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ENCODE: H3K4me1 ChIP-Seq of primary human cells
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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for OVOL1

Z-value: 1.77

Motif logo

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Transcription factors associated with OVOL1

Gene Symbol Gene ID Gene Info
OVOL1
ENSG00000172818.5 OVOL1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
OVOL1chr11_65554544_655548642110.857680-0.713.3e-02Click!
OVOL1chr11_65560041_6556019210640.285028-0.675.0e-02Click!
OVOL1chr11_65553168_6555331912500.2596400.541.3e-01Click!
OVOL1chr11_65553927_655541624490.655477-0.284.7e-01Click!
OVOL1chr11_65555313_6555594711370.266395-0.245.3e-01Click!

Activity of the OVOL1 motif across conditions

Conditions sorted by the z-value of the OVOL1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr11_121318382_121318533 0.60 SORL1
 sortilin-related receptor, L(DLR class) A repeats containing
 4455
 0.27
chr1_198631816_198632541 0.51 RP11-553K8.5
4012
 0.29
chr1_100893242_100893421 0.49 ENSG00000216067
 .
 49000
 0.12
chr5_14584910_14585422 0.48 FAM105A
 family with sequence similarity 105, member A
 3282
 0.32
chr2_208407990_208408141 0.46 CREB1
 cAMP responsive element binding protein 1
 6920
 0.21
chr13_100194423_100194578 0.45 ENSG00000212197
 .
 5850
 0.2
chr3_187696515_187696882 0.44 LPP
 LIM domain containing preferred translocation partner in lipoma
 174374
 0.03
chr13_50895355_50895506 0.42 ENSG00000221198
 .
 41943
 0.2
chr5_98257924_98258111 0.42 CHD1
 chromodomain helicase DNA binding protein 1
 4223
 0.24
chr12_46274112_46274320 0.41 ENSG00000265093
 .
 6404
 0.25
chr15_76823679_76823830 0.40 ENSG00000266449
 .
 55234
 0.16
chr5_110568991_110569142 0.39 CAMK4
 calcium/calmodulin-dependent protein kinase IV
 9282
 0.23
chrX_12966242_12966440 0.39 TMSB4X
 thymosin beta 4, X-linked
 26886
 0.17
chr20_47433865_47434068 0.39 PREX1
 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
 10454
 0.27
chr6_87910032_87910183 0.39 ZNF292
 zinc finger protein 292
 33135
 0.16
chr6_12049983_12050134 0.39 HIVEP1
 human immunodeficiency virus type I enhancer binding protein 1
 34238
 0.21
chr8_22395773_22395982 0.39 RP11-582J16.4
7041
 0.12
chr7_151195847_151195998 0.38 RHEB
 Ras homolog enriched in brain
 19233
 0.15
chr10_28338660_28338811 0.38 ARMC4
 armadillo repeat containing 4
 50758
 0.17
chr17_46491252_46491403 0.38 SKAP1
 src kinase associated phosphoprotein 1
 16225
 0.13
chr1_226186534_226186685 0.38 SDE2
 SDE2 telomere maintenance homolog (S. pombe)
 423
 0.81
chr16_8910898_8911120 0.37 PMM2
 phosphomannomutase 2
 19285
 0.11
chr16_27249314_27249714 0.36 NSMCE1
 non-SMC element 1 homolog (S. cerevisiae)
 5115
 0.19
chr13_32419048_32419199 0.35 RXFP2
 relaxin/insulin-like family peptide receptor 2
 105444
 0.07
chr13_41150205_41150813 0.35 AL133318.1
 Uncharacterized protein
 39186
 0.18
chr19_14552535_14552708 0.35 PKN1
 protein kinase N1
 1549
 0.26
chr19_51627090_51627315 0.35 SIGLEC9
 sialic acid binding Ig-like lectin 9
 963
 0.35
chr16_28180681_28180897 0.35 XPO6
 exportin 6
 433
 0.82
chr11_35279256_35279449 0.35 SLC1A2
 solute carrier family 1 (glial high affinity glutamate transporter), member 2
 7940
 0.17
chr1_32370977_32371128 0.34 AL136115.1
 HCG2032337; PRO1848; Uncharacterized protein
 8122
 0.18
chrX_82764716_82764867 0.33 RP3-326L13.2
569
 0.74
chr7_5811904_5812111 0.33 RNF216
 ring finger protein 216
 9244
 0.19
chr3_71533544_71533695 0.33 ENSG00000221264
 .
 57621
 0.13
chr5_49809155_49809306 0.33 EMB
 embigin
 72029
 0.13
chr15_85305818_85306017 0.33 RP11-7M10.2
9564
 0.14
chr9_93432588_93432739 0.33 DIRAS2
 DIRAS family, GTP-binding RAS-like 2
 27277
 0.27
chr18_76393370_76393521 0.33 ENSG00000201723
 .
 89257
 0.1
chr5_70795874_70796025 0.33 BDP1
 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB
 44507
 0.16
chr8_2092374_2092525 0.33 MYOM2
 myomesin 2
 99265
 0.08
chr19_36444775_36445044 0.32 LRFN3
 leucine rich repeat and fibronectin type III domain containing 3
 16887
 0.09
chr8_104580754_104580905 0.32 RP11-1C8.4
66925
 0.1
chr13_72423364_72423515 0.32 DACH1
 dachshund homolog 1 (Drosophila)
 17468
 0.3
chr3_48511390_48511563 0.31 SHISA5
 shisa family member 5
 3141
 0.12
chrX_123477343_123477494 0.31 SH2D1A
 SH2 domain containing 1A
 2776
 0.41
chr18_56352456_56352746 0.31 RP11-126O1.4
7755
 0.16
chr13_46757884_46758155 0.31 LCP1
 lymphocyte cytosolic protein 1 (L-plastin)
 1560
 0.34
chr16_88367012_88367357 0.31 ZNF469
 zinc finger protein 469
 126695
 0.05
chr14_104113341_104113492 0.31 KLC1
 kinesin light chain 1
 17782
 0.09
chr2_174819637_174819834 0.31 SP3
 Sp3 transcription factor
 9212
 0.32
chr2_198162795_198162946 0.31 ANKRD44-IT1
 ANKRD44 intronic transcript 1 (non-protein coding)
 4373
 0.2
chr1_7833015_7833166 0.30 VAMP3
 vesicle-associated membrane protein 3
 323
 0.85
chr6_167531770_167531921 0.30 CCR6
 chemokine (C-C motif) receptor 6
 4412
 0.22
chr9_92151633_92152777 0.30 SEMA4D
 sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
 39160
 0.16
chr2_174818932_174819088 0.30 SP3
 Sp3 transcription factor
 9937
 0.31
chr14_91534223_91534420 0.30 C14orf159
 chromosome 14 open reading frame 159
 7145
 0.18
chr2_99254248_99254400 0.30 UNC50
 unc-50 homolog (C. elegans)
 21655
 0.17
chr2_36968243_36968422 0.30 VIT
 vitrin
 32623
 0.19
chr6_130455724_130456124 0.30 RP11-73O6.3
3417
 0.3
chr10_44296785_44297025 0.30 ZNF32
 zinc finger protein 32
 152601
 0.04
chr9_90896091_90896335 0.30 ENSG00000252299
 .
 92971
 0.09
chr18_21040575_21040726 0.30 ENSG00000199357
 .
 4315
 0.19
chr15_55622605_55622756 0.30 PIGB
 phosphatidylinositol glycan anchor biosynthesis, class B
 11237
 0.14
chr5_52914442_52914593 0.29 ENSG00000238508
 .
 9100
 0.27
chr8_20045702_20045912 0.29 SLC18A1
 solute carrier family 18 (vesicular monoamine transporter), member 1
 5090
 0.21
chr2_191353674_191353825 0.29 MFSD6
 major facilitator superfamily domain containing 6
 19507
 0.16
chr5_114632876_114633106 0.29 CCDC112
 coiled-coil domain containing 112
 463
 0.83
chr14_81483256_81483407 0.29 CEP128
 centrosomal protein 128kDa
 57483
 0.14
chr1_28217565_28217790 0.29 RPA2
 replication protein A2, 32kDa
 5919
 0.13
chr15_69083761_69083930 0.29 ENSG00000265195
 .
 10419
 0.23
chr4_122173636_122173787 0.29 TNIP3
 TNFAIP3 interacting protein 3
 25090
 0.2
chr4_68159778_68159929 0.29 ENSG00000206629
 .
 135619
 0.05
chr2_113934390_113934860 0.29 AC016683.5
1688
 0.27
chr2_106492472_106492672 0.29 AC009505.2
18939
 0.22
chr6_16420917_16421068 0.29 ENSG00000265642
 .
 7762
 0.31
chr5_140988503_140988751 0.28 AC008781.7
9354
 0.11
chr7_132943007_132943158 0.28 ENSG00000238844
 .
 4403
 0.27
chr5_139646644_139646795 0.28 PFDN1
 prefoldin subunit 1
 35949
 0.11
chr5_142808848_142808999 0.28 NR3C1
 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
 5344
 0.32
chr10_70061833_70061984 0.28 PBLD
 phenazine biosynthesis-like protein domain containing
 5017
 0.21
chr1_10209396_10209547 0.28 ENSG00000201746
 .
 13855
 0.17
chr2_42435001_42435282 0.28 AC083949.1
37700
 0.17
chr12_12530514_12530792 0.28 LOH12CR1
 loss of heterozygosity, 12, chromosomal region 1
 20301
 0.16
chr11_14292192_14292493 0.28 RP11-21L19.1
2895
 0.33
chr8_43022838_43022989 0.28 HGSNAT
 heparan-alpha-glucosaminide N-acetyltransferase
 4548
 0.25
chr6_131522166_131522407 0.28 AKAP7
 A kinase (PRKA) anchor protein 7
 319
 0.94
chr22_22122978_22123169 0.28 ENSG00000200985
 .
 23650
 0.12
chr21_28173546_28173697 0.27 ADAMTS1
 ADAM metallopeptidase with thrombospondin type 1 motif, 1
 41716
 0.19
chr5_106820984_106821135 0.27 EFNA5
 ephrin-A5
 185269
 0.03
chr17_81011389_81011616 0.27 B3GNTL1
 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1
 1816
 0.39
chr7_130787419_130787695 0.27 LINC-PINT
 long intergenic non-protein coding RNA, p53 induced transcript
 4232
 0.24
chr5_75772499_75772650 0.27 IQGAP2
 IQ motif containing GTPase activating protein 2
 70660
 0.11
chrX_154610322_154610473 0.27 H2AFB2
 H2A histone family, member B2
 31
 0.95
chr6_156721216_156721434 0.26 ENSG00000212295
 .
 21441
 0.29
chr17_40335110_40335456 0.26 KCNH4
 potassium voltage-gated channel, subfamily H (eag-related), member 4
 1987
 0.17
chr5_118654684_118654873 0.26 ENSG00000243333
 .
 12452
 0.19
chr1_235409251_235409407 0.26 ARID4B
 AT rich interactive domain 4B (RBP1-like)
 32098
 0.15
chr16_84793876_84794027 0.26 USP10
 ubiquitin specific peptidase 10
 7920
 0.22
chr4_109064231_109064426 0.26 LEF1
 lymphoid enhancer-binding factor 1
 23129
 0.2
chr8_28917857_28918302 0.26 CTD-2647L4.4
4627
 0.16
chr12_90066993_90067399 0.26 ATP2B1
 ATPase, Ca++ transporting, plasma membrane 1
 17308
 0.2
chr11_47554537_47554716 0.26 CELF1
 CUGBP, Elav-like family member 1
 8293
 0.09
chr17_39463548_39463699 0.26 KRTAP16-1
 keratin associated protein 16-1
 1882
 0.16
chr1_115293004_115293155 0.26 CSDE1
 cold shock domain containing E1, RNA-binding
 268
 0.89
chr2_135019389_135019651 0.26 MGAT5
 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase
 7690
 0.26
chr16_16168105_16168644 0.25 ABCC1
 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
 64661
 0.11
chr5_156711613_156711855 0.25 CYFIP2
 cytoplasmic FMR1 interacting protein 2
 638
 0.67
chr9_33147549_33147791 0.25 RP11-326F20.5
19303
 0.14
chr11_114042089_114042401 0.25 ENSG00000221112
 .
 84594
 0.08
chr2_135681619_135681893 0.25 CCNT2
 cyclin T2
 5361
 0.2
chr6_16477083_16477234 0.25 ENSG00000265642
 .
 48404
 0.19
chr13_22148101_22148252 0.25 ENSG00000207518
 .
 22627
 0.17
chr10_32643470_32643674 0.25 RP11-135A24.2
7247
 0.14
chr2_231361368_231362080 0.25 SP100
 SP100 nuclear antigen
 7253
 0.21
chr14_53207062_53207343 0.25 STYX
 serine/threonine/tyrosine interacting protein
 10302
 0.15
chr20_5754953_5755104 0.25 C20orf196
 chromosome 20 open reading frame 196
 23929
 0.22
chr3_167423246_167423397 0.25 PDCD10
 programmed cell death 10
 14565
 0.22
chr5_137901949_137902139 0.24 ENSG00000206989
 .
 5245
 0.14
chr20_13807011_13807162 0.24 NDUFAF5
 NADH dehydrogenase (ubiquinone) complex I, assembly factor 5
 41390
 0.16
chr8_129352283_129352543 0.24 ENSG00000201782
 .
 119663
 0.06
chr7_12298277_12298428 0.24 TMEM106B
 transmembrane protein 106B
 47403
 0.19
chr5_145247170_145247321 0.24 GRXCR2
 glutaredoxin, cysteine rich 2
 5286
 0.26
chr5_80039885_80040036 0.24 DHFR
 dihydrofolate reductase
 89158
 0.07
chr10_105671429_105671739 0.24 OBFC1
 oligonucleotide/oligosaccharide-binding fold containing 1
 5843
 0.19
chr4_1726361_1726512 0.24 TACC3
 transforming, acidic coiled-coil containing protein 3
 1599
 0.29
chr2_191327679_191327830 0.24 MFSD6
 major facilitator superfamily domain containing 6
 6465
 0.19
chr10_31673790_31673941 0.24 RP11-192P3.5
14817
 0.24
chr6_134736960_134737111 0.24 SGK1
 serum/glucocorticoid regulated kinase 1
 97785
 0.08
chr9_129747435_129747620 0.24 RALGPS1
 Ral GEF with PH domain and SH3 binding motif 1
 23023
 0.23
chr10_60097158_60097309 0.24 UBE2D1
 ubiquitin-conjugating enzyme E2D 1
 2498
 0.33
chr19_51728779_51728930 0.24 CD33
 CD33 molecule
 500
 0.64
chr16_53131442_53131593 0.24 CHD9
 chromodomain helicase DNA binding protein 9
 1555
 0.47
chr15_97280671_97280954 0.24 SPATA8-AS1
 SPATA8 antisense RNA 1 (head to head)
 44072
 0.16
chr13_74288455_74288993 0.24 KLF12
 Kruppel-like factor 12
 280462
 0.01
chr12_57464058_57464209 0.24 TMEM194A
 transmembrane protein 194A
 8413
 0.1
chrX_73828069_73828220 0.24 RLIM
 ring finger protein, LIM domain interacting
 6308
 0.26
chr2_26321481_26321632 0.24 ENSG00000199872
 .
 56012
 0.1
chr7_99740509_99740660 0.24 LAMTOR4
 late endosomal/lysosomal adaptor, MAPK and MTOR activator 4
 5946
 0.06
chr13_32422165_32422316 0.24 EEF1DP3
 eukaryotic translation elongation factor 1 delta pseudogene 3
 104477
 0.07
chr15_81576710_81577129 0.24 IL16
 interleukin 16
 12335
 0.21
chr10_76768588_76768925 0.24 RP11-77G23.5
15253
 0.18
chrX_13068365_13068668 0.24 FAM9C
 family with sequence similarity 9, member C
 5715
 0.29
chr5_150602171_150602425 0.24 CCDC69
 coiled-coil domain containing 69
 1408
 0.42
chr14_55755286_55755437 0.23 FBXO34
 F-box protein 34
 16489
 0.22
chr8_16212479_16212630 0.23 MSR1
 macrophage scavenger receptor 1
 139971
 0.05
chr22_31625213_31625942 0.23 ENSG00000202019
 .
 581
 0.61
chr2_158285091_158285242 0.23 CYTIP
 cytohesin 1 interacting protein
 10760
 0.22
chr20_23234110_23234261 0.23 ENSG00000201527
 .
 92577
 0.06
chr16_84744914_84745119 0.23 USP10
 ubiquitin specific peptidase 10
 11370
 0.21
chr1_153369255_153369406 0.23 S100A8
 S100 calcium binding protein A8
 5666
 0.12
chr5_138222832_138222983 0.23 CTNNA1
 catenin (cadherin-associated protein), alpha 1, 102kDa
 7023
 0.21
chr7_56175390_56175541 0.23 CHCHD2
 coiled-coil-helix-coiled-coil-helix domain containing 2
 1196
 0.33
chr1_183620793_183620944 0.23 APOBEC4
 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative)
 1580
 0.37
chr9_71144403_71144554 0.23 TMEM252
 transmembrane protein 252
 11305
 0.26
chr7_112581052_112581203 0.23 C7orf60
 chromosome 7 open reading frame 60
 1156
 0.64
chr5_96420083_96420234 0.23 CTD-2215E18.1
 Uncharacterized protein
 4621
 0.25
chr6_87869938_87870163 0.23 ZNF292
 zinc finger protein 292
 4711
 0.21
chr18_57023682_57023833 0.23 LMAN1
 lectin, mannose-binding, 1
 3437
 0.27
chr17_53975009_53975160 0.23 PCTP
 phosphatidylcholine transfer protein
 123987
 0.06
chrX_154689589_154689740 0.23 H2AFB3
 H2A histone family, member B3
 68
 0.94
chr5_73935242_73935400 0.23 HEXB
 hexosaminidase B (beta polypeptide)
 527
 0.69
chr14_39893718_39893961 0.23 FBXO33
 F-box protein 33
 7240
 0.26
chr3_148708308_148708510 0.23 GYG1
 glycogenin 1
 719
 0.69
chr13_99993452_99993845 0.23 ENSG00000207719
 .
 14737
 0.19
chr9_4967366_4967517 0.23 ENSG00000238362
 .
 656
 0.73
chr16_12443924_12444075 0.22 SNX29
 sorting nexin 29
 6111
 0.19
chr17_61721131_61721282 0.22 MAP3K3
 mitogen-activated protein kinase kinase kinase 3
 21136
 0.13
chr7_37468889_37469040 0.22 ENSG00000201566
 .
 5754
 0.2
chrX_49115275_49115491 0.22 FOXP3
 forkhead box P3
 314
 0.78
chr1_153885922_153886073 0.22 GATAD2B
 GATA zinc finger domain containing 2B
 9454
 0.11
chr6_90794400_90794673 0.22 ENSG00000222078
 .
 83311
 0.09
chr2_161191922_161192095 0.22 ENSG00000252465
 .
 61471
 0.12
chr9_104336672_104336823 0.22 PPP3R2
 protein phosphatase 3, regulatory subunit B, beta
 20536
 0.16
chr13_41571896_41572047 0.22 ELF1
 E74-like factor 1 (ets domain transcription factor)
 15553
 0.19
chr5_44809438_44809986 0.22 MRPS30
 mitochondrial ribosomal protein S30
 685
 0.52
chr3_176902587_176902738 0.22 TBL1XR1
 transducin (beta)-like 1 X-linked receptor 1
 11549
 0.25
chr6_144472861_144473147 0.22 STX11
 syntaxin 11
 1341
 0.54
chr12_65025056_65025207 0.22 RP11-338E21.2
3007
 0.17
chr12_16481710_16481861 0.22 MGST1
 microsomal glutathione S-transferase 1
 18291
 0.24
chr6_32819225_32819384 0.22 TAP1
 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
 1231
 0.29
chr3_141222680_141222888 0.22 RASA2
 RAS p21 protein activator 2
 16893
 0.2
chr17_33870045_33870196 0.22 SLFN12L
 schlafen family member 12-like
 5240
 0.12
chr22_40798855_40799170 0.22 SGSM3
 small G protein signaling modulator 3
 5305
 0.17
chr6_53200923_53201221 0.22 ELOVL5
 ELOVL fatty acid elongase 5
 12515
 0.2
chr4_15016877_15017028 0.22 CPEB2
 cytoplasmic polyadenylation element binding protein 2
 11392
 0.29
chr15_32651213_32651761 0.22 ENSG00000221444
 .
 34186
 0.1
chr11_78003689_78003840 0.22 RP11-452H21.1
32040
 0.15
chr3_141246984_141247135 0.22 RASA2-IT1
 RASA2 intronic transcript 1 (non-protein coding)
 3084
 0.31
chr5_177824468_177824619 0.22 ENSG00000242341
 .
 19618
 0.19
chr8_124038093_124038518 0.22 DERL1
 derlin 1
 293
 0.88
chr2_190424501_190424725 0.22 SLC40A1
 solute carrier family 40 (iron-regulated transporter), member 1
 21000
 0.22
chr8_64097015_64097166 0.22 YTHDF3
 YTH domain family, member 3
 2998
 0.33
chr12_112431054_112431322 0.21 TMEM116
 transmembrane protein 116
 12601
 0.16
chr7_104702521_104702736 0.21 KMT2E
 lysine (K)-specific methyltransferase 2E
 39290
 0.12
chr3_112678927_112679101 0.21 CD200R1
 CD200 receptor 1
 14745
 0.16
chr21_35570661_35571163 0.21 ENSG00000266007
 .
 106518
 0.06
chr8_87544233_87544384 0.21 CPNE3
 copine III
 3017
 0.27
chr1_75097390_75097541 0.21 C1orf173
 chromosome 1 open reading frame 173
 3074
 0.3
chr10_97521369_97521820 0.21 ENTPD1
 ectonucleoside triphosphate diphosphohydrolase 1
 5880
 0.25
chr7_140084667_140084886 0.21 ENSG00000202472
 .
 1931
 0.24
chr1_229189673_229189824 0.21 RP5-1061H20.5
173561
 0.03

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

StringDB image

First level regulatory network of OVOL1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0032714 negative regulation of interleukin-5 production(GO:0032714)
0.1 0.3 GO:0031946 regulation of glucocorticoid biosynthetic process(GO:0031946)
0.1 0.3 GO:0001911 negative regulation of leukocyte mediated cytotoxicity(GO:0001911)
0.1 0.2 GO:0010040 response to iron(II) ion(GO:0010040)
0.1 0.3 GO:0001921 positive regulation of receptor recycling(GO:0001921)
0.1 0.3 GO:0032237 activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.1 0.2 GO:0030970 retrograde protein transport, ER to cytosol(GO:0030970)
0.0 0.2 GO:0060136 embryonic process involved in female pregnancy(GO:0060136)
0.0 0.1 GO:0045722 positive regulation of gluconeogenesis(GO:0045722)
0.0 0.2 GO:0010867 positive regulation of triglyceride biosynthetic process(GO:0010867)
0.0 0.2 GO:0006689 ganglioside catabolic process(GO:0006689)
0.0 0.1 GO:0000019 regulation of mitotic recombination(GO:0000019)
0.0 0.2 GO:0019985 translesion synthesis(GO:0019985)
0.0 0.3 GO:0006491 N-glycan processing(GO:0006491)
0.0 0.2 GO:0046642 negative regulation of alpha-beta T cell proliferation(GO:0046642)
0.0 0.0 GO:0002448 mast cell mediated immunity(GO:0002448)
0.0 0.1 GO:0042091 interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.0 0.2 GO:0032875 regulation of DNA endoreduplication(GO:0032875) negative regulation of DNA endoreduplication(GO:0032876) DNA endoreduplication(GO:0042023)
0.0 0.1 GO:0033152 immunoglobulin V(D)J recombination(GO:0033152)
0.0 0.1 GO:0042996 regulation of Golgi to plasma membrane protein transport(GO:0042996)
0.0 0.1 GO:0050857 positive regulation of antigen receptor-mediated signaling pathway(GO:0050857)
0.0 0.2 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.0 0.1 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.0 0.1 GO:0032486 Rap protein signal transduction(GO:0032486)
0.0 0.2 GO:0002335 mature B cell differentiation(GO:0002335)
0.0 0.1 GO:0034626 fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 0.1 GO:0071072 negative regulation of phospholipid biosynthetic process(GO:0071072)
0.0 0.1 GO:0035405 histone-threonine phosphorylation(GO:0035405)
0.0 0.1 GO:0045343 MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343)
0.0 0.1 GO:0045589 regulation of regulatory T cell differentiation(GO:0045589)
0.0 0.1 GO:0001821 histamine secretion(GO:0001821)
0.0 0.0 GO:0002664 T cell tolerance induction(GO:0002517) regulation of T cell tolerance induction(GO:0002664) positive regulation of T cell tolerance induction(GO:0002666)
0.0 0.2 GO:0042989 sequestering of actin monomers(GO:0042989)
0.0 0.1 GO:0060287 epithelial cilium movement(GO:0003351) epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
0.0 0.1 GO:0010572 positive regulation of platelet activation(GO:0010572)
0.0 0.1 GO:0071481 cellular response to X-ray(GO:0071481)
0.0 0.1 GO:0051409 response to nitrosative stress(GO:0051409)
0.0 0.1 GO:0045356 positive regulation of interferon-alpha biosynthetic process(GO:0045356)
0.0 0.2 GO:0007172 signal complex assembly(GO:0007172)
0.0 0.1 GO:0002483 antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.0 0.1 GO:0046007 negative regulation of activated T cell proliferation(GO:0046007)
0.0 0.1 GO:0002523 leukocyte migration involved in inflammatory response(GO:0002523)
0.0 0.1 GO:0006772 thiamine metabolic process(GO:0006772)
0.0 0.2 GO:0006477 protein sulfation(GO:0006477)
0.0 0.1 GO:0032506 cytokinetic process(GO:0032506)
0.0 0.1 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.0 0.0 GO:0002326 B cell lineage commitment(GO:0002326)
0.0 0.1 GO:0045003 DNA recombinase assembly(GO:0000730) double-strand break repair via synthesis-dependent strand annealing(GO:0045003)
0.0 0.1 GO:0002713 negative regulation of B cell mediated immunity(GO:0002713) negative regulation of immunoglobulin mediated immune response(GO:0002890)
0.0 0.0 GO:0032785 negative regulation of DNA-templated transcription, elongation(GO:0032785) negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244)
0.0 0.0 GO:0002323 natural killer cell activation involved in immune response(GO:0002323) natural killer cell degranulation(GO:0043320)
0.0 0.1 GO:0006167 AMP biosynthetic process(GO:0006167)
0.0 0.1 GO:0018076 N-terminal peptidyl-lysine acetylation(GO:0018076)
0.0 0.0 GO:0001743 optic placode formation(GO:0001743)
0.0 0.1 GO:0060049 regulation of protein glycosylation(GO:0060049)
0.0 0.1 GO:0032211 negative regulation of telomere maintenance via telomerase(GO:0032211)
0.0 0.1 GO:0021554 optic nerve development(GO:0021554)
0.0 0.0 GO:0033160 positive regulation of protein import into nucleus, translocation(GO:0033160)
0.0 0.3 GO:0050853 B cell receptor signaling pathway(GO:0050853)
0.0 0.0 GO:0046101 hypoxanthine biosynthetic process(GO:0046101)
0.0 0.1 GO:0050856 regulation of T cell receptor signaling pathway(GO:0050856)
0.0 0.1 GO:0000042 protein targeting to Golgi(GO:0000042) establishment of protein localization to Golgi(GO:0072600)
0.0 0.1 GO:0007406 negative regulation of neuroblast proliferation(GO:0007406) negative regulation of neural precursor cell proliferation(GO:2000178)
0.0 0.1 GO:0035520 monoubiquitinated protein deubiquitination(GO:0035520)
0.0 0.1 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
0.0 0.1 GO:0032922 circadian regulation of gene expression(GO:0032922)
0.0 0.0 GO:0006534 cysteine metabolic process(GO:0006534)
0.0 0.1 GO:0051712 positive regulation of killing of cells of other organism(GO:0051712)
0.0 0.0 GO:0001672 regulation of chromatin assembly or disassembly(GO:0001672)
0.0 0.4 GO:0006611 protein export from nucleus(GO:0006611)
0.0 0.1 GO:0046827 positive regulation of protein export from nucleus(GO:0046827)
0.0 0.1 GO:0060123 regulation of growth hormone secretion(GO:0060123)
0.0 0.1 GO:0036465 synaptic vesicle recycling(GO:0036465) synaptic vesicle endocytosis(GO:0048488) clathrin-mediated endocytosis(GO:0072583)
0.0 0.1 GO:1901797 negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518) negative regulation of signal transduction by p53 class mediator(GO:1901797)
0.0 0.1 GO:0006290 pyrimidine dimer repair(GO:0006290)
0.0 0.0 GO:0051971 positive regulation of transmission of nerve impulse(GO:0051971)
0.0 0.0 GO:0045603 positive regulation of endothelial cell differentiation(GO:0045603)
0.0 0.1 GO:0090286 cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.0 0.1 GO:0001820 serotonin secretion(GO:0001820)
0.0 0.1 GO:0031125 rRNA 3'-end processing(GO:0031125)
0.0 0.1 GO:0042339 keratan sulfate metabolic process(GO:0042339)
0.0 0.1 GO:0008295 spermidine biosynthetic process(GO:0008295)
0.0 0.0 GO:0009048 dosage compensation by inactivation of X chromosome(GO:0009048)
0.0 0.1 GO:0048496 maintenance of organ identity(GO:0048496)
0.0 0.1 GO:0015917 aminophospholipid transport(GO:0015917)
0.0 0.5 GO:0050690 regulation of defense response to virus by virus(GO:0050690)
0.0 0.4 GO:0045576 mast cell activation(GO:0045576)
0.0 0.1 GO:0002823 negative regulation of adaptive immune response(GO:0002820) negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains(GO:0002823)
0.0 0.1 GO:1904035 endothelial cell apoptotic process(GO:0072577) epithelial cell apoptotic process(GO:1904019) regulation of epithelial cell apoptotic process(GO:1904035) regulation of endothelial cell apoptotic process(GO:2000351)
0.0 0.1 GO:0008588 release of cytoplasmic sequestered NF-kappaB(GO:0008588)
0.0 0.1 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.0 0.2 GO:0044409 entry into host cell(GO:0030260) entry into host(GO:0044409) entry into cell of other organism involved in symbiotic interaction(GO:0051806) entry into other organism involved in symbiotic interaction(GO:0051828)
0.0 0.0 GO:0040016 embryonic cleavage(GO:0040016)
0.0 0.2 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.0 0.0 GO:0007549 dosage compensation(GO:0007549)
0.0 0.1 GO:0071803 regulation of podosome assembly(GO:0071801) positive regulation of podosome assembly(GO:0071803)
0.0 0.1 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.0 0.1 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 0.1 GO:0070723 response to sterol(GO:0036314) response to cholesterol(GO:0070723)
0.0 0.2 GO:0032456 endocytic recycling(GO:0032456)
0.0 0.1 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.0 0.1 GO:0021548 pons development(GO:0021548)
0.0 0.1 GO:0034063 stress granule assembly(GO:0034063)
0.0 0.1 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0 0.1 GO:0055009 atrial cardiac muscle tissue development(GO:0003228) atrial cardiac muscle tissue morphogenesis(GO:0055009)
0.0 0.0 GO:0021561 facial nerve development(GO:0021561)
0.0 0.1 GO:0050710 negative regulation of cytokine secretion(GO:0050710)
0.0 0.0 GO:0046599 regulation of centriole replication(GO:0046599)
0.0 0.0 GO:0002248 wound healing involved in inflammatory response(GO:0002246) connective tissue replacement involved in inflammatory response wound healing(GO:0002248) inflammatory response to wounding(GO:0090594) connective tissue replacement(GO:0097709)
0.0 0.1 GO:0045059 positive thymic T cell selection(GO:0045059)
0.0 0.0 GO:0060058 apoptotic process involved in mammary gland involution(GO:0060057) positive regulation of apoptotic process involved in mammary gland involution(GO:0060058) positive regulation of apoptotic process involved in morphogenesis(GO:1902339) regulation of mammary gland involution(GO:1903519) positive regulation of mammary gland involution(GO:1903521) positive regulation of apoptotic process involved in development(GO:1904747)
0.0 0.1 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.0 0.0 GO:0070208 protein heterotrimerization(GO:0070208)
0.0 0.1 GO:0000012 single strand break repair(GO:0000012)
0.0 0.2 GO:0045648 positive regulation of erythrocyte differentiation(GO:0045648)
0.0 0.1 GO:0031936 negative regulation of chromatin silencing(GO:0031936)
0.0 0.0 GO:0033629 negative regulation of cell adhesion mediated by integrin(GO:0033629)
0.0 0.1 GO:0045084 positive regulation of interleukin-12 biosynthetic process(GO:0045084)
0.0 0.1 GO:0007252 I-kappaB phosphorylation(GO:0007252)
0.0 0.0 GO:0035609 C-terminal protein deglutamylation(GO:0035609) protein side chain deglutamylation(GO:0035610)
0.0 0.0 GO:0001302 replicative cell aging(GO:0001302)
0.0 0.1 GO:0022027 interkinetic nuclear migration(GO:0022027)
0.0 0.0 GO:0016242 negative regulation of macroautophagy(GO:0016242)
0.0 0.1 GO:0002726 positive regulation of T cell cytokine production(GO:0002726)
0.0 0.1 GO:0032469 endoplasmic reticulum calcium ion homeostasis(GO:0032469)
0.0 0.0 GO:0061526 acetylcholine secretion, neurotransmission(GO:0014055) regulation of acetylcholine secretion, neurotransmission(GO:0014056) acetylcholine secretion(GO:0061526)
0.0 0.1 GO:0019673 GDP-mannose metabolic process(GO:0019673)
0.0 0.0 GO:0051305 chromosome movement towards spindle pole(GO:0051305)
0.0 0.1 GO:0019987 obsolete negative regulation of anti-apoptosis(GO:0019987)
0.0 0.1 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 0.0 GO:0016999 antibiotic metabolic process(GO:0016999) antibiotic biosynthetic process(GO:0017000)
0.0 0.0 GO:0001766 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.0 0.0 GO:0070682 proteasome regulatory particle assembly(GO:0070682)
0.0 0.1 GO:0033194 response to hydroperoxide(GO:0033194)
0.0 0.1 GO:0017182 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.0 0.1 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.0 0.0 GO:0051152 positive regulation of smooth muscle cell differentiation(GO:0051152)
0.0 0.0 GO:0032927 positive regulation of activin receptor signaling pathway(GO:0032927)
0.0 0.0 GO:0090075 relaxation of muscle(GO:0090075)
0.0 0.1 GO:0046884 follicle-stimulating hormone secretion(GO:0046884)
0.0 0.2 GO:0007076 mitotic chromosome condensation(GO:0007076)
0.0 0.0 GO:0071288 cellular response to mercury ion(GO:0071288)
0.0 0.0 GO:0051451 myoblast migration(GO:0051451)
0.0 0.0 GO:0017121 phospholipid scrambling(GO:0017121)
0.0 0.0 GO:2001021 negative regulation of response to DNA damage stimulus(GO:2001021)
0.0 0.1 GO:0072526 pyridine-containing compound catabolic process(GO:0072526)
0.0 0.1 GO:0008218 bioluminescence(GO:0008218)
0.0 0.1 GO:0070536 protein K63-linked deubiquitination(GO:0070536)
0.0 0.0 GO:0032210 regulation of telomere maintenance via telomerase(GO:0032210)
0.0 0.1 GO:0044091 membrane biogenesis(GO:0044091)
0.0 0.1 GO:0000098 sulfur amino acid catabolic process(GO:0000098)
0.0 0.0 GO:0008298 intracellular mRNA localization(GO:0008298)
0.0 0.1 GO:0018345 protein palmitoylation(GO:0018345)
0.0 0.1 GO:0042135 neurotransmitter catabolic process(GO:0042135)
0.0 0.0 GO:0050765 negative regulation of phagocytosis(GO:0050765)
0.0 0.0 GO:0050667 homocysteine metabolic process(GO:0050667)
0.0 0.0 GO:0070493 thrombin receptor signaling pathway(GO:0070493)
0.0 0.0 GO:0043369 CD4-positive or CD8-positive, alpha-beta T cell lineage commitment(GO:0043369)
0.0 0.0 GO:0002430 complement receptor mediated signaling pathway(GO:0002430)
0.0 0.0 GO:0051584 regulation of neurotransmitter uptake(GO:0051580) regulation of dopamine uptake involved in synaptic transmission(GO:0051584) regulation of catecholamine uptake involved in synaptic transmission(GO:0051940)
0.0 0.0 GO:0051533 positive regulation of NFAT protein import into nucleus(GO:0051533)
0.0 0.0 GO:0006434 seryl-tRNA aminoacylation(GO:0006434)
0.0 0.1 GO:0043268 positive regulation of potassium ion transport(GO:0043268)
0.0 0.1 GO:0042119 neutrophil activation(GO:0042119)
0.0 0.0 GO:0042732 D-xylose metabolic process(GO:0042732)
0.0 0.1 GO:0008608 attachment of spindle microtubules to kinetochore(GO:0008608)
0.0 0.0 GO:1902101 positive regulation of mitotic metaphase/anaphase transition(GO:0045842) positive regulation of mitotic sister chromatid separation(GO:1901970) positive regulation of metaphase/anaphase transition of cell cycle(GO:1902101)
0.0 0.1 GO:0000380 alternative mRNA splicing, via spliceosome(GO:0000380)
0.0 0.1 GO:0046149 porphyrin-containing compound catabolic process(GO:0006787) tetrapyrrole catabolic process(GO:0033015) heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149)
0.0 0.1 GO:0070498 interleukin-1-mediated signaling pathway(GO:0070498)
0.0 0.0 GO:0043248 proteasome assembly(GO:0043248)
0.0 0.1 GO:0050930 induction of positive chemotaxis(GO:0050930)
0.0 0.0 GO:0007195 adenylate cyclase-inhibiting dopamine receptor signaling pathway(GO:0007195)
0.0 0.1 GO:0071501 response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.0 0.5 GO:0050852 T cell receptor signaling pathway(GO:0050852)
0.0 0.1 GO:0016572 histone phosphorylation(GO:0016572)
0.0 0.1 GO:0045745 positive regulation of G-protein coupled receptor protein signaling pathway(GO:0045745)
0.0 0.0 GO:0090598 male genitalia morphogenesis(GO:0048808) male anatomical structure morphogenesis(GO:0090598)
0.0 0.0 GO:0021778 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) oligodendrocyte cell fate specification(GO:0021778) glial cell fate specification(GO:0021780)
0.0 0.3 GO:0050772 positive regulation of axonogenesis(GO:0050772)
0.0 0.0 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.0 0.0 GO:0002579 positive regulation of antigen processing and presentation(GO:0002579) positive regulation of dendritic cell antigen processing and presentation(GO:0002606)
0.0 0.0 GO:0006530 asparagine catabolic process(GO:0006530) asparagine catabolic process via L-aspartate(GO:0033345)
0.0 0.1 GO:0046541 saliva secretion(GO:0046541)
0.0 0.0 GO:0015801 aromatic amino acid transport(GO:0015801)
0.0 0.1 GO:0050691 regulation of defense response to virus by host(GO:0050691)
0.0 0.0 GO:0030889 negative regulation of B cell proliferation(GO:0030889)
0.0 0.0 GO:0009051 pentose-phosphate shunt, oxidative branch(GO:0009051)
0.0 0.0 GO:0016576 histone dephosphorylation(GO:0016576)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0042629 mast cell granule(GO:0042629)
0.0 0.1 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.0 0.1 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0 0.3 GO:0034362 low-density lipoprotein particle(GO:0034362)
0.0 0.2 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.3 GO:0001772 immunological synapse(GO:0001772)
0.0 0.2 GO:0005662 DNA replication factor A complex(GO:0005662)
0.0 0.1 GO:0000137 Golgi cis cisterna(GO:0000137)
0.0 0.0 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.0 0.1 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 0.1 GO:0000800 lateral element(GO:0000800)
0.0 0.1 GO:0000300 obsolete peripheral to membrane of membrane fraction(GO:0000300)
0.0 0.0 GO:0031313 extrinsic component of vacuolar membrane(GO:0000306) extrinsic component of endosome membrane(GO:0031313)
0.0 0.1 GO:0005719 nuclear euchromatin(GO:0005719)
0.0 0.1 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 0.2 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 0.1 GO:0070188 obsolete Stn1-Ten1 complex(GO:0070188)
0.0 0.1 GO:0042101 T cell receptor complex(GO:0042101)
0.0 0.1 GO:0032449 CBM complex(GO:0032449)
0.0 0.1 GO:0045179 apical cortex(GO:0045179)
0.0 0.1 GO:0000942 condensed nuclear chromosome outer kinetochore(GO:0000942)
0.0 0.2 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.1 GO:0000796 condensin complex(GO:0000796)
0.0 0.0 GO:0002141 stereocilia coupling link(GO:0002139) stereocilia ankle link(GO:0002141) stereocilia ankle link complex(GO:0002142)
0.0 0.1 GO:0030673 axolemma(GO:0030673)
0.0 0.0 GO:0071942 XPC complex(GO:0071942)
0.0 0.1 GO:0016342 catenin complex(GO:0016342)
0.0 0.1 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 0.0 GO:0032009 early phagosome(GO:0032009)
0.0 0.0 GO:0005787 signal peptidase complex(GO:0005787)
0.0 0.2 GO:0032300 mismatch repair complex(GO:0032300)
0.0 0.1 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.0 0.1 GO:0030312 external encapsulating structure(GO:0030312)
0.0 0.1 GO:0005682 U5 snRNP(GO:0005682)
0.0 0.1 GO:0030904 retromer complex(GO:0030904)
0.0 0.3 GO:0031201 SNARE complex(GO:0031201)
0.0 0.3 GO:0016328 lateral plasma membrane(GO:0016328)
0.0 0.1 GO:0016471 vacuolar proton-transporting V-type ATPase complex(GO:0016471)
0.0 0.1 GO:0042825 TAP complex(GO:0042825)
0.0 0.0 GO:0030934 anchoring collagen complex(GO:0030934)
0.0 0.0 GO:0031312 extrinsic component of organelle membrane(GO:0031312)
0.0 0.0 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.0 0.0 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.0 0.1 GO:0071204 histone pre-mRNA 3'end processing complex(GO:0071204)
0.0 0.1 GO:0000145 exocyst(GO:0000145)
0.0 0.1 GO:0031527 filopodium membrane(GO:0031527)
0.0 0.1 GO:0030870 Mre11 complex(GO:0030870)
0.0 0.1 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 0.0 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.0 0.1 GO:0042575 DNA polymerase complex(GO:0042575)
0.0 0.0 GO:0001652 granular component(GO:0001652)
0.0 0.0 GO:0005826 actomyosin contractile ring(GO:0005826)
0.0 0.1 GO:0042382 paraspeckles(GO:0042382)
0.0 0.0 GO:0005947 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947)
0.0 0.1 GO:0045275 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.1 0.2 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0 0.1 GO:0033691 sialic acid binding(GO:0033691)
0.0 0.3 GO:0004908 interleukin-1 receptor activity(GO:0004908)
0.0 0.2 GO:0030284 estrogen receptor activity(GO:0030284)
0.0 0.1 GO:0035184 histone threonine kinase activity(GO:0035184)
0.0 0.1 GO:0016509 long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0016509)
0.0 0.1 GO:0016842 amidine-lyase activity(GO:0016842)
0.0 0.2 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.0 0.1 GO:0030375 thyroid hormone receptor coactivator activity(GO:0030375)
0.0 0.2 GO:0016494 C-X-C chemokine receptor activity(GO:0016494)
0.0 0.1 GO:0070053 thrombospondin receptor activity(GO:0070053)
0.0 0.3 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.0 0.1 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.0 0.1 GO:0004311 farnesyltranstransferase activity(GO:0004311)
0.0 0.2 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.0 0.1 GO:0004321 fatty-acyl-CoA synthase activity(GO:0004321)
0.0 0.3 GO:0042288 MHC class I protein binding(GO:0042288)
0.0 0.3 GO:0030169 low-density lipoprotein particle binding(GO:0030169)
0.0 0.1 GO:0070087 chromo shadow domain binding(GO:0070087)
0.0 0.3 GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906)
0.0 0.0 GO:0032139 dinucleotide insertion or deletion binding(GO:0032139)
0.0 0.2 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0 0.1 GO:0098847 single-stranded telomeric DNA binding(GO:0043047) sequence-specific single stranded DNA binding(GO:0098847)
0.0 0.1 GO:0051880 G-quadruplex DNA binding(GO:0051880)
0.0 0.1 GO:0036002 pre-mRNA binding(GO:0036002)
0.0 0.0 GO:0050253 retinyl-palmitate esterase activity(GO:0050253)
0.0 0.1 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.0 0.1 GO:0047238 glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.0 0.1 GO:0032552 deoxyribonucleotide binding(GO:0032552)
0.0 0.1 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0 0.1 GO:0002060 purine nucleobase binding(GO:0002060)
0.0 0.3 GO:0019198 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0 0.1 GO:0004948 calcitonin receptor activity(GO:0004948)
0.0 0.2 GO:0004467 long-chain fatty acid-CoA ligase activity(GO:0004467)
0.0 0.1 GO:0070097 delta-catenin binding(GO:0070097)
0.0 0.1 GO:0003909 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.0 0.1 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 0.1 GO:0008900 hydrogen:potassium-exchanging ATPase activity(GO:0008900)
0.0 0.1 GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517)
0.0 0.1 GO:0032137 guanine/thymine mispair binding(GO:0032137)
0.0 0.1 GO:0001758 retinal dehydrogenase activity(GO:0001758)
0.0 0.1 GO:0000064 L-ornithine transmembrane transporter activity(GO:0000064)
0.0 0.1 GO:0016520 growth hormone-releasing hormone receptor activity(GO:0016520)
0.0 0.1 GO:0003696 satellite DNA binding(GO:0003696)
0.0 0.1 GO:0003747 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.0 0.0 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0 0.0 GO:0003953 NAD+ nucleosidase activity(GO:0003953)
0.0 0.0 GO:0035197 siRNA binding(GO:0035197)
0.0 0.1 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0 0.0 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0 0.1 GO:0043422 protein kinase B binding(GO:0043422)
0.0 0.2 GO:0051018 protein kinase A binding(GO:0051018)
0.0 0.1 GO:0043208 glycosphingolipid binding(GO:0043208)
0.0 0.0 GO:0015645 fatty acid ligase activity(GO:0015645)
0.0 0.1 GO:0016778 diphosphotransferase activity(GO:0016778)
0.0 0.1 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 0.0 GO:0032450 maltose alpha-glucosidase activity(GO:0032450)
0.0 0.2 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.0 0.1 GO:0016493 C-C chemokine receptor activity(GO:0016493)
0.0 0.1 GO:0005522 profilin binding(GO:0005522)
0.0 0.5 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.0 0.1 GO:0048018 receptor agonist activity(GO:0048018)
0.0 0.1 GO:0004969 histamine receptor activity(GO:0004969)
0.0 0.1 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.0 0.1 GO:0008504 monoamine transmembrane transporter activity(GO:0008504)
0.0 0.5 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.1 GO:0009922 fatty acid elongase activity(GO:0009922)
0.0 0.1 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.0 0.0 GO:0008898 S-adenosylmethionine-homocysteine S-methyltransferase activity(GO:0008898)
0.0 0.0 GO:0004677 DNA-dependent protein kinase activity(GO:0004677)
0.0 0.0 GO:0010521 telomerase inhibitor activity(GO:0010521)
0.0 0.0 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.0 0.2 GO:0016896 exoribonuclease activity, producing 5'-phosphomonoesters(GO:0016896)
0.0 0.6 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 0.1 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.0 0.1 GO:0034713 type I transforming growth factor beta receptor binding(GO:0034713)
0.0 0.1 GO:0016417 S-acyltransferase activity(GO:0016417)
0.0 0.0 GO:0016748 succinyltransferase activity(GO:0016748)
0.0 0.0 GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.0 0.2 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 0.2 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.0 GO:0015245 fatty acid transporter activity(GO:0015245)
0.0 0.1 GO:0030742 GTP-dependent protein binding(GO:0030742)
0.0 0.0 GO:0004875 complement receptor activity(GO:0004875)
0.0 0.0 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.0 GO:0004828 serine-tRNA ligase activity(GO:0004828)
0.0 0.0 GO:0019958 C-X-C chemokine binding(GO:0019958) interleukin-8 binding(GO:0019959)
0.0 0.0 GO:0050897 cobalt ion binding(GO:0050897)
0.0 0.0 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.0 0.2 GO:0005246 calcium channel regulator activity(GO:0005246)
0.0 0.1 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.0 0.1 GO:0031434 mitogen-activated protein kinase kinase binding(GO:0031434)
0.0 0.1 GO:0031210 phosphatidylcholine binding(GO:0031210)
0.0 0.1 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 0.1 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029)
0.0 0.1 GO:0004704 NF-kappaB-inducing kinase activity(GO:0004704)
0.0 0.0 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.0 PID CXCR3 PATHWAY CXCR3-mediated signaling events
0.0 1.4 PID CD8 TCR PATHWAY TCR signaling in naïve CD8+ T cells
0.0 0.3 PID IL5 PATHWAY IL5-mediated signaling events
0.0 0.3 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.4 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.0 0.2 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 0.3 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.0 0.0 PID FAS PATHWAY FAS (CD95) signaling pathway
0.0 0.2 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.0 0.6 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 0.4 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events
0.0 0.1 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 0.3 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.0 0.6 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.0 0.5 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 0.0 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 0.1 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.0 0.0 PID ERBB4 PATHWAY ErbB4 signaling events
0.0 0.0 PID TXA2PATHWAY Thromboxane A2 receptor signaling
0.0 0.3 PID BCR 5PATHWAY BCR signaling pathway
0.0 0.3 PID CDC42 REG PATHWAY Regulation of CDC42 activity

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.0 REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.0 0.5 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.0 0.4 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.0 0.4 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0 0.1 REACTOME PECAM1 INTERACTIONS Genes involved in PECAM1 interactions
0.0 0.3 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 0.3 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.0 0.1 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
0.0 0.5 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0 0.3 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.0 REACTOME SCFSKP2 MEDIATED DEGRADATION OF P27 P21 Genes involved in SCF(Skp2)-mediated degradation of p27/p21
0.0 0.1 REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.0 0.1 REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G Genes involved in Vif-mediated degradation of APOBEC3G
0.0 0.2 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.0 0.1 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.0 0.2 REACTOME TCR SIGNALING Genes involved in TCR signaling
0.0 0.0 REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
0.0 0.1 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 0.1 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
0.0 0.1 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex
0.0 0.3 REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.0 0.2 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 0.3 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 0.0 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.0 0.2 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 0.1 REACTOME DESTABILIZATION OF MRNA BY KSRP Genes involved in Destabilization of mRNA by KSRP
0.0 0.2 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.2 REACTOME DESTABILIZATION OF MRNA BY BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.0 0.2 REACTOME GPVI MEDIATED ACTIVATION CASCADE Genes involved in GPVI-mediated activation cascade
0.0 0.1 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.0 0.3 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression