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ENCODE: H3K4me1 ChIP-Seq of primary human cells

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Results for OTX1

Z-value: 1.52

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Transcription factors associated with OTX1

Gene Symbol	Gene ID	Gene Info
OTX1 Ensembl NCBI GeneCards UniProt	ENSG00000115507.5	orthodenticle homeobox 1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
chr2_63285064_63285215	OTX1	7202	0.239393	0.81	7.7e-03	Click!
chr2_63284454_63284605	OTX1	6592	0.242037	0.77	1.4e-02	Click!
chr2_63285363_63285918	OTX1	7703	0.237606	0.75	2.0e-02	Click!
chr2_63286662_63286820	OTX1	8804	0.234483	0.74	2.3e-02	Click!
chr2_63276937_63277124	OTX1	162	0.937363	0.72	2.7e-02	Click!

Activity of the OTX1 motif across conditions

Conditions sorted by the z-value of the OTX1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chrX_77578325_77578530	0.60	CYSLTR1	cysteinyl leukotriene receptor 1	4553	0.35
chr17_71589775_71590041	0.59	RP11-277J6.2		47257	0.14
chr3_16355269_16355595	0.54	RP11-415F23.2		514	0.77
chr19_30472030_30472181	0.53	URI1	URI1, prefoldin-like chaperone	10105	0.31
chr4_109031503_109031852	0.52	LEF1	lymphoid enhancer-binding factor 1	55780	0.13
chr3_13388775_13388976	0.49	NUP210	nucleoporin 210kDa	72934	0.11
chr8_128989307_128989493	0.48	ENSG00000221771	.	16521	0.16
chr7_50426534_50426685	0.47	IKZF1	IKAROS family zinc finger 1 (Ikaros)	59364	0.13
chr18_29623121_29623509	0.47	ENSG00000265063	.	17637	0.13
chr4_143619137_143619288	0.46	INPP4B	inositol polyphosphate-4-phosphatase, type II, 105kDa	137390	0.05
chr3_69113784_69113935	0.46	TMF1	TATA element modulatory factor 1	12375	0.13
chrX_70321837_70321988	0.45	CXorf65	chromosome X open reading frame 65	4543	0.12
chr1_168490958_168491381	0.45	XCL2	chemokine (C motif) ligand 2	22066	0.23
chr3_73014643_73014836	0.45	GXYLT2	glucoside xylosyltransferase 2	10373	0.2
chr17_66235194_66235719	0.44	AMZ2	archaelysin family metallopeptidase 2	8259	0.16
chr17_62980411_62980628	0.44	AMZ2P1	archaelysin family metallopeptidase 2 pseudogene 1	10884	0.15
chr13_42967027_42967422	0.44	AKAP11	A kinase (PRKA) anchor protein 11	120935	0.06
chr11_35144638_35144937	0.44	AL356215.1		5428	0.19
chr18_45437859_45438131	0.44	SMAD2	SMAD family member 2	12018	0.24
chrX_135774515_135774666	0.43	CD40LG	CD40 ligand	44204	0.12
chr2_204596118_204596345	0.43	CD28	CD28 molecule	24815	0.19
chr1_71545897_71546091	0.43	ZRANB2	zinc finger, RAN-binding domain containing 2	700	0.48
chr18_29639731_29640017	0.43	ENSG00000265063	.	1078	0.43
chr19_36101325_36101624	0.43	HAUS5	HAUS augmin-like complex, subunit 5	2198	0.15
chr10_116258251_116258448	0.43	ABLIM1	actin binding LIM protein 1	10597	0.26
chr1_193447478_193447673	0.42	ENSG00000252241	.	253499	0.02
chr9_21558528_21559235	0.42	MIR31HG	MIR31 host gene (non-protein coding)	787	0.64
chr2_68976425_68976789	0.42	ARHGAP25	Rho GTPase activating protein 25	14593	0.24
chr15_55514993_55515430	0.41	RSL24D1	ribosomal L24 domain containing 1	25946	0.18
chr17_20178582_20178828	0.41	ENSG00000252971	.	14865	0.17
chr7_50300607_50300758	0.41	IKZF1	IKAROS family zinc finger 1 (Ikaros)	43642	0.18
chr14_106471839_106472077	0.41	IGHV1-3	immunoglobulin heavy variable 1-3	235	0.74
chr13_52527464_52527703	0.41	ATP7B	ATPase, Cu++ transporting, beta polypeptide	8468	0.22
chr6_157877638_157877932	0.40	ENSG00000266617	.	72379	0.11
chr5_150517774_150517925	0.40	ANXA6	annexin A6	3352	0.26
chr3_59392779_59393077	0.40	C3orf67	chromosome 3 open reading frame 67	357118	0.01
chr21_43842200_43842523	0.40	ENSG00000252619	.	4659	0.15
chr13_24840686_24840890	0.40	SPATA13	spermatogenesis associated 13	4038	0.2
chr1_161904536_161904981	0.40	OLFML2B	olfactomedin-like 2B	50264	0.14
chr12_68575483_68575644	0.40	IFNG	interferon, gamma	22036	0.21
chrX_49148626_49148900	0.39	GAGE10	G antigen 10	11385	0.08
chr6_15421901_15422177	0.39	JARID2	jumonji, AT rich interactive domain 2	20950	0.24
chr11_113944900_113945166	0.39	ENSG00000221112	.	12618	0.2
chr6_112020418_112020739	0.39	FYN	FYN oncogene related to SRC, FGR, YES	20687	0.21
chr11_102175960_102176111	0.39	ENSG00000212466	.	8418	0.18
chr1_92876308_92876612	0.39	ENSG00000242764	.	8218	0.25
chr1_203297729_203297923	0.39	ENSG00000202300	.	9599	0.17
chr20_34077500_34077678	0.38	RP3-477O4.14		1154	0.34
chr17_37956193_37956565	0.38	IKZF3	IKAROS family zinc finger 3 (Aiolos)	21901	0.13
chr9_98776919_98777112	0.37	ERCC6L2	excision repair cross-complementing rodent repair deficiency, complementation group 6-like 2	41896	0.17
chr5_56126261_56126427	0.37	MAP3K1	mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase	14943	0.16
chr13_75870281_75870432	0.37	TBC1D4	TBC1 domain family, member 4	45311	0.17
chr1_65886839_65886990	0.37	LEPR	leptin receptor	511	0.52
chr14_67956006_67956206	0.37	TMEM229B	transmembrane protein 229B	657	0.69
chr11_73691666_73692195	0.37	UCP2	uncoupling protein 2 (mitochondrial, proton carrier)	53	0.97
chr9_5352223_5352380	0.37	RLN1	relaxin 1	12428	0.21
chr6_509432_509583	0.37	RP1-20B11.2		14664	0.28
chrX_44124831_44125014	0.37	EFHC2	EF-hand domain (C-terminal) containing 2	77996	0.11
chr5_156735418_156735569	0.36	CYFIP2	cytoplasmic FMR1 interacting protein 2	2552	0.24
chr19_41807163_41807314	0.36	CCDC97	coiled-coil domain containing 97	8856	0.11
chr11_78002899_78003070	0.36	RP11-452H21.1		32820	0.15
chr12_46364467_46364684	0.36	SCAF11	SR-related CTD-associated factor 11	19773	0.26
chr1_206913351_206913502	0.36	ENSG00000199349	.	8011	0.16
chr12_15697618_15697769	0.36	PTPRO	protein tyrosine phosphatase, receptor type, O	1593	0.52
chr5_37112693_37112953	0.36	NIPBL	Nipped-B homolog (Drosophila)	53818	0.14
chr4_148973362_148973513	0.36	RP11-76G10.1		94185	0.09
chr6_42345837_42346043	0.36	ENSG00000221252	.	34194	0.17
chr17_65438464_65438635	0.36	ENSG00000244610	.	14857	0.13
chr9_92031645_92032185	0.36	SEMA4D	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D	1833	0.43
chr14_61968102_61968253	0.36	RP11-47I22.4		27669	0.17
chr3_98619464_98619615	0.35	DCBLD2	discoidin, CUB and LCCL domain containing 2	476	0.75
chr11_67179855_67180006	0.35	CARNS1	carnosine synthase 1	3219	0.09
chrX_12970579_12970730	0.35	TMSB4X	thymosin beta 4, X-linked	22573	0.18
chr2_74258513_74258824	0.35	TET3	tet methylcytosine dioxygenase 3	14782	0.17
chr2_135437840_135437991	0.35	TMEM163	transmembrane protein 163	38655	0.21
chr15_45030741_45030930	0.35	TRIM69	tripartite motif containing 69	2071	0.27
chr15_87158408_87158697	0.35	RP11-182L7.1		15815	0.3
chr8_81990406_81990557	0.35	PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	33822	0.22
chr8_66854346_66854497	0.35	DNAJC5B	DnaJ (Hsp40) homolog, subfamily C, member 5 beta	79374	0.1
chr5_169703034_169703822	0.35	LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	9097	0.23
chr10_73869748_73870117	0.35	SPOCK2	sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2	21142	0.19
chr3_150458439_150458615	0.35	SIAH2-AS1	SIAH2 antisense RNA 1	21197	0.14
chr5_75745118_75745695	0.35	IQGAP2	IQ motif containing GTPase activating protein 2	45157	0.18
chr2_75438200_75438351	0.34	TACR1	tachykinin receptor 1	11449	0.25
chr2_191280417_191280683	0.34	MFSD6	major facilitator superfamily domain containing 6	7469	0.21
chr18_2639431_2639582	0.34	ENSG00000200875	.	10360	0.14
chr6_111521255_111521563	0.34	SLC16A10	solute carrier family 16 (aromatic amino acid transporter), member 10	22994	0.17
chrX_25038113_25038264	0.34	ARX	aristaless related homeobox	4123	0.31
chr14_56614561_56614722	0.34	PELI2	pellino E3 ubiquitin protein ligase family member 2	28814	0.22
chr7_50440859_50441289	0.34	ENSG00000200815	.	62004	0.12
chr8_144938668_144938819	0.34	ENSG00000264144	.	12503	0.09
chr6_194026_194220	0.34	DUSP22	dual specificity phosphatase 22	97507	0.09
chr5_139792182_139792333	0.34	ANKHD1	ankyrin repeat and KH domain containing 1	10751	0.11
chr7_50362495_50362678	0.34	IKZF1	IKAROS family zinc finger 1 (Ikaros)	4659	0.32
chr3_108551517_108551700	0.34	TRAT1	T cell receptor associated transmembrane adaptor 1	9989	0.26
chr13_74860376_74860556	0.34	ENSG00000206617	.	2885	0.39
chr21_16887561_16887770	0.33	ENSG00000212564	.	98937	0.08
chr9_33026322_33026547	0.33	DNAJA1	DnaJ (Hsp40) homolog, subfamily A, member 1	1161	0.45
chr5_140800694_140800866	0.33	PCDHGA11	protocadherin gamma subfamily A, 11	15	0.92
chr10_124300753_124301107	0.33	DMBT1	deleted in malignant brain tumors 1	19251	0.2
chr4_6174725_6175042	0.33	JAKMIP1	janus kinase and microtubule interacting protein 1	21461	0.25
chr19_5971655_5971871	0.33	RANBP3	RAN binding protein 3	6327	0.12
chr7_114645798_114646091	0.33	MDFIC	MyoD family inhibitor domain containing	72020	0.13
chr1_29245607_29245758	0.33	EPB41	erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)	4591	0.21
chr2_68379385_68379654	0.33	WDR92	WD repeat domain 92	5086	0.18
chr11_73702815_73702966	0.33	UCP2	uncoupling protein 2 (mitochondrial, proton carrier)	8538	0.14
chr12_54675160_54675465	0.33	HNRNPA1	heterogeneous nuclear ribonucleoprotein A1	342	0.7
chr1_100863756_100864116	0.33	ENSG00000216067	.	19605	0.19
chr14_65395685_65395897	0.33	CHURC1-FNTB	CHURC1-FNTB readthrough	5037	0.12
chr5_85334298_85334449	0.33	NBPF22P	neuroblastoma breakpoint family, member 22, pseudogene	244211	0.02
chr15_45001470_45001621	0.33	B2M	beta-2-microglobulin	2130	0.24
chr7_12297969_12298124	0.33	TMEM106B	transmembrane protein 106B	47097	0.19
chr3_18470958_18471238	0.33	SATB1	SATB homeobox 1	4237	0.24
chr7_13950051_13950250	0.32	ETV1	ets variant 1	75916	0.12
chr3_33091306_33091488	0.32	GLB1	galactosidase, beta 1	46887	0.11
chr3_98277242_98277459	0.32	GPR15	G protein-coupled receptor 15	26607	0.12
chr10_1168832_1168983	0.32	WDR37	WD repeat domain 37	48584	0.12
chr2_191925730_191925888	0.32	ENSG00000231858	.	39557	0.13
chr11_66393466_66393617	0.32	RBM14	RNA binding motif protein 14	9355	0.09
chr12_104896776_104896927	0.32	CHST11	carbohydrate (chondroitin 4) sulfotransferase 11	46072	0.17
chr21_43658115_43658266	0.32	ENSG00000223262	.	16907	0.16
chr11_75219570_75220088	0.32	RP11-939C17.4		393	0.82
chr1_154912617_154913094	0.31	PMVK	phosphomevalonate kinase	3388	0.11
chr7_55584165_55584331	0.31	VOPP1	vesicular, overexpressed in cancer, prosurvival protein 1	478	0.86
chr16_18811637_18811837	0.31	ARL6IP1	ADP-ribosylation factor-like 6 interacting protein 1	1009	0.33
chr15_38545893_38546208	0.31	SPRED1	sprouty-related, EVH1 domain containing 1	668	0.83
chrX_19786390_19786617	0.31	SH3KBP1	SH3-domain kinase binding protein 1	20682	0.27
chr7_35687826_35688061	0.31	HERPUD2	HERPUD family member 2	46233	0.16
chr15_75136605_75137116	0.31	ULK3	unc-51 like kinase 3	1322	0.29
chr10_112483545_112483823	0.31	ENSG00000252036	.	32530	0.14
chr3_71437386_71437590	0.31	FOXP1	forkhead box P1	83577	0.1
chr17_33865226_33865568	0.31	SLFN12L	schlafen family member 12-like	517	0.66
chr5_156994069_156994363	0.31	AC106801.1		1244	0.41
chr1_192484853_192485075	0.31	ENSG00000221145	.	24614	0.2
chrX_3605354_3605505	0.31	PRKX	protein kinase, X-linked	26220	0.16
chr3_195250615_195250766	0.31	ENSG00000252620	.	671	0.67
chr20_57735088_57735478	0.31	ZNF831	zinc finger protein 831	30792	0.19
chr12_102453949_102454100	0.31	CCDC53	coiled-coil domain containing 53	1833	0.31
chr16_75661496_75661713	0.31	ADAT1	adenosine deaminase, tRNA-specific 1	4406	0.16
chr2_135080063_135080349	0.31	MGAT5	mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase	68376	0.13
chr7_140571114_140571265	0.31	ENSG00000271932	.	12683	0.23
chr4_40305683_40306008	0.31	CHRNA9	cholinergic receptor, nicotinic, alpha 9 (neuronal)	31501	0.18
chr3_56769543_56769694	0.31	ARHGEF3	Rho guanine nucleotide exchange factor (GEF) 3	39977	0.18
chr15_60871500_60871746	0.31	RORA	RAR-related orphan receptor A	13117	0.21
chrX_119889254_119889658	0.31	CT47B1	cancer/testis antigen family 47, member B1	120323	0.04
chr2_216948536_216948711	0.30	TMEM169	transmembrane protein 169	1981	0.27
chr1_160592657_160592947	0.30	SLAMF1	signaling lymphocytic activation molecule family member 1	24009	0.13
chr16_3859769_3859931	0.30	CREBBP	CREB binding protein	28982	0.18
chr6_37467874_37468104	0.30	CCDC167	coiled-coil domain containing 167	291	0.92
chr8_66843360_66843705	0.30	PDE7A	phosphodiesterase 7A	89345	0.09
chr10_8102007_8102158	0.30	GATA3	GATA binding protein 3	5313	0.35
chr8_52810108_52810331	0.30	RP11-110G21.2		1285	0.3
chr13_48809086_48809237	0.30	ITM2B	integral membrane protein 2B	1822	0.45
chr4_40213832_40214143	0.30	RHOH	ras homolog family member H	12023	0.22
chr14_98871416_98871598	0.30	ENSG00000241757	.	53506	0.16
chr1_8488032_8488525	0.30	RP5-1115A15.1		2580	0.27
chr6_52261106_52261257	0.30	EFHC1	EF-hand domain (C-terminal) containing 1	23925	0.19
chr11_95940247_95940453	0.30	ENSG00000266192	.	134252	0.05
chr2_204398755_204399117	0.30	RAPH1	Ras association (RalGDS/AF-6) and pleckstrin homology domains 1	780	0.77
chr4_40216111_40216289	0.29	RHOH	ras homolog family member H	14236	0.21
chr8_125656871_125657085	0.29	RP11-532M24.1		65106	0.1
chr14_50406726_50407219	0.29	ENSG00000251929	.	38304	0.11
chr1_89994823_89994991	0.29	LRRC8B	leucine rich repeat containing 8 family, member B	4445	0.28
chr12_55373549_55373788	0.29	TESPA1	thymocyte expressed, positive selection associated 1	1954	0.39
chr22_40644279_40644430	0.29	TNRC6B	trinucleotide repeat containing 6B	16653	0.23
chr7_138731189_138731354	0.29	ZC3HAV1L	zinc finger CCCH-type, antiviral 1-like	10496	0.21
chr10_63870514_63870665	0.29	ENSG00000221094	.	5385	0.29
chr17_76709505_76709686	0.29	CYTH1	cytohesin 1	3512	0.24
chr7_33087595_33087805	0.29	ENSG00000241420	.	1998	0.27
chr17_1773103_1773254	0.29	RPA1	replication protein A1, 70kDa	9151	0.15
chr18_60979198_60979416	0.29	RP11-28F1.2		2008	0.3
chrX_40588576_40588727	0.29	MED14-AS1	MED14 antisense RNA 1	6001	0.23
chr7_144215265_144215416	0.29	ENSG00000221507	.	66566	0.11
chr1_66741552_66741903	0.29	PDE4B	phosphodiesterase 4B, cAMP-specific	18397	0.28
chr2_197126192_197126464	0.29	AC020571.3		1171	0.51
chr18_43767825_43767976	0.29	C18orf25	chromosome 18 open reading frame 25	13900	0.21
chr8_117768274_117768425	0.29	EIF3H	eukaryotic translation initiation factor 3, subunit H	288	0.92
chr2_28809993_28810237	0.29	PLB1	phospholipase B1	14671	0.23
chr17_62505406_62505557	0.29	CEP95	centrosomal protein 95kDa	880	0.41
chr5_153651606_153651926	0.29	ENSG00000221070	.	67920	0.09
chr14_64116714_64117321	0.29	ENSG00000200693	.	1200	0.38
chr1_167589694_167589845	0.29	RCSD1	RCSD domain containing 1	9561	0.19
chr15_90479619_90479888	0.29	C15orf38	chromosome 15 open reading frame 38	23565	0.1
chr9_95475297_95475448	0.29	IPPK	inositol 1,3,4,5,6-pentakisphosphate 2-kinase	42825	0.13
chr22_44722175_44722389	0.29	KIAA1644	KIAA1644	13551	0.24
chr3_49453158_49453470	0.29	TCTA	T-cell leukemia translocation altered	3675	0.11
chr5_150550351_150550502	0.28	ANXA6	annexin A6	12983	0.19
chr5_80304301_80304452	0.28	CTC-459I6.1		47650	0.15
chr5_154321009_154321226	0.28	MRPL22	mitochondrial ribosomal protein L22	455	0.8
chr12_90272899_90273318	0.28	ENSG00000252823	.	125272	0.06
chr6_122721602_122721753	0.28	HSF2	heat shock transcription factor 2	981	0.66
chr14_75994181_75994458	0.28	BATF	basic leucine zipper transcription factor, ATF-like	5416	0.21
chr6_25032884_25033035	0.28	ENSG00000244618	.	1449	0.4
chr5_118606969_118607129	0.28	TNFAIP8	tumor necrosis factor, alpha-induced protein 8	2600	0.27
chr16_22370083_22370234	0.28	RP11-21M24.3		6284	0.15
chr14_65164719_65164870	0.28	PLEKHG3	pleckstrin homology domain containing, family G (with RhoGef domain) member 3	6026	0.24
chr17_38022245_38022396	0.28	IKZF3	IKAROS family zinc finger 3 (Aiolos)	1879	0.24
chr2_128243399_128243684	0.28	ENSG00000202429	.	13731	0.14
chr20_51596232_51596383	0.28	TSHZ2	teashirt zinc finger homeobox 2	7361	0.29
chr10_6588130_6588351	0.28	PRKCQ	protein kinase C, theta	33961	0.23

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of OTX1

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View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.5	GO:0030854	positive regulation of granulocyte differentiation(GO:0030854)
0.1	0.2	GO:0045066	regulatory T cell differentiation(GO:0045066)
0.1	0.1	GO:0002326	B cell lineage commitment(GO:0002326)
0.1	0.4	GO:0033152	immunoglobulin V(D)J recombination(GO:0033152)
0.1	0.2	GO:0002513	tolerance induction to self antigen(GO:0002513)
0.1	0.4	GO:0045589	regulation of regulatory T cell differentiation(GO:0045589)
0.1	0.5	GO:0048096	chromatin-mediated maintenance of transcription(GO:0048096)
0.1	0.3	GO:0001672	regulation of chromatin assembly or disassembly(GO:0001672)
0.1	0.3	GO:0035405	histone-threonine phosphorylation(GO:0035405)
0.1	0.2	GO:0010040	response to iron(II) ion(GO:0010040)
0.1	0.2	GO:0010957	negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137)
0.1	0.3	GO:0050857	positive regulation of antigen receptor-mediated signaling pathway(GO:0050857)
0.1	0.3	GO:1901339	activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.1	0.1	GO:0042996	regulation of Golgi to plasma membrane protein transport(GO:0042996)
0.1	0.2	GO:0060235	lens induction in camera-type eye(GO:0060235)
0.1	0.2	GO:0043301	negative regulation of myeloid leukocyte mediated immunity(GO:0002887) negative regulation of leukocyte degranulation(GO:0043301)
0.1	0.1	GO:0043619	regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0043619)
0.1	0.3	GO:0002313	mature B cell differentiation involved in immune response(GO:0002313)
0.1	0.2	GO:0018343	protein farnesylation(GO:0018343)
0.1	0.3	GO:0045898	regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.1	0.2	GO:0045722	positive regulation of gluconeogenesis(GO:0045722)
0.1	0.2	GO:0072217	negative regulation of metanephros development(GO:0072217)
0.1	0.4	GO:0035246	peptidyl-arginine N-methylation(GO:0035246)
0.1	0.2	GO:2000351	endothelial cell apoptotic process(GO:0072577) epithelial cell apoptotic process(GO:1904019) regulation of epithelial cell apoptotic process(GO:1904035) regulation of endothelial cell apoptotic process(GO:2000351)
0.1	0.1	GO:0046642	negative regulation of alpha-beta T cell proliferation(GO:0046642)
0.1	0.1	GO:0002677	negative regulation of chronic inflammatory response(GO:0002677)
0.1	0.2	GO:0043320	natural killer cell activation involved in immune response(GO:0002323) natural killer cell degranulation(GO:0043320)
0.1	0.2	GO:0003056	regulation of vascular smooth muscle contraction(GO:0003056)
0.1	0.3	GO:0032876	regulation of DNA endoreduplication(GO:0032875) negative regulation of DNA endoreduplication(GO:0032876) DNA endoreduplication(GO:0042023)
0.1	0.7	GO:0000303	response to superoxide(GO:0000303)
0.1	0.2	GO:0006384	transcription initiation from RNA polymerase III promoter(GO:0006384)
0.1	0.2	GO:0048388	endosomal lumen acidification(GO:0048388)
0.1	0.2	GO:0000154	rRNA modification(GO:0000154)
0.1	0.2	GO:0042685	negative regulation of heart induction by canonical Wnt signaling pathway(GO:0003136) negative regulation of cardioblast cell fate specification(GO:0009997) cardioblast cell fate commitment(GO:0042684) cardioblast cell fate specification(GO:0042685) regulation of cardioblast cell fate specification(GO:0042686) negative regulation of cardioblast differentiation(GO:0051892) cardiac cell fate specification(GO:0060912) negative regulation of heart induction(GO:1901320) negative regulation of cardiocyte differentiation(GO:1905208) regulation of cardiac cell fate specification(GO:2000043) negative regulation of cardiac cell fate specification(GO:2000044)
0.1	0.2	GO:0060999	positive regulation of dendritic spine development(GO:0060999)
0.1	0.2	GO:0003161	cardiac conduction system development(GO:0003161)
0.1	0.2	GO:0070672	response to interleukin-15(GO:0070672)
0.1	0.3	GO:0007256	activation of JNKK activity(GO:0007256)
0.1	0.2	GO:0006104	succinyl-CoA metabolic process(GO:0006104)
0.1	0.1	GO:0046007	negative regulation of activated T cell proliferation(GO:0046007)
0.1	0.2	GO:0060751	branch elongation involved in mammary gland duct branching(GO:0060751)
0.1	0.1	GO:0044413	evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.0	0.2	GO:0015705	iodide transport(GO:0015705)
0.0	0.0	GO:0031935	regulation of chromatin silencing(GO:0031935) negative regulation of chromatin silencing(GO:0031936)
0.0	0.3	GO:0002063	chondrocyte development(GO:0002063)
0.0	0.1	GO:0036072	intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.0	0.2	GO:0035434	copper ion transmembrane transport(GO:0035434)
0.0	0.2	GO:0007008	outer mitochondrial membrane organization(GO:0007008) protein import into mitochondrial outer membrane(GO:0045040)
0.0	0.3	GO:0002507	tolerance induction(GO:0002507)
0.0	0.1	GO:0018076	N-terminal peptidyl-lysine acetylation(GO:0018076)
0.0	0.0	GO:0002710	negative regulation of T cell mediated immunity(GO:0002710)
0.0	0.1	GO:0070932	histone H3 deacetylation(GO:0070932) histone H4 deacetylation(GO:0070933)
0.0	0.2	GO:0046398	UDP-glucuronate metabolic process(GO:0046398)
0.0	0.1	GO:0046476	glycosylceramide biosynthetic process(GO:0046476)
0.0	0.0	GO:0002890	negative regulation of B cell mediated immunity(GO:0002713) negative regulation of immunoglobulin mediated immune response(GO:0002890)
0.0	0.2	GO:0034755	iron ion transmembrane transport(GO:0034755)
0.0	0.3	GO:0033169	histone H3-K9 demethylation(GO:0033169)
0.0	0.2	GO:0009051	pentose-phosphate shunt, oxidative branch(GO:0009051)
0.0	0.3	GO:0050858	negative regulation of antigen receptor-mediated signaling pathway(GO:0050858) negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0	0.1	GO:0047484	regulation of response to osmotic stress(GO:0047484)
0.0	0.0	GO:0061154	endothelial tube morphogenesis(GO:0061154)
0.0	0.3	GO:0051489	regulation of filopodium assembly(GO:0051489)
0.0	0.3	GO:0045116	protein neddylation(GO:0045116)
0.0	0.2	GO:0006924	activation-induced cell death of T cells(GO:0006924)
0.0	0.2	GO:0034086	maintenance of sister chromatid cohesion(GO:0034086) maintenance of mitotic sister chromatid cohesion(GO:0034088)
0.0	0.2	GO:0045349	interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354)
0.0	0.2	GO:0032075	positive regulation of nuclease activity(GO:0032075)
0.0	0.4	GO:0043368	positive T cell selection(GO:0043368)
0.0	0.1	GO:0015801	aromatic amino acid transport(GO:0015801)
0.0	0.6	GO:0006376	mRNA splice site selection(GO:0006376)
0.0	0.1	GO:0010447	response to acidic pH(GO:0010447)
0.0	0.1	GO:1903077	negative regulation of establishment of protein localization to plasma membrane(GO:0090005) negative regulation of protein localization to plasma membrane(GO:1903077) negative regulation of protein localization to cell periphery(GO:1904376)
0.0	0.1	GO:0032803	regulation of low-density lipoprotein particle receptor catabolic process(GO:0032803) regulation of receptor catabolic process(GO:2000644)
0.0	0.1	GO:0046101	hypoxanthine biosynthetic process(GO:0046101)
0.0	0.1	GO:0001714	endodermal cell fate specification(GO:0001714) regulation of endodermal cell fate specification(GO:0042663) regulation of endodermal cell differentiation(GO:1903224)
0.0	0.0	GO:0034122	negative regulation of toll-like receptor signaling pathway(GO:0034122)
0.0	0.2	GO:0060040	retinal bipolar neuron differentiation(GO:0060040)
0.0	1.0	GO:0050690	regulation of defense response to virus by virus(GO:0050690)
0.0	0.2	GO:0045793	positive regulation of cell size(GO:0045793)
0.0	0.1	GO:0090047	obsolete positive regulation of transcription regulator activity(GO:0090047)
0.0	0.2	GO:0043984	histone H4-K16 acetylation(GO:0043984)
0.0	0.2	GO:0071480	cellular response to gamma radiation(GO:0071480)
0.0	0.0	GO:0002839	regulation of response to tumor cell(GO:0002834) positive regulation of response to tumor cell(GO:0002836) regulation of immune response to tumor cell(GO:0002837) positive regulation of immune response to tumor cell(GO:0002839)
0.0	0.1	GO:0035455	response to interferon-alpha(GO:0035455)
0.0	0.1	GO:0071364	cellular response to epidermal growth factor stimulus(GO:0071364)
0.0	0.1	GO:0003323	type B pancreatic cell development(GO:0003323)
0.0	0.0	GO:0060677	ureteric bud elongation(GO:0060677)
0.0	0.2	GO:0031061	negative regulation of histone methylation(GO:0031061)
0.0	0.2	GO:0006198	cAMP catabolic process(GO:0006198)
0.0	0.2	GO:0048013	ephrin receptor signaling pathway(GO:0048013)
0.0	0.2	GO:0042989	sequestering of actin monomers(GO:0042989)
0.0	0.1	GO:0007352	zygotic specification of dorsal/ventral axis(GO:0007352)
0.0	0.1	GO:0015917	aminophospholipid transport(GO:0015917)
0.0	0.1	GO:0009106	lipoate metabolic process(GO:0009106)
0.0	0.1	GO:0031297	replication fork processing(GO:0031297)
0.0	0.1	GO:0006167	AMP biosynthetic process(GO:0006167)
0.0	0.1	GO:0010508	positive regulation of autophagy(GO:0010508)
0.0	0.1	GO:0009048	dosage compensation by inactivation of X chromosome(GO:0009048)
0.0	0.2	GO:0034314	Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.0	0.1	GO:0051665	membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580) membrane raft localization(GO:0051665)
0.0	0.1	GO:0021819	cerebral cortex radial glia guided migration(GO:0021801) layer formation in cerebral cortex(GO:0021819) telencephalon glial cell migration(GO:0022030)
0.0	0.1	GO:0014742	positive regulation of cardiac muscle hypertrophy(GO:0010613) positive regulation of muscle hypertrophy(GO:0014742)
0.0	0.2	GO:0070934	CRD-mediated mRNA stabilization(GO:0070934)
0.0	0.1	GO:0016081	synaptic vesicle docking(GO:0016081)
0.0	0.1	GO:0021894	interneuron migration from the subpallium to the cortex(GO:0021830) cerebral cortex GABAergic interneuron migration(GO:0021853) cerebral cortex GABAergic interneuron development(GO:0021894) interneuron migration(GO:1904936)
0.0	0.1	GO:0071166	ribonucleoprotein complex localization(GO:0071166)
0.0	0.1	GO:0017182	peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.0	0.0	GO:2000144	positive regulation of transcription initiation from RNA polymerase II promoter(GO:0060261) positive regulation of DNA-templated transcription, initiation(GO:2000144)
0.0	0.0	GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway(GO:0007195)
0.0	0.1	GO:0006556	S-adenosylmethionine biosynthetic process(GO:0006556)
0.0	0.0	GO:0002335	mature B cell differentiation(GO:0002335)
0.0	0.1	GO:0034063	stress granule assembly(GO:0034063)
0.0	0.1	GO:0003351	epithelial cilium movement(GO:0003351) epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
0.0	0.1	GO:0019730	antimicrobial humoral response(GO:0019730) antibacterial humoral response(GO:0019731)
0.0	0.1	GO:0008089	anterograde axonal transport(GO:0008089)
0.0	0.0	GO:0002085	inhibition of neuroepithelial cell differentiation(GO:0002085)
0.0	0.1	GO:0007021	tubulin complex assembly(GO:0007021)
0.0	0.1	GO:0016242	regulation of macroautophagy(GO:0016241) negative regulation of macroautophagy(GO:0016242)
0.0	0.2	GO:0042994	cytoplasmic sequestering of transcription factor(GO:0042994)
0.0	0.1	GO:0034139	regulation of toll-like receptor 3 signaling pathway(GO:0034139)
0.0	0.0	GO:0039656	modulation by virus of host gene expression(GO:0039656)
0.0	0.0	GO:0007100	mitotic centrosome separation(GO:0007100)
0.0	0.2	GO:0072273	metanephric nephron morphogenesis(GO:0072273)
0.0	0.1	GO:0051409	response to nitrosative stress(GO:0051409)
0.0	0.1	GO:0051583	dopamine uptake involved in synaptic transmission(GO:0051583) catecholamine uptake involved in synaptic transmission(GO:0051934) catecholamine uptake(GO:0090493) dopamine uptake(GO:0090494)
0.0	0.1	GO:0036473	intrinsic apoptotic signaling pathway in response to oxidative stress(GO:0008631) cell death in response to oxidative stress(GO:0036473)
0.0	0.1	GO:0035025	positive regulation of Rho protein signal transduction(GO:0035025)
0.0	0.1	GO:0018342	protein prenylation(GO:0018342) prenylation(GO:0097354)
0.0	0.1	GO:0090206	negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206)
0.0	0.0	GO:0051541	elastin metabolic process(GO:0051541)
0.0	0.2	GO:0042769	DNA damage response, detection of DNA damage(GO:0042769)
0.0	0.4	GO:0016578	histone deubiquitination(GO:0016578)
0.0	0.1	GO:0002862	negative regulation of inflammatory response to antigenic stimulus(GO:0002862)
0.0	0.0	GO:1903312	negative regulation of mRNA processing(GO:0050686) negative regulation of mRNA metabolic process(GO:1903312)
0.0	0.1	GO:0072393	microtubule anchoring at microtubule organizing center(GO:0072393)
0.0	0.2	GO:0006390	mitochondrial RNA metabolic process(GO:0000959) transcription from mitochondrial promoter(GO:0006390)
0.0	0.1	GO:0019987	obsolete negative regulation of anti-apoptosis(GO:0019987)
0.0	0.1	GO:0036465	synaptic vesicle recycling(GO:0036465) synaptic vesicle endocytosis(GO:0048488) clathrin-mediated endocytosis(GO:0072583)
0.0	0.1	GO:0060157	urinary bladder development(GO:0060157)
0.0	0.2	GO:0045071	negative regulation of viral genome replication(GO:0045071)
0.0	0.1	GO:0090205	positive regulation of cholesterol metabolic process(GO:0090205)
0.0	0.3	GO:0021516	dorsal spinal cord development(GO:0021516)
0.0	0.2	GO:0006030	chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.0	0.5	GO:0006891	intra-Golgi vesicle-mediated transport(GO:0006891)
0.0	0.1	GO:0031442	regulation of mRNA 3'-end processing(GO:0031440) positive regulation of mRNA 3'-end processing(GO:0031442) positive regulation of mRNA processing(GO:0050685) positive regulation of mRNA metabolic process(GO:1903313)
0.0	0.2	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0	0.0	GO:0032713	negative regulation of interleukin-4 production(GO:0032713)
0.0	0.6	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.0	0.1	GO:0045061	thymic T cell selection(GO:0045061)
0.0	0.2	GO:0006491	N-glycan processing(GO:0006491)
0.0	0.1	GO:0032486	Rap protein signal transduction(GO:0032486)
0.0	0.0	GO:0070777	D-amino acid transport(GO:0042940) D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0	0.4	GO:0007052	mitotic spindle organization(GO:0007052)
0.0	0.0	GO:0009299	mRNA transcription(GO:0009299)
0.0	0.1	GO:0032212	positive regulation of telomere maintenance via telomerase(GO:0032212) positive regulation of telomere maintenance via telomere lengthening(GO:1904358)
0.0	0.0	GO:0042091	interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.0	0.1	GO:0045292	mRNA cis splicing, via spliceosome(GO:0045292)
0.0	0.1	GO:0006610	ribosomal protein import into nucleus(GO:0006610)
0.0	0.2	GO:0071108	protein K48-linked deubiquitination(GO:0071108)
0.0	0.2	GO:0007016	cytoskeletal anchoring at plasma membrane(GO:0007016)
0.0	0.0	GO:0061030	epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.0	0.1	GO:0045540	regulation of cholesterol biosynthetic process(GO:0045540)
0.0	0.2	GO:0043508	negative regulation of JUN kinase activity(GO:0043508)
0.0	0.0	GO:0046548	retinal rod cell development(GO:0046548)
0.0	0.0	GO:0048539	bone marrow development(GO:0048539)
0.0	0.1	GO:0000394	RNA splicing, via endonucleolytic cleavage and ligation(GO:0000394) tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.0	0.1	GO:0019255	glucose 1-phosphate metabolic process(GO:0019255)
0.0	0.2	GO:0042130	negative regulation of T cell proliferation(GO:0042130)
0.0	0.0	GO:0042159	lipoprotein catabolic process(GO:0042159)
0.0	0.2	GO:0006688	glycosphingolipid biosynthetic process(GO:0006688)
0.0	0.2	GO:0031648	protein destabilization(GO:0031648)
0.0	0.0	GO:0090009	primitive streak formation(GO:0090009)
0.0	0.0	GO:0061298	retina vasculature development in camera-type eye(GO:0061298) retina vasculature morphogenesis in camera-type eye(GO:0061299)
0.0	0.2	GO:0007007	inner mitochondrial membrane organization(GO:0007007)
0.0	0.0	GO:0070208	protein heterotrimerization(GO:0070208)
0.0	0.0	GO:0033622	integrin activation(GO:0033622)
0.0	0.0	GO:0043247	telomere capping(GO:0016233) protection from non-homologous end joining at telomere(GO:0031848) telomere maintenance in response to DNA damage(GO:0043247)
0.0	0.1	GO:0033687	osteoblast proliferation(GO:0033687)
0.0	0.3	GO:0007379	segment specification(GO:0007379)
0.0	0.0	GO:0006562	proline catabolic process(GO:0006562)
0.0	0.1	GO:0016553	base conversion or substitution editing(GO:0016553)
0.0	0.1	GO:0051103	DNA ligation involved in DNA repair(GO:0051103)
0.0	0.1	GO:0000012	single strand break repair(GO:0000012)
0.0	0.1	GO:0006516	glycoprotein catabolic process(GO:0006516)
0.0	0.2	GO:0098927	early endosome to late endosome transport(GO:0045022) vesicle-mediated transport between endosomal compartments(GO:0098927)
0.0	0.1	GO:0090231	regulation of spindle checkpoint(GO:0090231)
0.0	0.1	GO:0006998	nuclear envelope organization(GO:0006998)
0.0	0.1	GO:0070837	dehydroascorbic acid transport(GO:0070837)
0.0	0.0	GO:0001661	conditioned taste aversion(GO:0001661)
0.0	0.2	GO:0032456	endocytic recycling(GO:0032456)
0.0	0.1	GO:0035511	oxidative DNA demethylation(GO:0035511)
0.0	0.1	GO:0045010	actin nucleation(GO:0045010)
0.0	0.1	GO:0014889	muscle atrophy(GO:0014889)
0.0	0.3	GO:0006513	protein monoubiquitination(GO:0006513)
0.0	0.1	GO:0071391	cellular response to estrogen stimulus(GO:0071391)
0.0	0.1	GO:2001021	negative regulation of response to DNA damage stimulus(GO:2001021)
0.0	0.1	GO:0000733	DNA strand renaturation(GO:0000733)
0.0	0.1	GO:0009301	snRNA transcription(GO:0009301)
0.0	0.1	GO:0007172	signal complex assembly(GO:0007172)
0.0	0.0	GO:0048541	Peyer's patch development(GO:0048541)
0.0	0.1	GO:0006855	drug transmembrane transport(GO:0006855)
0.0	0.1	GO:0006089	lactate metabolic process(GO:0006089)
0.0	0.0	GO:0010572	positive regulation of platelet activation(GO:0010572)
0.0	0.1	GO:0015015	heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0	0.1	GO:0006685	sphingomyelin catabolic process(GO:0006685)
0.0	0.0	GO:0051446	positive regulation of meiotic nuclear division(GO:0045836) positive regulation of meiotic cell cycle(GO:0051446)
0.0	0.2	GO:0042273	ribosomal large subunit biogenesis(GO:0042273)
0.0	0.2	GO:0045954	positive regulation of natural killer cell mediated immunity(GO:0002717) positive regulation of natural killer cell mediated cytotoxicity(GO:0045954)
0.0	0.0	GO:0046877	regulation of saliva secretion(GO:0046877)
0.0	0.1	GO:0008356	asymmetric cell division(GO:0008356)
0.0	0.1	GO:0008295	spermidine biosynthetic process(GO:0008295)
0.0	0.0	GO:0048859	formation of anatomical boundary(GO:0048859)
0.0	0.0	GO:0001831	trophectodermal cellular morphogenesis(GO:0001831)
0.0	0.1	GO:0060218	hematopoietic stem cell differentiation(GO:0060218)
0.0	0.1	GO:1903310	positive regulation of chromatin modification(GO:1903310)
0.0	0.1	GO:0006337	nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.0	0.1	GO:0015825	L-serine transport(GO:0015825) serine transport(GO:0032329)
0.0	0.1	GO:0098900	regulation of action potential(GO:0098900)
0.0	0.0	GO:0051533	positive regulation of NFAT protein import into nucleus(GO:0051533)
0.0	0.1	GO:0070198	protein localization to chromosome, telomeric region(GO:0070198)
0.0	0.1	GO:0006422	aspartyl-tRNA aminoacylation(GO:0006422)
0.0	0.2	GO:0051806	entry into host cell(GO:0030260) entry into host(GO:0044409) entry into cell of other organism involved in symbiotic interaction(GO:0051806) entry into other organism involved in symbiotic interaction(GO:0051828)
0.0	0.3	GO:0016254	preassembly of GPI anchor in ER membrane(GO:0016254)
0.0	0.3	GO:0043488	regulation of mRNA stability(GO:0043488)
0.0	0.1	GO:0048261	negative regulation of receptor-mediated endocytosis(GO:0048261)
0.0	0.0	GO:0048865	stem cell fate commitment(GO:0048865) stem cell fate determination(GO:0048867)
0.0	0.0	GO:0003402	planar cell polarity pathway involved in axis elongation(GO:0003402)
0.0	0.1	GO:0016266	O-glycan processing(GO:0016266)
0.0	0.0	GO:0006922	obsolete cleavage of lamin involved in execution phase of apoptosis(GO:0006922)
0.0	0.1	GO:0060325	face morphogenesis(GO:0060325)
0.0	0.1	GO:0046501	protoporphyrinogen IX metabolic process(GO:0046501)
0.0	0.1	GO:1903038	negative regulation of T cell activation(GO:0050868) negative regulation of leukocyte cell-cell adhesion(GO:1903038)
0.0	0.0	GO:0043117	positive regulation of vascular permeability(GO:0043117)
0.0	0.1	GO:0043457	regulation of cellular respiration(GO:0043457)
0.0	0.0	GO:0075713	establishment of viral latency(GO:0019043) establishment of integrated proviral latency(GO:0075713)
0.0	0.1	GO:0018106	peptidyl-histidine phosphorylation(GO:0018106) peptidyl-histidine modification(GO:0018202)
0.0	0.0	GO:0033522	histone H2A ubiquitination(GO:0033522)
0.0	0.1	GO:0006546	glycine catabolic process(GO:0006546)
0.0	0.1	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress(GO:0070059)
0.0	0.0	GO:0051151	negative regulation of smooth muscle cell differentiation(GO:0051151)
0.0	0.0	GO:0006659	phosphatidylserine biosynthetic process(GO:0006659)
0.0	0.1	GO:0000089	mitotic metaphase(GO:0000089)
0.0	0.1	GO:0006983	ER overload response(GO:0006983)
0.0	0.3	GO:0007339	binding of sperm to zona pellucida(GO:0007339)
0.0	0.1	GO:0006474	N-terminal protein amino acid acetylation(GO:0006474)
0.0	0.0	GO:0032753	positive regulation of interleukin-4 production(GO:0032753)
0.0	0.2	GO:0046519	sphingoid metabolic process(GO:0046519)
0.0	0.1	GO:0016188	synaptic vesicle maturation(GO:0016188)
0.0	0.1	GO:0006264	mitochondrial DNA replication(GO:0006264)
0.0	0.0	GO:1901522	positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.0	0.0	GO:0001302	replicative cell aging(GO:0001302)
0.0	0.0	GO:0060084	synaptic transmission involved in micturition(GO:0060084)
0.0	0.0	GO:0003283	atrial septum development(GO:0003283) atrial septum morphogenesis(GO:0060413)
0.0	0.2	GO:0006613	cotranslational protein targeting to membrane(GO:0006613)
0.0	0.0	GO:0008298	intracellular mRNA localization(GO:0008298)
0.0	0.1	GO:0030540	female genitalia development(GO:0030540)
0.0	0.6	GO:0031295	lymphocyte costimulation(GO:0031294) T cell costimulation(GO:0031295)
0.0	0.0	GO:0034214	protein hexamerization(GO:0034214)
0.0	0.1	GO:0002087	regulation of respiratory gaseous exchange by neurological system process(GO:0002087)
0.0	0.0	GO:0080111	DNA demethylation(GO:0080111)
0.0	0.2	GO:0032012	regulation of ARF protein signal transduction(GO:0032012)
0.0	0.1	GO:0050718	positive regulation of interleukin-1 beta secretion(GO:0050718)
0.0	0.4	GO:0050772	positive regulation of axonogenesis(GO:0050772)
0.0	0.1	GO:0030206	chondroitin sulfate biosynthetic process(GO:0030206)
0.0	0.2	GO:0042776	mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.0	0.3	GO:0006493	protein O-linked glycosylation(GO:0006493)
0.0	0.0	GO:0060684	epithelial-mesenchymal cell signaling(GO:0060684)
0.0	0.0	GO:0032968	positive regulation of transcription elongation from RNA polymerase II promoter(GO:0032968)
0.0	0.0	GO:0010457	centriole-centriole cohesion(GO:0010457)
0.0	0.0	GO:0046607	positive regulation of centrosome cycle(GO:0046607)
0.0	0.0	GO:0002282	microglial cell activation involved in immune response(GO:0002282)
0.0	0.1	GO:0003100	regulation of systemic arterial blood pressure by endothelin(GO:0003100)
0.0	0.0	GO:0060159	regulation of dopamine receptor signaling pathway(GO:0060159)
0.0	0.2	GO:0000245	spliceosomal complex assembly(GO:0000245)
0.0	0.0	GO:0007181	transforming growth factor beta receptor complex assembly(GO:0007181)
0.0	0.2	GO:0019933	cAMP-mediated signaling(GO:0019933)
0.0	0.1	GO:0043550	regulation of lipid kinase activity(GO:0043550)
0.0	0.0	GO:0070977	organ maturation(GO:0048799) bone maturation(GO:0070977)
0.0	0.0	GO:0042339	keratan sulfate metabolic process(GO:0042339)
0.0	0.1	GO:0009304	tRNA transcription(GO:0009304) 5S class rRNA transcription from RNA polymerase III type 1 promoter(GO:0042791) tRNA transcription from RNA polymerase III promoter(GO:0042797)
0.0	0.1	GO:0006269	DNA replication, synthesis of RNA primer(GO:0006269)
0.0	0.1	GO:0045948	positive regulation of translational initiation(GO:0045948)
0.0	0.8	GO:0006405	RNA export from nucleus(GO:0006405)
0.0	0.1	GO:0006657	CDP-choline pathway(GO:0006657)
0.0	0.2	GO:0006904	vesicle docking involved in exocytosis(GO:0006904)
0.0	0.1	GO:0001662	behavioral fear response(GO:0001662)
0.0	0.1	GO:0097154	GABAergic neuron differentiation(GO:0097154)
0.0	0.0	GO:0045409	negative regulation of interleukin-6 biosynthetic process(GO:0045409)
0.0	0.1	GO:0098657	neurotransmitter uptake(GO:0001504) import into cell(GO:0098657)
0.0	0.0	GO:0009313	oligosaccharide catabolic process(GO:0009313)
0.0	0.0	GO:0010535	regulation of activation of JAK2 kinase activity(GO:0010534) positive regulation of activation of JAK2 kinase activity(GO:0010535)
0.0	0.0	GO:0060123	regulation of growth hormone secretion(GO:0060123) positive regulation of growth hormone secretion(GO:0060124)
0.0	0.0	GO:0043568	positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568)
0.0	0.0	GO:0048304	positive regulation of isotype switching to IgG isotypes(GO:0048304)
0.0	0.1	GO:0042308	negative regulation of protein import into nucleus(GO:0042308) negative regulation of protein localization to nucleus(GO:1900181) negative regulation of protein import(GO:1904590)
0.0	0.0	GO:0006346	methylation-dependent chromatin silencing(GO:0006346)
0.0	0.1	GO:1901663	quinone biosynthetic process(GO:1901663)
0.0	0.0	GO:0021610	cranial nerve structural organization(GO:0021604) facial nerve morphogenesis(GO:0021610) facial nerve structural organization(GO:0021612) anatomical structure arrangement(GO:0048532)
0.0	0.0	GO:0006287	base-excision repair, gap-filling(GO:0006287)
0.0	0.0	GO:0045163	clustering of voltage-gated potassium channels(GO:0045163)
0.0	0.0	GO:0060662	tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662)
0.0	0.2	GO:0000188	inactivation of MAPK activity(GO:0000188)
0.0	0.0	GO:1903332	regulation of protein folding(GO:1903332)
0.0	0.1	GO:0045329	amino-acid betaine biosynthetic process(GO:0006578) carnitine biosynthetic process(GO:0045329)
0.0	0.0	GO:0060766	negative regulation of androgen receptor signaling pathway(GO:0060766)
0.0	0.0	GO:0042754	negative regulation of circadian sleep/wake cycle, sleep(GO:0042321) negative regulation of circadian rhythm(GO:0042754)
0.0	0.0	GO:0006154	adenosine catabolic process(GO:0006154)
0.0	0.2	GO:0042147	retrograde transport, endosome to Golgi(GO:0042147)
0.0	0.9	GO:0006415	translational termination(GO:0006415)
0.0	0.1	GO:0021707	cerebellar granular layer development(GO:0021681) cerebellar granular layer morphogenesis(GO:0021683) cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.0	0.1	GO:0051085	chaperone mediated protein folding requiring cofactor(GO:0051085)
0.0	0.2	GO:0032088	negative regulation of NF-kappaB transcription factor activity(GO:0032088)
0.0	0.0	GO:0021780	spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) oligodendrocyte cell fate specification(GO:0021778) glial cell fate specification(GO:0021780)
0.0	0.0	GO:0033314	mitotic DNA replication checkpoint(GO:0033314)
0.0	0.0	GO:1900619	acetylcholine metabolic process(GO:0008291) acetate ester metabolic process(GO:1900619)
0.0	0.0	GO:1903019	negative regulation of glycoprotein biosynthetic process(GO:0010561) negative regulation of glycoprotein metabolic process(GO:1903019)
0.0	0.0	GO:0007638	mechanosensory behavior(GO:0007638)
0.0	0.0	GO:0034447	very-low-density lipoprotein particle clearance(GO:0034447)
0.0	0.0	GO:0001706	endoderm formation(GO:0001706)
0.0	0.0	GO:0090400	stress-induced premature senescence(GO:0090400)
0.0	0.0	GO:0021799	cerebral cortex radially oriented cell migration(GO:0021799)
0.0	0.0	GO:0071801	regulation of podosome assembly(GO:0071801) positive regulation of podosome assembly(GO:0071803)
0.0	0.1	GO:0060487	lung epithelial cell differentiation(GO:0060487)
0.0	0.0	GO:1902803	regulation of synaptic vesicle transport(GO:1902803) regulation of synaptic vesicle exocytosis(GO:2000300)
0.0	0.1	GO:0030212	hyaluronan metabolic process(GO:0030212)
0.0	0.2	GO:0006997	nucleus organization(GO:0006997)
0.0	0.0	GO:0030240	skeletal muscle thin filament assembly(GO:0030240)
0.0	0.0	GO:0007183	SMAD protein complex assembly(GO:0007183)
0.0	0.0	GO:0032926	negative regulation of activin receptor signaling pathway(GO:0032926)
0.0	0.1	GO:0007032	endosome organization(GO:0007032)
0.0	0.0	GO:0032959	inositol trisphosphate biosynthetic process(GO:0032959)
0.0	0.0	GO:0032747	positive regulation of interleukin-23 production(GO:0032747)
0.0	0.0	GO:0006883	cellular sodium ion homeostasis(GO:0006883)
0.0	0.0	GO:0042447	hormone catabolic process(GO:0042447)
0.0	0.1	GO:0045746	negative regulation of Notch signaling pathway(GO:0045746)
0.0	0.0	GO:0006420	arginyl-tRNA aminoacylation(GO:0006420)
0.0	0.0	GO:0072202	cell differentiation involved in metanephros development(GO:0072202)
0.0	0.0	GO:0032106	positive regulation of response to extracellular stimulus(GO:0032106) positive regulation of response to nutrient levels(GO:0032109)
0.0	0.0	GO:0042596	fear response(GO:0042596)
0.0	0.1	GO:0030890	positive regulation of B cell proliferation(GO:0030890)
0.0	0.0	GO:0006189	'de novo' IMP biosynthetic process(GO:0006189)
0.0	0.1	GO:0001514	selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.6	GO:0001891	phagocytic cup(GO:0001891)
0.1	0.2	GO:0070022	transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.1	0.2	GO:0042105	alpha-beta T cell receptor complex(GO:0042105)
0.1	0.2	GO:0071256	Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.1	0.2	GO:0031235	intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.1	0.2	GO:0072487	MSL complex(GO:0072487)
0.0	0.1	GO:0000942	condensed nuclear chromosome outer kinetochore(GO:0000942)
0.0	0.1	GO:0032444	activin responsive factor complex(GO:0032444)
0.0	0.5	GO:0010494	cytoplasmic stress granule(GO:0010494)
0.0	0.1	GO:0070937	CRD-mediated mRNA stability complex(GO:0070937)
0.0	0.1	GO:0000214	tRNA-intron endonuclease complex(GO:0000214)
0.0	0.2	GO:0070552	BRISC complex(GO:0070552)
0.0	0.2	GO:0019907	cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
0.0	0.3	GO:0017119	Golgi transport complex(GO:0017119)
0.0	0.2	GO:0033256	I-kappaB/NF-kappaB complex(GO:0033256)
0.0	0.1	GO:0043159	acrosomal matrix(GO:0043159)
0.0	0.4	GO:0071203	WASH complex(GO:0071203)
0.0	0.2	GO:0098984	asymmetric synapse(GO:0032279) neuron to neuron synapse(GO:0098984)
0.0	0.2	GO:0000796	condensin complex(GO:0000796)
0.0	0.1	GO:0000137	Golgi cis cisterna(GO:0000137)
0.0	0.1	GO:0030056	hemidesmosome(GO:0030056)
0.0	0.4	GO:0005852	eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0	1.1	GO:0030175	filopodium(GO:0030175)
0.0	0.1	GO:0070775	H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0	0.2	GO:0042101	T cell receptor complex(GO:0042101)
0.0	0.3	GO:0034362	low-density lipoprotein particle(GO:0034362)
0.0	0.2	GO:0035098	ESC/E(Z) complex(GO:0035098)
0.0	0.1	GO:0071942	XPC complex(GO:0071942)
0.0	0.1	GO:0043596	nuclear replication fork(GO:0043596)
0.0	0.2	GO:0042382	paraspeckles(GO:0042382)
0.0	0.1	GO:0070695	FHF complex(GO:0070695)
0.0	0.2	GO:0034518	mRNA cap binding complex(GO:0005845) RNA cap binding complex(GO:0034518)
0.0	0.2	GO:0019773	proteasome core complex, alpha-subunit complex(GO:0019773)
0.0	0.4	GO:0030530	obsolete heterogeneous nuclear ribonucleoprotein complex(GO:0030530)
0.0	0.1	GO:0072357	PTW/PP1 phosphatase complex(GO:0072357)
0.0	0.1	GO:0030121	AP-1 adaptor complex(GO:0030121)
0.0	0.1	GO:0005863	striated muscle myosin thick filament(GO:0005863)
0.0	0.8	GO:0022625	cytosolic large ribosomal subunit(GO:0022625)
0.0	0.1	GO:0071001	U4/U6 snRNP(GO:0071001)
0.0	0.1	GO:0032009	early phagosome(GO:0032009)
0.0	0.3	GO:0030137	COPI-coated vesicle(GO:0030137)
0.0	0.2	GO:0031464	Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.0	0.1	GO:0000300	obsolete peripheral to membrane of membrane fraction(GO:0000300)
0.0	0.2	GO:0042589	zymogen granule membrane(GO:0042589)
0.0	0.2	GO:0045120	pronucleus(GO:0045120)
0.0	0.1	GO:0035189	Rb-E2F complex(GO:0035189)
0.0	0.1	GO:0072669	tRNA-splicing ligase complex(GO:0072669)
0.0	0.1	GO:0043218	compact myelin(GO:0043218)
0.0	0.1	GO:0000791	euchromatin(GO:0000791)
0.0	0.2	GO:0030877	beta-catenin destruction complex(GO:0030877)
0.0	0.4	GO:0019861	obsolete flagellum(GO:0019861)
0.0	0.1	GO:0030891	VCB complex(GO:0030891)
0.0	0.3	GO:0005801	cis-Golgi network(GO:0005801)
0.0	0.0	GO:0000778	condensed nuclear chromosome kinetochore(GO:0000778)
0.0	0.4	GO:0046658	anchored component of plasma membrane(GO:0046658)
0.0	0.1	GO:0070419	nonhomologous end joining complex(GO:0070419)
0.0	0.2	GO:0001772	immunological synapse(GO:0001772)
0.0	0.0	GO:0048188	Set1C/COMPASS complex(GO:0048188)
0.0	0.4	GO:0019005	SCF ubiquitin ligase complex(GO:0019005)
0.0	0.1	GO:0005827	polar microtubule(GO:0005827)
0.0	0.2	GO:0016585	obsolete chromatin remodeling complex(GO:0016585)
0.0	0.1	GO:0042719	mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.0	0.1	GO:0016593	Cdc73/Paf1 complex(GO:0016593)
0.0	0.2	GO:0008250	oligosaccharyltransferase complex(GO:0008250)
0.0	0.2	GO:0005732	small nucleolar ribonucleoprotein complex(GO:0005732)
0.0	0.2	GO:0043186	P granule(GO:0043186) pole plasm(GO:0045495) germ plasm(GO:0060293)
0.0	0.1	GO:0045179	apical cortex(GO:0045179)
0.0	0.3	GO:0005892	acetylcholine-gated channel complex(GO:0005892)
0.0	0.1	GO:0043209	myelin sheath(GO:0043209)
0.0	0.1	GO:0000346	transcription export complex(GO:0000346)
0.0	0.0	GO:0031932	TORC2 complex(GO:0031932)
0.0	0.5	GO:0042645	mitochondrial nucleoid(GO:0042645)
0.0	0.1	GO:0042555	MCM complex(GO:0042555)
0.0	0.1	GO:0045261	proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.0	0.0	GO:0019908	nuclear cyclin-dependent protein kinase holoenzyme complex(GO:0019908)
0.0	0.1	GO:0034451	centriolar satellite(GO:0034451)
0.0	0.0	GO:0031205	endoplasmic reticulum Sec complex(GO:0031205)
0.0	0.1	GO:0045334	clathrin-coated endocytic vesicle(GO:0045334)
0.0	0.1	GO:0005664	origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.0	0.1	GO:0031463	Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0	0.0	GO:0005900	oncostatin-M receptor complex(GO:0005900)
0.0	0.0	GO:0000138	Golgi trans cisterna(GO:0000138)
0.0	0.1	GO:0000242	pericentriolar material(GO:0000242)
0.0	0.0	GO:0005682	U5 snRNP(GO:0005682)
0.0	0.1	GO:0000127	transcription factor TFIIIC complex(GO:0000127)
0.0	0.0	GO:0048179	activin receptor complex(GO:0048179)
0.0	0.1	GO:0032590	dendrite membrane(GO:0032590)
0.0	0.1	GO:0005671	Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0	0.1	GO:0030893	meiotic cohesin complex(GO:0030893)
0.0	1.2	GO:0048770	melanosome(GO:0042470) pigment granule(GO:0048770)
0.0	0.2	GO:0005858	axonemal dynein complex(GO:0005858)
0.0	0.1	GO:0031371	ubiquitin conjugating enzyme complex(GO:0031371)
0.0	0.0	GO:0033553	rDNA heterochromatin(GO:0033553)
0.0	0.2	GO:0090544	BAF-type complex(GO:0090544)
0.0	0.2	GO:0030914	STAGA complex(GO:0030914)
0.0	0.1	GO:0000783	telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783)
0.0	0.1	GO:0031519	PcG protein complex(GO:0031519)
0.0	0.2	GO:0030131	clathrin adaptor complex(GO:0030131)
0.0	0.3	GO:0071339	MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.0	0.1	GO:0034045	pre-autophagosomal structure membrane(GO:0034045)
0.0	0.1	GO:0045283	mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.0	0.2	GO:0000159	protein phosphatase type 2A complex(GO:0000159)
0.0	0.0	GO:0032593	insulin-responsive compartment(GO:0032593)
0.0	0.0	GO:0071204	histone pre-mRNA 3'end processing complex(GO:0071204)
0.0	0.0	GO:0070044	synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
0.0	0.1	GO:0005942	phosphatidylinositol 3-kinase complex(GO:0005942)
0.0	0.4	GO:0005876	spindle microtubule(GO:0005876)
0.0	0.0	GO:0001740	Barr body(GO:0001740)
0.0	0.0	GO:0030895	apolipoprotein B mRNA editing enzyme complex(GO:0030895)
0.0	0.1	GO:0035631	CD40 receptor complex(GO:0035631)
0.0	0.0	GO:0005797	Golgi medial cisterna(GO:0005797)
0.0	0.3	GO:0043204	perikaryon(GO:0043204)
0.0	0.1	GO:0048500	signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.0	0.9	GO:0032993	protein-DNA complex(GO:0032993)
0.0	0.0	GO:0071778	obsolete WINAC complex(GO:0071778)
0.0	1.2	GO:0016607	nuclear speck(GO:0016607)
0.0	1.0	GO:0000151	ubiquitin ligase complex(GO:0000151)
0.0	0.1	GO:0042765	GPI-anchor transamidase complex(GO:0042765)
0.0	0.0	GO:0044216	host(GO:0018995) host cell part(GO:0033643) host intracellular part(GO:0033646) intracellular region of host(GO:0043656) host cell(GO:0043657) other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217)
0.0	0.3	GO:0016592	mediator complex(GO:0016592)
0.0	0.0	GO:0033270	paranode region of axon(GO:0033270)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0030284	estrogen receptor activity(GO:0030284)
0.1	0.3	GO:0035184	histone threonine kinase activity(GO:0035184)
0.1	0.3	GO:0004911	interleukin-2 receptor activity(GO:0004911)
0.1	0.2	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.1	0.2	GO:0047756	chondroitin 4-sulfotransferase activity(GO:0047756)
0.1	0.2	GO:0016309	1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.1	0.3	GO:0004974	leukotriene receptor activity(GO:0004974)
0.1	0.2	GO:0008454	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.1	0.2	GO:0008474	palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.1	0.6	GO:0016493	C-C chemokine receptor activity(GO:0016493)
0.1	0.2	GO:0008545	JUN kinase kinase activity(GO:0008545)
0.1	0.5	GO:0016274	arginine N-methyltransferase activity(GO:0016273) protein-arginine N-methyltransferase activity(GO:0016274)
0.1	0.2	GO:0015925	galactosidase activity(GO:0015925)
0.0	0.4	GO:0004176	ATP-dependent peptidase activity(GO:0004176)
0.0	1.1	GO:0045028	G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0	0.4	GO:0070410	co-SMAD binding(GO:0070410)
0.0	0.2	GO:0005381	iron ion transmembrane transporter activity(GO:0005381)
0.0	0.2	GO:0004774	succinate-CoA ligase activity(GO:0004774)
0.0	0.1	GO:0047631	ADP-ribose diphosphatase activity(GO:0047631)
0.0	0.1	GO:0004311	farnesyltranstransferase activity(GO:0004311)
0.0	0.2	GO:0045499	chemorepellent activity(GO:0045499)
0.0	0.2	GO:0070579	methylcytosine dioxygenase activity(GO:0070579)
0.0	0.1	GO:0004719	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.0	0.3	GO:0001784	phosphotyrosine binding(GO:0001784)
0.0	0.3	GO:0008318	protein prenyltransferase activity(GO:0008318)
0.0	0.2	GO:0016907	G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0	0.1	GO:0046404	ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734)
0.0	0.2	GO:0005375	copper ion transmembrane transporter activity(GO:0005375)
0.0	0.5	GO:0031593	polyubiquitin binding(GO:0031593)
0.0	0.2	GO:0016494	C-X-C chemokine receptor activity(GO:0016494)
0.0	0.1	GO:0005134	interleukin-2 receptor binding(GO:0005134)
0.0	0.5	GO:0005095	GTPase inhibitor activity(GO:0005095)
0.0	0.2	GO:0050733	RS domain binding(GO:0050733)
0.0	0.4	GO:0016922	ligand-dependent nuclear receptor binding(GO:0016922)
0.0	0.4	GO:0004697	protein kinase C activity(GO:0004697)
0.0	0.1	GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.0	0.1	GO:0019870	potassium channel inhibitor activity(GO:0019870)
0.0	0.1	GO:0034236	protein kinase A catalytic subunit binding(GO:0034236)
0.0	0.2	GO:0005499	vitamin D binding(GO:0005499)
0.0	0.1	GO:0048018	receptor agonist activity(GO:0048018)
0.0	0.2	GO:0051920	peroxiredoxin activity(GO:0051920)
0.0	0.1	GO:0004677	DNA-dependent protein kinase activity(GO:0004677)
0.0	0.2	GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0	0.1	GO:0004046	aminoacylase activity(GO:0004046)
0.0	0.5	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0	0.1	GO:0016842	amidine-lyase activity(GO:0016842)
0.0	0.1	GO:0019136	deoxynucleoside kinase activity(GO:0019136)
0.0	0.3	GO:0046875	ephrin receptor binding(GO:0046875)
0.0	0.1	GO:0032454	histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0	0.1	GO:0003909	DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.0	0.2	GO:0004691	cAMP-dependent protein kinase activity(GO:0004691)
0.0	0.1	GO:0008109	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0	0.1	GO:0070577	lysine-acetylated histone binding(GO:0070577)
0.0	0.4	GO:0043014	alpha-tubulin binding(GO:0043014)
0.0	1.0	GO:0004715	non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0	0.1	GO:0003836	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0	0.2	GO:0003828	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0	0.1	GO:0003726	double-stranded RNA adenosine deaminase activity(GO:0003726)
0.0	0.1	GO:0034713	type I transforming growth factor beta receptor binding(GO:0034713)
0.0	0.1	GO:0050253	retinyl-palmitate esterase activity(GO:0050253)
0.0	0.2	GO:0004568	chitinase activity(GO:0004568)
0.0	0.1	GO:0008467	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0	0.1	GO:0034481	chondroitin sulfotransferase activity(GO:0034481)
0.0	0.1	GO:0052650	NADP-retinol dehydrogenase activity(GO:0052650)
0.0	0.2	GO:0008158	hedgehog receptor activity(GO:0008158)
0.0	0.2	GO:0051879	Hsp90 protein binding(GO:0051879)
0.0	0.1	GO:0000739	obsolete DNA strand annealing activity(GO:0000739)
0.0	0.2	GO:0034593	phosphatidylinositol bisphosphate phosphatase activity(GO:0034593)
0.0	0.1	GO:0017162	aryl hydrocarbon receptor binding(GO:0017162)
0.0	0.4	GO:0005086	ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0	0.3	GO:0033549	MAP kinase phosphatase activity(GO:0033549)
0.0	0.1	GO:0000036	ACP phosphopantetheine attachment site binding involved in fatty acid biosynthetic process(GO:0000036) ACP phosphopantetheine attachment site binding(GO:0044620) prosthetic group binding(GO:0051192)
0.0	0.1	GO:0004563	beta-N-acetylhexosaminidase activity(GO:0004563)
0.0	0.1	GO:0031702	type 1 angiotensin receptor binding(GO:0031702)
0.0	0.1	GO:0005025	transforming growth factor beta receptor activity, type I(GO:0005025)
0.0	0.1	GO:0030911	TPR domain binding(GO:0030911)
0.0	0.1	GO:0035252	UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285)
0.0	0.1	GO:0016802	adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0	0.2	GO:0099604	calcium-release channel activity(GO:0015278) ligand-gated calcium channel activity(GO:0099604)
0.0	0.1	GO:0004749	ribose phosphate diphosphokinase activity(GO:0004749)
0.0	0.1	GO:0016882	cyclo-ligase activity(GO:0016882)
0.0	0.4	GO:0005164	tumor necrosis factor receptor binding(GO:0005164)
0.0	0.1	GO:0050815	phosphoserine binding(GO:0050815)
0.0	0.1	GO:0071208	histone pre-mRNA DCP binding(GO:0071208)
0.0	0.1	GO:0005087	Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.0	0.6	GO:0003950	NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0	0.1	GO:0005049	nuclear export signal receptor activity(GO:0005049)
0.0	0.4	GO:0051059	NF-kappaB binding(GO:0051059)
0.0	0.0	GO:0005527	macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0	0.0	GO:0016778	diphosphotransferase activity(GO:0016778)
0.0	0.2	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0	0.0	GO:0016635	oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor(GO:0016635)
0.0	0.1	GO:0070569	uridylyltransferase activity(GO:0070569)
0.0	0.1	GO:0050811	GABA receptor binding(GO:0050811)
0.0	0.1	GO:0005042	netrin receptor activity(GO:0005042)
0.0	0.1	GO:0005094	Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0	0.1	GO:0004652	polynucleotide adenylyltransferase activity(GO:0004652)
0.0	0.6	GO:0003727	single-stranded RNA binding(GO:0003727)
0.0	0.3	GO:0015026	coreceptor activity(GO:0015026)
0.0	0.2	GO:0030332	cyclin binding(GO:0030332)
0.0	0.0	GO:0035197	siRNA binding(GO:0035197)
0.0	0.1	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.0	0.1	GO:0015252	hydrogen ion channel activity(GO:0015252)
0.0	0.1	GO:0004904	interferon receptor activity(GO:0004904)
0.0	0.2	GO:0030515	snoRNA binding(GO:0030515)
0.0	0.1	GO:0004427	inorganic diphosphatase activity(GO:0004427)
0.0	0.0	GO:0070644	vitamin D response element binding(GO:0070644)
0.0	0.1	GO:0000247	C-8 sterol isomerase activity(GO:0000247)
0.0	0.1	GO:0033300	dehydroascorbic acid transporter activity(GO:0033300)
0.0	0.1	GO:0035514	DNA demethylase activity(GO:0035514) DNA-N1-methyladenine dioxygenase activity(GO:0043734)
0.0	0.1	GO:0008900	hydrogen:potassium-exchanging ATPase activity(GO:0008900)
0.0	0.1	GO:0004995	tachykinin receptor activity(GO:0004995)
0.0	0.1	GO:0004614	phosphoglucomutase activity(GO:0004614)
0.0	0.1	GO:0015379	potassium:chloride symporter activity(GO:0015379)
0.0	0.1	GO:0003960	NADPH:quinone reductase activity(GO:0003960)
0.0	0.1	GO:0004000	adenosine deaminase activity(GO:0004000)
0.0	0.1	GO:0031996	thioesterase binding(GO:0031996)
0.0	0.1	GO:0048156	tau protein binding(GO:0048156)
0.0	0.1	GO:0008195	phosphatidate phosphatase activity(GO:0008195)
0.0	0.1	GO:0019788	NEDD8 transferase activity(GO:0019788)
0.0	0.1	GO:0003785	actin monomer binding(GO:0003785)
0.0	0.2	GO:0004065	arylsulfatase activity(GO:0004065)
0.0	0.2	GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0	0.1	GO:0019911	structural constituent of myelin sheath(GO:0019911)
0.0	0.1	GO:0016423	tRNA (guanine) methyltransferase activity(GO:0016423)
0.0	0.6	GO:0101005	thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.0	0.1	GO:0022889	L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.0	0.1	GO:0004047	aminomethyltransferase activity(GO:0004047)
0.0	0.1	GO:0003688	DNA replication origin binding(GO:0003688)
0.0	0.1	GO:0042392	sphingosine-1-phosphate phosphatase activity(GO:0042392)
0.0	0.2	GO:0030742	GTP-dependent protein binding(GO:0030742)
0.0	0.0	GO:0015924	mannosyl-oligosaccharide mannosidase activity(GO:0015924)
0.0	0.2	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0	0.1	GO:0008159	obsolete positive transcription elongation factor activity(GO:0008159)
0.0	0.1	GO:0004969	histamine receptor activity(GO:0004969)
0.0	0.1	GO:0004815	aspartate-tRNA ligase activity(GO:0004815)
0.0	0.3	GO:0008601	protein phosphatase type 2A regulator activity(GO:0008601)
0.0	0.1	GO:0043422	protein kinase B binding(GO:0043422)
0.0	0.0	GO:0098518	polynucleotide phosphatase activity(GO:0098518)
0.0	0.1	GO:0046912	transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.0	0.2	GO:0051721	protein phosphatase 2A binding(GO:0051721)
0.0	0.1	GO:0016312	inositol bisphosphate phosphatase activity(GO:0016312)
0.0	0.1	GO:0008420	CTD phosphatase activity(GO:0008420)
0.0	0.8	GO:0003743	translation initiation factor activity(GO:0003743)
0.0	0.1	GO:0043425	bHLH transcription factor binding(GO:0043425)
0.0	0.2	GO:0005246	calcium channel regulator activity(GO:0005246)
0.0	0.0	GO:0004886	9-cis retinoic acid receptor activity(GO:0004886)
0.0	0.0	GO:0030368	interleukin-17 receptor activity(GO:0030368)
0.0	0.1	GO:0016857	racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.0	0.1	GO:0034452	dynactin binding(GO:0034452)
0.0	0.1	GO:0000900	translation repressor activity, nucleic acid binding(GO:0000900)
0.0	0.0	GO:0031701	angiotensin receptor binding(GO:0031701)
0.0	0.1	GO:0030229	very-low-density lipoprotein particle receptor activity(GO:0030229)
0.0	0.3	GO:0003725	double-stranded RNA binding(GO:0003725)
0.0	0.2	GO:0042809	vitamin D receptor binding(GO:0042809)
0.0	0.1	GO:0050998	nitric-oxide synthase binding(GO:0050998)
0.0	0.0	GO:0016149	translation release factor activity, codon specific(GO:0016149)
0.0	0.0	GO:0043047	single-stranded telomeric DNA binding(GO:0043047) sequence-specific single stranded DNA binding(GO:0098847)
0.0	0.0	GO:0032139	dinucleotide insertion or deletion binding(GO:0032139)
0.0	0.0	GO:0004659	prenyltransferase activity(GO:0004659)
0.0	0.1	GO:0070411	I-SMAD binding(GO:0070411)
0.0	0.1	GO:0032452	histone demethylase activity(GO:0032452)
0.0	0.2	GO:0004407	histone deacetylase activity(GO:0004407)
0.0	0.1	GO:0017176	phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0	0.1	GO:0017112	Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0	0.1	GO:0001609	G-protein coupled adenosine receptor activity(GO:0001609)
0.0	0.1	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0	0.1	GO:0003709	obsolete RNA polymerase III transcription factor activity(GO:0003709)
0.0	0.0	GO:0033691	sialic acid binding(GO:0033691)
0.0	0.1	GO:0003964	telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964)
0.0	0.0	GO:0019211	phosphatase activator activity(GO:0019211)
0.0	0.0	GO:0004591	oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.0	0.0	GO:0000064	L-ornithine transmembrane transporter activity(GO:0000064)
0.0	0.1	GO:0004957	prostaglandin E receptor activity(GO:0004957)
0.0	0.0	GO:0043398	HLH domain binding(GO:0043398)
0.0	1.2	GO:0016566	obsolete specific transcriptional repressor activity(GO:0016566)
0.0	0.2	GO:0019534	toxin transporter activity(GO:0019534)
0.0	0.0	GO:0004576	oligosaccharyl transferase activity(GO:0004576)
0.0	0.0	GO:0032558	purine deoxyribonucleotide binding(GO:0032554) adenyl deoxyribonucleotide binding(GO:0032558)
0.0	0.1	GO:0008536	Ran GTPase binding(GO:0008536)
0.0	0.2	GO:0004889	acetylcholine-activated cation-selective channel activity(GO:0004889)
0.0	0.1	GO:0050750	low-density lipoprotein particle receptor binding(GO:0050750)
0.0	0.1	GO:0031013	troponin I binding(GO:0031013)
0.0	0.2	GO:0017075	syntaxin-1 binding(GO:0017075)
0.0	0.1	GO:0030276	clathrin binding(GO:0030276)
0.0	0.1	GO:0004301	epoxide hydrolase activity(GO:0004301)
0.0	0.1	GO:0019783	ubiquitin-like protein-specific protease activity(GO:0019783)
0.0	0.0	GO:0005131	growth hormone receptor binding(GO:0005131)
0.0	0.1	GO:0004767	sphingomyelin phosphodiesterase activity(GO:0004767)
0.0	0.1	GO:0046923	ER retention sequence binding(GO:0046923)
0.0	0.0	GO:0019959	C-X-C chemokine binding(GO:0019958) interleukin-8 binding(GO:0019959)
0.0	0.1	GO:0070567	cytidylyltransferase activity(GO:0070567)
0.0	0.1	GO:0005047	signal recognition particle binding(GO:0005047)
0.0	0.1	GO:0003906	DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906)
0.0	0.1	GO:0090079	translation regulator activity, nucleic acid binding(GO:0090079)
0.0	0.0	GO:0004735	pyrroline-5-carboxylate reductase activity(GO:0004735)
0.0	0.1	GO:0000104	succinate dehydrogenase activity(GO:0000104)
0.0	0.0	GO:0043008	ATP-dependent protein binding(GO:0043008)
0.0	0.0	GO:0008853	exodeoxyribonuclease III activity(GO:0008853)
0.0	0.1	GO:0015211	purine nucleoside transmembrane transporter activity(GO:0015211)
0.0	1.8	GO:0003735	structural constituent of ribosome(GO:0003735)
0.0	0.0	GO:0016748	succinyltransferase activity(GO:0016748)
0.0	0.1	GO:0015385	sodium:proton antiporter activity(GO:0015385)
0.0	0.0	GO:0045569	TRAIL binding(GO:0045569)
0.0	0.1	GO:0003857	3-hydroxyacyl-CoA dehydrogenase activity(GO:0003857)
0.0	0.3	GO:0050681	androgen receptor binding(GO:0050681)
0.0	0.1	GO:0015288	porin activity(GO:0015288)
0.0	0.1	GO:0043325	phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0	0.0	GO:0003896	DNA primase activity(GO:0003896)
0.0	0.0	GO:0016453	C-acetyltransferase activity(GO:0016453)
0.0	0.1	GO:0031419	cobalamin binding(GO:0031419)
0.0	0.0	GO:0030976	thiamine pyrophosphate binding(GO:0030976)
0.0	0.0	GO:0008327	methyl-CpG binding(GO:0008327)
0.0	0.1	GO:0008301	DNA binding, bending(GO:0008301)
0.0	0.1	GO:0070064	proline-rich region binding(GO:0070064)
0.0	0.1	GO:0004983	neuropeptide Y receptor activity(GO:0004983)
0.0	0.1	GO:0004457	lactate dehydrogenase activity(GO:0004457)
0.0	0.0	GO:0008073	ornithine decarboxylase inhibitor activity(GO:0008073)
0.0	0.1	GO:0005416	cation:amino acid symporter activity(GO:0005416)
0.0	0.1	GO:0035251	UDP-glucosyltransferase activity(GO:0035251)
0.0	0.1	GO:0003923	GPI-anchor transamidase activity(GO:0003923)
0.0	0.0	GO:0003747	translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.0	0.3	GO:0003755	peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.0	0.4	GO:0003707	steroid hormone receptor activity(GO:0003707)
0.0	0.1	GO:0070566	adenylyltransferase activity(GO:0070566)
0.0	0.2	GO:0051117	ATPase binding(GO:0051117)
0.0	0.1	GO:0016668	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668)
0.0	0.0	GO:0004814	arginine-tRNA ligase activity(GO:0004814)
0.0	0.1	GO:0004126	cytidine deaminase activity(GO:0004126)
0.0	0.1	GO:0003691	double-stranded telomeric DNA binding(GO:0003691)
0.0	0.1	GO:0008526	phosphatidylinositol transporter activity(GO:0008526)
0.0	0.1	GO:0005388	calcium-transporting ATPase activity(GO:0005388)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.1	PID IL8 CXCR2 PATHWAY	IL8- and CXCR2-mediated signaling events
0.1	0.1	PID S1P S1P3 PATHWAY	S1P3 pathway
0.1	2.9	PID CD8 TCR PATHWAY	TCR signaling in naïve CD8+ T cells
0.0	1.2	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.0	0.4	ST INTERFERON GAMMA PATHWAY	Interferon gamma pathway.
0.0	1.5	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0	0.1	ST JNK MAPK PATHWAY	JNK MAPK Pathway
0.0	0.1	PID GLYPICAN 1PATHWAY	Glypican 1 network
0.0	0.0	PID TCPTP PATHWAY	Signaling events mediated by TCPTP
0.0	0.6	PID CD40 PATHWAY	CD40/CD40L signaling
0.0	0.7	PID MYC PATHWAY	C-MYC pathway
0.0	1.2	PID AR TF PATHWAY	Regulation of Androgen receptor activity
0.0	0.3	SA G1 AND S PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.0	0.5	PID IL2 1PATHWAY	IL2-mediated signaling events
0.0	0.2	PID PI3KCI AKT PATHWAY	Class I PI3K signaling events mediated by Akt
0.0	0.2	PID ERB GENOMIC PATHWAY	Validated nuclear estrogen receptor beta network
0.0	0.1	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
0.0	0.2	PID P38 ALPHA BETA PATHWAY	Regulation of p38-alpha and p38-beta
0.0	0.3	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
0.0	0.5	PID ERBB1 INTERNALIZATION PATHWAY	Internalization of ErbB1
0.0	0.3	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0	0.5	PID PI3KCI PATHWAY	Class I PI3K signaling events
0.0	0.5	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
0.0	0.1	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0	0.0	PID IFNG PATHWAY	IFN-gamma pathway
0.0	0.7	PID P53 REGULATION PATHWAY	p53 pathway
0.0	0.1	PID IL5 PATHWAY	IL5-mediated signaling events
0.0	0.3	PID BCR 5PATHWAY	BCR signaling pathway
0.0	0.1	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
0.0	0.2	PID IL12 STAT4 PATHWAY	IL12 signaling mediated by STAT4
0.0	0.1	PID RANBP2 PATHWAY	Sumoylation by RanBP2 regulates transcriptional repression
0.0	0.2	PID INSULIN GLUCOSE PATHWAY	Insulin-mediated glucose transport
0.0	0.2	PID DNA PK PATHWAY	DNA-PK pathway in nonhomologous end joining
0.0	0.2	PID IL2 PI3K PATHWAY	IL2 signaling events mediated by PI3K
0.0	0.2	PID BETA CATENIN DEG PATHWAY	Degradation of beta catenin
0.0	0.0	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.0	0.1	ST TYPE I INTERFERON PATHWAY	Type I Interferon (alpha/beta IFN) Pathway
0.0	0.3	PID NFAT 3PATHWAY	Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.0	0.0	SIG BCR SIGNALING PATHWAY	Members of the BCR signaling pathway
0.0	0.2	PID THROMBIN PAR4 PATHWAY	PAR4-mediated thrombin signaling events
0.0	0.2	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0	0.1	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.0	0.4	PID TNF PATHWAY	TNF receptor signaling pathway
0.0	0.2	SA CASPASE CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0	0.0	ST GRANULE CELL SURVIVAL PATHWAY	Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.0	0.1	PID IL3 PATHWAY	IL3-mediated signaling events
0.0	0.2	PID EPHB FWD PATHWAY	EPHB forward signaling
0.0	0.1	ST B CELL ANTIGEN RECEPTOR	B Cell Antigen Receptor
0.0	0.3	ST G ALPHA I PATHWAY	G alpha i Pathway
0.0	0.2	PID HEDGEHOG GLI PATHWAY	Hedgehog signaling events mediated by Gli proteins
0.0	0.1	PID FOXO PATHWAY	FoxO family signaling
0.0	0.2	PID CERAMIDE PATHWAY	Ceramide signaling pathway
0.0	0.5	PID ERA GENOMIC PATHWAY	Validated nuclear estrogen receptor alpha network
0.0	0.0	ST TUMOR NECROSIS FACTOR PATHWAY	Tumor Necrosis Factor Pathway.
0.0	0.1	PID ECADHERIN KERATINOCYTE PATHWAY	E-cadherin signaling in keratinocytes
0.0	0.1	PID INTEGRIN3 PATHWAY	Beta3 integrin cell surface interactions
0.0	0.1	PID S1P META PATHWAY	Sphingosine 1-phosphate (S1P) pathway
0.0	0.0	ST GAQ PATHWAY	G alpha q Pathway
0.0	0.2	PID CONE PATHWAY	Visual signal transduction: Cones
0.0	0.4	PID PLK1 PATHWAY	PLK1 signaling events
0.0	0.1	PID PTP1B PATHWAY	Signaling events mediated by PTP1B
0.0	0.1	PID CIRCADIAN PATHWAY	Circadian rhythm pathway
0.0	0.0	PID EPHA2 FWD PATHWAY	EPHA2 forward signaling
0.0	0.1	PID PRL SIGNALING EVENTS PATHWAY	Signaling events mediated by PRL

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.2	REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS	Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.1	0.1	REACTOME SIGNALING BY ERBB2	Genes involved in Signaling by ERBB2
0.1	0.1	REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE	Genes involved in Translocation of ZAP-70 to Immunological synapse
0.1	0.8	REACTOME CD28 DEPENDENT VAV1 PATHWAY	Genes involved in CD28 dependent Vav1 pathway
0.1	0.6	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
0.0	0.7	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0	0.4	REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION	Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0	0.4	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.0	0.9	REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA	Genes involved in Circadian Repression of Expression by REV-ERBA
0.0	0.0	REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING	Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0	0.6	REACTOME IL RECEPTOR SHC SIGNALING	Genes involved in Interleukin receptor SHC signaling
0.0	0.1	REACTOME IRAK1 RECRUITS IKK COMPLEX	Genes involved in IRAK1 recruits IKK complex
0.0	0.4	REACTOME REGULATION OF IFNG SIGNALING	Genes involved in Regulation of IFNG signaling
0.0	0.5	REACTOME CTLA4 INHIBITORY SIGNALING	Genes involved in CTLA4 inhibitory signaling
0.0	0.1	REACTOME PD1 SIGNALING	Genes involved in PD-1 signaling
0.0	0.3	REACTOME COSTIMULATION BY THE CD28 FAMILY	Genes involved in Costimulation by the CD28 family
0.0	0.1	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.0	0.6	REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE	Genes involved in Synthesis of PIPs at the plasma membrane
0.0	0.5	REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY	Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0	0.1	REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	Genes involved in DCC mediated attractive signaling
0.0	0.5	REACTOME TCR SIGNALING	Genes involved in TCR signaling
0.0	0.0	REACTOME GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK	Genes involved in Gastrin-CREB signalling pathway via PKC and MAPK
0.0	0.2	REACTOME TRAF6 MEDIATED NFKB ACTIVATION	Genes involved in TRAF6 mediated NF-kB activation
0.0	0.3	REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0	0.4	REACTOME N GLYCAN ANTENNAE ELONGATION	Genes involved in N-Glycan antennae elongation
0.0	0.5	REACTOME CITRIC ACID CYCLE TCA CYCLE	Genes involved in Citric acid cycle (TCA cycle)
0.0	0.3	REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS	Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0	0.1	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING	Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.0	0.5	REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0	0.0	REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS	Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0	0.0	REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION	Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0	0.3	REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE	Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0	0.3	REACTOME RAP1 SIGNALLING	Genes involved in Rap1 signalling
0.0	0.3	REACTOME ENOS ACTIVATION AND REGULATION	Genes involved in eNOS activation and regulation
0.0	0.3	REACTOME THE ACTIVATION OF ARYLSULFATASES	Genes involved in The activation of arylsulfatases
0.0	0.1	REACTOME INTEGRATION OF PROVIRUS	Genes involved in Integration of provirus
0.0	0.1	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
0.0	0.1	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.0	0.6	REACTOME G1 PHASE	Genes involved in G1 Phase
0.0	0.3	REACTOME EICOSANOID LIGAND BINDING RECEPTORS	Genes involved in Eicosanoid ligand-binding receptors
0.0	0.1	REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX	Genes involved in Association of licensing factors with the pre-replicative complex
0.0	0.1	REACTOME REGULATION OF BETA CELL DEVELOPMENT	Genes involved in Regulation of beta-cell development
0.0	0.1	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION	Genes involved in TRAF6 mediated IRF7 activation
0.0	0.2	REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX	Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex
0.0	0.2	REACTOME INFLUENZA LIFE CYCLE	Genes involved in Influenza Life Cycle
0.0	0.1	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.0	0.3	REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING	Genes involved in Downregulation of TGF-beta receptor signaling
0.0	1.0	REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES	Genes involved in Antiviral mechanism by IFN-stimulated genes
0.0	0.1	REACTOME ABORTIVE ELONGATION OF HIV1 TRANSCRIPT IN THE ABSENCE OF TAT	Genes involved in Abortive elongation of HIV-1 transcript in the absence of Tat
0.0	0.3	REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0	0.2	REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION	Genes involved in Apoptosis induced DNA fragmentation
0.0	0.1	REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G	Genes involved in Vif-mediated degradation of APOBEC3G
0.0	0.3	REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI	Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0	0.1	REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY	Genes involved in Regulation of the Fanconi anemia pathway
0.0	0.3	REACTOME CHOLESTEROL BIOSYNTHESIS	Genes involved in Cholesterol biosynthesis
0.0	0.2	REACTOME HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS	Genes involved in Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
0.0	0.0	REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0	0.1	REACTOME G1 S SPECIFIC TRANSCRIPTION	Genes involved in G1/S-Specific Transcription
0.0	0.2	REACTOME NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR NLR SIGNALING PATHWAYS	Genes involved in Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
0.0	1.5	REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION	Genes involved in 3' -UTR-mediated translational regulation
0.0	0.4	REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER	Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.0	0.2	REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	Genes involved in Regulation of gene expression in beta cells
0.0	0.1	REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR	Genes involved in Trafficking and processing of endosomal TLR
0.0	0.2	REACTOME P38MAPK EVENTS	Genes involved in p38MAPK events
0.0	0.2	REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING	Genes involved in Formation of ATP by chemiosmotic coupling
0.0	0.0	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.0	1.4	REACTOME PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA	Genes involved in Processing of Capped Intron-Containing Pre-mRNA
0.0	0.0	REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS	Genes involved in Interactions of Vpr with host cellular proteins
0.0	0.3	REACTOME INSULIN SYNTHESIS AND PROCESSING	Genes involved in Insulin Synthesis and Processing
0.0	0.1	REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS	Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0	0.3	REACTOME GLYCOSPHINGOLIPID METABOLISM	Genes involved in Glycosphingolipid metabolism
0.0	0.8	REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS	Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.0	0.2	REACTOME NOD1 2 SIGNALING PATHWAY	Genes involved in NOD1/2 Signaling Pathway
0.0	0.1	REACTOME REGULATORY RNA PATHWAYS	Genes involved in Regulatory RNA pathways
0.0	0.1	REACTOME TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX	Genes involved in TRAF6 mediated induction of TAK1 complex
0.0	0.1	REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0	0.6	REACTOME PACKAGING OF TELOMERE ENDS	Genes involved in Packaging Of Telomere Ends
0.0	0.2	REACTOME METAL ION SLC TRANSPORTERS	Genes involved in Metal ion SLC transporters
0.0	0.5	REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1	Genes involved in SCF-beta-TrCP mediated degradation of Emi1
0.0	0.0	REACTOME NEF MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS	Genes involved in Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
0.0	0.1	REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN	Genes involved in Platelet Adhesion to exposed collagen
0.0	0.2	REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE	Genes involved in Synthesis of PIPs at the Golgi membrane
0.0	0.2	REACTOME MITOCHONDRIAL TRNA AMINOACYLATION	Genes involved in Mitochondrial tRNA aminoacylation
0.0	0.1	REACTOME COPI MEDIATED TRANSPORT	Genes involved in COPI Mediated Transport
0.0	0.1	REACTOME MRNA PROCESSING	Genes involved in mRNA Processing
0.0	0.1	REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Glutamate Neurotransmitter Release Cycle
0.0	0.2	REACTOME CHONDROITIN SULFATE BIOSYNTHESIS	Genes involved in Chondroitin sulfate biosynthesis
0.0	0.1	REACTOME HYALURONAN UPTAKE AND DEGRADATION	Genes involved in Hyaluronan uptake and degradation
0.0	0.1	REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA	Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0	0.1	REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION	Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0	0.0	REACTOME DSCAM INTERACTIONS	Genes involved in DSCAM interactions
0.0	0.1	REACTOME CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION	Genes involved in Cyclin E associated events during G1/S transition
0.0	0.1	REACTOME ERKS ARE INACTIVATED	Genes involved in ERKs are inactivated
0.0	0.3	REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS	Genes involved in Sphingolipid de novo biosynthesis

Results for OTX1

Z-value: 1.52

Motif logo

Transcription factors associated with OTX1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Activity of the OTX1 motif across conditions

Conditions sorted by the z-value of the OTX1 motif activity

Top target CREs of the motif:

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of OTX1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: