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ENCODE: H3K4me1 ChIP-Seq of primary human cells
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Results for PBX3

Z-value: 1.50

Motif logo

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Transcription factors associated with PBX3

Gene Symbol Gene ID Gene Info
PBX3
ENSG00000167081.12 PBX homeobox 3

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr9_128507553_128507704PBX319960.422825-0.781.4e-02Click!
chr9_128569217_128569368PBX3582580.151053-0.771.5e-02Click!
chr9_128569608_128569759PBX3578670.152131-0.761.8e-02Click!
chr9_128507309_128507460PBX322400.394795-0.742.3e-02Click!
chr9_128586556_128586874PBX3408350.2051340.742.4e-02Click!

Activity of the PBX3 motif across conditions

Conditions sorted by the z-value of the PBX3 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr12_46612081_46612340 0.66 SLC38A1
 solute carrier family 38, member 1
 49274
 0.18
chr19_16478953_16479699 0.62 EPS15L1
 epidermal growth factor receptor pathway substrate 15-like 1
 6562
 0.16
chr12_132089385_132089651 0.48 ENSG00000212154
 .
 56090
 0.15
chr1_231749795_231749989 0.46 LINC00582
 long intergenic non-protein coding RNA 582
 2056
 0.33
chr1_209923175_209923334 0.40 TRAF3IP3
 TRAF3 interacting protein 3
 6123
 0.15
chr17_4407370_4407845 0.39 AC118754.4
4638
 0.14
chr21_46337383_46337695 0.38 ITGB2
 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
 3231
 0.13
chr9_117152080_117152353 0.38 AKNA
 AT-hook transcription factor
 1855
 0.37
chr5_156698267_156698699 0.37 CYFIP2
 cytoplasmic FMR1 interacting protein 2
 2121
 0.24
chr5_177665749_177666095 0.36 PHYKPL
 5-phosphohydroxy-L-lysine phospho-lyase
 6136
 0.21
chr19_7401594_7401745 0.36 CTB-133G6.1
12179
 0.16
chr18_74765525_74765769 0.35 MBP
 myelin basic protein
 35913
 0.2
chr22_37255941_37256092 0.35 NCF4
 neutrophil cytosolic factor 4, 40kDa
 1014
 0.44
chr1_226085113_226085288 0.35 LEFTY1
 left-right determination factor 1
 8354
 0.12
chr15_31657045_31657355 0.34 KLF13
 Kruppel-like factor 13
 1157
 0.65
chr3_13459136_13459287 0.34 NUP210
 nucleoporin 210kDa
 2598
 0.34
chr8_27223358_27224128 0.34 PTK2B
 protein tyrosine kinase 2 beta
 14425
 0.22
chr1_108383656_108383813 0.33 ENSG00000265536
 .
 64856
 0.13
chr14_91831572_91831792 0.33 ENSG00000265856
 .
 31625
 0.18
chr14_91882380_91882531 0.33 CCDC88C
 coiled-coil domain containing 88C
 1235
 0.55
chr10_74089130_74089540 0.33 DNAJB12
 DnaJ (Hsp40) homolog, subfamily B, member 12
 15384
 0.18
chr15_65185093_65185446 0.33 ENSG00000264929
 .
 7169
 0.15
chr16_68112832_68113115 0.32 NFATC3
 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
 6274
 0.11
chr11_68597072_68597223 0.32 CPT1A
 carnitine palmitoyltransferase 1A (liver)
 10005
 0.2
chr12_42983182_42983333 0.31 PRICKLE1
 prickle homolog 1 (Drosophila)
 221
 0.96
chr1_247554015_247554170 0.31 NLRP3
 NLR family, pyrin domain containing 3
 25366
 0.15
chr4_36287491_36287642 0.31 DTHD1
 death domain containing 1
 1922
 0.38
chr20_44988074_44988423 0.31 SLC35C2
 solute carrier family 35 (GDP-fucose transporter), member C2
 845
 0.63
chr2_74432429_74432593 0.31 MTHFD2
 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
 6768
 0.14
chr19_1854678_1854886 0.31 CTB-31O20.6
2384
 0.13
chr2_68970790_68970944 0.30 ARHGAP25
 Rho GTPase activating protein 25
 8853
 0.26
chr15_69084791_69085147 0.30 ENSG00000265195
 .
 9295
 0.23
chr13_95837690_95837898 0.30 ENSG00000238463
 .
 24804
 0.24
chr6_53202509_53202860 0.30 ELOVL5
 ELOVL fatty acid elongase 5
 10903
 0.21
chr6_37470020_37470409 0.30 CCDC167
 coiled-coil domain containing 167
 2516
 0.3
chrX_19818791_19819076 0.29 SH3KBP1
 SH3-domain kinase binding protein 1
 1064
 0.67
chr2_43402387_43402951 0.29 ZFP36L2
 ZFP36 ring finger protein-like 2
 51079
 0.14
chr7_102072492_102072712 0.29 ORAI2
 ORAI calcium release-activated calcium modulator 2
 951
 0.34
chr2_191934456_191934744 0.29 ENSG00000231858
 .
 48348
 0.11
chr9_92096499_92096783 0.29 SEMA4D
 sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
 1836
 0.41
chr20_20714651_20715009 0.29 ENSG00000264361
 .
 4544
 0.29
chr1_207307763_207307914 0.29 C4BPA
 complement component 4 binding protein, alpha
 30187
 0.15
chr19_50083532_50083683 0.29 NOSIP
 nitric oxide synthase interacting protein
 196
 0.58
chr12_56536054_56536223 0.29 MYL6B
 myosin, light chain 6B, alkali, smooth muscle and non-muscle
 9902
 0.06
chr16_21519012_21519163 0.29 ENSG00000265462
 .
 1631
 0.33
chr9_134466441_134466779 0.29 RAPGEF1
 Rap guanine nucleotide exchange factor (GEF) 1
 30615
 0.15
chr10_73454547_73455031 0.29 C10orf105
 chromosome 10 open reading frame 105
 24789
 0.19
chr15_67359185_67359373 0.28 SMAD3
 SMAD family member 3
 1096
 0.64
chr11_121290717_121290893 0.28 SORL1
 sortilin-related receptor, L(DLR class) A repeats containing
 32107
 0.2
chr22_37256493_37256696 0.28 NCF4
 neutrophil cytosolic factor 4, 40kDa
 436
 0.77
chr16_23846812_23846963 0.28 PRKCB
 protein kinase C, beta
 435
 0.87
chr15_81585979_81586156 0.28 IL16
 interleukin 16
 3187
 0.26
chr8_48512256_48512407 0.28 SPIDR
 scaffolding protein involved in DNA repair
 59895
 0.12
chr19_47947885_47948253 0.28 MEIS3
 Meis homeobox 3
 25289
 0.11
chr7_150148399_150148619 0.28 GIMAP8
 GTPase, IMAP family member 8
 791
 0.61
chr7_950255_950436 0.28 ADAP1
 ArfGAP with dual PH domains 1
 5631
 0.16
chr7_106102687_106102838 0.28 CTB-111H14.1
42523
 0.2
chrX_71327974_71328129 0.27 RGAG4
 retrotransposon gag domain containing 4
 23627
 0.15
chr3_185868368_185868519 0.27 ETV5
 ets variant 5
 40336
 0.17
chr15_70011296_70011552 0.27 ENSG00000238870
 .
 11737
 0.27
chr1_112059890_112060120 0.27 ADORA3
 adenosine A3 receptor
 13623
 0.12
chr10_17272231_17272382 0.27 VIM
 vimentin
 302
 0.5
chr21_34674475_34674626 0.27 IFNAR1
 interferon (alpha, beta and omega) receptor 1
 22184
 0.14
chr21_47012341_47012492 0.27 SLC19A1
 solute carrier family 19 (folate transporter), member 1
 48091
 0.13
chr1_226869309_226869761 0.27 ITPKB-IT1
 ITPKB intronic transcript 1 (non-protein coding)
 6767
 0.22
chr16_23849905_23850213 0.27 PRKCB
 protein kinase C, beta
 1515
 0.48
chr6_33882010_33882240 0.27 ENSG00000221697
 .
 85703
 0.07
chr5_75679885_75680036 0.26 IQGAP2
 IQ motif containing GTPase activating protein 2
 19114
 0.25
chr8_8937758_8938041 0.26 ENSG00000239078
 .
 7873
 0.16
chr19_45673972_45674161 0.26 TRAPPC6A
 trafficking protein particle complex 6A
 7419
 0.1
chr7_150284241_150284504 0.26 GIMAP4
 GTPase, IMAP family member 4
 19848
 0.17
chr12_89637392_89637703 0.26 ENSG00000238302
 .
 38515
 0.21
chr9_95875174_95875472 0.26 C9orf89
 chromosome 9 open reading frame 89
 16823
 0.14
chr5_148229367_148229546 0.26 ADRB2
 adrenoceptor beta 2, surface
 23300
 0.23
chr19_23578327_23578478 0.26 ZNF91
 zinc finger protein 91
 40
 0.99
chr2_220075170_220075321 0.26 ZFAND2B
 zinc finger, AN1-type domain 2B
 2065
 0.13
chr19_51614835_51615109 0.26 CTU1
 cytosolic thiouridylase subunit 1
 3345
 0.12
chr7_5764788_5764939 0.26 RNF216-IT1
 RNF216 intronic transcript 1 (non-protein coding)
 44771
 0.12
chr6_53158531_53158728 0.26 ENSG00000264056
 .
 16838
 0.19
chr8_56887355_56887506 0.26 ENSG00000240905
 .
 5666
 0.17
chr17_76128893_76129294 0.26 TMC6
 transmembrane channel-like 6
 605
 0.58
chr7_142393843_142394165 0.26 MTRNR2L6
 MT-RNR2-like 6
 19900
 0.21
chr8_91027854_91028058 0.26 DECR1
 2,4-dienoyl CoA reductase 1, mitochondrial
 14211
 0.21
chr22_30383223_30383521 0.26 MTMR3
 myotubularin related protein 3
 16332
 0.18
chr2_143899228_143899449 0.26 ARHGAP15
 Rho GTPase activating protein 15
 12455
 0.25
chr15_93423599_93423785 0.25 CHD2
 chromodomain helicase DNA binding protein 2
 2834
 0.25
chr22_23180915_23181197 0.25 IGLV3-7
 immunoglobulin lambda variable 3-7 (pseudogene)
 277
 0.69
chrX_49144105_49144462 0.25 PPP1R3F
 protein phosphatase 1, regulatory subunit 3F
 7044
 0.09
chr7_50359446_50359660 0.25 IKZF1
 IKAROS family zinc finger 1 (Ikaros)
 7692
 0.3
chr2_28600951_28601321 0.25 FOSL2
 FOS-like antigen 2
 14533
 0.17
chr6_37891842_37892090 0.25 ZFAND3
 zinc finger, AN1-type domain 3
 5769
 0.23
chr4_124343671_124343822 0.25 SPRY1
 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
 22623
 0.29
chr6_53209989_53210148 0.25 ELOVL5
 ELOVL fatty acid elongase 5
 3519
 0.27
chr6_24938013_24938250 0.25 FAM65B
 family with sequence similarity 65, member B
 1943
 0.4
chr1_65528662_65528934 0.25 ENSG00000199135
 .
 4607
 0.21
chr7_158333894_158334080 0.25 PTPRN2
 protein tyrosine phosphatase, receptor type, N polypeptide 2
 311
 0.87
chr11_128437008_128437281 0.25 ETS1
 v-ets avian erythroblastosis virus E26 oncogene homolog 1
 20309
 0.22
chr10_82286341_82286627 0.25 RP11-137H2.4
9214
 0.21
chr16_3264680_3265035 0.25 OR1F1
 olfactory receptor, family 1, subfamily F, member 1
 10610
 0.1
chr4_153556216_153556367 0.25 RP11-768B22.2
31229
 0.17
chr10_7301599_7302058 0.24 SFMBT2
 Scm-like with four mbt domains 2
 148879
 0.05
chr9_36143442_36143697 0.24 GLIPR2
 GLI pathogenesis-related 2
 6827
 0.19
chr11_970627_970916 0.24 ENSG00000264671
 .
 19407
 0.11
chr1_169572674_169572971 0.24 SELP
 selectin P (granule membrane protein 140kDa, antigen CD62)
 15635
 0.19
chr2_198160878_198161163 0.24 ANKRD44-IT1
 ANKRD44 intronic transcript 1 (non-protein coding)
 6223
 0.18
chr14_65196780_65197075 0.24 PLEKHG3
 pleckstrin homology domain containing, family G (with RhoGef domain) member 3
 6428
 0.23
chr2_99090936_99091099 0.24 INPP4A
 inositol polyphosphate-4-phosphatase, type I, 107kDa
 29604
 0.2
chr11_62375084_62375469 0.24 RP11-831H9.3
1643
 0.14
chr12_108943808_108943959 0.24 SART3
 squamous cell carcinoma antigen recognized by T cells 3
 779
 0.58
chr22_36845283_36845515 0.24 ENSG00000252225
 .
 8384
 0.15
chr16_57637288_57637569 0.24 GPR56
 G protein-coupled receptor 56
 7136
 0.16
chr11_118334021_118334172 0.24 KMT2A
 lysine (K)-specific methyltransferase 2A
 18450
 0.1
chr11_3970595_3970888 0.24 STIM1
 stromal interaction molecule 1
 2168
 0.29
chr3_46283606_46283757 0.24 CCR3
 chemokine (C-C motif) receptor 3
 191
 0.95
chrX_39632433_39632734 0.24 ENSG00000264618
 .
 13494
 0.27
chr12_94598358_94598823 0.24 RP11-74K11.2
18770
 0.19
chr2_70702817_70703084 0.24 TGFA-IT1
 TGFA intronic transcript 1 (non-protein coding)
 7323
 0.17
chr10_11185783_11186046 0.24 CELF2
 CUGBP, Elav-like family member 2
 21079
 0.19
chr14_93124009_93124262 0.24 RIN3
 Ras and Rab interactor 3
 5289
 0.29
chr7_128709355_128709605 0.24 ENSG00000238733
 .
 7895
 0.17
chr4_113210653_113210866 0.24 TIFA
 TRAF-interacting protein with forkhead-associated domain
 3700
 0.19
chr4_25856242_25856535 0.24 SEL1L3
 sel-1 suppressor of lin-12-like 3 (C. elegans)
 5865
 0.28
chr5_75838190_75838590 0.24 IQGAP2
 IQ motif containing GTPase activating protein 2
 4844
 0.28
chr14_99720519_99720759 0.23 AL109767.1
8646
 0.22
chr22_40739144_40739395 0.23 ADSL
 adenylosuccinate lyase
 3238
 0.24
chr12_55362221_55362689 0.23 TESPA1
 thymocyte expressed, positive selection associated 1
 4883
 0.26
chr6_157204713_157204928 0.23 ARID1B
 AT rich interactive domain 1B (SWI1-like)
 17687
 0.27
chr21_32549988_32550321 0.23 TIAM1
 T-cell lymphoma invasion and metastasis 1
 47615
 0.18
chr1_101700535_101700730 0.23 RP4-575N6.4
1452
 0.31
chr1_100889654_100889805 0.23 ENSG00000216067
 .
 45398
 0.13
chr20_47489423_47489788 0.23 PREX1
 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
 45185
 0.16
chr14_93055044_93055462 0.23 RIN3
 Ras and Rab interactor 3
 63593
 0.13
chr6_116990241_116990392 0.23 ZUFSP
 zinc finger with UFM1-specific peptidase domain
 359
 0.86
chr2_113873143_113873294 0.23 IL1RN
 interleukin 1 receptor antagonist
 2252
 0.23
chr17_61741988_61742139 0.23 LIMD2
 LIM domain containing 2
 34459
 0.11
chr17_40827802_40827953 0.23 PLEKHH3
 pleckstrin homology domain containing, family H (with MyTH4 domain) member 3
 1092
 0.28
chr1_936801_936952 0.23 HES4
 hes family bHLH transcription factor 4
 1324
 0.24
chr8_92077318_92077469 0.23 GS1-251I9.4
4958
 0.14
chr1_247171443_247171594 0.23 ZNF695
 zinc finger protein 695
 123
 0.97
chr9_102353038_102353189 0.23 NR4A3
 nuclear receptor subfamily 4, group A, member 3
 231024
 0.02
chr16_30915219_30915595 0.23 CTF1
 cardiotrophin 1
 7448
 0.08
chr2_113944916_113945243 0.23 PSD4
 pleckstrin and Sec7 domain containing 4
 8778
 0.14
chr5_118660068_118660353 0.23 TNFAIP8
 tumor necrosis factor, alpha-induced protein 8
 8660
 0.2
chr1_27659481_27659659 0.23 ENSG00000206888
 .
 7860
 0.12
chr4_40725932_40726083 0.23 NSUN7
 NOP2/Sun domain family, member 7
 25907
 0.2
chr19_6710761_6710951 0.23 C3
 complement component 3
 9837
 0.12
chr4_16214348_16214631 0.23 TAPT1
 transmembrane anterior posterior transformation 1
 13605
 0.19
chr12_109019257_109019703 0.23 RP11-689B22.2
2983
 0.18
chr1_31223327_31223571 0.23 LAPTM5
 lysosomal protein transmembrane 5
 7218
 0.16
chr14_91834332_91834534 0.23 ENSG00000265856
 .
 34376
 0.17
chr3_47000825_47001095 0.23 CCDC12
 coiled-coil domain containing 12
 17310
 0.15
chr12_19638734_19639025 0.23 AEBP2
 AE binding protein 2
 14148
 0.25
chr7_135604339_135604490 0.23 AC015987.1
6789
 0.16
chr22_46636685_46636903 0.23 CDPF1
 cysteine-rich, DPF motif domain containing 1
 7388
 0.15
chr16_81748374_81748687 0.22 PLCG2
 phospholipase C, gamma 2 (phosphatidylinositol-specific)
 24172
 0.24
chr2_231186113_231186438 0.22 SP140L
 SP140 nuclear body protein-like
 5624
 0.26
chr19_2608004_2608206 0.22 CTC-265F19.2
3755
 0.18
chr19_914979_915242 0.22 R3HDM4
 R3H domain containing 4
 1870
 0.15
chr6_6395826_6395997 0.22 F13A1
 coagulation factor XIII, A1 polypeptide
 74665
 0.11
chr3_39402867_39403018 0.22 SLC25A38
 solute carrier family 25, member 38
 21897
 0.13
chr16_84639875_84640026 0.22 COTL1
 coactosin-like 1 (Dictyostelium)
 11715
 0.16
chr11_64625973_64626226 0.22 CDC42BPG
 CDC42 binding protein kinase gamma (DMPK-like)
 14058
 0.09
chr7_42276890_42277078 0.22 GLI3
 GLI family zinc finger 3
 326
 0.95
chr5_100216168_100216319 0.22 ST8SIA4
 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
 22675
 0.25
chr6_137107555_137107777 0.22 MAP3K5
 mitogen-activated protein kinase kinase kinase 5
 5990
 0.23
chr1_221242594_221242791 0.22 HLX
 H2.0-like homeobox
 188108
 0.03
chr6_15398984_15399345 0.22 JARID2
 jumonji, AT rich interactive domain 2
 1925
 0.43
chr15_78467078_78467229 0.22 IDH3A
 isocitrate dehydrogenase 3 (NAD+) alpha
 11095
 0.15
chr7_42965374_42965592 0.22 PSMA2
 proteasome (prosome, macropain) subunit, alpha type, 2
 6290
 0.2
chr6_139467698_139467849 0.22 HECA
 headcase homolog (Drosophila)
 11524
 0.25
chr10_94674473_94674624 0.22 EXOC6
 exocyst complex component 6
 66271
 0.12
chr11_60790247_60790506 0.22 CD6
 CD6 molecule
 14370
 0.14
chr1_110044414_110044707 0.22 AMIGO1
 adhesion molecule with Ig-like domain 1
 7744
 0.1
chr6_42902274_42902475 0.22 CNPY3
 canopy FGF signaling regulator 3
 5392
 0.11
chr16_57061127_57061278 0.22 NLRC5
 NLR family, CARD domain containing 5
 411
 0.8
chr17_54985578_54985834 0.22 TRIM25
 tripartite motif containing 25
 5682
 0.13
chr7_144474434_144474585 0.22 TPK1
 thiamin pyrophosphokinase 1
 38494
 0.2
chr5_140949949_140950149 0.22 CTD-2024I7.13
12171
 0.11
chrX_19857997_19858148 0.22 SH3KBP1
 SH3-domain kinase binding protein 1
 40203
 0.19
chr19_50431904_50432210 0.22 ATF5
 activating transcription factor 5
 98
 0.81
chr10_73499533_73499684 0.22 C10orf105
 chromosome 10 open reading frame 105
 2027
 0.34
chr22_40781657_40781809 0.22 RP5-1042K10.10
2488
 0.24
chr10_5336359_5336594 0.22 AKR1C7P
 aldo-keto reductase family 1, member C7, pseudogene
 6043
 0.22
chr6_8434992_8435322 0.22 SLC35B3
 solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B3
 559
 0.87
chr2_68966301_68966859 0.22 ARHGAP25
 Rho GTPase activating protein 25
 4566
 0.29
chr8_126658824_126659129 0.22 ENSG00000266452
 .
 202169
 0.03
chr1_161016731_161016999 0.22 USF1
 upstream transcription factor 1
 1098
 0.3
chr4_38673361_38673512 0.22 RP11-617D20.1
6932
 0.18
chr16_4422377_4422562 0.22 VASN
 vasorin
 620
 0.61
chr5_114937358_114937534 0.22 AC010226.4
308
 0.74
chr14_69239916_69240125 0.22 ZFP36L1
 ZFP36 ring finger protein-like 1
 17940
 0.2
chr2_10815541_10815692 0.22 NOL10
 nucleolar protein 10
 3800
 0.22
chr18_68339531_68339691 0.21 GTSCR1
 Gilles de la Tourette syndrome chromosome region, candidate 1
 21631
 0.28
chr5_94378324_94378475 0.21 MCTP1
 multiple C2 domains, transmembrane 1
 25208
 0.24
chrX_40036930_40037081 0.21 BCOR
 BCL6 corepressor
 423
 0.91
chr3_43343509_43343660 0.21 ENSG00000241939
 .
 12859
 0.17
chr1_89587383_89587534 0.21 GBP2
 guanylate binding protein 2, interferon-inducible
 4339
 0.22
chr1_226871894_226872507 0.21 ITPKB-IT1
 ITPKB intronic transcript 1 (non-protein coding)
 9432
 0.21
chr6_47321141_47321456 0.21 TNFRSF21
 tumor necrosis factor receptor superfamily, member 21
 43657
 0.18
chr15_76196509_76196759 0.21 FBXO22
 F-box protein 22
 168
 0.94

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of PBX3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0035405 histone-threonine phosphorylation(GO:0035405)
0.1 0.5 GO:0031061 negative regulation of histone methylation(GO:0031061)
0.1 0.3 GO:0032237 activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.1 0.2 GO:0060340 positive regulation of type I interferon-mediated signaling pathway(GO:0060340)
0.1 0.2 GO:0010572 positive regulation of platelet activation(GO:0010572)
0.1 0.3 GO:0002282 microglial cell activation involved in immune response(GO:0002282)
0.1 0.2 GO:0001672 regulation of chromatin assembly or disassembly(GO:0001672)
0.1 0.2 GO:0034626 fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.1 0.2 GO:0014041 regulation of neuron maturation(GO:0014041) regulation of cell maturation(GO:1903429)
0.1 0.2 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.1 0.2 GO:0046137 negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137)
0.1 0.2 GO:0010459 negative regulation of heart rate(GO:0010459)
0.1 0.2 GO:0021798 forebrain dorsal/ventral pattern formation(GO:0021798)
0.1 0.4 GO:0051001 negative regulation of nitric-oxide synthase activity(GO:0051001)
0.1 0.2 GO:0051665 membrane raft localization(GO:0051665)
0.1 0.2 GO:0021898 commitment of multipotent stem cells to neuronal lineage in forebrain(GO:0021898)
0.1 0.2 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.0 0.1 GO:0032543 mitochondrial translation(GO:0032543)
0.0 0.2 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
0.0 0.4 GO:0007172 signal complex assembly(GO:0007172)
0.0 0.1 GO:0030223 neutrophil differentiation(GO:0030223)
0.0 0.2 GO:0018101 protein citrullination(GO:0018101)
0.0 0.1 GO:0045722 positive regulation of gluconeogenesis(GO:0045722)
0.0 0.1 GO:0002691 regulation of cellular extravasation(GO:0002691) positive regulation of cellular extravasation(GO:0002693)
0.0 0.2 GO:0045349 interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354)
0.0 0.1 GO:0032632 interleukin-3 production(GO:0032632)
0.0 0.1 GO:0006384 transcription initiation from RNA polymerase III promoter(GO:0006384)
0.0 0.0 GO:0033080 immature T cell proliferation in thymus(GO:0033080)
0.0 0.5 GO:0031648 protein destabilization(GO:0031648)
0.0 0.0 GO:0045586 regulation of gamma-delta T cell differentiation(GO:0045586) positive regulation of gamma-delta T cell differentiation(GO:0045588)
0.0 0.0 GO:0002523 leukocyte migration involved in inflammatory response(GO:0002523)
0.0 0.1 GO:0033152 immunoglobulin V(D)J recombination(GO:0033152)
0.0 0.0 GO:0042492 gamma-delta T cell differentiation(GO:0042492)
0.0 0.1 GO:0071392 cellular response to estradiol stimulus(GO:0071392)
0.0 0.1 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0 0.0 GO:0002888 positive regulation of myeloid leukocyte mediated immunity(GO:0002888)
0.0 0.1 GO:0034139 regulation of toll-like receptor 3 signaling pathway(GO:0034139)
0.0 0.1 GO:0006167 AMP biosynthetic process(GO:0006167)
0.0 0.1 GO:0043320 natural killer cell activation involved in immune response(GO:0002323) natural killer cell degranulation(GO:0043320)
0.0 0.2 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.0 0.1 GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling(GO:0010882)
0.0 0.2 GO:0030889 negative regulation of B cell proliferation(GO:0030889)
0.0 0.3 GO:0034260 negative regulation of GTPase activity(GO:0034260)
0.0 0.1 GO:0032525 somite rostral/caudal axis specification(GO:0032525)
0.0 0.1 GO:0046471 phosphatidylglycerol biosynthetic process(GO:0006655) cardiolipin metabolic process(GO:0032048) cardiolipin biosynthetic process(GO:0032049) phosphatidylglycerol metabolic process(GO:0046471)
0.0 0.1 GO:0072385 minus-end-directed organelle transport along microtubule(GO:0072385)
0.0 0.1 GO:0071481 cellular response to X-ray(GO:0071481)
0.0 0.1 GO:0001845 phagolysosome assembly(GO:0001845) phagosome maturation(GO:0090382)
0.0 0.1 GO:0048643 positive regulation of skeletal muscle tissue development(GO:0048643)
0.0 0.2 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 0.1 GO:0010614 negative regulation of cardiac muscle hypertrophy(GO:0010614)
0.0 0.6 GO:0045576 mast cell activation(GO:0045576)
0.0 0.1 GO:0033147 negative regulation of intracellular estrogen receptor signaling pathway(GO:0033147)
0.0 0.1 GO:0071436 sodium ion export(GO:0071436)
0.0 0.1 GO:0032661 interleukin-18 production(GO:0032621) regulation of interleukin-18 production(GO:0032661)
0.0 0.1 GO:2000095 regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000095)
0.0 0.1 GO:0051569 regulation of histone H3-K4 methylation(GO:0051569)
0.0 0.1 GO:0032506 cytokinetic process(GO:0032506)
0.0 0.1 GO:0015917 aminophospholipid transport(GO:0015917)
0.0 0.1 GO:0060586 multicellular organismal iron ion homeostasis(GO:0060586)
0.0 0.1 GO:0002513 tolerance induction to self antigen(GO:0002513)
0.0 0.1 GO:0008354 germ cell migration(GO:0008354)
0.0 0.1 GO:0019441 tryptophan catabolic process to kynurenine(GO:0019441)
0.0 0.1 GO:0032509 endosome transport via multivesicular body sorting pathway(GO:0032509)
0.0 0.1 GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
0.0 0.1 GO:0034616 response to laminar fluid shear stress(GO:0034616)
0.0 0.0 GO:0032613 interleukin-10 production(GO:0032613)
0.0 0.1 GO:0009313 oligosaccharide catabolic process(GO:0009313)
0.0 0.1 GO:0045542 positive regulation of cholesterol biosynthetic process(GO:0045542)
0.0 0.1 GO:0002862 negative regulation of inflammatory response to antigenic stimulus(GO:0002862)
0.0 0.1 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.0 0.2 GO:0050957 equilibrioception(GO:0050957)
0.0 0.0 GO:0090085 regulation of protein deubiquitination(GO:0090085)
0.0 0.1 GO:0050857 positive regulation of antigen receptor-mediated signaling pathway(GO:0050857)
0.0 0.1 GO:0070837 dehydroascorbic acid transport(GO:0070837)
0.0 0.1 GO:0002726 positive regulation of T cell cytokine production(GO:0002726)
0.0 0.3 GO:0032008 positive regulation of TOR signaling(GO:0032008)
0.0 0.1 GO:0001562 response to protozoan(GO:0001562)
0.0 0.1 GO:0051491 positive regulation of filopodium assembly(GO:0051491)
0.0 0.0 GO:0061154 endothelial tube morphogenesis(GO:0061154)
0.0 0.1 GO:0048563 post-embryonic organ morphogenesis(GO:0048563)
0.0 0.1 GO:0019987 obsolete negative regulation of anti-apoptosis(GO:0019987)
0.0 0.3 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.0 0.0 GO:0061030 epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.0 0.0 GO:0006089 lactate metabolic process(GO:0006089)
0.0 0.1 GO:0015801 aromatic amino acid transport(GO:0015801)
0.0 0.0 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.0 0.0 GO:0048537 mucosal-associated lymphoid tissue development(GO:0048537)
0.0 0.1 GO:0032486 Rap protein signal transduction(GO:0032486)
0.0 0.1 GO:0008049 male courtship behavior(GO:0008049)
0.0 0.1 GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress(GO:0008631) cell death in response to oxidative stress(GO:0036473)
0.0 0.1 GO:0043951 negative regulation of cAMP-mediated signaling(GO:0043951)
0.0 0.1 GO:0060219 camera-type eye photoreceptor cell differentiation(GO:0060219)
0.0 0.1 GO:0050686 negative regulation of mRNA processing(GO:0050686) negative regulation of mRNA metabolic process(GO:1903312)
0.0 0.0 GO:0042091 interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.0 0.1 GO:0019859 pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) thymine metabolic process(GO:0019859)
0.0 0.4 GO:0045646 regulation of erythrocyte differentiation(GO:0045646)
0.0 0.0 GO:0001866 NK T cell proliferation(GO:0001866)
0.0 0.2 GO:0007158 neuron cell-cell adhesion(GO:0007158)
0.0 0.0 GO:0021778 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) oligodendrocyte cell fate specification(GO:0021778) glial cell fate specification(GO:0021780)
0.0 0.0 GO:0002335 mature B cell differentiation(GO:0002335)
0.0 0.1 GO:0048712 negative regulation of astrocyte differentiation(GO:0048712)
0.0 0.0 GO:0010310 regulation of hydrogen peroxide metabolic process(GO:0010310)
0.0 0.1 GO:0009221 pyrimidine deoxyribonucleotide biosynthetic process(GO:0009221)
0.0 0.1 GO:2000758 positive regulation of histone acetylation(GO:0035066) positive regulation of protein acetylation(GO:1901985) positive regulation of peptidyl-lysine acetylation(GO:2000758)
0.0 0.0 GO:0072201 negative regulation of mesenchymal cell proliferation(GO:0072201)
0.0 0.3 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.0 0.0 GO:0072600 protein targeting to Golgi(GO:0000042) establishment of protein localization to Golgi(GO:0072600)
0.0 0.1 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.0 0.0 GO:0043374 CD8-positive, alpha-beta T cell activation(GO:0036037) CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0 0.1 GO:0008588 release of cytoplasmic sequestered NF-kappaB(GO:0008588)
0.0 0.1 GO:0060528 secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.0 0.0 GO:0010980 regulation of vitamin D 24-hydroxylase activity(GO:0010979) positive regulation of vitamin D 24-hydroxylase activity(GO:0010980)
0.0 0.1 GO:0022614 membrane to membrane docking(GO:0022614)
0.0 0.1 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.0 0.1 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.0 0.1 GO:0072077 mesenchymal to epithelial transition involved in metanephros morphogenesis(GO:0003337) renal vesicle morphogenesis(GO:0072077) metanephric renal vesicle morphogenesis(GO:0072283)
0.0 0.1 GO:0008298 intracellular mRNA localization(GO:0008298)
0.0 0.0 GO:0010940 positive regulation of necrotic cell death(GO:0010940)
0.0 0.3 GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.0 0.1 GO:0002507 tolerance induction(GO:0002507)
0.0 0.1 GO:0071636 positive regulation of transforming growth factor beta production(GO:0071636)
0.0 0.0 GO:0000301 retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.0 0.1 GO:0006772 thiamine metabolic process(GO:0006772)
0.0 0.1 GO:0061756 leukocyte tethering or rolling(GO:0050901) leukocyte adhesion to vascular endothelial cell(GO:0061756)
0.0 0.1 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.0 0.0 GO:0002724 regulation of T cell cytokine production(GO:0002724)
0.0 0.1 GO:0010508 positive regulation of autophagy(GO:0010508)
0.0 0.3 GO:0045730 respiratory burst(GO:0045730)
0.0 0.0 GO:0015809 arginine transport(GO:0015809)
0.0 0.3 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 0.1 GO:0032836 glomerular basement membrane development(GO:0032836)
0.0 0.1 GO:0032328 alanine transport(GO:0032328)
0.0 0.1 GO:0009972 cytidine catabolic process(GO:0006216) cytidine deamination(GO:0009972) cytidine metabolic process(GO:0046087)
0.0 0.1 GO:0032000 positive regulation of fatty acid beta-oxidation(GO:0032000)
0.0 0.1 GO:0006538 glutamate catabolic process(GO:0006538)
0.0 0.1 GO:0042535 positive regulation of tumor necrosis factor biosynthetic process(GO:0042535)
0.0 0.1 GO:0046033 AMP metabolic process(GO:0046033)
0.0 0.0 GO:0034122 negative regulation of toll-like receptor signaling pathway(GO:0034122)
0.0 0.1 GO:0042989 sequestering of actin monomers(GO:0042989)
0.0 0.0 GO:0006287 base-excision repair, gap-filling(GO:0006287)
0.0 0.1 GO:0031000 response to caffeine(GO:0031000)
0.0 0.0 GO:0071698 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.0 0.0 GO:0001779 natural killer cell differentiation(GO:0001779)
0.0 0.1 GO:0032733 positive regulation of interleukin-10 production(GO:0032733)
0.0 0.1 GO:0045351 type I interferon biosynthetic process(GO:0045351)
0.0 0.1 GO:0002430 complement receptor mediated signaling pathway(GO:0002430)
0.0 0.1 GO:0022417 protein maturation by protein folding(GO:0022417)
0.0 0.1 GO:0043551 regulation of phosphatidylinositol 3-kinase activity(GO:0043551) positive regulation of phosphatidylinositol 3-kinase activity(GO:0043552)
0.0 0.1 GO:0060236 regulation of mitotic spindle organization(GO:0060236)
0.0 0.0 GO:0002903 negative regulation of B cell apoptotic process(GO:0002903)
0.0 0.0 GO:0019228 neuronal action potential(GO:0019228)
0.0 0.0 GO:0006922 obsolete cleavage of lamin involved in execution phase of apoptosis(GO:0006922)
0.0 0.1 GO:0048625 myoblast fate commitment(GO:0048625)
0.0 0.1 GO:0051974 negative regulation of telomerase activity(GO:0051974)
0.0 0.2 GO:0051923 sulfation(GO:0051923)
0.0 0.1 GO:0006032 chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.0 0.1 GO:0090322 regulation of superoxide metabolic process(GO:0090322)
0.0 0.1 GO:0070935 3'-UTR-mediated mRNA stabilization(GO:0070935)
0.0 0.1 GO:0051788 response to misfolded protein(GO:0051788)
0.0 0.1 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0 0.0 GO:0060439 trachea morphogenesis(GO:0060439)
0.0 0.1 GO:0045906 negative regulation of vasoconstriction(GO:0045906)
0.0 0.2 GO:0015693 magnesium ion transport(GO:0015693)
0.0 0.1 GO:0045048 protein insertion into ER membrane(GO:0045048) tail-anchored membrane protein insertion into ER membrane(GO:0071816)
0.0 0.0 GO:0070574 cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
0.0 0.1 GO:0042663 endodermal cell fate specification(GO:0001714) regulation of endodermal cell fate specification(GO:0042663) regulation of endodermal cell differentiation(GO:1903224)
0.0 0.4 GO:1901800 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436) positive regulation of proteasomal protein catabolic process(GO:1901800)
0.0 0.0 GO:0032905 transforming growth factor beta1 production(GO:0032905) regulation of transforming growth factor beta1 production(GO:0032908)
0.0 0.1 GO:0090400 stress-induced premature senescence(GO:0090400)
0.0 0.0 GO:0071360 cellular response to exogenous dsRNA(GO:0071360)
0.0 0.2 GO:0050832 defense response to fungus(GO:0050832)
0.0 0.0 GO:0032790 ribosome disassembly(GO:0032790)
0.0 0.0 GO:0072498 embryonic skeletal joint morphogenesis(GO:0060272) embryonic skeletal joint development(GO:0072498)
0.0 0.2 GO:0006044 N-acetylglucosamine metabolic process(GO:0006044)
0.0 0.1 GO:0032528 microvillus assembly(GO:0030033) microvillus organization(GO:0032528)
0.0 0.1 GO:0048242 epinephrine transport(GO:0048241) epinephrine secretion(GO:0048242)
0.0 0.1 GO:0002052 positive regulation of neuroblast proliferation(GO:0002052)
0.0 0.0 GO:0006154 adenosine catabolic process(GO:0006154)
0.0 0.0 GO:0051097 negative regulation of helicase activity(GO:0051097)
0.0 0.1 GO:0006265 DNA topological change(GO:0006265)
0.0 0.0 GO:0045123 cellular extravasation(GO:0045123)
0.0 0.1 GO:0032814 regulation of natural killer cell activation(GO:0032814)
0.0 0.1 GO:0070498 interleukin-1-mediated signaling pathway(GO:0070498)
0.0 0.1 GO:0016572 histone phosphorylation(GO:0016572)
0.0 0.0 GO:0032898 neurotrophin production(GO:0032898)
0.0 0.1 GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors(GO:0008625) extrinsic apoptotic signaling pathway(GO:0097191)
0.0 0.0 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.0 0.0 GO:0006924 activation-induced cell death of T cells(GO:0006924)
0.0 0.1 GO:0009129 pyrimidine nucleoside monophosphate metabolic process(GO:0009129)
0.0 0.0 GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway(GO:0033148)
0.0 0.0 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.0 0.0 GO:0042362 fat-soluble vitamin biosynthetic process(GO:0042362)
0.0 0.1 GO:0032148 activation of protein kinase B activity(GO:0032148)
0.0 0.0 GO:0002085 inhibition of neuroepithelial cell differentiation(GO:0002085)
0.0 0.1 GO:0060123 regulation of growth hormone secretion(GO:0060123)
0.0 0.0 GO:0030186 melatonin metabolic process(GO:0030186) melatonin biosynthetic process(GO:0030187)
0.0 0.1 GO:0000479 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000447) maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462) cleavage involved in rRNA processing(GO:0000469) endonucleolytic cleavage involved in rRNA processing(GO:0000478) endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000479) RNA phosphodiester bond hydrolysis, endonucleolytic(GO:0090502)
0.0 0.1 GO:0006999 nuclear pore organization(GO:0006999)
0.0 0.1 GO:2000258 negative regulation of complement activation(GO:0045916) negative regulation of protein activation cascade(GO:2000258)
0.0 0.0 GO:0021781 glial cell fate commitment(GO:0021781)
0.0 0.0 GO:0010761 fibroblast migration(GO:0010761)
0.0 0.0 GO:0051103 DNA ligation involved in DNA repair(GO:0051103)
0.0 0.1 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.0 0.0 GO:0043653 mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.0 0.1 GO:0046884 follicle-stimulating hormone secretion(GO:0046884)
0.0 0.3 GO:0007257 activation of JUN kinase activity(GO:0007257)
0.0 0.0 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.0 0.1 GO:0051085 chaperone mediated protein folding requiring cofactor(GO:0051085)
0.0 0.0 GO:0051290 protein heterotetramerization(GO:0051290)
0.0 0.0 GO:0048304 positive regulation of isotype switching to IgG isotypes(GO:0048304)
0.0 0.1 GO:0001782 B cell homeostasis(GO:0001782)
0.0 0.0 GO:0000733 DNA strand renaturation(GO:0000733)
0.0 0.1 GO:0043550 regulation of lipid kinase activity(GO:0043550)
0.0 0.1 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
0.0 0.0 GO:0043931 ossification involved in bone maturation(GO:0043931)
0.0 0.1 GO:0060330 regulation of response to interferon-gamma(GO:0060330) regulation of interferon-gamma-mediated signaling pathway(GO:0060334)
0.0 0.0 GO:0061384 heart trabecula formation(GO:0060347) heart trabecula morphogenesis(GO:0061384)
0.0 0.2 GO:0015893 drug transport(GO:0015893)
0.0 0.1 GO:0006561 proline biosynthetic process(GO:0006561)
0.0 0.1 GO:0007216 G-protein coupled glutamate receptor signaling pathway(GO:0007216)
0.0 0.0 GO:0045603 positive regulation of endothelial cell differentiation(GO:0045603)
0.0 0.0 GO:0019532 oxalate transport(GO:0019532)
0.0 0.0 GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process(GO:0051770)
0.0 0.0 GO:0047484 regulation of response to osmotic stress(GO:0047484)
0.0 0.1 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
0.0 0.1 GO:0000183 chromatin silencing at rDNA(GO:0000183)
0.0 0.1 GO:0019388 galactose catabolic process(GO:0019388)
0.0 0.1 GO:0006422 aspartyl-tRNA aminoacylation(GO:0006422)
0.0 0.0 GO:0045084 positive regulation of interleukin-12 biosynthetic process(GO:0045084)
0.0 0.0 GO:0072205 metanephric collecting duct development(GO:0072205)
0.0 0.5 GO:0006968 cellular defense response(GO:0006968)
0.0 0.0 GO:0019255 glucose 1-phosphate metabolic process(GO:0019255)
0.0 0.2 GO:0050850 positive regulation of calcium-mediated signaling(GO:0050850)
0.0 0.1 GO:0042348 regulation of NF-kappaB import into nucleus(GO:0042345) NF-kappaB import into nucleus(GO:0042348)
0.0 0.1 GO:0015886 heme transport(GO:0015886)
0.0 0.0 GO:0006667 sphinganine metabolic process(GO:0006667)
0.0 0.0 GO:0003402 planar cell polarity pathway involved in axis elongation(GO:0003402)
0.0 0.0 GO:0042726 flavin-containing compound metabolic process(GO:0042726)
0.0 0.0 GO:0043368 positive T cell selection(GO:0043368)
0.0 0.1 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.0 0.1 GO:0050667 homocysteine metabolic process(GO:0050667)
0.0 0.0 GO:0001821 histamine secretion(GO:0001821)
0.0 0.1 GO:0015074 DNA integration(GO:0015074)
0.0 0.0 GO:0042104 positive regulation of activated T cell proliferation(GO:0042104)
0.0 0.0 GO:0045040 outer mitochondrial membrane organization(GO:0007008) protein import into mitochondrial outer membrane(GO:0045040)
0.0 0.2 GO:0006297 nucleotide-excision repair, DNA gap filling(GO:0006297)
0.0 0.2 GO:0034199 activation of protein kinase A activity(GO:0034199)
0.0 0.0 GO:0003351 epithelial cilium movement(GO:0003351) epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
0.0 0.1 GO:0031053 primary miRNA processing(GO:0031053)
0.0 0.0 GO:0019372 lipoxygenase pathway(GO:0019372)
0.0 0.2 GO:1901661 quinone metabolic process(GO:1901661)
0.0 0.1 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)
0.0 0.0 GO:0040016 embryonic cleavage(GO:0040016)
0.0 0.1 GO:0061088 regulation of sequestering of zinc ion(GO:0061088)
0.0 0.0 GO:0001820 serotonin secretion(GO:0001820)
0.0 0.0 GO:0000470 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463) maturation of LSU-rRNA(GO:0000470)
0.0 0.0 GO:0010626 regulation of Schwann cell proliferation(GO:0010624) negative regulation of Schwann cell proliferation(GO:0010626)
0.0 0.1 GO:0006102 isocitrate metabolic process(GO:0006102)
0.0 0.7 GO:0071357 type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357)
0.0 0.0 GO:0060684 epithelial-mesenchymal cell signaling(GO:0060684)
0.0 0.0 GO:0060913 cardiac cell fate determination(GO:0060913)
0.0 0.0 GO:0001831 trophectodermal cellular morphogenesis(GO:0001831)
0.0 0.1 GO:0005513 detection of calcium ion(GO:0005513)
0.0 0.0 GO:0046827 positive regulation of protein export from nucleus(GO:0046827)
0.0 0.1 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.0 0.0 GO:0007638 mechanosensory behavior(GO:0007638)
0.0 0.0 GO:0072531 pyrimidine-containing compound transmembrane transport(GO:0072531)
0.0 0.1 GO:0032205 negative regulation of telomere maintenance(GO:0032205)
0.0 0.0 GO:1901978 positive regulation of spindle checkpoint(GO:0090232) regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267) positive regulation of cell cycle checkpoint(GO:1901978) regulation of mitotic spindle checkpoint(GO:1903504)
0.0 0.0 GO:0060999 positive regulation of dendritic spine development(GO:0060999)
0.0 0.1 GO:0042572 retinol metabolic process(GO:0042572)
0.0 0.1 GO:0045725 positive regulation of glycogen biosynthetic process(GO:0045725)
0.0 0.1 GO:0006388 RNA splicing, via endonucleolytic cleavage and ligation(GO:0000394) tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.0 0.0 GO:0033522 histone H2A ubiquitination(GO:0033522)
0.0 0.0 GO:0071364 cellular response to epidermal growth factor stimulus(GO:0071364)
0.0 0.0 GO:0003283 atrial septum development(GO:0003283) atrial septum morphogenesis(GO:0060413)
0.0 0.1 GO:0032092 positive regulation of protein binding(GO:0032092)
0.0 0.0 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.0 0.0 GO:0014805 smooth muscle adaptation(GO:0014805)
0.0 0.1 GO:0006465 signal peptide processing(GO:0006465)
0.0 0.0 GO:0000089 mitotic metaphase(GO:0000089)
0.0 0.0 GO:0002475 antigen processing and presentation via MHC class Ib(GO:0002475)
0.0 0.0 GO:0090009 primitive streak formation(GO:0090009)
0.0 0.1 GO:0006684 sphingomyelin metabolic process(GO:0006684)
0.0 0.0 GO:0031440 regulation of mRNA 3'-end processing(GO:0031440) positive regulation of mRNA 3'-end processing(GO:0031442) positive regulation of mRNA processing(GO:0050685) positive regulation of mRNA metabolic process(GO:1903313)
0.0 0.1 GO:0009249 protein lipoylation(GO:0009249)
0.0 0.0 GO:0070233 negative regulation of T cell apoptotic process(GO:0070233)
0.0 0.0 GO:0003032 detection of oxygen(GO:0003032)
0.0 0.1 GO:0006516 glycoprotein catabolic process(GO:0006516)
0.0 0.0 GO:0072526 pyridine-containing compound catabolic process(GO:0072526)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0043020 NADPH oxidase complex(GO:0043020)
0.1 0.2 GO:0071986 Ragulator complex(GO:0071986)
0.1 0.3 GO:0031088 platelet dense granule membrane(GO:0031088)
0.0 0.2 GO:0000137 Golgi cis cisterna(GO:0000137)
0.0 0.3 GO:0005652 nuclear lamina(GO:0005652)
0.0 0.2 GO:0043218 compact myelin(GO:0043218)
0.0 0.2 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.0 0.4 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 0.3 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.1 GO:0005826 actomyosin contractile ring(GO:0005826)
0.0 0.1 GO:0032809 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0 0.1 GO:0031313 extrinsic component of vacuolar membrane(GO:0000306) extrinsic component of endosome membrane(GO:0031313)
0.0 0.1 GO:0045323 interleukin-1 receptor complex(GO:0045323)
0.0 0.0 GO:0070044 synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
0.0 0.1 GO:0031205 endoplasmic reticulum Sec complex(GO:0031205)
0.0 0.1 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 0.1 GO:0000942 condensed nuclear chromosome outer kinetochore(GO:0000942)
0.0 0.1 GO:0030119 AP-type membrane coat adaptor complex(GO:0030119)
0.0 0.2 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.1 GO:0032009 early phagosome(GO:0032009)
0.0 0.3 GO:0031519 PcG protein complex(GO:0031519)
0.0 0.2 GO:0048786 presynaptic active zone(GO:0048786)
0.0 0.0 GO:0000778 condensed nuclear chromosome kinetochore(GO:0000778)
0.0 0.0 GO:0001950 obsolete plasma membrane enriched fraction(GO:0001950)
0.0 0.0 GO:0031312 extrinsic component of organelle membrane(GO:0031312)
0.0 0.1 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.0 0.0 GO:0031932 TORC2 complex(GO:0031932)
0.0 0.0 GO:0033270 paranode region of axon(GO:0033270)
0.0 0.1 GO:0042405 nuclear inclusion body(GO:0042405)
0.0 0.0 GO:0060199 clathrin-sculpted glutamate transport vesicle(GO:0060199) clathrin-sculpted glutamate transport vesicle membrane(GO:0060203)
0.0 0.1 GO:0045179 apical cortex(GO:0045179)
0.0 0.2 GO:0043209 myelin sheath(GO:0043209)
0.0 0.2 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.1 GO:0005947 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947)
0.0 0.1 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.0 0.2 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.1 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 0.1 GO:0072379 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.0 0.1 GO:0030895 apolipoprotein B mRNA editing enzyme complex(GO:0030895)
0.0 0.1 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.0 0.1 GO:0070688 MLL5-L complex(GO:0070688)
0.0 0.1 GO:0090576 RNA polymerase III transcription factor complex(GO:0090576)
0.0 0.1 GO:0031083 BLOC complex(GO:0031082) BLOC-1 complex(GO:0031083)
0.0 0.1 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.0 0.0 GO:0031931 TORC1 complex(GO:0031931)
0.0 0.1 GO:0034451 centriolar satellite(GO:0034451)
0.0 0.0 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.1 GO:0008290 F-actin capping protein complex(GO:0008290)
0.0 0.0 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0 0.1 GO:0033553 rDNA heterochromatin(GO:0033553)
0.0 0.2 GO:0016514 SWI/SNF complex(GO:0016514)
0.0 0.0 GO:0000214 tRNA-intron endonuclease complex(GO:0000214)
0.0 0.2 GO:0043195 terminal bouton(GO:0043195)
0.0 0.0 GO:0033150 cytoskeletal calyx(GO:0033150)
0.0 0.2 GO:0042101 T cell receptor complex(GO:0042101)
0.0 0.1 GO:0005827 polar microtubule(GO:0005827)
0.0 0.0 GO:0044462 external encapsulating structure part(GO:0044462)
0.0 0.2 GO:0005844 polysome(GO:0005844)
0.0 0.1 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.0 0.0 GO:0072487 MSL complex(GO:0072487)
0.0 0.0 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 0.1 GO:0061202 clathrin-sculpted gamma-aminobutyric acid transport vesicle(GO:0061200) clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane(GO:0061202)
0.0 0.0 GO:0000124 SAGA complex(GO:0000124)
0.0 0.1 GO:0001772 immunological synapse(GO:0001772)
0.0 0.1 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0 0.1 GO:0035631 CD40 receptor complex(GO:0035631)
0.0 0.0 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.0 0.4 GO:0030118 clathrin coat(GO:0030118)
0.0 0.1 GO:0032156 septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.0 0.0 GO:0005677 chromatin silencing complex(GO:0005677)
0.0 0.3 GO:0005626 obsolete insoluble fraction(GO:0005626)
0.0 0.0 GO:0042827 platelet dense granule(GO:0042827)
0.0 0.0 GO:0070545 PeBoW complex(GO:0070545)
0.0 0.1 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 0.0 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.0 0.1 GO:0016461 unconventional myosin complex(GO:0016461)
0.0 0.0 GO:0001740 Barr body(GO:0001740)
0.0 0.0 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 1.0 GO:0019717 obsolete synaptosome(GO:0019717)
0.0 0.1 GO:0000796 condensin complex(GO:0000796)
0.0 0.1 GO:0005663 DNA replication factor C complex(GO:0005663)
0.0 0.1 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 0.0 GO:0000800 lateral element(GO:0000800)
0.0 0.1 GO:0031010 ISWI-type complex(GO:0031010)
0.0 0.0 GO:0005686 U2 snRNP(GO:0005686)
0.0 0.2 GO:0032420 stereocilium(GO:0032420)
0.0 0.1 GO:0034362 low-density lipoprotein particle(GO:0034362)
0.0 0.0 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 0.1 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 0.2 GO:0005892 acetylcholine-gated channel complex(GO:0005892)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0035184 histone threonine kinase activity(GO:0035184)
0.1 0.5 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.1 0.2 GO:0005152 interleukin-1 receptor antagonist activity(GO:0005152)
0.1 0.2 GO:0047894 flavonol 3-sulfotransferase activity(GO:0047894)
0.1 0.2 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.1 0.2 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.1 0.6 GO:0016493 C-C chemokine receptor activity(GO:0016493)
0.1 0.2 GO:0008420 CTD phosphatase activity(GO:0008420)
0.1 0.2 GO:0033691 sialic acid binding(GO:0033691)
0.1 0.2 GO:0004949 cannabinoid receptor activity(GO:0004949)
0.1 0.2 GO:0047623 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0 0.2 GO:0004668 protein-arginine deiminase activity(GO:0004668)
0.0 0.1 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.0 0.1 GO:0004911 interleukin-2 receptor activity(GO:0004911)
0.0 0.1 GO:0016842 amidine-lyase activity(GO:0016842)
0.0 0.1 GO:0016748 succinyltransferase activity(GO:0016748)
0.0 0.1 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.0 0.1 GO:0061505 DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.0 0.2 GO:0051400 BH domain binding(GO:0051400)
0.0 0.1 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0 0.1 GO:0070492 oligosaccharide binding(GO:0070492)
0.0 0.1 GO:0016312 inositol bisphosphate phosphatase activity(GO:0016312)
0.0 0.3 GO:0030276 clathrin binding(GO:0030276)
0.0 0.1 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 0.4 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.0 0.4 GO:0004697 protein kinase C activity(GO:0004697)
0.0 0.1 GO:0000247 C-8 sterol isomerase activity(GO:0000247)
0.0 0.2 GO:0031434 mitogen-activated protein kinase kinase binding(GO:0031434)
0.0 0.2 GO:0004994 somatostatin receptor activity(GO:0004994)
0.0 0.1 GO:0016417 S-acyltransferase activity(GO:0016417)
0.0 0.2 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.0 0.1 GO:0047499 calcium-independent phospholipase A2 activity(GO:0047499)
0.0 0.1 GO:0003960 NADPH:quinone reductase activity(GO:0003960)
0.0 0.2 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.0 0.2 GO:0009922 fatty acid elongase activity(GO:0009922)
0.0 0.2 GO:0008266 poly(U) RNA binding(GO:0008266)
0.0 0.1 GO:0004999 vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.0 0.1 GO:0030375 thyroid hormone receptor coactivator activity(GO:0030375)
0.0 0.1 GO:0043533 inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.0 0.1 GO:0033300 dehydroascorbic acid transporter activity(GO:0033300)
0.0 0.1 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 0.1 GO:0031404 chloride ion binding(GO:0031404)
0.0 0.1 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0 0.5 GO:0043621 protein self-association(GO:0043621)
0.0 0.0 GO:0042806 fucose binding(GO:0042806)
0.0 0.1 GO:0070087 chromo shadow domain binding(GO:0070087)
0.0 0.1 GO:0016416 carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.0 0.2 GO:0005522 profilin binding(GO:0005522)
0.0 0.1 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor(GO:0050664)
0.0 0.3 GO:0032452 histone demethylase activity(GO:0032452)
0.0 0.1 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0 0.2 GO:0019864 IgG binding(GO:0019864)
0.0 0.1 GO:0031014 troponin T binding(GO:0031014)
0.0 0.1 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.0 0.1 GO:0043422 protein kinase B binding(GO:0043422)
0.0 0.1 GO:0047756 chondroitin 4-sulfotransferase activity(GO:0047756)
0.0 0.1 GO:0004704 NF-kappaB-inducing kinase activity(GO:0004704)
0.0 0.1 GO:0070053 thrombospondin receptor activity(GO:0070053)
0.0 0.1 GO:0003997 acyl-CoA oxidase activity(GO:0003997)
0.0 0.0 GO:0052659 inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658) inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity(GO:0052659)
0.0 0.1 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.0 0.8 GO:0042826 histone deacetylase binding(GO:0042826)
0.0 0.3 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.1 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 0.1 GO:0061630 ubiquitin-ubiquitin ligase activity(GO:0034450) ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659)
0.0 0.1 GO:0008174 mRNA methyltransferase activity(GO:0008174)
0.0 0.1 GO:0035197 siRNA binding(GO:0035197)
0.0 0.1 GO:0046404 ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734)
0.0 0.1 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.0 1.0 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 0.1 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0 0.3 GO:0016892 endoribonuclease activity, producing 3'-phosphomonoesters(GO:0016892)
0.0 0.1 GO:0034190 apolipoprotein receptor binding(GO:0034190)
0.0 0.1 GO:0031013 troponin I binding(GO:0031013)
0.0 0.1 GO:0055106 ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106)
0.0 0.1 GO:0004465 lipoprotein lipase activity(GO:0004465)
0.0 0.1 GO:0050897 cobalt ion binding(GO:0050897)
0.0 0.1 GO:0051766 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440) inositol trisphosphate kinase activity(GO:0051766)
0.0 0.2 GO:0004950 G-protein coupled chemoattractant receptor activity(GO:0001637) chemokine receptor activity(GO:0004950)
0.0 0.2 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 0.3 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.1 GO:0004126 cytidine deaminase activity(GO:0004126)
0.0 0.1 GO:0070402 NADPH binding(GO:0070402)
0.0 0.1 GO:0004476 mannose-6-phosphate isomerase activity(GO:0004476)
0.0 0.1 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.0 0.1 GO:0004514 nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514)
0.0 0.1 GO:0004875 complement receptor activity(GO:0004875)
0.0 0.0 GO:0016019 peptidoglycan receptor activity(GO:0016019)
0.0 0.1 GO:0050733 RS domain binding(GO:0050733)
0.0 0.1 GO:0015194 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.0 0.1 GO:0032405 MutLalpha complex binding(GO:0032405)
0.0 0.2 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity(GO:0034593)
0.0 0.1 GO:0004301 epoxide hydrolase activity(GO:0004301)
0.0 0.0 GO:0019763 immunoglobulin receptor activity(GO:0019763)
0.0 0.1 GO:0003910 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.0 0.1 GO:0003986 acetyl-CoA hydrolase activity(GO:0003986)
0.0 0.3 GO:0008373 sialyltransferase activity(GO:0008373)
0.0 0.3 GO:0019198 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0 0.0 GO:0019958 C-X-C chemokine binding(GO:0019958) interleukin-8 binding(GO:0019959)
0.0 0.1 GO:0004904 interferon receptor activity(GO:0004904)
0.0 0.1 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.0 0.2 GO:0046625 sphingolipid binding(GO:0046625)
0.0 0.0 GO:0010861 thyroid hormone receptor activator activity(GO:0010861)
0.0 0.1 GO:0042834 peptidoglycan binding(GO:0042834)
0.0 0.1 GO:0015232 heme transporter activity(GO:0015232)
0.0 0.2 GO:0005246 calcium channel regulator activity(GO:0005246)
0.0 0.0 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.0 0.1 GO:0005219 ryanodine-sensitive calcium-release channel activity(GO:0005219)
0.0 0.1 GO:0004597 peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.0 0.0 GO:0008184 glycogen phosphorylase activity(GO:0008184)
0.0 0.0 GO:0000400 four-way junction DNA binding(GO:0000400)
0.0 0.0 GO:0071208 histone pre-mRNA DCP binding(GO:0071208)
0.0 0.1 GO:0008517 folic acid transporter activity(GO:0008517)
0.0 0.1 GO:0004568 chitinase activity(GO:0004568)
0.0 0.0 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.0 0.0 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
0.0 0.1 GO:0047023 androsterone dehydrogenase activity(GO:0047023)
0.0 0.0 GO:0098518 polynucleotide phosphatase activity(GO:0098518)
0.0 0.0 GO:0004370 glycerol kinase activity(GO:0004370)
0.0 0.0 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.0 0.3 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 0.0 GO:0002060 purine nucleobase binding(GO:0002060)
0.0 0.1 GO:0004983 neuropeptide Y receptor activity(GO:0004983)
0.0 0.1 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.0 0.0 GO:0000268 peroxisome targeting sequence binding(GO:0000268)
0.0 0.2 GO:0016805 dipeptidase activity(GO:0016805)
0.0 0.0 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.0 0.1 GO:0034739 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) histone deacetylase activity (H4-K16 specific)(GO:0034739) NAD-dependent histone deacetylase activity (H4-K16 specific)(GO:0046970)
0.0 0.2 GO:0016505 peptidase activator activity involved in apoptotic process(GO:0016505)
0.0 0.2 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.0 0.1 GO:0016778 diphosphotransferase activity(GO:0016778)
0.0 0.1 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.0 0.1 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.0 0.0 GO:0004449 isocitrate dehydrogenase (NAD+) activity(GO:0004449)
0.0 0.0 GO:0003726 double-stranded RNA adenosine deaminase activity(GO:0003726)
0.0 0.0 GO:0004466 long-chain-acyl-CoA dehydrogenase activity(GO:0004466)
0.0 0.1 GO:0015925 galactosidase activity(GO:0015925)
0.0 0.0 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0 0.0 GO:0003953 NAD+ nucleosidase activity(GO:0003953)
0.0 0.1 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.0 0.1 GO:0003709 obsolete RNA polymerase III transcription factor activity(GO:0003709)
0.0 0.1 GO:0048406 nerve growth factor binding(GO:0048406)
0.0 0.0 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 0.2 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 0.1 GO:0004815 aspartate-tRNA ligase activity(GO:0004815)
0.0 0.1 GO:0051787 misfolded protein binding(GO:0051787)
0.0 0.1 GO:0031701 angiotensin receptor binding(GO:0031701)
0.0 0.1 GO:0004308 exo-alpha-sialidase activity(GO:0004308) alpha-sialidase activity(GO:0016997)
0.0 0.0 GO:0044020 histone methyltransferase activity (H4-R3 specific)(GO:0044020)
0.0 0.0 GO:0030343 vitamin D3 25-hydroxylase activity(GO:0030343) vitamin D 25-hydroxylase activity(GO:0070643)
0.0 0.1 GO:0017127 cholesterol transporter activity(GO:0017127)
0.0 0.0 GO:0042608 T cell receptor binding(GO:0042608)
0.0 0.1 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.0 0.1 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0 0.4 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.0 0.0 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process(GO:0043028)
0.0 0.1 GO:0016944 obsolete RNA polymerase II transcription elongation factor activity(GO:0016944)
0.0 0.0 GO:0043141 ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.0 0.1 GO:0016165 linoleate 13S-lipoxygenase activity(GO:0016165)
0.0 0.0 GO:0031685 adenosine receptor binding(GO:0031685)
0.0 0.0 GO:0031177 phosphopantetheine binding(GO:0031177)
0.0 0.3 GO:0001608 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.0 GO:0035586 purinergic receptor activity(GO:0035586)
0.0 0.0 GO:0043008 ATP-dependent protein binding(GO:0043008)
0.0 0.3 GO:0002039 p53 binding(GO:0002039)
0.0 0.3 GO:0016831 carboxy-lyase activity(GO:0016831)
0.0 0.1 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.0 0.0 GO:0004477 methenyltetrahydrofolate cyclohydrolase activity(GO:0004477)
0.0 0.0 GO:0035198 miRNA binding(GO:0035198)
0.0 0.1 GO:0015385 sodium:proton antiporter activity(GO:0015385)
0.0 0.0 GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640) G-protein coupled glutamate receptor activity(GO:0098988)
0.0 0.0 GO:0005113 patched binding(GO:0005113)
0.0 0.1 GO:0033170 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0 0.0 GO:0015278 calcium-release channel activity(GO:0015278) ligand-gated calcium channel activity(GO:0099604)
0.0 0.2 GO:0070566 adenylyltransferase activity(GO:0070566)
0.0 0.0 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0 0.1 GO:0032393 MHC class I receptor activity(GO:0032393)
0.0 0.1 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 0.3 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 0.1 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.0 0.1 GO:0016723 oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor(GO:0016723)
0.0 0.2 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.0 0.1 GO:0004908 interleukin-1 receptor activity(GO:0004908)
0.0 0.2 GO:0030552 cAMP binding(GO:0030552)
0.0 0.1 GO:0017040 ceramidase activity(GO:0017040)
0.0 0.0 GO:0015379 potassium:chloride symporter activity(GO:0015379)
0.0 0.2 GO:0004889 acetylcholine-activated cation-selective channel activity(GO:0004889)
0.0 0.0 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.0 0.1 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.0 GO:0015562 efflux transmembrane transporter activity(GO:0015562)
0.0 0.0 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.0 0.0 GO:0004607 phosphatidylcholine-sterol O-acyltransferase activity(GO:0004607)
0.0 0.1 GO:0051635 obsolete bacterial cell surface binding(GO:0051635)
0.0 0.1 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.2 PID CD8 TCR PATHWAY TCR signaling in naïve CD8+ T cells
0.0 0.2 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions
0.0 0.4 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 0.8 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.0 0.2 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
0.0 0.3 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.0 0.2 PID IL5 PATHWAY IL5-mediated signaling events
0.0 1.2 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.0 0.3 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 0.4 PID EPO PATHWAY EPO signaling pathway
0.0 0.3 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.0 0.2 PID GMCSF PATHWAY GMCSF-mediated signaling events
0.0 0.2 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 0.2 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.0 0.4 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.0 0.0 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 0.0 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.0 0.4 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events
0.0 0.5 PID NFAT 3PATHWAY Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.0 0.2 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.0 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 0.5 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.0 0.5 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 0.3 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 0.1 PID CD40 PATHWAY CD40/CD40L signaling
0.0 0.5 PID RAC1 PATHWAY RAC1 signaling pathway
0.0 0.2 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 0.2 PID ARF6 PATHWAY Arf6 signaling events
0.0 0.0 ST GRANULE CELL SURVIVAL PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.0 0.6 PID MET PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.0 0.3 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.0 0.0 PID REELIN PATHWAY Reelin signaling pathway
0.0 0.1 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.0 0.1 PID ERBB4 PATHWAY ErbB4 signaling events
0.0 0.0 SIG PIP3 SIGNALING IN CARDIAC MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.0 0.3 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 0.2 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 0.1 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.2 PID IL6 7 PATHWAY IL6-mediated signaling events
0.0 0.2 SIG PIP3 SIGNALING IN B LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.0 0.0 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 0.3 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 0.0 PID S1P S1P2 PATHWAY S1P2 pathway
0.0 0.2 PID IL1 PATHWAY IL1-mediated signaling events
0.0 0.3 PID ATM PATHWAY ATM pathway
0.0 0.0 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 0.1 PID PI3KCI PATHWAY Class I PI3K signaling events
0.0 0.0 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.0 0.1 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.
0.0 0.1 SIG CD40PATHWAYMAP Genes related to CD40 signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0 0.5 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 1.2 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0 0.1 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
0.0 0.4 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.0 0.3 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.0 0.7 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.0 0.4 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0 0.4 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.0 0.1 REACTOME INFLAMMASOMES Genes involved in Inflammasomes
0.0 0.2 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.0 0.3 REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.0 0.0 REACTOME PLATELET SENSITIZATION BY LDL Genes involved in Platelet sensitization by LDL
0.0 0.3 REACTOME ENOS ACTIVATION AND REGULATION Genes involved in eNOS activation and regulation
0.0 0.7 REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.0 0.5 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 0.2 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 0.3 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 0.9 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 0.3 REACTOME GPVI MEDIATED ACTIVATION CASCADE Genes involved in GPVI-mediated activation cascade
0.0 0.3 REACTOME G1 PHASE Genes involved in G1 Phase
0.0 0.8 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.0 0.1 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.0 0.2 REACTOME INITIAL TRIGGERING OF COMPLEMENT Genes involved in Initial triggering of complement
0.0 0.4 REACTOME RORA ACTIVATES CIRCADIAN EXPRESSION Genes involved in RORA Activates Circadian Expression
0.0 0.2 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.1 REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0 0.4 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 0.3 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 0.2 REACTOME REPAIR SYNTHESIS FOR GAP FILLING BY DNA POL IN TC NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.0 0.2 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.0 0.1 REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.0 0.2 REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB Genes involved in PKA-mediated phosphorylation of CREB
0.0 0.5 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.1 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.0 0.7 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.1 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.0 0.1 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions
0.0 0.2 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 0.2 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.0 REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10 Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
0.0 0.2 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.0 0.1 REACTOME TRAF6 MEDIATED NFKB ACTIVATION Genes involved in TRAF6 mediated NF-kB activation
0.0 0.0 REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI Genes involved in RIP-mediated NFkB activation via DAI
0.0 0.2 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 0.2 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.0 0.1 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 0.0 REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION Genes involved in activated TAK1 mediates p38 MAPK activation
0.0 0.2 REACTOME RECYCLING PATHWAY OF L1 Genes involved in Recycling pathway of L1
0.0 0.1 REACTOME HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
0.0 0.1 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.0 0.0 REACTOME PEPTIDE HORMONE BIOSYNTHESIS Genes involved in Peptide hormone biosynthesis
0.0 0.2 REACTOME KERATAN SULFATE BIOSYNTHESIS Genes involved in Keratan sulfate biosynthesis
0.0 0.0 REACTOME INTEGRATION OF PROVIRUS Genes involved in Integration of provirus
0.0 0.1 REACTOME P38MAPK EVENTS Genes involved in p38MAPK events
0.0 0.1 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex
0.0 0.1 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.0 REACTOME G PROTEIN ACTIVATION Genes involved in G-protein activation
0.0 0.0 REACTOME SIGNALING BY ERBB2 Genes involved in Signaling by ERBB2