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ENCODE: H3K4me1 ChIP-Seq of primary human cells
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Results for PBX2

Z-value: 1.11

Motif logo

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Transcription factors associated with PBX2

Gene Symbol Gene ID Gene Info
PBX2
ENSG00000204304.7 PBX homeobox 2

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr6_32156684_32156948PBX211470.2443800.862.7e-03Click!
chr6_32155779_32155970PBX220890.1299790.791.2e-02Click!
chr6_32156186_32156415PBX216630.1621410.781.4e-02Click!
chr6_32158792_32159044PBX29550.2871180.665.4e-02Click!
chr6_32155397_32155696PBX224170.1148040.531.4e-01Click!

Activity of the PBX2 motif across conditions

Conditions sorted by the z-value of the PBX2 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr1_26696466_26696677 0.74 ZNF683
 zinc finger protein 683
 665
 0.58
chr3_71451560_71451730 0.54 FOXP1
 forkhead box P1
 97734
 0.08
chr7_50306943_50307629 0.53 IKZF1
 IKAROS family zinc finger 1 (Ikaros)
 37038
 0.2
chr12_93827062_93827301 0.48 UBE2N
 ubiquitin-conjugating enzyme E2N
 7851
 0.16
chr1_145396953_145397104 0.48 ENSG00000201558
 .
 14271
 0.13
chr10_3915023_3915255 0.48 KLF6
 Kruppel-like factor 6
 87666
 0.09
chr10_7554785_7554936 0.47 RP11-385N23.1
20309
 0.21
chr13_95837972_95838123 0.47 ENSG00000238463
 .
 24551
 0.24
chr2_158276348_158276584 0.46 CYTIP
 cytohesin 1 interacting protein
 19460
 0.2
chr8_37127586_37127737 0.45 RP11-150O12.6
246878
 0.02
chr14_78224263_78224414 0.44 C14orf178
 chromosome 14 open reading frame 178
 2835
 0.18
chr11_48019132_48019288 0.44 PTPRJ
 protein tyrosine phosphatase, receptor type, J
 16931
 0.19
chr5_7778754_7778905 0.43 RP11-711G10.1
28950
 0.2
chr12_92423583_92424054 0.43 C12orf79
 chromosome 12 open reading frame 79
 106979
 0.07
chr9_2154852_2155076 0.41 SMARCA2
 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
 2716
 0.31
chr2_204721588_204721739 0.41 CTLA4
 cytotoxic T-lymphocyte-associated protein 4
 10846
 0.25
chr10_74051154_74051347 0.40 RP11-442H21.2
15512
 0.15
chr8_20057388_20057552 0.40 ATP6V1B2
 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2
 2520
 0.27
chr17_40423553_40423822 0.39 AC003104.1
298
 0.83
chr1_90223591_90223869 0.39 ENSG00000239176
 .
 10147
 0.21
chr14_102306035_102306224 0.38 CTD-2017C7.1
261
 0.91
chr15_55514570_55514956 0.38 RSL24D1
 ribosomal L24 domain containing 1
 25498
 0.18
chr2_99084461_99084735 0.37 INPP4A
 inositol polyphosphate-4-phosphatase, type I, 107kDa
 23185
 0.21
chr2_99378186_99378507 0.37 ENSG00000201070
 .
 20527
 0.19
chr7_2739468_2739742 0.37 AMZ1
 archaelysin family metallopeptidase 1
 11769
 0.21
chr17_76722732_76723209 0.37 CYTH1
 cytohesin 1
 1077
 0.54
chr7_77433899_77434050 0.36 PHTF2
 putative homeodomain transcription factor 2
 5756
 0.21
chr5_55152116_55152357 0.36 IL31RA
 interleukin 31 receptor A
 2878
 0.28
chr9_100666794_100667000 0.36 C9orf156
 chromosome 9 open reading frame 156
 7856
 0.16
chr12_65011200_65011351 0.35 ENSG00000207546
 .
 5014
 0.14
chr2_204868825_204868976 0.35 ICOS
 inducible T-cell co-stimulator
 67397
 0.13
chr3_153398482_153398633 0.35 ENSG00000200162
 .
 73391
 0.11
chr15_64183841_64184299 0.35 ENSG00000199156
 .
 20852
 0.19
chr16_57057139_57057438 0.35 NLRC5
 NLR family, CARD domain containing 5
 2311
 0.23
chr3_20147752_20147943 0.34 ENSG00000266745
 .
 31210
 0.16
chr6_24957255_24957453 0.34 FAM65B
 family with sequence similarity 65, member B
 21166
 0.2
chrY_1649865_1650016 0.34 NA
 NA
 > 106
 NA
chr6_157183759_157183935 0.34 ARID1B
 AT rich interactive domain 1B (SWI1-like)
 38660
 0.19
chrX_1699864_1700015 0.34 AKAP17A
 A kinase (PRKA) anchor protein 17A
 10547
 0.21
chr4_40231477_40231628 0.34 RHOH
 ras homolog family member H
 29588
 0.18
chr19_48761122_48761385 0.34 CARD8
 caspase recruitment domain family, member 8
 2050
 0.19
chr20_21530099_21530250 0.34 NKX2-2
 NK2 homeobox 2
 35510
 0.17
chr9_130544245_130544396 0.33 SH2D3C
 SH2 domain containing 3C
 3300
 0.11
chr16_23877339_23877739 0.33 PRKCB
 protein kinase C, beta
 28995
 0.21
chr7_50301242_50301499 0.33 IKZF1
 IKAROS family zinc finger 1 (Ikaros)
 42954
 0.18
chr11_10479399_10479700 0.32 AMPD3
 adenosine monophosphate deaminase 3
 1816
 0.36
chr12_40077357_40077585 0.32 C12orf40
 chromosome 12 open reading frame 40
 57486
 0.13
chr7_37398412_37398702 0.32 ELMO1
 engulfment and cell motility 1
 5285
 0.22
chr7_142426324_142426678 0.32 PRSS1
 protease, serine, 1 (trypsin 1)
 30818
 0.16
chr8_27222846_27223110 0.32 PTK2B
 protein tyrosine kinase 2 beta
 15190
 0.21
chr17_267560_267799 0.31 AC108004.3
3865
 0.17
chr3_196396917_196397068 0.31 PIGX
 phosphatidylinositol glycan anchor biosynthesis, class X
 30346
 0.1
chrX_1699314_1699465 0.31 AKAP17A
 A kinase (PRKA) anchor protein 17A
 11097
 0.2
chr1_208049687_208049852 0.31 CD34
 CD34 molecule
 14068
 0.26
chr7_38272993_38273191 0.31 STARD3NL
 STARD3 N-terminal like
 55095
 0.17
chr11_60817313_60817464 0.31 CD6
 CD6 molecule
 41382
 0.1
chr1_108330403_108330665 0.31 ENSG00000265536
 .
 11656
 0.26
chr11_121329085_121329622 0.30 RP11-730K11.1
5631
 0.26
chr5_156623615_156623766 0.30 ITK
 IL2-inducible T-cell kinase
 15853
 0.12
chr1_101748824_101749089 0.30 RP4-575N6.5
40242
 0.14
chr7_37349133_37349657 0.30 ELMO1
 engulfment and cell motility 1
 32972
 0.18
chr17_76172343_76172703 0.30 SYNGR2
 synaptogyrin 2
 7284
 0.11
chr1_40526792_40526943 0.30 CAP1
 CAP, adenylate cyclase-associated protein 1 (yeast)
 20313
 0.16
chr18_52520228_52520804 0.30 RAB27B
 RAB27B, member RAS oncogene family
 25086
 0.21
chr17_53147200_53147351 0.30 STXBP4
 syntaxin binding protein 4
 70098
 0.12
chrY_1649313_1649464 0.29 NA
 NA
 > 106
 NA
chr22_47009198_47009548 0.29 GRAMD4
 GRAM domain containing 4
 6926
 0.25
chr12_4059299_4059530 0.29 RP11-664D1.1
45028
 0.18
chr10_7301219_7301413 0.29 SFMBT2
 Scm-like with four mbt domains 2
 149391
 0.04
chr5_151335887_151336038 0.28 GLRA1
 glycine receptor, alpha 1
 31559
 0.21
chr1_42271230_42271400 0.28 ENSG00000264896
 .
 46503
 0.18
chr3_46142236_46142387 0.28 CCR3
 chemokine (C-C motif) receptor 3
 62785
 0.1
chr5_55909103_55909387 0.28 AC022431.2
 Homo sapiens uncharacterized LOC101928448 (LOC101928448), mRNA.
 7186
 0.27
chr6_144740266_144740510 0.28 UTRN
 utrophin
 75151
 0.11
chr14_61884442_61884698 0.28 PRKCH
 protein kinase C, eta
 24706
 0.21
chr11_2399386_2399879 0.28 ENSG00000238184
 .
 410
 0.6
chr2_27255490_27255641 0.27 TMEM214
 transmembrane protein 214
 257
 0.8
chr17_66343606_66343891 0.27 ARSG
 arylsulfatase G
 56089
 0.1
chr7_77345751_77345902 0.27 RSBN1L
 round spermatid basic protein 1-like
 19358
 0.23
chr1_31533317_31533468 0.27 PUM1
 pumilio RNA-binding family member 1
 1371
 0.51
chr1_65342372_65342702 0.27 JAK1
 Janus kinase 1
 89650
 0.08
chrX_70839652_70840082 0.27 CXCR3
 chemokine (C-X-C motif) receptor 3
 1500
 0.39
chr5_118524120_118524302 0.27 ENSG00000264536
 .
 33879
 0.15
chr12_92520593_92520744 0.27 C12orf79
 chromosome 12 open reading frame 79
 10129
 0.18
chr7_36325933_36326467 0.27 EEPD1
 endonuclease/exonuclease/phosphatase family domain containing 1
 10553
 0.18
chr3_59975455_59975606 0.26 NPCDR1
 nasopharyngeal carcinoma, down-regulated 1
 17947
 0.31
chr19_18416810_18417169 0.26 LSM4
 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
 10080
 0.09
chr13_51466339_51466600 0.26 RNASEH2B-AS1
 RNASEH2B antisense RNA 1
 691
 0.7
chr1_93003931_93004098 0.26 GFI1
 growth factor independent 1 transcription repressor
 51581
 0.15
chr2_38881811_38882051 0.26 GALM
 galactose mutarotase (aldose 1-epimerase)
 11121
 0.17
chr9_92041929_92042366 0.26 SEMA4D
 sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
 8399
 0.25
chr15_58812240_58812391 0.26 RP11-50C13.2
1195
 0.47
chr2_143943517_143943668 0.26 RP11-190J23.1
13851
 0.27
chr7_128581367_128581518 0.26 IRF5
 interferon regulatory factor 5
 716
 0.63
chr1_9713515_9713810 0.26 C1orf200
 chromosome 1 open reading frame 200
 982
 0.47
chr17_80359730_80359914 0.26 RP13-20L14.4
564
 0.55
chr6_135339984_135340183 0.26 HBS1L
 HBS1-like (S. cerevisiae)
 8211
 0.22
chr15_52975597_52975763 0.25 FAM214A
 family with sequence similarity 214, member A
 4111
 0.27
chr14_61887636_61887875 0.25 PRKCH
 protein kinase C, eta
 21521
 0.22
chr5_169074930_169075085 0.25 DOCK2
 dedicator of cytokinesis 2
 10756
 0.25
chr14_31045998_31046149 0.25 G2E3
 G2/M-phase specific E3 ubiquitin protein ligase
 889
 0.61
chr7_144474434_144474585 0.25 TPK1
 thiamin pyrophosphokinase 1
 38494
 0.2
chr2_149633605_149633756 0.25 KIF5C
 kinesin family member 5C
 861
 0.6
chr5_130728180_130728357 0.25 CDC42SE2
 CDC42 small effector 2
 6969
 0.31
chr1_161035238_161035389 0.25 AL591806.1
 Uncharacterized protein
 342
 0.73
chr1_154529530_154529831 0.25 UBE2Q1
 ubiquitin-conjugating enzyme E2Q family member 1
 1429
 0.27
chr7_12770523_12770759 0.25 ENSG00000199470
 .
 30127
 0.2
chr12_111018423_111018574 0.25 PPTC7
 PTC7 protein phosphatase homolog (S. cerevisiae)
 2627
 0.23
chr6_36516425_36516576 0.25 STK38
 serine/threonine kinase 38
 1253
 0.39
chr2_24552663_24552963 0.25 ITSN2
 intersectin 2
 30365
 0.17
chr3_112274584_112274735 0.25 SLC35A5
 solute carrier family 35, member A5
 5897
 0.2
chr5_70884636_70884801 0.25 MCCC2
 methylcrotonoyl-CoA carboxylase 2 (beta)
 1523
 0.47
chr6_135409772_135409953 0.25 HBS1L
 HBS1-like (S. cerevisiae)
 14332
 0.21
chr12_122986187_122986338 0.24 ZCCHC8
 zinc finger, CCHC domain containing 8
 744
 0.61
chr8_61488613_61488764 0.24 RAB2A
 RAB2A, member RAS oncogene family
 8594
 0.24
chr3_69331473_69331660 0.24 FRMD4B
 FERM domain containing 4B
 10646
 0.29
chrX_44105289_44105582 0.24 EFHC2
 EF-hand domain (C-terminal) containing 2
 97483
 0.08
chr3_48129253_48129632 0.24 MAP4
 microtubule-associated protein 4
 872
 0.58
chr16_28306696_28306847 0.24 SBK1
 SH3 domain binding kinase 1
 2931
 0.27
chr1_118159462_118159660 0.24 FAM46C
 family with sequence similarity 46, member C
 11005
 0.21
chr6_36854300_36854600 0.24 C6orf89
 chromosome 6 open reading frame 89
 810
 0.61
chr9_79038613_79038764 0.24 GCNT1
 glucosaminyl (N-acetyl) transferase 1, core 2
 3936
 0.3
chr6_91003875_91004215 0.24 BACH2
 BTB and CNC homology 1, basic leucine zipper transcription factor 2
 2416
 0.36
chr9_117129330_117129481 0.23 AKNA
 AT-hook transcription factor
 9839
 0.2
chr2_9540803_9540954 0.23 ITGB1BP1
 integrin beta 1 binding protein 1
 19545
 0.18
chr2_158305057_158305360 0.23 CYTIP
 cytohesin 1 interacting protein
 4554
 0.25
chr3_105470829_105471066 0.23 CBLB
 Cbl proto-oncogene B, E3 ubiquitin protein ligase
 49902
 0.2
chr9_78641008_78641159 0.23 PCSK5
 proprotein convertase subtilisin/kexin type 5
 69810
 0.13
chr5_75687734_75687885 0.23 IQGAP2
 IQ motif containing GTPase activating protein 2
 11265
 0.27
chr19_48748323_48748474 0.23 CARD8
 caspase recruitment domain family, member 8
 4078
 0.14
chr14_99646768_99646919 0.23 AL162151.4
22090
 0.23
chr13_51995049_51995200 0.23 INTS6
 integrator complex subunit 6
 386
 0.83
chr12_21768112_21768692 0.23 GYS2
 glycogen synthase 2 (liver)
 10621
 0.19
chr3_30663550_30663701 0.23 TGFBR2
 transforming growth factor, beta receptor II (70/80kDa)
 15532
 0.28
chr15_86104644_86104795 0.23 AKAP13
 A kinase (PRKA) anchor protein 13
 6042
 0.2
chr1_167598592_167598792 0.23 RCSD1
 RCSD domain containing 1
 638
 0.62
chr18_9082924_9083342 0.23 NDUFV2
 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa
 19495
 0.17
chr7_50461724_50462037 0.23 ENSG00000200815
 .
 41198
 0.16
chr5_112714195_112714492 0.23 CTD-2201G3.1
54932
 0.13
chr5_50006083_50006243 0.23 PARP8
 poly (ADP-ribose) polymerase family, member 8
 42772
 0.22
chr13_28017259_28017410 0.22 MTIF3
 mitochondrial translational initiation factor 3
 6992
 0.17
chr6_34361725_34361876 0.22 NUDT3
 nudix (nucleoside diphosphate linked moiety X)-type motif 3
 1349
 0.42
chr2_160579118_160579420 0.22 MARCH7
 membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase
 10251
 0.25
chr9_120588985_120589386 0.22 ENSG00000251847
 .
 95436
 0.08
chr3_13388775_13388976 0.22 NUP210
 nucleoporin 210kDa
 72934
 0.11
chr6_15278908_15279059 0.22 JARID2
 jumonji, AT rich interactive domain 2
 29840
 0.15
chr7_116651601_116651894 0.22 ST7
 suppression of tumorigenicity 7
 3195
 0.23
chr3_71094319_71094756 0.22 FOXP1
 forkhead box P1
 19540
 0.28
chr9_20378989_20379416 0.22 MLLT3
 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
 3265
 0.26
chr3_151981214_151981600 0.22 MBNL1
 muscleblind-like splicing regulator 1
 4422
 0.25
chr20_57696300_57696451 0.22 ZNF831
 zinc finger protein 831
 69700
 0.09
chr22_23164320_23164502 0.22 IGLV2-8
 immunoglobulin lambda variable 2-8
 742
 0.25
chr12_8222666_8222831 0.22 C3AR1
 complement component 3a receptor 1
 3681
 0.18
chr12_69068762_69069251 0.22 NUP107
 nucleoporin 107kDa
 11508
 0.2
chr12_105158634_105158785 0.22 ENSG00000222579
 .
 86893
 0.09
chr6_118003746_118003897 0.22 NUS1
 nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae)
 7156
 0.29
chr13_75896952_75897103 0.22 TBC1D4
 TBC1 domain family, member 4
 18640
 0.24
chr12_66704736_66704887 0.22 HELB
 helicase (DNA) B
 8486
 0.17
chr4_40245605_40245832 0.22 RHOH
 ras homolog family member H
 43754
 0.15
chr18_2573236_2573505 0.22 NDC80
 NDC80 kinetochore complex component
 1806
 0.24
chr14_64340480_64340720 0.22 SYNE2
 spectrin repeat containing, nuclear envelope 2
 20868
 0.2
chr10_8099455_8099947 0.22 GATA3
 GATA binding protein 3
 2932
 0.41
chr6_25028483_25028634 0.22 ENSG00000244618
 .
 2952
 0.25
chr8_127513116_127513267 0.22 ENSG00000207138
 .
 3817
 0.28
chr10_15212173_15212438 0.21 NMT2
 N-myristoyltransferase 2
 1613
 0.42
chr20_58712383_58712535 0.21 C20orf197
 chromosome 20 open reading frame 197
 81479
 0.1
chr1_14058388_14058781 0.21 PRDM2
 PR domain containing 2, with ZNF domain
 17314
 0.21
chr1_93653739_93653893 0.21 TMED5
 transmembrane emp24 protein transport domain containing 5
 7531
 0.19
chr16_3623403_3623748 0.21 NLRC3
 NLR family, CARD domain containing 3
 3817
 0.17
chr4_148972313_148972526 0.21 RP11-76G10.1
95203
 0.09
chr17_47434205_47434356 0.21 ZNF652
 zinc finger protein 652
 5198
 0.14
chr5_79476055_79476349 0.21 CTC-458I2.2
52018
 0.12
chr3_186635155_186635311 0.21 ST6GAL1
 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
 13041
 0.17
chr4_118787870_118788021 0.21 NDST3
 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
 167555
 0.04
chr14_100549474_100549745 0.21 CTD-2376I20.1
8394
 0.14
chr20_45622950_45623101 0.21 EYA2
 eyes absent homolog 2 (Drosophila)
 4385
 0.32
chr17_62965165_62965316 0.21 AMZ2P1
 archaelysin family metallopeptidase 2 pseudogene 1
 4395
 0.17
chr2_197026509_197026798 0.21 STK17B
 serine/threonine kinase 17b
 5282
 0.22
chr2_28996370_28996521 0.21 PPP1CB
 protein phosphatase 1, catalytic subunit, beta isozyme
 5421
 0.19
chr3_111391150_111391301 0.21 PLCXD2
 phosphatidylinositol-specific phospholipase C, X domain containing 2
 2298
 0.3
chr7_72705805_72706094 0.21 GTF2IRD2P1
 GTF2I repeat domain containing 2 pseudogene 1
 11806
 0.13
chr14_91829300_91829451 0.21 ENSG00000265856
 .
 29318
 0.18
chr7_96314992_96315143 0.21 SHFM1
 split hand/foot malformation (ectrodactyly) type 1
 24096
 0.26
chr13_47225060_47225405 0.20 LRCH1
 leucine-rich repeats and calponin homology (CH) domain containing 1
 28739
 0.24
chr16_9043089_9043275 0.20 USP7
 ubiquitin specific peptidase 7 (herpes virus-associated)
 7055
 0.21
chr10_99895864_99896043 0.20 R3HCC1L
 R3H domain and coiled-coil containing 1-like
 1525
 0.51
chr22_23134104_23134282 0.20 ENSG00000207833
 .
 784
 0.23
chr10_22946008_22946242 0.20 PIP4K2A
 phosphatidylinositol-5-phosphate 4-kinase, type II, alpha
 56912
 0.15
chr18_60822595_60822747 0.20 RP11-299P2.1
4118
 0.28
chr20_37432775_37433181 0.20 PPP1R16B
 protein phosphatase 1, regulatory subunit 16B
 1370
 0.43
chr6_144499684_144499835 0.20 STX11
 syntaxin 11
 28096
 0.21
chr8_81052812_81053539 0.20 RP11-92K15.1
18088
 0.19
chr7_129260518_129260719 0.20 NRF1
 nuclear respiratory factor 1
 9021
 0.24
chr2_42327539_42327704 0.20 PKDCC
 protein kinase domain containing, cytoplasmic
 52461
 0.13
chr9_100668728_100668903 0.20 C9orf156
 chromosome 9 open reading frame 156
 5938
 0.17
chr18_21518242_21518494 0.20 LAMA3
 laminin, alpha 3
 7780
 0.21
chr12_47781967_47782118 0.20 ENSG00000264906
 .
 23990
 0.21
chr11_4111133_4111394 0.20 RRM1
 ribonucleotide reductase M1
 4776
 0.22
chr6_135339335_135339622 0.20 HBS1L
 HBS1-like (S. cerevisiae)
 8816
 0.22
chr13_42967027_42967422 0.20 AKAP11
 A kinase (PRKA) anchor protein 11
 120935
 0.06

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of PBX2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0045589 regulation of regulatory T cell differentiation(GO:0045589)
0.1 0.3 GO:0033152 immunoglobulin V(D)J recombination(GO:0033152)
0.1 0.2 GO:0002664 T cell tolerance induction(GO:0002517) regulation of T cell tolerance induction(GO:0002664) positive regulation of T cell tolerance induction(GO:0002666)
0.1 0.2 GO:0035405 histone-threonine phosphorylation(GO:0035405)
0.1 0.5 GO:0006491 N-glycan processing(GO:0006491)
0.1 0.4 GO:0007172 signal complex assembly(GO:0007172)
0.1 0.2 GO:0030187 melatonin metabolic process(GO:0030186) melatonin biosynthetic process(GO:0030187)
0.1 0.2 GO:0007100 mitotic centrosome separation(GO:0007100)
0.1 0.1 GO:0032714 negative regulation of interleukin-5 production(GO:0032714)
0.0 0.1 GO:0001778 plasma membrane repair(GO:0001778)
0.0 0.1 GO:0031580 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.0 0.1 GO:0046101 hypoxanthine biosynthetic process(GO:0046101)
0.0 0.1 GO:0043320 natural killer cell activation involved in immune response(GO:0002323) natural killer cell degranulation(GO:0043320)
0.0 0.2 GO:0007097 nuclear migration(GO:0007097)
0.0 0.1 GO:0045722 positive regulation of gluconeogenesis(GO:0045722)
0.0 0.1 GO:0006552 leucine catabolic process(GO:0006552)
0.0 0.1 GO:0006154 adenosine catabolic process(GO:0006154)
0.0 0.1 GO:0050862 positive regulation of T cell receptor signaling pathway(GO:0050862)
0.0 0.1 GO:0009448 gamma-aminobutyric acid metabolic process(GO:0009448)
0.0 0.1 GO:0006667 sphinganine metabolic process(GO:0006667)
0.0 0.1 GO:0060586 multicellular organismal iron ion homeostasis(GO:0060586)
0.0 0.1 GO:0050857 positive regulation of antigen receptor-mediated signaling pathway(GO:0050857)
0.0 0.1 GO:0046642 negative regulation of alpha-beta T cell proliferation(GO:0046642)
0.0 0.1 GO:0045341 MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343)
0.0 0.1 GO:0015959 diadenosine polyphosphate metabolic process(GO:0015959)
0.0 0.1 GO:0045603 positive regulation of endothelial cell differentiation(GO:0045603)
0.0 0.1 GO:0010216 maintenance of DNA methylation(GO:0010216)
0.0 0.3 GO:0050860 negative regulation of antigen receptor-mediated signaling pathway(GO:0050858) negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0 0.1 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.0 0.1 GO:0046015 carbon catabolite regulation of transcription(GO:0045990) regulation of transcription by glucose(GO:0046015)
0.0 0.1 GO:0006089 lactate metabolic process(GO:0006089)
0.0 0.1 GO:1901341 activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0 0.1 GO:0010956 negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137)
0.0 0.1 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.0 0.1 GO:0071698 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.0 0.1 GO:0009158 purine nucleoside monophosphate catabolic process(GO:0009128) ribonucleoside monophosphate catabolic process(GO:0009158) purine ribonucleoside monophosphate catabolic process(GO:0009169)
0.0 0.2 GO:0000132 establishment of mitotic spindle orientation(GO:0000132) establishment of spindle orientation(GO:0051294)
0.0 0.1 GO:0031061 negative regulation of histone methylation(GO:0031061)
0.0 0.1 GO:0000729 DNA double-strand break processing(GO:0000729)
0.0 0.1 GO:0006104 succinyl-CoA metabolic process(GO:0006104)
0.0 0.2 GO:2000144 positive regulation of transcription initiation from RNA polymerase II promoter(GO:0060261) positive regulation of DNA-templated transcription, initiation(GO:2000144)
0.0 0.3 GO:0043550 regulation of lipid kinase activity(GO:0043550)
0.0 0.3 GO:0030224 monocyte differentiation(GO:0030224)
0.0 0.2 GO:0006198 cAMP catabolic process(GO:0006198)
0.0 0.1 GO:0007207 phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.0 0.1 GO:0002430 complement receptor mediated signaling pathway(GO:0002430)
0.0 0.1 GO:0033632 regulation of cell-cell adhesion mediated by integrin(GO:0033632)
0.0 0.6 GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.0 0.1 GO:0060296 regulation of cilium movement(GO:0003352) regulation of cilium beat frequency(GO:0003356) cilium movement involved in cell motility(GO:0060294) regulation of cilium movement involved in cell motility(GO:0060295) regulation of cilium beat frequency involved in ciliary motility(GO:0060296) regulation of cilium-dependent cell motility(GO:1902019)
0.0 0.1 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.0 0.1 GO:0032790 ribosome disassembly(GO:0032790)
0.0 0.1 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.0 0.1 GO:0032232 negative regulation of actin filament bundle assembly(GO:0032232)
0.0 0.1 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.0 0.0 GO:0001661 conditioned taste aversion(GO:0001661)
0.0 0.0 GO:0071364 cellular response to epidermal growth factor stimulus(GO:0071364)
0.0 0.1 GO:0019673 GDP-mannose metabolic process(GO:0019673)
0.0 0.2 GO:0008105 asymmetric protein localization(GO:0008105)
0.0 0.0 GO:0002540 arachidonic acid metabolite production involved in inflammatory response(GO:0002538) leukotriene production involved in inflammatory response(GO:0002540)
0.0 0.0 GO:0002710 negative regulation of T cell mediated immunity(GO:0002710)
0.0 0.1 GO:0006498 N-terminal protein lipidation(GO:0006498)
0.0 0.0 GO:0046512 diol biosynthetic process(GO:0034312) sphingosine biosynthetic process(GO:0046512)
0.0 0.1 GO:1903429 regulation of neuron maturation(GO:0014041) regulation of cell maturation(GO:1903429)
0.0 0.2 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.0 0.1 GO:0043653 mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.0 0.1 GO:0008653 lipopolysaccharide metabolic process(GO:0008653)
0.0 0.2 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 0.1 GO:0021778 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) oligodendrocyte cell fate specification(GO:0021778) glial cell fate specification(GO:0021780)
0.0 0.1 GO:0042023 regulation of DNA endoreduplication(GO:0032875) negative regulation of DNA endoreduplication(GO:0032876) DNA endoreduplication(GO:0042023)
0.0 0.1 GO:0019987 obsolete negative regulation of anti-apoptosis(GO:0019987)
0.0 0.0 GO:0072217 negative regulation of metanephros development(GO:0072217)
0.0 0.1 GO:0035751 lysosomal lumen acidification(GO:0007042) regulation of lysosomal lumen pH(GO:0035751)
0.0 0.1 GO:0018076 N-terminal peptidyl-lysine acetylation(GO:0018076)
0.0 0.1 GO:0006855 drug transmembrane transport(GO:0006855)
0.0 0.1 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0 0.1 GO:0008340 determination of adult lifespan(GO:0008340)
0.0 0.1 GO:0006422 aspartyl-tRNA aminoacylation(GO:0006422)
0.0 0.1 GO:0060710 chorio-allantoic fusion(GO:0060710)
0.0 0.1 GO:0042921 glucocorticoid receptor signaling pathway(GO:0042921)
0.0 0.1 GO:0051970 negative regulation of transmission of nerve impulse(GO:0051970)
0.0 0.2 GO:0016180 snRNA processing(GO:0016180)
0.0 0.1 GO:0016576 histone dephosphorylation(GO:0016576)
0.0 0.0 GO:0002248 connective tissue replacement involved in inflammatory response wound healing(GO:0002248) connective tissue replacement(GO:0097709)
0.0 0.0 GO:0007571 age-dependent response to oxidative stress(GO:0001306) age-dependent general metabolic decline(GO:0007571)
0.0 0.1 GO:0006474 N-terminal protein amino acid acetylation(GO:0006474)
0.0 0.1 GO:0003056 regulation of vascular smooth muscle contraction(GO:0003056)
0.0 0.0 GO:0034625 fatty acid elongation, monounsaturated fatty acid(GO:0034625)
0.0 0.1 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 0.4 GO:0050690 regulation of defense response to virus by virus(GO:0050690)
0.0 0.1 GO:0060023 soft palate development(GO:0060023)
0.0 0.1 GO:0019885 antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.0 0.1 GO:0032693 negative regulation of interleukin-10 production(GO:0032693)
0.0 0.0 GO:0060433 bronchus development(GO:0060433)
0.0 0.1 GO:0035092 sperm chromatin condensation(GO:0035092)
0.0 0.1 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.0 0.1 GO:0010457 centriole-centriole cohesion(GO:0010457)
0.0 0.1 GO:0032455 nerve growth factor processing(GO:0032455)
0.0 0.0 GO:0022009 establishment of endothelial blood-brain barrier(GO:0014045) central nervous system vasculogenesis(GO:0022009)
0.0 0.1 GO:0046831 regulation of RNA export from nucleus(GO:0046831)
0.0 0.1 GO:0032878 regulation of establishment or maintenance of cell polarity(GO:0032878)
0.0 0.1 GO:0043628 ncRNA 3'-end processing(GO:0043628)
0.0 0.2 GO:0034199 activation of protein kinase A activity(GO:0034199)
0.0 0.0 GO:0061154 endothelial tube morphogenesis(GO:0061154)
0.0 0.0 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.0 0.0 GO:0090005 negative regulation of establishment of protein localization to plasma membrane(GO:0090005) negative regulation of protein localization to plasma membrane(GO:1903077) negative regulation of protein localization to cell periphery(GO:1904376)
0.0 0.0 GO:0003161 cardiac conduction system development(GO:0003161)
0.0 0.1 GO:0032753 positive regulation of interleukin-4 production(GO:0032753)
0.0 0.1 GO:0071157 negative regulation of cell cycle arrest(GO:0071157)
0.0 0.1 GO:0060292 long term synaptic depression(GO:0060292)
0.0 0.0 GO:0010586 miRNA metabolic process(GO:0010586) miRNA catabolic process(GO:0010587)
0.0 0.1 GO:0046655 folic acid metabolic process(GO:0046655)
0.0 0.0 GO:0002313 mature B cell differentiation involved in immune response(GO:0002313)
0.0 0.2 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
0.0 0.0 GO:0043374 CD8-positive, alpha-beta T cell activation(GO:0036037) CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0 0.1 GO:0060158 phospholipase C-activating dopamine receptor signaling pathway(GO:0060158)
0.0 0.0 GO:0034720 histone H3-K4 demethylation(GO:0034720)
0.0 0.1 GO:0002138 retinoic acid biosynthetic process(GO:0002138) diterpenoid biosynthetic process(GO:0016102)
0.0 0.0 GO:0070672 response to interleukin-15(GO:0070672)
0.0 0.1 GO:0007256 activation of JNKK activity(GO:0007256)
0.0 0.0 GO:0042726 flavin-containing compound metabolic process(GO:0042726)
0.0 0.0 GO:0008054 negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation(GO:0008054)
0.0 0.0 GO:0006772 thiamine metabolic process(GO:0006772)
0.0 0.0 GO:0031442 positive regulation of mRNA 3'-end processing(GO:0031442) positive regulation of mRNA processing(GO:0050685) positive regulation of mRNA metabolic process(GO:1903313)
0.0 0.0 GO:0070230 positive regulation of lymphocyte apoptotic process(GO:0070230)
0.0 0.0 GO:0034139 regulation of toll-like receptor 3 signaling pathway(GO:0034139)
0.0 0.0 GO:0019852 L-ascorbic acid metabolic process(GO:0019852)
0.0 0.6 GO:0050852 T cell receptor signaling pathway(GO:0050852)
0.0 0.0 GO:0010572 positive regulation of platelet activation(GO:0010572)
0.0 0.1 GO:0042989 sequestering of actin monomers(GO:0042989)
0.0 0.0 GO:0019731 antibacterial humoral response(GO:0019731)
0.0 0.0 GO:0002032 desensitization of G-protein coupled receptor protein signaling pathway by arrestin(GO:0002032)
0.0 0.0 GO:0009756 carbohydrate mediated signaling(GO:0009756)
0.0 0.1 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.0 0.0 GO:0070272 proton-transporting ATP synthase complex assembly(GO:0043461) proton-transporting ATP synthase complex biogenesis(GO:0070272)
0.0 0.0 GO:0060298 positive regulation of sarcomere organization(GO:0060298)
0.0 0.0 GO:0032070 regulation of deoxyribonuclease activity(GO:0032070)
0.0 0.0 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0 0.0 GO:0032673 interleukin-4 production(GO:0032633) regulation of interleukin-4 production(GO:0032673)
0.0 0.0 GO:0042339 keratan sulfate metabolic process(GO:0042339)
0.0 0.0 GO:0046607 positive regulation of centrosome cycle(GO:0046607)
0.0 0.0 GO:0045542 positive regulation of cholesterol biosynthetic process(GO:0045542)
0.0 0.0 GO:0019805 quinolinate biosynthetic process(GO:0019805)
0.0 0.0 GO:0006922 obsolete cleavage of lamin involved in execution phase of apoptosis(GO:0006922)
0.0 0.0 GO:0035066 positive regulation of histone acetylation(GO:0035066) positive regulation of protein acetylation(GO:1901985) positive regulation of peptidyl-lysine acetylation(GO:2000758)
0.0 0.1 GO:0060438 trachea development(GO:0060438)
0.0 0.0 GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518) negative regulation of signal transduction by p53 class mediator(GO:1901797)
0.0 0.0 GO:0071459 protein localization to kinetochore(GO:0034501) protein localization to chromosome, centromeric region(GO:0071459)
0.0 0.0 GO:0043931 ossification involved in bone maturation(GO:0043931)
0.0 0.0 GO:0034145 positive regulation of toll-like receptor 4 signaling pathway(GO:0034145)
0.0 0.0 GO:0045059 positive thymic T cell selection(GO:0045059)
0.0 0.0 GO:0045793 positive regulation of cell size(GO:0045793)
0.0 0.3 GO:0006305 DNA alkylation(GO:0006305) DNA methylation(GO:0006306)
0.0 0.1 GO:0007096 regulation of exit from mitosis(GO:0007096)
0.0 0.1 GO:0043984 histone H4-K16 acetylation(GO:0043984)
0.0 0.0 GO:0019276 UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.0 0.0 GO:0048742 regulation of skeletal muscle fiber development(GO:0048742)
0.0 0.0 GO:0072193 positive regulation of smooth muscle cell differentiation(GO:0051152) ureter smooth muscle development(GO:0072191) ureter smooth muscle cell differentiation(GO:0072193)
0.0 0.1 GO:0006658 phosphatidylserine metabolic process(GO:0006658)
0.0 0.1 GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress(GO:0070059)
0.0 0.0 GO:0002523 leukocyte migration involved in inflammatory response(GO:0002523)
0.0 0.1 GO:0009812 flavonoid metabolic process(GO:0009812)
0.0 0.0 GO:0009301 snRNA transcription(GO:0009301)
0.0 0.1 GO:0022027 interkinetic nuclear migration(GO:0022027)
0.0 0.0 GO:0030202 heparin metabolic process(GO:0030202)
0.0 0.0 GO:0002282 microglial cell activation involved in immune response(GO:0002282)
0.0 0.0 GO:0019509 L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
0.0 0.1 GO:0002839 regulation of response to tumor cell(GO:0002834) positive regulation of response to tumor cell(GO:0002836) regulation of immune response to tumor cell(GO:0002837) positive regulation of immune response to tumor cell(GO:0002839)
0.0 0.0 GO:0042415 norepinephrine metabolic process(GO:0042415)
0.0 0.0 GO:0009214 cyclic nucleotide catabolic process(GO:0009214)
0.0 0.1 GO:0008635 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c(GO:0008635)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0000942 condensed nuclear chromosome outer kinetochore(GO:0000942)
0.0 0.1 GO:0031313 extrinsic component of vacuolar membrane(GO:0000306) extrinsic component of endosome membrane(GO:0031313)
0.0 0.1 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0 0.3 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.1 GO:0071001 U4/U6 snRNP(GO:0071001)
0.0 0.1 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.0 0.1 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 0.2 GO:0070688 MLL5-L complex(GO:0070688)
0.0 0.1 GO:0031371 ubiquitin conjugating enzyme complex(GO:0031371)
0.0 0.1 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.1 GO:0071778 obsolete WINAC complex(GO:0071778)
0.0 0.0 GO:0033270 paranode region of axon(GO:0033270)
0.0 0.1 GO:0002178 palmitoyltransferase complex(GO:0002178) serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0 0.1 GO:0005826 actomyosin contractile ring(GO:0005826)
0.0 0.2 GO:0032039 integrator complex(GO:0032039)
0.0 0.1 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 0.1 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 0.4 GO:0005871 kinesin complex(GO:0005871)
0.0 0.1 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
0.0 0.1 GO:0031088 platelet dense granule membrane(GO:0031088)
0.0 0.1 GO:0072487 MSL complex(GO:0072487)
0.0 0.3 GO:0030530 obsolete heterogeneous nuclear ribonucleoprotein complex(GO:0030530)
0.0 0.2 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.1 GO:0042101 T cell receptor complex(GO:0042101)
0.0 0.1 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 0.1 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.0 0.0 GO:0071986 Ragulator complex(GO:0071986)
0.0 0.1 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.0 0.1 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 0.1 GO:0005827 polar microtubule(GO:0005827)
0.0 0.0 GO:0045298 tubulin complex(GO:0045298)
0.0 0.1 GO:0097425 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.0 0.2 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 0.1 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 0.1 GO:0001740 Barr body(GO:0001740)
0.0 0.1 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.1 GO:0005797 Golgi medial cisterna(GO:0005797)
0.0 0.2 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.0 0.1 GO:0005838 proteasome regulatory particle(GO:0005838)
0.0 0.2 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.0 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.0 0.1 GO:0000242 pericentriolar material(GO:0000242)
0.0 0.1 GO:0001772 immunological synapse(GO:0001772)
0.0 0.1 GO:0042589 zymogen granule membrane(GO:0042589)
0.0 0.1 GO:0005678 obsolete chromatin assembly complex(GO:0005678)
0.0 0.1 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.0 0.1 GO:0016471 vacuolar proton-transporting V-type ATPase complex(GO:0016471)
0.0 0.0 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.0 0.1 GO:0034362 low-density lipoprotein particle(GO:0034362)
0.0 0.0 GO:0005588 collagen type V trimer(GO:0005588)
0.0 0.2 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.0 0.0 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.1 0.2 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.1 0.2 GO:0035184 histone threonine kinase activity(GO:0035184)
0.1 0.2 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.0 0.1 GO:0004465 lipoprotein lipase activity(GO:0004465)
0.0 0.1 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0 0.2 GO:0034190 apolipoprotein receptor binding(GO:0034190)
0.0 0.1 GO:0001758 retinal dehydrogenase activity(GO:0001758)
0.0 0.1 GO:0047623 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0 0.1 GO:0016509 long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0016509)
0.0 0.5 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.0 0.2 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.2 GO:0031013 troponin I binding(GO:0031013)
0.0 0.2 GO:0016494 C-X-C chemokine receptor activity(GO:0016494)
0.0 0.1 GO:0004062 aryl sulfotransferase activity(GO:0004062)
0.0 0.1 GO:0043024 ribosomal small subunit binding(GO:0043024)
0.0 0.1 GO:0042608 T cell receptor binding(GO:0042608)
0.0 0.1 GO:0016454 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0 0.1 GO:0016886 ligase activity, forming phosphoric ester bonds(GO:0016886)
0.0 0.1 GO:0008486 diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486)
0.0 0.1 GO:0015226 amino-acid betaine transmembrane transporter activity(GO:0015199) carnitine transmembrane transporter activity(GO:0015226)
0.0 0.1 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0 0.2 GO:0008266 poly(U) RNA binding(GO:0008266)
0.0 0.1 GO:0004774 succinate-CoA ligase activity(GO:0004774)
0.0 0.1 GO:0098599 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 0.1 GO:0052813 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.0 0.1 GO:0030284 estrogen receptor activity(GO:0030284)
0.0 0.1 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.0 0.1 GO:0050544 arachidonic acid binding(GO:0050544)
0.0 0.1 GO:0000400 four-way junction DNA binding(GO:0000400)
0.0 0.2 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0 0.1 GO:0004875 complement receptor activity(GO:0004875)
0.0 0.1 GO:0043141 ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.0 0.1 GO:0070087 chromo shadow domain binding(GO:0070087)
0.0 0.1 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.1 GO:0070097 delta-catenin binding(GO:0070097)
0.0 0.1 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.0 0.1 GO:0031434 mitogen-activated protein kinase kinase binding(GO:0031434)
0.0 0.1 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 0.1 GO:0008172 S-methyltransferase activity(GO:0008172)
0.0 0.1 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0 0.1 GO:0003953 NAD+ nucleosidase activity(GO:0003953)
0.0 0.1 GO:0016778 diphosphotransferase activity(GO:0016778)
0.0 0.1 GO:0003829 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0003829)
0.0 0.1 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.0 0.1 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.3 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.0 0.2 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity(GO:0034593)
0.0 0.1 GO:0070568 guanylyltransferase activity(GO:0070568)
0.0 0.1 GO:0045569 TRAIL binding(GO:0045569)
0.0 0.1 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.0 0.1 GO:0008900 hydrogen:potassium-exchanging ATPase activity(GO:0008900)
0.0 0.1 GO:0034713 type I transforming growth factor beta receptor binding(GO:0034713)
0.0 0.1 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 0.1 GO:0048156 tau protein binding(GO:0048156)
0.0 0.1 GO:0033691 sialic acid binding(GO:0033691)
0.0 0.1 GO:0047756 chondroitin 4-sulfotransferase activity(GO:0047756)
0.0 0.1 GO:0000247 C-8 sterol isomerase activity(GO:0000247)
0.0 0.1 GO:0034452 dynactin binding(GO:0034452)
0.0 0.1 GO:0004815 aspartate-tRNA ligase activity(GO:0004815)
0.0 0.1 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.0 0.2 GO:0008536 Ran GTPase binding(GO:0008536)
0.0 0.0 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.0 0.1 GO:0000977 transcription regulatory region sequence-specific DNA binding(GO:0000976) RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977) RNA polymerase II regulatory region DNA binding(GO:0001012)
0.0 0.2 GO:0004697 protein kinase C activity(GO:0004697)
0.0 0.0 GO:0032137 guanine/thymine mispair binding(GO:0032137)
0.0 0.1 GO:0004689 phosphorylase kinase activity(GO:0004689)
0.0 0.1 GO:0031685 adenosine receptor binding(GO:0031685)
0.0 0.0 GO:0035198 miRNA binding(GO:0035198)
0.0 0.1 GO:0008409 5'-3' exonuclease activity(GO:0008409)
0.0 0.1 GO:0004576 oligosaccharyl transferase activity(GO:0004576)
0.0 0.2 GO:0008373 sialyltransferase activity(GO:0008373)
0.0 0.1 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.0 0.0 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 0.1 GO:0016934 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.0 0.2 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.1 GO:0043560 insulin receptor substrate binding(GO:0043560)
0.0 0.1 GO:0050733 RS domain binding(GO:0050733)
0.0 0.1 GO:0005131 growth hormone receptor binding(GO:0005131)
0.0 0.1 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 0.3 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 0.1 GO:0016595 glutamate binding(GO:0016595)
0.0 0.0 GO:0032139 dinucleotide insertion or deletion binding(GO:0032139)
0.0 0.1 GO:0000828 inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832)
0.0 0.1 GO:0004017 adenylate kinase activity(GO:0004017)
0.0 0.1 GO:0017091 AU-rich element binding(GO:0017091)
0.0 0.2 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 0.0 GO:0036002 pre-mRNA binding(GO:0036002)
0.0 0.1 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.1 GO:0030275 LRR domain binding(GO:0030275)
0.0 0.0 GO:0045499 chemorepellent activity(GO:0045499)
0.0 0.0 GO:0004939 beta-adrenergic receptor activity(GO:0004939)
0.0 0.1 GO:0005522 profilin binding(GO:0005522)
0.0 0.2 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 0.0 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.0 0.2 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.0 GO:0000064 L-ornithine transmembrane transporter activity(GO:0000064)
0.0 0.2 GO:0001608 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.2 GO:0016505 peptidase activator activity involved in apoptotic process(GO:0016505)
0.0 0.1 GO:0015924 mannosyl-oligosaccharide mannosidase activity(GO:0015924)
0.0 0.1 GO:0016493 C-C chemokine receptor activity(GO:0016493)
0.0 0.0 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0 0.6 GO:0008301 DNA binding, bending(GO:0008301)
0.0 0.0 GO:0004911 interleukin-2 receptor activity(GO:0004911)
0.0 0.2 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.1 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.0 0.1 GO:0005138 interleukin-6 receptor binding(GO:0005138)
0.0 0.2 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.2 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.0 0.1 GO:0031593 polyubiquitin binding(GO:0031593)
0.0 0.1 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.0 0.0 GO:0043398 HLH domain binding(GO:0043398)
0.0 0.0 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 0.3 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.6 PID REELIN PATHWAY Reelin signaling pathway
0.0 0.9 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 0.0 PID IL5 PATHWAY IL5-mediated signaling events
0.0 0.0 ST GRANULE CELL SURVIVAL PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.0 0.1 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 0.3 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.0 0.5 PID PI3KCI PATHWAY Class I PI3K signaling events
0.0 0.2 PID AVB3 OPN PATHWAY Osteopontin-mediated events
0.0 0.4 PID HIV NEF PATHWAY HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.0 0.3 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events
0.0 0.1 ST INTERLEUKIN 4 PATHWAY Interleukin 4 (IL-4) Pathway
0.0 0.5 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.0 0.2 PID GMCSF PATHWAY GMCSF-mediated signaling events
0.0 0.1 ST GAQ PATHWAY G alpha q Pathway
0.0 0.1 PID TRAIL PATHWAY TRAIL signaling pathway
0.0 0.1 PID CXCR3 PATHWAY CXCR3-mediated signaling events
0.0 0.0 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions
0.0 0.3 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 0.4 PID NFAT 3PATHWAY Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.0 0.0 ST G ALPHA S PATHWAY G alpha s Pathway
0.0 0.3 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 0.0 PID S1P S1P4 PATHWAY S1P4 pathway
0.0 0.1 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.0 0.1 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.0 0.1 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.2 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.0 0.1 ST IL 13 PATHWAY Interleukin 13 (IL-13) Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.0 0.4 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.0 0.3 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 0.0 REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 Genes involved in Autodegradation of the E3 ubiquitin ligase COP1
0.0 0.4 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0 0.2 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 0.4 REACTOME CTLA4 INHIBITORY SIGNALING Genes involved in CTLA4 inhibitory signaling
0.0 0.1 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
0.0 0.2 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0 0.4 REACTOME DOWNSTREAM TCR SIGNALING Genes involved in Downstream TCR signaling
0.0 0.2 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.2 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.0 0.3 REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB Genes involved in PKA-mediated phosphorylation of CREB
0.0 0.0 REACTOME SPRY REGULATION OF FGF SIGNALING Genes involved in Spry regulation of FGF signaling
0.0 0.0 REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0 0.1 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0 0.0 REACTOME PHOSPHORYLATION OF THE APC C Genes involved in Phosphorylation of the APC/C
0.0 0.2 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0 0.0 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.0 0.2 REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.0 0.2 REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.0 0.1 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.0 0.2 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.2 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.2 REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0 0.1 REACTOME GPVI MEDIATED ACTIVATION CASCADE Genes involved in GPVI-mediated activation cascade
0.0 0.2 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 0.1 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 0.0 REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.0 0.0 REACTOME NRIF SIGNALS CELL DEATH FROM THE NUCLEUS Genes involved in NRIF signals cell death from the nucleus
0.0 0.1 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.0 0.0 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.0 0.1 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling