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ENCODE: H3K4me1 ChIP-Seq of primary human cells
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Results for PAX1_PAX9

Z-value: 1.32

Motif logo

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Transcription factors associated with PAX1_PAX9

Gene Symbol Gene ID Gene Info
PAX1
ENSG00000125813.9 paired box 1
PAX9
ENSG00000198807.8 paired box 9

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr20_21684553_21684704PAX116690.5340970.891.3e-03Click!
chr20_21964047_21964198PAX12772610.014993-0.826.4e-03Click!
chr20_21683420_21683692PAX127410.4126950.791.1e-02Click!
chr20_21962216_21962367PAX12754300.015182-0.722.7e-02Click!
chr20_21963068_21963219PAX12762820.015094-0.703.6e-02Click!
chr14_37126012_37126279PAX96280.6700830.751.9e-02Click!
chr14_37125770_37125921PAX99280.5265750.742.4e-02Click!
chr14_37127166_37127317PAX94680.6225110.703.6e-02Click!
chr14_37126657_37126808PAX9410.9627220.684.5e-02Click!
chr14_37133644_37133795PAX919400.3255980.655.7e-02Click!

Activity of the PAX1_PAX9 motif across conditions

Conditions sorted by the z-value of the PAX1_PAX9 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr13_76210517_76210668 0.92 LMO7
 LIM domain 7
 133
 0.82
chr14_103852606_103852757 0.88 MARK3
 MAP/microtubule affinity-regulating kinase 3
 105
 0.96
chr2_70367797_70368219 0.84 C2orf42
 chromosome 2 open reading frame 42
 41119
 0.11
chr11_62405884_62406075 0.81 GANAB
 glucosidase, alpha; neutral AB
 8102
 0.06
chr3_152880548_152880699 0.81 RAP2B
 RAP2B, member of RAS oncogene family
 594
 0.63
chr6_5626865_5627048 0.80 RP1-256G22.2
68549
 0.13
chr18_77707966_77708117 0.78 PQLC1
 PQ loop repeat containing 1
 2776
 0.26
chr5_133747815_133748037 0.75 CDKN2AIPNL
 CDKN2A interacting protein N-terminal like
 337
 0.86
chr21_47012638_47012829 0.73 SLC19A1
 solute carrier family 19 (folate transporter), member 1
 48408
 0.13
chr7_64348404_64348555 0.72 RP11-797H7.5
1999
 0.34
chr6_130349340_130349950 0.71 L3MBTL3
 l(3)mbt-like 3 (Drosophila)
 7943
 0.29
chr7_149471850_149472001 0.71 ZNF467
 zinc finger protein 467
 1357
 0.47
chr15_70007265_70007861 0.71 ENSG00000238870
 .
 15598
 0.26
chr2_120967451_120967637 0.69 AC012363.4
6576
 0.18
chr17_28076156_28076317 0.67 RP11-82O19.1
11885
 0.16
chr14_21560524_21560677 0.64 ZNF219
 zinc finger protein 219
 1387
 0.24
chr8_82101889_82102084 0.63 PAG1
 phosphoprotein associated with glycosphingolipid microdomains 1
 77683
 0.1
chr5_36875594_36875785 0.62 NIPBL
 Nipped-B homolog (Drosophila)
 1172
 0.65
chr5_157030982_157031230 0.61 ENSG00000252068
 .
 24601
 0.13
chr4_4856521_4856672 0.60 MSX1
 msh homeobox 1
 4797
 0.31
chr16_85450287_85450438 0.59 ENSG00000264203
 .
 24736
 0.21
chr2_43397324_43397558 0.59 ZFP36L2
 ZFP36 ring finger protein-like 2
 56307
 0.13
chr20_35257246_35257397 0.59 SLA2
 Src-like-adaptor 2
 16963
 0.12
chr1_44890754_44890905 0.59 RNF220
 ring finger protein 220
 1117
 0.52
chr7_102072169_102072320 0.57 ORAI2
 ORAI calcium release-activated calcium modulator 2
 1309
 0.24
chr2_202899288_202899439 0.55 FZD7
 frizzled family receptor 7
 53
 0.97
chr2_33823948_33824099 0.54 FAM98A
 family with sequence similarity 98, member A
 321
 0.92
chr9_140173644_140173795 0.54 TOR4A
 torsin family 4, member A
 1518
 0.19
chr2_431196_431347 0.54 FAM150B
 family with sequence similarity 150, member B
 142420
 0.04
chr16_68026491_68026784 0.53 DPEP2
 dipeptidase 2
 1129
 0.26
chr13_48809535_48809778 0.53 ITM2B
 integral membrane protein 2B
 2317
 0.39
chr11_122714029_122714331 0.53 CRTAM
 cytotoxic and regulatory T cell molecule
 4972
 0.24
chr4_85888517_85888668 0.52 WDFY3
 WD repeat and FYVE domain containing 3
 1048
 0.66
chr19_49376384_49376535 0.52 PPP1R15A
 protein phosphatase 1, regulatory subunit 15A
 810
 0.4
chr16_4585585_4585736 0.52 CDIP1
 cell death-inducing p53 target 1
 2745
 0.18
chr5_177632572_177632811 0.51 HNRNPAB
 heterogeneous nuclear ribonucleoprotein A/B
 1119
 0.5
chr7_3083701_3083852 0.50 CARD11
 caspase recruitment domain family, member 11
 197
 0.96
chr9_20271155_20271306 0.50 ENSG00000221744
 .
 23772
 0.24
chr2_73495819_73495970 0.50 FBXO41
 F-box protein 41
 2149
 0.23
chr3_152553837_152554068 0.49 P2RY1
 purinergic receptor P2Y, G-protein coupled, 1
 1216
 0.65
chr9_73011935_73012121 0.49 KLF9
 Kruppel-like factor 9
 17512
 0.25
chr2_182451424_182451575 0.49 CERKL
 ceramide kinase-like
 70234
 0.11
chr19_10254387_10254800 0.48 EIF3G
 eukaryotic translation initiation factor 3, subunit G
 24015
 0.07
chr10_11269625_11270026 0.48 RP3-323N1.2
56486
 0.13
chr10_73078536_73078745 0.48 SLC29A3
 solute carrier family 29 (equilibrative nucleoside transporter), member 3
 375
 0.87
chr20_33542964_33543246 0.47 GSS
 glutathione synthetase
 515
 0.75
chr4_100742798_100742952 0.47 DAPP1
 dual adaptor of phosphotyrosine and 3-phosphoinositides
 4872
 0.27
chr9_140340558_140340709 0.47 ENTPD8
 ectonucleoside triphosphate diphosphohydrolase 8
 4732
 0.12
chr10_99393094_99393245 0.46 MORN4
 MORN repeat containing 4
 68
 0.96
chr7_919296_919447 0.45 GET4
 golgi to ER traffic protein 4 homolog (S. cerevisiae)
 1829
 0.27
chr11_43379396_43379615 0.45 TTC17
 tetratricopeptide repeat domain 17
 977
 0.41
chr16_67197044_67197250 0.44 HSF4
 heat shock transcription factor 4
 141
 0.87
chr2_219762742_219762992 0.44 WNT10A
 wingless-type MMTV integration site family, member 10A
 15984
 0.1
chr2_227552176_227552327 0.44 ENSG00000263363
 .
 28742
 0.23
chr6_35567353_35567706 0.44 ENSG00000212579
 .
 52066
 0.1
chr2_131484016_131484249 0.43 GPR148
 G protein-coupled receptor 148
 2511
 0.21
chr19_15528921_15529115 0.43 AKAP8L
 A kinase (PRKA) anchor protein 8-like
 781
 0.53
chr2_234350927_234351078 0.43 USP40
 ubiquitin specific peptidase 40
 47105
 0.11
chr14_24933172_24933323 0.43 SDR39U1
 short chain dehydrogenase/reductase family 39U, member 1
 21183
 0.1
chr1_118201201_118201563 0.42 ENSG00000212266
 .
 29982
 0.19
chr2_148257449_148257801 0.42 ENSG00000202074
 .
 4517
 0.24
chrX_80065881_80066270 0.42 BRWD3
 bromodomain and WD repeat domain containing 3
 888
 0.69
chr22_46038177_46038328 0.42 ENSG00000251985
 .
 17740
 0.18
chr12_58128443_58128594 0.42 AGAP2
 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
 2906
 0.09
chr5_140997623_140997787 0.41 AC008781.7
276
 0.75
chr18_47813563_47813872 0.41 CXXC1
 CXXC finger protein 1
 223
 0.92
chr2_68383804_68384020 0.41 WDR92
 WD repeat domain 92
 693
 0.52
chr1_228678315_228678466 0.41 RNF187
 ring finger protein 187
 3628
 0.1
chr21_34083416_34083567 0.41 SYNJ1
 synaptojanin 1
 15715
 0.15
chr13_41163913_41164388 0.40 AL133318.1
 Uncharacterized protein
 52827
 0.14
chr5_100237238_100237433 0.40 ST8SIA4
 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
 1583
 0.54
chr9_468550_468929 0.40 RP11-165F24.3
1063
 0.4
chr10_76345115_76345367 0.39 ENSG00000206756
 .
 34091
 0.2
chr3_151910786_151910994 0.39 MBNL1
 muscleblind-like splicing regulator 1
 74939
 0.11
chr2_64957617_64958033 0.39 ENSG00000253082
 .
 45413
 0.14
chr16_88638089_88638281 0.38 ZC3H18
 zinc finger CCCH-type containing 18
 1299
 0.39
chr1_228674208_228674396 0.38 RNF187
 ring finger protein 187
 460
 0.64
chr14_100068553_100068720 0.37 CCDC85C
 coiled-coil domain containing 85C
 1727
 0.34
chr9_2028066_2028217 0.37 SMARCA2
 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
 878
 0.68
chr7_36429553_36429704 0.37 KIAA0895
 KIAA0895
 67
 0.62
chr21_45559955_45560208 0.37 C21orf33
 chromosome 21 open reading frame 33
 4080
 0.18
chr16_88764300_88764451 0.37 RP5-1142A6.5
1466
 0.17
chr4_154709437_154709701 0.36 SFRP2
 secreted frizzled-related protein 2
 703
 0.71
chr2_234329659_234329810 0.36 DGKD
 diacylglycerol kinase, delta 130kDa
 32934
 0.14
chr8_8195680_8195853 0.36 SGK223
 Tyrosine-protein kinase SgK223
 43491
 0.16
chr1_9787735_9787886 0.36 PIK3CD
 phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
 9683
 0.17
chr14_68742179_68742813 0.35 ENSG00000243546
 .
 39240
 0.2
chr14_105863891_105864106 0.35 TEX22
 testis expressed 22
 922
 0.45
chr11_59538487_59538638 0.35 STX3
 syntaxin 3
 15637
 0.13
chr10_23657373_23657637 0.35 C10orf67
 chromosome 10 open reading frame 67
 23731
 0.14
chr1_110044414_110044707 0.35 AMIGO1
 adhesion molecule with Ig-like domain 1
 7744
 0.1
chr17_63389991_63390142 0.35 ENSG00000265189
 .
 26712
 0.25
chr11_111249242_111249393 0.35 POU2AF1
 POU class 2 associating factor 1
 1100
 0.4
chr19_1101918_1102169 0.34 GPX4
 glutathione peroxidase 4
 1893
 0.19
chr5_10758811_10759088 0.34 CTD-2154B17.4
2228
 0.31
chr9_137029668_137029819 0.34 ENSG00000221676
 .
 57
 0.98
chr1_205249539_205249690 0.34 TMCC2
 transmembrane and coiled-coil domain family 2
 24285
 0.14
chr10_116273295_116273446 0.34 ABLIM1
 actin binding LIM protein 1
 13224
 0.26
chr3_47161644_47161795 0.33 ENSG00000251938
 .
 31621
 0.14
chr1_226831568_226831736 0.33 ITPKB-IT1
 ITPKB intronic transcript 1 (non-protein coding)
 15719
 0.2
chr12_123362223_123362374 0.33 VPS37B
 vacuolar protein sorting 37 homolog B (S. cerevisiae)
 12408
 0.16
chr10_46993450_46993863 0.33 GPRIN2
 G protein regulated inducer of neurite outgrowth 2
 431
 0.83
chr19_6801178_6801329 0.32 VAV1
 vav 1 guanine nucleotide exchange factor
 17124
 0.13
chr9_126864333_126864484 0.32 RP11-85O21.5
69605
 0.09
chr1_9776061_9776212 0.32 PIK3CD
 phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
 1991
 0.31
chr3_112183882_112184126 0.32 BTLA
 B and T lymphocyte associated
 34201
 0.19
chr8_133626087_133626238 0.32 LRRC6
 leucine rich repeat containing 6
 8772
 0.26
chr10_43949825_43950368 0.32 ENSG00000252532
 .
 3417
 0.21
chr16_78495483_78495634 0.31 RP11-264L1.4
44907
 0.18
chr22_26960357_26960508 0.31 TPST2
 tyrosylprotein sulfotransferase 2
 902
 0.52
chr10_32343092_32343538 0.31 KIF5B
 kinesin family member 5B
 2044
 0.3
chr19_18061115_18061467 0.30 KCNN1
 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1
 811
 0.53
chr14_91849387_91849607 0.30 CCDC88C
 coiled-coil domain containing 88C
 34193
 0.17
chr2_69921039_69921201 0.30 ENSG00000238708
 .
 26629
 0.17
chr13_28540402_28540553 0.30 CDX2
 caudal type homeobox 2
 4799
 0.16
chr12_107350220_107350482 0.30 C12orf23
 chromosome 12 open reading frame 23
 212
 0.89
chr2_204601227_204601398 0.29 ENSG00000211573
 .
 28209
 0.17
chr18_13612912_13613063 0.29 LDLRAD4
 low density lipoprotein receptor class A domain containing 4
 369
 0.78
chr10_134036875_134037037 0.29 DPYSL4
 dihydropyrimidinase-like 4
 30692
 0.17
chr11_74661391_74661646 0.29 SPCS2
 signal peptidase complex subunit 2 homolog (S. cerevisiae)
 949
 0.38
chr17_43140161_43140312 0.29 NMT1
 N-myristoyltransferase 1
 1189
 0.31
chr9_130908064_130908215 0.28 LCN2
 lipocalin 2
 3211
 0.11
chr11_72325339_72325508 0.28 ENSG00000272036
 .
 751
 0.54
chr5_148725371_148725559 0.28 GRPEL2
 GrpE-like 2, mitochondrial (E. coli)
 400
 0.77
chr16_2689747_2689898 0.28 PDPK2
2611
 0.14
chr10_35661250_35661438 0.28 CCNY
 cyclin Y
 35542
 0.16
chr19_37177667_37177944 0.28 ZNF567
 zinc finger protein 567
 725
 0.63
chr17_75302751_75302902 0.28 SEPT9
 septin 9
 12771
 0.22
chr2_230780997_230781148 0.27 TRIP12
 thyroid hormone receptor interactor 12
 5002
 0.15
chr3_93780809_93781163 0.27 NSUN3
 NOP2/Sun domain family, member 3
 774
 0.42
chr2_6555977_6556128 0.27 AC017076.5
417610
 0.01
chr7_6220788_6221010 0.27 ENSG00000238534
 .
 5964
 0.16
chr6_10412201_10412415 0.27 TFAP2A
 transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
 299
 0.88
chr6_16841177_16841328 0.27 RP1-151F17.1
79109
 0.11
chr4_113331637_113331788 0.27 RP11-402J6.1
104829
 0.06
chr15_22503682_22503919 0.27 ENSG00000221641
 .
 9480
 0.14
chr18_47018108_47018337 0.27 RPL17
 ribosomal protein L17
 12
 0.5
chr13_25245613_25245764 0.27 ATP12A
 ATPase, H+/K+ transporting, nongastric, alpha polypeptide
 8861
 0.2
chr20_52225611_52225813 0.27 ZNF217
 zinc finger protein 217
 281
 0.92
chr1_228266503_228266654 0.26 ARF1
 ADP-ribosylation factor 1
 3783
 0.15
chr6_2999431_2999613 0.26 RP1-90J20.8
154
 0.84
chr15_89164873_89165047 0.26 AEN
 apoptosis enhancing nuclease
 359
 0.83
chr8_126941795_126942152 0.26 ENSG00000206695
 .
 28778
 0.26
chr20_62384121_62384272 0.26 RP4-583P15.10
7297
 0.09
chr10_82223013_82223255 0.26 TSPAN14
 tetraspanin 14
 4076
 0.25
chr14_60974329_60974480 0.26 SIX6
 SIX homeobox 6
 1265
 0.44
chr12_4324341_4324563 0.26 CCND2
 cyclin D2
 58486
 0.11
chrX_38664687_38664838 0.26 MID1IP1-AS1
 MID1IP1 antisense RNA 1
 1626
 0.37
chr7_42928264_42928421 0.26 C7orf25
 chromosome 7 open reading frame 25
 23167
 0.2
chrX_55186672_55187118 0.26 FAM104B
 family with sequence similarity 104, member B
 640
 0.71
chr19_2253973_2254124 0.25 JSRP1
 junctional sarcoplasmic reticulum protein 1
 1300
 0.21
chr17_81039609_81039760 0.25 METRNL
 meteorin, glial cell differentiation regulator-like
 1609
 0.44
chr7_2071644_2071795 0.25 MAD1L1
 MAD1 mitotic arrest deficient-like 1 (yeast)
 47929
 0.17
chr17_80273270_80273608 0.25 CD7
 CD7 molecule
 1989
 0.2
chr22_20147241_20147392 0.25 AC006547.14
 uncharacterized protein LOC388849
 8917
 0.1
chr15_86127021_86127763 0.25 RP11-815J21.2
3983
 0.21
chr3_25868001_25868329 0.25 OXSM
 3-oxoacyl-ACP synthase, mitochondrial
 35888
 0.15
chr8_125650808_125651015 0.25 RP11-532M24.1
59039
 0.11
chrX_147551933_147552084 0.25 AC002368.4
30127
 0.19
chr16_87796018_87796169 0.25 KLHDC4
 kelch domain containing 4
 3412
 0.22
chr1_24743655_24743881 0.25 NIPAL3
 NIPA-like domain containing 3
 1464
 0.35
chr2_235392169_235392468 0.24 ARL4C
 ADP-ribosylation factor-like 4C
 12926
 0.31
chr20_48688296_48688447 0.24 UBE2V1
 ubiquitin-conjugating enzyme E2 variant 1
 41305
 0.13
chr1_232929880_232930031 0.24 MAP10
 microtubule-associated protein 10
 10688
 0.25
chr15_45363161_45363312 0.24 RP11-109D20.2
3010
 0.14
chr11_65400813_65401000 0.24 ENSG00000266041
 .
 2875
 0.11
chr1_184535395_184535546 0.24 ENSG00000252790
 .
 111598
 0.06
chr2_97629201_97629358 0.24 ENSG00000252845
 .
 6727
 0.15
chr21_46529875_46530026 0.24 PRED58
4923
 0.17
chr19_3984000_3984461 0.24 EEF2
 eukaryotic translation elongation factor 2
 1237
 0.26
chr2_84767316_84767481 0.24 DNAH6
 dynein, axonemal, heavy chain 6
 22455
 0.25
chr17_47654271_47654542 0.24 RP5-1029K10.4
918
 0.33
chr20_47437720_47438218 0.23 PREX1
 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
 6451
 0.29
chr17_39968666_39968887 0.23 LEPREL4
 leprecan-like 4
 79
 0.6
chr22_37317867_37318061 0.23 CSF2RB
 colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
 212
 0.91
chr19_16569538_16569703 0.23 EPS15L1
 epidermal growth factor receptor pathway substrate 15-like 1
 13134
 0.12
chr2_131555405_131555556 0.23 AC133785.1
39087
 0.1
chr9_80764703_80765036 0.23 ENSG00000222452
 .
 15512
 0.27
chrX_153712773_153713180 0.22 UBL4A
 ubiquitin-like 4A
 1978
 0.13
chr2_213966551_213966702 0.22 IKZF2
 IKAROS family zinc finger 2 (Helios)
 46727
 0.18
chr17_26661694_26661916 0.22 IFT20
 intraflagellar transport 20 homolog (Chlamydomonas)
 656
 0.35
chr12_54997312_54997463 0.22 PPP1R1A
 protein phosphatase 1, regulatory (inhibitor) subunit 1A
 14944
 0.15
chr12_90345346_90345710 0.22 ENSG00000252823
 .
 197692
 0.03
chr18_52274999_52275150 0.22 DYNAP
 dynactin associated protein
 16684
 0.28
chr15_91240579_91240730 0.22 RP11-387D10.2
19626
 0.13
chr17_19206898_19207138 0.22 EPN2-AS1
 EPN2 antisense RNA 1
 2556
 0.18
chr22_40811745_40811947 0.21 RP5-1042K10.13
839
 0.56
chr3_32469162_32469574 0.21 CMTM7
 CKLF-like MARVEL transmembrane domain containing 7
 35837
 0.18
chr1_51191517_51191668 0.21 ENSG00000252825
 .
 24376
 0.24
chr16_3074402_3074602 0.21 HCFC1R1
 host cell factor C1 regulator 1 (XPO1 dependent)
 215
 0.63
chr1_54803697_54803848 0.21 RP5-997D24.3
52694
 0.12
chr3_107646531_107646795 0.21 BBX
 bobby sox homolog (Drosophila)
 129225
 0.06
chr17_66340406_66340557 0.21 ARSG
 arylsulfatase G
 52822
 0.11
chr11_2913039_2913378 0.21 SLC22A18AS
 solute carrier family 22 (organic cation transporter), member 18 antisense
 2548
 0.18
chr14_50406726_50407219 0.21 ENSG00000251929
 .
 38304
 0.11
chr13_99717190_99717341 0.21 DOCK9
 dedicator of cytokinesis 9
 21395
 0.17
chr14_22447304_22447455 0.21 ENSG00000238634
 .
 163508
 0.03
chr14_92571937_92572120 0.20 ATXN3
 ataxin 3
 878
 0.54
chr7_144055085_144055309 0.20 OR2A1-AS1
 OR2A1 antisense RNA 1
 1923
 0.24
chr8_8198554_8198705 0.20 SGK223
 Tyrosine-protein kinase SgK223
 40628
 0.17

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of PAX1_PAX9

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:2000542 negative regulation of gastrulation(GO:2000542)
0.2 0.4 GO:0071481 cellular response to X-ray(GO:0071481)
0.1 0.5 GO:0032486 Rap protein signal transduction(GO:0032486)
0.1 0.3 GO:0032959 inositol trisphosphate biosynthetic process(GO:0032959)
0.1 0.3 GO:0070172 positive regulation of tooth mineralization(GO:0070172)
0.1 0.5 GO:0033169 histone H3-K9 demethylation(GO:0033169)
0.1 0.2 GO:0034626 fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.1 0.2 GO:0045048 protein insertion into ER membrane(GO:0045048) tail-anchored membrane protein insertion into ER membrane(GO:0071816)
0.0 0.1 GO:0044340 canonical Wnt signaling pathway involved in regulation of cell proliferation(GO:0044340)
0.0 0.1 GO:0046548 retinal rod cell development(GO:0046548)
0.0 0.5 GO:0045577 regulation of B cell differentiation(GO:0045577)
0.0 0.2 GO:0033194 response to hydroperoxide(GO:0033194)
0.0 0.4 GO:0015858 nucleoside transport(GO:0015858)
0.0 0.4 GO:0051568 histone H3-K4 methylation(GO:0051568)
0.0 0.1 GO:0044803 multi-organism membrane organization(GO:0044803)
0.0 0.1 GO:0007130 synaptonemal complex assembly(GO:0007130)
0.0 0.1 GO:0002860 natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002420) natural killer cell mediated immune response to tumor cell(GO:0002423) regulation of natural killer cell mediated immune response to tumor cell(GO:0002855) positive regulation of natural killer cell mediated immune response to tumor cell(GO:0002857) regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002858) positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002860)
0.0 0.1 GO:0006931 substrate-dependent cell migration, cell attachment to substrate(GO:0006931)
0.0 0.2 GO:0006491 N-glycan processing(GO:0006491)
0.0 0.1 GO:0006855 drug transmembrane transport(GO:0006855)
0.0 0.1 GO:0006477 protein sulfation(GO:0006477)
0.0 0.1 GO:0050847 progesterone receptor signaling pathway(GO:0050847)
0.0 0.1 GO:0007028 cytoplasm organization(GO:0007028)
0.0 0.2 GO:0034643 establishment of mitochondrion localization, microtubule-mediated(GO:0034643) mitochondrion transport along microtubule(GO:0047497)
0.0 0.1 GO:0006498 N-terminal protein lipidation(GO:0006498)
0.0 0.3 GO:0006750 glutathione biosynthetic process(GO:0006750)
0.0 0.1 GO:0060789 hair follicle placode formation(GO:0060789)
0.0 0.0 GO:0098801 regulation of glomerular filtration(GO:0003093) glomerular filtration(GO:0003094) renal filtration(GO:0097205) regulation of renal system process(GO:0098801)
0.0 0.1 GO:0006545 glycine biosynthetic process(GO:0006545)
0.0 0.1 GO:0071072 negative regulation of phospholipid biosynthetic process(GO:0071072)
0.0 0.1 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
0.0 0.1 GO:0050849 negative regulation of calcium-mediated signaling(GO:0050849)
0.0 0.0 GO:0007500 mesodermal cell fate determination(GO:0007500)
0.0 0.1 GO:0045047 protein targeting to ER(GO:0045047) establishment of protein localization to endoplasmic reticulum(GO:0072599)
0.0 0.0 GO:0045586 regulation of gamma-delta T cell differentiation(GO:0045586) positive regulation of gamma-delta T cell differentiation(GO:0045588)
0.0 0.0 GO:0030223 neutrophil differentiation(GO:0030223)
0.0 0.2 GO:0001782 B cell homeostasis(GO:0001782)
0.0 0.1 GO:0090073 positive regulation of protein homodimerization activity(GO:0090073)
0.0 0.1 GO:0006465 signal peptide processing(GO:0006465)
0.0 0.1 GO:0034088 maintenance of sister chromatid cohesion(GO:0034086) maintenance of mitotic sister chromatid cohesion(GO:0034088)
0.0 0.2 GO:0034453 microtubule anchoring(GO:0034453)
0.0 0.2 GO:0030889 negative regulation of B cell proliferation(GO:0030889)
0.0 0.1 GO:0035414 negative regulation of catenin import into nucleus(GO:0035414)
0.0 0.1 GO:0010507 negative regulation of autophagy(GO:0010507)
0.0 0.0 GO:0051790 short-chain fatty acid biosynthetic process(GO:0051790)
0.0 0.1 GO:0046655 folic acid metabolic process(GO:0046655)
0.0 0.1 GO:0018106 peptidyl-histidine phosphorylation(GO:0018106)
0.0 0.0 GO:0048478 replication fork protection(GO:0048478)
0.0 0.1 GO:0006689 ganglioside catabolic process(GO:0006689)
0.0 0.1 GO:0045066 regulatory T cell differentiation(GO:0045066)
0.0 0.3 GO:0051865 protein autoubiquitination(GO:0051865)
0.0 0.2 GO:0007220 Notch receptor processing(GO:0007220)
0.0 0.1 GO:0009214 cyclic nucleotide catabolic process(GO:0009214)
0.0 0.1 GO:0000089 mitotic metaphase(GO:0000089)
0.0 0.0 GO:0046607 positive regulation of centrosome cycle(GO:0046607)
0.0 0.2 GO:0071445 obsolete cellular response to protein stimulus(GO:0071445)
0.0 0.0 GO:0090292 nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0 0.0 GO:0010815 bradykinin catabolic process(GO:0010815)
0.0 0.2 GO:0043586 tongue development(GO:0043586)
0.0 0.0 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.0 0.2 GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771)
0.0 0.0 GO:0006667 sphinganine metabolic process(GO:0006667)
0.0 0.1 GO:0007096 regulation of exit from mitosis(GO:0007096)
0.0 0.1 GO:0035608 protein deglutamylation(GO:0035608)
0.0 0.0 GO:0033173 calcineurin-NFAT signaling cascade(GO:0033173)
0.0 0.1 GO:0043268 positive regulation of potassium ion transport(GO:0043268)
0.0 0.2 GO:0034968 histone lysine methylation(GO:0034968)
0.0 0.1 GO:0002087 regulation of respiratory gaseous exchange by neurological system process(GO:0002087)
0.0 0.0 GO:0051503 adenine nucleotide transport(GO:0051503)
0.0 0.0 GO:0002098 tRNA wobble base modification(GO:0002097) tRNA wobble uridine modification(GO:0002098) tRNA thio-modification(GO:0034227)
0.0 0.1 GO:0046520 sphingoid biosynthetic process(GO:0046520)
0.0 0.0 GO:0045722 positive regulation of gluconeogenesis(GO:0045722)
0.0 0.0 GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress(GO:0070059)
0.0 0.1 GO:0045059 positive thymic T cell selection(GO:0045059)
0.0 0.0 GO:0006772 thiamine metabolic process(GO:0006772)
0.0 0.1 GO:0055075 potassium ion homeostasis(GO:0055075)
0.0 0.1 GO:0036465 synaptic vesicle recycling(GO:0036465) synaptic vesicle endocytosis(GO:0048488) clathrin-mediated endocytosis(GO:0072583)
0.0 0.2 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 0.1 GO:0071398 cellular response to fatty acid(GO:0071398)
0.0 0.0 GO:0033152 immunoglobulin V(D)J recombination(GO:0033152)
0.0 0.0 GO:0010916 regulation of very-low-density lipoprotein particle clearance(GO:0010915) negative regulation of very-low-density lipoprotein particle clearance(GO:0010916)
0.0 0.0 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.0 0.0 GO:0045657 positive regulation of monocyte differentiation(GO:0045657)
0.0 0.2 GO:0030968 endoplasmic reticulum unfolded protein response(GO:0030968) cellular response to unfolded protein(GO:0034620)
0.0 0.0 GO:0042519 tyrosine phosphorylation of Stat4 protein(GO:0042504) regulation of tyrosine phosphorylation of Stat4 protein(GO:0042519) positive regulation of tyrosine phosphorylation of Stat4 protein(GO:0042520)
0.0 0.0 GO:0042732 D-xylose metabolic process(GO:0042732)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0072379 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.0 0.6 GO:0042101 T cell receptor complex(GO:0042101)
0.0 0.3 GO:0071778 obsolete WINAC complex(GO:0071778)
0.0 0.4 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.0 0.1 GO:0005787 signal peptidase complex(GO:0005787)
0.0 0.6 GO:0032589 neuron projection membrane(GO:0032589)
0.0 0.1 GO:0005826 actomyosin contractile ring(GO:0005826)
0.0 0.1 GO:0005828 kinetochore microtubule(GO:0005828)
0.0 0.1 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.0 0.1 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.0 0.1 GO:0043218 compact myelin(GO:0043218)
0.0 0.1 GO:0034451 centriolar satellite(GO:0034451)
0.0 0.2 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545) nuclear transcriptional repressor complex(GO:0090568)
0.0 0.1 GO:0005827 polar microtubule(GO:0005827)
0.0 0.1 GO:0017059 palmitoyltransferase complex(GO:0002178) serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0 0.1 GO:0001740 Barr body(GO:0001740)
0.0 0.1 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.0 0.1 GO:0005797 Golgi medial cisterna(GO:0005797)
0.0 0.1 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.1 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.0 0.0 GO:0071986 Ragulator complex(GO:0071986)
0.0 0.1 GO:0042589 zymogen granule membrane(GO:0042589)
0.0 0.1 GO:0090533 cation-transporting ATPase complex(GO:0090533)
0.0 0.1 GO:0035253 ciliary rootlet(GO:0035253)
0.0 0.1 GO:0005678 obsolete chromatin assembly complex(GO:0005678)
0.0 0.0 GO:0035189 Rb-E2F complex(GO:0035189)
0.0 0.0 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0 0.3 GO:0005776 autophagosome(GO:0005776)
0.0 0.1 GO:0043020 NADPH oxidase complex(GO:0043020)
0.0 0.0 GO:0098984 asymmetric synapse(GO:0032279) neuron to neuron synapse(GO:0098984)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0070087 chromo shadow domain binding(GO:0070087)
0.1 0.3 GO:0048018 receptor agonist activity(GO:0048018)
0.1 0.3 GO:0031685 adenosine receptor binding(GO:0031685)
0.1 0.4 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.1 0.5 GO:0050700 CARD domain binding(GO:0050700)
0.1 0.2 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.0 0.1 GO:0008107 galactoside 2-alpha-L-fucosyltransferase activity(GO:0008107) alpha-(1,2)-fucosyltransferase activity(GO:0031127)
0.0 0.4 GO:1900750 glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.0 0.2 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0 0.6 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.4 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.0 0.2 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 0.2 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.0 0.2 GO:0009922 fatty acid elongase activity(GO:0009922)
0.0 0.2 GO:0004969 histamine receptor activity(GO:0004969)
0.0 0.1 GO:0003896 DNA primase activity(GO:0003896)
0.0 0.1 GO:0034452 dynactin binding(GO:0034452)
0.0 0.1 GO:0000247 C-8 sterol isomerase activity(GO:0000247)
0.0 0.1 GO:0008518 reduced folate carrier activity(GO:0008518)
0.0 0.4 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.0 0.1 GO:0016212 kynurenine-oxoglutarate transaminase activity(GO:0016212) kynurenine aminotransferase activity(GO:0036137)
0.0 0.1 GO:0016454 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0 0.1 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.0 0.1 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.2 GO:0060590 ATPase regulator activity(GO:0060590)
0.0 0.1 GO:0070513 death domain binding(GO:0070513)
0.0 0.2 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.0 0.1 GO:0003872 6-phosphofructokinase activity(GO:0003872)
0.0 0.1 GO:0008900 hydrogen:potassium-exchanging ATPase activity(GO:0008900)
0.0 0.1 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0 0.1 GO:0004873 asialoglycoprotein receptor activity(GO:0004873)
0.0 0.1 GO:0030276 clathrin binding(GO:0030276)
0.0 0.0 GO:0043533 inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.0 0.3 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 0.2 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.0 0.0 GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
0.0 0.1 GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.0 0.0 GO:0050544 arachidonic acid binding(GO:0050544)
0.0 0.1 GO:0016004 phospholipase activator activity(GO:0016004)
0.0 0.1 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.0 0.0 GO:0043047 single-stranded telomeric DNA binding(GO:0043047) sequence-specific single stranded DNA binding(GO:0098847)
0.0 0.0 GO:0051880 G-quadruplex DNA binding(GO:0051880)
0.0 0.0 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.0 0.0 GO:0000295 adenine nucleotide transmembrane transporter activity(GO:0000295) purine nucleotide transmembrane transporter activity(GO:0015216)
0.0 0.1 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.0 0.1 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.0 0.1 GO:0008266 poly(U) RNA binding(GO:0008266)
0.0 0.0 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 0.1 GO:0017166 vinculin binding(GO:0017166)
0.0 0.1 GO:0031996 thioesterase binding(GO:0031996)
0.0 0.0 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
0.0 0.1 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 0.1 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity(GO:0004439)
0.0 0.0 GO:0004312 fatty acid synthase activity(GO:0004312)
0.0 0.0 GO:0004465 lipoprotein lipase activity(GO:0004465)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 0.0 PID IFNG PATHWAY IFN-gamma pathway
0.0 0.2 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 0.9 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.0 0.2 PID IL5 PATHWAY IL5-mediated signaling events
0.0 0.3 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.0 0.4 SIG PIP3 SIGNALING IN B LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.0 0.2 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway
0.0 0.1 PID BETA CATENIN DEG PATHWAY Degradation of beta catenin
0.0 0.0 PID S1P S1P2 PATHWAY S1P2 pathway
0.0 0.1 ST PHOSPHOINOSITIDE 3 KINASE PATHWAY PI3K Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.0 0.1 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0 0.0 REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.0 0.3 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.0 0.2 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.0 0.2 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 0.6 REACTOME DOWNSTREAM TCR SIGNALING Genes involved in Downstream TCR signaling
0.0 0.1 REACTOME REGULATED PROTEOLYSIS OF P75NTR Genes involved in Regulated proteolysis of p75NTR
0.0 0.0 REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR Genes involved in Prostacyclin signalling through prostacyclin receptor
0.0 0.4 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 0.3 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 0.1 REACTOME P38MAPK EVENTS Genes involved in p38MAPK events
0.0 0.0 REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION Genes involved in Influenza Viral RNA Transcription and Replication
0.0 0.3 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 0.1 REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1 Genes involved in SCF-beta-TrCP mediated degradation of Emi1
0.0 0.1 REACTOME POL SWITCHING Genes involved in Polymerase switching
0.0 0.0 REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0 0.1 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GLP1 Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)
0.0 0.1 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs