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ENCODE: H3K4me1 ChIP-Seq of primary human cells
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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for PAX8

Z-value: 1.75

Motif logo

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Transcription factors associated with PAX8

Gene Symbol Gene ID Gene Info
PAX8
ENSG00000125618.12 PAX8

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
PAX8chr2_114001694_11400184525090.210089-0.835.6e-03Click!
PAX8chr2_114034476_11403462714200.387427-0.835.7e-03Click!
PAX8chr2_114082072_114082267456420.115065-0.771.5e-02Click!
PAX8chr2_114028013_11402816478830.165803-0.761.7e-02Click!
PAX8chr2_114034842_11403501410430.499604-0.713.2e-02Click!

Activity of the PAX8 motif across conditions

Conditions sorted by the z-value of the PAX8 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr2_224329886_224330037 0.51 SCG2
 secretogranin II
 137041
 0.05
chr18_77265355_77265646 0.49 AC018445.1
 Uncharacterized protein
 10557
 0.27
chr22_30599698_30599849 0.41 RP3-438O4.4
3325
 0.18
chr15_68912808_68912959 0.40 CORO2B
 coronin, actin binding protein, 2B
 4004
 0.34
chr5_14918200_14918475 0.37 ENSG00000212036
 .
 7588
 0.26
chr5_126182403_126182766 0.36 LMNB1
 lamin B1
 69703
 0.11
chr5_158246848_158247336 0.35 CTD-2363C16.1
162922
 0.04
chr2_177353793_177353944 0.35 ENSG00000221304
 .
 105564
 0.06
chr4_77680501_77680652 0.34 RP11-359D14.2
949
 0.62
chr11_131627244_131627395 0.33 NTM
 neurotrimin
 96431
 0.08
chr11_116758675_116758826 0.33 SIK3-IT1
 SIK3 intronic transcript 1 (non-protein coding)
 2687
 0.21
chr14_69727423_69728222 0.33 GALNT16
 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 16
 814
 0.7
chr11_67796778_67797343 0.32 RP5-901A4.1
868
 0.34
chr10_64378374_64378669 0.32 ZNF365
 zinc finger protein 365
 25012
 0.22
chr4_78980109_78980524 0.32 FRAS1
 Fraser syndrome 1
 1592
 0.54
chr5_150002504_150002655 0.32 SYNPO
 synaptopodin
 5373
 0.17
chr17_77715532_77716324 0.32 ENPP7
 ectonucleotide pyrophosphatase/phosphodiesterase 7
 6588
 0.15
chr20_11759309_11759460 0.31 ENSG00000222281
 .
 40355
 0.21
chr1_157994884_157995035 0.31 KIRREL-IT1
 KIRREL intronic transcript 1 (non-protein coding)
 381
 0.89
chr17_37030037_37031006 0.31 LASP1
 LIM and SH3 protein 1
 378
 0.73
chr17_57502582_57502794 0.31 RP11-567L7.5
22024
 0.18
chr5_53810354_53810505 0.31 SNX18
 sorting nexin 18
 3160
 0.35
chr22_39712983_39713860 0.30 RPL3
 ribosomal protein L3
 1198
 0.26
chr17_1100600_1101315 0.30 ABR
 active BCR-related
 10341
 0.19
chr3_29183138_29183289 0.30 ENSG00000238470
 .
 130480
 0.05
chr12_53684080_53684231 0.30 PFDN5
 prefoldin subunit 5
 4920
 0.11
chr17_72508456_72508770 0.30 CD300LB
 CD300 molecule-like family member b
 18992
 0.13
chr4_48390789_48390940 0.29 SLAIN2
 SLAIN motif family, member 2
 5169
 0.28
chr6_169591237_169591388 0.29 XXyac-YX65C7_A.2
22037
 0.25
chr7_33759274_33759425 0.29 RP11-89N17.1
 HCG1643653; Uncharacterized protein
 6244
 0.26
chr6_127778672_127779081 0.28 KIAA0408
 KIAA0408
 1634
 0.47
chr2_225410237_225410483 0.28 CUL3
 cullin 3
 17656
 0.29
chr6_97629282_97629433 0.28 MMS22L
 MMS22-like, DNA repair protein
 81871
 0.11
chr15_75082253_75083502 0.28 ENSG00000264386
 .
 1779
 0.21
chr15_33121833_33121984 0.28 FMN1
 formin 1
 58547
 0.12
chr5_154078296_154078447 0.28 ENSG00000263478
 .
 4973
 0.17
chr1_25695888_25696039 0.27 ENSG00000238889
 .
 23095
 0.11
chr1_60460489_60460640 0.27 C1orf87
 chromosome 1 open reading frame 87
 13849
 0.22
chr3_17794774_17794953 0.27 TBC1D5
 TBC1 domain family, member 5
 10719
 0.3
chr1_235098252_235098681 0.27 ENSG00000239690
 .
 58533
 0.14
chr6_19845359_19845510 0.27 RP1-167F1.2
6123
 0.26
chr2_158345197_158345348 0.27 CYTIP
 cytohesin 1 interacting protein
 69
 0.98
chrX_117654909_117655177 0.27 DOCK11
 dedicator of cytokinesis 11
 25171
 0.21
chr22_30059316_30059467 0.27 RP1-76B20.12
56312
 0.08
chr7_90355373_90355524 0.27 CDK14
 cyclin-dependent kinase 14
 16272
 0.28
chr11_16201223_16201374 0.26 ENSG00000221556
 .
 55436
 0.17
chr3_112374400_112374551 0.26 CCDC80
 coiled-coil domain containing 80
 14328
 0.24
chr3_52683246_52683397 0.26 PBRM1
 polybromo 1
 29262
 0.08
chr1_56440025_56440176 0.26 PIGQP1
 phosphatidylinositol glycan anchor biosynthesis, class Q pseudogene 1
 35147
 0.24
chr3_132956077_132956228 0.26 RP11-402L6.1
19740
 0.23
chr14_30664962_30665113 0.26 PRKD1
 protein kinase D1
 3933
 0.37
chr15_50194108_50194259 0.26 ATP8B4
 ATPase, class I, type 8B, member 4
 6107
 0.24
chr2_168885204_168885426 0.26 AC016723.4
87661
 0.1
chr5_55981642_55982013 0.26 AC022431.2
 Homo sapiens uncharacterized LOC101928448 (LOC101928448), mRNA.
 79768
 0.09
chr1_240399314_240399591 0.26 FMN2
 formin 2
 9108
 0.25
chr10_634354_634505 0.25 DIP2C
 DIP2 disco-interacting protein 2 homolog C (Drosophila)
 4529
 0.22
chr6_134544887_134545038 0.25 ENSG00000238631
 .
 17310
 0.18
chr7_33290779_33290930 0.25 ENSG00000222741
 .
 73502
 0.1
chr3_128316611_128316762 0.25 C3orf27
 chromosome 3 open reading frame 27
 21757
 0.18
chr1_40310608_40311589 0.25 ENSG00000202222
 .
 36252
 0.1
chr6_148843708_148843859 0.25 ENSG00000223322
 .
 1593
 0.55
chrX_77173850_77174555 0.25 ATP7A
 ATPase, Cu++ transporting, alpha polypeptide
 8003
 0.16
chr10_17551314_17551651 0.25 ST8SIA6
 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6
 55153
 0.12
chr1_229165364_229165635 0.25 RP5-1061H20.5
197810
 0.02
chr8_106290655_106290818 0.25 ZFPM2
 zinc finger protein, FOG family member 2
 40184
 0.21
chr9_18906351_18906502 0.25 ENSG00000223211
 .
 71501
 0.09
chr5_102925029_102925180 0.24 NUDT12
 nudix (nucleoside diphosphate linked moiety X)-type motif 12
 26610
 0.27
chr8_108512063_108512336 0.24 ANGPT1
 angiopoietin 1
 1916
 0.51
chr1_112019762_112020149 0.24 C1orf162
 chromosome 1 open reading frame 162
 3464
 0.13
chr13_98742061_98742212 0.24 FARP1
 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
 52680
 0.14
chr8_134125209_134125360 0.24 TG
 thyroglobulin
 463
 0.84
chr2_175476241_175476664 0.24 WIPF1
 WAS/WASL interacting protein family, member 1
 13513
 0.19
chr12_1689048_1689199 0.24 WNT5B
 wingless-type MMTV integration site family, member 5B
 5300
 0.23
chr1_156772000_156772151 0.24 NTRK1
 neurotrophic tyrosine kinase, receptor, type 1
 13373
 0.11
chr15_70451790_70452201 0.24 ENSG00000200216
 .
 33580
 0.2
chr15_63322461_63322906 0.24 TPM1
 tropomyosin 1 (alpha)
 12148
 0.18
chr6_150020862_150021104 0.24 LATS1
 large tumor suppressor kinase 1
 2507
 0.23
chr10_60517984_60518135 0.24 BICC1
 bicaudal C homolog 1 (Drosophila)
 35236
 0.23
chr13_36604941_36605092 0.24 DCLK1
 doublecortin-like kinase 1
 100427
 0.08
chr12_93649910_93650061 0.24 ENSG00000238361
 .
 9523
 0.18
chr22_36828593_36829238 0.23 ENSG00000252575
 .
 6056
 0.16
chr1_112250360_112250551 0.23 FAM212B
 family with sequence similarity 212, member B
 31420
 0.13
chr5_142697140_142697291 0.23 NR3C1
 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
 83202
 0.1
chr13_76362925_76363076 0.23 LMO7
 LIM domain 7
 26
 0.99
chr9_21681553_21681704 0.23 ENSG00000244230
 .
 17685
 0.22
chr10_17694785_17694982 0.23 STAM
 signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
 8619
 0.15
chr3_171799802_171800095 0.23 FNDC3B
 fibronectin type III domain containing 3B
 35245
 0.21
chr2_217351437_217351650 0.23 AC098820.4
376
 0.83
chr20_42213255_42213406 0.23 IFT52
 intraflagellar transport 52 homolog (Chlamydomonas)
 6241
 0.18
chr3_16379745_16380065 0.23 RP11-415F23.3
910
 0.56
chr3_72059056_72059299 0.23 ENSG00000239250
 .
 182849
 0.03
chr8_68244076_68244285 0.23 ARFGEF1
 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)
 11732
 0.29
chr9_81800231_81800528 0.23 TLE4
 transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
 386309
 0.01
chr13_76231506_76231657 0.23 LMO7
 LIM domain 7
 21122
 0.17
chr6_8881710_8881861 0.23 SLC35B3
 solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B3
 445991
 0.01
chr17_48104312_48105191 0.23 ITGA3
 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
 28588
 0.11
chr11_122542292_122542848 0.23 UBASH3B
 ubiquitin associated and SH3 domain containing B
 16187
 0.23
chr1_25687138_25687289 0.23 ENSG00000238889
 .
 14345
 0.12
chr12_105252723_105252874 0.23 ENSG00000222579
 .
 7196
 0.26
chr6_112366386_112366743 0.23 WISP3
 WNT1 inducible signaling pathway protein 3
 8711
 0.21
chr15_101558619_101558838 0.23 RP11-505E24.3
30933
 0.18
chr8_38559260_38559411 0.22 TACC1
 transforming, acidic coiled-coil containing protein 1
 26369
 0.18
chr1_198290152_198290452 0.22 NEK7
 NIMA-related kinase 7
 100373
 0.08
chr22_20904853_20905469 0.22 MED15
 mediator complex subunit 15
 113
 0.95
chr15_48720845_48720996 0.22 DUT
 deoxyuridine triphosphatase
 96317
 0.07
chr4_119902260_119902411 0.22 SYNPO2
 synaptopodin 2
 42291
 0.19
chr19_44247433_44247584 0.22 SMG9
 SMG9 nonsense mediated mRNA decay factor
 11242
 0.12
chr10_120873283_120874145 0.22 FAM45A
 family with sequence similarity 45, member A
 10085
 0.14
chr20_52576656_52576839 0.22 AC005220.3
20048
 0.22
chr11_10344931_10345082 0.22 AMPD3
 adenosine monophosphate deaminase 3
 5788
 0.17
chr1_54200847_54200998 0.22 GLIS1
 GLIS family zinc finger 1
 1045
 0.54
chr3_61620522_61620673 0.22 PTPRG
 protein tyrosine phosphatase, receptor type, G
 73012
 0.13
chr2_24485812_24485963 0.22 ENSG00000251805
 .
 10723
 0.16
chr1_92250161_92250312 0.22 ENSG00000239794
 .
 45395
 0.17
chr11_43945029_43945180 0.22 C11orf96
 chromosome 11 open reading frame 96
 1788
 0.25
chr2_43187744_43187982 0.22 ENSG00000207087
 .
 130769
 0.05
chr8_107289610_107289761 0.22 OXR1
 oxidation resistance 1
 7212
 0.33
chr12_66635871_66636173 0.22 ENSG00000266539
 .
 6620
 0.17
chr11_84209939_84210090 0.22 DLG2
 discs, large homolog 2 (Drosophila)
 181632
 0.03
chr17_79542900_79543051 0.22 ENSG00000207021
 .
 2459
 0.15
chr15_71057979_71058253 0.22 UACA
 uveal autoantigen with coiled-coil domains and ankyrin repeats
 2184
 0.33
chr6_106196664_106197000 0.22 ENSG00000200198
 .
 155416
 0.04
chr2_229478365_229478516 0.22 ENSG00000251801
 .
 25851
 0.28
chr7_137341728_137341879 0.22 DGKI
 diacylglycerol kinase, iota
 189479
 0.03
chr13_27592725_27592876 0.22 USP12-AS1
 USP12 antisense RNA 1
 144192
 0.04
chr17_10030835_10031371 0.22 GAS7
 growth arrest-specific 7
 13233
 0.19
chr2_40351479_40351630 0.22 SLC8A1-AS1
 SLC8A1 antisense RNA 1
 9385
 0.32
chr3_151095588_151095739 0.22 P2RY12
 purinergic receptor P2Y, G-protein coupled, 12
 6937
 0.21
chr2_201483526_201483768 0.22 AOX1
 aldehyde oxidase 1
 30750
 0.18
chr22_36748127_36749442 0.22 MYH9
 myosin, heavy chain 9, non-muscle
 12372
 0.18
chr4_123582192_123582343 0.22 IL21
 interleukin 21
 40043
 0.15
chr11_74811459_74811610 0.21 SLCO2B1
 solute carrier organic anion transporter family, member 2B1
 102
 0.96
chr19_39148637_39148918 0.21 ACTN4
 actinin, alpha 4
 10399
 0.12
chr11_102307174_102307701 0.21 TMEM123
 transmembrane protein 123
 12746
 0.16
chr20_3257209_3257360 0.21 ENSG00000266792
 .
 3781
 0.19
chr10_90656637_90657017 0.21 STAMBPL1
 STAM binding protein-like 1
 4005
 0.21
chr4_113990983_113991134 0.21 RP11-650J17.1
2060
 0.35
chr14_52771351_52771577 0.21 PTGER2
 prostaglandin E receptor 2 (subtype EP2), 53kDa
 9559
 0.25
chr7_41026584_41026854 0.21 AC005160.3
211562
 0.03
chr10_53138057_53138208 0.21 RP11-539E19.2
75806
 0.1
chr6_33738099_33738250 0.21 LEMD2
 LEM domain containing 2
 6747
 0.17
chr2_38428694_38428845 0.21 ENSG00000199603
 .
 54212
 0.14
chr1_35509703_35509854 0.21 ZMYM6
 zinc finger, MYM-type 6
 12209
 0.16
chr1_68048532_68048683 0.21 ENSG00000207504
 .
 41797
 0.16
chr22_37914494_37915327 0.21 CARD10
 caspase recruitment domain family, member 10
 337
 0.83
chr2_198734738_198734942 0.21 PLCL1
 phospholipase C-like 1
 59858
 0.13
chr4_48301676_48301827 0.21 TEC
 tec protein tyrosine kinase
 29870
 0.18
chr18_77264951_77265123 0.21 AC018445.1
 Uncharacterized protein
 11020
 0.27
chr8_126341232_126341383 0.21 RP11-550A5.2
22351
 0.22
chr9_130549061_130550158 0.21 CDK9
 cyclin-dependent kinase 9
 1281
 0.22
chr1_12484600_12484751 0.21 VPS13D
 vacuolar protein sorting 13 homolog D (S. cerevisiae)
 14751
 0.23
chr1_65936173_65936324 0.21 RP4-630A11.3
15841
 0.19
chr18_18722144_18722362 0.21 ENSG00000251886
 .
 21786
 0.2
chr11_16217394_16217545 0.21 ENSG00000221556
 .
 71607
 0.13
chr2_191070291_191070442 0.21 HIBCH
 3-hydroxyisobutyryl-CoA hydrolase
 408
 0.88
chr17_47900739_47901025 0.21 RP11-304F15.3
22390
 0.13
chr8_9374741_9374892 0.21 TNKS
 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
 38608
 0.17
chr1_109912632_109912783 0.21 SORT1
 sortilin 1
 23272
 0.14
chr8_23750523_23750674 0.21 STC1
 stanniocalcin 1
 38278
 0.18
chr22_20874098_20874710 0.21 MED15
 mediator complex subunit 15
 3526
 0.14
chr1_203562288_203562439 0.21 ATP2B4
 ATPase, Ca++ transporting, plasma membrane 4
 33326
 0.18
chr6_43462822_43463617 0.21 TJAP1
 tight junction associated protein 1 (peripheral)
 5897
 0.09
chr1_113070160_113070311 0.21 RP4-671G15.2
9172
 0.18
chr17_7492402_7492756 0.21 SOX15
 SRY (sex determining region Y)-box 15
 811
 0.27
chr6_39777071_39777222 0.21 DAAM2
 dishevelled associated activator of morphogenesis 2
 16352
 0.24
chr2_206557180_206557331 0.21 NRP2
 neuropilin 2
 9240
 0.28
chr11_111806250_111806401 0.21 DIXDC1
 DIX domain containing 1
 1602
 0.23
chr15_34153076_34153227 0.20 RP11-3D4.2
3875
 0.25
chr3_120192941_120193092 0.20 FSTL1
 follistatin-like 1
 22916
 0.23
chr5_39416035_39416186 0.20 DAB2
 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
 8860
 0.28
chr6_113917736_113917887 0.20 ENSG00000266650
 .
 6306
 0.29
chr20_50113921_50114555 0.20 ENSG00000266761
 .
 44724
 0.16
chr11_94307961_94308232 0.20 PIWIL4
 piwi-like RNA-mediated gene silencing 4
 7239
 0.2
chr16_55519371_55519522 0.20 MMP2
 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
 3128
 0.29
chr2_109788957_109789466 0.20 ENSG00000264934
 .
 31167
 0.2
chr6_119431765_119431916 0.20 FAM184A
 family with sequence similarity 184, member A
 31496
 0.18
chr6_128390946_128391097 0.20 PTPRK
 protein tyrosine phosphatase, receptor type, K
 5113
 0.29
chr9_79075654_79076239 0.20 GCNT1
 glucosaminyl (N-acetyl) transferase 1, core 2
 1800
 0.46
chr2_237423469_237423620 0.20 IQCA1
 IQ motif containing with AAA domain 1
 7359
 0.27
chr14_94859843_94860002 0.20 SERPINA1
 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
 2892
 0.25
chr19_51640303_51640721 0.20 SIGLEC7
 sialic acid binding Ig-like lectin 7
 5044
 0.1
chr5_140873219_140873370 0.20 PCDHGC5
 protocadherin gamma subfamily C, 5
 4486
 0.1
chr11_44037085_44037236 0.20 ACCSL
 1-aminocyclopropane-1-carboxylate synthase homolog (Arabidopsis)(non-functional)-like
 32371
 0.14
chr4_25114906_25115057 0.20 SEPSECS
 Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase
 47039
 0.14
chr13_36272958_36273109 0.20 NBEA
 neurobeachin
 105890
 0.08
chr18_20639570_20639721 0.20 ENSG00000223023
 .
 35086
 0.13
chr3_16006227_16006629 0.20 ENSG00000207815
 .
 91150
 0.08
chr10_60396345_60396496 0.20 BICC1
 bicaudal C homolog 1 (Drosophila)
 123520
 0.06
chr13_75748662_75748813 0.20 ENSG00000266534
 .
 34436
 0.21
chr6_129928555_129928706 0.20 ARHGAP18
 Rho GTPase activating protein 18
 102740
 0.07
chr15_37070363_37070514 0.20 C15orf41
 chromosome 15 open reading frame 41
 22292
 0.25
chr6_11561314_11561465 0.20 TMEM170B
 transmembrane protein 170B
 22878
 0.23
chr12_15874070_15874221 0.20 EPS8
 epidermal growth factor receptor pathway substrate 8
 7054
 0.27
chr5_148861219_148861370 0.20 CSNK1A1
 casein kinase 1, alpha 1
 31426
 0.13
chr4_113437546_113438608 0.20 NEUROG2
 neurogenin 2
 749
 0.58
chr7_14873178_14873329 0.20 DGKB
 diacylglycerol kinase, beta 90kDa
 7719
 0.24
chr6_107979051_107979415 0.20 SCML4
 sex comb on midleg-like 4 (Drosophila)
 74366
 0.11
chr22_39828056_39828207 0.20 MGAT3
 mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
 25218
 0.12
chr12_91448286_91448437 0.20 KERA
 keratocan
 3399
 0.29
chr20_57092198_57092349 0.20 APCDD1L
 adenomatosis polyposis coli down-regulated 1-like
 2086
 0.39

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

StringDB image

First level regulatory network of PAX8

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0007132 meiotic metaphase I(GO:0007132)
0.1 0.3 GO:0071436 sodium ion export(GO:0071436)
0.1 0.3 GO:0071694 sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.1 0.2 GO:2000095 regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000095)
0.1 0.3 GO:0030210 heparin biosynthetic process(GO:0030210)
0.1 0.2 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.1 0.2 GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.1 0.3 GO:0033152 immunoglobulin V(D)J recombination(GO:0033152)
0.1 0.2 GO:0032509 endosome transport via multivesicular body sorting pathway(GO:0032509)
0.1 0.3 GO:0051497 negative regulation of stress fiber assembly(GO:0051497)
0.1 0.3 GO:0097061 dendritic spine morphogenesis(GO:0060997) regulation of dendritic spine morphogenesis(GO:0061001) dendritic spine organization(GO:0097061)
0.1 0.3 GO:0015705 iodide transport(GO:0015705)
0.1 0.4 GO:0070498 interleukin-1-mediated signaling pathway(GO:0070498)
0.1 0.2 GO:0060831 smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:0060831)
0.1 0.1 GO:0030505 inorganic diphosphate transport(GO:0030505)
0.1 0.2 GO:0070874 negative regulation of glycogen metabolic process(GO:0070874)
0.1 0.2 GO:0055098 response to low-density lipoprotein particle(GO:0055098)
0.1 0.2 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.1 0.2 GO:0060242 contact inhibition(GO:0060242)
0.1 0.2 GO:0043589 skin morphogenesis(GO:0043589)
0.1 0.2 GO:0048149 behavioral response to ethanol(GO:0048149)
0.1 0.1 GO:0042420 dopamine catabolic process(GO:0042420)
0.0 0.1 GO:0042996 regulation of Golgi to plasma membrane protein transport(GO:0042996)
0.0 0.1 GO:0048807 female genitalia morphogenesis(GO:0048807)
0.0 0.1 GO:0048861 leukemia inhibitory factor signaling pathway(GO:0048861)
0.0 0.3 GO:0060907 positive regulation of macrophage cytokine production(GO:0060907)
0.0 0.1 GO:0046121 deoxyribonucleoside catabolic process(GO:0046121)
0.0 0.2 GO:0090190 positive regulation of mesonephros development(GO:0061213) positive regulation of branching involved in ureteric bud morphogenesis(GO:0090190)
0.0 0.1 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 0.0 GO:0048845 venous blood vessel morphogenesis(GO:0048845)
0.0 0.2 GO:0046827 positive regulation of protein export from nucleus(GO:0046827)
0.0 0.1 GO:0001996 positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996)
0.0 0.1 GO:0045578 negative regulation of B cell differentiation(GO:0045578)
0.0 0.1 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.0 0.1 GO:0045627 positive regulation of T-helper 1 cell differentiation(GO:0045627)
0.0 0.1 GO:0060028 convergent extension involved in axis elongation(GO:0060028)
0.0 0.1 GO:0033860 regulation of NAD(P)H oxidase activity(GO:0033860)
0.0 0.2 GO:0045652 regulation of megakaryocyte differentiation(GO:0045652) regulation of hematopoietic progenitor cell differentiation(GO:1901532)
0.0 0.1 GO:0009158 purine nucleoside monophosphate catabolic process(GO:0009128) ribonucleoside monophosphate catabolic process(GO:0009158) purine ribonucleoside monophosphate catabolic process(GO:0009169)
0.0 0.1 GO:0010837 regulation of keratinocyte proliferation(GO:0010837)
0.0 0.3 GO:0048844 artery morphogenesis(GO:0048844)
0.0 0.2 GO:0001547 antral ovarian follicle growth(GO:0001547)
0.0 0.1 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
0.0 0.1 GO:0097531 mast cell chemotaxis(GO:0002551) regulation of mast cell chemotaxis(GO:0060753) positive regulation of mast cell chemotaxis(GO:0060754) mast cell migration(GO:0097531)
0.0 0.1 GO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.0 0.1 GO:0071502 cellular response to temperature stimulus(GO:0071502)
0.0 0.2 GO:0006048 UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.0 0.2 GO:0042090 interleukin-12 biosynthetic process(GO:0042090) regulation of interleukin-12 biosynthetic process(GO:0045075)
0.0 0.1 GO:0060083 smooth muscle contraction involved in micturition(GO:0060083)
0.0 0.1 GO:0010665 striated muscle cell apoptotic process(GO:0010658) cardiac muscle cell apoptotic process(GO:0010659) regulation of striated muscle cell apoptotic process(GO:0010662) negative regulation of striated muscle cell apoptotic process(GO:0010664) regulation of cardiac muscle cell apoptotic process(GO:0010665) negative regulation of cardiac muscle cell apoptotic process(GO:0010667)
0.0 0.1 GO:0016266 O-glycan processing(GO:0016266)
0.0 0.1 GO:0034616 response to laminar fluid shear stress(GO:0034616)
0.0 0.1 GO:0003323 type B pancreatic cell development(GO:0003323)
0.0 0.7 GO:0030199 collagen fibril organization(GO:0030199)
0.0 0.1 GO:0061042 vascular wound healing(GO:0061042) regulation of vascular wound healing(GO:0061043)
0.0 0.1 GO:0051014 actin filament severing(GO:0051014)
0.0 0.0 GO:0048702 embryonic neurocranium morphogenesis(GO:0048702)
0.0 0.1 GO:0030091 protein repair(GO:0030091)
0.0 0.1 GO:0090273 regulation of somatostatin secretion(GO:0090273)
0.0 0.1 GO:0090030 regulation of steroid hormone biosynthetic process(GO:0090030)
0.0 0.1 GO:0046952 ketone body catabolic process(GO:0046952)
0.0 0.2 GO:0070570 regulation of axon regeneration(GO:0048679) regulation of neuron projection regeneration(GO:0070570)
0.0 0.1 GO:0017121 phospholipid scrambling(GO:0017121)
0.0 0.0 GO:0034776 response to histamine(GO:0034776)
0.0 0.1 GO:0014874 response to stimulus involved in regulation of muscle adaptation(GO:0014874)
0.0 0.1 GO:0006654 phosphatidic acid biosynthetic process(GO:0006654)
0.0 0.1 GO:0006391 transcription initiation from mitochondrial promoter(GO:0006391)
0.0 0.1 GO:0051891 positive regulation of cardioblast differentiation(GO:0051891) positive regulation of cardiocyte differentiation(GO:1905209)
0.0 0.1 GO:0009048 dosage compensation by inactivation of X chromosome(GO:0009048)
0.0 0.0 GO:0045603 positive regulation of endothelial cell differentiation(GO:0045603)
0.0 0.1 GO:0070050 neuron cellular homeostasis(GO:0070050)
0.0 0.1 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.0 0.1 GO:0016322 neuron remodeling(GO:0016322)
0.0 0.1 GO:0048840 otolith development(GO:0048840)
0.0 0.1 GO:0070141 response to UV-A(GO:0070141)
0.0 0.0 GO:0097709 connective tissue replacement involved in inflammatory response wound healing(GO:0002248) connective tissue replacement(GO:0097709)
0.0 0.0 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.0 0.1 GO:0045905 translational frameshifting(GO:0006452) positive regulation of translational elongation(GO:0045901) positive regulation of translational termination(GO:0045905)
0.0 0.1 GO:0015840 urea transport(GO:0015840)
0.0 0.1 GO:0009051 pentose-phosphate shunt, oxidative branch(GO:0009051)
0.0 0.2 GO:0034446 substrate adhesion-dependent cell spreading(GO:0034446)
0.0 0.1 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0 0.1 GO:0009249 protein lipoylation(GO:0009249)
0.0 0.1 GO:0032506 cytokinetic process(GO:0032506)
0.0 0.0 GO:0042501 serine phosphorylation of STAT protein(GO:0042501)
0.0 0.0 GO:0045906 negative regulation of vasoconstriction(GO:0045906)
0.0 0.1 GO:0010842 retina layer formation(GO:0010842)
0.0 0.0 GO:0046826 negative regulation of protein export from nucleus(GO:0046826)
0.0 0.0 GO:0010757 negative regulation of plasminogen activation(GO:0010757)
0.0 0.1 GO:0006030 chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.0 0.1 GO:0008218 bioluminescence(GO:0008218)
0.0 0.1 GO:0002870 lymphocyte anergy(GO:0002249) regulation of T cell anergy(GO:0002667) positive regulation of T cell anergy(GO:0002669) T cell anergy(GO:0002870) regulation of lymphocyte anergy(GO:0002911) positive regulation of lymphocyte anergy(GO:0002913)
0.0 0.0 GO:0006210 pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) thymine metabolic process(GO:0019859)
0.0 0.0 GO:0061081 positive regulation of myeloid leukocyte cytokine production involved in immune response(GO:0061081)
0.0 0.1 GO:0003308 negative regulation of Wnt signaling pathway involved in heart development(GO:0003308)
0.0 0.0 GO:0045077 negative regulation of interferon-gamma biosynthetic process(GO:0045077)
0.0 0.0 GO:0070340 detection of bacterial lipoprotein(GO:0042494) detection of bacterial lipopeptide(GO:0070340)
0.0 0.1 GO:0060596 mammary placode formation(GO:0060596)
0.0 0.3 GO:0050832 defense response to fungus(GO:0050832)
0.0 0.1 GO:0006527 arginine catabolic process(GO:0006527)
0.0 0.0 GO:0060426 lung vasculature development(GO:0060426)
0.0 0.1 GO:0060398 regulation of growth hormone receptor signaling pathway(GO:0060398)
0.0 0.1 GO:0044253 positive regulation of collagen metabolic process(GO:0010714) positive regulation of collagen biosynthetic process(GO:0032967) positive regulation of multicellular organismal metabolic process(GO:0044253)
0.0 0.0 GO:0090085 regulation of protein deubiquitination(GO:0090085)
0.0 0.0 GO:0071072 regulation of phosphatidylinositol biosynthetic process(GO:0010511) regulation of phospholipid biosynthetic process(GO:0071071) negative regulation of phospholipid biosynthetic process(GO:0071072)
0.0 0.4 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.0 0.1 GO:0032964 collagen biosynthetic process(GO:0032964)
0.0 0.1 GO:0006434 seryl-tRNA aminoacylation(GO:0006434)
0.0 0.0 GO:0002072 optic cup morphogenesis involved in camera-type eye development(GO:0002072)
0.0 0.1 GO:0015871 choline transport(GO:0015871)
0.0 0.1 GO:0022027 interkinetic nuclear migration(GO:0022027)
0.0 0.0 GO:0046825 regulation of protein export from nucleus(GO:0046825)
0.0 0.1 GO:0006570 tyrosine metabolic process(GO:0006570)
0.0 0.0 GO:0051182 coenzyme transport(GO:0051182)
0.0 0.0 GO:0010834 obsolete telomere maintenance via telomere shortening(GO:0010834)
0.0 0.0 GO:0003079 obsolete positive regulation of natriuresis(GO:0003079)
0.0 0.0 GO:0010886 positive regulation of cholesterol storage(GO:0010886)
0.0 0.1 GO:0006896 Golgi to endosome transport(GO:0006895) Golgi to vacuole transport(GO:0006896)
0.0 0.0 GO:0007501 mesodermal cell fate specification(GO:0007501)
0.0 0.1 GO:0070528 protein kinase C signaling(GO:0070528)
0.0 0.1 GO:0060136 embryonic process involved in female pregnancy(GO:0060136)
0.0 0.1 GO:0045717 negative regulation of fatty acid biosynthetic process(GO:0045717)
0.0 0.0 GO:0051459 corticotropin secretion(GO:0051458) regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461)
0.0 0.1 GO:0031033 myosin filament organization(GO:0031033)
0.0 0.0 GO:0042726 flavin-containing compound metabolic process(GO:0042726)
0.0 0.1 GO:0042535 positive regulation of tumor necrosis factor biosynthetic process(GO:0042535)
0.0 0.2 GO:0045773 positive regulation of axon extension(GO:0045773)
0.0 0.1 GO:0043277 apoptotic cell clearance(GO:0043277)
0.0 0.0 GO:0060129 thyroid-stimulating hormone-secreting cell differentiation(GO:0060129)
0.0 0.1 GO:0071025 RNA surveillance(GO:0071025) nuclear RNA surveillance(GO:0071027) nuclear mRNA surveillance(GO:0071028)
0.0 0.2 GO:0030865 cortical cytoskeleton organization(GO:0030865)
0.0 0.2 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.0 0.0 GO:0030538 embryonic genitalia morphogenesis(GO:0030538)
0.0 0.0 GO:0032227 negative regulation of synaptic transmission, dopaminergic(GO:0032227)
0.0 0.0 GO:0010661 positive regulation of muscle cell apoptotic process(GO:0010661) positive regulation of smooth muscle cell apoptotic process(GO:0034393)
0.0 0.0 GO:0051451 myoblast migration(GO:0051451)
0.0 0.0 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.0 0.1 GO:0006678 glucosylceramide metabolic process(GO:0006678)
0.0 0.0 GO:0051124 synaptic growth at neuromuscular junction(GO:0051124)
0.0 0.1 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)
0.0 0.0 GO:2000644 regulation of low-density lipoprotein particle receptor catabolic process(GO:0032803) regulation of receptor catabolic process(GO:2000644)
0.0 0.1 GO:0000768 syncytium formation by plasma membrane fusion(GO:0000768)
0.0 0.1 GO:0006777 Mo-molybdopterin cofactor biosynthetic process(GO:0006777) Mo-molybdopterin cofactor metabolic process(GO:0019720) molybdopterin cofactor biosynthetic process(GO:0032324) molybdopterin cofactor metabolic process(GO:0043545) prosthetic group metabolic process(GO:0051189)
0.0 0.0 GO:0060291 long-term synaptic potentiation(GO:0060291)
0.0 0.1 GO:0006000 fructose metabolic process(GO:0006000)
0.0 0.0 GO:1902339 apoptotic process involved in mammary gland involution(GO:0060057) positive regulation of apoptotic process involved in mammary gland involution(GO:0060058) positive regulation of apoptotic process involved in morphogenesis(GO:1902339) regulation of mammary gland involution(GO:1903519) positive regulation of mammary gland involution(GO:1903521) positive regulation of apoptotic process involved in development(GO:1904747)
0.0 0.1 GO:0061004 pattern specification involved in kidney development(GO:0061004) renal system pattern specification(GO:0072048) pattern specification involved in metanephros development(GO:0072268)
0.0 0.0 GO:0043173 nucleotide salvage(GO:0043173)
0.0 0.1 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.0 0.1 GO:0032770 positive regulation of monooxygenase activity(GO:0032770)
0.0 0.2 GO:0044036 cell wall macromolecule metabolic process(GO:0044036) cell wall organization or biogenesis(GO:0071554)
0.0 0.0 GO:2000846 corticosteroid hormone secretion(GO:0035930) regulation of steroid hormone secretion(GO:2000831) regulation of corticosteroid hormone secretion(GO:2000846)
0.0 0.1 GO:0043268 positive regulation of potassium ion transport(GO:0043268)
0.0 0.0 GO:0090084 negative regulation of inclusion body assembly(GO:0090084)
0.0 0.0 GO:0000103 sulfate assimilation(GO:0000103)
0.0 0.1 GO:0009396 folic acid-containing compound biosynthetic process(GO:0009396)
0.0 0.0 GO:0070427 nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427)
0.0 0.0 GO:0007343 egg activation(GO:0007343)
0.0 0.0 GO:0007500 mesodermal cell fate determination(GO:0007500)
0.0 0.0 GO:0097576 vacuole fusion(GO:0097576)
0.0 0.1 GO:0035414 negative regulation of catenin import into nucleus(GO:0035414)
0.0 0.0 GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.0 0.2 GO:0051693 actin filament capping(GO:0051693)
0.0 0.0 GO:0001955 blood vessel maturation(GO:0001955)
0.0 0.1 GO:0042693 muscle cell fate commitment(GO:0042693)
0.0 0.1 GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518) negative regulation of signal transduction by p53 class mediator(GO:1901797)
0.0 0.0 GO:0045992 negative regulation of embryonic development(GO:0045992)
0.0 0.0 GO:0060457 negative regulation of digestive system process(GO:0060457)
0.0 0.0 GO:0034445 plasma lipoprotein particle oxidation(GO:0034441) regulation of lipoprotein oxidation(GO:0034442) negative regulation of lipoprotein oxidation(GO:0034443) regulation of plasma lipoprotein particle oxidation(GO:0034444) negative regulation of plasma lipoprotein particle oxidation(GO:0034445) lipoprotein modification(GO:0042160) lipoprotein oxidation(GO:0042161)
0.0 0.1 GO:0071320 cellular response to cAMP(GO:0071320)
0.0 0.0 GO:0048539 bone marrow development(GO:0048539)
0.0 0.0 GO:0007144 female meiosis I(GO:0007144)
0.0 0.1 GO:0051001 negative regulation of nitric-oxide synthase activity(GO:0051001)
0.0 0.1 GO:0006547 histidine metabolic process(GO:0006547)
0.0 0.0 GO:0046084 adenine salvage(GO:0006168) purine nucleobase salvage(GO:0043096) adenine metabolic process(GO:0046083) adenine biosynthetic process(GO:0046084)
0.0 0.0 GO:0005981 regulation of glycogen catabolic process(GO:0005981)
0.0 0.0 GO:0071043 CUT catabolic process(GO:0071034) CUT metabolic process(GO:0071043)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0098647 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.1 0.2 GO:0030934 anchoring collagen complex(GO:0030934)
0.0 0.2 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.0 0.2 GO:0033268 node of Ranvier(GO:0033268)
0.0 0.2 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.3 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.4 GO:0005583 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 0.4 GO:0030315 T-tubule(GO:0030315)
0.0 0.3 GO:0008290 F-actin capping protein complex(GO:0008290)
0.0 0.3 GO:0098651 basement membrane collagen trimer(GO:0098651)
0.0 0.3 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.1 GO:0005899 insulin receptor complex(GO:0005899)
0.0 0.2 GO:0005606 laminin-1 complex(GO:0005606)
0.0 0.1 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 0.1 GO:0001527 microfibril(GO:0001527)
0.0 0.1 GO:0005900 oncostatin-M receptor complex(GO:0005900)
0.0 0.2 GO:0008091 spectrin(GO:0008091)
0.0 0.2 GO:0045009 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.0 0.1 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.1 GO:0032449 CBM complex(GO:0032449)
0.0 0.1 GO:0000300 obsolete peripheral to membrane of membrane fraction(GO:0000300)
0.0 0.1 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.0 1.7 GO:0005925 focal adhesion(GO:0005925)
0.0 0.1 GO:0031512 motile primary cilium(GO:0031512)
0.0 0.0 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.0 0.1 GO:0036454 insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454)
0.0 0.0 GO:0043083 synaptic cleft(GO:0043083)
0.0 0.2 GO:0097517 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 0.0 GO:0005787 signal peptidase complex(GO:0005787)
0.0 0.0 GO:0000214 tRNA-intron endonuclease complex(GO:0000214)
0.0 0.1 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.0 0.2 GO:0045178 basal part of cell(GO:0045178)
0.0 0.5 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 0.1 GO:0010369 chromocenter(GO:0010369)
0.0 0.0 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.0 0.0 GO:0070852 cell body fiber(GO:0070852)
0.0 0.0 GO:0043656 host(GO:0018995) host cell part(GO:0033643) host intracellular part(GO:0033646) intracellular region of host(GO:0043656) host cell(GO:0043657) other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217)
0.0 0.0 GO:0042272 nuclear RNA export factor complex(GO:0042272)
0.0 0.2 GO:0005811 lipid particle(GO:0005811)
0.0 0.1 GO:0043020 NADPH oxidase complex(GO:0043020)
0.0 0.0 GO:0031904 endosome lumen(GO:0031904)
0.0 0.0 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.0 0.0 GO:0071942 XPC complex(GO:0071942)
0.0 0.0 GO:0005863 striated muscle myosin thick filament(GO:0005863)
0.0 0.0 GO:0030008 TRAPP complex(GO:0030008)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.1 0.2 GO:0001099 basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.1 0.3 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.1 0.3 GO:0005010 insulin-like growth factor-activated receptor activity(GO:0005010)
0.1 0.2 GO:0015204 urea transmembrane transporter activity(GO:0015204)
0.1 0.2 GO:0005030 neurotrophin receptor activity(GO:0005030)
0.1 0.2 GO:0004924 oncostatin-M receptor activity(GO:0004924)
0.1 0.2 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.1 0.2 GO:0004167 dopachrome isomerase activity(GO:0004167)
0.1 0.2 GO:0042285 UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285)
0.0 0.3 GO:0043274 phospholipase binding(GO:0043274)
0.0 0.1 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0 0.4 GO:0004955 prostaglandin receptor activity(GO:0004955)
0.0 0.3 GO:0070696 transmembrane receptor protein serine/threonine kinase binding(GO:0070696)
0.0 0.4 GO:0001968 fibronectin binding(GO:0001968)
0.0 0.2 GO:0051636 obsolete Gram-negative bacterial cell surface binding(GO:0051636)
0.0 0.1 GO:0003829 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0003829)
0.0 0.1 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.0 0.0 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0 0.1 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0 0.1 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 0.1 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0 0.4 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 0.1 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.0 0.1 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.0 1.2 GO:0005518 collagen binding(GO:0005518)
0.0 0.1 GO:0033130 acetylcholine receptor binding(GO:0033130)
0.0 0.2 GO:0030507 spectrin binding(GO:0030507)
0.0 0.1 GO:0004117 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117)
0.0 0.1 GO:0070097 delta-catenin binding(GO:0070097)
0.0 0.1 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.0 0.1 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.0 0.1 GO:0042808 obsolete neuronal Cdc2-like kinase binding(GO:0042808)
0.0 0.2 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0 0.4 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.3 GO:0005283 sodium:amino acid symporter activity(GO:0005283)
0.0 0.1 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.0 0.1 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0 0.2 GO:0030332 cyclin binding(GO:0030332)
0.0 0.1 GO:0004982 N-formyl peptide receptor activity(GO:0004982)
0.0 0.1 GO:0000268 peroxisome targeting sequence binding(GO:0000268)
0.0 0.5 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 0.2 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor(GO:0016653)
0.0 0.1 GO:0016623 oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor(GO:0016623)
0.0 0.2 GO:0005522 profilin binding(GO:0005522)
0.0 0.2 GO:0042171 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) lysophosphatidic acid acyltransferase activity(GO:0042171) lysophospholipid acyltransferase activity(GO:0071617)
0.0 0.1 GO:0017159 pantetheine hydrolase activity(GO:0017159)
0.0 0.1 GO:0047238 glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.0 0.1 GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.0 0.1 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.0 0.2 GO:0004551 nucleotide diphosphatase activity(GO:0004551)
0.0 0.1 GO:0004908 interleukin-1 receptor activity(GO:0004908)
0.0 0.1 GO:0042608 T cell receptor binding(GO:0042608)
0.0 0.1 GO:0016531 copper chaperone activity(GO:0016531)
0.0 0.1 GO:0003953 NAD+ nucleosidase activity(GO:0003953)
0.0 0.1 GO:0022821 potassium ion antiporter activity(GO:0022821)
0.0 0.1 GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.0 0.1 GO:0016635 oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor(GO:0016635)
0.0 0.1 GO:0004568 chitinase activity(GO:0004568)
0.0 0.1 GO:0008475 procollagen-lysine 5-dioxygenase activity(GO:0008475)
0.0 0.1 GO:0043495 protein anchor(GO:0043495)
0.0 0.1 GO:0008649 rRNA methyltransferase activity(GO:0008649)
0.0 0.2 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.0 0.1 GO:0015037 peptide disulfide oxidoreductase activity(GO:0015037)
0.0 0.3 GO:0005523 tropomyosin binding(GO:0005523)
0.0 0.1 GO:0004738 pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.0 0.1 GO:0004689 phosphorylase kinase activity(GO:0004689)
0.0 0.1 GO:0003910 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.0 0.1 GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184)
0.0 0.1 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.0 0.1 GO:0032296 ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296)
0.0 0.1 GO:0005110 frizzled-2 binding(GO:0005110)
0.0 0.1 GO:0034056 estrogen response element binding(GO:0034056)
0.0 0.1 GO:0004828 serine-tRNA ligase activity(GO:0004828)
0.0 0.0 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017)
0.0 0.1 GO:0004340 glucokinase activity(GO:0004340)
0.0 0.0 GO:0042978 ornithine decarboxylase activator activity(GO:0042978)
0.0 0.0 GO:0019834 phospholipase A2 inhibitor activity(GO:0019834)
0.0 0.1 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.0 0.1 GO:0009374 biotin binding(GO:0009374)
0.0 0.1 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.1 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.0 0.1 GO:0004470 malic enzyme activity(GO:0004470)
0.0 0.1 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.0 0.2 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641)
0.0 0.1 GO:0016901 oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor(GO:0016901)
0.0 0.1 GO:0000405 bubble DNA binding(GO:0000405)
0.0 0.1 GO:0005123 death receptor binding(GO:0005123)
0.0 0.1 GO:0005536 glucose binding(GO:0005536)
0.0 0.0 GO:0042289 MHC class II protein binding(GO:0042289)
0.0 0.1 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.0 0.1 GO:0019841 retinol binding(GO:0019841)
0.0 0.0 GO:0004792 thiosulfate sulfurtransferase activity(GO:0004792)
0.0 0.0 GO:0042156 obsolete zinc-mediated transcriptional activator activity(GO:0042156)
0.0 0.1 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 0.0 GO:0034584 piRNA binding(GO:0034584)
0.0 0.1 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.0 0.1 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.0 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.0 0.0 GO:0005350 pyrimidine nucleobase transmembrane transporter activity(GO:0005350)
0.0 0.0 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0 0.1 GO:0050815 phosphoserine binding(GO:0050815)
0.0 0.1 GO:0047429 nucleoside-triphosphate diphosphatase activity(GO:0047429)
0.0 0.0 GO:0070324 thyroid hormone binding(GO:0070324)
0.0 0.1 GO:0016679 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0 0.0 GO:0047023 androsterone dehydrogenase activity(GO:0047023)
0.0 0.1 GO:0016565 obsolete general transcriptional repressor activity(GO:0016565)
0.0 0.3 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.0 0.0 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.2 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 0.5 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 0.1 GO:0030274 LIM domain binding(GO:0030274)
0.0 0.0 GO:0015065 uridine nucleotide receptor activity(GO:0015065) G-protein coupled pyrimidinergic nucleotide receptor activity(GO:0071553)
0.0 0.1 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.0 0.1 GO:0031491 nucleosome binding(GO:0031491)
0.0 0.1 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 0.1 GO:0019864 IgG binding(GO:0019864)
0.0 0.1 GO:0015556 C4-dicarboxylate transmembrane transporter activity(GO:0015556)
0.0 0.0 GO:0008502 melatonin receptor activity(GO:0008502)
0.0 0.0 GO:0016886 ligase activity, forming phosphoric ester bonds(GO:0016886)
0.0 0.0 GO:0001758 retinal dehydrogenase activity(GO:0001758)
0.0 0.1 GO:0008199 ferric iron binding(GO:0008199)
0.0 0.0 GO:0004946 bombesin receptor activity(GO:0004946)
0.0 0.1 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.0 0.0 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0 0.0 GO:0017089 glycolipid transporter activity(GO:0017089)
0.0 0.1 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.0 0.2 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.1 GO:0005499 vitamin D binding(GO:0005499)
0.0 0.1 GO:0008171 O-methyltransferase activity(GO:0008171)
0.0 0.0 GO:0015226 amino-acid betaine transmembrane transporter activity(GO:0015199) carnitine transmembrane transporter activity(GO:0015226)
0.0 0.2 GO:0017147 Wnt-protein binding(GO:0017147)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.0 1.1 NABA COLLAGENS Genes encoding collagen proteins
0.0 0.4 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.0 0.1 PID IGF1 PATHWAY IGF1 pathway
0.0 0.1 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 0.1 PID LYSOPHOSPHOLIPID PATHWAY LPA receptor mediated events
0.0 0.0 PID EPO PATHWAY EPO signaling pathway
0.0 0.4 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.2 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.0 2.1 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 REACTOME ADP SIGNALLING THROUGH P2RY12 Genes involved in ADP signalling through P2Y purinoceptor 12
0.0 0.3 REACTOME PROSTANOID LIGAND RECEPTORS Genes involved in Prostanoid ligand receptors
0.0 0.0 REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 Genes involved in Autodegradation of the E3 ubiquitin ligase COP1
0.0 0.0 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.6 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.3 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.0 0.2 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.0 0.3 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 0.0 REACTOME PHOSPHOLIPASE C MEDIATED CASCADE Genes involved in Phospholipase C-mediated cascade
0.0 1.0 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.2 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.0 0.3 REACTOME KERATAN SULFATE KERATIN METABOLISM Genes involved in Keratan sulfate/keratin metabolism
0.0 0.2 REACTOME HYALURONAN METABOLISM Genes involved in Hyaluronan metabolism
0.0 0.2 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 0.0 REACTOME SIGNALING BY FGFR Genes involved in Signaling by FGFR
0.0 0.2 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 0.0 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.0 0.1 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.1 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.0 0.3 REACTOME AMINE COMPOUND SLC TRANSPORTERS Genes involved in Amine compound SLC transporters
0.0 0.0 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.0 0.0 REACTOME DOWNSTREAM TCR SIGNALING Genes involved in Downstream TCR signaling
0.0 0.0 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.0 REACTOME VIRAL MESSENGER RNA SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.0 0.0 REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL Genes involved in NF-kB is activated and signals survival
0.0 0.0 REACTOME ACYL CHAIN REMODELLING OF PI Genes involved in Acyl chain remodelling of PI
0.0 0.2 REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.0 0.2 REACTOME ENDOGENOUS STEROLS Genes involved in Endogenous sterols
0.0 0.0 REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA Genes involved in G beta:gamma signalling through PLC beta
0.0 0.1 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins