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ENCODE: H3K4me1 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for PAX1_PAX9

Z-value: 1.32

Motif logo

Transcription factors associated with PAX1_PAX9

Gene Symbol	Gene ID	Gene Info
PAX1 Ensembl NCBI GeneCards UniProt	ENSG00000125813.9	PAX1
PAX9 Ensembl NCBI GeneCards UniProt	ENSG00000198807.8	PAX9

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
PAX1	chr20_21684553_21684704	1669	0.534097	0.89	1.3e-03	Click!
PAX1	chr20_21964047_21964198	277261	0.014993	-0.82	6.4e-03	Click!
PAX1	chr20_21683420_21683692	2741	0.412695	0.79	1.1e-02	Click!
PAX1	chr20_21962216_21962367	275430	0.015182	-0.72	2.7e-02	Click!
PAX1	chr20_21963068_21963219	276282	0.015094	-0.70	3.6e-02	Click!
PAX9	chr14_37126012_37126279	628	0.670083	0.75	1.9e-02	Click!
PAX9	chr14_37125770_37125921	928	0.526575	0.74	2.4e-02	Click!
PAX9	chr14_37127166_37127317	468	0.622511	0.70	3.6e-02	Click!
PAX9	chr14_37126657_37126808	41	0.962722	0.68	4.5e-02	Click!
PAX9	chr14_37133644_37133795	1940	0.325598	0.65	5.7e-02	Click!

Activity of the PAX1_PAX9 motif across conditions

Conditions sorted by the z-value of the PAX1_PAX9 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr13_76210517_76210668	0.92	LMO7	LIM domain 7	133	0.82
chr14_103852606_103852757	0.88	MARK3	MAP/microtubule affinity-regulating kinase 3	105	0.96
chr2_70367797_70368219	0.84	C2orf42	chromosome 2 open reading frame 42	41119	0.11
chr11_62405884_62406075	0.81	GANAB	glucosidase, alpha; neutral AB	8102	0.06
chr3_152880548_152880699	0.81	RAP2B	RAP2B, member of RAS oncogene family	594	0.63
chr6_5626865_5627048	0.80	RP1-256G22.2		68549	0.13
chr18_77707966_77708117	0.78	PQLC1	PQ loop repeat containing 1	2776	0.26
chr5_133747815_133748037	0.75	CDKN2AIPNL	CDKN2A interacting protein N-terminal like	337	0.86
chr21_47012638_47012829	0.73	SLC19A1	solute carrier family 19 (folate transporter), member 1	48408	0.13
chr7_64348404_64348555	0.72	RP11-797H7.5		1999	0.34
chr6_130349340_130349950	0.71	L3MBTL3	l(3)mbt-like 3 (Drosophila)	7943	0.29
chr7_149471850_149472001	0.71	ZNF467	zinc finger protein 467	1357	0.47
chr15_70007265_70007861	0.71	ENSG00000238870	.	15598	0.26
chr2_120967451_120967637	0.69	AC012363.4		6576	0.18
chr17_28076156_28076317	0.67	RP11-82O19.1		11885	0.16
chr14_21560524_21560677	0.64	ZNF219	zinc finger protein 219	1387	0.24
chr8_82101889_82102084	0.63	PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	77683	0.1
chr5_36875594_36875785	0.62	NIPBL	Nipped-B homolog (Drosophila)	1172	0.65
chr5_157030982_157031230	0.61	ENSG00000252068	.	24601	0.13
chr4_4856521_4856672	0.60	MSX1	msh homeobox 1	4797	0.31
chr16_85450287_85450438	0.59	ENSG00000264203	.	24736	0.21
chr2_43397324_43397558	0.59	ZFP36L2	ZFP36 ring finger protein-like 2	56307	0.13
chr20_35257246_35257397	0.59	SLA2	Src-like-adaptor 2	16963	0.12
chr1_44890754_44890905	0.59	RNF220	ring finger protein 220	1117	0.52
chr7_102072169_102072320	0.57	ORAI2	ORAI calcium release-activated calcium modulator 2	1309	0.24
chr2_202899288_202899439	0.55	FZD7	frizzled family receptor 7	53	0.97
chr2_33823948_33824099	0.54	FAM98A	family with sequence similarity 98, member A	321	0.92
chr9_140173644_140173795	0.54	TOR4A	torsin family 4, member A	1518	0.19
chr2_431196_431347	0.54	FAM150B	family with sequence similarity 150, member B	142420	0.04
chr16_68026491_68026784	0.53	DPEP2	dipeptidase 2	1129	0.26
chr13_48809535_48809778	0.53	ITM2B	integral membrane protein 2B	2317	0.39
chr11_122714029_122714331	0.53	CRTAM	cytotoxic and regulatory T cell molecule	4972	0.24
chr4_85888517_85888668	0.52	WDFY3	WD repeat and FYVE domain containing 3	1048	0.66
chr19_49376384_49376535	0.52	PPP1R15A	protein phosphatase 1, regulatory subunit 15A	810	0.4
chr16_4585585_4585736	0.52	CDIP1	cell death-inducing p53 target 1	2745	0.18
chr5_177632572_177632811	0.51	HNRNPAB	heterogeneous nuclear ribonucleoprotein A/B	1119	0.5
chr7_3083701_3083852	0.50	CARD11	caspase recruitment domain family, member 11	197	0.96
chr9_20271155_20271306	0.50	ENSG00000221744	.	23772	0.24
chr2_73495819_73495970	0.50	FBXO41	F-box protein 41	2149	0.23
chr3_152553837_152554068	0.49	P2RY1	purinergic receptor P2Y, G-protein coupled, 1	1216	0.65
chr9_73011935_73012121	0.49	KLF9	Kruppel-like factor 9	17512	0.25
chr2_182451424_182451575	0.49	CERKL	ceramide kinase-like	70234	0.11
chr19_10254387_10254800	0.48	EIF3G	eukaryotic translation initiation factor 3, subunit G	24015	0.07
chr10_11269625_11270026	0.48	RP3-323N1.2		56486	0.13
chr10_73078536_73078745	0.48	SLC29A3	solute carrier family 29 (equilibrative nucleoside transporter), member 3	375	0.87
chr20_33542964_33543246	0.47	GSS	glutathione synthetase	515	0.75
chr4_100742798_100742952	0.47	DAPP1	dual adaptor of phosphotyrosine and 3-phosphoinositides	4872	0.27
chr9_140340558_140340709	0.47	ENTPD8	ectonucleoside triphosphate diphosphohydrolase 8	4732	0.12
chr10_99393094_99393245	0.46	MORN4	MORN repeat containing 4	68	0.96
chr7_919296_919447	0.45	GET4	golgi to ER traffic protein 4 homolog (S. cerevisiae)	1829	0.27
chr11_43379396_43379615	0.45	TTC17	tetratricopeptide repeat domain 17	977	0.41
chr16_67197044_67197250	0.44	HSF4	heat shock transcription factor 4	141	0.87
chr2_219762742_219762992	0.44	WNT10A	wingless-type MMTV integration site family, member 10A	15984	0.1
chr2_227552176_227552327	0.44	ENSG00000263363	.	28742	0.23
chr6_35567353_35567706	0.44	ENSG00000212579	.	52066	0.1
chr2_131484016_131484249	0.43	GPR148	G protein-coupled receptor 148	2511	0.21
chr19_15528921_15529115	0.43	AKAP8L	A kinase (PRKA) anchor protein 8-like	781	0.53
chr2_234350927_234351078	0.43	USP40	ubiquitin specific peptidase 40	47105	0.11
chr14_24933172_24933323	0.43	SDR39U1	short chain dehydrogenase/reductase family 39U, member 1	21183	0.1
chr1_118201201_118201563	0.42	ENSG00000212266	.	29982	0.19
chr2_148257449_148257801	0.42	ENSG00000202074	.	4517	0.24
chrX_80065881_80066270	0.42	BRWD3	bromodomain and WD repeat domain containing 3	888	0.69
chr22_46038177_46038328	0.42	ENSG00000251985	.	17740	0.18
chr12_58128443_58128594	0.42	AGAP2	ArfGAP with GTPase domain, ankyrin repeat and PH domain 2	2906	0.09
chr5_140997623_140997787	0.41	AC008781.7		276	0.75
chr18_47813563_47813872	0.41	CXXC1	CXXC finger protein 1	223	0.92
chr2_68383804_68384020	0.41	WDR92	WD repeat domain 92	693	0.52
chr1_228678315_228678466	0.41	RNF187	ring finger protein 187	3628	0.1
chr21_34083416_34083567	0.41	SYNJ1	synaptojanin 1	15715	0.15
chr13_41163913_41164388	0.40	AL133318.1	Uncharacterized protein	52827	0.14
chr5_100237238_100237433	0.40	ST8SIA4	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4	1583	0.54
chr9_468550_468929	0.40	RP11-165F24.3		1063	0.4
chr10_76345115_76345367	0.39	ENSG00000206756	.	34091	0.2
chr3_151910786_151910994	0.39	MBNL1	muscleblind-like splicing regulator 1	74939	0.11
chr2_64957617_64958033	0.39	ENSG00000253082	.	45413	0.14
chr16_88638089_88638281	0.38	ZC3H18	zinc finger CCCH-type containing 18	1299	0.39
chr1_228674208_228674396	0.38	RNF187	ring finger protein 187	460	0.64
chr14_100068553_100068720	0.37	CCDC85C	coiled-coil domain containing 85C	1727	0.34
chr9_2028066_2028217	0.37	SMARCA2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	878	0.68
chr7_36429553_36429704	0.37	KIAA0895	KIAA0895	67	0.62
chr21_45559955_45560208	0.37	C21orf33	chromosome 21 open reading frame 33	4080	0.18
chr16_88764300_88764451	0.37	RP5-1142A6.5		1466	0.17
chr4_154709437_154709701	0.36	SFRP2	secreted frizzled-related protein 2	703	0.71
chr2_234329659_234329810	0.36	DGKD	diacylglycerol kinase, delta 130kDa	32934	0.14
chr8_8195680_8195853	0.36	SGK223	Tyrosine-protein kinase SgK223	43491	0.16
chr1_9787735_9787886	0.36	PIK3CD	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta	9683	0.17
chr14_68742179_68742813	0.35	ENSG00000243546	.	39240	0.2
chr14_105863891_105864106	0.35	TEX22	testis expressed 22	922	0.45
chr11_59538487_59538638	0.35	STX3	syntaxin 3	15637	0.13
chr10_23657373_23657637	0.35	C10orf67	chromosome 10 open reading frame 67	23731	0.14
chr1_110044414_110044707	0.35	AMIGO1	adhesion molecule with Ig-like domain 1	7744	0.1
chr17_63389991_63390142	0.35	ENSG00000265189	.	26712	0.25
chr11_111249242_111249393	0.35	POU2AF1	POU class 2 associating factor 1	1100	0.4
chr19_1101918_1102169	0.34	GPX4	glutathione peroxidase 4	1893	0.19
chr5_10758811_10759088	0.34	CTD-2154B17.4		2228	0.31
chr9_137029668_137029819	0.34	ENSG00000221676	.	57	0.98
chr1_205249539_205249690	0.34	TMCC2	transmembrane and coiled-coil domain family 2	24285	0.14
chr10_116273295_116273446	0.34	ABLIM1	actin binding LIM protein 1	13224	0.26
chr3_47161644_47161795	0.33	ENSG00000251938	.	31621	0.14
chr1_226831568_226831736	0.33	ITPKB-IT1	ITPKB intronic transcript 1 (non-protein coding)	15719	0.2
chr12_123362223_123362374	0.33	VPS37B	vacuolar protein sorting 37 homolog B (S. cerevisiae)	12408	0.16
chr10_46993450_46993863	0.33	GPRIN2	G protein regulated inducer of neurite outgrowth 2	431	0.83
chr19_6801178_6801329	0.32	VAV1	vav 1 guanine nucleotide exchange factor	17124	0.13
chr9_126864333_126864484	0.32	RP11-85O21.5		69605	0.09
chr1_9776061_9776212	0.32	PIK3CD	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta	1991	0.31
chr3_112183882_112184126	0.32	BTLA	B and T lymphocyte associated	34201	0.19
chr8_133626087_133626238	0.32	LRRC6	leucine rich repeat containing 6	8772	0.26
chr10_43949825_43950368	0.32	ENSG00000252532	.	3417	0.21
chr16_78495483_78495634	0.31	RP11-264L1.4		44907	0.18
chr22_26960357_26960508	0.31	TPST2	tyrosylprotein sulfotransferase 2	902	0.52
chr10_32343092_32343538	0.31	KIF5B	kinesin family member 5B	2044	0.3
chr19_18061115_18061467	0.30	KCNN1	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1	811	0.53
chr14_91849387_91849607	0.30	CCDC88C	coiled-coil domain containing 88C	34193	0.17
chr2_69921039_69921201	0.30	ENSG00000238708	.	26629	0.17
chr13_28540402_28540553	0.30	CDX2	caudal type homeobox 2	4799	0.16
chr12_107350220_107350482	0.30	C12orf23	chromosome 12 open reading frame 23	212	0.89
chr2_204601227_204601398	0.29	ENSG00000211573	.	28209	0.17
chr18_13612912_13613063	0.29	LDLRAD4	low density lipoprotein receptor class A domain containing 4	369	0.78
chr10_134036875_134037037	0.29	DPYSL4	dihydropyrimidinase-like 4	30692	0.17
chr11_74661391_74661646	0.29	SPCS2	signal peptidase complex subunit 2 homolog (S. cerevisiae)	949	0.38
chr17_43140161_43140312	0.29	NMT1	N-myristoyltransferase 1	1189	0.31
chr9_130908064_130908215	0.28	LCN2	lipocalin 2	3211	0.11
chr11_72325339_72325508	0.28	ENSG00000272036	.	751	0.54
chr5_148725371_148725559	0.28	GRPEL2	GrpE-like 2, mitochondrial (E. coli)	400	0.77
chr16_2689747_2689898	0.28	PDPK2		2611	0.14
chr10_35661250_35661438	0.28	CCNY	cyclin Y	35542	0.16
chr19_37177667_37177944	0.28	ZNF567	zinc finger protein 567	725	0.63
chr17_75302751_75302902	0.28	SEPT9	septin 9	12771	0.22
chr2_230780997_230781148	0.27	TRIP12	thyroid hormone receptor interactor 12	5002	0.15
chr3_93780809_93781163	0.27	NSUN3	NOP2/Sun domain family, member 3	774	0.42
chr2_6555977_6556128	0.27	AC017076.5		417610	0.01
chr7_6220788_6221010	0.27	ENSG00000238534	.	5964	0.16
chr6_10412201_10412415	0.27	TFAP2A	transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)	299	0.88
chr6_16841177_16841328	0.27	RP1-151F17.1		79109	0.11
chr4_113331637_113331788	0.27	RP11-402J6.1		104829	0.06
chr15_22503682_22503919	0.27	ENSG00000221641	.	9480	0.14
chr18_47018108_47018337	0.27	RPL17	ribosomal protein L17	12	0.5
chr13_25245613_25245764	0.27	ATP12A	ATPase, H+/K+ transporting, nongastric, alpha polypeptide	8861	0.2
chr20_52225611_52225813	0.27	ZNF217	zinc finger protein 217	281	0.92
chr1_228266503_228266654	0.26	ARF1	ADP-ribosylation factor 1	3783	0.15
chr6_2999431_2999613	0.26	RP1-90J20.8		154	0.84
chr15_89164873_89165047	0.26	AEN	apoptosis enhancing nuclease	359	0.83
chr8_126941795_126942152	0.26	ENSG00000206695	.	28778	0.26
chr20_62384121_62384272	0.26	RP4-583P15.10		7297	0.09
chr10_82223013_82223255	0.26	TSPAN14	tetraspanin 14	4076	0.25
chr14_60974329_60974480	0.26	SIX6	SIX homeobox 6	1265	0.44
chr12_4324341_4324563	0.26	CCND2	cyclin D2	58486	0.11
chrX_38664687_38664838	0.26	MID1IP1-AS1	MID1IP1 antisense RNA 1	1626	0.37
chr7_42928264_42928421	0.26	C7orf25	chromosome 7 open reading frame 25	23167	0.2
chrX_55186672_55187118	0.26	FAM104B	family with sequence similarity 104, member B	640	0.71
chr19_2253973_2254124	0.25	JSRP1	junctional sarcoplasmic reticulum protein 1	1300	0.21
chr17_81039609_81039760	0.25	METRNL	meteorin, glial cell differentiation regulator-like	1609	0.44
chr7_2071644_2071795	0.25	MAD1L1	MAD1 mitotic arrest deficient-like 1 (yeast)	47929	0.17
chr17_80273270_80273608	0.25	CD7	CD7 molecule	1989	0.2
chr22_20147241_20147392	0.25	AC006547.14	uncharacterized protein LOC388849	8917	0.1
chr15_86127021_86127763	0.25	RP11-815J21.2		3983	0.21
chr3_25868001_25868329	0.25	OXSM	3-oxoacyl-ACP synthase, mitochondrial	35888	0.15
chr8_125650808_125651015	0.25	RP11-532M24.1		59039	0.11
chrX_147551933_147552084	0.25	AC002368.4		30127	0.19
chr16_87796018_87796169	0.25	KLHDC4	kelch domain containing 4	3412	0.22
chr1_24743655_24743881	0.25	NIPAL3	NIPA-like domain containing 3	1464	0.35
chr2_235392169_235392468	0.24	ARL4C	ADP-ribosylation factor-like 4C	12926	0.31
chr20_48688296_48688447	0.24	UBE2V1	ubiquitin-conjugating enzyme E2 variant 1	41305	0.13
chr1_232929880_232930031	0.24	MAP10	microtubule-associated protein 10	10688	0.25
chr15_45363161_45363312	0.24	RP11-109D20.2		3010	0.14
chr11_65400813_65401000	0.24	ENSG00000266041	.	2875	0.11
chr1_184535395_184535546	0.24	ENSG00000252790	.	111598	0.06
chr2_97629201_97629358	0.24	ENSG00000252845	.	6727	0.15
chr21_46529875_46530026	0.24	PRED58		4923	0.17
chr19_3984000_3984461	0.24	EEF2	eukaryotic translation elongation factor 2	1237	0.26
chr2_84767316_84767481	0.24	DNAH6	dynein, axonemal, heavy chain 6	22455	0.25
chr17_47654271_47654542	0.24	RP5-1029K10.4		918	0.33
chr20_47437720_47438218	0.23	PREX1	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1	6451	0.29
chr17_39968666_39968887	0.23	LEPREL4	leprecan-like 4	79	0.6
chr22_37317867_37318061	0.23	CSF2RB	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	212	0.91
chr19_16569538_16569703	0.23	EPS15L1	epidermal growth factor receptor pathway substrate 15-like 1	13134	0.12
chr2_131555405_131555556	0.23	AC133785.1		39087	0.1
chr9_80764703_80765036	0.23	ENSG00000222452	.	15512	0.27
chrX_153712773_153713180	0.22	UBL4A	ubiquitin-like 4A	1978	0.13
chr2_213966551_213966702	0.22	IKZF2	IKAROS family zinc finger 2 (Helios)	46727	0.18
chr17_26661694_26661916	0.22	IFT20	intraflagellar transport 20 homolog (Chlamydomonas)	656	0.35
chr12_54997312_54997463	0.22	PPP1R1A	protein phosphatase 1, regulatory (inhibitor) subunit 1A	14944	0.15
chr12_90345346_90345710	0.22	ENSG00000252823	.	197692	0.03
chr18_52274999_52275150	0.22	DYNAP	dynactin associated protein	16684	0.28
chr15_91240579_91240730	0.22	RP11-387D10.2		19626	0.13
chr17_19206898_19207138	0.22	EPN2-AS1	EPN2 antisense RNA 1	2556	0.18
chr22_40811745_40811947	0.21	RP5-1042K10.13		839	0.56
chr3_32469162_32469574	0.21	CMTM7	CKLF-like MARVEL transmembrane domain containing 7	35837	0.18
chr1_51191517_51191668	0.21	ENSG00000252825	.	24376	0.24
chr16_3074402_3074602	0.21	HCFC1R1	host cell factor C1 regulator 1 (XPO1 dependent)	215	0.63
chr1_54803697_54803848	0.21	RP5-997D24.3		52694	0.12
chr3_107646531_107646795	0.21	BBX	bobby sox homolog (Drosophila)	129225	0.06
chr17_66340406_66340557	0.21	ARSG	arylsulfatase G	52822	0.11
chr11_2913039_2913378	0.21	SLC22A18AS	solute carrier family 22 (organic cation transporter), member 18 antisense	2548	0.18
chr14_50406726_50407219	0.21	ENSG00000251929	.	38304	0.11
chr13_99717190_99717341	0.21	DOCK9	dedicator of cytokinesis 9	21395	0.17
chr14_22447304_22447455	0.21	ENSG00000238634	.	163508	0.03
chr14_92571937_92572120	0.20	ATXN3	ataxin 3	878	0.54
chr7_144055085_144055309	0.20	OR2A1-AS1	OR2A1 antisense RNA 1	1923	0.24
chr8_8198554_8198705	0.20	SGK223	Tyrosine-protein kinase SgK223	40628	0.17

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of PAX1_PAX9

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	0.8	GO:2000542	negative regulation of gastrulation(GO:2000542)
0.2	0.4	GO:0071481	cellular response to X-ray(GO:0071481)
0.1	0.5	GO:0032486	Rap protein signal transduction(GO:0032486)
0.1	0.3	GO:0032959	inositol trisphosphate biosynthetic process(GO:0032959)
0.1	0.3	GO:0070172	positive regulation of tooth mineralization(GO:0070172)
0.1	0.5	GO:0033169	histone H3-K9 demethylation(GO:0033169)
0.1	0.2	GO:0034626	fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.1	0.2	GO:0045048	protein insertion into ER membrane(GO:0045048) tail-anchored membrane protein insertion into ER membrane(GO:0071816)
0.0	0.1	GO:0044340	canonical Wnt signaling pathway involved in regulation of cell proliferation(GO:0044340)
0.0	0.1	GO:0046548	retinal rod cell development(GO:0046548)
0.0	0.5	GO:0045577	regulation of B cell differentiation(GO:0045577)
0.0	0.2	GO:0033194	response to hydroperoxide(GO:0033194)
0.0	0.4	GO:0015858	nucleoside transport(GO:0015858)
0.0	0.4	GO:0051568	histone H3-K4 methylation(GO:0051568)
0.0	0.1	GO:0044803	multi-organism membrane organization(GO:0044803)
0.0	0.1	GO:0007130	synaptonemal complex assembly(GO:0007130)
0.0	0.1	GO:0002860	natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002420) natural killer cell mediated immune response to tumor cell(GO:0002423) regulation of natural killer cell mediated immune response to tumor cell(GO:0002855) positive regulation of natural killer cell mediated immune response to tumor cell(GO:0002857) regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002858) positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002860)
0.0	0.1	GO:0006931	substrate-dependent cell migration, cell attachment to substrate(GO:0006931)
0.0	0.2	GO:0006491	N-glycan processing(GO:0006491)
0.0	0.1	GO:0006855	drug transmembrane transport(GO:0006855)
0.0	0.1	GO:0006477	protein sulfation(GO:0006477)
0.0	0.1	GO:0050847	progesterone receptor signaling pathway(GO:0050847)
0.0	0.1	GO:0007028	cytoplasm organization(GO:0007028)
0.0	0.2	GO:0034643	establishment of mitochondrion localization, microtubule-mediated(GO:0034643) mitochondrion transport along microtubule(GO:0047497)
0.0	0.1	GO:0006498	N-terminal protein lipidation(GO:0006498)
0.0	0.3	GO:0006750	glutathione biosynthetic process(GO:0006750)
0.0	0.1	GO:0060789	hair follicle placode formation(GO:0060789)
0.0	0.0	GO:0098801	regulation of glomerular filtration(GO:0003093) glomerular filtration(GO:0003094) renal filtration(GO:0097205) regulation of renal system process(GO:0098801)
0.0	0.1	GO:0006545	glycine biosynthetic process(GO:0006545)
0.0	0.1	GO:0071072	negative regulation of phospholipid biosynthetic process(GO:0071072)
0.0	0.1	GO:0006269	DNA replication, synthesis of RNA primer(GO:0006269)
0.0	0.1	GO:0050849	negative regulation of calcium-mediated signaling(GO:0050849)
0.0	0.0	GO:0007500	mesodermal cell fate determination(GO:0007500)
0.0	0.1	GO:0045047	protein targeting to ER(GO:0045047) establishment of protein localization to endoplasmic reticulum(GO:0072599)
0.0	0.0	GO:0045586	regulation of gamma-delta T cell differentiation(GO:0045586) positive regulation of gamma-delta T cell differentiation(GO:0045588)
0.0	0.0	GO:0030223	neutrophil differentiation(GO:0030223)
0.0	0.2	GO:0001782	B cell homeostasis(GO:0001782)
0.0	0.1	GO:0090073	positive regulation of protein homodimerization activity(GO:0090073)
0.0	0.1	GO:0006465	signal peptide processing(GO:0006465)
0.0	0.1	GO:0034088	maintenance of sister chromatid cohesion(GO:0034086) maintenance of mitotic sister chromatid cohesion(GO:0034088)
0.0	0.2	GO:0034453	microtubule anchoring(GO:0034453)
0.0	0.2	GO:0030889	negative regulation of B cell proliferation(GO:0030889)
0.0	0.1	GO:0035414	negative regulation of catenin import into nucleus(GO:0035414)
0.0	0.1	GO:0010507	negative regulation of autophagy(GO:0010507)
0.0	0.0	GO:0051790	short-chain fatty acid biosynthetic process(GO:0051790)
0.0	0.1	GO:0046655	folic acid metabolic process(GO:0046655)
0.0	0.1	GO:0018106	peptidyl-histidine phosphorylation(GO:0018106)
0.0	0.0	GO:0048478	replication fork protection(GO:0048478)
0.0	0.1	GO:0006689	ganglioside catabolic process(GO:0006689)
0.0	0.1	GO:0045066	regulatory T cell differentiation(GO:0045066)
0.0	0.3	GO:0051865	protein autoubiquitination(GO:0051865)
0.0	0.2	GO:0007220	Notch receptor processing(GO:0007220)
0.0	0.1	GO:0009214	cyclic nucleotide catabolic process(GO:0009214)
0.0	0.1	GO:0000089	mitotic metaphase(GO:0000089)
0.0	0.0	GO:0046607	positive regulation of centrosome cycle(GO:0046607)
0.0	0.2	GO:0071445	obsolete cellular response to protein stimulus(GO:0071445)
0.0	0.0	GO:0090292	nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0	0.0	GO:0010815	bradykinin catabolic process(GO:0010815)
0.0	0.2	GO:0043586	tongue development(GO:0043586)
0.0	0.0	GO:0061302	smooth muscle cell-matrix adhesion(GO:0061302)
0.0	0.2	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771)
0.0	0.0	GO:0006667	sphinganine metabolic process(GO:0006667)
0.0	0.1	GO:0007096	regulation of exit from mitosis(GO:0007096)
0.0	0.1	GO:0035608	protein deglutamylation(GO:0035608)
0.0	0.0	GO:0033173	calcineurin-NFAT signaling cascade(GO:0033173)
0.0	0.1	GO:0043268	positive regulation of potassium ion transport(GO:0043268)
0.0	0.2	GO:0034968	histone lysine methylation(GO:0034968)
0.0	0.1	GO:0002087	regulation of respiratory gaseous exchange by neurological system process(GO:0002087)
0.0	0.0	GO:0051503	adenine nucleotide transport(GO:0051503)
0.0	0.0	GO:0002098	tRNA wobble base modification(GO:0002097) tRNA wobble uridine modification(GO:0002098) tRNA thio-modification(GO:0034227)
0.0	0.1	GO:0046520	sphingoid biosynthetic process(GO:0046520)
0.0	0.0	GO:0045722	positive regulation of gluconeogenesis(GO:0045722)
0.0	0.0	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress(GO:0070059)
0.0	0.1	GO:0045059	positive thymic T cell selection(GO:0045059)
0.0	0.0	GO:0006772	thiamine metabolic process(GO:0006772)
0.0	0.1	GO:0055075	potassium ion homeostasis(GO:0055075)
0.0	0.1	GO:0036465	synaptic vesicle recycling(GO:0036465) synaptic vesicle endocytosis(GO:0048488) clathrin-mediated endocytosis(GO:0072583)
0.0	0.2	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0	0.1	GO:0071398	cellular response to fatty acid(GO:0071398)
0.0	0.0	GO:0033152	immunoglobulin V(D)J recombination(GO:0033152)
0.0	0.0	GO:0010916	regulation of very-low-density lipoprotein particle clearance(GO:0010915) negative regulation of very-low-density lipoprotein particle clearance(GO:0010916)
0.0	0.0	GO:0042149	cellular response to glucose starvation(GO:0042149)
0.0	0.0	GO:0045657	positive regulation of monocyte differentiation(GO:0045657)
0.0	0.2	GO:0030968	endoplasmic reticulum unfolded protein response(GO:0030968) cellular response to unfolded protein(GO:0034620)
0.0	0.0	GO:0042519	tyrosine phosphorylation of Stat4 protein(GO:0042504) regulation of tyrosine phosphorylation of Stat4 protein(GO:0042519) positive regulation of tyrosine phosphorylation of Stat4 protein(GO:0042520)
0.0	0.0	GO:0042732	D-xylose metabolic process(GO:0042732)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0072379	BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.0	0.6	GO:0042101	T cell receptor complex(GO:0042101)
0.0	0.3	GO:0071778	obsolete WINAC complex(GO:0071778)
0.0	0.4	GO:0048188	Set1C/COMPASS complex(GO:0048188)
0.0	0.1	GO:0005787	signal peptidase complex(GO:0005787)
0.0	0.6	GO:0032589	neuron projection membrane(GO:0032589)
0.0	0.1	GO:0005826	actomyosin contractile ring(GO:0005826)
0.0	0.1	GO:0005828	kinetochore microtubule(GO:0005828)
0.0	0.1	GO:0043625	delta DNA polymerase complex(GO:0043625)
0.0	0.1	GO:0005945	6-phosphofructokinase complex(GO:0005945)
0.0	0.1	GO:0043218	compact myelin(GO:0043218)
0.0	0.1	GO:0034451	centriolar satellite(GO:0034451)
0.0	0.2	GO:0016581	NuRD complex(GO:0016581) CHD-type complex(GO:0090545) nuclear transcriptional repressor complex(GO:0090568)
0.0	0.1	GO:0005827	polar microtubule(GO:0005827)
0.0	0.1	GO:0017059	palmitoyltransferase complex(GO:0002178) serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0	0.1	GO:0001740	Barr body(GO:0001740)
0.0	0.1	GO:0005658	alpha DNA polymerase:primase complex(GO:0005658)
0.0	0.1	GO:0005797	Golgi medial cisterna(GO:0005797)
0.0	0.1	GO:0005942	phosphatidylinositol 3-kinase complex(GO:0005942)
0.0	0.1	GO:0042582	primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.0	0.0	GO:0071986	Ragulator complex(GO:0071986)
0.0	0.1	GO:0042589	zymogen granule membrane(GO:0042589)
0.0	0.1	GO:0090533	cation-transporting ATPase complex(GO:0090533)
0.0	0.1	GO:0035253	ciliary rootlet(GO:0035253)
0.0	0.1	GO:0005678	obsolete chromatin assembly complex(GO:0005678)
0.0	0.0	GO:0035189	Rb-E2F complex(GO:0035189)
0.0	0.0	GO:0005589	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0	0.3	GO:0005776	autophagosome(GO:0005776)
0.0	0.1	GO:0043020	NADPH oxidase complex(GO:0043020)
0.0	0.0	GO:0098984	asymmetric synapse(GO:0032279) neuron to neuron synapse(GO:0098984)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0070087	chromo shadow domain binding(GO:0070087)
0.1	0.3	GO:0048018	receptor agonist activity(GO:0048018)
0.1	0.3	GO:0031685	adenosine receptor binding(GO:0031685)
0.1	0.4	GO:0042800	histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.1	0.5	GO:0050700	CARD domain binding(GO:0050700)
0.1	0.2	GO:0016286	small conductance calcium-activated potassium channel activity(GO:0016286)
0.0	0.1	GO:0008107	galactoside 2-alpha-L-fucosyltransferase activity(GO:0008107) alpha-(1,2)-fucosyltransferase activity(GO:0031127)
0.0	0.4	GO:1900750	glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.0	0.2	GO:0003828	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0	0.6	GO:0042813	Wnt-activated receptor activity(GO:0042813)
0.0	0.4	GO:0005337	nucleoside transmembrane transporter activity(GO:0005337)
0.0	0.2	GO:0003688	DNA replication origin binding(GO:0003688)
0.0	0.2	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.0	0.2	GO:0009922	fatty acid elongase activity(GO:0009922)
0.0	0.2	GO:0004969	histamine receptor activity(GO:0004969)
0.0	0.1	GO:0003896	DNA primase activity(GO:0003896)
0.0	0.1	GO:0034452	dynactin binding(GO:0034452)
0.0	0.1	GO:0000247	C-8 sterol isomerase activity(GO:0000247)
0.0	0.1	GO:0008518	reduced folate carrier activity(GO:0008518)
0.0	0.4	GO:0005545	1-phosphatidylinositol binding(GO:0005545)
0.0	0.1	GO:0016212	kynurenine-oxoglutarate transaminase activity(GO:0016212) kynurenine aminotransferase activity(GO:0036137)
0.0	0.1	GO:0016454	serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0	0.1	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.0	0.1	GO:0019911	structural constituent of myelin sheath(GO:0019911)
0.0	0.2	GO:0060590	ATPase regulator activity(GO:0060590)
0.0	0.1	GO:0070513	death domain binding(GO:0070513)
0.0	0.2	GO:0004602	glutathione peroxidase activity(GO:0004602)
0.0	0.1	GO:0003872	6-phosphofructokinase activity(GO:0003872)
0.0	0.1	GO:0008900	hydrogen:potassium-exchanging ATPase activity(GO:0008900)
0.0	0.1	GO:0043325	phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0	0.1	GO:0004873	asialoglycoprotein receptor activity(GO:0004873)
0.0	0.1	GO:0030276	clathrin binding(GO:0030276)
0.0	0.0	GO:0043533	inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.0	0.3	GO:0001540	beta-amyloid binding(GO:0001540)
0.0	0.2	GO:0008239	dipeptidyl-peptidase activity(GO:0008239)
0.0	0.0	GO:0015018	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
0.0	0.1	GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.0	0.0	GO:0050544	arachidonic acid binding(GO:0050544)
0.0	0.1	GO:0016004	phospholipase activator activity(GO:0016004)
0.0	0.1	GO:0015450	P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.0	0.0	GO:0043047	single-stranded telomeric DNA binding(GO:0043047) sequence-specific single stranded DNA binding(GO:0098847)
0.0	0.0	GO:0051880	G-quadruplex DNA binding(GO:0051880)
0.0	0.0	GO:0033829	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.0	0.0	GO:0000295	adenine nucleotide transmembrane transporter activity(GO:0000295) purine nucleotide transmembrane transporter activity(GO:0015216)
0.0	0.1	GO:0004030	aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.0	0.1	GO:0016290	palmitoyl-CoA hydrolase activity(GO:0016290)
0.0	0.1	GO:0008266	poly(U) RNA binding(GO:0008266)
0.0	0.0	GO:0008327	methyl-CpG binding(GO:0008327)
0.0	0.1	GO:0017166	vinculin binding(GO:0017166)
0.0	0.1	GO:0031996	thioesterase binding(GO:0031996)
0.0	0.0	GO:0050220	prostaglandin-E synthase activity(GO:0050220)
0.0	0.1	GO:0019992	diacylglycerol binding(GO:0019992)
0.0	0.1	GO:0004439	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity(GO:0004439)
0.0	0.0	GO:0004312	fatty acid synthase activity(GO:0004312)
0.0	0.0	GO:0004465	lipoprotein lipase activity(GO:0004465)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.6	PID WNT SIGNALING PATHWAY	Wnt signaling network
0.0	PID IFNG PATHWAY	IFN-gamma pathway
0.2	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.9	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
0.2	PID IL5 PATHWAY	IL5-mediated signaling events
0.3	ST ERK1 ERK2 MAPK PATHWAY	ERK1/ERK2 MAPK Pathway
0.4	SIG PIP3 SIGNALING IN B LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes
0.2	PID WNT CANONICAL PATHWAY	Canonical Wnt signaling pathway
0.1	PID BETA CATENIN DEG PATHWAY	Degradation of beta catenin
0.0	PID S1P S1P2 PATHWAY	S1P2 pathway
0.1	ST PHOSPHOINOSITIDE 3 KINASE PATHWAY	PI3K Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.4	REACTOME P2Y RECEPTORS	Genes involved in P2Y receptors
0.1	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0	REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE	Genes involved in Translocation of ZAP-70 to Immunological synapse
0.3	REACTOME REGULATION OF SIGNALING BY CBL	Genes involved in Regulation of signaling by CBL
0.2	REACTOME PURINE CATABOLISM	Genes involved in Purine catabolism
0.2	REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING	Genes involved in Downregulation of TGF-beta receptor signaling
0.6	REACTOME DOWNSTREAM TCR SIGNALING	Genes involved in Downstream TCR signaling
0.1	REACTOME REGULATED PROTEOLYSIS OF P75NTR	Genes involved in Regulated proteolysis of p75NTR
0.0	REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR	Genes involved in Prostacyclin signalling through prostacyclin receptor
0.4	REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES	Genes involved in Transport of vitamins, nucleosides, and related molecules
0.3	REACTOME GLUTATHIONE CONJUGATION	Genes involved in Glutathione conjugation
0.1	REACTOME P38MAPK EVENTS	Genes involved in p38MAPK events
0.0	REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION	Genes involved in Influenza Viral RNA Transcription and Replication
0.3	REACTOME IL RECEPTOR SHC SIGNALING	Genes involved in Interleukin receptor SHC signaling
0.1	REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1	Genes involved in SCF-beta-TrCP mediated degradation of Emi1
0.1	REACTOME POL SWITCHING	Genes involved in Polymerase switching
0.0	REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE	Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.1	REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GLP1	Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)
0.1	REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS	Genes involved in Synthesis of very long-chain fatty acyl-CoAs