Project

ENCODE: H3K4me1 ChIP-Seq of primary human cells

Navigation

Downloads

CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for PBX2

Z-value: 1.11

Motif logo

Transcription factors associated with PBX2

Gene Symbol	Gene ID	Gene Info
PBX2 Ensembl NCBI GeneCards UniProt	ENSG00000204304.7	PBX2

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
PBX2	chr6_32156684_32156948	1147	0.244380	0.86	2.7e-03	Click!
PBX2	chr6_32155779_32155970	2089	0.129979	0.79	1.2e-02	Click!
PBX2	chr6_32156186_32156415	1663	0.162141	0.78	1.4e-02	Click!
PBX2	chr6_32158792_32159044	955	0.287118	0.66	5.4e-02	Click!
PBX2	chr6_32155397_32155696	2417	0.114804	0.53	1.4e-01	Click!

Activity of the PBX2 motif across conditions

Conditions sorted by the z-value of the PBX2 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr1_26696466_26696677	0.74	ZNF683	zinc finger protein 683	665	0.58
chr3_71451560_71451730	0.54	FOXP1	forkhead box P1	97734	0.08
chr7_50306943_50307629	0.53	IKZF1	IKAROS family zinc finger 1 (Ikaros)	37038	0.2
chr12_93827062_93827301	0.48	UBE2N	ubiquitin-conjugating enzyme E2N	7851	0.16
chr1_145396953_145397104	0.48	ENSG00000201558	.	14271	0.13
chr10_3915023_3915255	0.48	KLF6	Kruppel-like factor 6	87666	0.09
chr10_7554785_7554936	0.47	RP11-385N23.1		20309	0.21
chr13_95837972_95838123	0.47	ENSG00000238463	.	24551	0.24
chr2_158276348_158276584	0.46	CYTIP	cytohesin 1 interacting protein	19460	0.2
chr8_37127586_37127737	0.45	RP11-150O12.6		246878	0.02
chr14_78224263_78224414	0.44	C14orf178	chromosome 14 open reading frame 178	2835	0.18
chr11_48019132_48019288	0.44	PTPRJ	protein tyrosine phosphatase, receptor type, J	16931	0.19
chr5_7778754_7778905	0.43	RP11-711G10.1		28950	0.2
chr12_92423583_92424054	0.43	C12orf79	chromosome 12 open reading frame 79	106979	0.07
chr9_2154852_2155076	0.41	SMARCA2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	2716	0.31
chr2_204721588_204721739	0.41	CTLA4	cytotoxic T-lymphocyte-associated protein 4	10846	0.25
chr10_74051154_74051347	0.40	RP11-442H21.2		15512	0.15
chr8_20057388_20057552	0.40	ATP6V1B2	ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2	2520	0.27
chr17_40423553_40423822	0.39	AC003104.1		298	0.83
chr1_90223591_90223869	0.39	ENSG00000239176	.	10147	0.21
chr14_102306035_102306224	0.38	CTD-2017C7.1		261	0.91
chr15_55514570_55514956	0.38	RSL24D1	ribosomal L24 domain containing 1	25498	0.18
chr2_99084461_99084735	0.37	INPP4A	inositol polyphosphate-4-phosphatase, type I, 107kDa	23185	0.21
chr2_99378186_99378507	0.37	ENSG00000201070	.	20527	0.19
chr7_2739468_2739742	0.37	AMZ1	archaelysin family metallopeptidase 1	11769	0.21
chr17_76722732_76723209	0.37	CYTH1	cytohesin 1	1077	0.54
chr7_77433899_77434050	0.36	PHTF2	putative homeodomain transcription factor 2	5756	0.21
chr5_55152116_55152357	0.36	IL31RA	interleukin 31 receptor A	2878	0.28
chr9_100666794_100667000	0.36	C9orf156	chromosome 9 open reading frame 156	7856	0.16
chr12_65011200_65011351	0.35	ENSG00000207546	.	5014	0.14
chr2_204868825_204868976	0.35	ICOS	inducible T-cell co-stimulator	67397	0.13
chr3_153398482_153398633	0.35	ENSG00000200162	.	73391	0.11
chr15_64183841_64184299	0.35	ENSG00000199156	.	20852	0.19
chr16_57057139_57057438	0.35	NLRC5	NLR family, CARD domain containing 5	2311	0.23
chr3_20147752_20147943	0.34	ENSG00000266745	.	31210	0.16
chr6_24957255_24957453	0.34	FAM65B	family with sequence similarity 65, member B	21166	0.2
chrY_1649865_1650016	0.34	NA	NA	> 10⁶	NA
chr6_157183759_157183935	0.34	ARID1B	AT rich interactive domain 1B (SWI1-like)	38660	0.19
chrX_1699864_1700015	0.34	AKAP17A	A kinase (PRKA) anchor protein 17A	10547	0.21
chr4_40231477_40231628	0.34	RHOH	ras homolog family member H	29588	0.18
chr19_48761122_48761385	0.34	CARD8	caspase recruitment domain family, member 8	2050	0.19
chr20_21530099_21530250	0.34	NKX2-2	NK2 homeobox 2	35510	0.17
chr9_130544245_130544396	0.33	SH2D3C	SH2 domain containing 3C	3300	0.11
chr16_23877339_23877739	0.33	PRKCB	protein kinase C, beta	28995	0.21
chr7_50301242_50301499	0.33	IKZF1	IKAROS family zinc finger 1 (Ikaros)	42954	0.18
chr11_10479399_10479700	0.32	AMPD3	adenosine monophosphate deaminase 3	1816	0.36
chr12_40077357_40077585	0.32	C12orf40	chromosome 12 open reading frame 40	57486	0.13
chr7_37398412_37398702	0.32	ELMO1	engulfment and cell motility 1	5285	0.22
chr7_142426324_142426678	0.32	PRSS1	protease, serine, 1 (trypsin 1)	30818	0.16
chr8_27222846_27223110	0.32	PTK2B	protein tyrosine kinase 2 beta	15190	0.21
chr17_267560_267799	0.31	AC108004.3		3865	0.17
chr3_196396917_196397068	0.31	PIGX	phosphatidylinositol glycan anchor biosynthesis, class X	30346	0.1
chrX_1699314_1699465	0.31	AKAP17A	A kinase (PRKA) anchor protein 17A	11097	0.2
chr1_208049687_208049852	0.31	CD34	CD34 molecule	14068	0.26
chr7_38272993_38273191	0.31	STARD3NL	STARD3 N-terminal like	55095	0.17
chr11_60817313_60817464	0.31	CD6	CD6 molecule	41382	0.1
chr1_108330403_108330665	0.31	ENSG00000265536	.	11656	0.26
chr11_121329085_121329622	0.30	RP11-730K11.1		5631	0.26
chr5_156623615_156623766	0.30	ITK	IL2-inducible T-cell kinase	15853	0.12
chr1_101748824_101749089	0.30	RP4-575N6.5		40242	0.14
chr7_37349133_37349657	0.30	ELMO1	engulfment and cell motility 1	32972	0.18
chr17_76172343_76172703	0.30	SYNGR2	synaptogyrin 2	7284	0.11
chr1_40526792_40526943	0.30	CAP1	CAP, adenylate cyclase-associated protein 1 (yeast)	20313	0.16
chr18_52520228_52520804	0.30	RAB27B	RAB27B, member RAS oncogene family	25086	0.21
chr17_53147200_53147351	0.30	STXBP4	syntaxin binding protein 4	70098	0.12
chrY_1649313_1649464	0.29	NA	NA	> 10⁶	NA
chr22_47009198_47009548	0.29	GRAMD4	GRAM domain containing 4	6926	0.25
chr12_4059299_4059530	0.29	RP11-664D1.1		45028	0.18
chr10_7301219_7301413	0.29	SFMBT2	Scm-like with four mbt domains 2	149391	0.04
chr5_151335887_151336038	0.28	GLRA1	glycine receptor, alpha 1	31559	0.21
chr1_42271230_42271400	0.28	ENSG00000264896	.	46503	0.18
chr3_46142236_46142387	0.28	CCR3	chemokine (C-C motif) receptor 3	62785	0.1
chr5_55909103_55909387	0.28	AC022431.2	Homo sapiens uncharacterized LOC101928448 (LOC101928448), mRNA.	7186	0.27
chr6_144740266_144740510	0.28	UTRN	utrophin	75151	0.11
chr14_61884442_61884698	0.28	PRKCH	protein kinase C, eta	24706	0.21
chr11_2399386_2399879	0.28	ENSG00000238184	.	410	0.6
chr2_27255490_27255641	0.27	TMEM214	transmembrane protein 214	257	0.8
chr17_66343606_66343891	0.27	ARSG	arylsulfatase G	56089	0.1
chr7_77345751_77345902	0.27	RSBN1L	round spermatid basic protein 1-like	19358	0.23
chr1_31533317_31533468	0.27	PUM1	pumilio RNA-binding family member 1	1371	0.51
chr1_65342372_65342702	0.27	JAK1	Janus kinase 1	89650	0.08
chrX_70839652_70840082	0.27	CXCR3	chemokine (C-X-C motif) receptor 3	1500	0.39
chr5_118524120_118524302	0.27	ENSG00000264536	.	33879	0.15
chr12_92520593_92520744	0.27	C12orf79	chromosome 12 open reading frame 79	10129	0.18
chr7_36325933_36326467	0.27	EEPD1	endonuclease/exonuclease/phosphatase family domain containing 1	10553	0.18
chr3_59975455_59975606	0.26	NPCDR1	nasopharyngeal carcinoma, down-regulated 1	17947	0.31
chr19_18416810_18417169	0.26	LSM4	LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)	10080	0.09
chr13_51466339_51466600	0.26	RNASEH2B-AS1	RNASEH2B antisense RNA 1	691	0.7
chr1_93003931_93004098	0.26	GFI1	growth factor independent 1 transcription repressor	51581	0.15
chr2_38881811_38882051	0.26	GALM	galactose mutarotase (aldose 1-epimerase)	11121	0.17
chr9_92041929_92042366	0.26	SEMA4D	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D	8399	0.25
chr15_58812240_58812391	0.26	RP11-50C13.2		1195	0.47
chr2_143943517_143943668	0.26	RP11-190J23.1		13851	0.27
chr7_128581367_128581518	0.26	IRF5	interferon regulatory factor 5	716	0.63
chr1_9713515_9713810	0.26	C1orf200	chromosome 1 open reading frame 200	982	0.47
chr17_80359730_80359914	0.26	RP13-20L14.4		564	0.55
chr6_135339984_135340183	0.26	HBS1L	HBS1-like (S. cerevisiae)	8211	0.22
chr15_52975597_52975763	0.25	FAM214A	family with sequence similarity 214, member A	4111	0.27
chr14_61887636_61887875	0.25	PRKCH	protein kinase C, eta	21521	0.22
chr5_169074930_169075085	0.25	DOCK2	dedicator of cytokinesis 2	10756	0.25
chr14_31045998_31046149	0.25	G2E3	G2/M-phase specific E3 ubiquitin protein ligase	889	0.61
chr7_144474434_144474585	0.25	TPK1	thiamin pyrophosphokinase 1	38494	0.2
chr2_149633605_149633756	0.25	KIF5C	kinesin family member 5C	861	0.6
chr5_130728180_130728357	0.25	CDC42SE2	CDC42 small effector 2	6969	0.31
chr1_161035238_161035389	0.25	AL591806.1	Uncharacterized protein	342	0.73
chr1_154529530_154529831	0.25	UBE2Q1	ubiquitin-conjugating enzyme E2Q family member 1	1429	0.27
chr7_12770523_12770759	0.25	ENSG00000199470	.	30127	0.2
chr12_111018423_111018574	0.25	PPTC7	PTC7 protein phosphatase homolog (S. cerevisiae)	2627	0.23
chr6_36516425_36516576	0.25	STK38	serine/threonine kinase 38	1253	0.39
chr2_24552663_24552963	0.25	ITSN2	intersectin 2	30365	0.17
chr3_112274584_112274735	0.25	SLC35A5	solute carrier family 35, member A5	5897	0.2
chr5_70884636_70884801	0.25	MCCC2	methylcrotonoyl-CoA carboxylase 2 (beta)	1523	0.47
chr6_135409772_135409953	0.25	HBS1L	HBS1-like (S. cerevisiae)	14332	0.21
chr12_122986187_122986338	0.24	ZCCHC8	zinc finger, CCHC domain containing 8	744	0.61
chr8_61488613_61488764	0.24	RAB2A	RAB2A, member RAS oncogene family	8594	0.24
chr3_69331473_69331660	0.24	FRMD4B	FERM domain containing 4B	10646	0.29
chrX_44105289_44105582	0.24	EFHC2	EF-hand domain (C-terminal) containing 2	97483	0.08
chr3_48129253_48129632	0.24	MAP4	microtubule-associated protein 4	872	0.58
chr16_28306696_28306847	0.24	SBK1	SH3 domain binding kinase 1	2931	0.27
chr1_118159462_118159660	0.24	FAM46C	family with sequence similarity 46, member C	11005	0.21
chr6_36854300_36854600	0.24	C6orf89	chromosome 6 open reading frame 89	810	0.61
chr9_79038613_79038764	0.24	GCNT1	glucosaminyl (N-acetyl) transferase 1, core 2	3936	0.3
chr6_91003875_91004215	0.24	BACH2	BTB and CNC homology 1, basic leucine zipper transcription factor 2	2416	0.36
chr9_117129330_117129481	0.23	AKNA	AT-hook transcription factor	9839	0.2
chr2_9540803_9540954	0.23	ITGB1BP1	integrin beta 1 binding protein 1	19545	0.18
chr2_158305057_158305360	0.23	CYTIP	cytohesin 1 interacting protein	4554	0.25
chr3_105470829_105471066	0.23	CBLB	Cbl proto-oncogene B, E3 ubiquitin protein ligase	49902	0.2
chr9_78641008_78641159	0.23	PCSK5	proprotein convertase subtilisin/kexin type 5	69810	0.13
chr5_75687734_75687885	0.23	IQGAP2	IQ motif containing GTPase activating protein 2	11265	0.27
chr19_48748323_48748474	0.23	CARD8	caspase recruitment domain family, member 8	4078	0.14
chr14_99646768_99646919	0.23	AL162151.4		22090	0.23
chr13_51995049_51995200	0.23	INTS6	integrator complex subunit 6	386	0.83
chr12_21768112_21768692	0.23	GYS2	glycogen synthase 2 (liver)	10621	0.19
chr3_30663550_30663701	0.23	TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	15532	0.28
chr15_86104644_86104795	0.23	AKAP13	A kinase (PRKA) anchor protein 13	6042	0.2
chr1_167598592_167598792	0.23	RCSD1	RCSD domain containing 1	638	0.62
chr18_9082924_9083342	0.23	NDUFV2	NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa	19495	0.17
chr7_50461724_50462037	0.23	ENSG00000200815	.	41198	0.16
chr5_112714195_112714492	0.23	CTD-2201G3.1		54932	0.13
chr5_50006083_50006243	0.23	PARP8	poly (ADP-ribose) polymerase family, member 8	42772	0.22
chr13_28017259_28017410	0.22	MTIF3	mitochondrial translational initiation factor 3	6992	0.17
chr6_34361725_34361876	0.22	NUDT3	nudix (nucleoside diphosphate linked moiety X)-type motif 3	1349	0.42
chr2_160579118_160579420	0.22	MARCH7	membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase	10251	0.25
chr9_120588985_120589386	0.22	ENSG00000251847	.	95436	0.08
chr3_13388775_13388976	0.22	NUP210	nucleoporin 210kDa	72934	0.11
chr6_15278908_15279059	0.22	JARID2	jumonji, AT rich interactive domain 2	29840	0.15
chr7_116651601_116651894	0.22	ST7	suppression of tumorigenicity 7	3195	0.23
chr3_71094319_71094756	0.22	FOXP1	forkhead box P1	19540	0.28
chr9_20378989_20379416	0.22	MLLT3	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	3265	0.26
chr3_151981214_151981600	0.22	MBNL1	muscleblind-like splicing regulator 1	4422	0.25
chr20_57696300_57696451	0.22	ZNF831	zinc finger protein 831	69700	0.09
chr22_23164320_23164502	0.22	IGLV2-8	immunoglobulin lambda variable 2-8	742	0.25
chr12_8222666_8222831	0.22	C3AR1	complement component 3a receptor 1	3681	0.18
chr12_69068762_69069251	0.22	NUP107	nucleoporin 107kDa	11508	0.2
chr12_105158634_105158785	0.22	ENSG00000222579	.	86893	0.09
chr6_118003746_118003897	0.22	NUS1	nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae)	7156	0.29
chr13_75896952_75897103	0.22	TBC1D4	TBC1 domain family, member 4	18640	0.24
chr12_66704736_66704887	0.22	HELB	helicase (DNA) B	8486	0.17
chr4_40245605_40245832	0.22	RHOH	ras homolog family member H	43754	0.15
chr18_2573236_2573505	0.22	NDC80	NDC80 kinetochore complex component	1806	0.24
chr14_64340480_64340720	0.22	SYNE2	spectrin repeat containing, nuclear envelope 2	20868	0.2
chr10_8099455_8099947	0.22	GATA3	GATA binding protein 3	2932	0.41
chr6_25028483_25028634	0.22	ENSG00000244618	.	2952	0.25
chr8_127513116_127513267	0.22	ENSG00000207138	.	3817	0.28
chr10_15212173_15212438	0.21	NMT2	N-myristoyltransferase 2	1613	0.42
chr20_58712383_58712535	0.21	C20orf197	chromosome 20 open reading frame 197	81479	0.1
chr1_14058388_14058781	0.21	PRDM2	PR domain containing 2, with ZNF domain	17314	0.21
chr1_93653739_93653893	0.21	TMED5	transmembrane emp24 protein transport domain containing 5	7531	0.19
chr16_3623403_3623748	0.21	NLRC3	NLR family, CARD domain containing 3	3817	0.17
chr4_148972313_148972526	0.21	RP11-76G10.1		95203	0.09
chr17_47434205_47434356	0.21	ZNF652	zinc finger protein 652	5198	0.14
chr5_79476055_79476349	0.21	CTC-458I2.2		52018	0.12
chr3_186635155_186635311	0.21	ST6GAL1	ST6 beta-galactosamide alpha-2,6-sialyltranferase 1	13041	0.17
chr4_118787870_118788021	0.21	NDST3	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3	167555	0.04
chr14_100549474_100549745	0.21	CTD-2376I20.1		8394	0.14
chr20_45622950_45623101	0.21	EYA2	eyes absent homolog 2 (Drosophila)	4385	0.32
chr17_62965165_62965316	0.21	AMZ2P1	archaelysin family metallopeptidase 2 pseudogene 1	4395	0.17
chr2_197026509_197026798	0.21	STK17B	serine/threonine kinase 17b	5282	0.22
chr2_28996370_28996521	0.21	PPP1CB	protein phosphatase 1, catalytic subunit, beta isozyme	5421	0.19
chr3_111391150_111391301	0.21	PLCXD2	phosphatidylinositol-specific phospholipase C, X domain containing 2	2298	0.3
chr7_72705805_72706094	0.21	GTF2IRD2P1	GTF2I repeat domain containing 2 pseudogene 1	11806	0.13
chr14_91829300_91829451	0.21	ENSG00000265856	.	29318	0.18
chr7_96314992_96315143	0.21	SHFM1	split hand/foot malformation (ectrodactyly) type 1	24096	0.26
chr13_47225060_47225405	0.20	LRCH1	leucine-rich repeats and calponin homology (CH) domain containing 1	28739	0.24
chr16_9043089_9043275	0.20	USP7	ubiquitin specific peptidase 7 (herpes virus-associated)	7055	0.21
chr10_99895864_99896043	0.20	R3HCC1L	R3H domain and coiled-coil containing 1-like	1525	0.51
chr22_23134104_23134282	0.20	ENSG00000207833	.	784	0.23
chr10_22946008_22946242	0.20	PIP4K2A	phosphatidylinositol-5-phosphate 4-kinase, type II, alpha	56912	0.15
chr18_60822595_60822747	0.20	RP11-299P2.1		4118	0.28
chr20_37432775_37433181	0.20	PPP1R16B	protein phosphatase 1, regulatory subunit 16B	1370	0.43
chr6_144499684_144499835	0.20	STX11	syntaxin 11	28096	0.21
chr8_81052812_81053539	0.20	RP11-92K15.1		18088	0.19
chr7_129260518_129260719	0.20	NRF1	nuclear respiratory factor 1	9021	0.24
chr2_42327539_42327704	0.20	PKDCC	protein kinase domain containing, cytoplasmic	52461	0.13
chr9_100668728_100668903	0.20	C9orf156	chromosome 9 open reading frame 156	5938	0.17
chr18_21518242_21518494	0.20	LAMA3	laminin, alpha 3	7780	0.21
chr12_47781967_47782118	0.20	ENSG00000264906	.	23990	0.21
chr11_4111133_4111394	0.20	RRM1	ribonucleotide reductase M1	4776	0.22
chr6_135339335_135339622	0.20	HBS1L	HBS1-like (S. cerevisiae)	8816	0.22
chr13_42967027_42967422	0.20	AKAP11	A kinase (PRKA) anchor protein 11	120935	0.06

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of PBX2

View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0045589	regulation of regulatory T cell differentiation(GO:0045589)
0.1	0.3	GO:0033152	immunoglobulin V(D)J recombination(GO:0033152)
0.1	0.2	GO:0002664	T cell tolerance induction(GO:0002517) regulation of T cell tolerance induction(GO:0002664) positive regulation of T cell tolerance induction(GO:0002666)
0.1	0.2	GO:0035405	histone-threonine phosphorylation(GO:0035405)
0.1	0.5	GO:0006491	N-glycan processing(GO:0006491)
0.1	0.4	GO:0007172	signal complex assembly(GO:0007172)
0.1	0.2	GO:0030187	melatonin metabolic process(GO:0030186) melatonin biosynthetic process(GO:0030187)
0.1	0.2	GO:0007100	mitotic centrosome separation(GO:0007100)
0.1	0.1	GO:0032714	negative regulation of interleukin-5 production(GO:0032714)
0.0	0.1	GO:0001778	plasma membrane repair(GO:0001778)
0.0	0.1	GO:0031580	membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.0	0.1	GO:0046101	hypoxanthine biosynthetic process(GO:0046101)
0.0	0.1	GO:0043320	natural killer cell activation involved in immune response(GO:0002323) natural killer cell degranulation(GO:0043320)
0.0	0.2	GO:0007097	nuclear migration(GO:0007097)
0.0	0.1	GO:0045722	positive regulation of gluconeogenesis(GO:0045722)
0.0	0.1	GO:0006552	leucine catabolic process(GO:0006552)
0.0	0.1	GO:0006154	adenosine catabolic process(GO:0006154)
0.0	0.1	GO:0050862	positive regulation of T cell receptor signaling pathway(GO:0050862)
0.0	0.1	GO:0009448	gamma-aminobutyric acid metabolic process(GO:0009448)
0.0	0.1	GO:0006667	sphinganine metabolic process(GO:0006667)
0.0	0.1	GO:0060586	multicellular organismal iron ion homeostasis(GO:0060586)
0.0	0.1	GO:0050857	positive regulation of antigen receptor-mediated signaling pathway(GO:0050857)
0.0	0.1	GO:0046642	negative regulation of alpha-beta T cell proliferation(GO:0046642)
0.0	0.1	GO:0045341	MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343)
0.0	0.1	GO:0015959	diadenosine polyphosphate metabolic process(GO:0015959)
0.0	0.1	GO:0045603	positive regulation of endothelial cell differentiation(GO:0045603)
0.0	0.1	GO:0010216	maintenance of DNA methylation(GO:0010216)
0.0	0.3	GO:0050860	negative regulation of antigen receptor-mediated signaling pathway(GO:0050858) negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0	0.1	GO:0045292	mRNA cis splicing, via spliceosome(GO:0045292)
0.0	0.1	GO:0046015	carbon catabolite regulation of transcription(GO:0045990) regulation of transcription by glucose(GO:0046015)
0.0	0.1	GO:0006089	lactate metabolic process(GO:0006089)
0.0	0.1	GO:1901341	activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0	0.1	GO:0010956	negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137)
0.0	0.1	GO:0030854	positive regulation of granulocyte differentiation(GO:0030854)
0.0	0.1	GO:0071698	olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.0	0.1	GO:0009158	purine nucleoside monophosphate catabolic process(GO:0009128) ribonucleoside monophosphate catabolic process(GO:0009158) purine ribonucleoside monophosphate catabolic process(GO:0009169)
0.0	0.2	GO:0000132	establishment of mitotic spindle orientation(GO:0000132) establishment of spindle orientation(GO:0051294)
0.0	0.1	GO:0031061	negative regulation of histone methylation(GO:0031061)
0.0	0.1	GO:0000729	DNA double-strand break processing(GO:0000729)
0.0	0.1	GO:0006104	succinyl-CoA metabolic process(GO:0006104)
0.0	0.2	GO:2000144	positive regulation of transcription initiation from RNA polymerase II promoter(GO:0060261) positive regulation of DNA-templated transcription, initiation(GO:2000144)
0.0	0.3	GO:0043550	regulation of lipid kinase activity(GO:0043550)
0.0	0.3	GO:0030224	monocyte differentiation(GO:0030224)
0.0	0.2	GO:0006198	cAMP catabolic process(GO:0006198)
0.0	0.1	GO:0007207	phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.0	0.1	GO:0002430	complement receptor mediated signaling pathway(GO:0002430)
0.0	0.1	GO:0033632	regulation of cell-cell adhesion mediated by integrin(GO:0033632)
0.0	0.6	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.0	0.1	GO:0060296	regulation of cilium movement(GO:0003352) regulation of cilium beat frequency(GO:0003356) cilium movement involved in cell motility(GO:0060294) regulation of cilium movement involved in cell motility(GO:0060295) regulation of cilium beat frequency involved in ciliary motility(GO:0060296) regulation of cilium-dependent cell motility(GO:1902019)
0.0	0.1	GO:0061302	smooth muscle cell-matrix adhesion(GO:0061302)
0.0	0.1	GO:0032790	ribosome disassembly(GO:0032790)
0.0	0.1	GO:0048096	chromatin-mediated maintenance of transcription(GO:0048096)
0.0	0.1	GO:0032232	negative regulation of actin filament bundle assembly(GO:0032232)
0.0	0.1	GO:0051489	regulation of filopodium assembly(GO:0051489)
0.0	0.0	GO:0001661	conditioned taste aversion(GO:0001661)
0.0	0.0	GO:0071364	cellular response to epidermal growth factor stimulus(GO:0071364)
0.0	0.1	GO:0019673	GDP-mannose metabolic process(GO:0019673)
0.0	0.2	GO:0008105	asymmetric protein localization(GO:0008105)
0.0	0.0	GO:0002540	arachidonic acid metabolite production involved in inflammatory response(GO:0002538) leukotriene production involved in inflammatory response(GO:0002540)
0.0	0.0	GO:0002710	negative regulation of T cell mediated immunity(GO:0002710)
0.0	0.1	GO:0006498	N-terminal protein lipidation(GO:0006498)
0.0	0.0	GO:0046512	diol biosynthetic process(GO:0034312) sphingosine biosynthetic process(GO:0046512)
0.0	0.1	GO:1903429	regulation of neuron maturation(GO:0014041) regulation of cell maturation(GO:1903429)
0.0	0.2	GO:0030206	chondroitin sulfate biosynthetic process(GO:0030206)
0.0	0.1	GO:0043653	mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.0	0.1	GO:0008653	lipopolysaccharide metabolic process(GO:0008653)
0.0	0.2	GO:0000381	regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0	0.1	GO:0021778	spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) oligodendrocyte cell fate specification(GO:0021778) glial cell fate specification(GO:0021780)
0.0	0.1	GO:0042023	regulation of DNA endoreduplication(GO:0032875) negative regulation of DNA endoreduplication(GO:0032876) DNA endoreduplication(GO:0042023)
0.0	0.1	GO:0019987	obsolete negative regulation of anti-apoptosis(GO:0019987)
0.0	0.0	GO:0072217	negative regulation of metanephros development(GO:0072217)
0.0	0.1	GO:0035751	lysosomal lumen acidification(GO:0007042) regulation of lysosomal lumen pH(GO:0035751)
0.0	0.1	GO:0018076	N-terminal peptidyl-lysine acetylation(GO:0018076)
0.0	0.1	GO:0006855	drug transmembrane transport(GO:0006855)
0.0	0.1	GO:0006003	fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0	0.1	GO:0008340	determination of adult lifespan(GO:0008340)
0.0	0.1	GO:0006422	aspartyl-tRNA aminoacylation(GO:0006422)
0.0	0.1	GO:0060710	chorio-allantoic fusion(GO:0060710)
0.0	0.1	GO:0042921	glucocorticoid receptor signaling pathway(GO:0042921)
0.0	0.1	GO:0051970	negative regulation of transmission of nerve impulse(GO:0051970)
0.0	0.2	GO:0016180	snRNA processing(GO:0016180)
0.0	0.1	GO:0016576	histone dephosphorylation(GO:0016576)
0.0	0.0	GO:0002248	connective tissue replacement involved in inflammatory response wound healing(GO:0002248) connective tissue replacement(GO:0097709)
0.0	0.0	GO:0007571	age-dependent response to oxidative stress(GO:0001306) age-dependent general metabolic decline(GO:0007571)
0.0	0.1	GO:0006474	N-terminal protein amino acid acetylation(GO:0006474)
0.0	0.1	GO:0003056	regulation of vascular smooth muscle contraction(GO:0003056)
0.0	0.0	GO:0034625	fatty acid elongation, monounsaturated fatty acid(GO:0034625)
0.0	0.1	GO:0035335	peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0	0.4	GO:0050690	regulation of defense response to virus by virus(GO:0050690)
0.0	0.1	GO:0060023	soft palate development(GO:0060023)
0.0	0.1	GO:0019885	antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.0	0.1	GO:0032693	negative regulation of interleukin-10 production(GO:0032693)
0.0	0.0	GO:0060433	bronchus development(GO:0060433)
0.0	0.1	GO:0035092	sperm chromatin condensation(GO:0035092)
0.0	0.1	GO:0070389	chaperone cofactor-dependent protein refolding(GO:0070389)
0.0	0.1	GO:0010457	centriole-centriole cohesion(GO:0010457)
0.0	0.1	GO:0032455	nerve growth factor processing(GO:0032455)
0.0	0.0	GO:0022009	establishment of endothelial blood-brain barrier(GO:0014045) central nervous system vasculogenesis(GO:0022009)
0.0	0.1	GO:0046831	regulation of RNA export from nucleus(GO:0046831)
0.0	0.1	GO:0032878	regulation of establishment or maintenance of cell polarity(GO:0032878)
0.0	0.1	GO:0043628	ncRNA 3'-end processing(GO:0043628)
0.0	0.2	GO:0034199	activation of protein kinase A activity(GO:0034199)
0.0	0.0	GO:0061154	endothelial tube morphogenesis(GO:0061154)
0.0	0.0	GO:0001574	ganglioside biosynthetic process(GO:0001574)
0.0	0.0	GO:0090005	negative regulation of establishment of protein localization to plasma membrane(GO:0090005) negative regulation of protein localization to plasma membrane(GO:1903077) negative regulation of protein localization to cell periphery(GO:1904376)
0.0	0.0	GO:0003161	cardiac conduction system development(GO:0003161)
0.0	0.1	GO:0032753	positive regulation of interleukin-4 production(GO:0032753)
0.0	0.1	GO:0071157	negative regulation of cell cycle arrest(GO:0071157)
0.0	0.1	GO:0060292	long term synaptic depression(GO:0060292)
0.0	0.0	GO:0010586	miRNA metabolic process(GO:0010586) miRNA catabolic process(GO:0010587)
0.0	0.1	GO:0046655	folic acid metabolic process(GO:0046655)
0.0	0.0	GO:0002313	mature B cell differentiation involved in immune response(GO:0002313)
0.0	0.2	GO:0046854	phosphatidylinositol phosphorylation(GO:0046854)
0.0	0.0	GO:0043374	CD8-positive, alpha-beta T cell activation(GO:0036037) CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0	0.1	GO:0060158	phospholipase C-activating dopamine receptor signaling pathway(GO:0060158)
0.0	0.0	GO:0034720	histone H3-K4 demethylation(GO:0034720)
0.0	0.1	GO:0002138	retinoic acid biosynthetic process(GO:0002138) diterpenoid biosynthetic process(GO:0016102)
0.0	0.0	GO:0070672	response to interleukin-15(GO:0070672)
0.0	0.1	GO:0007256	activation of JNKK activity(GO:0007256)
0.0	0.0	GO:0042726	flavin-containing compound metabolic process(GO:0042726)
0.0	0.0	GO:0008054	negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation(GO:0008054)
0.0	0.0	GO:0006772	thiamine metabolic process(GO:0006772)
0.0	0.0	GO:0031442	positive regulation of mRNA 3'-end processing(GO:0031442) positive regulation of mRNA processing(GO:0050685) positive regulation of mRNA metabolic process(GO:1903313)
0.0	0.0	GO:0070230	positive regulation of lymphocyte apoptotic process(GO:0070230)
0.0	0.0	GO:0034139	regulation of toll-like receptor 3 signaling pathway(GO:0034139)
0.0	0.0	GO:0019852	L-ascorbic acid metabolic process(GO:0019852)
0.0	0.6	GO:0050852	T cell receptor signaling pathway(GO:0050852)
0.0	0.0	GO:0010572	positive regulation of platelet activation(GO:0010572)
0.0	0.1	GO:0042989	sequestering of actin monomers(GO:0042989)
0.0	0.0	GO:0019731	antibacterial humoral response(GO:0019731)
0.0	0.0	GO:0002032	desensitization of G-protein coupled receptor protein signaling pathway by arrestin(GO:0002032)
0.0	0.0	GO:0009756	carbohydrate mediated signaling(GO:0009756)
0.0	0.1	GO:0034314	Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.0	0.0	GO:0070272	proton-transporting ATP synthase complex assembly(GO:0043461) proton-transporting ATP synthase complex biogenesis(GO:0070272)
0.0	0.0	GO:0060298	positive regulation of sarcomere organization(GO:0060298)
0.0	0.0	GO:0032070	regulation of deoxyribonuclease activity(GO:0032070)
0.0	0.0	GO:0015015	heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0	0.0	GO:0032673	interleukin-4 production(GO:0032633) regulation of interleukin-4 production(GO:0032673)
0.0	0.0	GO:0042339	keratan sulfate metabolic process(GO:0042339)
0.0	0.0	GO:0046607	positive regulation of centrosome cycle(GO:0046607)
0.0	0.0	GO:0045542	positive regulation of cholesterol biosynthetic process(GO:0045542)
0.0	0.0	GO:0019805	quinolinate biosynthetic process(GO:0019805)
0.0	0.0	GO:0006922	obsolete cleavage of lamin involved in execution phase of apoptosis(GO:0006922)
0.0	0.0	GO:0035066	positive regulation of histone acetylation(GO:0035066) positive regulation of protein acetylation(GO:1901985) positive regulation of peptidyl-lysine acetylation(GO:2000758)
0.0	0.1	GO:0060438	trachea development(GO:0060438)
0.0	0.0	GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518) negative regulation of signal transduction by p53 class mediator(GO:1901797)
0.0	0.0	GO:0071459	protein localization to kinetochore(GO:0034501) protein localization to chromosome, centromeric region(GO:0071459)
0.0	0.0	GO:0043931	ossification involved in bone maturation(GO:0043931)
0.0	0.0	GO:0034145	positive regulation of toll-like receptor 4 signaling pathway(GO:0034145)
0.0	0.0	GO:0045059	positive thymic T cell selection(GO:0045059)
0.0	0.0	GO:0045793	positive regulation of cell size(GO:0045793)
0.0	0.3	GO:0006305	DNA alkylation(GO:0006305) DNA methylation(GO:0006306)
0.0	0.1	GO:0007096	regulation of exit from mitosis(GO:0007096)
0.0	0.1	GO:0043984	histone H4-K16 acetylation(GO:0043984)
0.0	0.0	GO:0019276	UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.0	0.0	GO:0048742	regulation of skeletal muscle fiber development(GO:0048742)
0.0	0.0	GO:0072193	positive regulation of smooth muscle cell differentiation(GO:0051152) ureter smooth muscle development(GO:0072191) ureter smooth muscle cell differentiation(GO:0072193)
0.0	0.1	GO:0006658	phosphatidylserine metabolic process(GO:0006658)
0.0	0.1	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress(GO:0070059)
0.0	0.0	GO:0002523	leukocyte migration involved in inflammatory response(GO:0002523)
0.0	0.1	GO:0009812	flavonoid metabolic process(GO:0009812)
0.0	0.0	GO:0009301	snRNA transcription(GO:0009301)
0.0	0.1	GO:0022027	interkinetic nuclear migration(GO:0022027)
0.0	0.0	GO:0030202	heparin metabolic process(GO:0030202)
0.0	0.0	GO:0002282	microglial cell activation involved in immune response(GO:0002282)
0.0	0.0	GO:0019509	L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
0.0	0.1	GO:0002839	regulation of response to tumor cell(GO:0002834) positive regulation of response to tumor cell(GO:0002836) regulation of immune response to tumor cell(GO:0002837) positive regulation of immune response to tumor cell(GO:0002839)
0.0	0.0	GO:0042415	norepinephrine metabolic process(GO:0042415)
0.0	0.0	GO:0009214	cyclic nucleotide catabolic process(GO:0009214)
0.0	0.1	GO:0008635	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c(GO:0008635)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0000942	condensed nuclear chromosome outer kinetochore(GO:0000942)
0.0	0.1	GO:0031313	extrinsic component of vacuolar membrane(GO:0000306) extrinsic component of endosome membrane(GO:0031313)
0.0	0.1	GO:0070022	transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0	0.3	GO:0001891	phagocytic cup(GO:0001891)
0.0	0.1	GO:0071001	U4/U6 snRNP(GO:0071001)
0.0	0.1	GO:0042105	alpha-beta T cell receptor complex(GO:0042105)
0.0	0.1	GO:0034993	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0	0.2	GO:0070688	MLL5-L complex(GO:0070688)
0.0	0.1	GO:0031371	ubiquitin conjugating enzyme complex(GO:0031371)
0.0	0.1	GO:0030056	hemidesmosome(GO:0030056)
0.0	0.1	GO:0071778	obsolete WINAC complex(GO:0071778)
0.0	0.0	GO:0033270	paranode region of axon(GO:0033270)
0.0	0.1	GO:0002178	palmitoyltransferase complex(GO:0002178) serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0	0.1	GO:0005826	actomyosin contractile ring(GO:0005826)
0.0	0.2	GO:0032039	integrator complex(GO:0032039)
0.0	0.1	GO:0031235	intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0	0.1	GO:0014731	spectrin-associated cytoskeleton(GO:0014731)
0.0	0.4	GO:0005871	kinesin complex(GO:0005871)
0.0	0.1	GO:0031265	CD95 death-inducing signaling complex(GO:0031265)
0.0	0.1	GO:0031088	platelet dense granule membrane(GO:0031088)
0.0	0.1	GO:0072487	MSL complex(GO:0072487)
0.0	0.3	GO:0030530	obsolete heterogeneous nuclear ribonucleoprotein complex(GO:0030530)
0.0	0.2	GO:0005952	cAMP-dependent protein kinase complex(GO:0005952)
0.0	0.1	GO:0042101	T cell receptor complex(GO:0042101)
0.0	0.1	GO:0044224	juxtaparanode region of axon(GO:0044224)
0.0	0.1	GO:0005964	phosphorylase kinase complex(GO:0005964)
0.0	0.0	GO:0071986	Ragulator complex(GO:0071986)
0.0	0.1	GO:0005697	telomerase holoenzyme complex(GO:0005697)
0.0	0.1	GO:0031080	nuclear pore outer ring(GO:0031080)
0.0	0.1	GO:0005827	polar microtubule(GO:0005827)
0.0	0.0	GO:0045298	tubulin complex(GO:0045298)
0.0	0.1	GO:0097425	smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.0	0.2	GO:0010494	cytoplasmic stress granule(GO:0010494)
0.0	0.1	GO:0033180	proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0	0.1	GO:0001740	Barr body(GO:0001740)
0.0	0.1	GO:0008250	oligosaccharyltransferase complex(GO:0008250)
0.0	0.1	GO:0005797	Golgi medial cisterna(GO:0005797)
0.0	0.2	GO:0045334	clathrin-coated endocytic vesicle(GO:0045334)
0.0	0.1	GO:0005838	proteasome regulatory particle(GO:0005838)
0.0	0.2	GO:0005942	phosphatidylinositol 3-kinase complex(GO:0005942)
0.0	0.0	GO:1990316	ATG1/ULK1 kinase complex(GO:1990316)
0.0	0.1	GO:0000242	pericentriolar material(GO:0000242)
0.0	0.1	GO:0001772	immunological synapse(GO:0001772)
0.0	0.1	GO:0042589	zymogen granule membrane(GO:0042589)
0.0	0.1	GO:0005678	obsolete chromatin assembly complex(GO:0005678)
0.0	0.1	GO:0005742	mitochondrial outer membrane translocase complex(GO:0005742)
0.0	0.1	GO:0016471	vacuolar proton-transporting V-type ATPase complex(GO:0016471)
0.0	0.0	GO:0005896	interleukin-6 receptor complex(GO:0005896)
0.0	0.1	GO:0034362	low-density lipoprotein particle(GO:0034362)
0.0	0.0	GO:0005588	collagen type V trimer(GO:0005588)
0.0	0.2	GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.0	0.0	GO:0032777	Piccolo NuA4 histone acetyltransferase complex(GO:0032777)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0008454	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.1	0.2	GO:0005094	Rho GDP-dissociation inhibitor activity(GO:0005094)
0.1	0.2	GO:0035184	histone threonine kinase activity(GO:0035184)
0.1	0.2	GO:0005176	ErbB-2 class receptor binding(GO:0005176)
0.0	0.1	GO:0004465	lipoprotein lipase activity(GO:0004465)
0.0	0.1	GO:0016309	1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0	0.2	GO:0034190	apolipoprotein receptor binding(GO:0034190)
0.0	0.1	GO:0001758	retinal dehydrogenase activity(GO:0001758)
0.0	0.1	GO:0047623	AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0	0.1	GO:0016509	long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0016509)
0.0	0.5	GO:0005095	GTPase inhibitor activity(GO:0005095)
0.0	0.2	GO:0004691	cAMP-dependent protein kinase activity(GO:0004691)
0.0	0.2	GO:0031013	troponin I binding(GO:0031013)
0.0	0.2	GO:0016494	C-X-C chemokine receptor activity(GO:0016494)
0.0	0.1	GO:0004062	aryl sulfotransferase activity(GO:0004062)
0.0	0.1	GO:0043024	ribosomal small subunit binding(GO:0043024)
0.0	0.1	GO:0042608	T cell receptor binding(GO:0042608)
0.0	0.1	GO:0016454	serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0	0.1	GO:0016886	ligase activity, forming phosphoric ester bonds(GO:0016886)
0.0	0.1	GO:0008486	diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486)
0.0	0.1	GO:0015226	amino-acid betaine transmembrane transporter activity(GO:0015199) carnitine transmembrane transporter activity(GO:0015226)
0.0	0.1	GO:0032454	histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0	0.2	GO:0008266	poly(U) RNA binding(GO:0008266)
0.0	0.1	GO:0004774	succinate-CoA ligase activity(GO:0004774)
0.0	0.1	GO:0098599	palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0	0.1	GO:0052813	phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.0	0.1	GO:0030284	estrogen receptor activity(GO:0030284)
0.0	0.1	GO:0008379	thioredoxin peroxidase activity(GO:0008379)
0.0	0.1	GO:0050544	arachidonic acid binding(GO:0050544)
0.0	0.1	GO:0000400	four-way junction DNA binding(GO:0000400)
0.0	0.2	GO:0031435	mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0	0.1	GO:0004875	complement receptor activity(GO:0004875)
0.0	0.1	GO:0043141	ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.0	0.1	GO:0070087	chromo shadow domain binding(GO:0070087)
0.0	0.1	GO:0030676	Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0	0.1	GO:0070097	delta-catenin binding(GO:0070097)
0.0	0.1	GO:0048020	CCR chemokine receptor binding(GO:0048020)
0.0	0.1	GO:0031434	mitogen-activated protein kinase kinase binding(GO:0031434)
0.0	0.1	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0	0.1	GO:0008172	S-methyltransferase activity(GO:0008172)
0.0	0.1	GO:0003828	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0	0.1	GO:0003953	NAD+ nucleosidase activity(GO:0003953)
0.0	0.1	GO:0016778	diphosphotransferase activity(GO:0016778)
0.0	0.1	GO:0003829	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0003829)
0.0	0.1	GO:0005092	GDP-dissociation inhibitor activity(GO:0005092)
0.0	0.1	GO:0042043	neurexin family protein binding(GO:0042043)
0.0	0.3	GO:0030159	receptor signaling complex scaffold activity(GO:0030159)
0.0	0.2	GO:0034593	phosphatidylinositol bisphosphate phosphatase activity(GO:0034593)
0.0	0.1	GO:0070568	guanylyltransferase activity(GO:0070568)
0.0	0.1	GO:0045569	TRAIL binding(GO:0045569)
0.0	0.1	GO:0003873	6-phosphofructo-2-kinase activity(GO:0003873)
0.0	0.1	GO:0008900	hydrogen:potassium-exchanging ATPase activity(GO:0008900)
0.0	0.1	GO:0034713	type I transforming growth factor beta receptor binding(GO:0034713)
0.0	0.1	GO:0070577	lysine-acetylated histone binding(GO:0070577)
0.0	0.1	GO:0048156	tau protein binding(GO:0048156)
0.0	0.1	GO:0033691	sialic acid binding(GO:0033691)
0.0	0.1	GO:0047756	chondroitin 4-sulfotransferase activity(GO:0047756)
0.0	0.1	GO:0000247	C-8 sterol isomerase activity(GO:0000247)
0.0	0.1	GO:0034452	dynactin binding(GO:0034452)
0.0	0.1	GO:0004815	aspartate-tRNA ligase activity(GO:0004815)
0.0	0.1	GO:0015271	outward rectifier potassium channel activity(GO:0015271)
0.0	0.2	GO:0008536	Ran GTPase binding(GO:0008536)
0.0	0.0	GO:0004719	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.0	0.1	GO:0000977	transcription regulatory region sequence-specific DNA binding(GO:0000976) RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977) RNA polymerase II regulatory region DNA binding(GO:0001012)
0.0	0.2	GO:0004697	protein kinase C activity(GO:0004697)
0.0	0.0	GO:0032137	guanine/thymine mispair binding(GO:0032137)
0.0	0.1	GO:0004689	phosphorylase kinase activity(GO:0004689)
0.0	0.1	GO:0031685	adenosine receptor binding(GO:0031685)
0.0	0.0	GO:0035198	miRNA binding(GO:0035198)
0.0	0.1	GO:0008409	5'-3' exonuclease activity(GO:0008409)
0.0	0.1	GO:0004576	oligosaccharyl transferase activity(GO:0004576)
0.0	0.2	GO:0008373	sialyltransferase activity(GO:0008373)
0.0	0.1	GO:0016857	racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.0	0.0	GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0	0.1	GO:0016934	extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.0	0.2	GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0	0.1	GO:0043560	insulin receptor substrate binding(GO:0043560)
0.0	0.1	GO:0050733	RS domain binding(GO:0050733)
0.0	0.1	GO:0005131	growth hormone receptor binding(GO:0005131)
0.0	0.1	GO:0001784	phosphotyrosine binding(GO:0001784)
0.0	0.3	GO:0003950	NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0	0.1	GO:0016595	glutamate binding(GO:0016595)
0.0	0.0	GO:0032139	dinucleotide insertion or deletion binding(GO:0032139)
0.0	0.1	GO:0000828	inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832)
0.0	0.1	GO:0004017	adenylate kinase activity(GO:0004017)
0.0	0.1	GO:0017091	AU-rich element binding(GO:0017091)
0.0	0.2	GO:0046933	proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0	0.0	GO:0036002	pre-mRNA binding(GO:0036002)
0.0	0.1	GO:0005388	calcium-transporting ATPase activity(GO:0005388)
0.0	0.1	GO:0030275	LRR domain binding(GO:0030275)
0.0	0.0	GO:0045499	chemorepellent activity(GO:0045499)
0.0	0.0	GO:0004939	beta-adrenergic receptor activity(GO:0004939)
0.0	0.1	GO:0005522	profilin binding(GO:0005522)
0.0	0.2	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0	0.0	GO:0000900	translation repressor activity, nucleic acid binding(GO:0000900)
0.0	0.2	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0	0.0	GO:0000064	L-ornithine transmembrane transporter activity(GO:0000064)
0.0	0.2	GO:0001608	G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0	0.2	GO:0016505	peptidase activator activity involved in apoptotic process(GO:0016505)
0.0	0.1	GO:0015924	mannosyl-oligosaccharide mannosidase activity(GO:0015924)
0.0	0.1	GO:0016493	C-C chemokine receptor activity(GO:0016493)
0.0	0.0	GO:0008109	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0	0.6	GO:0008301	DNA binding, bending(GO:0008301)
0.0	0.0	GO:0004911	interleukin-2 receptor activity(GO:0004911)
0.0	0.2	GO:0005086	ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0	0.1	GO:0035251	UDP-glucosyltransferase activity(GO:0035251)
0.0	0.1	GO:0005138	interleukin-6 receptor binding(GO:0005138)
0.0	0.2	GO:0005164	tumor necrosis factor receptor binding(GO:0005164)
0.0	0.2	GO:0005487	nucleocytoplasmic transporter activity(GO:0005487)
0.0	0.1	GO:0031593	polyubiquitin binding(GO:0031593)
0.0	0.1	GO:0043425	bHLH transcription factor binding(GO:0043425)
0.0	0.0	GO:0043398	HLH domain binding(GO:0043398)
0.0	0.0	GO:0008821	crossover junction endodeoxyribonuclease activity(GO:0008821)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.4	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.3	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.6	PID REELIN PATHWAY	Reelin signaling pathway
0.9	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0	PID IL5 PATHWAY	IL5-mediated signaling events
0.0	ST GRANULE CELL SURVIVAL PATHWAY	Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.1	PID P38 ALPHA BETA DOWNSTREAM PATHWAY	Signaling mediated by p38-alpha and p38-beta
0.3	PID THROMBIN PAR4 PATHWAY	PAR4-mediated thrombin signaling events
0.5	PID PI3KCI PATHWAY	Class I PI3K signaling events
0.2	PID AVB3 OPN PATHWAY	Osteopontin-mediated events
0.4	PID HIV NEF PATHWAY	HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.3	PID IL8 CXCR2 PATHWAY	IL8- and CXCR2-mediated signaling events
0.1	ST INTERLEUKIN 4 PATHWAY	Interleukin 4 (IL-4) Pathway
0.5	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
0.2	PID GMCSF PATHWAY	GMCSF-mediated signaling events
0.1	ST GAQ PATHWAY	G alpha q Pathway
0.1	PID TRAIL PATHWAY	TRAIL signaling pathway
0.1	PID CXCR3 PATHWAY	CXCR3-mediated signaling events
0.0	PID INTEGRIN3 PATHWAY	Beta3 integrin cell surface interactions
0.3	PID ANGIOPOIETIN RECEPTOR PATHWAY	Angiopoietin receptor Tie2-mediated signaling
0.4	PID NFAT 3PATHWAY	Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.0	ST G ALPHA S PATHWAY	G alpha s Pathway
0.3	PID CASPASE PATHWAY	Caspase cascade in apoptosis
0.0	PID S1P S1P4 PATHWAY	S1P4 pathway
0.1	PID IL12 STAT4 PATHWAY	IL12 signaling mediated by STAT4
0.1	PID RB 1PATHWAY	Regulation of retinoblastoma protein
0.1	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.2	PID INTEGRIN A4B1 PATHWAY	Alpha4 beta1 integrin signaling events
0.1	ST IL 13 PATHWAY	Interleukin 13 (IL-13) Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.5	REACTOME N GLYCAN ANTENNAE ELONGATION	Genes involved in N-Glycan antennae elongation
0.4	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
0.3	REACTOME CD28 DEPENDENT VAV1 PATHWAY	Genes involved in CD28 dependent Vav1 pathway
0.0	REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1	Genes involved in Autodegradation of the E3 ubiquitin ligase COP1
0.4	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.2	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.4	REACTOME CTLA4 INHIBITORY SIGNALING	Genes involved in CTLA4 inhibitory signaling
0.1	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.2	REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS	Genes involved in Trafficking of GluR2-containing AMPA receptors
0.4	REACTOME DOWNSTREAM TCR SIGNALING	Genes involved in Downstream TCR signaling
0.2	REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.2	REACTOME NEPHRIN INTERACTIONS	Genes involved in Nephrin interactions
0.3	REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB	Genes involved in PKA-mediated phosphorylation of CREB
0.0	REACTOME SPRY REGULATION OF FGF SIGNALING	Genes involved in Spry regulation of FGF signaling
0.0	REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS	Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.1	REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES	Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0	REACTOME PHOSPHORYLATION OF THE APC C	Genes involved in Phosphorylation of the APC/C
0.2	REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
0.2	REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION	Genes involved in Transport to the Golgi and subsequent modification
0.2	REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS	Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.1	REACTOME P2Y RECEPTORS	Genes involved in P2Y receptors
0.2	REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	Genes involved in Regulation of gene expression in beta cells
0.2	REACTOME CHOLESTEROL BIOSYNTHESIS	Genes involved in Cholesterol biosynthesis
0.2	REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE	Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.1	REACTOME GPVI MEDIATED ACTIVATION CASCADE	Genes involved in GPVI-mediated activation cascade
0.2	REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	Genes involved in Sema4D induced cell migration and growth-cone collapse
0.1	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.0	REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY	Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.0	REACTOME NRIF SIGNALS CELL DEATH FROM THE NUCLEUS	Genes involved in NRIF signals cell death from the nucleus
0.1	REACTOME REGULATION OF SIGNALING BY CBL	Genes involved in Regulation of signaling by CBL
0.0	REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING	Genes involved in Advanced glycosylation endproduct receptor signaling
0.1	REACTOME IL 6 SIGNALING	Genes involved in Interleukin-6 signaling