Project

ENCODE: H3K4me1 ChIP-Seq of primary human cells

Navigation

Downloads

CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for PAX3

Z-value: 1.17

Motif logo

Transcription factors associated with PAX3

Gene Symbol	Gene ID	Gene Info
PAX3 Ensembl NCBI GeneCards UniProt	ENSG00000135903.14	PAX3

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
PAX3	chr2_223164777_223164928	1137	0.443002	0.56	1.1e-01	Click!
PAX3	chr2_223163781_223163932	141	0.923324	-0.52	1.6e-01	Click!
PAX3	chr2_223164524_223164675	884	0.527523	0.46	2.1e-01	Click!
PAX3	chr2_223164169_223164320	529	0.701476	-0.34	3.7e-01	Click!
PAX3	chr2_223163217_223163499	107	0.861826	-0.06	8.7e-01	Click!

Activity of the PAX3 motif across conditions

Conditions sorted by the z-value of the PAX3 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr11_44630927_44631130	0.40	RP11-58K22.4		1377	0.42
chr12_56210624_56211230	0.36	SARNP	SAP domain containing ribonucleoprotein	566	0.44
chr10_111972940_111973241	0.34	MXI1	MAX interactor 1, dimerization protein	3101	0.27
chr1_100504806_100504996	0.33	HIAT1	hippocampus abundant transcript 1	1248	0.37
chr5_100188313_100188787	0.31	ENSG00000221263	.	36281	0.2
chr3_46005698_46005849	0.31	FYCO1	FYVE and coiled-coil domain containing 1	5620	0.18
chr2_113943413_113943847	0.29	PSD4	pleckstrin and Sec7 domain containing 4	10227	0.14
chr8_103389332_103389537	0.29	ENSG00000238533	.	11429	0.19
chr9_95817754_95818259	0.28	SUSD3	sushi domain containing 3	2983	0.24
chr9_98513414_98513617	0.27	DKFZP434H0512	Protein LOC100506667; Putative uncharacterized protein DKFZp434H0512	21090	0.24
chr14_99399270_99399624	0.27	C14orf177	chromosome 14 open reading frame 177	221490	0.02
chr11_587585_588264	0.27	PHRF1	PHD and ring finger domains 1	11403	0.07
chr7_37391286_37391569	0.26	ENSG00000222869	.	680	0.66
chr16_84647052_84647203	0.26	COTL1	coactosin-like 1 (Dictyostelium)	4538	0.2
chr11_128588934_128589085	0.26	SENCR	smooth muscle and endothelial cell enriched migration/differentiation-associated long non-coding RNA	23091	0.17
chr1_181006045_181006268	0.26	MR1	major histocompatibility complex, class I-related	3017	0.23
chr3_71535527_71535739	0.26	ENSG00000221264	.	55607	0.13
chr14_52407231_52407382	0.26	RP11-463J10.2	Uncharacterized protein	22017	0.13
chr15_45027905_45028453	0.25	TRIM69	tripartite motif containing 69	381	0.83
chr19_57182581_57182785	0.25	ZNF835	zinc finger protein 835	445	0.78
chr6_24930509_24931296	0.24	FAM65B	family with sequence similarity 65, member B	5286	0.26
chr16_66624775_66624926	0.24	RP11-403P17.2		10231	0.1
chr8_82006436_82006760	0.24	PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	17705	0.27
chr13_111526304_111526455	0.24	LINC00346	long intergenic non-protein coding RNA 346	4217	0.23
chr22_40326443_40326594	0.23	GRAP2	GRB2-related adaptor protein 2	3877	0.21
chr2_137038474_137038625	0.23	ENSG00000251976	.	109353	0.07
chr20_24962019_24962324	0.23	ENSG00000207355	.	7364	0.19
chr14_93115762_93116231	0.23	RIN3	Ras and Rab interactor 3	2850	0.36
chr17_38771222_38771726	0.23	SMARCE1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1	17068	0.14
chr7_157182070_157182377	0.22	DNAJB6	DnaJ (Hsp40) homolog, subfamily B, member 6	49708	0.15
chr19_10870035_10870582	0.22	ENSG00000265879	.	20622	0.11
chr13_24824909_24825522	0.22	SPATA13	spermatogenesis associated 13	617	0.7
chr2_233184314_233184699	0.22	DIS3L2	DIS3 mitotic control homolog (S. cerevisiae)-like 2	14147	0.18
chr2_127419346_127420030	0.22	GYPC	glycophorin C (Gerbich blood group)	5928	0.29
chrX_135742690_135742856	0.22	CD40LG	CD40 ligand	12387	0.17
chr2_158286835_158286986	0.22	CYTIP	cytohesin 1 interacting protein	9016	0.22
chr5_1503386_1503697	0.22	LPCAT1	lysophosphatidylcholine acyltransferase 1	20551	0.2
chrX_135842036_135842388	0.22	ARHGEF6	Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6	7290	0.19
chr11_85411371_85411865	0.22	CCDC89	coiled-coil domain containing 89	14298	0.15
chr19_4115268_4115780	0.22	MAP2K2	mitogen-activated protein kinase kinase 2	8590	0.13
chr7_5461177_5461902	0.22	TNRC18	trinucleotide repeat containing 18	1638	0.24
chr2_235392806_235393340	0.22	ARL4C	ADP-ribosylation factor-like 4C	12171	0.32
chr17_8771075_8771247	0.21	PIK3R6	phosphoinositide-3-kinase, regulatory subunit 6	167	0.96
chr2_136872566_136873100	0.21	CXCR4	chemokine (C-X-C motif) receptor 4	980	0.68
chr20_1602531_1602783	0.21	RP4-576H24.4	Uncharacterized protein	2002	0.21
chr12_72043386_72043537	0.21	ENSG00000212461	.	10326	0.16
chr2_198157391_198157702	0.21	ANKRD44-IT1	ANKRD44 intronic transcript 1 (non-protein coding)	9697	0.17
chrX_78427887_78428156	0.21	GPR174	G protein-coupled receptor 174	1552	0.57
chr12_116651690_116651896	0.21	RP11-115H15.2		32693	0.16
chr2_145459727_145459992	0.21	ZEB2	zinc finger E-box binding homeobox 2	181238	0.03
chr14_23939099_23939325	0.21	NGDN	neuroguidin, EIF4E binding protein	47	0.96
chr2_54806316_54807000	0.20	SPTBN1	spectrin, beta, non-erythrocytic 1	21127	0.18
chr19_55009447_55009893	0.20	LAIR2	leukocyte-associated immunoglobulin-like receptor 2	570	0.6
chr4_15022705_15022879	0.20	CPEB2	cytoplasmic polyadenylation element binding protein 2	17232	0.27
chr10_111775510_111775661	0.20	ADD3	adducin 3 (gamma)	7863	0.21
chr13_48718601_48718752	0.20	MED4	mediator complex subunit 4	49409	0.14
chr6_39079511_39079662	0.20	SAYSD1	SAYSVFN motif domain containing 1	2238	0.39
chr7_104696089_104696325	0.20	KMT2E	lysine (K)-specific methyltransferase 2E	41299	0.12
chr9_132700843_132701237	0.20	RP11-409K20.6		5225	0.21
chr16_84792149_84792512	0.20	USP10	ubiquitin specific peptidase 10	9541	0.21
chr19_33666219_33666370	0.20	ENSG00000264355	.	1684	0.23
chr18_29628950_29629327	0.20	ENSG00000265063	.	11814	0.14
chr2_158325492_158325945	0.20	CYTIP	cytohesin 1 interacting protein	19623	0.21
chr10_32629803_32629954	0.20	RP11-135A24.4		5549	0.14
chr1_100887321_100887588	0.20	ENSG00000216067	.	43123	0.14
chr8_81477973_81478412	0.20	ENSG00000223327	.	19816	0.2
chr21_36414924_36415236	0.20	RUNX1	runt-related transcription factor 1	6382	0.34
chr7_50448999_50449150	0.20	ENSG00000200815	.	54004	0.14
chr10_11186185_11186414	0.19	CELF2	CUGBP, Elav-like family member 2	20694	0.19
chr17_29632882_29633122	0.19	EVI2B	ecotropic viral integration site 2B	8100	0.13
chr12_6535038_6535392	0.19	CD27	CD27 molecule	18818	0.09
chr6_143177440_143177974	0.19	HIVEP2	human immunodeficiency virus type I enhancer binding protein 2	19523	0.26
chrX_153947159_153947493	0.19	GAB3	GRB2-associated binding protein 3	32006	0.1
chr12_15130915_15131069	0.19	PDE6H	phosphodiesterase 6H, cGMP-specific, cone, gamma	5036	0.2
chr4_166249313_166249610	0.19	MSMO1	methylsterol monooxygenase 1	382	0.88
chr11_122597336_122597788	0.19	ENSG00000239079	.	543	0.83
chr10_5489002_5489404	0.19	NET1	neuroepithelial cell transforming 1	629	0.71
chr12_102437834_102438009	0.19	CCDC53	coiled-coil domain containing 53	1976	0.32
chr5_53840666_53840817	0.19	SNX18	sorting nexin 18	27148	0.24
chr1_167620769_167621002	0.19	RP3-455J7.4		20974	0.18
chr12_56420621_56420772	0.19	IKZF4	IKAROS family zinc finger 4 (Eos)	5596	0.09
chr1_154127490_154127791	0.19	NUP210L	nucleoporin 210kDa-like	48	0.95
chr11_96069523_96069674	0.19	ENSG00000266192	.	5004	0.22
chr6_96034444_96034595	0.19	MANEA	mannosidase, endo-alpha	9100	0.25
chr6_109340701_109340852	0.19	SESN1	sestrin 1	10018	0.19
chr16_89850957_89851182	0.19	FANCA	Fanconi anemia, complementation group A	31974	0.1
chr17_4081322_4081473	0.19	ENSG00000251812	.	8224	0.12
chr21_44203039_44203232	0.19	AP001627.1		41267	0.15
chr2_198044307_198044458	0.19	ANKRD44	ankyrin repeat domain 44	7451	0.23
chr14_73002896_73003047	0.19	RGS6	regulator of G-protein signaling 6	76594	0.12
chr5_14594455_14594804	0.19	FAM105A	family with sequence similarity 105, member A	12745	0.24
chr11_6742741_6742892	0.19	GVINP1	GTPase, very large interferon inducible pseudogene 1	295	0.86
chr9_123551480_123551631	0.18	FBXW2	F-box and WD repeat domain containing 2	4100	0.22
chr6_167366901_167367052	0.18	RP11-514O12.4		2636	0.2
chr1_206751930_206752246	0.18	RASSF5	Ras association (RalGDS/AF-6) domain family member 5	21595	0.14
chr20_31560742_31561149	0.18	EFCAB8	EF-hand calcium binding domain 8	13294	0.15
chr3_187971650_187971801	0.18	LPP	LIM domain containing preferred translocation partner in lipoma	14073	0.27
chr14_68751578_68751902	0.18	ENSG00000243546	.	48484	0.17
chr6_108145921_108146601	0.18	SCML4	sex comb on midleg-like 4 (Drosophila)	740	0.76
chr3_4536511_4536662	0.18	ITPR1	inositol 1,4,5-trisphosphate receptor, type 1	1352	0.39
chr6_149397702_149397853	0.18	RP11-162J8.3		44068	0.17
chr13_74803959_74804110	0.18	ENSG00000206617	.	59317	0.15
chr11_44992839_44992990	0.18	TP53I11	tumor protein p53 inducible protein 11	20306	0.24
chr6_112071150_112071301	0.18	FYN	FYN oncogene related to SRC, FGR, YES	9092	0.27
chr1_203733638_203733972	0.18	LAX1	lymphocyte transmembrane adaptor 1	499	0.77
chr9_117126749_117127269	0.18	AKNA	AT-hook transcription factor	12235	0.19
chr7_114646115_114646266	0.18	MDFIC	MyoD family inhibitor domain containing	72266	0.13
chr12_9449062_9449213	0.18	ENSG00000212440	.	9719	0.19
chr1_167791837_167791988	0.18	RP1-313L4.3		2268	0.35
chr20_8370040_8370204	0.18	PLCB1-IT1	PLCB1 intronic transcript 1 (non-protein coding)	140750	0.05
chr16_28584510_28584773	0.18	CCDC101	coiled-coil domain containing 101	17065	0.11
chr8_67518848_67519042	0.18	MYBL1	v-myb avian myeloblastosis viral oncogene homolog-like 1	6197	0.19
chr13_47195525_47195676	0.18	LRCH1	leucine-rich repeats and calponin homology (CH) domain containing 1	58371	0.15
chr13_36463957_36464108	0.18	DCLK1	doublecortin-like kinase 1	34253	0.24
chrX_8582050_8582201	0.18	KAL1	Kallmann syndrome 1 sequence	118102	0.06
chr1_1076072_1076302	0.18	C1orf159	chromosome 1 open reading frame 159	24446	0.07
chr15_63838577_63838728	0.18	USP3	ubiquitin specific peptidase 3	1828	0.36
chr19_3784822_3785395	0.18	MATK	megakaryocyte-associated tyrosine kinase	537	0.63
chr18_21589322_21589666	0.18	TTC39C	tetratricopeptide repeat domain 39C	4890	0.2
chr11_66058924_66059101	0.18	TMEM151A	transmembrane protein 151A	329	0.67
chr1_22438380_22438623	0.18	WNT4	wingless-type MMTV integration site family, member 4	17843	0.16
chr14_100560569_100560771	0.18	EVL	Enah/Vasp-like	2614	0.2
chr8_97163146_97163297	0.18	GDF6	growth differentiation factor 6	9799	0.25
chr9_91926652_91926816	0.18	ENSG00000265112	.	406	0.61
chr8_142413099_142413596	0.17	CTD-3064M3.4		10673	0.12
chr16_53550821_53550972	0.17	AKTIP	AKT interacting protein	12573	0.21
chr10_51503867_51504211	0.17	AGAP7	ArfGAP with GTPase domain, ankyrin repeat and PH domain 7	17712	0.18
chr21_29748389_29748540	0.17	ENSG00000251894	.	367066	0.01
chr3_169759548_169759699	0.17	GPR160	G protein-coupled receptor 160	3697	0.18
chr13_76341667_76341947	0.17	LMO7	LIM domain 7	7010	0.28
chr16_30918804_30919130	0.17	CTF1	cardiotrophin 1	11008	0.07
chr6_26385342_26385556	0.17	BTN2A2	butyrophilin, subfamily 2, member A2	1788	0.2
chr16_81502646_81502945	0.17	CMIP	c-Maf inducing protein	24020	0.23
chr7_72857019_72857170	0.17	FZD9	frizzled family receptor 9	8985	0.17
chr18_3264027_3264245	0.17	MYL12B	myosin, light chain 12B, regulatory	1182	0.39
chr16_88860278_88860577	0.17	PIEZO1	piezo-type mechanosensitive ion channel component 1	8808	0.09
chr5_102809102_102809289	0.17	NUDT12	nudix (nucleoside diphosphate linked moiety X)-type motif 12	89295	0.1
chr5_133439080_133439473	0.17	TCF7	transcription factor 7 (T-cell specific, HMG-box)	11126	0.22
chr9_80031789_80031940	0.17	VPS13A	vacuolar protein sorting 13 homolog A (S. cerevisiae)	10980	0.26
chr5_130725391_130725800	0.17	CDC42SE2	CDC42 small effector 2	4296	0.34
chr1_155939676_155940356	0.17	ARHGEF2	Rho/Rac guanine nucleotide exchange factor (GEF) 2	496	0.63
chr19_53603309_53603460	0.17	ZNF160	zinc finger protein 160	3220	0.18
chr4_4945545_4945811	0.17	ENSG00000200761	.	22887	0.22
chr19_47448802_47448953	0.17	ENSG00000252071	.	2669	0.25
chr5_169232621_169233022	0.17	CTB-37A13.1		26452	0.22
chr2_145279022_145279173	0.17	ZEB2	zinc finger E-box binding homeobox 2	476	0.7
chr22_46732320_46732471	0.17	TRMU	tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase	576	0.76
chr21_32508291_32508442	0.17	TIAM1	T-cell lymphoma invasion and metastasis 1	5827	0.3
chr12_65109271_65109422	0.17	AC025262.1	Mesenchymal stem cell protein DSC96; Uncharacterized protein	19017	0.13
chr4_1856936_1857463	0.17	LETM1	leucine zipper-EF-hand containing transmembrane protein 1	775	0.59
chr12_116999316_116999521	0.17	MAP1LC3B2	microtubule-associated protein 1 light chain 3 beta 2	2232	0.43
chr2_68615070_68615679	0.17	AC015969.3		22658	0.16
chr15_38847278_38847550	0.17	RASGRP1	RAS guanyl releasing protein 1 (calcium and DAG-regulated)	4869	0.21
chr19_54885852_54886183	0.17	LAIR1	leukocyte-associated immunoglobulin-like receptor 1	3852	0.13
chr18_43266623_43266884	0.17	SLC14A2	solute carrier family 14 (urea transporter), member 2	20646	0.17
chr3_67789239_67789462	0.17	SUCLG2	succinate-CoA ligase, GDP-forming, beta subunit	84312	0.1
chr18_74190035_74190186	0.17	ZNF516	zinc finger protein 516	12625	0.17
chr17_2577470_2577621	0.17	PAFAH1B1	platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)	3983	0.14
chr2_197114023_197114207	0.17	AC020571.3		10633	0.19
chr2_24843650_24843801	0.17	NCOA1	nuclear receptor coactivator 1	36315	0.16
chr15_38825178_38825329	0.17	RP11-275I4.1		8982	0.17
chr4_102210034_102210185	0.17	ENSG00000221265	.	41462	0.16
chr14_107179456_107179744	0.17	IGHV2-70	immunoglobulin heavy variable 2-70	262	0.7
chr2_167467162_167467351	0.16	SCN7A	sodium channel, voltage-gated, type VII, alpha subunit	116499	0.07
chr2_234178246_234178416	0.16	ENSG00000252010	.	6042	0.15
chr8_61730824_61730975	0.16	RP11-33I11.2		8734	0.29
chr20_1655973_1656235	0.16	ENSG00000242348	.	9098	0.16
chr1_229194417_229194588	0.16	RP5-1061H20.5		168807	0.03
chr15_62148457_62148639	0.16	RP11-16B9.1		21597	0.23
chr20_21537646_21537821	0.16	NKX2-2	NK2 homeobox 2	43069	0.16
chr17_30479138_30479373	0.16	AC090616.2	Uncharacterized protein	9101	0.13
chr5_88030594_88030850	0.16	CTC-467M3.2		42254	0.16
chr2_173375155_173375356	0.16	AC093818.1		1983	0.3
chr6_24918748_24919201	0.16	FAM65B	family with sequence similarity 65, member B	7779	0.24
chr11_63487782_63487933	0.16	RTN3	reticulon 3	38812	0.11
chr8_39797416_39797641	0.16	IDO2	indoleamine 2,3-dioxygenase 2	5054	0.18
chrX_13077716_13078009	0.16	FAM9C	family with sequence similarity 9, member C	15061	0.26
chr7_139465607_139465758	0.16	HIPK2	homeodomain interacting protein kinase 2	11835	0.23
chr4_36192264_36192495	0.16	ARAP2	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2	19988	0.24
chr3_176940409_176940560	0.16	TBL1XR1	transducin (beta)-like 1 X-linked receptor 1	25223	0.24
chr8_129664945_129665222	0.16	ENSG00000221351	.	166957	0.04
chr2_99120667_99121116	0.16	INPP4A	inositol polyphosphate-4-phosphatase, type I, 107kDa	15621	0.23
chr5_16608595_16608746	0.16	RP11-260E18.1		7365	0.19
chr1_66831872_66832123	0.16	PDE4B	phosphodiesterase 4B, cAMP-specific	11932	0.3
chr7_8054995_8055386	0.16	AC006042.7		45656	0.13
chr17_72516903_72517217	0.16	CD300LB	CD300 molecule-like family member b	10545	0.14
chr7_77614950_77615101	0.16	RP5-1185I7.1		4676	0.32
chr2_12410968_12411119	0.16	ENSG00000264089	.	71787	0.13
chr11_6742912_6743421	0.16	GVINP1	GTPase, very large interferon inducible pseudogene 1	55	0.96
chr4_85672938_85673089	0.16	WDFY3	WD repeat and FYVE domain containing 3	18398	0.22
chr17_78622247_78622398	0.16	RPTOR	regulatory associated protein of MTOR, complex 1	103054	0.06
chr1_42924324_42924527	0.16	PPCS	phosphopantothenoylcysteine synthetase	2193	0.24
chr21_17457844_17457995	0.16	ENSG00000252273	.	50090	0.19
chr10_43046062_43046288	0.16	ENSG00000251783	.	54431	0.14
chr13_28929966_28930249	0.16	FLT1	fms-related tyrosine kinase 1	9681	0.28
chr14_24522539_24522690	0.16	LRRC16B	leucine rich repeat containing 16B	1405	0.24
chr19_21646642_21646886	0.16	ZNF429	zinc finger protein 429	41602	0.16
chr10_11268288_11268534	0.16	RP3-323N1.2		55072	0.13
chr4_108973680_108973847	0.16	HADH	hydroxyacyl-CoA dehydrogenase	47972	0.14
chr2_62448746_62448902	0.16	B3GNT2	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	6171	0.18

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of PAX3

View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0019276	UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.1	0.4	GO:0033152	immunoglobulin V(D)J recombination(GO:0033152)
0.1	0.1	GO:0002326	B cell lineage commitment(GO:0002326)
0.1	0.3	GO:1901341	activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.1	0.3	GO:0010867	positive regulation of triglyceride biosynthetic process(GO:0010867)
0.1	0.3	GO:0001911	negative regulation of leukocyte mediated cytotoxicity(GO:0001911)
0.1	0.3	GO:0030854	positive regulation of granulocyte differentiation(GO:0030854)
0.1	0.1	GO:0002677	negative regulation of chronic inflammatory response(GO:0002677)
0.1	0.1	GO:0072600	protein targeting to Golgi(GO:0000042) establishment of protein localization to Golgi(GO:0072600)
0.0	0.2	GO:0045589	regulation of regulatory T cell differentiation(GO:0045589)
0.0	0.0	GO:0010572	positive regulation of platelet activation(GO:0010572)
0.0	0.0	GO:0050862	positive regulation of T cell receptor signaling pathway(GO:0050862)
0.0	0.2	GO:0030644	cellular chloride ion homeostasis(GO:0030644) chloride ion homeostasis(GO:0055064)
0.0	0.3	GO:0030206	chondroitin sulfate biosynthetic process(GO:0030206)
0.0	0.2	GO:0070670	response to interleukin-4(GO:0070670)
0.0	0.1	GO:0045722	positive regulation of gluconeogenesis(GO:0045722)
0.0	0.3	GO:0007172	signal complex assembly(GO:0007172)
0.0	0.1	GO:0018125	peptidyl-cysteine methylation(GO:0018125)
0.0	0.2	GO:0002313	mature B cell differentiation involved in immune response(GO:0002313)
0.0	0.1	GO:0046642	negative regulation of alpha-beta T cell proliferation(GO:0046642)
0.0	0.1	GO:0031936	negative regulation of chromatin silencing(GO:0031936)
0.0	0.1	GO:0017183	peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.0	0.1	GO:0031946	regulation of glucocorticoid biosynthetic process(GO:0031946)
0.0	1.0	GO:0050690	regulation of defense response to virus by virus(GO:0050690)
0.0	0.0	GO:0035234	ectopic germ cell programmed cell death(GO:0035234)
0.0	0.1	GO:0010447	response to acidic pH(GO:0010447)
0.0	0.1	GO:0060426	lung vasculature development(GO:0060426)
0.0	0.1	GO:0070672	response to interleukin-15(GO:0070672)
0.0	0.1	GO:0033622	integrin activation(GO:0033622)
0.0	0.4	GO:0032733	positive regulation of interleukin-10 production(GO:0032733)
0.0	0.4	GO:0030260	entry into host cell(GO:0030260) entry into host(GO:0044409) entry into cell of other organism involved in symbiotic interaction(GO:0051806) entry into other organism involved in symbiotic interaction(GO:0051828)
0.0	0.2	GO:0006198	cAMP catabolic process(GO:0006198)
0.0	0.0	GO:0002666	T cell tolerance induction(GO:0002517) regulation of T cell tolerance induction(GO:0002664) positive regulation of T cell tolerance induction(GO:0002666)
0.0	0.1	GO:0030812	negative regulation of nucleotide catabolic process(GO:0030812)
0.0	0.1	GO:0052169	pathogen-associated molecular pattern dependent induction by symbiont of host innate immune response(GO:0052033) positive regulation by symbiont of host innate immune response(GO:0052166) modulation by symbiont of host innate immune response(GO:0052167) pathogen-associated molecular pattern dependent modulation by symbiont of host innate immune response(GO:0052169) pathogen-associated molecular pattern dependent induction by organism of innate immune response of other organism involved in symbiotic interaction(GO:0052257) positive regulation by organism of innate immune response in other organism involved in symbiotic interaction(GO:0052305) modulation by organism of innate immune response in other organism involved in symbiotic interaction(GO:0052306) pathogen-associated molecular pattern dependent modulation by organism of innate immune response in other organism involved in symbiotic interaction(GO:0052308)
0.0	0.1	GO:0002323	natural killer cell activation involved in immune response(GO:0002323) natural killer cell degranulation(GO:0043320)
0.0	0.1	GO:0072216	positive regulation of metanephros development(GO:0072216)
0.0	0.1	GO:0060242	contact inhibition(GO:0060242)
0.0	0.0	GO:0002643	regulation of tolerance induction(GO:0002643) positive regulation of tolerance induction(GO:0002645)
0.0	0.1	GO:0010956	negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137)
0.0	0.1	GO:0051459	corticotropin secretion(GO:0051458) regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461)
0.0	0.1	GO:0046958	nonassociative learning(GO:0046958)
0.0	0.1	GO:0002507	tolerance induction(GO:0002507)
0.0	0.1	GO:0006855	drug transmembrane transport(GO:0006855)
0.0	0.1	GO:0045341	MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343)
0.0	0.0	GO:0033173	calcineurin-NFAT signaling cascade(GO:0033173)
0.0	0.1	GO:0051533	positive regulation of NFAT protein import into nucleus(GO:0051533)
0.0	0.1	GO:0006772	thiamine metabolic process(GO:0006772)
0.0	0.1	GO:0070498	interleukin-1-mediated signaling pathway(GO:0070498)
0.0	0.0	GO:0048541	Peyer's patch development(GO:0048541)
0.0	0.0	GO:0001661	conditioned taste aversion(GO:0001661)
0.0	0.0	GO:0030223	neutrophil differentiation(GO:0030223)
0.0	0.1	GO:0010452	histone H3-K36 methylation(GO:0010452)
0.0	0.1	GO:0007100	mitotic centrosome separation(GO:0007100)
0.0	0.0	GO:0033091	positive regulation of immature T cell proliferation(GO:0033091)
0.0	0.1	GO:0022614	membrane to membrane docking(GO:0022614)
0.0	0.1	GO:0060218	hematopoietic stem cell differentiation(GO:0060218)
0.0	0.0	GO:0032703	negative regulation of interleukin-2 production(GO:0032703)
0.0	0.1	GO:1901797	negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518) negative regulation of signal transduction by p53 class mediator(GO:1901797)
0.0	0.1	GO:0071481	cellular response to X-ray(GO:0071481)
0.0	0.1	GO:0034219	carbohydrate transmembrane transport(GO:0034219)
0.0	0.5	GO:0045576	mast cell activation(GO:0045576)
0.0	0.0	GO:0043300	regulation of leukocyte degranulation(GO:0043300)
0.0	0.2	GO:0043550	regulation of lipid kinase activity(GO:0043550)
0.0	0.1	GO:0031641	regulation of myelination(GO:0031641)
0.0	0.1	GO:0032927	positive regulation of activin receptor signaling pathway(GO:0032927)
0.0	0.0	GO:0046101	hypoxanthine biosynthetic process(GO:0046101)
0.0	0.1	GO:0002634	regulation of germinal center formation(GO:0002634)
0.0	0.2	GO:0040023	establishment of nucleus localization(GO:0040023)
0.0	0.1	GO:0033169	histone H3-K9 demethylation(GO:0033169)
0.0	0.2	GO:0008653	lipopolysaccharide metabolic process(GO:0008653)
0.0	0.1	GO:0034314	Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.0	0.1	GO:0015904	tetracycline transport(GO:0015904)
0.0	0.2	GO:0043368	positive T cell selection(GO:0043368)
0.0	0.1	GO:0015886	heme transport(GO:0015886)
0.0	0.1	GO:0001672	regulation of chromatin assembly or disassembly(GO:0001672)
0.0	0.1	GO:0070172	positive regulation of tooth mineralization(GO:0070172)
0.0	0.1	GO:0060437	lung growth(GO:0060437)
0.0	0.1	GO:0048261	negative regulation of receptor-mediated endocytosis(GO:0048261)
0.0	0.1	GO:0010159	specification of organ position(GO:0010159)
0.0	0.0	GO:0033632	regulation of cell-cell adhesion mediated by integrin(GO:0033632)
0.0	0.1	GO:0010759	positive regulation of macrophage chemotaxis(GO:0010759)
0.0	0.3	GO:0046579	positive regulation of Ras protein signal transduction(GO:0046579)
0.0	0.1	GO:0042989	sequestering of actin monomers(GO:0042989)
0.0	0.1	GO:0006032	chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.0	0.0	GO:0072217	negative regulation of metanephros development(GO:0072217)
0.0	0.1	GO:0000183	chromatin silencing at rDNA(GO:0000183)
0.0	0.1	GO:0060123	regulation of growth hormone secretion(GO:0060123)
0.0	0.1	GO:0010815	bradykinin catabolic process(GO:0010815)
0.0	0.0	GO:0002282	microglial cell activation involved in immune response(GO:0002282)
0.0	0.1	GO:0019228	neuronal action potential(GO:0019228)
0.0	0.1	GO:0050858	negative regulation of antigen receptor-mediated signaling pathway(GO:0050858) negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0	0.1	GO:0019934	cGMP-mediated signaling(GO:0019934)
0.0	0.2	GO:0043388	positive regulation of DNA binding(GO:0043388)
0.0	0.0	GO:0010592	positive regulation of lamellipodium assembly(GO:0010592) positive regulation of lamellipodium organization(GO:1902745)
0.0	0.0	GO:0036336	dendritic cell chemotaxis(GO:0002407) dendritic cell migration(GO:0036336)
0.0	0.6	GO:0034111	negative regulation of homotypic cell-cell adhesion(GO:0034111)
0.0	0.1	GO:0090224	regulation of spindle organization(GO:0090224)
0.0	0.0	GO:0052564	response to immune response of other organism involved in symbiotic interaction(GO:0052564) response to host immune response(GO:0052572)
0.0	0.2	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0	0.0	GO:0071379	cellular response to prostaglandin stimulus(GO:0071379)
0.0	0.1	GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process(GO:0051770)
0.0	0.1	GO:0033603	positive regulation of dopamine secretion(GO:0033603)
0.0	0.1	GO:0070682	proteasome regulatory particle assembly(GO:0070682)
0.0	0.0	GO:0032613	interleukin-10 production(GO:0032613)
0.0	0.1	GO:0045084	positive regulation of interleukin-12 biosynthetic process(GO:0045084)
0.0	0.0	GO:0097300	necroptotic process(GO:0070266) programmed necrotic cell death(GO:0097300)
0.0	0.1	GO:0043653	mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.0	0.1	GO:0050961	detection of temperature stimulus involved in sensory perception(GO:0050961) detection of temperature stimulus involved in sensory perception of pain(GO:0050965)
0.0	0.1	GO:0046477	glycosylceramide catabolic process(GO:0046477)
0.0	0.5	GO:1901185	negative regulation of epidermal growth factor receptor signaling pathway(GO:0042059) negative regulation of ERBB signaling pathway(GO:1901185)
0.0	0.2	GO:0000381	regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0	0.1	GO:0003215	cardiac right ventricle morphogenesis(GO:0003215)
0.0	0.1	GO:0050672	negative regulation of mononuclear cell proliferation(GO:0032945) negative regulation of lymphocyte proliferation(GO:0050672)
0.0	0.1	GO:0033522	histone H2A ubiquitination(GO:0033522)
0.0	0.2	GO:0042273	ribosomal large subunit biogenesis(GO:0042273)
0.0	0.1	GO:0042535	positive regulation of tumor necrosis factor biosynthetic process(GO:0042535)
0.0	0.0	GO:0032506	cytokinetic process(GO:0032506)
0.0	0.0	GO:0006925	inflammatory cell apoptotic process(GO:0006925)
0.0	0.0	GO:0009313	oligosaccharide catabolic process(GO:0009313)
0.0	0.0	GO:0035581	sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.0	0.0	GO:0051103	DNA ligation involved in DNA repair(GO:0051103)
0.0	0.1	GO:0050957	equilibrioception(GO:0050957)
0.0	0.1	GO:0006570	tyrosine metabolic process(GO:0006570)
0.0	0.1	GO:0008354	germ cell migration(GO:0008354)
0.0	0.1	GO:0008298	intracellular mRNA localization(GO:0008298)
0.0	0.1	GO:0043353	enucleate erythrocyte differentiation(GO:0043353)
0.0	0.1	GO:0052805	histidine catabolic process(GO:0006548) imidazole-containing compound catabolic process(GO:0052805)
0.0	0.1	GO:0006122	mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.0	0.0	GO:0016242	negative regulation of macroautophagy(GO:0016242)
0.0	0.0	GO:0009189	deoxyribonucleoside diphosphate biosynthetic process(GO:0009189)
0.0	0.1	GO:0006895	Golgi to endosome transport(GO:0006895) Golgi to vacuole transport(GO:0006896)
0.0	0.1	GO:0061756	leukocyte tethering or rolling(GO:0050901) leukocyte adhesion to vascular endothelial cell(GO:0061756)
0.0	0.1	GO:0008588	release of cytoplasmic sequestered NF-kappaB(GO:0008588)
0.0	0.0	GO:0015816	glycine transport(GO:0015816)
0.0	0.0	GO:0002888	regulation of myeloid leukocyte mediated immunity(GO:0002886) positive regulation of myeloid leukocyte mediated immunity(GO:0002888)
0.0	0.0	GO:2000831	corticosteroid hormone secretion(GO:0035930) regulation of steroid hormone secretion(GO:2000831) regulation of corticosteroid hormone secretion(GO:2000846)
0.0	0.1	GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway(GO:0007195)
0.0	0.0	GO:0034063	stress granule assembly(GO:0034063)
0.0	0.1	GO:0034755	iron ion transmembrane transport(GO:0034755)
0.0	0.0	GO:0010980	regulation of vitamin D 24-hydroxylase activity(GO:0010979) positive regulation of vitamin D 24-hydroxylase activity(GO:0010980)
0.0	0.0	GO:0021778	spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) oligodendrocyte cell fate specification(GO:0021778) glial cell fate specification(GO:0021780)
0.0	0.0	GO:0042339	keratan sulfate metabolic process(GO:0042339)
0.0	0.1	GO:0050908	detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.0	0.1	GO:0030490	maturation of SSU-rRNA(GO:0030490)
0.0	0.0	GO:0042996	regulation of Golgi to plasma membrane protein transport(GO:0042996)
0.0	0.1	GO:0007007	inner mitochondrial membrane organization(GO:0007007)
0.0	0.0	GO:1901072	amino sugar catabolic process(GO:0046348) glucosamine-containing compound catabolic process(GO:1901072)
0.0	0.1	GO:0000380	alternative mRNA splicing, via spliceosome(GO:0000380)
0.0	0.1	GO:0033119	negative regulation of RNA splicing(GO:0033119)
0.0	0.1	GO:0000098	sulfur amino acid catabolic process(GO:0000098)
0.0	0.1	GO:0006477	protein sulfation(GO:0006477)
0.0	0.0	GO:0051057	positive regulation of small GTPase mediated signal transduction(GO:0051057)
0.0	0.1	GO:0045078	positive regulation of interferon-gamma biosynthetic process(GO:0045078)
0.0	0.1	GO:0006432	phenylalanyl-tRNA aminoacylation(GO:0006432)
0.0	0.0	GO:0045075	interleukin-12 biosynthetic process(GO:0042090) regulation of interleukin-12 biosynthetic process(GO:0045075)
0.0	0.1	GO:0006003	fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0	0.0	GO:0009106	lipoate metabolic process(GO:0009106)
0.0	0.0	GO:0007221	positive regulation of transcription of Notch receptor target(GO:0007221)
0.0	0.1	GO:0009414	response to water deprivation(GO:0009414) response to water(GO:0009415)
0.0	0.1	GO:0045061	thymic T cell selection(GO:0045061)
0.0	0.1	GO:0070570	regulation of axon regeneration(GO:0048679) regulation of neuron projection regeneration(GO:0070570)
0.0	0.1	GO:1901976	regulation of cell cycle checkpoint(GO:1901976)
0.0	0.0	GO:0018119	protein nitrosylation(GO:0017014) peptidyl-cysteine S-nitrosylation(GO:0018119)
0.0	0.0	GO:0046502	uroporphyrinogen III metabolic process(GO:0046502)
0.0	0.1	GO:0006491	N-glycan processing(GO:0006491)
0.0	0.0	GO:0006104	succinyl-CoA metabolic process(GO:0006104)
0.0	0.0	GO:0061640	cytoskeleton-dependent cytokinesis(GO:0061640)
0.0	0.0	GO:0034625	fatty acid elongation, monounsaturated fatty acid(GO:0034625)
0.0	0.2	GO:0050832	defense response to fungus(GO:0050832)
0.0	0.1	GO:0034643	establishment of mitochondrion localization, microtubule-mediated(GO:0034643) mitochondrion transport along microtubule(GO:0047497)
0.0	0.1	GO:0006545	glycine biosynthetic process(GO:0006545)
0.0	0.0	GO:0051299	centrosome separation(GO:0051299)
0.0	0.1	GO:0000303	response to superoxide(GO:0000303)
0.0	0.0	GO:0002031	G-protein coupled receptor internalization(GO:0002031)
0.0	0.0	GO:0045657	positive regulation of monocyte differentiation(GO:0045657)
0.0	0.0	GO:0045603	positive regulation of endothelial cell differentiation(GO:0045603)
0.0	0.0	GO:0021830	interneuron migration from the subpallium to the cortex(GO:0021830) cerebral cortex GABAergic interneuron migration(GO:0021853) cerebral cortex GABAergic interneuron development(GO:0021894) interneuron migration(GO:1904936)
0.0	0.1	GO:0007130	synaptonemal complex assembly(GO:0007130)
0.0	0.1	GO:0033158	regulation of protein import into nucleus, translocation(GO:0033158)
0.0	0.0	GO:0032627	interleukin-23 production(GO:0032627) regulation of interleukin-23 production(GO:0032667) positive regulation of interleukin-23 production(GO:0032747)
0.0	0.0	GO:0045672	positive regulation of osteoclast differentiation(GO:0045672)
0.0	0.0	GO:0042510	regulation of tyrosine phosphorylation of Stat1 protein(GO:0042510)
0.0	0.0	GO:0008054	negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation(GO:0008054)
0.0	0.1	GO:0002483	antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.0	0.0	GO:0008628	hormone-mediated apoptotic signaling pathway(GO:0008628)
0.0	0.1	GO:0006685	sphingomyelin catabolic process(GO:0006685)
0.0	0.0	GO:0035610	C-terminal protein deglutamylation(GO:0035609) protein side chain deglutamylation(GO:0035610)
0.0	0.0	GO:0034720	histone H3-K4 demethylation(GO:0034720)
0.0	0.0	GO:0034122	negative regulation of toll-like receptor signaling pathway(GO:0034122)
0.0	0.1	GO:0071168	protein localization to chromatin(GO:0071168)
0.0	0.0	GO:0002238	response to molecule of fungal origin(GO:0002238)
0.0	0.1	GO:0051923	sulfation(GO:0051923)
0.0	0.1	GO:0090114	vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208) COPII-coated vesicle budding(GO:0090114)
0.0	0.0	GO:0006667	sphinganine metabolic process(GO:0006667)

Gene overrepresentation in cellular component category:

Total log-likelihood	Term	Description
0.1	GO:0042105	alpha-beta T cell receptor complex(GO:0042105)
0.3	GO:0001891	phagocytic cup(GO:0001891)
0.3	GO:0010494	cytoplasmic stress granule(GO:0010494)
0.2	GO:0045240	dihydrolipoyl dehydrogenase complex(GO:0045240)
0.1	GO:0032591	dendritic spine membrane(GO:0032591)
0.1	GO:0032009	early phagosome(GO:0032009)
0.1	GO:0032045	guanyl-nucleotide exchange factor complex(GO:0032045)
0.1	GO:0033553	rDNA heterochromatin(GO:0033553)
0.3	GO:0071203	WASH complex(GO:0071203)
0.8	GO:0030175	filopodium(GO:0030175)
0.1	GO:0072669	tRNA-splicing ligase complex(GO:0072669)
0.1	GO:0031088	platelet dense granule membrane(GO:0031088)
0.1	GO:0005672	transcription factor TFIIA complex(GO:0005672)
0.1	GO:0005954	calcium- and calmodulin-dependent protein kinase complex(GO:0005954)
0.1	GO:0042629	mast cell granule(GO:0042629)
0.1	GO:0008540	proteasome regulatory particle, base subcomplex(GO:0008540)
0.1	GO:0048179	activin receptor complex(GO:0048179)
0.1	GO:0045323	interleukin-1 receptor complex(GO:0045323)
0.1	GO:0000300	obsolete peripheral to membrane of membrane fraction(GO:0000300)
0.0	GO:0070022	transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.1	GO:0070695	FHF complex(GO:0070695)
0.1	GO:0000137	Golgi cis cisterna(GO:0000137)
0.1	GO:0005638	lamin filament(GO:0005638)
0.1	GO:0070776	H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0	GO:0030062	mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.0	GO:0071438	invadopodium membrane(GO:0071438)
0.1	GO:0014731	spectrin-associated cytoskeleton(GO:0014731)
0.1	GO:0033162	melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.0	GO:0071437	invadopodium(GO:0071437)
0.0	GO:0000942	condensed nuclear chromosome outer kinetochore(GO:0000942)
0.0	GO:1990316	ATG1/ULK1 kinase complex(GO:1990316)
0.2	GO:0005942	phosphatidylinositol 3-kinase complex(GO:0005942)
0.1	GO:0030127	COPII vesicle coat(GO:0030127)
0.0	GO:0005686	U2 snRNP(GO:0005686)
0.1	GO:0005838	proteasome regulatory particle(GO:0005838)
0.2	GO:0030914	STAGA complex(GO:0030914)
0.1	GO:0000421	autophagosome membrane(GO:0000421)
0.2	GO:0019005	SCF ubiquitin ligase complex(GO:0019005)
0.0	GO:0000407	pre-autophagosomal structure(GO:0000407) pre-autophagosomal structure membrane(GO:0034045)
0.0	GO:0031371	ubiquitin conjugating enzyme complex(GO:0031371)
0.1	GO:0000153	cytoplasmic ubiquitin ligase complex(GO:0000153)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0047238	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.1	0.4	GO:0016494	C-X-C chemokine receptor activity(GO:0016494)
0.1	0.2	GO:0016309	1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.1	0.4	GO:0030676	Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.1	0.2	GO:0047756	chondroitin 4-sulfotransferase activity(GO:0047756)
0.0	0.2	GO:0032454	histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0	0.1	GO:0004167	dopachrome isomerase activity(GO:0004167)
0.0	0.1	GO:0016842	amidine-lyase activity(GO:0016842)
0.0	0.1	GO:0004465	lipoprotein lipase activity(GO:0004465)
0.0	0.2	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.0	0.2	GO:0042043	neurexin family protein binding(GO:0042043)
0.0	0.1	GO:0017159	pantetheine hydrolase activity(GO:0017159)
0.0	0.1	GO:0033691	sialic acid binding(GO:0033691)
0.0	0.1	GO:0015562	efflux transmembrane transporter activity(GO:0015562)
0.0	0.1	GO:0032296	ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296)
0.0	0.2	GO:0046790	virion binding(GO:0046790)
0.0	0.1	GO:0052658	inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658) inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity(GO:0052659)
0.0	0.4	GO:0004950	G-protein coupled chemoattractant receptor activity(GO:0001637) chemokine receptor activity(GO:0004950)
0.0	0.1	GO:0034236	protein kinase A catalytic subunit binding(GO:0034236)
0.0	0.1	GO:0019834	phospholipase A2 inhibitor activity(GO:0019834)
0.0	0.1	GO:0035197	siRNA binding(GO:0035197)
0.0	0.0	GO:0016312	inositol bisphosphate phosphatase activity(GO:0016312)
0.0	0.1	GO:0003987	acetate-CoA ligase activity(GO:0003987)
0.0	0.1	GO:0004969	histamine receptor activity(GO:0004969)
0.0	0.1	GO:0015520	tetracycline:proton antiporter activity(GO:0015520)
0.0	0.1	GO:0047894	flavonol 3-sulfotransferase activity(GO:0047894)
0.0	0.1	GO:0004911	interleukin-2 receptor activity(GO:0004911)
0.0	0.1	GO:0008545	JUN kinase kinase activity(GO:0008545)
0.0	0.5	GO:0045028	G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0	0.9	GO:0004715	non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0	0.1	GO:0034237	protein kinase A regulatory subunit binding(GO:0034237)
0.0	0.1	GO:0015232	heme transporter activity(GO:0015232)
0.0	0.1	GO:0019215	intermediate filament binding(GO:0019215)
0.0	0.1	GO:0042799	histone methyltransferase activity (H4-K20 specific)(GO:0042799)
0.0	0.1	GO:0004064	arylesterase activity(GO:0004064)
0.0	0.1	GO:0004568	chitinase activity(GO:0004568)
0.0	0.2	GO:0019864	IgG binding(GO:0019864)
0.0	0.1	GO:0043539	protein serine/threonine kinase activator activity(GO:0043539)
0.0	0.1	GO:0005094	Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0	0.1	GO:0030375	thyroid hormone receptor coactivator activity(GO:0030375)
0.0	0.1	GO:0015925	galactosidase activity(GO:0015925)
0.0	0.1	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0	0.1	GO:0042156	obsolete zinc-mediated transcriptional activator activity(GO:0042156)
0.0	0.1	GO:0030955	potassium ion binding(GO:0030955)
0.0	0.1	GO:0004591	oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.0	0.1	GO:0004677	DNA-dependent protein kinase activity(GO:0004677)
0.0	0.1	GO:0046974	histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.0	0.2	GO:0004467	long-chain fatty acid-CoA ligase activity(GO:0004467)
0.0	0.0	GO:0042577	lipid phosphatase activity(GO:0042577)
0.0	0.1	GO:0005381	iron ion transmembrane transporter activity(GO:0005381)
0.0	0.1	GO:0004904	interferon receptor activity(GO:0004904)
0.0	0.1	GO:0001595	angiotensin receptor activity(GO:0001595) angiotensin type II receptor activity(GO:0004945)
0.0	0.0	GO:0043559	insulin binding(GO:0043559)
0.0	0.1	GO:0005092	GDP-dissociation inhibitor activity(GO:0005092)
0.0	0.2	GO:0005031	tumor necrosis factor-activated receptor activity(GO:0005031)
0.0	0.0	GO:0034481	chondroitin sulfotransferase activity(GO:0034481)
0.0	0.0	GO:0016748	succinyltransferase activity(GO:0016748)
0.0	0.0	GO:0004774	succinate-CoA ligase activity(GO:0004774)
0.0	0.1	GO:0070097	delta-catenin binding(GO:0070097)
0.0	0.1	GO:0050700	CARD domain binding(GO:0050700)
0.0	0.0	GO:0004514	nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514)
0.0	0.3	GO:0042169	SH2 domain binding(GO:0042169)
0.0	0.1	GO:0070053	thrombospondin receptor activity(GO:0070053)
0.0	0.0	GO:0004556	alpha-amylase activity(GO:0004556) amylase activity(GO:0016160)
0.0	0.2	GO:0005095	GTPase inhibitor activity(GO:0005095)
0.0	0.1	GO:0016670	oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor(GO:0016670)
0.0	0.1	GO:0050733	RS domain binding(GO:0050733)
0.0	0.2	GO:0031593	polyubiquitin binding(GO:0031593)
0.0	0.1	GO:0004908	interleukin-1 receptor activity(GO:0004908)
0.0	0.1	GO:0042285	UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285)
0.0	0.1	GO:0004955	prostaglandin receptor activity(GO:0004955)
0.0	0.1	GO:0016624	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor(GO:0016624)
0.0	0.0	GO:0004946	bombesin receptor activity(GO:0004946)
0.0	0.1	GO:0004704	NF-kappaB-inducing kinase activity(GO:0004704)
0.0	0.1	GO:0004826	phenylalanine-tRNA ligase activity(GO:0004826)
0.0	0.1	GO:0003873	6-phosphofructo-2-kinase activity(GO:0003873)
0.0	0.1	GO:0070513	death domain binding(GO:0070513)
0.0	0.1	GO:0030284	estrogen receptor activity(GO:0030284)
0.0	0.1	GO:0070087	chromo shadow domain binding(GO:0070087)
0.0	0.2	GO:0005164	tumor necrosis factor receptor binding(GO:0005164)
0.0	0.0	GO:0004967	glucagon receptor activity(GO:0004967)
0.0	0.1	GO:0004952	dopamine neurotransmitter receptor activity(GO:0004952)
0.0	0.1	GO:0016833	oxo-acid-lyase activity(GO:0016833)
0.0	0.1	GO:0060228	phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
0.0	0.0	GO:0070644	vitamin D response element binding(GO:0070644)
0.0	0.1	GO:0003688	DNA replication origin binding(GO:0003688)
0.0	0.1	GO:0008175	tRNA methyltransferase activity(GO:0008175)
0.0	0.0	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.0	0.0	GO:0034711	inhibin binding(GO:0034711)
0.0	0.0	GO:0015037	peptide disulfide oxidoreductase activity(GO:0015037)
0.0	0.0	GO:0015467	G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0	0.0	GO:0004340	glucokinase activity(GO:0004340)
0.0	0.1	GO:0008191	metalloendopeptidase inhibitor activity(GO:0008191)
0.0	0.1	GO:0008526	phosphatidylinositol transporter activity(GO:0008526)
0.0	0.1	GO:0001784	phosphotyrosine binding(GO:0001784)
0.0	0.0	GO:0032453	histone demethylase activity (H3-K4 specific)(GO:0032453) histone demethylase activity (H3-dimethyl-K4 specific)(GO:0034648)
0.0	0.0	GO:0002060	purine nucleobase binding(GO:0002060)
0.0	0.1	GO:0030275	LRR domain binding(GO:0030275)
0.0	0.1	GO:0008467	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0	0.0	GO:0003953	NAD+ nucleosidase activity(GO:0003953)
0.0	0.1	GO:0032407	MutSalpha complex binding(GO:0032407)
0.0	0.0	GO:0008493	tetracycline transporter activity(GO:0008493)
0.0	0.0	GO:0042978	ornithine decarboxylase activator activity(GO:0042978)
0.0	0.0	GO:0005536	glucose binding(GO:0005536)
0.0	0.2	GO:0004364	glutathione transferase activity(GO:0004364)
0.0	0.1	GO:0019992	diacylglycerol binding(GO:0019992)
0.0	0.1	GO:0008079	translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.0	0.0	GO:0019870	potassium channel inhibitor activity(GO:0019870)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
1.0	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
0.5	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.3	ST TYPE I INTERFERON PATHWAY	Type I Interferon (alpha/beta IFN) Pathway
0.4	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.8	PID ERBB1 INTERNALIZATION PATHWAY	Internalization of ErbB1
0.6	PID IL8 CXCR2 PATHWAY	IL8- and CXCR2-mediated signaling events
0.9	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
0.7	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.4	PID IL1 PATHWAY	IL1-mediated signaling events
0.2	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.4	PID IL6 7 PATHWAY	IL6-mediated signaling events
0.4	PID CDC42 REG PATHWAY	Regulation of CDC42 activity
0.1	PID TCR CALCIUM PATHWAY	Calcium signaling in the CD4+ TCR pathway
0.0	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
0.0	ST INTERFERON GAMMA PATHWAY	Interferon gamma pathway.
0.0	PID IGF1 PATHWAY	IGF1 pathway
0.2	PID BCR 5PATHWAY	BCR signaling pathway
0.1	PID NFKAPPAB CANONICAL PATHWAY	Canonical NF-kappaB pathway
0.1	PID ER NONGENOMIC PATHWAY	Plasma membrane estrogen receptor signaling
0.0	PID CXCR3 PATHWAY	CXCR3-mediated signaling events
0.1	PID ERB GENOMIC PATHWAY	Validated nuclear estrogen receptor beta network
0.2	PID FCER1 PATHWAY	Fc-epsilon receptor I signaling in mast cells
0.1	PID FAS PATHWAY	FAS (CD95) signaling pathway
0.0	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.1	0.6	REACTOME CD28 DEPENDENT VAV1 PATHWAY	Genes involved in CD28 dependent Vav1 pathway
0.0	0.0	REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE	Genes involved in Translocation of ZAP-70 to Immunological synapse
0.0	0.0	REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Glutamate Neurotransmitter Release Cycle
0.0	0.4	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
0.0	0.4	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0	0.8	REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0	0.1	REACTOME TRAF6 MEDIATED NFKB ACTIVATION	Genes involved in TRAF6 mediated NF-kB activation
0.0	0.5	REACTOME GPVI MEDIATED ACTIVATION CASCADE	Genes involved in GPVI-mediated activation cascade
0.0	0.2	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING	Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.0	0.0	REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY	Genes involved in TRAF3-dependent IRF activation pathway
0.0	0.2	REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION	Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.0	0.4	REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS	Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.0	0.2	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.0	0.2	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.0	0.4	REACTOME CHONDROITIN SULFATE BIOSYNTHESIS	Genes involved in Chondroitin sulfate biosynthesis
0.0	0.1	REACTOME CTLA4 INHIBITORY SIGNALING	Genes involved in CTLA4 inhibitory signaling
0.0	0.2	REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX	Genes involved in Association of licensing factors with the pre-replicative complex
0.0	0.3	REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0	0.1	REACTOME PROSTANOID LIGAND RECEPTORS	Genes involved in Prostanoid ligand receptors
0.0	0.2	REACTOME PROLACTIN RECEPTOR SIGNALING	Genes involved in Prolactin receptor signaling
0.0	0.3	REACTOME IL 2 SIGNALING	Genes involved in Interleukin-2 signaling
0.0	0.1	REACTOME HYALURONAN UPTAKE AND DEGRADATION	Genes involved in Hyaluronan uptake and degradation
0.0	0.1	REACTOME ROLE OF DCC IN REGULATING APOPTOSIS	Genes involved in Role of DCC in regulating apoptosis
0.0	0.1	REACTOME REGULATION OF INSULIN SECRETION BY GLUCAGON LIKE PEPTIDE1	Genes involved in Regulation of Insulin Secretion by Glucagon-like Peptide-1
0.0	0.1	REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS	Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0	0.2	REACTOME N GLYCAN ANTENNAE ELONGATION	Genes involved in N-Glycan antennae elongation
0.0	0.0	REACTOME ABACAVIR TRANSPORT AND METABOLISM	Genes involved in Abacavir transport and metabolism
0.0	0.1	REACTOME SPRY REGULATION OF FGF SIGNALING	Genes involved in Spry regulation of FGF signaling
0.0	0.2	REACTOME EFFECTS OF PIP2 HYDROLYSIS	Genes involved in Effects of PIP2 hydrolysis
0.0	0.0	REACTOME G1 S SPECIFIC TRANSCRIPTION	Genes involved in G1/S-Specific Transcription
0.0	0.1	REACTOME ACTIVATION OF RAC	Genes involved in Activation of Rac
0.0	0.1	REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP	Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0	0.6	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0	0.2	REACTOME G0 AND EARLY G1	Genes involved in G0 and Early G1
0.0	0.1	REACTOME ACTIVATION OF BH3 ONLY PROTEINS	Genes involved in Activation of BH3-only proteins
0.0	0.2	REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA	Genes involved in Circadian Repression of Expression by REV-ERBA
0.0	0.4	REACTOME GLYCOSPHINGOLIPID METABOLISM	Genes involved in Glycosphingolipid metabolism
0.0	0.1	REACTOME CTNNB1 PHOSPHORYLATION CASCADE	Genes involved in Beta-catenin phosphorylation cascade