826777	0.51	PLB1	phospholipase B1	1785	0.41
chr7_129266806_129267096	0.50	NRF1	nuclear respiratory factor 1	2958	0.32
chr16_23935796_23935947	0.50	PRKCB	protein kinase C, beta	87327	0.09
chr1_83043773_83044235	0.50	LPHN2	latrophilin 2	598431	0.0
chr6_45708783_45708953	0.50	ENSG00000252738	.	95027	0.09
chr16_48202293_48202444	0.49	RP11-3M1.1		1219	0.5
chr8_98611233_98611384	0.49	MTDH	metadherin	45099	0.18
chr12_80333289_80333440	0.49	PPP1R12A	protein phosphatase 1, regulatory subunit 12A	4124	0.23
chr3_48800674_48800825	0.49	PRKAR2A	protein kinase, cAMP-dependent, regulatory, type II, alpha	2034	0.27
chr5_40608102_40608403	0.48	ENSG00000199552	.	46813	0.16
chr6_139911017_139911168	0.48	CITED2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	215335	0.02
chr20_39556054_39556329	0.48	ENSG00000238908	.	73322	0.11
chr5_58473985_58474185	0.48	PDE4D	phosphodiesterase 4D, cAMP-specific	97860	0.09
chr12_89549700_89550075	0.48	ENSG00000238302	.	126175	0.06
chr7_26143414_26143565	0.48	ENSG00000266430	.	43530	0.14
chr5_124214579_124214730	0.48	ZNF608	zinc finger protein 608	130154	0.05
chr5_131042623_131042844	0.47	RAPGEF6	Rap guanine nucleotide exchange factor (GEF) 6	71804	0.1
chr17_43640517_43640668	0.47	RP11-798G7.4		4156	0.16
chr4_15662221_15662454	0.47	FBXL5	F-box and leucine-rich repeat protein 5	847	0.63
chr7_37726411_37726562	0.47	GPR141	G protein-coupled receptor 141	3011	0.28
chr18_10265882_10266063	0.47	ENSG00000239031	.	124025	0.06
chr2_86833071_86833228	0.47	AC015971.2		1736	0.29
chr10_115625916_115626067	0.47	NHLRC2	NHL repeat containing 2	11571	0.17
chr12_72239825_72240258	0.47	TBC1D15	TBC1 domain family, member 15	6483	0.27
chr3_30234621_30234879	0.46	ENSG00000266546	.	54226	0.15
chr3_158177960_158178111	0.46	RP11-538P18.2		110661	0.06
chr1_110426574_110426869	0.46	RP11-195M16.1		2165	0.29
chr3_158546491_158546642	0.46	MFSD1	major facilitator superfamily domain containing 1	19540	0.17
chr4_159636625_159636776	0.46	PPID	peptidylprolyl isomerase D	4727	0.19
chr4_11475647_11475798	0.46	HS3ST1	heparan sulfate (glucosamine) 3-O-sulfotransferase 1	44333	0.18
chr3_167577259_167577557	0.45	SERPINI1	serpin peptidase inhibitor, clade I (neuroserpin), member 1	52382	0.17
chr9_83728858_83729320	0.45	ENSG00000221581	.	379845	0.01
chr13_99930486_99930694	0.45	GPR18	G protein-coupled receptor 18	16592	0.18
chr11_122263808_122263959	0.45	ENSG00000252776	.	56035	0.13
chr3_32885003_32885154	0.45	TRIM71	tripartite motif containing 71, E3 ubiquitin protein ligase	25568	0.22
chr12_46049044_46049290	0.45	ARID2	AT rich interactive domain 2 (ARID, RFX-like)	74281	0.12
chr9_114604147_114604298	0.45	ENSG00000206907	.	2114	0.34
chr20_48843302_48843512	0.45	CEBPB	CCAAT/enhancer binding protein (C/EBP), beta	36031	0.16
chr17_4158247_4158398	0.44	ANKFY1	ankyrin repeat and FYVE domain containing 1	8820	0.18
chr12_6950808_6951107	0.44	GNB3	guanine nucleotide binding protein (G protein), beta polypeptide 3	507	0.54
chr21_36474427_36475070	0.44	RUNX1	runt-related transcription factor 1	53107	0.18
chr13_41900270_41900421	0.44	NAA16	N(alpha)-acetyltransferase 16, NatA auxiliary subunit	14929	0.18
chr4_86581051_86581326	0.44	ARHGAP24	Rho GTPase activating protein 24	55882	0.15
chr9_92142486_92142637	0.44	SEMA4D	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D	29516	0.19
chr1_198955554_198955705	0.44	ENSG00000207759	.	127347	0.06
chr6_13295327_13295514	0.44	RP1-257A7.4		398	0.86
chr17_35567851_35568148	0.44	ACACA	acetyl-CoA carboxylase alpha	5273	0.28
chr6_99465727_99465878	0.44	FBXL4	F-box and leucine-rich repeat protein 4	69953	0.12
chr2_145184442_145184602	0.44	ZEB2	zinc finger E-box binding homeobox 2	3071	0.37
chr6_46758113_46758264	0.44	MEP1A	meprin A, alpha (PABA peptide hydrolase)	2939	0.26
chr4_74945123_74945274	0.43	CXCL2	chemokine (C-X-C motif) ligand 2	19812	0.13
chr1_184123472_184123623	0.43	ENSG00000199840	.	17410	0.25
chr4_42685625_42685776	0.43	RP11-109E24.2		26187	0.21
chr17_75955777_75956008	0.43	ENSG00000238898	.	39712	0.14
chr10_105762563_105762714	0.43	ENSG00000266754	.	28066	0.13
chr3_151064370_151064574	0.43	P2RY13	purinergic receptor P2Y, G-protein coupled, 13	17136	0.16
chr2_7568466_7568701	0.43	ENSG00000221255	.	148389	0.05
chr11_121320555_121321108	0.43	SORL1	sortilin-related receptor, L(DLR class) A repeats containing	2081	0.35
chr14_70110903_70111120	0.43	KIAA0247	KIAA0247	32698	0.18
chr14_103586056_103586207	0.43	TNFAIP2	tumor necrosis factor, alpha-induced protein 2	3667	0.2
chr22_26968968_26969143	0.43	TPST2	tyrosylprotein sulfotransferase 2	7363	0.16
chr14_103106612_103106763	0.43	RCOR1	REST corepressor 1	47454	0.12
chr8_60239607_60239866	0.42	ENSG00000201763	.	128708	0.06
chr11_15663702_15663853	0.42	ENSG00000253072	.	160338	0.04
chr2_33309027_33309178	0.42	LTBP1	latent transforming growth factor beta binding protein 1	50371	0.16
chr9_113643265_113643416	0.42	ENSG00000206923	.	22277	0.22
chr8_29057628_29057779	0.42	ENSG00000264328	.	57493	0.09
chr1_245120739_245120890	0.42	ENSG00000252073	.	2654	0.2
chr9_37340860_37341011	0.41	ENSG00000206784	.	18679	0.19
chr12_104200199_104200350	0.41	RP11-650K20.2		13114	0.14
chr12_58334098_58334402	0.41	XRCC6BP1	XRCC6 binding protein 1	1110	0.49
chr9_129117832_129118014	0.41	MVB12B	multivesicular body subunit 12B	20397	0.22
chr20_6888062_6888352	0.41	ENSG00000251833	.	46546	0.2
chr9_113036102_113036253	0.41	TXN	thioredoxin	17257	0.22
chr1_21464907_21465058	0.41	EIF4G3	eukaryotic translation initiation factor 4 gamma, 3	36248	0.16
chr9_129253120_129253632	0.41	ENSG00000221768	.	39894	0.15
chr4_38771269_38771420	0.41	TLR10	toll-like receptor 10	6473	0.17
chr14_77873001_77873391	0.41	FKSG61		9545	0.11
chr11_33914194_33914345	0.41	LMO2	LIM domain only 2 (rhombotin-like 1)	433	0.85
chr4_102209426_102209650	0.41	ENSG00000221265	.	42033	0.16
chr5_58648581_58648732	0.41	PDE4D	phosphodiesterase 4D, cAMP-specific	4145	0.37
chr16_50720309_50720716	0.41	SNX20	sorting nexin 20	5248	0.13
chr11_113981742_113981893	0.40	ENSG00000221112	.	24166	0.2
chr3_52222826_52222980	0.40	ALAS1	aminolevulinate, delta-, synthase 1	9199	0.12
chr17_28201777_28201939	0.40	ENSG00000239129	.	8166	0.15
chr13_32715851_32716002	0.40	FRY	furry homolog (Drosophila)	80925	0.1
chr6_51167339_51167725	0.40	ENSG00000212532	.	161956	0.04
chr2_64885350_64885511	0.40	SERTAD2	SERTA domain containing 2	4383	0.28
chr14_90243307_90243458	0.40	ENSG00000200312	.	64527	0.12
chr2_136672238_136672389	0.40	DARS	aspartyl-tRNA synthetase	5810	0.22
chr10_119190897_119191141	0.40	EMX2OS	EMX2 opposite strand/antisense RNA	45665	0.14
chr9_38163832_38163983	0.40	ENSG00000200026	.	16482	0.22
chr7_40800196_40800347	0.40	AC005160.3		14886	0.31
chr6_110958471_110958622	0.39	CDK19	cyclin-dependent kinase 19	5975	0.27
chr17_28275117_28275440	0.39	EFCAB5	EF-hand calcium binding domain 5	6655	0.17
chr1_108426463_108426732	0.39	VAV3-AS1	VAV3 antisense RNA 1	80468	0.09
chr3_65923208_65923420	0.39	ENSG00000264716	.	3608	0.24
chr22_27836384_27836535	0.39	RP11-375H17.1		276009	0.01
chr1_115630756_115631224	0.39	TSPAN2	tetraspanin 2	1045	0.64
chr2_60326016_60326167	0.39	ENSG00000200807	.	285649	0.01
chr5_14464778_14464932	0.39	TRIO	trio Rho guanine nucleotide exchange factor	23702	0.26
chr12_2452782_2452951	0.39	CACNA1C-IT3	CACNA1C intronic transcript 3 (non-protein coding)	73924	0.11
chr11_17186256_17186419	0.39	PIK3C2A	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha	4951	0.19
chr1_100293238_100293389	0.39	ENSG00000252226	.	1708	0.32
chr1_239979030_239979181	0.39	CHRM3-AS1	CHRM3 antisense RNA 1	84067	0.09
chr4_26727880_26728031	0.38	ENSG00000200999	.	24024	0.23
chrX_19703551_19703723	0.38	SH3KBP1	SH3-domain kinase binding protein 1	14521	0.29
chr5_83327765_83327916	0.38	ENSG00000216125	.	58135	0.16
chr8_68304495_68304646	0.38	ARFGEF1	ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)	48658	0.18
chr1_162224806_162225003	0.38	RP11-565P22.2		62680	0.09
chr12_57095198_57095389	0.38	PTGES3	prostaglandin E synthase 3 (cytosolic)	13134	0.11
chr2_88297178_88297329	0.38	RGPD2	RANBP2-like and GRIP domain containing 2	11944	0.15
chr2_144454482_144454633	0.38	RP11-434H14.1		14049	0.22
chr6_35838270_35838421	0.38	SRPK1	SRSF protein kinase 1	50479	0.1
chr11_16059814_16059965	0.38	CTD-3096P4.1		15153	0.29
chr21_15963218_15963369	0.38	SAMSN1	SAM domain, SH3 domain and nuclear localization signals 1	7570	0.22
chr1_52043843_52044143	0.38	OSBPL9	oxysterol binding protein-like 9	1142	0.5
chr15_69730252_69730403	0.38	RPLP1	ribosomal protein, large, P1	14796	0.12
chr7_127763401_127763552	0.38	ENSG00000207588	.	41563	0.16
chr15_51878883_51879034	0.38	ENSG00000263437	.	23005	0.17
chr6_11547718_11547869	0.37	TMEM170B	transmembrane protein 170B	9282	0.26
chr8_56777893_56778126	0.37	LYN	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	14363	0.15
chr17_39668679_39668893	0.37	KRT15	keratin 15	5930	0.09
chr1_87801300_87801913	0.37	LMO4	LIM domain only 4	4255	0.35
chr3_11313386_11313537	0.37	ATG7	autophagy related 7	534	0.83
chr19_8605989_8606140	0.37	ENSG00000265528	.	5679	0.12
chr1_99337480_99337815	0.37	RP5-896L10.1		132185	0.05
chr5_122443595_122443791	0.37	AC106786.1		17699	0.16
chr7_36063180_36063480	0.37	PP13004		55364	0.13
chr6_140162934_140163167	0.37	ENSG00000252107	.	316781	0.01
chr6_147224333_147224539	0.37	STXBP5-AS1	STXBP5 antisense RNA 1	8306	0.31
chr2_37576208_37576507	0.37	QPCT	glutaminyl-peptide cyclotransferase	4505	0.2
chr2_40013427_40013578	0.37	SLC8A1-AS1	SLC8A1 antisense RNA 1	91	0.98
chr4_84243203_84243354	0.37	HPSE	heparanase	12657	0.23
chr1_230130880_230131031	0.37	ENSG00000211525	.	54042	0.15
chr1_64697428_64697579	0.37	UBE2U	ubiquitin-conjugating enzyme E2U (putative)	10956	0.25
chr17_47825562_47826034	0.37	FAM117A	family with sequence similarity 117, member A	15695	0.14
chr12_69715526_69715677	0.36	LYZ	lysozyme	26520	0.15
chr16_75099341_75099492	0.36	ZNRF1	zinc and ring finger 1, E3 ubiquitin protein ligase	39266	0.12
chr9_90114264_90114487	0.36	DAPK1	death-associated protein kinase 1	455	0.88
chr14_55494197_55494498	0.36	SOCS4	suppressor of cytokine signaling 4	2	0.91
chr2_105111703_105111854	0.36	ENSG00000199727	.	37453	0.2
chr8_61740550_61740701	0.36	RP11-33I11.2		18460	0.27
chr20_45026696_45026847	0.36	ELMO2	engulfment and cell motility 2	3650	0.26
chr3_128402800_128402979	0.36	RPN1	ribophorin I	2971	0.26
chrX_129121417_129121568	0.36	BCORL1	BCL6 corepressor-like 1	4823	0.24
chr5_130587781_130588081	0.36	CDC42SE2	CDC42 small effector 2	11771	0.27
chr2_174833282_174833433	0.36	SP3	Sp3 transcription factor	2927	0.41
chr2_124505371_124505522	0.36	ENSG00000221689	.	65655	0.14
chr3_61001124_61001482	0.36	ENSG00000212211	.	159026	0.04
chr11_47024468_47024642	0.36	C11orf49	chromosome 11 open reading frame 49	49457	0.12
chr8_68328728_68328879	0.36	ARFGEF1	ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)	72891	0.12
chr12_62722257_62722408	0.36	ENSG00000200814	.	5646	0.23
chr5_171558598_171558763	0.36	ENSG00000266671	.	50700	0.12
chrX_120811108_120811259	0.36	ENSG00000221217	.	191537	0.03
chr9_28922506_28922753	0.36	ENSG00000215939	.	33676	0.22
chr13_96862354_96862505	0.36	ENSG00000242614	.	40630	0.21
chr21_16058568_16058955	0.36	AF165138.7	Protein LOC388813	27619	0.23
chrX_149774865_149775016	0.36	MTM1	myotubularin 1	37847	0.19
chr21_46958089_46958240	0.36	SLC19A1	solute carrier family 19 (folate transporter), member 1	3588	0.27
chr5_148079462_148079613	0.36	HTR4	5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled	34330	0.19

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4

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View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0002430	complement receptor mediated signaling pathway(GO:0002430)
0.1	0.3	GO:0010572	positive regulation of platelet activation(GO:0010572)
0.1	0.3	GO:0019441	tryptophan catabolic process to kynurenine(GO:0019441)
0.1	0.5	GO:0045647	negative regulation of erythrocyte differentiation(GO:0045647)
0.1	0.5	GO:0010886	positive regulation of cholesterol storage(GO:0010886)
0.1	0.2	GO:0009756	carbohydrate mediated signaling(GO:0009756)
0.1	0.3	GO:0045634	regulation of melanocyte differentiation(GO:0045634) regulation of pigment cell differentiation(GO:0050932)
0.1	0.2	GO:0048742	regulation of skeletal muscle fiber development(GO:0048742)
0.1	0.3	GO:0030854	positive regulation of granulocyte differentiation(GO:0030854)
0.1	0.3	GO:0031340	positive regulation of vesicle fusion(GO:0031340)
0.1	0.2	GO:0035461	vitamin transmembrane transport(GO:0035461)
0.1	0.2	GO:0030948	negative regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030948)
0.1	0.2	GO:0072216	positive regulation of metanephros development(GO:0072216)
0.1	0.2	GO:0001821	histamine secretion(GO:0001821)
0.1	0.2	GO:0071436	sodium ion export(GO:0071436)
0.1	0.2	GO:0001779	natural killer cell differentiation(GO:0001779)
0.1	0.2	GO:0032632	interleukin-3 production(GO:0032632)
0.1	0.2	GO:0002138	retinoic acid biosynthetic process(GO:0002138) diterpenoid biosynthetic process(GO:0016102)
0.1	0.2	GO:0015722	canalicular bile acid transport(GO:0015722)
0.0	0.1	GO:0031946	regulation of glucocorticoid biosynthetic process(GO:0031946)
0.0	0.4	GO:0006911	phagocytosis, engulfment(GO:0006911) membrane invagination(GO:0010324)
0.0	0.1	GO:1903224	endodermal cell fate specification(GO:0001714) regulation of endodermal cell fate specification(GO:0042663) regulation of endodermal cell differentiation(GO:1903224)
0.0	0.1	GO:0071569	protein ufmylation(GO:0071569)
0.0	0.1	GO:0060585	regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
0.0	0.2	GO:0006422	aspartyl-tRNA aminoacylation(GO:0006422)
0.0	0.1	GO:0060437	lung growth(GO:0060437)
0.0	0.1	GO:0070672	response to interleukin-15(GO:0070672)
0.0	0.2	GO:0032914	positive regulation of transforming growth factor beta1 production(GO:0032914)
0.0	0.7	GO:0050853	B cell receptor signaling pathway(GO:0050853)
0.0	0.2	GO:0046504	ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
0.0	0.1	GO:0019372	lipoxygenase pathway(GO:0019372)
0.0	0.1	GO:1903429	regulation of neuron maturation(GO:0014041) regulation of cell maturation(GO:1903429)
0.0	0.3	GO:0002634	regulation of germinal center formation(GO:0002634)
0.0	0.1	GO:0017121	phospholipid scrambling(GO:0017121)
0.0	0.0	GO:0032782	bile acid secretion(GO:0032782)
0.0	0.1	GO:0015917	aminophospholipid transport(GO:0015917)
0.0	0.1	GO:0070340	detection of bacterial lipoprotein(GO:0042494) detection of bacterial lipopeptide(GO:0070340)
0.0	0.1	GO:0030210	heparin biosynthetic process(GO:0030210)
0.0	0.0	GO:0001543	ovarian follicle rupture(GO:0001543)
0.0	0.1	GO:0006659	phosphatidylserine biosynthetic process(GO:0006659)
0.0	0.1	GO:0046826	negative regulation of protein export from nucleus(GO:0046826)
0.0	0.2	GO:0006477	protein sulfation(GO:0006477)
0.0	0.1	GO:0010842	retina layer formation(GO:0010842)
0.0	0.4	GO:0051319	mitotic G2 phase(GO:0000085) G2 phase(GO:0051319)
0.0	0.1	GO:0019859	pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) thymine metabolic process(GO:0019859)
0.0	0.1	GO:0015864	pyrimidine nucleoside transport(GO:0015864)
0.0	0.1	GO:0010508	positive regulation of autophagy(GO:0010508)
0.0	0.2	GO:0006991	response to sterol depletion(GO:0006991)
0.0	0.1	GO:0002495	antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.0	0.1	GO:0060028	convergent extension involved in axis elongation(GO:0060028)
0.0	0.0	GO:0021873	forebrain neuroblast division(GO:0021873)
0.0	0.1	GO:0019852	L-ascorbic acid metabolic process(GO:0019852)
0.0	0.1	GO:0034122	negative regulation of toll-like receptor signaling pathway(GO:0034122)
0.0	0.1	GO:0032959	inositol trisphosphate biosynthetic process(GO:0032959)
0.0	0.1	GO:0045578	negative regulation of B cell differentiation(GO:0045578)
0.0	0.2	GO:0006610	ribosomal protein import into nucleus(GO:0006610)
0.0	0.1	GO:0032467	positive regulation of cytokinesis(GO:0032467)
0.0	0.1	GO:0002248	connective tissue replacement involved in inflammatory response wound healing(GO:0002248) connective tissue replacement(GO:0097709)
0.0	0.1	GO:0032957	inositol trisphosphate metabolic process(GO:0032957)
0.0	0.1	GO:0010193	response to ozone(GO:0010193)
0.0	0.2	GO:0006776	vitamin A metabolic process(GO:0006776)
0.0	0.5	GO:0016998	cell wall macromolecule catabolic process(GO:0016998)
0.0	0.1	GO:0071379	cellular response to prostaglandin stimulus(GO:0071379)
0.0	0.1	GO:0036336	dendritic cell chemotaxis(GO:0002407) dendritic cell migration(GO:0036336)
0.0	0.1	GO:0051570	regulation of histone H3-K9 methylation(GO:0051570)
0.0	0.1	GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process(GO:0051770)
0.0	0.1	GO:0032836	glomerular basement membrane development(GO:0032836)
0.0	0.1	GO:0043653	mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.0	0.1	GO:0019530	taurine metabolic process(GO:0019530)
0.0	0.1	GO:0071360	cellular response to exogenous dsRNA(GO:0071360)
0.0	0.1	GO:0048478	replication fork protection(GO:0048478)
0.0	0.1	GO:0045091	regulation of single stranded viral RNA replication via double stranded DNA intermediate(GO:0045091)
0.0	0.1	GO:0090292	nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0	0.1	GO:0001778	plasma membrane repair(GO:0001778)
0.0	0.2	GO:0015671	oxygen transport(GO:0015671)
0.0	0.1	GO:0006654	phosphatidic acid biosynthetic process(GO:0006654)
0.0	0.1	GO:0019695	choline metabolic process(GO:0019695)
0.0	0.1	GO:0051387	negative regulation of neurotrophin TRK receptor signaling pathway(GO:0051387)
0.0	0.1	GO:0060665	regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.0	0.1	GO:0009249	protein lipoylation(GO:0009249)
0.0	0.1	GO:0090231	regulation of spindle checkpoint(GO:0090231)
0.0	0.1	GO:0042117	monocyte activation(GO:0042117)
0.0	0.1	GO:1901419	regulation of response to alcohol(GO:1901419)
0.0	0.1	GO:0010642	negative regulation of platelet-derived growth factor receptor signaling pathway(GO:0010642)
0.0	0.4	GO:0021846	cell proliferation in forebrain(GO:0021846)
0.0	0.1	GO:1904358	positive regulation of telomere maintenance via telomerase(GO:0032212) positive regulation of telomere maintenance via telomere lengthening(GO:1904358)
0.0	0.1	GO:0033629	negative regulation of cell adhesion mediated by integrin(GO:0033629)
0.0	0.1	GO:0003078	obsolete regulation of natriuresis(GO:0003078)
0.0	0.1	GO:0006564	L-serine biosynthetic process(GO:0006564)
0.0	0.1	GO:0007406	negative regulation of neuroblast proliferation(GO:0007406) negative regulation of neural precursor cell proliferation(GO:2000178)
0.0	0.2	GO:0006570	tyrosine metabolic process(GO:0006570)
0.0	0.1	GO:0055098	response to low-density lipoprotein particle(GO:0055098)
0.0	0.1	GO:0001992	regulation of systemic arterial blood pressure by vasopressin(GO:0001992)
0.0	0.5	GO:0030032	lamellipodium assembly(GO:0030032)
0.0	0.0	GO:0046881	positive regulation of gonadotropin secretion(GO:0032278) positive regulation of follicle-stimulating hormone secretion(GO:0046881)
0.0	0.1	GO:0008215	spermine metabolic process(GO:0008215)
0.0	0.1	GO:0009414	response to water deprivation(GO:0009414) response to water(GO:0009415)
0.0	0.1	GO:0010447	response to acidic pH(GO:0010447)
0.0	0.1	GO:1903332	regulation of protein folding(GO:1903332)
0.0	0.2	GO:0015884	folic acid transport(GO:0015884)
0.0	0.1	GO:0003056	regulation of vascular smooth muscle contraction(GO:0003056)
0.0	0.1	GO:0032509	endosome transport via multivesicular body sorting pathway(GO:0032509)
0.0	0.2	GO:0051593	response to folic acid(GO:0051593)
0.0	0.0	GO:0046101	hypoxanthine biosynthetic process(GO:0046101)
0.0	0.0	GO:0042159	lipoprotein catabolic process(GO:0042159)
0.0	0.4	GO:0050832	defense response to fungus(GO:0050832)
0.0	0.2	GO:0033683	nucleotide-excision repair, DNA incision(GO:0033683)
0.0	0.1	GO:0032227	negative regulation of synaptic transmission, dopaminergic(GO:0032227)
0.0	0.3	GO:0001556	oocyte maturation(GO:0001556)
0.0	0.0	GO:0009405	pathogenesis(GO:0009405)
0.0	0.1	GO:0048170	positive regulation of long-term neuronal synaptic plasticity(GO:0048170)
0.0	0.2	GO:0001561	fatty acid alpha-oxidation(GO:0001561)
0.0	0.0	GO:2000050	regulation of non-canonical Wnt signaling pathway(GO:2000050) regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000095)
0.0	0.1	GO:0060083	smooth muscle contraction involved in micturition(GO:0060083)
0.0	0.1	GO:0097576	vacuole fusion(GO:0097576)
0.0	0.2	GO:0009396	folic acid-containing compound biosynthetic process(GO:0009396)
0.0	0.1	GO:0071699	olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.0	0.1	GO:0006685	sphingomyelin catabolic process(GO:0006685)
0.0	0.0	GO:0048087	positive regulation of developmental pigmentation(GO:0048087)
0.0	0.1	GO:0070584	mitochondrion morphogenesis(GO:0070584)
0.0	0.1	GO:0002025	vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure(GO:0002025)
0.0	0.0	GO:0032776	DNA methylation on cytosine(GO:0032776) C-5 methylation of cytosine(GO:0090116)
0.0	0.0	GO:0090030	regulation of steroid hormone biosynthetic process(GO:0090030)
0.0	0.0	GO:0006106	fumarate metabolic process(GO:0006106)
0.0	0.0	GO:0048388	endosomal lumen acidification(GO:0048388)
0.0	0.0	GO:0048670	regulation of collateral sprouting(GO:0048670)
0.0	0.0	GO:0051461	corticotropin secretion(GO:0051458) regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461)
0.0	0.0	GO:0019532	oxalate transport(GO:0019532)
0.0	0.0	GO:1903960	negative regulation of plasma membrane long-chain fatty acid transport(GO:0010748) negative regulation of anion transmembrane transport(GO:1903960) negative regulation of fatty acid transport(GO:2000192)
0.0	0.1	GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress(GO:0008631) cell death in response to oxidative stress(GO:0036473)
0.0	0.0	GO:0072531	pyrimidine-containing compound transmembrane transport(GO:0072531)
0.0	0.1	GO:0006614	SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.0	0.0	GO:0002523	leukocyte migration involved in inflammatory response(GO:0002523)
0.0	0.1	GO:2000171	negative regulation of dendrite development(GO:2000171)
0.0	0.1	GO:0006667	sphinganine metabolic process(GO:0006667)
0.0	0.1	GO:0045356	positive regulation of interferon-alpha biosynthetic process(GO:0045356)
0.0	0.1	GO:0045408	regulation of interleukin-6 biosynthetic process(GO:0045408)
0.0	0.1	GO:0010966	regulation of phosphate transport(GO:0010966)
0.0	0.1	GO:0033147	negative regulation of intracellular estrogen receptor signaling pathway(GO:0033147)
0.0	0.1	GO:0051151	negative regulation of smooth muscle cell differentiation(GO:0051151)
0.0	0.1	GO:0070634	transepithelial ammonium transport(GO:0070634)
0.0	0.2	GO:0032008	positive regulation of TOR signaling(GO:0032008)
0.0	0.0	GO:0048669	collateral sprouting in absence of injury(GO:0048669)
0.0	0.1	GO:0007028	cytoplasm organization(GO:0007028)
0.0	0.1	GO:0002726	positive regulation of T cell cytokine production(GO:0002726)
0.0	0.1	GO:0000712	resolution of meiotic recombination intermediates(GO:0000712) meiotic chromosome separation(GO:0051307)
0.0	0.0	GO:0043320	natural killer cell activation involved in immune response(GO:0002323) natural killer cell degranulation(GO:0043320)
0.0	0.0	GO:0060059	embryonic retina morphogenesis in camera-type eye(GO:0060059)
0.0	0.1	GO:0031536	positive regulation of exit from mitosis(GO:0031536)
0.0	0.3	GO:0032012	regulation of ARF protein signal transduction(GO:0032012)
0.0	0.1	GO:0032543	mitochondrial translation(GO:0032543)
0.0	0.1	GO:0031060	regulation of histone methylation(GO:0031060)
0.0	0.1	GO:0010898	regulation of triglyceride catabolic process(GO:0010896) positive regulation of triglyceride catabolic process(GO:0010898)
0.0	0.1	GO:0010586	miRNA metabolic process(GO:0010586) miRNA catabolic process(GO:0010587)
0.0	0.1	GO:0042149	cellular response to glucose starvation(GO:0042149)
0.0	0.1	GO:0010988	regulation of low-density lipoprotein particle clearance(GO:0010988)
0.0	0.1	GO:0031580	membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.0	0.1	GO:0090073	positive regulation of protein homodimerization activity(GO:0090073)
0.0	0.1	GO:0050651	dermatan sulfate proteoglycan biosynthetic process(GO:0050651)
0.0	0.1	GO:0060164	regulation of timing of neuron differentiation(GO:0060164)
0.0	0.1	GO:0060014	granulosa cell differentiation(GO:0060014)
0.0	0.4	GO:0006071	glycerol metabolic process(GO:0006071)
0.0	0.1	GO:0001661	conditioned taste aversion(GO:0001661)
0.0	0.0	GO:0021831	embryonic olfactory bulb interneuron precursor migration(GO:0021831) chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration(GO:0021834)
0.0	0.1	GO:0071692	sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.0	0.1	GO:0035610	C-terminal protein deglutamylation(GO:0035609) protein side chain deglutamylation(GO:0035610)
0.0	0.1	GO:0043584	nose development(GO:0043584)
0.0	0.1	GO:0046469	platelet activating factor metabolic process(GO:0046469)
0.0	0.0	GO:0032966	negative regulation of collagen metabolic process(GO:0010713) negative regulation of collagen biosynthetic process(GO:0032966) negative regulation of multicellular organismal metabolic process(GO:0044252)
0.0	0.1	GO:0021707	cerebellar granular layer development(GO:0021681) cerebellar granular layer morphogenesis(GO:0021683) cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.0	0.0	GO:0045650	negative regulation of macrophage differentiation(GO:0045650)
0.0	0.0	GO:0033194	response to hydroperoxide(GO:0033194)
0.0	0.1	GO:0019987	obsolete negative regulation of anti-apoptosis(GO:0019987)
0.0	0.0	GO:0045077	negative regulation of interferon-gamma biosynthetic process(GO:0045077)
0.0	0.1	GO:0008228	opsonization(GO:0008228)
0.0	0.1	GO:0052803	imidazole-containing compound metabolic process(GO:0052803)
0.0	0.0	GO:0043162	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.0	0.1	GO:0043496	regulation of protein homodimerization activity(GO:0043496)
0.0	0.0	GO:0032780	negative regulation of ATPase activity(GO:0032780)
0.0	0.1	GO:0006895	Golgi to endosome transport(GO:0006895) Golgi to vacuole transport(GO:0006896)
0.0	0.0	GO:0006290	pyrimidine dimer repair(GO:0006290)
0.0	0.1	GO:0043302	positive regulation of mast cell activation involved in immune response(GO:0033008) positive regulation of leukocyte degranulation(GO:0043302) positive regulation of mast cell degranulation(GO:0043306)
0.0	0.0	GO:0016576	histone dephosphorylation(GO:0016576)
0.0	0.0	GO:0032106	positive regulation of response to food(GO:0032097) positive regulation of appetite(GO:0032100) positive regulation of response to extracellular stimulus(GO:0032106) positive regulation of response to nutrient levels(GO:0032109)
0.0	0.0	GO:0007100	mitotic centrosome separation(GO:0007100)
0.0	0.1	GO:0006515	misfolded or incompletely synthesized protein catabolic process(GO:0006515)
0.0	0.1	GO:0002830	positive regulation of type 2 immune response(GO:0002830) positive regulation of T-helper 2 cell differentiation(GO:0045630)
0.0	0.1	GO:0007185	transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0	0.1	GO:0034375	high-density lipoprotein particle remodeling(GO:0034375)
0.0	0.2	GO:0007128	meiotic prophase I(GO:0007128)
0.0	0.0	GO:0007262	STAT protein import into nucleus(GO:0007262)
0.0	0.0	GO:0021535	cell migration in hindbrain(GO:0021535)
0.0	0.1	GO:0030644	cellular chloride ion homeostasis(GO:0030644) chloride ion homeostasis(GO:0055064)
0.0	0.2	GO:0009595	detection of biotic stimulus(GO:0009595)
0.0	0.0	GO:0006531	aspartate metabolic process(GO:0006531) aspartate catabolic process(GO:0006533)
0.0	0.1	GO:0050957	equilibrioception(GO:0050957)
0.0	0.0	GO:0060972	left/right pattern formation(GO:0060972)
0.0	0.0	GO:0035067	negative regulation of histone acetylation(GO:0035067) negative regulation of protein acetylation(GO:1901984) negative regulation of peptidyl-lysine acetylation(GO:2000757)
0.0	0.1	GO:0072386	plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.0	0.2	GO:0045730	respiratory burst(GO:0045730)
0.0	0.1	GO:0046487	glyoxylate metabolic process(GO:0046487)
0.0	0.1	GO:0070071	proton-transporting two-sector ATPase complex assembly(GO:0070071)
0.0	0.1	GO:0071391	cellular response to estrogen stimulus(GO:0071391)
0.0	0.1	GO:0045347	negative regulation of MHC class II biosynthetic process(GO:0045347)
0.0	0.2	GO:0009268	response to pH(GO:0009268)
0.0	0.2	GO:0006662	glycerol ether metabolic process(GO:0006662) ether metabolic process(GO:0018904)
0.0	0.0	GO:0006925	inflammatory cell apoptotic process(GO:0006925)
0.0	0.1	GO:0043568	positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568)
0.0	0.1	GO:0010894	negative regulation of steroid biosynthetic process(GO:0010894)
0.0	0.0	GO:0040016	embryonic cleavage(GO:0040016)
0.0	0.2	GO:1903846	positive regulation of transforming growth factor beta receptor signaling pathway(GO:0030511) positive regulation of cellular response to transforming growth factor beta stimulus(GO:1903846)
0.0	0.0	GO:0001845	phagolysosome assembly(GO:0001845) phagosome maturation(GO:0090382)
0.0	0.0	GO:0032808	lacrimal gland development(GO:0032808)
0.0	0.0	GO:0010470	regulation of gastrulation(GO:0010470)
0.0	0.1	GO:0045176	apical protein localization(GO:0045176)
0.0	0.0	GO:0051124	synaptic growth at neuromuscular junction(GO:0051124)
0.0	0.1	GO:0018106	peptidyl-histidine phosphorylation(GO:0018106)
0.0	0.0	GO:0032927	positive regulation of activin receptor signaling pathway(GO:0032927)
0.0	0.1	GO:0045600	positive regulation of fat cell differentiation(GO:0045600)
0.0	0.3	GO:0051318	G1 phase(GO:0051318)
0.0	0.1	GO:0072526	pyridine-containing compound catabolic process(GO:0072526)
0.0	0.0	GO:0070669	response to interleukin-2(GO:0070669)
0.0	0.3	GO:0006891	intra-Golgi vesicle-mediated transport(GO:0006891)
0.0	0.1	GO:0032306	regulation of icosanoid secretion(GO:0032303) positive regulation of icosanoid secretion(GO:0032305) regulation of prostaglandin secretion(GO:0032306) positive regulation of prostaglandin secretion(GO:0032308) prostaglandin secretion(GO:0032310)
0.0	0.0	GO:0002674	negative regulation of acute inflammatory response(GO:0002674)
0.0	0.1	GO:0046835	carbohydrate phosphorylation(GO:0046835)
0.0	0.0	GO:0002331	pre-B cell allelic exclusion(GO:0002331)
0.0	0.3	GO:0015914	phospholipid transport(GO:0015914)
0.0	0.1	GO:0002544	chronic inflammatory response(GO:0002544)
0.0	0.1	GO:0060287	epithelial cilium movement(GO:0003351) epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
0.0	0.0	GO:0034638	phosphatidylcholine catabolic process(GO:0034638)
0.0	0.1	GO:0045084	positive regulation of interleukin-12 biosynthetic process(GO:0045084)
0.0	0.1	GO:0030889	negative regulation of B cell proliferation(GO:0030889)
0.0	0.1	GO:0051016	barbed-end actin filament capping(GO:0051016)
0.0	0.1	GO:0034587	piRNA metabolic process(GO:0034587)
0.0	0.0	GO:0043931	ossification involved in bone maturation(GO:0043931)
0.0	0.0	GO:0008628	hormone-mediated apoptotic signaling pathway(GO:0008628)
0.0	0.0	GO:0006122	mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.0	0.1	GO:0060009	Sertoli cell development(GO:0060009)
0.0	0.1	GO:0034331	cell junction maintenance(GO:0034331) cell-cell junction maintenance(GO:0045217)
0.0	0.0	GO:0070837	dehydroascorbic acid transport(GO:0070837)
0.0	0.1	GO:0007635	chemosensory behavior(GO:0007635)
0.0	0.1	GO:0010225	response to UV-C(GO:0010225)
0.0	0.1	GO:0042989	sequestering of actin monomers(GO:0042989)
0.0	0.0	GO:0002093	auditory receptor cell morphogenesis(GO:0002093) auditory receptor cell stereocilium organization(GO:0060088)
0.0	0.0	GO:0060539	diaphragm development(GO:0060539)
0.0	0.0	GO:0045292	mRNA cis splicing, via spliceosome(GO:0045292)
0.0	0.0	GO:0061001	dendritic spine morphogenesis(GO:0060997) regulation of dendritic spine morphogenesis(GO:0061001) dendritic spine organization(GO:0097061)
0.0	0.0	GO:0009235	cobalamin metabolic process(GO:0009235)
0.0	0.0	GO:0048284	organelle fusion(GO:0048284)
0.0	0.0	GO:0014052	gamma-aminobutyric acid secretion(GO:0014051) regulation of gamma-aminobutyric acid secretion(GO:0014052)
0.0	0.0	GO:0015959	diadenosine polyphosphate metabolic process(GO:0015959)
0.0	0.1	GO:0044245	polysaccharide digestion(GO:0044245)
0.0	0.5	GO:0061025	membrane fusion(GO:0061025)
0.0	0.1	GO:0097191	extrinsic apoptotic signaling pathway via death domain receptors(GO:0008625) extrinsic apoptotic signaling pathway(GO:0097191)
0.0	0.0	GO:0042253	granulocyte macrophage colony-stimulating factor biosynthetic process(GO:0042253)
0.0	0.1	GO:0007029	endoplasmic reticulum organization(GO:0007029)
0.0	0.0	GO:0009051	pentose-phosphate shunt, oxidative branch(GO:0009051)
0.0	0.0	GO:0002313	mature B cell differentiation involved in immune response(GO:0002313)
0.0	0.0	GO:0014832	urinary bladder smooth muscle contraction(GO:0014832)
0.0	0.0	GO:0019805	quinolinate biosynthetic process(GO:0019805)
0.0	0.0	GO:0070373	negative regulation of ERK1 and ERK2 cascade(GO:0070373)
0.0	0.0	GO:0045603	positive regulation of endothelial cell differentiation(GO:0045603)
0.0	0.1	GO:0050775	positive regulation of dendrite morphogenesis(GO:0050775)
0.0	0.0	GO:0006907	pinocytosis(GO:0006907)
0.0	0.1	GO:0016075	rRNA catabolic process(GO:0016075)
0.0	0.0	GO:0007252	I-kappaB phosphorylation(GO:0007252)
0.0	0.0	GO:0032717	negative regulation of interleukin-8 production(GO:0032717)
0.0	0.0	GO:0072583	synaptic vesicle recycling(GO:0036465) synaptic vesicle endocytosis(GO:0048488) clathrin-mediated endocytosis(GO:0072583)
0.0	0.1	GO:0048895	sensory system development(GO:0048880) lateral line nerve development(GO:0048892) lateral line nerve glial cell differentiation(GO:0048895) lateral line system development(GO:0048925) lateral line nerve glial cell development(GO:0048937) iridophore differentiation(GO:0050935)
0.0	0.0	GO:0048261	negative regulation of receptor-mediated endocytosis(GO:0048261)
0.0	0.0	GO:0045723	positive regulation of fatty acid biosynthetic process(GO:0045723)
0.0	0.0	GO:0002478	antigen processing and presentation of exogenous peptide antigen(GO:0002478)
0.0	0.0	GO:0006432	phenylalanyl-tRNA aminoacylation(GO:0006432)
0.0	0.1	GO:0042435	indole-containing compound biosynthetic process(GO:0042435)
0.0	0.0	GO:0051324	prophase(GO:0051324)
0.0	0.1	GO:0008356	asymmetric cell division(GO:0008356)
0.0	0.4	GO:0071377	cellular response to glucagon stimulus(GO:0071377)
0.0	0.0	GO:0045075	interleukin-12 biosynthetic process(GO:0042090) regulation of interleukin-12 biosynthetic process(GO:0045075)
0.0	0.1	GO:0006349	regulation of gene expression by genetic imprinting(GO:0006349)
0.0	0.0	GO:0033119	negative regulation of RNA splicing(GO:0033119)
0.0	0.0	GO:0018242	protein O-linked glycosylation via serine(GO:0018242) protein O-linked glycosylation via threonine(GO:0018243)
0.0	0.1	GO:0007386	compartment pattern specification(GO:0007386)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0031313	extrinsic component of vacuolar membrane(GO:0000306) extrinsic component of endosome membrane(GO:0031313)
0.1	0.3	GO:0031588	nucleotide-activated protein kinase complex(GO:0031588)
0.0	0.2	GO:0031092	platelet alpha granule membrane(GO:0031092)
0.0	0.1	GO:0031618	nuclear pericentric heterochromatin(GO:0031618)
0.0	0.2	GO:0001739	sex chromatin(GO:0001739)
0.0	0.4	GO:0034362	low-density lipoprotein particle(GO:0034362)
0.0	0.1	GO:0031205	endoplasmic reticulum Sec complex(GO:0031205)
0.0	0.2	GO:0033162	melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.0	0.1	GO:0042583	chromaffin granule(GO:0042583) chromaffin granule membrane(GO:0042584)
0.0	0.9	GO:0005626	obsolete insoluble fraction(GO:0005626)
0.0	0.1	GO:0043218	compact myelin(GO:0043218)
0.0	0.3	GO:0005675	holo TFIIH complex(GO:0005675)
0.0	0.3	GO:0030315	T-tubule(GO:0030315)
0.0	0.1	GO:0043259	laminin-10 complex(GO:0043259)
0.0	0.1	GO:0032809	neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0	0.1	GO:0042598	obsolete vesicular fraction(GO:0042598)
0.0	0.0	GO:0071664	catenin-TCF7L2 complex(GO:0071664)
0.0	0.1	GO:0030061	mitochondrial crista(GO:0030061)
0.0	0.1	GO:0005662	DNA replication factor A complex(GO:0005662)
0.0	0.1	GO:0000942	condensed nuclear chromosome outer kinetochore(GO:0000942)
0.0	0.1	GO:0070083	clathrin-sculpted monoamine transport vesicle(GO:0070081) clathrin-sculpted monoamine transport vesicle membrane(GO:0070083)
0.0	0.2	GO:0000145	exocyst(GO:0000145)
0.0	0.1	GO:0032009	early phagosome(GO:0032009)
0.0	0.1	GO:0042581	specific granule(GO:0042581)
0.0	0.6	GO:0031907	peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0	0.1	GO:0031265	CD95 death-inducing signaling complex(GO:0031265)
0.0	0.1	GO:0032133	chromosome passenger complex(GO:0032133)
0.0	0.1	GO:0005958	DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958)
0.0	0.1	GO:0033018	sarcoplasmic reticulum lumen(GO:0033018)
0.0	0.1	GO:0019773	proteasome core complex, alpha-subunit complex(GO:0019773)
0.0	0.1	GO:0042627	chylomicron(GO:0042627)
0.0	0.2	GO:0008180	COP9 signalosome(GO:0008180)
0.0	0.1	GO:0046581	intercellular canaliculus(GO:0046581)
0.0	0.1	GO:0005786	signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.0	0.3	GO:0030530	obsolete heterogeneous nuclear ribonucleoprotein complex(GO:0030530)
0.0	0.0	GO:0031932	TORC2 complex(GO:0031932)
0.0	0.2	GO:0008250	oligosaccharyltransferase complex(GO:0008250)
0.0	0.1	GO:0043020	NADPH oxidase complex(GO:0043020)
0.0	0.0	GO:0042629	mast cell granule(GO:0042629)
0.0	0.1	GO:0032839	dendrite cytoplasm(GO:0032839)
0.0	0.0	GO:0071986	Ragulator complex(GO:0071986)
0.0	0.1	GO:0045275	mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.0	0.0	GO:0030663	COPI-coated vesicle membrane(GO:0030663)
0.0	0.1	GO:0005915	zonula adherens(GO:0005915)
0.0	0.1	GO:0042827	platelet dense granule(GO:0042827)
0.0	0.0	GO:0038201	TOR complex(GO:0038201)
0.0	0.2	GO:0030667	secretory granule membrane(GO:0030667)
0.0	0.1	GO:0030992	intraciliary transport particle B(GO:0030992)
0.0	0.3	GO:0001533	cornified envelope(GO:0001533)
0.0	0.1	GO:0005672	transcription factor TFIIA complex(GO:0005672)
0.0	0.2	GO:0030057	desmosome(GO:0030057)
0.0	0.1	GO:0030126	COPI vesicle coat(GO:0030126)
0.0	0.1	GO:0005853	eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0	0.1	GO:0030904	retromer complex(GO:0030904)
0.0	0.1	GO:0001931	uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0	0.1	GO:0042588	zymogen granule(GO:0042588)
0.0	0.1	GO:0001518	voltage-gated sodium channel complex(GO:0001518)
0.0	0.2	GO:0045335	phagocytic vesicle(GO:0045335)
0.0	0.0	GO:0031933	telomeric heterochromatin(GO:0031933)
0.0	0.1	GO:0042582	primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.0	0.1	GO:0016281	eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0	0.0	GO:0031371	ubiquitin conjugating enzyme complex(GO:0031371)
0.0	0.1	GO:0097425	smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.0	0.5	GO:0031901	early endosome membrane(GO:0031901)
0.0	0.1	GO:0035098	ESC/E(Z) complex(GO:0035098)
0.0	0.1	GO:0031528	microvillus membrane(GO:0031528)
0.0	0.1	GO:0031941	filamentous actin(GO:0031941)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0004875	complement receptor activity(GO:0004875)
0.1	0.3	GO:0004833	tryptophan 2,3-dioxygenase activity(GO:0004833)
0.1	0.3	GO:0004465	lipoprotein lipase activity(GO:0004465)
0.1	0.3	GO:0005350	pyrimidine nucleobase transmembrane transporter activity(GO:0005350)
0.1	0.2	GO:0001758	retinal dehydrogenase activity(GO:0001758)
0.1	0.3	GO:0019911	structural constituent of myelin sheath(GO:0019911)
0.1	0.2	GO:0001159	RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.1	0.2	GO:0045118	azole transporter activity(GO:0045118) azole transmembrane transporter activity(GO:1901474)
0.1	0.2	GO:0019763	immunoglobulin receptor activity(GO:0019763)
0.1	0.2	GO:0019834	phospholipase A2 inhibitor activity(GO:0019834)
0.1	0.5	GO:0030676	Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.1	0.2	GO:0050253	retinyl-palmitate esterase activity(GO:0050253)
0.1	0.3	GO:0052813	phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.1	0.2	GO:0004167	dopachrome isomerase activity(GO:0004167)
0.1	0.2	GO:0033691	sialic acid binding(GO:0033691)
0.1	0.2	GO:0042808	obsolete neuronal Cdc2-like kinase binding(GO:0042808)
0.1	0.2	GO:0032558	purine deoxyribonucleotide binding(GO:0032554) adenyl deoxyribonucleotide binding(GO:0032558)
0.0	0.2	GO:0005432	calcium:sodium antiporter activity(GO:0005432)
0.0	0.2	GO:0004904	interferon receptor activity(GO:0004904)
0.0	0.1	GO:0003953	NAD+ nucleosidase activity(GO:0003953)
0.0	0.2	GO:0004815	aspartate-tRNA ligase activity(GO:0004815)
0.0	0.6	GO:0030169	low-density lipoprotein particle binding(GO:0030169)
0.0	0.3	GO:0001784	phosphotyrosine binding(GO:0001784)
0.0	1.0	GO:0045028	G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0	0.1	GO:0017128	phospholipid scramblase activity(GO:0017128)
0.0	0.1	GO:0008518	reduced folate carrier activity(GO:0008518)
0.0	0.3	GO:0004908	interleukin-1 receptor activity(GO:0004908)
0.0	0.1	GO:0008109	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0	0.1	GO:0031705	bombesin receptor binding(GO:0031705) endothelin B receptor binding(GO:0031708)
0.0	0.1	GO:0004514	nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514)
0.0	0.4	GO:0016565	obsolete general transcriptional repressor activity(GO:0016565)
0.0	0.1	GO:0031957	very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0	0.3	GO:0019864	IgG binding(GO:0019864)
0.0	0.3	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0	0.1	GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0	0.2	GO:0005087	Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.0	0.1	GO:0008327	methyl-CpG binding(GO:0008327)
0.0	0.2	GO:0030955	potassium ion binding(GO:0030955)
0.0	0.1	GO:0016882	cyclo-ligase activity(GO:0016882)
0.0	0.1	GO:0098847	single-stranded telomeric DNA binding(GO:0043047) sequence-specific single stranded DNA binding(GO:0098847)
0.0	0.2	GO:0043208	glycosphingolipid binding(GO:0043208)
0.0	0.1	GO:0004677	DNA-dependent protein kinase activity(GO:0004677)
0.0	0.2	GO:0047035	testosterone dehydrogenase (NAD+) activity(GO:0047035)
0.0	0.2	GO:0004075	biotin carboxylase activity(GO:0004075)
0.0	0.1	GO:0015037	peptide disulfide oxidoreductase activity(GO:0015037)
0.0	0.2	GO:0016520	growth hormone-releasing hormone receptor activity(GO:0016520)
0.0	0.1	GO:0004566	beta-glucuronidase activity(GO:0004566)
0.0	0.1	GO:0003987	acetate-CoA ligase activity(GO:0003987)
0.0	0.1	GO:0015204	urea transmembrane transporter activity(GO:0015204)
0.0	0.5	GO:0004012	phospholipid-translocating ATPase activity(GO:0004012)
0.0	0.1	GO:0019959	C-X-C chemokine binding(GO:0019958) interleukin-8 binding(GO:0019959)
0.0	0.1	GO:0001846	opsonin binding(GO:0001846)
0.0	0.2	GO:0005522	profilin binding(GO:0005522)
0.0	0.2	GO:0008889	glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.0	0.1	GO:0030881	beta-2-microglobulin binding(GO:0030881)
0.0	0.1	GO:0043175	RNA polymerase core enzyme binding(GO:0043175)
0.0	0.1	GO:0016149	translation release factor activity, codon specific(GO:0016149)
0.0	0.2	GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0	0.2	GO:0050786	RAGE receptor binding(GO:0050786)
0.0	0.2	GO:0004969	histamine receptor activity(GO:0004969)
0.0	0.1	GO:0045236	CXCR chemokine receptor binding(GO:0045236)
0.0	0.1	GO:0008331	high voltage-gated calcium channel activity(GO:0008331)
0.0	0.2	GO:0008139	nuclear localization sequence binding(GO:0008139)
0.0	0.1	GO:0070273	phosphatidylinositol-4-phosphate binding(GO:0070273)
0.0	0.1	GO:0008454	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0	0.1	GO:0050544	arachidonic acid binding(GO:0050544)
0.0	0.0	GO:0050542	icosanoid binding(GO:0050542) fatty acid derivative binding(GO:1901567)
0.0	0.1	GO:0048039	ubiquinone binding(GO:0048039)
0.0	0.1	GO:0031849	olfactory receptor binding(GO:0031849)
0.0	0.1	GO:0070290	N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0	0.1	GO:0004030	aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.0	0.0	GO:0003829	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0003829)
0.0	0.1	GO:0005047	signal recognition particle binding(GO:0005047)
0.0	0.1	GO:0033743	peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.0	0.2	GO:0008641	small protein activating enzyme activity(GO:0008641)
0.0	0.1	GO:0033130	acetylcholine receptor binding(GO:0033130)
0.0	0.2	GO:0043325	phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0	0.1	GO:0004645	phosphorylase activity(GO:0004645)
0.0	0.4	GO:0030552	cAMP binding(GO:0030552)
0.0	0.2	GO:0016018	cyclosporin A binding(GO:0016018)
0.0	0.1	GO:0004939	beta-adrenergic receptor activity(GO:0004939)
0.0	0.2	GO:0015645	fatty acid ligase activity(GO:0015645)
0.0	0.1	GO:0042577	lipid phosphatase activity(GO:0042577)
0.0	0.1	GO:0050220	prostaglandin-E synthase activity(GO:0050220)
0.0	0.1	GO:0004767	sphingomyelin phosphodiesterase activity(GO:0004767)
0.0	0.2	GO:0004622	lysophospholipase activity(GO:0004622)
0.0	0.2	GO:0051787	misfolded protein binding(GO:0051787)
0.0	0.1	GO:0004663	Rab geranylgeranyltransferase activity(GO:0004663)
0.0	0.1	GO:0015347	sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.0	0.1	GO:0005030	neurotrophin receptor activity(GO:0005030)
0.0	0.1	GO:0070097	delta-catenin binding(GO:0070097)
0.0	0.2	GO:0003906	DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906)
0.0	0.3	GO:0005086	ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0	0.1	GO:0004477	methenyltetrahydrofolate cyclohydrolase activity(GO:0004477)
0.0	0.1	GO:0016494	C-X-C chemokine receptor activity(GO:0016494)
0.0	0.1	GO:0016509	long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0016509)
0.0	0.1	GO:0004032	alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.0	0.1	GO:0016303	1-phosphatidylinositol-3-kinase activity(GO:0016303) phosphatidylinositol 3-kinase activity(GO:0035004)
0.0	0.1	GO:0003846	2-acylglycerol O-acyltransferase activity(GO:0003846)
0.0	0.1	GO:0005132	type I interferon receptor binding(GO:0005132)
0.0	0.1	GO:0032266	phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0	0.2	GO:0005344	oxygen transporter activity(GO:0005344)
0.0	0.1	GO:0015016	[heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0	0.1	GO:0016972	thiol oxidase activity(GO:0016972)
0.0	0.1	GO:0016748	succinyltransferase activity(GO:0016748)
0.0	0.1	GO:0004597	peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.0	0.1	GO:0047760	butyrate-CoA ligase activity(GO:0047760)
0.0	0.1	GO:0000293	ferric-chelate reductase activity(GO:0000293)
0.0	0.1	GO:0019788	NEDD8 transferase activity(GO:0019788)
0.0	0.1	GO:0070579	methylcytosine dioxygenase activity(GO:0070579)
0.0	0.2	GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0	0.0	GO:0098599	palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0	0.1	GO:0004803	transposase activity(GO:0004803)
0.0	0.1	GO:0004062	aryl sulfotransferase activity(GO:0004062)
0.0	0.0	GO:0047756	chondroitin 4-sulfotransferase activity(GO:0047756)
0.0	0.3	GO:0031683	G-protein beta/gamma-subunit complex binding(GO:0031683)
0.0	0.1	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0	0.1	GO:0030276	clathrin binding(GO:0030276)
0.0	0.1	GO:0016857	racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.0	0.1	GO:0046974	histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.0	0.1	GO:0005536	glucose binding(GO:0005536)
0.0	0.1	GO:0016175	superoxide-generating NADPH oxidase activity(GO:0016175)
0.0	0.0	GO:0017159	pantetheine hydrolase activity(GO:0017159)
0.0	0.1	GO:0032454	histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0	0.1	GO:0019136	deoxynucleoside kinase activity(GO:0019136)
0.0	0.1	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.0	0.1	GO:0008467	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0	0.7	GO:0008009	chemokine activity(GO:0008009)
0.0	0.0	GO:0004351	glutamate decarboxylase activity(GO:0004351)
0.0	0.1	GO:0000339	RNA cap binding(GO:0000339)
0.0	0.0	GO:0050693	LBD domain binding(GO:0050693)
0.0	0.0	GO:0019531	oxalate transmembrane transporter activity(GO:0019531)
0.0	0.1	GO:0045569	TRAIL binding(GO:0045569)
0.0	0.2	GO:0099589	G-protein coupled serotonin receptor activity(GO:0004993) serotonin receptor activity(GO:0099589)
0.0	0.1	GO:0070402	NADPH binding(GO:0070402)
0.0	0.0	GO:0004366	glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
0.0	0.2	GO:0043015	gamma-tubulin binding(GO:0043015)
0.0	0.0	GO:0008384	IkappaB kinase activity(GO:0008384)
0.0	0.0	GO:0042156	obsolete zinc-mediated transcriptional activator activity(GO:0042156)
0.0	0.1	GO:0045294	alpha-catenin binding(GO:0045294)
0.0	0.1	GO:0070742	C2H2 zinc finger domain binding(GO:0070742)
0.0	0.1	GO:0008191	metalloendopeptidase inhibitor activity(GO:0008191)
0.0	0.0	GO:0016362	activin receptor activity, type II(GO:0016362)
0.0	0.1	GO:0047238	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.0	0.1	GO:0004176	ATP-dependent peptidase activity(GO:0004176)
0.0	0.1	GO:0004448	isocitrate dehydrogenase activity(GO:0004448)
0.0	0.2	GO:0043498	obsolete cell surface binding(GO:0043498)
0.0	0.1	GO:0042171	1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) lysophosphatidic acid acyltransferase activity(GO:0042171) lysophospholipid acyltransferase activity(GO:0071617)
0.0	0.0	GO:0016854	racemase and epimerase activity(GO:0016854)
0.0	0.0	GO:0030354	melanin-concentrating hormone activity(GO:0030354)
0.0	0.0	GO:0034056	estrogen response element binding(GO:0034056)
0.0	0.0	GO:0032450	maltose alpha-glucosidase activity(GO:0032450)
0.0	0.0	GO:0031685	adenosine receptor binding(GO:0031685)
0.0	0.0	GO:0071723	lipopeptide binding(GO:0071723)
0.0	0.2	GO:0070888	E-box binding(GO:0070888)
0.0	0.0	GO:0016454	serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0	0.1	GO:0004659	prenyltransferase activity(GO:0004659)
0.0	0.3	GO:0008373	sialyltransferase activity(GO:0008373)
0.0	0.1	GO:0017176	phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0	0.0	GO:0035184	histone threonine kinase activity(GO:0035184)
0.0	0.0	GO:0004948	calcitonin receptor activity(GO:0004948)
0.0	0.1	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0	0.0	GO:0042608	T cell receptor binding(GO:0042608)
0.0	0.0	GO:0031177	phosphopantetheine binding(GO:0031177)
0.0	0.1	GO:0008242	omega peptidase activity(GO:0008242)
0.0	0.0	GO:0033300	dehydroascorbic acid transporter activity(GO:0033300)
0.0	0.0	GO:0004596	peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0	0.1	GO:0016889	endodeoxyribonuclease activity, producing 3'-phosphomonoesters(GO:0016889)
0.0	0.1	GO:0051635	obsolete bacterial cell surface binding(GO:0051635)
0.0	0.0	GO:0035173	histone kinase activity(GO:0035173)
0.0	0.2	GO:0005242	inward rectifier potassium channel activity(GO:0005242)
0.0	0.1	GO:0016671	oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor(GO:0016671)
0.0	0.1	GO:0003796	lysozyme activity(GO:0003796)
0.0	0.1	GO:0035240	dopamine binding(GO:0035240)
0.0	0.1	GO:0042834	peptidoglycan binding(GO:0042834)
0.0	0.0	GO:0047623	AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0	0.1	GO:0003993	acid phosphatase activity(GO:0003993)
0.0	0.1	GO:0016634	oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
0.0	0.0	GO:0043024	ribosomal small subunit binding(GO:0043024)
0.0	0.0	GO:0090482	vitamin transmembrane transporter activity(GO:0090482)
0.0	0.0	GO:0005275	amine transmembrane transporter activity(GO:0005275)
0.0	0.1	GO:0030976	thiamine pyrophosphate binding(GO:0030976)
0.0	0.0	GO:0080025	phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0	0.1	GO:0070696	transmembrane receptor protein serine/threonine kinase binding(GO:0070696)
0.0	0.2	GO:1905030	voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.0	0.0	GO:0035252	UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285)
0.0	0.0	GO:0048027	mRNA 5'-UTR binding(GO:0048027)
0.0	0.0	GO:0035197	siRNA binding(GO:0035197)
0.0	0.0	GO:0042289	MHC class II protein binding(GO:0042289)
0.0	0.1	GO:0004550	nucleoside diphosphate kinase activity(GO:0004550)
0.0	0.1	GO:0030306	ADP-ribosylation factor binding(GO:0030306)
0.0	0.1	GO:0004383	guanylate cyclase activity(GO:0004383)
0.0	0.1	GO:0004568	chitinase activity(GO:0004568)
0.0	0.1	GO:0004185	serine-type carboxypeptidase activity(GO:0004185)
0.0	0.1	GO:0004826	phenylalanine-tRNA ligase activity(GO:0004826)
0.0	0.1	GO:0005110	frizzled-2 binding(GO:0005110)
0.0	0.1	GO:0034235	GPI anchor binding(GO:0034235)
0.0	0.0	GO:0033612	receptor serine/threonine kinase binding(GO:0033612)
0.0	0.0	GO:0050265	RNA uridylyltransferase activity(GO:0050265)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.2	PID IL8 CXCR1 PATHWAY	IL8- and CXCR1-mediated signaling events
0.1	PID INTEGRIN A4B1 PATHWAY	Alpha4 beta1 integrin signaling events
0.3	ST PAC1 RECEPTOR PATHWAY	PAC1 Receptor Pathway
0.1	ST INTERFERON GAMMA PATHWAY	Interferon gamma pathway.
0.2	PID IFNG PATHWAY	IFN-gamma pathway
0.2	PID CXCR4 PATHWAY	CXCR4-mediated signaling events
0.1	PID AVB3 INTEGRIN PATHWAY	Integrins in angiogenesis
1.0	PID IL8 CXCR2 PATHWAY	IL8- and CXCR2-mediated signaling events
0.0	PID ARF6 DOWNSTREAM PATHWAY	Arf6 downstream pathway
0.2	PID IL3 PATHWAY	IL3-mediated signaling events
0.1	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.1	PID IL6 7 PATHWAY	IL6-mediated signaling events
0.4	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.2	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1	PID THROMBIN PAR1 PATHWAY	PAR1-mediated thrombin signaling events
0.0	SIG IL4RECEPTOR IN B LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes
0.1	PID ANGIOPOIETIN RECEPTOR PATHWAY	Angiopoietin receptor Tie2-mediated signaling
0.5	SIG PIP3 SIGNALING IN B LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes
0.0	PID AMB2 NEUTROPHILS PATHWAY	amb2 Integrin signaling
0.0	PID ER NONGENOMIC PATHWAY	Plasma membrane estrogen receptor signaling
0.5	PID HDAC CLASSII PATHWAY	Signaling events mediated by HDAC Class II
0.3	PID S1P S1P2 PATHWAY	S1P2 pathway
0.3	PID CONE PATHWAY	Visual signal transduction: Cones
0.1	SA B CELL RECEPTOR COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.1	PID IL1 PATHWAY	IL1-mediated signaling events
0.1	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.3	PID P38 MKK3 6PATHWAY	p38 MAPK signaling pathway
0.2	PID ANTHRAX PATHWAY	Cellular roles of Anthrax toxin
0.0	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0	PID VEGFR1 2 PATHWAY	Signaling events mediated by VEGFR1 and VEGFR2
0.0	PID IGF1 PATHWAY	IGF1 pathway
0.3	PID P38 ALPHA BETA DOWNSTREAM PATHWAY	Signaling mediated by p38-alpha and p38-beta
0.2	PID TCR CALCIUM PATHWAY	Calcium signaling in the CD4+ TCR pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	0.3	REACTOME HOST INTERACTIONS OF HIV FACTORS	Genes involved in Host Interactions of HIV factors
0.1	0.1	REACTOME OPIOID SIGNALLING	Genes involved in Opioid Signalling
0.0	0.5	REACTOME ROLE OF DCC IN REGULATING APOPTOSIS	Genes involved in Role of DCC in regulating apoptosis
0.0	0.4	REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0	0.0	REACTOME GAB1 SIGNALOSOME	Genes involved in GAB1 signalosome
0.0	0.8	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.0	0.0	REACTOME G ALPHA1213 SIGNALLING EVENTS	Genes involved in G alpha (12/13) signalling events
0.0	0.4	REACTOME TRYPTOPHAN CATABOLISM	Genes involved in Tryptophan catabolism
0.0	0.2	REACTOME ERKS ARE INACTIVATED	Genes involved in ERKs are inactivated
0.0	0.3	REACTOME IRAK1 RECRUITS IKK COMPLEX	Genes involved in IRAK1 recruits IKK complex
0.0	0.1	REACTOME GROWTH HORMONE RECEPTOR SIGNALING	Genes involved in Growth hormone receptor signaling
0.0	0.2	REACTOME G PROTEIN BETA GAMMA SIGNALLING	Genes involved in G-protein beta:gamma signalling
0.0	0.7	REACTOME SIGNAL AMPLIFICATION	Genes involved in Signal amplification
0.0	0.3	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
0.0	0.0	REACTOME ACYL CHAIN REMODELLING OF PC	Genes involved in Acyl chain remodelling of PC
0.0	0.1	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.0	0.3	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0	0.2	REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK	Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0	0.2	REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE	Genes involved in Synthesis of PIPs at the late endosome membrane
0.0	0.4	REACTOME PEROXISOMAL LIPID METABOLISM	Genes involved in Peroxisomal lipid metabolism
0.0	0.3	REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS	Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0	0.0	REACTOME SPRY REGULATION OF FGF SIGNALING	Genes involved in Spry regulation of FGF signaling
0.0	0.1	REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL	Genes involved in Cell surface interactions at the vascular wall
0.0	0.4	REACTOME CYTOSOLIC TRNA AMINOACYLATION	Genes involved in Cytosolic tRNA aminoacylation
0.0	0.2	REACTOME THE NLRP3 INFLAMMASOME	Genes involved in The NLRP3 inflammasome
0.0	0.0	REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING	Genes involved in Transferrin endocytosis and recycling
0.0	0.2	REACTOME PASSIVE TRANSPORT BY AQUAPORINS	Genes involved in Passive Transport by Aquaporins
0.0	0.2	REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION	Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0	0.3	REACTOME INWARDLY RECTIFYING K CHANNELS	Genes involved in Inwardly rectifying K+ channels
0.0	0.4	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.0	0.1	REACTOME CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION	Genes involved in Cyclin E associated events during G1/S transition
0.0	0.7	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.0	0.0	REACTOME ACYL CHAIN REMODELLING OF PI	Genes involved in Acyl chain remodelling of PI
0.0	0.2	REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR	Genes involved in Trafficking and processing of endosomal TLR
0.0	0.1	REACTOME ABACAVIR TRANSPORT AND METABOLISM	Genes involved in Abacavir transport and metabolism
0.0	0.3	REACTOME AMINE LIGAND BINDING RECEPTORS	Genes involved in Amine ligand-binding receptors
0.0	0.1	REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION	Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0	0.1	REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS	Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0	0.6	REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS	Genes involved in Golgi Associated Vesicle Biogenesis
0.0	0.1	REACTOME GLYCOPROTEIN HORMONES	Genes involved in Glycoprotein hormones
0.0	0.2	REACTOME SYNTHESIS OF PA	Genes involved in Synthesis of PA
0.0	0.3	REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC	Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.0	0.0	REACTOME TRIGLYCERIDE BIOSYNTHESIS	Genes involved in Triglyceride Biosynthesis
0.0	0.8	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
0.0	0.1	REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION	Genes involved in Apoptosis induced DNA fragmentation
0.0	0.0	REACTOME ACYL CHAIN REMODELLING OF PG	Genes involved in Acyl chain remodelling of PG
0.0	0.1	REACTOME RECYCLING OF BILE ACIDS AND SALTS	Genes involved in Recycling of bile acids and salts
0.0	0.1	REACTOME HORMONE LIGAND BINDING RECEPTORS	Genes involved in Hormone ligand-binding receptors
0.0	0.1	REACTOME COMMON PATHWAY	Genes involved in Common Pathway
0.0	0.2	REACTOME ACYL CHAIN REMODELLING OF PE	Genes involved in Acyl chain remodelling of PE
0.0	1.4	REACTOME G ALPHA I SIGNALLING EVENTS	Genes involved in G alpha (i) signalling events
0.0	0.2	REACTOME N GLYCAN ANTENNAE ELONGATION	Genes involved in N-Glycan antennae elongation
0.0	0.3	REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS	Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.0	0.3	REACTOME ION TRANSPORT BY P TYPE ATPASES	Genes involved in Ion transport by P-type ATPases
0.0	0.5	REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES	Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0	0.2	REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT	Genes involved in Chylomicron-mediated lipid transport
0.0	0.1	REACTOME TRANSPORT OF ORGANIC ANIONS	Genes involved in Transport of organic anions