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ENCODE: H3K4me1 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for PDX1

Z-value: 0.84

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Transcription factors associated with PDX1

Gene Symbol	Gene ID	Gene Info
PDX1 Ensembl NCBI GeneCards UniProt	ENSG00000139515.5	PDX1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
PDX1	chr13_28491302_28491453	2780	0.210847	-0.77	1.6e-02	Click!
PDX1	chr13_28492869_28493020	1213	0.386310	-0.58	9.8e-02	Click!
PDX1	chr13_28491766_28492143	2203	0.242018	-0.44	2.3e-01	Click!
PDX1	chr13_28493501_28493652	581	0.661953	-0.43	2.5e-01	Click!
PDX1	chr13_28492279_28492430	1803	0.279266	-0.42	2.5e-01	Click!

Activity of the PDX1 motif across conditions

Conditions sorted by the z-value of the PDX1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr7_46949633_46949784	0.73	AC011294.3	Uncharacterized protein	212988	0.03
chr16_17931428_17931579	0.73	XYLT1	xylosyltransferase I	366765	0.01
chr5_39411390_39411705	0.59	DAB2	Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)	13423	0.26
chr7_17412244_17412395	0.59	ENSG00000199473	.	631	0.81
chr18_72443447_72443598	0.58	ZNF407	zinc finger protein 407	100546	0.08
chr8_118960048_118960199	0.52	EXT1	exostosin glycosyltransferase 1	162530	0.04
chr3_156478754_156479058	0.51	LEKR1	leucine, glutamate and lysine rich 1	65183	0.12
chr2_65008994_65009145	0.50	ENSG00000253082	.	5831	0.22
chr5_77886942_77887093	0.45	LHFPL2	lipoma HMGIC fusion partner-like 2	42043	0.21
chr1_31870163_31870721	0.45	SERINC2	serine incorporator 2	11970	0.15
chr9_4137653_4137928	0.45	GLIS3	GLIS family zinc finger 3	7403	0.28
chr13_24782132_24782457	0.43	SPATA13	spermatogenesis associated 13	43538	0.13
chr2_19237763_19237914	0.43	ENSG00000266738	.	310352	0.01
chr3_45521797_45522168	0.42	LARS2-AS1	LARS2 antisense RNA 1	29055	0.2
chr9_124161266_124161489	0.42	RP11-162D16.2		23858	0.15
chr7_24741561_24741712	0.40	DFNA5	deafness, autosomal dominant 5	4209	0.34
chr12_95597054_95597379	0.40	FGD6	FYVE, RhoGEF and PH domain containing 6	13939	0.18
chr10_78923339_78923671	0.40	RP11-180I22.2		15455	0.25
chr15_90392195_90392442	0.39	ENSG00000264966	.	1635	0.26
chr1_109740426_109740857	0.39	ENSG00000238310	.	9829	0.15
chr5_14264414_14265476	0.38	TRIO	trio Rho guanine nucleotide exchange factor	26141	0.27
chr6_10085176_10085327	0.38	OFCC1	orofacial cleft 1 candidate 1	29756	0.25
chr5_17282736_17283060	0.37	ENSG00000252908	.	42178	0.15
chr7_101457741_101458764	0.37	CUX1	cut-like homeobox 1	707	0.73
chr10_23114375_23114526	0.37	ENSG00000206842	.	38128	0.19
chr16_67439717_67439868	0.37	ZDHHC1	zinc finger, DHHC-type containing 1	4898	0.11
chr5_39072103_39073220	0.36	RICTOR	RPTOR independent companion of MTOR, complex 2	1830	0.43
chr11_34997556_34998012	0.36	PDHX	pyruvate dehydrogenase complex, component X	1547	0.44
chr10_63603062_63603213	0.36	ARID5B	AT rich interactive domain 5B (MRF1-like)	57922	0.14
chr4_24553435_24554115	0.36	ENSG00000243005	.	11309	0.21
chr8_59742095_59742246	0.36	ENSG00000201231	.	15059	0.28
chr13_76867098_76867386	0.36	ENSG00000243274	.	158175	0.04
chr14_54574129_54574280	0.35	BMP4	bone morphogenetic protein 4	148725	0.04
chr6_56534653_56534887	0.35	DST	dystonin	26976	0.25
chr10_6763840_6763991	0.35	PRKCQ	protein kinase C, theta	141652	0.05
chr3_81793119_81793296	0.35	GBE1	glucan (1,4-alpha-), branching enzyme 1	427	0.92
chr6_132082478_132082629	0.35	ENSG00000266807	.	30759	0.14
chr11_126456164_126456315	0.35	KIRREL3-AS1	KIRREL3 antisense RNA 1	42397	0.16
chr3_81777594_81777815	0.34	GBE1	glucan (1,4-alpha-), branching enzyme 1	15076	0.31
chr3_11254129_11254425	0.34	HRH1	histamine receptor H1	13440	0.26
chr2_224966339_224966634	0.34	SERPINE2	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2	62450	0.13
chr10_102761652_102761861	0.34	LZTS2	leucine zipper, putative tumor suppressor 2	2146	0.16
chr1_221872835_221873035	0.34	DUSP10	dual specificity phosphatase 10	37867	0.23
chr1_196578004_196578155	0.34	KCNT2	potassium channel, subfamily T, member 2	276	0.93
chr6_113660616_113660767	0.33	ENSG00000222677	.	175498	0.03
chr10_52085009_52085183	0.33	AC069547.1	HCG1745369; PRO3073; Uncharacterized protein	9202	0.2
chr5_149679633_149679784	0.33	ARSI	arylsulfatase family, member I	2808	0.25
chr3_58369457_58369608	0.33	PXK	PX domain containing serine/threonine kinase	11869	0.19
chr1_59289424_59289575	0.33	JUN	jun proto-oncogene	39714	0.18
chr1_100110656_100110807	0.33	PALMD	palmdelphin	768	0.75
chr6_81163819_81163970	0.33	BCKDHB	branched chain keto acid dehydrogenase E1, beta polypeptide	347511	0.01
chr13_102102047_102102198	0.32	ITGBL1	integrin, beta-like 1 (with EGF-like repeat domains)	2844	0.36
chr18_71856871_71857022	0.32	TIMM21	translocase of inner mitochondrial membrane 21 homolog (yeast)	34536	0.16
chr12_124476513_124476664	0.32	ZNF664	zinc finger protein 664	18746	0.08
chr2_224683617_224683768	0.32	AP1S3	adaptor-related protein complex 1, sigma 3 subunit	18509	0.26
chr17_64419641_64419918	0.32	RP11-4F22.2		6807	0.26
chr9_118837376_118837527	0.32	PAPPA	pregnancy-associated plasma protein A, pappalysin 1	78632	0.11
chr18_45560087_45560238	0.32	ZBTB7C	zinc finger and BTB domain containing 7C	7332	0.29
chr8_54780688_54780839	0.32	RP11-1070A24.2		8446	0.18
chr17_53804440_53804591	0.32	TMEM100	transmembrane protein 100	4298	0.29
chr8_129798902_129799053	0.32	ENSG00000221351	.	33063	0.25
chr7_29028937_29029088	0.32	AC005162.5		2368	0.31
chr5_150024876_150025027	0.32	SYNPO	synaptopodin	4711	0.16
chr1_180549413_180549564	0.31	ENSG00000266683	.	34520	0.16
chr17_64297527_64298255	0.31	PRKCA	protein kinase C, alpha	1053	0.55
chr12_110493934_110494306	0.31	C12orf76	chromosome 12 open reading frame 76	7030	0.2
chr11_108487825_108487976	0.31	EXPH5	exophilin 5	23435	0.21
chr2_205530356_205530507	0.31	PARD3B	par-3 family cell polarity regulator beta	119708	0.07
chr17_60074998_60075962	0.31	ENSG00000242398	.	7868	0.17
chr7_151297372_151297523	0.31	PRKAG2	protein kinase, AMP-activated, gamma 2 non-catalytic subunit	31992	0.18
chr20_13781196_13781347	0.31	NDUFAF5	NADH dehydrogenase (ubiquinone) complex I, assembly factor 5	15575	0.22
chr4_87260645_87260796	0.31	ENSG00000252757	.	2953	0.32
chr13_33836579_33836730	0.31	ENSG00000236581	.	8862	0.23
chr4_54425031_54425364	0.31	LNX1	ligand of numb-protein X 1, E3 ubiquitin protein ligase	813	0.67
chr10_30388154_30388305	0.31	KIAA1462	KIAA1462	39776	0.21
chr4_75072940_75073180	0.31	AC093677.1	Uncharacterized protein	48975	0.12
chr5_95415281_95415432	0.31	ENSG00000207578	.	514	0.85
chr7_33020923_33021074	0.31	FKBP9	FK506 binding protein 9, 63 kDa	1887	0.3
chr20_10844545_10844731	0.30	RP11-103J8.1		38294	0.22
chr10_99995580_99995731	0.30	RP11-34A14.3		16125	0.21
chr18_12742991_12743142	0.30	ENSG00000201466	.	17650	0.15
chr4_95454799_95455193	0.30	PDLIM5	PDZ and LIM domain 5	10120	0.32
chr17_48124722_48124974	0.30	ITGA3	integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)	8491	0.14
chrX_16861423_16861574	0.30	RBBP7	retinoblastoma binding protein 7	8690	0.18
chr11_66799605_66799756	0.30	SYT12	synaptotagmin XII	4649	0.16
chr3_156025423_156025574	0.30	KCNAB1	potassium voltage-gated channel, shaker-related subfamily, beta member 1	15801	0.26
chr4_182873147_182873298	0.30	ENSG00000251742	.	116961	0.06
chr11_107433298_107433449	0.30	ALKBH8	alkB, alkylation repair homolog 8 (E. coli)	2871	0.27
chr9_115317323_115317474	0.30	C9orf147	chromosome 9 open reading frame 147	67914	0.11
chr11_1580523_1580674	0.30	DUSP8	dual specificity phosphatase 8	6568	0.13
chr18_415803_416022	0.30	RP11-720L2.2		8504	0.25
chr3_188668964_188669115	0.30	TPRG1	tumor protein p63 regulated 1	4036	0.37
chr5_77190041_77190192	0.30	TBCA	tubulin folding cofactor A	25512	0.25
chr15_59560424_59560575	0.30	RP11-429D19.1		2862	0.21
chr2_216326541_216326692	0.30	AC012462.1		25640	0.2
chr4_74571517_74571668	0.30	IL8	interleukin 8	34631	0.18
chr22_26717807_26718076	0.30	SEZ6L	seizure related 6 homolog (mouse)-like	25740	0.18
chr10_112083656_112083807	0.29	SMNDC1	survival motor neuron domain containing 1	19022	0.23
chr9_125146729_125146880	0.29	AL162424.1	Uncharacterized protein	2124	0.22
chr12_52837042_52837193	0.29	KRT6B	keratin 6B	8793	0.1
chr10_100076549_100076804	0.29	LOXL4	lysyl oxidase-like 4	48669	0.13
chr1_85163731_85163882	0.29	SSX2IP	synovial sarcoma, X breakpoint 2 interacting protein	7320	0.25
chr2_192168870_192169021	0.29	MYO1B	myosin IB	27334	0.22
chr3_172038302_172038563	0.29	AC092964.1	Uncharacterized protein	4214	0.26
chr2_228735932_228736236	0.29	DAW1	dynein assembly factor with WDR repeat domains 1	239	0.94
chr20_11120768_11120919	0.29	C20orf187	chromosome 20 open reading frame 187	112032	0.07
chr9_109952511_109952662	0.29	RP11-508N12.2		87317	0.09
chr14_35169641_35169792	0.29	CFL2	cofilin 2 (muscle)	13318	0.18
chr1_95440168_95440319	0.29	RP4-639F20.1		13362	0.2
chr4_16252476_16252627	0.29	TAPT1-AS1	TAPT1 antisense RNA 1 (head to head)	23883	0.19
chr3_189655319_189655470	0.29	ENSG00000216058	.	107683	0.07
chr8_126291633_126291784	0.29	ENSG00000242170	.	8862	0.26
chr3_177463007_177463158	0.29	ENSG00000200288	.	120885	0.06
chr1_240507937_240508088	0.29	ENSG00000252317	.	3327	0.31
chr7_16168760_16168911	0.29	ISPD-AS1	ISPD antisense RNA 1	81278	0.11
chr12_16504068_16504219	0.29	MGST1	microsomal glutathione S-transferase 1	463	0.87
chr13_107160759_107160952	0.29	EFNB2	ephrin-B2	26607	0.24
chr17_16281825_16281976	0.29	UBB	ubiquitin B	2212	0.22
chr11_108564488_108564639	0.28	DDX10	DEAD (Asp-Glu-Ala-Asp) box polypeptide 10	28714	0.23
chr2_159866696_159866847	0.28	ENSG00000202029	.	16883	0.21
chr4_129309196_129309347	0.28	PGRMC2	progesterone receptor membrane component 2	99287	0.09
chr2_97452558_97452709	0.28	CNNM4	cyclin M4	1689	0.29
chr13_46066295_46066446	0.28	COG3	component of oligomeric golgi complex 3	27310	0.17
chr1_236046467_236046618	0.28	LYST	lysosomal trafficking regulator	330	0.87
chr1_215039039_215039190	0.28	KCNK2	potassium channel, subfamily K, member 2	140084	0.05
chr3_27367738_27367889	0.28	NEK10	NIMA-related kinase 10	34765	0.16
chr11_8928681_8928832	0.28	ST5	suppression of tumorigenicity 5	3742	0.13
chr6_11767541_11767692	0.28	ADTRP	androgen-dependent TFPI-regulating protein	11420	0.27
chr22_27816562_27816713	0.28	RP11-375H17.1		295831	0.01
chr1_85064390_85064541	0.28	CTBS	chitobiase, di-N-acetyl-	24318	0.17
chr9_38039342_38039926	0.28	SHB	Src homology 2 domain containing adaptor protein B	29574	0.21
chr11_58941542_58941693	0.28	DTX4	deltex homolog 4 (Drosophila)	1652	0.33
chr12_15879564_15879715	0.28	EPS8	epidermal growth factor receptor pathway substrate 8	1560	0.5
chr16_84210184_84210335	0.28	DNAAF1	dynein, axonemal, assembly factor 1	512	0.67
chr5_110725476_110725627	0.28	CTC-499J9.1		87286	0.08
chr19_43356290_43356490	0.27	PSG10P	pregnancy specific beta-1-glycoprotein 10, pseudogene	3381	0.21
chr14_91090982_91091133	0.27	TTC7B	tetratricopeptide repeat domain 7B	6690	0.2
chr5_73463660_73463811	0.27	ENSG00000222551	.	103855	0.08
chr9_127072608_127072759	0.27	NEK6	NIMA-related kinase 6	10419	0.19
chr11_106239373_106239524	0.27	RP11-680E19.1		104406	0.08
chr11_33712841_33713004	0.27	RP4-541C22.5		5325	0.18
chr1_230222948_230223099	0.27	GALNT2	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 (GalNAc-T2)	20005	0.23
chr17_79855827_79855978	0.27	NPB	neuropeptide B	2719	0.08
chr1_185066313_185066464	0.27	TRMT1L	tRNA methyltransferase 1 homolog (S. cerevisiae)-like	42304	0.13
chr6_48743198_48743349	0.27	ENSG00000221175	.	74287	0.13
chr14_76289523_76289812	0.27	RP11-270M14.4		13887	0.25
chr19_43392666_43392817	0.27	PSG1	pregnancy specific beta-1-glycoprotein 1	8870	0.17
chr10_128556488_128556639	0.27	DOCK1	dedicator of cytokinesis 1	37415	0.18
chr7_127410389_127410540	0.27	SND1	staphylococcal nuclease and tudor domain containing 1	117501	0.05
chr1_3230129_3230570	0.27	PRDM16	PR domain containing 16	69653	0.11
chr10_17261059_17261210	0.27	VIM-AS1	VIM antisense RNA 1	7763	0.16
chr11_75269832_75269983	0.27	SERPINH1	serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)	3194	0.18
chr13_106835108_106835518	0.27	ENSG00000222682	.	27474	0.23
chr1_183851401_183851702	0.27	COLGALT2	collagen beta(1-O)galactosyltransferase 2	64201	0.12
chr19_43652929_43653080	0.27	PSG5	pregnancy specific beta-1-glycoprotein 5	37638	0.14
chr1_156232399_156232550	0.27	PAQR6	progestin and adipoQ receptor family member VI	14593	0.09
chr15_34415216_34415367	0.27	PGBD4	piggyBac transposable element derived 4	21017	0.15
chr5_36374010_36374366	0.27	RANBP3L	RAN binding protein 3-like	71972	0.11
chr4_151494582_151494735	0.27	RP11-1336O20.2		5583	0.24
chr5_123737339_123737490	0.27	RP11-436H11.2		327110	0.01
chr20_10502069_10502225	0.27	SLX4IP	SLX4 interacting protein	86196	0.09
chr20_59830581_59830732	0.27	CDH4	cadherin 4, type 1, R-cadherin (retinal)	3174	0.41
chr16_48444372_48444523	0.27	ENSG00000265077	.	4242	0.18
chr8_41053658_41053809	0.26	ENSG00000263372	.	74929	0.09
chr4_90040818_90040969	0.26	TIGD2	tigger transposable element derived 2	6925	0.23
chr10_89436229_89436444	0.26	PAPSS2	3'-phosphoadenosine 5'-phosphosulfate synthase 2	15628	0.19
chr14_103480838_103481545	0.26	CDC42BPB	CDC42 binding protein kinase beta (DMPK-like)	42608	0.12
chr14_42609922_42610073	0.26	ENSG00000222084	.	159957	0.04
chr1_219259694_219259888	0.26	LYPLAL1	lysophospholipase-like 1	87395	0.1
chr17_53812177_53812328	0.26	TMEM100	transmembrane protein 100	2770	0.34
chr1_15355114_15355265	0.26	KAZN	kazrin, periplakin interacting protein	82774	0.1
chr3_111522709_111522860	0.26	PHLDB2	pleckstrin homology-like domain, family B, member 2	55243	0.14
chr5_17223674_17224319	0.26	BASP1	brain abundant, membrane attached signal protein 1	6327	0.19
chr16_86806268_86806419	0.26	FOXL1	forkhead box L1	194228	0.03
chr13_100776751_100776902	0.26	PCCA	propionyl CoA carboxylase, alpha polypeptide	35489	0.21
chr13_31367185_31367336	0.26	ALOX5AP	arachidonate 5-lipoxygenase-activating protein	57615	0.14
chr6_79325243_79325394	0.26	IRAK1BP1	interleukin-1 receptor-associated kinase 1 binding protein 1	251871	0.02
chr8_36738584_36738735	0.26	KCNU1	potassium channel, subfamily U, member 1	47764	0.19
chr11_29315204_29315355	0.26	ENSG00000211499	.	17043	0.31
chr6_25230157_25230308	0.26	ENSG00000264238	.	26751	0.14
chr9_17004159_17004310	0.26	ENSG00000241152	.	49665	0.18
chr10_125793430_125793581	0.26	CHST15	carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15	12736	0.27
chr7_90013217_90013368	0.26	CLDN12	claudin 12	257	0.93
chr17_41496073_41496238	0.26	ENSG00000251763	.	6360	0.12
chr7_32201162_32201313	0.26	PDE1C	phosphodiesterase 1C, calmodulin-dependent 70kDa	90189	0.1
chr5_167156903_167157054	0.25	CTB-78F1.2		8610	0.23
chr7_55132299_55132450	0.25	EGFR	epidermal growth factor receptor	45042	0.19
chr1_178244906_178245188	0.25	RASAL2	RAS protein activator like 2	65559	0.14
chr1_196150065_196150216	0.25	ENSG00000265986	.	401471	0.01
chr11_102722401_102722552	0.25	MMP3	matrix metallopeptidase 3 (stromelysin 1, progelatinase)	7942	0.19
chr4_128619906_128620188	0.25	INTU	inturned planar cell polarity protein	11078	0.23
chr2_56148778_56148929	0.25	EFEMP1	EGF containing fibulin-like extracellular matrix protein 1	1503	0.42
chr10_20218216_20218367	0.25	PLXDC2	plexin domain containing 2	113123	0.06
chr6_1798322_1798473	0.25	FOXC1	forkhead box C1	187716	0.03
chr1_86020329_86020665	0.25	DDAH1	dimethylarginine dimethylaminohydrolase 1	23436	0.17
chr3_139905404_139905555	0.25	ENSG00000263959	.	216783	0.02
chr17_17912103_17912254	0.25	LRRC48	leucine rich repeat containing 48	1840	0.25
chr12_6292503_6292996	0.25	CD9	CD9 molecule	16132	0.18
chr12_102461670_102461821	0.25	RP11-554E23.4		4612	0.2
chr8_41906632_41907752	0.25	KAT6A	K(lysine) acetyltransferase 6A	2313	0.3

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of PDX1

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View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.5	GO:0048149	behavioral response to ethanol(GO:0048149)
0.1	0.3	GO:0032509	endosome transport via multivesicular body sorting pathway(GO:0032509)
0.1	0.1	GO:0060028	convergent extension involved in axis elongation(GO:0060028)
0.1	0.2	GO:0021827	cerebral cortex tangential migration using cell-cell interactions(GO:0021823) substrate-dependent cerebral cortex tangential migration(GO:0021825) postnatal olfactory bulb interneuron migration(GO:0021827)
0.1	0.3	GO:0051497	negative regulation of stress fiber assembly(GO:0051497)
0.1	0.2	GO:0007386	compartment pattern specification(GO:0007386)
0.1	0.1	GO:0002541	activation of plasma proteins involved in acute inflammatory response(GO:0002541)
0.1	0.1	GO:0019372	lipoxygenase pathway(GO:0019372)
0.1	0.2	GO:0043589	skin morphogenesis(GO:0043589)
0.1	0.2	GO:0070254	mucus secretion(GO:0070254)
0.1	0.3	GO:0000301	retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.0	0.2	GO:2000095	regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000095)
0.0	0.1	GO:0071436	sodium ion export(GO:0071436)
0.0	0.1	GO:0007221	positive regulation of transcription of Notch receptor target(GO:0007221)
0.0	0.1	GO:0044415	evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.0	0.1	GO:0060083	smooth muscle contraction involved in micturition(GO:0060083)
0.0	0.1	GO:0060831	smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:0060831)
0.0	0.4	GO:0033137	negative regulation of peptidyl-serine phosphorylation(GO:0033137)
0.0	0.3	GO:0007185	transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0	0.4	GO:0009629	response to gravity(GO:0009629)
0.0	0.1	GO:0010766	negative regulation of sodium ion transport(GO:0010766)
0.0	0.2	GO:0070141	response to UV-A(GO:0070141)
0.0	0.1	GO:0047484	regulation of response to osmotic stress(GO:0047484)
0.0	0.1	GO:0061430	bone trabecula formation(GO:0060346) bone trabecula morphogenesis(GO:0061430)
0.0	0.1	GO:2000143	negative regulation of transcription initiation from RNA polymerase II promoter(GO:0060633) negative regulation of DNA-templated transcription, initiation(GO:2000143)
0.0	0.1	GO:0001778	plasma membrane repair(GO:0001778)
0.0	0.1	GO:0010936	negative regulation of macrophage cytokine production(GO:0010936)
0.0	0.1	GO:0010757	negative regulation of plasminogen activation(GO:0010757)
0.0	0.1	GO:0032898	neurotrophin production(GO:0032898)
0.0	0.2	GO:0007171	activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.0	0.1	GO:0010193	response to ozone(GO:0010193)
0.0	0.1	GO:0031665	negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.0	0.3	GO:0060390	regulation of SMAD protein import into nucleus(GO:0060390)
0.0	0.1	GO:0030505	inorganic diphosphate transport(GO:0030505)
0.0	0.1	GO:0010837	regulation of keratinocyte proliferation(GO:0010837)
0.0	0.1	GO:0051305	chromosome movement towards spindle pole(GO:0051305)
0.0	0.1	GO:0022605	oogenesis stage(GO:0022605)
0.0	0.1	GO:0002043	blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.0	0.1	GO:0030538	embryonic genitalia morphogenesis(GO:0030538)
0.0	0.4	GO:0050930	induction of positive chemotaxis(GO:0050930)
0.0	0.2	GO:0060638	mesenchymal-epithelial cell signaling(GO:0060638)
0.0	0.2	GO:0033327	Leydig cell differentiation(GO:0033327)
0.0	0.1	GO:0071277	cellular response to calcium ion(GO:0071277)
0.0	0.1	GO:1900115	sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.0	0.1	GO:0046599	regulation of centriole replication(GO:0046599)
0.0	0.0	GO:0072191	ureter smooth muscle development(GO:0072191) ureter smooth muscle cell differentiation(GO:0072193)
0.0	0.1	GO:0019934	cGMP-mediated signaling(GO:0019934)
0.0	0.0	GO:0071502	cellular response to temperature stimulus(GO:0071502)
0.0	0.2	GO:0031641	regulation of myelination(GO:0031641)
0.0	0.0	GO:0048631	regulation of skeletal muscle tissue growth(GO:0048631)
0.0	0.2	GO:0006654	phosphatidic acid biosynthetic process(GO:0006654)
0.0	0.1	GO:0046426	negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0	0.1	GO:0010815	bradykinin catabolic process(GO:0010815)
0.0	0.3	GO:0031529	ruffle organization(GO:0031529)
0.0	0.1	GO:0060666	dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.0	0.0	GO:0010996	response to auditory stimulus(GO:0010996) auditory behavior(GO:0031223)
0.0	0.1	GO:0045425	positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process(GO:0045425)
0.0	0.1	GO:0060839	endothelial cell fate commitment(GO:0060839)
0.0	0.1	GO:0006065	UDP-glucuronate biosynthetic process(GO:0006065)
0.0	0.1	GO:0032347	regulation of ketone biosynthetic process(GO:0010566) regulation of aldosterone metabolic process(GO:0032344) regulation of aldosterone biosynthetic process(GO:0032347)
0.0	0.0	GO:0060159	regulation of dopamine receptor signaling pathway(GO:0060159)
0.0	0.1	GO:0032075	positive regulation of nuclease activity(GO:0032075)
0.0	0.1	GO:0032057	negative regulation of translational initiation in response to stress(GO:0032057)
0.0	0.1	GO:0031340	positive regulation of vesicle fusion(GO:0031340)
0.0	0.1	GO:0035234	ectopic germ cell programmed cell death(GO:0035234)
0.0	0.1	GO:0048808	male genitalia morphogenesis(GO:0048808) male anatomical structure morphogenesis(GO:0090598)
0.0	0.2	GO:0060325	face morphogenesis(GO:0060325)
0.0	0.1	GO:0071379	cellular response to prostaglandin stimulus(GO:0071379)
0.0	0.3	GO:0019369	arachidonic acid metabolic process(GO:0019369)
0.0	0.1	GO:0043490	malate-aspartate shuttle(GO:0043490)
0.0	0.1	GO:0008053	mitochondrial fusion(GO:0008053)
0.0	0.1	GO:0034063	stress granule assembly(GO:0034063)
0.0	0.1	GO:0018243	protein O-linked glycosylation via serine(GO:0018242) protein O-linked glycosylation via threonine(GO:0018243)
0.0	0.2	GO:0040037	negative regulation of fibroblast growth factor receptor signaling pathway(GO:0040037)
0.0	0.1	GO:0014819	regulation of skeletal muscle contraction(GO:0014819)
0.0	0.1	GO:0009313	oligosaccharide catabolic process(GO:0009313)
0.0	0.1	GO:0032780	negative regulation of ATPase activity(GO:0032780)
0.0	0.1	GO:0034501	protein localization to kinetochore(GO:0034501)
0.0	0.1	GO:0032413	negative regulation of ion transmembrane transporter activity(GO:0032413)
0.0	0.1	GO:0046121	deoxyribonucleoside catabolic process(GO:0046121)
0.0	0.1	GO:0060040	retinal bipolar neuron differentiation(GO:0060040)
0.0	0.0	GO:0072385	minus-end-directed organelle transport along microtubule(GO:0072385)
0.0	0.1	GO:0072112	renal filtration cell differentiation(GO:0061318) glomerular epithelium development(GO:0072010) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.0	0.4	GO:0045104	intermediate filament cytoskeleton organization(GO:0045104)
0.0	0.1	GO:0097061	dendritic spine morphogenesis(GO:0060997) regulation of dendritic spine morphogenesis(GO:0061001) dendritic spine organization(GO:0097061)
0.0	0.2	GO:0007016	cytoskeletal anchoring at plasma membrane(GO:0007016)
0.0	0.3	GO:0006086	acetyl-CoA biosynthetic process from pyruvate(GO:0006086) regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510) regulation of acyl-CoA biosynthetic process(GO:0050812)
0.0	0.1	GO:0031639	plasminogen activation(GO:0031639)
0.0	0.1	GO:0042271	susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.0	0.1	GO:0050703	interleukin-1 alpha secretion(GO:0050703)
0.0	0.1	GO:0009249	protein lipoylation(GO:0009249)
0.0	0.1	GO:0034694	response to prostaglandin(GO:0034694)
0.0	0.2	GO:0032331	negative regulation of chondrocyte differentiation(GO:0032331)
0.0	0.1	GO:0071731	response to nitric oxide(GO:0071731)
0.0	0.3	GO:0035329	hippo signaling(GO:0035329)
0.0	0.1	GO:0045657	positive regulation of monocyte differentiation(GO:0045657)
0.0	0.1	GO:0001945	lymph vessel development(GO:0001945)
0.0	0.1	GO:0000103	sulfate assimilation(GO:0000103)
0.0	0.1	GO:0009886	post-embryonic morphogenesis(GO:0009886)
0.0	0.0	GO:0048702	embryonic neurocranium morphogenesis(GO:0048702)
0.0	0.1	GO:0031536	positive regulation of exit from mitosis(GO:0031536)
0.0	0.1	GO:0060055	angiogenesis involved in wound healing(GO:0060055)
0.0	0.0	GO:0060068	vagina development(GO:0060068)
0.0	0.2	GO:0034446	substrate adhesion-dependent cell spreading(GO:0034446)
0.0	0.0	GO:0009169	purine nucleoside monophosphate catabolic process(GO:0009128) ribonucleoside monophosphate catabolic process(GO:0009158) purine ribonucleoside monophosphate catabolic process(GO:0009169)
0.0	0.1	GO:0070091	glucagon secretion(GO:0070091)
0.0	0.1	GO:0007021	tubulin complex assembly(GO:0007021)
0.0	0.1	GO:0051818	disruption of cells of other organism involved in symbiotic interaction(GO:0051818) killing of cells in other organism involved in symbiotic interaction(GO:0051883)
0.0	0.1	GO:0043173	nucleotide salvage(GO:0043173)
0.0	0.1	GO:0030091	protein repair(GO:0030091)
0.0	0.1	GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
0.0	0.1	GO:0090162	establishment of epithelial cell polarity(GO:0090162)
0.0	0.1	GO:0060164	regulation of timing of neuron differentiation(GO:0060164)
0.0	0.1	GO:0009200	deoxyribonucleoside triphosphate metabolic process(GO:0009200)
0.0	0.4	GO:0016338	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.0	0.0	GO:0060584	regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
0.0	0.0	GO:0055094	response to lipoprotein particle(GO:0055094)
0.0	0.0	GO:0002023	reduction of food intake in response to dietary excess(GO:0002023)
0.0	0.0	GO:0070208	protein heterotrimerization(GO:0070208)
0.0	0.1	GO:0048625	myoblast fate commitment(GO:0048625)
0.0	0.1	GO:0051877	pigment granule aggregation in cell center(GO:0051877)
0.0	0.2	GO:0045880	positive regulation of smoothened signaling pathway(GO:0045880)
0.0	0.4	GO:0000188	inactivation of MAPK activity(GO:0000188)
0.0	0.1	GO:0009396	folic acid-containing compound biosynthetic process(GO:0009396)
0.0	0.1	GO:0032236	obsolete positive regulation of calcium ion transport via store-operated calcium channel activity(GO:0032236)
0.0	0.1	GO:0015871	choline transport(GO:0015871)
0.0	0.0	GO:0003032	detection of oxygen(GO:0003032)
0.0	0.1	GO:0051409	response to nitrosative stress(GO:0051409)
0.0	0.1	GO:0045747	positive regulation of Notch signaling pathway(GO:0045747)
0.0	0.0	GO:0001543	ovarian follicle rupture(GO:0001543)
0.0	0.1	GO:0015889	cobalamin transport(GO:0015889)
0.0	0.1	GO:0072386	plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.0	0.0	GO:0019255	glucose 1-phosphate metabolic process(GO:0019255)
0.0	0.0	GO:0008300	isoprenoid catabolic process(GO:0008300)
0.0	0.4	GO:0010811	positive regulation of cell-substrate adhesion(GO:0010811)
0.0	0.2	GO:0021772	olfactory bulb development(GO:0021772)
0.0	0.2	GO:0031532	actin cytoskeleton reorganization(GO:0031532)
0.0	0.0	GO:0009756	carbohydrate mediated signaling(GO:0009756)
0.0	0.1	GO:0043569	negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.0	0.2	GO:0048010	vascular endothelial growth factor receptor signaling pathway(GO:0048010)
0.0	0.0	GO:0003078	obsolete regulation of natriuresis(GO:0003078)
0.0	0.1	GO:0008218	bioluminescence(GO:0008218)
0.0	0.0	GO:0040016	embryonic cleavage(GO:0040016)
0.0	0.0	GO:0007621	negative regulation of female receptivity(GO:0007621)
0.0	0.0	GO:0071364	response to epidermal growth factor(GO:0070849) cellular response to epidermal growth factor stimulus(GO:0071364)
0.0	0.1	GO:0018206	peptidyl-methionine modification(GO:0018206)
0.0	0.1	GO:0006527	arginine catabolic process(GO:0006527)
0.0	0.0	GO:0002220	innate immune response activating cell surface receptor signaling pathway(GO:0002220)
0.0	0.0	GO:1901534	positive regulation of megakaryocyte differentiation(GO:0045654) positive regulation of hematopoietic progenitor cell differentiation(GO:1901534)
0.0	0.0	GO:0032493	response to bacterial lipoprotein(GO:0032493) detection of bacterial lipoprotein(GO:0042494) response to bacterial lipopeptide(GO:0070339) detection of bacterial lipopeptide(GO:0070340) cellular response to bacterial lipoprotein(GO:0071220) cellular response to bacterial lipopeptide(GO:0071221)
0.0	0.1	GO:0009415	response to water(GO:0009415)
0.0	0.1	GO:0046835	carbohydrate phosphorylation(GO:0046835)
0.0	0.3	GO:0005978	glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.0	0.2	GO:0030199	collagen fibril organization(GO:0030199)
0.0	0.1	GO:0046498	S-adenosylhomocysteine metabolic process(GO:0046498)
0.0	0.1	GO:0007528	neuromuscular junction development(GO:0007528)
0.0	0.0	GO:0032928	regulation of superoxide anion generation(GO:0032928)
0.0	0.1	GO:0051124	synaptic growth at neuromuscular junction(GO:0051124)
0.0	0.1	GO:0045989	positive regulation of striated muscle contraction(GO:0045989)
0.0	0.0	GO:0010715	regulation of extracellular matrix disassembly(GO:0010715) negative regulation of extracellular matrix disassembly(GO:0010716) regulation of extracellular matrix organization(GO:1903053) negative regulation of extracellular matrix organization(GO:1903054)
0.0	0.0	GO:0090073	positive regulation of protein homodimerization activity(GO:0090073)
0.0	0.0	GO:0001880	Mullerian duct regression(GO:0001880) anatomical structure regression(GO:0060033)
0.0	0.0	GO:0045627	positive regulation of T-helper 1 cell differentiation(GO:0045627)
0.0	0.1	GO:0032020	ISG15-protein conjugation(GO:0032020)
0.0	0.0	GO:0045578	negative regulation of B cell differentiation(GO:0045578)
0.0	0.1	GO:0033600	negative regulation of mammary gland epithelial cell proliferation(GO:0033600)
0.0	0.3	GO:0030574	collagen catabolic process(GO:0030574)
0.0	0.1	GO:0048207	vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208) COPII-coated vesicle budding(GO:0090114)
0.0	0.0	GO:0033603	positive regulation of dopamine secretion(GO:0033603)
0.0	0.1	GO:0030238	male sex determination(GO:0030238)
0.0	0.1	GO:0007520	myoblast fusion(GO:0007520)
0.0	0.0	GO:0019985	translesion synthesis(GO:0019985)
0.0	0.1	GO:0007258	JUN phosphorylation(GO:0007258)
0.0	0.0	GO:0016559	peroxisome fission(GO:0016559)
0.0	0.1	GO:0060840	artery development(GO:0060840)
0.0	0.0	GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.0	0.0	GO:0072367	regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367)
0.0	0.0	GO:0070296	sarcoplasmic reticulum calcium ion transport(GO:0070296)
0.0	0.0	GO:0031657	regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle(GO:0031657) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle(GO:0031659)
0.0	0.1	GO:0015793	glycerol transport(GO:0015793)
0.0	0.1	GO:0000101	sulfur amino acid transport(GO:0000101) L-cystine transport(GO:0015811)
0.0	0.0	GO:0009786	regulation of asymmetric cell division(GO:0009786)
0.0	0.2	GO:0015838	amino-acid betaine transport(GO:0015838) carnitine transport(GO:0015879)
0.0	0.0	GO:0061302	smooth muscle cell-matrix adhesion(GO:0061302)
0.0	0.0	GO:0006565	L-serine catabolic process(GO:0006565)
0.0	0.1	GO:0071318	cellular response to ATP(GO:0071318)
0.0	0.1	GO:0061081	positive regulation of myeloid leukocyte cytokine production involved in immune response(GO:0061081)
0.0	0.0	GO:0034638	phosphatidylcholine catabolic process(GO:0034638)
0.0	0.0	GO:0010824	regulation of centrosome duplication(GO:0010824)
0.0	0.0	GO:0046322	negative regulation of fatty acid oxidation(GO:0046322)
0.0	0.1	GO:0051016	barbed-end actin filament capping(GO:0051016)
0.0	0.1	GO:0006551	leucine metabolic process(GO:0006551)
0.0	0.1	GO:0034453	microtubule anchoring(GO:0034453)
0.0	0.0	GO:0071542	dopaminergic neuron differentiation(GO:0071542)
0.0	0.0	GO:0016266	O-glycan processing(GO:0016266)
0.0	0.1	GO:0000028	ribosomal small subunit assembly(GO:0000028)
0.0	0.0	GO:0060435	bronchiole development(GO:0060435)
0.0	0.1	GO:0009111	vitamin catabolic process(GO:0009111) fat-soluble vitamin catabolic process(GO:0042363)
0.0	0.1	GO:0050919	negative chemotaxis(GO:0050919)
0.0	0.3	GO:0071804	cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
0.0	0.0	GO:0032467	positive regulation of cytokinesis(GO:0032467)
0.0	0.0	GO:0043985	histone H4-R3 methylation(GO:0043985)
0.0	0.2	GO:0030835	negative regulation of actin filament depolymerization(GO:0030835)
0.0	0.0	GO:0001757	somite specification(GO:0001757)
0.0	0.0	GO:0021670	lateral ventricle development(GO:0021670)
0.0	0.0	GO:0070306	lens fiber cell differentiation(GO:0070306)
0.0	0.0	GO:0046185	aldehyde catabolic process(GO:0046185)
0.0	0.0	GO:0042711	maternal behavior(GO:0042711) parental behavior(GO:0060746)
0.0	0.0	GO:0060236	regulation of mitotic spindle organization(GO:0060236)
0.0	0.0	GO:0060693	regulation of branching involved in salivary gland morphogenesis(GO:0060693)
0.0	0.0	GO:0060900	optic cup morphogenesis involved in camera-type eye development(GO:0002072) embryonic camera-type eye formation(GO:0060900)
0.0	0.1	GO:0006359	regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.0	0.0	GO:0007598	blood coagulation, extrinsic pathway(GO:0007598)
0.0	0.0	GO:0060129	thyroid-stimulating hormone-secreting cell differentiation(GO:0060129)
0.0	0.1	GO:0015909	long-chain fatty acid transport(GO:0015909)
0.0	0.0	GO:0016576	histone dephosphorylation(GO:0016576)
0.0	0.0	GO:0048003	antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003)
0.0	0.1	GO:0006072	glycerol-3-phosphate metabolic process(GO:0006072)
0.0	0.2	GO:0006825	copper ion transport(GO:0006825)
0.0	0.0	GO:0015919	peroxisomal membrane transport(GO:0015919) protein import into peroxisome membrane(GO:0045046)
0.0	0.1	GO:0008045	motor neuron axon guidance(GO:0008045)
0.0	0.0	GO:0045103	intermediate filament-based process(GO:0045103)
0.0	0.0	GO:0030422	production of siRNA involved in RNA interference(GO:0030422)
0.0	0.0	GO:0042635	positive regulation of hair cycle(GO:0042635) positive regulation of hair follicle development(GO:0051798)
0.0	0.1	GO:0050746	regulation of lipoprotein metabolic process(GO:0050746)
0.0	0.1	GO:0006776	vitamin A metabolic process(GO:0006776)
0.0	0.0	GO:0055026	negative regulation of cardiac muscle tissue growth(GO:0055022) negative regulation of cardiac muscle tissue development(GO:0055026) negative regulation of cardiac muscle cell proliferation(GO:0060044) negative regulation of heart growth(GO:0061117)
0.0	0.0	GO:0042268	regulation of cytolysis(GO:0042268)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0030056	hemidesmosome(GO:0030056)
0.1	0.1	GO:0071664	catenin-TCF7L2 complex(GO:0071664)
0.1	0.2	GO:0000138	Golgi trans cisterna(GO:0000138)
0.0	0.4	GO:0017146	NMDA selective glutamate receptor complex(GO:0017146)
0.0	0.3	GO:0016342	catenin complex(GO:0016342)
0.0	0.1	GO:0031932	TORC2 complex(GO:0031932)
0.0	0.1	GO:0016327	apicolateral plasma membrane(GO:0016327)
0.0	0.2	GO:0005614	interstitial matrix(GO:0005614)
0.0	0.1	GO:0005588	collagen type V trimer(GO:0005588)
0.0	0.1	GO:0098878	ionotropic glutamate receptor complex(GO:0008328) neurotransmitter receptor complex(GO:0098878)
0.0	0.1	GO:0071437	invadopodium(GO:0071437)
0.0	0.7	GO:0001725	stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0	0.1	GO:0009331	glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.0	0.1	GO:0032059	bleb(GO:0032059)
0.0	0.1	GO:0031362	anchored component of external side of plasma membrane(GO:0031362)
0.0	0.2	GO:0030990	intraciliary transport particle(GO:0030990)
0.0	0.2	GO:0005577	fibrinogen complex(GO:0005577)
0.0	0.1	GO:0005828	kinetochore microtubule(GO:0005828)
0.0	0.1	GO:0032449	CBM complex(GO:0032449)
0.0	0.1	GO:0031232	extrinsic component of external side of plasma membrane(GO:0031232)
0.0	0.1	GO:0030934	anchoring collagen complex(GO:0030934)
0.0	0.1	GO:0002142	stereocilia coupling link(GO:0002139) stereocilia ankle link(GO:0002141) stereocilia ankle link complex(GO:0002142)
0.0	0.1	GO:0042272	nuclear RNA export factor complex(GO:0042272)
0.0	0.1	GO:0098647	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0	0.1	GO:0016442	RISC complex(GO:0016442) RNAi effector complex(GO:0031332)
0.0	0.2	GO:0098651	basement membrane collagen trimer(GO:0098651)
0.0	0.2	GO:0030315	T-tubule(GO:0030315)
0.0	0.1	GO:0030121	AP-1 adaptor complex(GO:0030121)
0.0	0.1	GO:0044291	intercalated disc(GO:0014704) cell-cell contact zone(GO:0044291)
0.0	0.1	GO:0031092	platelet alpha granule membrane(GO:0031092)
0.0	0.5	GO:0008305	integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.0	0.0	GO:0043083	synaptic cleft(GO:0043083)
0.0	0.1	GO:0030122	AP-2 adaptor complex(GO:0030122) clathrin coat of endocytic vesicle(GO:0030128)
0.0	0.0	GO:0071942	XPC complex(GO:0071942)
0.0	0.3	GO:0005811	lipid particle(GO:0005811)
0.0	0.0	GO:0071062	alphav-beta3 integrin-vitronectin complex(GO:0071062)
0.0	0.1	GO:0005663	DNA replication factor C complex(GO:0005663)
0.0	0.1	GO:0005579	membrane attack complex(GO:0005579)
0.0	0.2	GO:0012507	ER to Golgi transport vesicle membrane(GO:0012507)
0.0	0.1	GO:0032588	trans-Golgi network membrane(GO:0032588)
0.0	0.1	GO:0017119	Golgi transport complex(GO:0017119)
0.0	0.1	GO:0042587	glycogen granule(GO:0042587)
0.0	0.0	GO:0030134	ER to Golgi transport vesicle(GO:0030134)
0.0	0.0	GO:0008282	ATP-sensitive potassium channel complex(GO:0008282)
0.0	0.2	GO:0009925	basal plasma membrane(GO:0009925)
0.0	0.0	GO:0071256	Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.0	0.0	GO:0036126	outer dense fiber(GO:0001520) sperm flagellum(GO:0036126)
0.0	0.1	GO:0046930	pore complex(GO:0046930)
0.0	0.1	GO:0031430	M band(GO:0031430)
0.0	0.1	GO:0098644	complex of collagen trimers(GO:0098644)
0.0	0.0	GO:0005863	striated muscle myosin thick filament(GO:0005863)
0.0	0.6	GO:0030496	midbody(GO:0030496)
0.0	0.1	GO:0070652	HAUS complex(GO:0070652)
0.0	0.1	GO:0005671	Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.5	GO:0005173	stem cell factor receptor binding(GO:0005173)
0.1	0.4	GO:0051371	muscle alpha-actinin binding(GO:0051371)
0.1	0.3	GO:0005006	epidermal growth factor-activated receptor activity(GO:0005006)
0.1	0.3	GO:0005010	insulin-like growth factor-activated receptor activity(GO:0005010)
0.1	0.3	GO:0048027	mRNA 5'-UTR binding(GO:0048027)
0.1	0.2	GO:0004322	ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.1	0.2	GO:0050508	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.0	0.4	GO:0017166	vinculin binding(GO:0017166)
0.0	0.3	GO:0004969	histamine receptor activity(GO:0004969)
0.0	0.1	GO:0004948	calcitonin receptor activity(GO:0004948)
0.0	0.3	GO:0042153	obsolete RPTP-like protein binding(GO:0042153)
0.0	0.1	GO:0004720	protein-lysine 6-oxidase activity(GO:0004720)
0.0	0.2	GO:0004597	peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.0	0.1	GO:0045236	CXCR chemokine receptor binding(GO:0045236)
0.0	0.4	GO:0051010	microtubule plus-end binding(GO:0051010)
0.0	0.2	GO:0048406	nerve growth factor binding(GO:0048406)
0.0	0.3	GO:0004908	interleukin-1 receptor activity(GO:0004908)
0.0	0.1	GO:0030297	transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.0	0.1	GO:0004117	calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117)
0.0	0.1	GO:0003680	AT DNA binding(GO:0003680)
0.0	0.2	GO:0004862	cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0	0.2	GO:0008046	axon guidance receptor activity(GO:0008046)
0.0	0.2	GO:0003785	actin monomer binding(GO:0003785)
0.0	0.1	GO:0047499	calcium-independent phospholipase A2 activity(GO:0047499)
0.0	0.1	GO:0033829	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.0	0.2	GO:0005021	vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0	0.1	GO:0070052	collagen V binding(GO:0070052)
0.0	0.1	GO:0042805	actinin binding(GO:0042805)
0.0	0.4	GO:0015269	calcium-activated potassium channel activity(GO:0015269)
0.0	0.2	GO:0005172	vascular endothelial growth factor receptor binding(GO:0005172)
0.0	0.1	GO:0004157	dihydropyrimidinase activity(GO:0004157)
0.0	0.1	GO:0035184	histone threonine kinase activity(GO:0035184)
0.0	0.2	GO:0005499	vitamin D binding(GO:0005499)
0.0	0.1	GO:0015556	C4-dicarboxylate transmembrane transporter activity(GO:0015556)
0.0	0.1	GO:0016901	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor(GO:0016901)
0.0	0.1	GO:0008321	Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0	0.1	GO:0045499	chemorepellent activity(GO:0045499)
0.0	0.3	GO:0004065	arylsulfatase activity(GO:0004065)
0.0	0.1	GO:0050543	icosatetraenoic acid binding(GO:0050543)
0.0	0.1	GO:0043539	protein serine/threonine kinase activator activity(GO:0043539)
0.0	0.1	GO:0045569	TRAIL binding(GO:0045569)
0.0	0.1	GO:0070576	vitamin D 24-hydroxylase activity(GO:0070576)
0.0	0.2	GO:0070717	poly-purine tract binding(GO:0070717)
0.0	0.1	GO:0030172	troponin C binding(GO:0030172)
0.0	0.1	GO:0015288	porin activity(GO:0015288)
0.0	0.7	GO:0017137	Rab GTPase binding(GO:0017137)
0.0	0.2	GO:0051879	Hsp90 protein binding(GO:0051879)
0.0	0.2	GO:0005072	transforming growth factor beta receptor, cytoplasmic mediator activity(GO:0005072)
0.0	0.1	GO:0015220	choline transmembrane transporter activity(GO:0015220)
0.0	0.1	GO:0050656	3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
0.0	0.5	GO:0050840	extracellular matrix binding(GO:0050840)
0.0	0.1	GO:0004477	methenyltetrahydrofolate cyclohydrolase activity(GO:0004477)
0.0	0.1	GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.0	0.1	GO:0005114	type II transforming growth factor beta receptor binding(GO:0005114)
0.0	0.1	GO:0055077	gap junction hemi-channel activity(GO:0055077)
0.0	0.1	GO:0046912	transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.0	0.2	GO:0005523	tropomyosin binding(GO:0005523)
0.0	0.1	GO:0003689	DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0	0.1	GO:0005110	frizzled-2 binding(GO:0005110)
0.0	0.1	GO:0004738	pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.0	0.1	GO:0016509	long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0016509)
0.0	0.1	GO:0033743	peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.0	0.1	GO:0004687	myosin light chain kinase activity(GO:0004687)
0.0	0.2	GO:0047372	acylglycerol lipase activity(GO:0047372)
0.0	0.1	GO:0015277	kainate selective glutamate receptor activity(GO:0015277)
0.0	0.1	GO:0017080	sodium channel regulator activity(GO:0017080)
0.0	0.1	GO:0034618	arginine binding(GO:0034618)
0.0	0.1	GO:0032052	bile acid binding(GO:0032052)
0.0	0.1	GO:0051636	obsolete Gram-negative bacterial cell surface binding(GO:0051636)
0.0	0.2	GO:0008139	nuclear localization sequence binding(GO:0008139)
0.0	0.1	GO:0016802	adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0	0.1	GO:0005432	calcium:sodium antiporter activity(GO:0005432)
0.0	0.1	GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717)
0.0	0.1	GO:0003708	retinoic acid receptor activity(GO:0003708)
0.0	0.2	GO:0070403	NAD+ binding(GO:0070403)
0.0	0.0	GO:0016909	JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0	0.1	GO:0005078	MAP-kinase scaffold activity(GO:0005078)
0.0	0.0	GO:0032794	GTPase activating protein binding(GO:0032794)
0.0	0.2	GO:0043498	obsolete cell surface binding(GO:0043498)
0.0	0.1	GO:0031210	phosphatidylcholine binding(GO:0031210)
0.0	0.1	GO:0003706	obsolete ligand-regulated transcription factor activity(GO:0003706)
0.0	0.1	GO:0055106	ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106)
0.0	0.1	GO:0048407	platelet-derived growth factor binding(GO:0048407)
0.0	0.0	GO:0030215	semaphorin receptor binding(GO:0030215)
0.0	0.0	GO:0016623	oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor(GO:0016623)
0.0	0.0	GO:0016941	natriuretic peptide receptor activity(GO:0016941)
0.0	0.0	GO:0004924	oncostatin-M receptor activity(GO:0004924)
0.0	0.0	GO:0050501	hyaluronan synthase activity(GO:0050501)
0.0	0.0	GO:0004321	fatty-acyl-CoA synthase activity(GO:0004321)
0.0	0.4	GO:0005518	collagen binding(GO:0005518)
0.0	0.1	GO:0004791	thioredoxin-disulfide reductase activity(GO:0004791)
0.0	0.1	GO:0008484	sulfuric ester hydrolase activity(GO:0008484)
0.0	0.0	GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.0	0.1	GO:0070290	N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0	0.1	GO:0045294	alpha-catenin binding(GO:0045294)
0.0	0.1	GO:0035035	histone acetyltransferase binding(GO:0035035)
0.0	0.1	GO:0004128	cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.0	0.1	GO:0005315	inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0	0.0	GO:0005534	galactose binding(GO:0005534)
0.0	0.1	GO:0044548	S100 protein binding(GO:0044548)
0.0	0.3	GO:0004364	glutathione transferase activity(GO:0004364)
0.0	0.0	GO:0043398	HLH domain binding(GO:0043398)
0.0	0.1	GO:0052743	inositol tetrakisphosphate phosphatase activity(GO:0052743)
0.0	0.1	GO:0015184	L-cystine transmembrane transporter activity(GO:0015184)
0.0	0.0	GO:0019797	procollagen-proline 3-dioxygenase activity(GO:0019797) peptidyl-proline 3-dioxygenase activity(GO:0031544)
0.0	0.0	GO:0004594	pantothenate kinase activity(GO:0004594)
0.0	0.1	GO:0016813	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.0	0.0	GO:0017089	glycolipid transporter activity(GO:0017089)
0.0	0.0	GO:0000309	nicotinamide-nucleotide adenylyltransferase activity(GO:0000309) nicotinate-nucleotide adenylyltransferase activity(GO:0004515)
0.0	0.1	GO:0042605	peptide antigen binding(GO:0042605)
0.0	0.0	GO:0005294	neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.0	0.0	GO:0004516	nicotinate phosphoribosyltransferase activity(GO:0004516)
0.0	0.0	GO:0048039	ubiquinone binding(GO:0048039)
0.0	0.1	GO:0017091	AU-rich element binding(GO:0017091)
0.0	0.1	GO:0043422	protein kinase B binding(GO:0043422)
0.0	0.1	GO:0042056	chemoattractant activity(GO:0042056)
0.0	0.0	GO:0005017	platelet-derived growth factor-activated receptor activity(GO:0005017)
0.0	0.2	GO:0004653	polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0	0.0	GO:0042799	histone methyltransferase activity (H4-K20 specific)(GO:0042799)
0.0	0.1	GO:0008271	secondary active sulfate transmembrane transporter activity(GO:0008271)
0.0	0.0	GO:0005229	intracellular calcium activated chloride channel activity(GO:0005229)
0.0	0.1	GO:0005536	glucose binding(GO:0005536)
0.0	0.1	GO:0000339	RNA cap binding(GO:0000339)
0.0	0.1	GO:0030274	LIM domain binding(GO:0030274)
0.0	0.0	GO:0008331	high voltage-gated calcium channel activity(GO:0008331)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.4	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
0.1	PID ECADHERIN KERATINOCYTE PATHWAY	E-cadherin signaling in keratinocytes
1.0	PID UPA UPAR PATHWAY	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.7	PID INTEGRIN3 PATHWAY	Beta3 integrin cell surface interactions
0.0	PID BETA CATENIN DEG PATHWAY	Degradation of beta catenin
0.1	PID S1P S1P2 PATHWAY	S1P2 pathway
0.1	PID VEGFR1 2 PATHWAY	Signaling events mediated by VEGFR1 and VEGFR2
0.2	PID HEDGEHOG 2PATHWAY	Signaling events mediated by the Hedgehog family
0.1	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.2	PID CIRCADIAN PATHWAY	Circadian rhythm pathway
0.5	NABA COLLAGENS	Genes encoding collagen proteins
0.0	ST IL 13 PATHWAY	Interleukin 13 (IL-13) Pathway
0.1	PID HDAC CLASSII PATHWAY	Signaling events mediated by HDAC Class II
0.0	PID FAK PATHWAY	Signaling events mediated by focal adhesion kinase
0.0	PID A6B1 A6B4 INTEGRIN PATHWAY	a6b1 and a6b4 Integrin signaling
0.0	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
0.6	PID TGFBR PATHWAY	TGF-beta receptor signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.1	REACTOME PI3K AKT ACTIVATION	Genes involved in PI3K/AKT activation
0.0	0.5	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.0	0.1	REACTOME PD1 SIGNALING	Genes involved in PD-1 signaling
0.0	0.0	REACTOME KERATAN SULFATE KERATIN METABOLISM	Genes involved in Keratan sulfate/keratin metabolism
0.0	0.3	REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0	0.0	REACTOME RNA POL I PROMOTER OPENING	Genes involved in RNA Polymerase I Promoter Opening
0.0	0.3	REACTOME PRE NOTCH PROCESSING IN GOLGI	Genes involved in Pre-NOTCH Processing in Golgi
0.0	0.0	REACTOME OPSINS	Genes involved in Opsins
0.0	0.2	REACTOME GAP JUNCTION DEGRADATION	Genes involved in Gap junction degradation
0.0	0.5	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.0	0.0	REACTOME ALPHA LINOLENIC ACID ALA METABOLISM	Genes involved in alpha-linolenic acid (ALA) metabolism
0.0	0.0	REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION	Genes involved in Influenza Viral RNA Transcription and Replication
0.0	0.0	REACTOME NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Neurotransmitter Release Cycle
0.0	0.4	REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION	Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0	0.0	REACTOME SOS MEDIATED SIGNALLING	Genes involved in SOS-mediated signalling
0.0	0.2	REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0	0.2	REACTOME ACTIVATION OF GENES BY ATF4	Genes involved in Activation of Genes by ATF4
0.0	0.1	REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS	Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0	0.2	REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS	Genes involved in Tandem pore domain potassium channels
0.0	0.0	REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP	Genes involved in Destabilization of mRNA by Tristetraprolin (TTP)
0.0	0.1	REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Dopamine Neurotransmitter Release Cycle
0.0	0.8	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.0	0.2	REACTOME THE ACTIVATION OF ARYLSULFATASES	Genes involved in The activation of arylsulfatases
0.0	0.1	REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII	Genes involved in CREB phosphorylation through the activation of CaMKII
0.0	0.1	REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	Genes involved in Ionotropic activity of Kainate Receptors
0.0	0.3	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.0	0.7	REACTOME INTEGRIN CELL SURFACE INTERACTIONS	Genes involved in Integrin cell surface interactions
0.0	0.1	REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR	Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0	0.4	REACTOME TIGHT JUNCTION INTERACTIONS	Genes involved in Tight junction interactions
0.0	0.1	REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE	Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0	0.5	REACTOME NETRIN1 SIGNALING	Genes involved in Netrin-1 signaling
0.0	0.2	REACTOME SIGNALING BY BMP	Genes involved in Signaling by BMP
0.0	0.1	REACTOME CRMPS IN SEMA3A SIGNALING	Genes involved in CRMPs in Sema3A signaling
0.0	0.4	REACTOME AMINE LIGAND BINDING RECEPTORS	Genes involved in Amine ligand-binding receptors
0.0	0.2	REACTOME GRB2 EVENTS IN ERBB2 SIGNALING	Genes involved in GRB2 events in ERBB2 signaling
0.0	0.1	REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS	Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0	0.1	REACTOME PURINE CATABOLISM	Genes involved in Purine catabolism
0.0	0.1	REACTOME DESTABILIZATION OF MRNA BY BRF1	Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.0	0.1	REACTOME G2 M DNA DAMAGE CHECKPOINT	Genes involved in G2/M DNA damage checkpoint
0.0	0.1	REACTOME SIGNALLING TO P38 VIA RIT AND RIN	Genes involved in Signalling to p38 via RIT and RIN