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ENCODE: H3K4me1 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for PAX6

Z-value: 1.43

Motif logo

Transcription factors associated with PAX6

Gene Symbol	Gene ID	Gene Info
PAX6 Ensembl NCBI GeneCards UniProt	ENSG00000007372.16	PAX6

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
PAX6	chr11_31826577_31826894	1734	0.380474	-0.86	2.6e-03	Click!
PAX6	chr11_31833001_31833196	127	0.920977	-0.86	3.1e-03	Click!
PAX6	chr11_31832818_31833000	30	0.959923	-0.77	1.6e-02	Click!
PAX6	chr11_31825613_31825877	2724	0.284551	-0.72	2.8e-02	Click!
PAX6	chr11_31825003_31825154	3391	0.256420	-0.71	3.2e-02	Click!

Activity of the PAX6 motif across conditions

Conditions sorted by the z-value of the PAX6 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr13_37492421_37492572	0.48	SMAD9	SMAD family member 9	1879	0.38
chr4_3205185_3205539	0.43	MSANTD1	Myb/SANT-like DNA-binding domain containing 1	40734	0.15
chr10_6390281_6390901	0.42	DKFZP667F0711		1687	0.47
chr15_74607384_74607800	0.35	CCDC33	coiled-coil domain containing 33	3308	0.2
chr6_37903547_37903776	0.35	ZFAND3	zinc finger, AN1-type domain 3	5926	0.24
chr10_24911730_24912041	0.34	ARHGAP21	Rho GTPase activating protein 21	122	0.97
chr13_74701587_74701980	0.32	KLF12	Kruppel-like factor 12	6611	0.34
chr4_15768464_15768936	0.31	CD38	CD38 molecule	11201	0.22
chr8_59837028_59837179	0.30	RP11-328K2.1		68394	0.12
chr1_110644690_110645263	0.29	UBL4B	ubiquitin-like 4B	10086	0.12
chr13_94979274_94979692	0.28	ENSG00000212057	.	138161	0.05
chr12_92691247_92691679	0.28	RP11-693J15.4		123844	0.05
chr12_110386988_110387317	0.28	GIT2	G protein-coupled receptor kinase interacting ArfGAP 2	46877	0.1
chr12_92692622_92693037	0.27	RP11-693J15.4		122478	0.05
chr5_158246848_158247336	0.27	CTD-2363C16.1		162922	0.04
chrX_78363858_78364080	0.27	GPR174	G protein-coupled receptor 174	62500	0.15
chr2_223474492_223474643	0.26	RP11-16P6.1		40129	0.14
chr1_65293370_65293571	0.26	RAVER2	ribonucleoprotein, PTB-binding 2	49723	0.17
chr15_85465174_85465325	0.25	ENSG00000207037	.	16504	0.15
chr16_57021435_57021712	0.25	NLRC5	NLR family, CARD domain containing 5	1837	0.25
chr3_46017069_46017657	0.25	FYCO1	FYVE and coiled-coil domain containing 1	9124	0.18
chr6_126131633_126131847	0.24	NCOA7	nuclear receptor coactivator 7	459	0.82
chr18_46578900_46579398	0.24	ENSG00000263849	.	3011	0.26
chr8_22467250_22467401	0.24	CCAR2	cell cycle and apoptosis regulator 2	2891	0.14
chr8_126944858_126945009	0.24	ENSG00000206695	.	31738	0.25
chr1_66818044_66818301	0.24	PDE4B	phosphodiesterase 4B, cAMP-specific	1893	0.49
chrX_111880061_111880212	0.24	ENSG00000200436	.	24749	0.22
chr2_8465178_8465329	0.24	AC011747.7		350643	0.01
chr11_128352992_128353212	0.24	ETS1	v-ets avian erythroblastosis virus E26 oncogene homolog 1	22187	0.23
chr1_198639009_198639295	0.24	RP11-553K8.5		2962	0.33
chr3_56955616_56956051	0.24	ARHGEF3	Rho guanine nucleotide exchange factor (GEF) 3	5334	0.25
chr10_120101185_120101336	0.24	FAM204A	family with sequence similarity 204, member A	492	0.89
chr16_4463178_4463503	0.23	CORO7	coronin 7	150	0.93
chr2_198116416_198116939	0.23	ANKRD44-IT1	ANKRD44 intronic transcript 1 (non-protein coding)	50566	0.11
chr8_90802794_90803092	0.23	RIPK2	receptor-interacting serine-threonine kinase 2	32881	0.22
chr6_143177440_143177974	0.23	HIVEP2	human immunodeficiency virus type I enhancer binding protein 2	19523	0.26
chr13_21371232_21371529	0.23	N6AMT2	N-6 adenine-specific DNA methyltransferase 2 (putative)	23292	0.2
chr1_235098252_235098681	0.23	ENSG00000239690	.	58533	0.14
chr20_43646840_43647043	0.23	ENSG00000252021	.	13952	0.16
chr2_10472354_10472745	0.23	HPCAL1	hippocalcin-like 1	28723	0.15
chr7_116646128_116646279	0.23	ST7	suppression of tumorigenicity 7	8739	0.17
chr1_172677197_172677413	0.23	FASLG	Fas ligand (TNF superfamily, member 6)	49147	0.17
chr19_39355210_39355462	0.23	RINL	Ras and Rab interactor-like	5225	0.08
chr1_198568049_198568225	0.23	PTPRC	protein tyrosine phosphatase, receptor type, C	39664	0.18
chr15_48839437_48839588	0.23	FBN1	fibrillin 1	98406	0.08
chr2_204569227_204569393	0.23	CD28	CD28 molecule	1888	0.43
chr17_64786718_64786990	0.23	ENSG00000207943	.	3664	0.27
chr1_92178896_92179392	0.22	ENSG00000239794	.	116487	0.06
chr1_240399314_240399591	0.22	FMN2	formin 2	9108	0.25
chr11_61311867_61312018	0.22	LRRC10B	leucine rich repeat containing 10B	35670	0.11
chr3_123414639_123414914	0.22	MYLK	myosin light chain kinase	3550	0.22
chr20_31026727_31027014	0.22	ASXL1	additional sex combs like 1 (Drosophila)	8205	0.18
chr1_93418442_93418689	0.22	FAM69A	family with sequence similarity 69, member A	8492	0.13
chr12_92405753_92405904	0.22	C12orf79	chromosome 12 open reading frame 79	124969	0.05
chr9_117500179_117500330	0.22	TNFSF15	tumor necrosis factor (ligand) superfamily, member 15	54134	0.12
chr5_74344978_74345129	0.22	GCNT4	glucosaminyl (N-acetyl) transferase 4, core 2	18329	0.26
chr5_10235322_10235473	0.22	CTD-2256P15.1		13040	0.14
chr2_158327174_158327325	0.22	CYTIP	cytohesin 1 interacting protein	18092	0.22
chr22_42570325_42570627	0.22	RP4-669P10.16		34538	0.1
chr9_132474851_132475112	0.22	RP11-483H20.6		5933	0.17
chr10_104469959_104470110	0.22	ARL3	ADP-ribosylation factor-like 3	4130	0.17
chr7_96466534_96466857	0.21	ENSG00000244318	.	102981	0.07
chr7_76905636_76905787	0.21	AC073635.5		18271	0.21
chrX_38667654_38667898	0.21	MID1IP1-AS1	MID1IP1 antisense RNA 1	4640	0.26
chr11_122941610_122941891	0.21	HSPA8	heat shock 70kDa protein 8	7812	0.15
chr6_11724594_11724763	0.21	ADTRP	androgen-dependent TFPI-regulating protein	11211	0.23
chr1_92345001_92345152	0.21	TGFBR3	transforming growth factor, beta receptor III	6590	0.23
chr2_216523684_216523835	0.21	ENSG00000212055	.	219883	0.02
chr5_8730409_8730560	0.21	ENSG00000247516	.	269446	0.02
chr9_73179803_73180006	0.21	ENSG00000272232	.	14473	0.27
chr18_46328142_46328344	0.21	RP11-484L8.1		32898	0.21
chr11_95869941_95870432	0.21	ENSG00000266192	.	204416	0.02
chr12_104913378_104913669	0.21	CHST11	carbohydrate (chondroitin 4) sulfotransferase 11	62744	0.13
chr1_199138552_199138703	0.21	ENSG00000239006	.	27685	0.27
chr20_62642811_62642962	0.21	ZNF512B	zinc finger protein 512B	27052	0.07
chr17_14239751_14239963	0.21	HS3ST3B1	heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1	35457	0.21
chr13_79975449_79975617	0.21	RBM26	RNA binding motif protein 26	4390	0.21
chr2_158752002_158752244	0.20	ENSG00000251980	.	17161	0.16
chr2_218806773_218807050	0.20	TNS1	tensin 1	1882	0.39
chr4_149305859_149306010	0.20	NR3C2	nuclear receptor subfamily 3, group C, member 2	52078	0.18
chr14_62265738_62265889	0.20	SNAPC1	small nuclear RNA activating complex, polypeptide 1, 43kDa	36738	0.21
chr3_71102554_71102705	0.20	FOXP1	forkhead box P1	11448	0.31
chr11_108067830_108068158	0.20	ATM	ataxia telangiectasia mutated	25217	0.14
chr4_119094964_119095281	0.20	ENSG00000269893	.	105223	0.08
chr12_103835916_103836067	0.20	C12orf42	chromosome 12 open reading frame 42	53740	0.15
chr2_12460574_12460725	0.20	ENSG00000207183	.	90978	0.09
chr16_23517170_23517321	0.20	GGA2	golgi-associated, gamma adaptin ear containing, ARF binding protein 2	4465	0.17
chr4_84271786_84272009	0.20	HPSE	heparanase	15591	0.23
chrX_112799748_112799899	0.20	ENSG00000201674	.	387868	0.01
chr7_129522852_129523003	0.20	UBE2H	ubiquitin-conjugating enzyme E2H	68240	0.07
chr6_16322559_16323009	0.20	GMPR	guanosine monophosphate reductase	83973	0.08
chr16_48266324_48266475	0.20	ABCC11	ATP-binding cassette, sub-family C (CFTR/MRP), member 11	217	0.94
chr1_98368924_98369075	0.20	DPYD	dihydropyrimidine dehydrogenase	17554	0.28
chr3_182631499_182631955	0.20	RP11-531F16.4		7999	0.21
chr9_133699234_133699385	0.20	ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	11144	0.23
chr7_105681414_105681565	0.20	CDHR3	cadherin-related family member 3	25919	0.22
chr20_8737721_8737915	0.19	PLCB1	phospholipase C, beta 1 (phosphoinositide-specific)	20143	0.25
chr3_56705961_56706112	0.19	FAM208A	family with sequence similarity 208, member A	7677	0.29
chr4_159699937_159700088	0.19	FNIP2	folliculin interacting protein 2	9722	0.19
chr2_106491036_106491228	0.19	AC009505.2		17499	0.23
chr17_41245934_41246085	0.19	BRCA1	breast cancer 1, early onset	1874	0.25
chr4_79578092_79578243	0.19	ENSG00000238816	.	16913	0.2
chr2_158345197_158345348	0.19	CYTIP	cytohesin 1 interacting protein	69	0.98
chr11_116796998_116797221	0.19	SIK3	SIK family kinase 3	30651	0.13
chr6_108107829_108108113	0.19	SCML4	sex comb on midleg-like 4 (Drosophila)	14516	0.27
chr6_42540352_42540503	0.19	UBR2	ubiquitin protein ligase E3 component n-recognin 2	8627	0.22
chr12_32278121_32278272	0.19	RP11-843B15.2		17734	0.21
chr10_30992179_30992433	0.19	SVILP1	supervillin pseudogene 1	7456	0.27
chr12_46364802_46364953	0.19	SCAF11	SR-related CTD-associated factor 11	19471	0.26
chr14_97586844_97587256	0.19	VRK1	vaccinia related kinase 1	244684	0.02
chr16_79732631_79732782	0.19	ENSG00000221330	.	29072	0.25
chr8_121760612_121760811	0.19	RP11-713M15.1		12782	0.25
chr8_6149074_6149420	0.19	RP11-115C21.2		114816	0.06
chr20_50149309_50149534	0.19	NFATC2	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2	9837	0.28
chr13_94981476_94981627	0.19	ENSG00000212057	.	136093	0.05
chr1_84630834_84631034	0.19	PRKACB	protein kinase, cAMP-dependent, catalytic, beta	285	0.94
chr3_136618635_136619053	0.19	NCK1	NCK adaptor protein 1	28037	0.15
chr1_198529109_198529554	0.19	ATP6V1G3	ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3	19256	0.26
chr4_113990983_113991134	0.19	RP11-650J17.1		2060	0.35
chr17_17084426_17084936	0.19	MPRIP	myosin phosphatase Rho interacting protein	1809	0.21
chr14_59696203_59696354	0.19	DAAM1	dishevelled associated activator of morphogenesis 1	33895	0.23
chr5_54332690_54332883	0.19	ENSG00000240535	.	2688	0.19
chr16_50352222_50352469	0.19	BRD7	bromodomain containing 7	1495	0.39
chr2_54439176_54439327	0.19	TSPYL6	TSPY-like 6	44158	0.15
chr5_297104_297351	0.19	AHRR	aryl-hydrocarbon receptor repressor	7064	0.16
chr8_33384467_33384618	0.19	ENSG00000252505	.	13016	0.13
chr9_112821797_112821948	0.19	AKAP2	A kinase (PRKA) anchor protein 2	10896	0.29
chr11_73722460_73722681	0.19	UCP3	uncoupling protein 3 (mitochondrial, proton carrier)	2090	0.27
chr6_125668081_125668232	0.18	RP11-735G4.1		27314	0.22
chr9_2043921_2044145	0.18	RP11-264I13.2		1990	0.4
chr12_9909080_9909231	0.18	CD69	CD69 molecule	4342	0.18
chr1_155818298_155818477	0.18	GON4L	gon-4-like (C. elegans)	8585	0.13
chr14_33232996_33233147	0.18	AKAP6	A kinase (PRKA) anchor protein 6	28014	0.26
chr2_54861555_54861706	0.18	AC093110.3		28299	0.18
chrX_129153057_129153208	0.18	BCORL1	BCL6 corepressor-like 1	4689	0.26
chr2_190274084_190274235	0.18	WDR75	WD repeat domain 75	32000	0.21
chr2_235245103_235245254	0.18	ARL4C	ADP-ribosylation factor-like 4C	160066	0.04
chr7_5728178_5728429	0.18	RNF216-IT1	RNF216 intronic transcript 1 (non-protein coding)	8211	0.21
chrX_109941851_109942119	0.18	CHRDL1	chordin-like 1	97008	0.09
chr15_40475765_40476212	0.18	BUB1B	BUB1 mitotic checkpoint serine/threonine kinase B	22720	0.12
chr1_93002263_93002481	0.18	GFI1	growth factor independent 1 transcription repressor	49939	0.16
chr14_22980436_22980633	0.18	TRAJ15	T cell receptor alpha joining 15	18046	0.09
chr17_36511040_36511191	0.18	SOCS7	suppressor of cytokine signaling 7	2289	0.25
chr1_9254308_9254459	0.18	H6PD	hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)	40451	0.12
chr1_245005708_245005859	0.18	COX20	COX20 cytochrome C oxidase assembly factor	6865	0.18
chr2_235369165_235369500	0.18	ARL4C	ADP-ribosylation factor-like 4C	35912	0.24
chr11_122928668_122928969	0.18	ENSG00000200879	.	51	0.91
chr1_240264155_240264306	0.18	FMN2	formin 2	9050	0.26
chr17_66289856_66290222	0.18	ARSG	arylsulfatase G	2380	0.24
chr1_96831244_96831395	0.18	ENSG00000200800	.	139862	0.05
chr5_39016639_39016790	0.18	RICTOR	RPTOR independent companion of MTOR, complex 2	57777	0.14
chr8_124038093_124038518	0.18	DERL1	derlin 1	293	0.88
chr3_111263688_111263954	0.18	CD96	CD96 molecule	2824	0.35
chr3_8485554_8485710	0.18	LMCD1-AS1	LMCD1 antisense RNA 1 (head to head)	57652	0.12
chr12_120123335_120123486	0.18	PRKAB1	protein kinase, AMP-activated, beta 1 non-catalytic subunit	13361	0.15
chr14_61975982_61976133	0.18	RP11-47I22.4		19789	0.19
chr7_43651193_43651460	0.18	STK17A	serine/threonine kinase 17a	28662	0.15
chr4_109002912_109003063	0.18	HADH	hydroxyacyl-CoA dehydrogenase	77196	0.09
chr17_66235194_66235719	0.18	AMZ2	archaelysin family metallopeptidase 2	8259	0.16
chr4_26016446_26016597	0.18	SMIM20	small integral membrane protein 20	100590	0.08
chr22_44453501_44453802	0.18	PARVB	parvin, beta	11290	0.25
chr3_16336322_16336681	0.18	RP11-415F23.2		19445	0.15
chr5_88054099_88054250	0.18	MEF2C	myocyte enhancer factor 2C	65431	0.11
chr6_157548074_157548363	0.18	ARID1B	AT rich interactive domain 1B (SWI1-like)	78173	0.11
chr1_52888786_52889059	0.18	ZCCHC11	zinc finger, CCHC domain containing 11	7831	0.14
chr16_53529096_53529247	0.18	AKTIP	AKT interacting protein	5070	0.22
chr9_73018662_73018829	0.18	KLF9	Kruppel-like factor 9	10795	0.27
chr3_45906834_45907101	0.18	CCR9	chemokine (C-C motif) receptor 9	21029	0.15
chr16_79305361_79305684	0.18	ENSG00000222244	.	7171	0.31
chr1_8181268_8181565	0.17	ENSG00000200975	.	85241	0.08
chr7_101034448_101034789	0.17	COL26A1	collagen, type XXVI, alpha 1	28496	0.16
chr1_26056713_26056889	0.17	MAN1C1	mannosidase, alpha, class 1C, member 1	20708	0.15
chr4_36312267_36312547	0.17	DTHD1	death domain containing 1	26763	0.2
chr2_36731284_36731435	0.17	CRIM1	cysteine rich transmembrane BMP regulator 1 (chordin-like)	9474	0.2
chr19_32842018_32842221	0.17	ZNF507	zinc finger protein 507	5494	0.19
chr22_27234053_27234204	0.17	ENSG00000200443	.	197722	0.03
chr14_68273154_68273305	0.17	ZFYVE26	zinc finger, FYVE domain containing 26	10075	0.16
chr9_88562258_88562525	0.17	NAA35	N(alpha)-acetyltransferase 35, NatC auxiliary subunit	5947	0.33
chr8_74006171_74006322	0.17	SBSPON	somatomedin B and thrombospondin, type 1 domain containing	739	0.64
chr8_22303264_22303495	0.17	PPP3CC	protein phosphatase 3, catalytic subunit, gamma isozyme	4501	0.18
chr2_233979932_233980083	0.17	INPP5D	inositol polyphosphate-5-phosphatase, 145kDa	54818	0.12
chr10_33444372_33444753	0.17	NRP1	neuropilin 1	30021	0.18
chr1_27658935_27659279	0.17	ENSG00000206888	.	7397	0.12
chr10_134235955_134236340	0.17	RP11-432J24.3		18841	0.16
chr6_24883877_24884217	0.17	FAM65B	family with sequence similarity 65, member B	6464	0.22
chr2_238316797_238316948	0.17	COL6A3	collagen, type VI, alpha 3	5919	0.22
chr1_182592317_182592642	0.17	RGS16	regulator of G-protein signaling 16	18936	0.19
chr5_34691745_34691896	0.17	RAI14	retinoic acid induced 14	4156	0.28
chr1_171477612_171477763	0.17	ENSG00000201126	.	11365	0.15
chr15_75082253_75083502	0.17	ENSG00000264386	.	1779	0.21
chr10_32638025_32638176	0.17	RP11-135A24.2		1775	0.21
chr8_86113087_86113275	0.17	E2F5	E2F transcription factor 5, p130-binding	5217	0.14
chr14_50421866_50422017	0.17	C14orf182	chromosome 14 open reading frame 182	52297	0.09
chr5_133422871_133423131	0.17	TCF7	transcription factor 7 (T-cell specific, HMG-box)	27401	0.19
chr21_45566716_45567470	0.17	C21orf33	chromosome 21 open reading frame 33	11092	0.14
chr5_14925553_14926121	0.17	ENSG00000212036	.	15088	0.25
chr11_130576966_130577117	0.17	C11orf44	chromosome 11 open reading frame 44	34190	0.23
chr16_3079776_3080084	0.17	RP11-473M20.5		2552	0.08
chr21_43843966_43844673	0.17	ENSG00000252619	.	6617	0.14
chr8_22316747_22317104	0.17	PPP3CC	protein phosphatase 3, catalytic subunit, gamma isozyme	16180	0.14

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of PAX6

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View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.7	GO:0033152	immunoglobulin V(D)J recombination(GO:0033152)
0.1	0.1	GO:0002326	B cell lineage commitment(GO:0002326)
0.1	0.3	GO:0007132	meiotic metaphase I(GO:0007132)
0.1	0.1	GO:0044413	evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.1	0.3	GO:0001911	negative regulation of leukocyte mediated cytotoxicity(GO:0001911)
0.1	0.3	GO:0030854	positive regulation of granulocyte differentiation(GO:0030854)
0.1	0.5	GO:0006198	cAMP catabolic process(GO:0006198)
0.1	0.4	GO:0045066	regulatory T cell differentiation(GO:0045066)
0.1	0.2	GO:0050862	positive regulation of T cell receptor signaling pathway(GO:0050862)
0.1	0.2	GO:0001880	Mullerian duct regression(GO:0001880)
0.1	0.2	GO:0007343	egg activation(GO:0007343)
0.0	0.2	GO:0045898	regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0	0.1	GO:0045074	interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.0	0.1	GO:0045341	MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343)
0.0	0.2	GO:0032527	protein exit from endoplasmic reticulum(GO:0032527)
0.0	0.2	GO:0015705	iodide transport(GO:0015705)
0.0	0.1	GO:0035405	histone-threonine phosphorylation(GO:0035405)
0.0	0.2	GO:0006925	inflammatory cell apoptotic process(GO:0006925)
0.0	0.1	GO:0045627	positive regulation of T-helper 1 cell differentiation(GO:0045627)
0.0	0.1	GO:0045722	positive regulation of gluconeogenesis(GO:0045722)
0.0	0.3	GO:0002839	regulation of response to tumor cell(GO:0002834) positive regulation of response to tumor cell(GO:0002836) regulation of immune response to tumor cell(GO:0002837) positive regulation of immune response to tumor cell(GO:0002839)
0.0	0.1	GO:0046137	negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137)
0.0	0.1	GO:0030505	inorganic diphosphate transport(GO:0030505)
0.0	1.0	GO:0050690	regulation of defense response to virus by virus(GO:0050690)
0.0	0.1	GO:0018076	N-terminal peptidyl-lysine acetylation(GO:0018076)
0.0	0.3	GO:0030889	negative regulation of B cell proliferation(GO:0030889)
0.0	0.1	GO:0097709	connective tissue replacement involved in inflammatory response wound healing(GO:0002248) connective tissue replacement(GO:0097709)
0.0	0.1	GO:0009138	pyrimidine nucleoside diphosphate metabolic process(GO:0009138)
0.0	0.1	GO:0009221	pyrimidine deoxyribonucleotide biosynthetic process(GO:0009221)
0.0	0.1	GO:0002890	negative regulation of B cell mediated immunity(GO:0002713) negative regulation of immunoglobulin mediated immune response(GO:0002890)
0.0	0.1	GO:0006931	substrate-dependent cell migration, cell attachment to substrate(GO:0006931)
0.0	0.1	GO:0034063	stress granule assembly(GO:0034063)
0.0	0.1	GO:0031936	negative regulation of chromatin silencing(GO:0031936)
0.0	0.1	GO:0010837	regulation of keratinocyte proliferation(GO:0010837)
0.0	0.1	GO:0042989	sequestering of actin monomers(GO:0042989)
0.0	0.1	GO:0017182	peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.0	0.1	GO:0070050	neuron cellular homeostasis(GO:0070050)
0.0	0.2	GO:0002063	chondrocyte development(GO:0002063)
0.0	0.1	GO:0002689	negative regulation of leukocyte chemotaxis(GO:0002689)
0.0	0.1	GO:0015015	heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0	0.1	GO:0008049	male courtship behavior(GO:0008049)
0.0	0.2	GO:0051489	regulation of filopodium assembly(GO:0051489)
0.0	0.1	GO:0007023	post-chaperonin tubulin folding pathway(GO:0007023)
0.0	0.1	GO:0009048	dosage compensation by inactivation of X chromosome(GO:0009048)
0.0	0.1	GO:0060523	prostate epithelial cord elongation(GO:0060523)
0.0	0.1	GO:0033688	regulation of osteoblast proliferation(GO:0033688)
0.0	0.1	GO:0006975	DNA damage induced protein phosphorylation(GO:0006975)
0.0	0.1	GO:0050847	progesterone receptor signaling pathway(GO:0050847)
0.0	0.1	GO:0006642	triglyceride mobilization(GO:0006642)
0.0	0.1	GO:0060575	intestinal epithelial cell differentiation(GO:0060575)
0.0	0.1	GO:0019805	quinolinate biosynthetic process(GO:0019805)
0.0	0.1	GO:0032776	DNA methylation on cytosine(GO:0032776) C-5 methylation of cytosine(GO:0090116)
0.0	0.1	GO:0032212	positive regulation of telomere maintenance via telomerase(GO:0032212) positive regulation of telomere maintenance via telomere lengthening(GO:1904358)
0.0	0.0	GO:1901419	regulation of response to alcohol(GO:1901419)
0.0	0.0	GO:0048293	isotype switching to IgE isotypes(GO:0048289) regulation of isotype switching to IgE isotypes(GO:0048293)
0.0	0.0	GO:0006154	adenosine catabolic process(GO:0006154)
0.0	0.2	GO:0043368	positive T cell selection(GO:0043368)
0.0	0.0	GO:0060033	anatomical structure regression(GO:0060033)
0.0	0.0	GO:0032714	negative regulation of interleukin-5 production(GO:0032714)
0.0	0.1	GO:0051497	negative regulation of stress fiber assembly(GO:0051497)
0.0	0.1	GO:0019276	UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.0	0.1	GO:0060261	positive regulation of transcription initiation from RNA polymerase II promoter(GO:0060261) positive regulation of DNA-templated transcription, initiation(GO:2000144)
0.0	0.1	GO:0090231	regulation of spindle checkpoint(GO:0090231)
0.0	0.0	GO:0046642	negative regulation of alpha-beta T cell proliferation(GO:0046642)
0.0	0.1	GO:0048714	positive regulation of oligodendrocyte differentiation(GO:0048714)
0.0	0.1	GO:1903054	regulation of extracellular matrix disassembly(GO:0010715) negative regulation of extracellular matrix disassembly(GO:0010716) regulation of extracellular matrix organization(GO:1903053) negative regulation of extracellular matrix organization(GO:1903054)
0.0	0.1	GO:0034616	response to laminar fluid shear stress(GO:0034616)
0.0	0.0	GO:0060435	bronchiole development(GO:0060435)
0.0	0.1	GO:0034392	negative regulation of smooth muscle cell apoptotic process(GO:0034392)
0.0	0.1	GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518) negative regulation of signal transduction by p53 class mediator(GO:1901797)
0.0	0.0	GO:0010882	regulation of cardiac muscle contraction by calcium ion signaling(GO:0010882)
0.0	0.0	GO:0015904	tetracycline transport(GO:0015904)
0.0	0.0	GO:0032071	regulation of endodeoxyribonuclease activity(GO:0032071)
0.0	0.1	GO:0032653	regulation of interleukin-10 production(GO:0032653) positive regulation of interleukin-10 production(GO:0032733)
0.0	0.1	GO:0021570	rhombomere 4 development(GO:0021570)
0.0	0.1	GO:0070208	protein heterotrimerization(GO:0070208)
0.0	0.1	GO:0001831	trophectodermal cellular morphogenesis(GO:0001831)
0.0	0.1	GO:0070779	D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0	0.1	GO:0009103	lipopolysaccharide biosynthetic process(GO:0009103)
0.0	0.1	GO:0070670	response to interleukin-4(GO:0070670)
0.0	0.1	GO:0042118	endothelial cell activation(GO:0042118)
0.0	0.0	GO:0060648	mammary gland bud morphogenesis(GO:0060648)
0.0	0.1	GO:0045349	interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354) positive regulation of interferon-alpha biosynthetic process(GO:0045356)
0.0	0.1	GO:0060287	epithelial cilium movement(GO:0003351) epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
0.0	0.1	GO:0060242	contact inhibition(GO:0060242)
0.0	0.1	GO:0021801	cerebral cortex radial glia guided migration(GO:0021801) telencephalon glial cell migration(GO:0022030)
0.0	0.0	GO:0045603	positive regulation of endothelial cell differentiation(GO:0045603)
0.0	0.0	GO:0045541	negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206)
0.0	0.0	GO:0060999	positive regulation of dendritic spine development(GO:0060999)
0.0	0.0	GO:0002032	desensitization of G-protein coupled receptor protein signaling pathway by arrestin(GO:0002032)
0.0	0.0	GO:0019532	oxalate transport(GO:0019532)
0.0	0.3	GO:0030838	positive regulation of actin filament polymerization(GO:0030838)
0.0	0.1	GO:0033169	histone H3-K9 demethylation(GO:0033169)
0.0	0.0	GO:2000758	positive regulation of histone acetylation(GO:0035066) positive regulation of protein acetylation(GO:1901985) positive regulation of peptidyl-lysine acetylation(GO:2000758)
0.0	0.1	GO:0045916	negative regulation of humoral immune response(GO:0002921) negative regulation of complement activation(GO:0045916) negative regulation of protein activation cascade(GO:2000258)
0.0	0.2	GO:0015701	bicarbonate transport(GO:0015701)
0.0	0.1	GO:0048311	mitochondrion distribution(GO:0048311)
0.0	0.0	GO:0043615	astrocyte cell migration(GO:0043615)
0.0	0.0	GO:0016080	synaptic vesicle targeting(GO:0016080)
0.0	0.1	GO:0043276	anoikis(GO:0043276)
0.0	0.0	GO:0045357	interferon-beta biosynthetic process(GO:0045350) regulation of interferon-beta biosynthetic process(GO:0045357) positive regulation of interferon-beta biosynthetic process(GO:0045359)
0.0	0.0	GO:0010831	positive regulation of myotube differentiation(GO:0010831)
0.0	0.1	GO:0006104	succinyl-CoA metabolic process(GO:0006104)
0.0	0.3	GO:0046677	response to antibiotic(GO:0046677)
0.0	0.0	GO:0060028	convergent extension involved in axis elongation(GO:0060028)
0.0	0.0	GO:0032351	negative regulation of hormone metabolic process(GO:0032351) negative regulation of hormone biosynthetic process(GO:0032353)
0.0	0.0	GO:0010459	negative regulation of heart rate(GO:0010459)
0.0	0.0	GO:0006772	thiamine metabolic process(GO:0006772)
0.0	0.0	GO:0002913	lymphocyte anergy(GO:0002249) regulation of T cell anergy(GO:0002667) positive regulation of T cell anergy(GO:0002669) T cell anergy(GO:0002870) regulation of lymphocyte anergy(GO:0002911) positive regulation of lymphocyte anergy(GO:0002913)
0.0	0.0	GO:0090084	negative regulation of inclusion body assembly(GO:0090084)
0.0	0.1	GO:0031000	response to caffeine(GO:0031000)
0.0	0.0	GO:0014012	peripheral nervous system axon regeneration(GO:0014012)
0.0	0.0	GO:0032506	cytokinetic process(GO:0032506)
0.0	0.0	GO:0034393	positive regulation of muscle cell apoptotic process(GO:0010661) positive regulation of smooth muscle cell apoptotic process(GO:0034393)
0.0	0.0	GO:0033160	positive regulation of protein import into nucleus, translocation(GO:0033160)
0.0	0.1	GO:0010739	positive regulation of protein kinase A signaling(GO:0010739)
0.0	0.0	GO:0045759	negative regulation of action potential(GO:0045759)
0.0	0.0	GO:0006290	pyrimidine dimer repair(GO:0006290)
0.0	0.0	GO:0021610	cranial nerve structural organization(GO:0021604) facial nerve morphogenesis(GO:0021610) facial nerve structural organization(GO:0021612)
0.0	0.0	GO:1901976	regulation of cell cycle checkpoint(GO:1901976)
0.0	0.0	GO:0030186	melatonin metabolic process(GO:0030186) melatonin biosynthetic process(GO:0030187)
0.0	0.0	GO:0006007	glucose catabolic process(GO:0006007)
0.0	0.0	GO:0045906	negative regulation of vasoconstriction(GO:0045906)
0.0	0.0	GO:0003402	planar cell polarity pathway involved in axis elongation(GO:0003402)
0.0	0.0	GO:0006344	maintenance of chromatin silencing(GO:0006344)
0.0	0.0	GO:0051708	intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) regulation by virus of viral protein levels in host cell(GO:0046719) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708)
0.0	0.0	GO:0050955	thermoception(GO:0050955)
0.0	0.0	GO:0043247	telomere capping(GO:0016233) protection from non-homologous end joining at telomere(GO:0031848) telomere maintenance in response to DNA damage(GO:0043247)
0.0	0.2	GO:0031114	regulation of microtubule depolymerization(GO:0031114)
0.0	0.3	GO:0050772	positive regulation of axonogenesis(GO:0050772)
0.0	0.0	GO:0009822	alkaloid catabolic process(GO:0009822)
0.0	0.1	GO:0040015	negative regulation of multicellular organism growth(GO:0040015)
0.0	0.1	GO:0051788	response to misfolded protein(GO:0051788)
0.0	0.0	GO:0046877	regulation of saliva secretion(GO:0046877)
0.0	0.1	GO:0016556	mRNA modification(GO:0016556)
0.0	0.2	GO:0016998	cell wall macromolecule catabolic process(GO:0016998)
0.0	0.3	GO:0006611	protein export from nucleus(GO:0006611)
0.0	0.2	GO:0032012	regulation of ARF protein signal transduction(GO:0032012)
0.0	0.0	GO:0045901	translational frameshifting(GO:0006452) positive regulation of translational elongation(GO:0045901) positive regulation of translational termination(GO:0045905)
0.0	0.0	GO:0006651	diacylglycerol biosynthetic process(GO:0006651)
0.0	0.0	GO:0009120	deoxyribonucleoside metabolic process(GO:0009120)
0.0	0.1	GO:0016264	gap junction assembly(GO:0016264)
0.0	0.0	GO:0035025	positive regulation of Rho protein signal transduction(GO:0035025)
0.0	0.0	GO:0034287	detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594)
0.0	0.0	GO:0002023	reduction of food intake in response to dietary excess(GO:0002023)
0.0	0.0	GO:0015816	glycine transport(GO:0015816)
0.0	0.0	GO:0014834	skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration(GO:0014834)
0.0	0.1	GO:0044409	entry into host cell(GO:0030260) entry into host(GO:0044409) entry into cell of other organism involved in symbiotic interaction(GO:0051806) entry into other organism involved in symbiotic interaction(GO:0051828)
0.0	0.0	GO:0010989	negative regulation of low-density lipoprotein particle clearance(GO:0010989)
0.0	0.0	GO:0051124	synaptic growth at neuromuscular junction(GO:0051124)
0.0	0.0	GO:0033194	response to hydroperoxide(GO:0033194)
0.0	0.0	GO:0007100	mitotic centrosome separation(GO:0007100)
0.0	0.0	GO:0021834	chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration(GO:0021834)
0.0	0.0	GO:0021797	forebrain anterior/posterior pattern specification(GO:0021797)
0.0	0.1	GO:0048251	elastic fiber assembly(GO:0048251)
0.0	0.1	GO:0070570	regulation of axon regeneration(GO:0048679) regulation of neuron projection regeneration(GO:0070570)
0.0	0.0	GO:0060676	ureteric bud formation(GO:0060676)
0.0	0.1	GO:0006658	phosphatidylserine metabolic process(GO:0006658)

Gene overrepresentation in cellular component category:

Total log-likelihood	Term	Description
0.1	GO:0005589	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.1	GO:0042105	alpha-beta T cell receptor complex(GO:0042105)
0.2	GO:0008290	F-actin capping protein complex(GO:0008290)
0.1	GO:0032045	guanyl-nucleotide exchange factor complex(GO:0032045)
0.2	GO:0042589	zymogen granule membrane(GO:0042589)
0.1	GO:0005896	interleukin-6 receptor complex(GO:0005896)
0.1	GO:0033270	paranode region of axon(GO:0033270)
0.2	GO:0005606	laminin-1 complex(GO:0005606)
0.1	GO:0032777	Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.1	GO:0031235	intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.3	GO:0010494	cytoplasmic stress granule(GO:0010494)
0.1	GO:0000300	obsolete peripheral to membrane of membrane fraction(GO:0000300)
0.2	GO:0042101	T cell receptor complex(GO:0042101)
0.1	GO:0034673	inhibin-betaglycan-ActRII complex(GO:0034673)
0.1	GO:0005697	telomerase holoenzyme complex(GO:0005697)
0.1	GO:0033011	perinuclear theca(GO:0033011)
0.1	GO:0000137	Golgi cis cisterna(GO:0000137)
0.1	GO:0032809	neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.1	GO:0005614	interstitial matrix(GO:0005614)
0.1	GO:0005587	collagen type IV trimer(GO:0005587)
0.4	GO:0031594	neuromuscular junction(GO:0031594)
0.0	GO:0072669	tRNA-splicing ligase complex(GO:0072669)
0.0	GO:0070852	cell body fiber(GO:0070852)
0.2	GO:0031105	septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.1	GO:0032839	dendrite cytoplasm(GO:0032839)
0.0	GO:0071438	invadopodium membrane(GO:0071438)
0.0	GO:0005863	striated muscle myosin thick filament(GO:0005863)
0.0	GO:0044215	host(GO:0018995) host cell part(GO:0033643) host intracellular part(GO:0033646) intracellular region of host(GO:0043656) host cell(GO:0043657) other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217)
0.2	GO:0033276	transcription factor TFTC complex(GO:0033276)
0.1	GO:0044224	juxtaparanode region of axon(GO:0044224)
0.1	GO:0016585	obsolete chromatin remodeling complex(GO:0016585)
0.1	GO:0005658	alpha DNA polymerase:primase complex(GO:0005658)
0.3	GO:0005626	obsolete insoluble fraction(GO:0005626)
0.0	GO:0072487	MSL complex(GO:0072487)
0.0	GO:0030934	anchoring collagen complex(GO:0030934)
0.0	GO:0060199	clathrin-sculpted glutamate transport vesicle(GO:0060199) clathrin-sculpted glutamate transport vesicle membrane(GO:0060203)
0.1	GO:0000153	cytoplasmic ubiquitin ligase complex(GO:0000153)
0.0	GO:0005954	calcium- and calmodulin-dependent protein kinase complex(GO:0005954)
0.1	GO:0017119	Golgi transport complex(GO:0017119)
0.1	GO:0005583	fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0001099	basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.1	0.2	GO:0030284	estrogen receptor activity(GO:0030284)
0.1	0.2	GO:0008510	sodium:bicarbonate symporter activity(GO:0008510)
0.1	0.2	GO:0051371	muscle alpha-actinin binding(GO:0051371)
0.1	0.1	GO:0019958	C-X-C chemokine binding(GO:0019958) interleukin-8 binding(GO:0019959)
0.0	0.2	GO:0005131	growth hormone receptor binding(GO:0005131)
0.0	0.1	GO:0045159	myosin II binding(GO:0045159)
0.0	0.1	GO:0008109	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0	0.1	GO:0008107	galactoside 2-alpha-L-fucosyltransferase activity(GO:0008107) alpha-(1,2)-fucosyltransferase activity(GO:0031127)
0.0	0.1	GO:0035184	histone threonine kinase activity(GO:0035184)
0.0	0.2	GO:0030618	transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0	0.1	GO:0003836	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0	0.2	GO:0015925	galactosidase activity(GO:0015925)
0.0	0.1	GO:0042978	ornithine decarboxylase activator activity(GO:0042978)
0.0	0.1	GO:0047756	chondroitin 4-sulfotransferase activity(GO:0047756)
0.0	0.1	GO:0016309	1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0	0.2	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.0	0.1	GO:0004924	oncostatin-M receptor activity(GO:0004924)
0.0	0.1	GO:0031628	opioid receptor binding(GO:0031628)
0.0	0.1	GO:0008179	adenylate cyclase binding(GO:0008179)
0.0	0.1	GO:0042289	MHC class II protein binding(GO:0042289)
0.0	0.4	GO:0004697	protein kinase C activity(GO:0004697)
0.0	0.2	GO:0016494	C-X-C chemokine receptor activity(GO:0016494)
0.0	0.2	GO:0030676	Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0	0.1	GO:0000293	ferric-chelate reductase activity(GO:0000293)
0.0	0.1	GO:0016842	amidine-lyase activity(GO:0016842)
0.0	0.1	GO:0070053	thrombospondin receptor activity(GO:0070053)
0.0	0.2	GO:0034593	phosphatidylinositol bisphosphate phosphatase activity(GO:0034593)
0.0	0.1	GO:0034452	dynactin binding(GO:0034452)
0.0	0.1	GO:0008454	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0	0.2	GO:0033613	activating transcription factor binding(GO:0033613)
0.0	0.5	GO:0008093	cytoskeletal adaptor activity(GO:0008093)
0.0	0.1	GO:0003886	DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0	0.0	GO:0004999	vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.0	0.1	GO:0003680	AT DNA binding(GO:0003680)
0.0	0.1	GO:0004949	cannabinoid receptor activity(GO:0004949)
0.0	0.0	GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.0	0.1	GO:0004677	DNA-dependent protein kinase activity(GO:0004677)
0.0	0.3	GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0	0.2	GO:0030332	cyclin binding(GO:0030332)
0.0	0.2	GO:0051018	protein kinase A binding(GO:0051018)
0.0	0.3	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0	0.5	GO:0045028	G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0	0.1	GO:0004706	JUN kinase kinase kinase activity(GO:0004706)
0.0	0.1	GO:0016941	natriuretic peptide receptor activity(GO:0016941)
0.0	0.1	GO:0030020	extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.0	0.1	GO:0005143	interleukin-12 receptor binding(GO:0005143)
0.0	0.2	GO:0005031	tumor necrosis factor-activated receptor activity(GO:0005031)
0.0	0.1	GO:0005350	pyrimidine nucleobase transmembrane transporter activity(GO:0005350)
0.0	0.1	GO:0070567	cytidylyltransferase activity(GO:0070567)
0.0	0.0	GO:0004142	diacylglycerol cholinephosphotransferase activity(GO:0004142)
0.0	0.1	GO:0060230	lipoprotein lipase activator activity(GO:0060230)
0.0	0.0	GO:0043398	HLH domain binding(GO:0043398)
0.0	0.1	GO:0043008	ATP-dependent protein binding(GO:0043008)
0.0	0.1	GO:0042285	UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285)
0.0	0.1	GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0	0.2	GO:0042288	MHC class I protein binding(GO:0042288)
0.0	0.1	GO:0004774	succinate-CoA ligase activity(GO:0004774)
0.0	0.1	GO:0005315	inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0	0.1	GO:0030274	LIM domain binding(GO:0030274)
0.0	0.1	GO:0008467	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0	0.1	GO:0004691	cAMP-dependent protein kinase activity(GO:0004691)
0.0	0.1	GO:0005522	profilin binding(GO:0005522)
0.0	0.0	GO:0043175	RNA polymerase core enzyme binding(GO:0043175)
0.0	0.0	GO:0042799	histone methyltransferase activity (H4-K20 specific)(GO:0042799)
0.0	0.2	GO:0004065	arylsulfatase activity(GO:0004065)
0.0	0.1	GO:0042043	neurexin family protein binding(GO:0042043)
0.0	0.1	GO:0000976	transcription regulatory region sequence-specific DNA binding(GO:0000976)
0.0	0.1	GO:0016721	superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.0	0.0	GO:0003953	NAD+ nucleosidase activity(GO:0003953)
0.0	0.1	GO:0047555	3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.0	0.0	GO:0030292	protein tyrosine kinase inhibitor activity(GO:0030292)
0.0	0.0	GO:0004566	beta-glucuronidase activity(GO:0004566)
0.0	0.1	GO:0050815	phosphoserine binding(GO:0050815)
0.0	0.0	GO:0004687	myosin light chain kinase activity(GO:0004687)
0.0	0.0	GO:0004311	farnesyltranstransferase activity(GO:0004311)
0.0	0.0	GO:0003909	DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.0	0.6	GO:0001948	glycoprotein binding(GO:0001948)
0.0	0.1	GO:0061659	ubiquitin-ubiquitin ligase activity(GO:0034450) ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659)
0.0	0.1	GO:0003988	acetyl-CoA C-acyltransferase activity(GO:0003988)
0.0	0.1	GO:0008195	phosphatidate phosphatase activity(GO:0008195)
0.0	0.1	GO:0004082	bisphosphoglycerate mutase activity(GO:0004082) bisphosphoglycerate 2-phosphatase activity(GO:0004083) phosphoglycerate mutase activity(GO:0004619)
0.0	0.2	GO:0015026	coreceptor activity(GO:0015026)
0.0	0.0	GO:0004748	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.0	0.0	GO:0032454	histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0	0.1	GO:0017154	semaphorin receptor activity(GO:0017154)
0.0	0.0	GO:0001085	RNA polymerase II transcription factor binding(GO:0001085)
0.0	0.1	GO:0008253	5'-nucleotidase activity(GO:0008253)
0.0	0.1	GO:0055103	ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106)
0.0	0.0	GO:0045545	syndecan binding(GO:0045545)
0.0	0.1	GO:0043425	bHLH transcription factor binding(GO:0043425)
0.0	0.1	GO:0001619	obsolete lysosphingolipid and lysophosphatidic acid receptor activity(GO:0001619)
0.0	0.1	GO:0048018	receptor agonist activity(GO:0048018)
0.0	0.1	GO:0030515	snoRNA binding(GO:0030515)
0.0	0.7	GO:0008301	DNA binding, bending(GO:0008301)
0.0	0.1	GO:0048407	platelet-derived growth factor binding(GO:0048407)
0.0	0.0	GO:0003726	double-stranded RNA adenosine deaminase activity(GO:0003726)
0.0	0.1	GO:0004024	alcohol dehydrogenase activity, zinc-dependent(GO:0004024)
0.0	0.1	GO:0005314	high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.0	0.1	GO:0004563	beta-N-acetylhexosaminidase activity(GO:0004563)
0.0	0.1	GO:0016986	obsolete transcription initiation factor activity(GO:0016986)
0.0	0.1	GO:0030507	spectrin binding(GO:0030507)
0.0	0.0	GO:0004738	pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.0	0.1	GO:0051019	mitogen-activated protein kinase binding(GO:0051019)
0.0	0.0	GO:0005134	interleukin-2 receptor binding(GO:0005134)
0.0	0.0	GO:0042608	T cell receptor binding(GO:0042608)
0.0	0.0	GO:0000404	heteroduplex DNA loop binding(GO:0000404)
0.0	0.2	GO:0001637	G-protein coupled chemoattractant receptor activity(GO:0001637) chemokine receptor activity(GO:0004950)
0.0	0.0	GO:0016882	cyclo-ligase activity(GO:0016882)
0.0	0.0	GO:0003896	DNA primase activity(GO:0003896)
0.0	0.0	GO:0042392	sphingosine-1-phosphate phosphatase activity(GO:0042392)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
1.2	PID REELIN PATHWAY	Reelin signaling pathway
0.0	PID CXCR3 PATHWAY	CXCR3-mediated signaling events
0.0	ST TUMOR NECROSIS FACTOR PATHWAY	Tumor Necrosis Factor Pathway.
0.0	PID S1P S1P1 PATHWAY	S1P1 pathway
0.1	PID IL2 1PATHWAY	IL2-mediated signaling events
0.2	ST TYPE I INTERFERON PATHWAY	Type I Interferon (alpha/beta IFN) Pathway
0.6	PID CDC42 REG PATHWAY	Regulation of CDC42 activity
0.8	PID CD8 TCR PATHWAY	TCR signaling in naïve CD8+ T cells
0.2	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.2	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
0.0	PID INTEGRIN A4B1 PATHWAY	Alpha4 beta1 integrin signaling events
0.3	PID RAC1 REG PATHWAY	Regulation of RAC1 activity
0.2	PID INTEGRIN3 PATHWAY	Beta3 integrin cell surface interactions
0.5	NABA BASEMENT MEMBRANES	Genes encoding structural components of basement membranes
0.2	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0	PID TCPTP PATHWAY	Signaling events mediated by TCPTP
0.0	PID ANTHRAX PATHWAY	Cellular roles of Anthrax toxin
0.3	PID RHOA REG PATHWAY	Regulation of RhoA activity

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.8	REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN	Genes involved in Platelet Adhesion to exposed collagen
0.0	0.0	REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1	Genes involved in Autodegradation of the E3 ubiquitin ligase COP1
0.0	0.1	REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION	Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0	0.1	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.0	0.6	REACTOME EFFECTS OF PIP2 HYDROLYSIS	Genes involved in Effects of PIP2 hydrolysis
0.0	0.3	REACTOME KERATAN SULFATE DEGRADATION	Genes involved in Keratan sulfate degradation
0.0	0.2	REACTOME IL 6 SIGNALING	Genes involved in Interleukin-6 signaling
0.0	0.0	REACTOME CDT1 ASSOCIATION WITH THE CDC6 ORC ORIGIN COMPLEX	Genes involved in CDT1 association with the CDC6:ORC:origin complex
0.0	0.3	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0	0.0	REACTOME SIGNALING BY EGFR IN CANCER	Genes involved in Signaling by EGFR in Cancer
0.0	0.2	REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0	0.2	REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP	Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0	0.2	REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE	Genes involved in Synthesis of PIPs at the early endosome membrane
0.0	0.2	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
0.0	0.2	REACTOME THE ACTIVATION OF ARYLSULFATASES	Genes involved in The activation of arylsulfatases
0.0	0.3	REACTOME NEF MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS	Genes involved in Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
0.0	0.1	REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS	Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.0	0.1	REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE	Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.0	0.1	REACTOME ACTIVATION OF RAC	Genes involved in Activation of Rac
0.0	0.1	REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING	Genes involved in Role of second messengers in netrin-1 signaling
0.0	0.2	REACTOME TCR SIGNALING	Genes involved in TCR signaling
0.0	0.1	REACTOME DSCAM INTERACTIONS	Genes involved in DSCAM interactions
0.0	0.0	REACTOME REGULATED PROTEOLYSIS OF P75NTR	Genes involved in Regulated proteolysis of p75NTR
0.0	0.1	REACTOME CTLA4 INHIBITORY SIGNALING	Genes involved in CTLA4 inhibitory signaling
0.0	0.1	REACTOME SYNTHESIS OF PE	Genes involved in Synthesis of PE