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ENCODE: H3K4me1 ChIP-Seq of primary human cells
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Results for PDX1

Z-value: 0.84

Motif logo

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Transcription factors associated with PDX1

Gene Symbol Gene ID Gene Info
PDX1
ENSG00000139515.5 pancreatic and duodenal homeobox 1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr13_28491302_28491453PDX127800.210847-0.771.6e-02Click!
chr13_28492869_28493020PDX112130.386310-0.589.8e-02Click!
chr13_28491766_28492143PDX122030.242018-0.442.3e-01Click!
chr13_28493501_28493652PDX15810.661953-0.432.5e-01Click!
chr13_28492279_28492430PDX118030.279266-0.422.5e-01Click!

Activity of the PDX1 motif across conditions

Conditions sorted by the z-value of the PDX1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr7_46949633_46949784 0.73 AC011294.3
 Uncharacterized protein
 212988
 0.03
chr16_17931428_17931579 0.73 XYLT1
 xylosyltransferase I
 366765
 0.01
chr5_39411390_39411705 0.59 DAB2
 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
 13423
 0.26
chr7_17412244_17412395 0.59 ENSG00000199473
 .
 631
 0.81
chr18_72443447_72443598 0.58 ZNF407
 zinc finger protein 407
 100546
 0.08
chr8_118960048_118960199 0.52 EXT1
 exostosin glycosyltransferase 1
 162530
 0.04
chr3_156478754_156479058 0.51 LEKR1
 leucine, glutamate and lysine rich 1
 65183
 0.12
chr2_65008994_65009145 0.50 ENSG00000253082
 .
 5831
 0.22
chr5_77886942_77887093 0.45 LHFPL2
 lipoma HMGIC fusion partner-like 2
 42043
 0.21
chr1_31870163_31870721 0.45 SERINC2
 serine incorporator 2
 11970
 0.15
chr9_4137653_4137928 0.45 GLIS3
 GLIS family zinc finger 3
 7403
 0.28
chr13_24782132_24782457 0.43 SPATA13
 spermatogenesis associated 13
 43538
 0.13
chr2_19237763_19237914 0.43 ENSG00000266738
 .
 310352
 0.01
chr3_45521797_45522168 0.42 LARS2-AS1
 LARS2 antisense RNA 1
 29055
 0.2
chr9_124161266_124161489 0.42 RP11-162D16.2
23858
 0.15
chr7_24741561_24741712 0.40 DFNA5
 deafness, autosomal dominant 5
 4209
 0.34
chr12_95597054_95597379 0.40 FGD6
 FYVE, RhoGEF and PH domain containing 6
 13939
 0.18
chr10_78923339_78923671 0.40 RP11-180I22.2
15455
 0.25
chr15_90392195_90392442 0.39 ENSG00000264966
 .
 1635
 0.26
chr1_109740426_109740857 0.39 ENSG00000238310
 .
 9829
 0.15
chr5_14264414_14265476 0.38 TRIO
 trio Rho guanine nucleotide exchange factor
 26141
 0.27
chr6_10085176_10085327 0.38 OFCC1
 orofacial cleft 1 candidate 1
 29756
 0.25
chr5_17282736_17283060 0.37 ENSG00000252908
 .
 42178
 0.15
chr7_101457741_101458764 0.37 CUX1
 cut-like homeobox 1
 707
 0.73
chr10_23114375_23114526 0.37 ENSG00000206842
 .
 38128
 0.19
chr16_67439717_67439868 0.37 ZDHHC1
 zinc finger, DHHC-type containing 1
 4898
 0.11
chr5_39072103_39073220 0.36 RICTOR
 RPTOR independent companion of MTOR, complex 2
 1830
 0.43
chr11_34997556_34998012 0.36 PDHX
 pyruvate dehydrogenase complex, component X
 1547
 0.44
chr10_63603062_63603213 0.36 ARID5B
 AT rich interactive domain 5B (MRF1-like)
 57922
 0.14
chr4_24553435_24554115 0.36 ENSG00000243005
 .
 11309
 0.21
chr8_59742095_59742246 0.36 ENSG00000201231
 .
 15059
 0.28
chr13_76867098_76867386 0.36 ENSG00000243274
 .
 158175
 0.04
chr14_54574129_54574280 0.35 BMP4
 bone morphogenetic protein 4
 148725
 0.04
chr6_56534653_56534887 0.35 DST
 dystonin
 26976
 0.25
chr10_6763840_6763991 0.35 PRKCQ
 protein kinase C, theta
 141652
 0.05
chr3_81793119_81793296 0.35 GBE1
 glucan (1,4-alpha-), branching enzyme 1
 427
 0.92
chr6_132082478_132082629 0.35 ENSG00000266807
 .
 30759
 0.14
chr11_126456164_126456315 0.35 KIRREL3-AS1
 KIRREL3 antisense RNA 1
 42397
 0.16
chr3_81777594_81777815 0.34 GBE1
 glucan (1,4-alpha-), branching enzyme 1
 15076
 0.31
chr3_11254129_11254425 0.34 HRH1
 histamine receptor H1
 13440
 0.26
chr2_224966339_224966634 0.34 SERPINE2
 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
 62450
 0.13
chr10_102761652_102761861 0.34 LZTS2
 leucine zipper, putative tumor suppressor 2
 2146
 0.16
chr1_221872835_221873035 0.34 DUSP10
 dual specificity phosphatase 10
 37867
 0.23
chr1_196578004_196578155 0.34 KCNT2
 potassium channel, subfamily T, member 2
 276
 0.93
chr6_113660616_113660767 0.33 ENSG00000222677
 .
 175498
 0.03
chr10_52085009_52085183 0.33 AC069547.1
 HCG1745369; PRO3073; Uncharacterized protein
 9202
 0.2
chr5_149679633_149679784 0.33 ARSI
 arylsulfatase family, member I
 2808
 0.25
chr3_58369457_58369608 0.33 PXK
 PX domain containing serine/threonine kinase
 11869
 0.19
chr1_59289424_59289575 0.33 JUN
 jun proto-oncogene
 39714
 0.18
chr1_100110656_100110807 0.33 PALMD
 palmdelphin
 768
 0.75
chr6_81163819_81163970 0.33 BCKDHB
 branched chain keto acid dehydrogenase E1, beta polypeptide
 347511
 0.01
chr13_102102047_102102198 0.32 ITGBL1
 integrin, beta-like 1 (with EGF-like repeat domains)
 2844
 0.36
chr18_71856871_71857022 0.32 TIMM21
 translocase of inner mitochondrial membrane 21 homolog (yeast)
 34536
 0.16
chr12_124476513_124476664 0.32 ZNF664
 zinc finger protein 664
 18746
 0.08
chr2_224683617_224683768 0.32 AP1S3
 adaptor-related protein complex 1, sigma 3 subunit
 18509
 0.26
chr17_64419641_64419918 0.32 RP11-4F22.2
6807
 0.26
chr9_118837376_118837527 0.32 PAPPA
 pregnancy-associated plasma protein A, pappalysin 1
 78632
 0.11
chr18_45560087_45560238 0.32 ZBTB7C
 zinc finger and BTB domain containing 7C
 7332
 0.29
chr8_54780688_54780839 0.32 RP11-1070A24.2
8446
 0.18
chr17_53804440_53804591 0.32 TMEM100
 transmembrane protein 100
 4298
 0.29
chr8_129798902_129799053 0.32 ENSG00000221351
 .
 33063
 0.25
chr7_29028937_29029088 0.32 AC005162.5
2368
 0.31
chr5_150024876_150025027 0.32 SYNPO
 synaptopodin
 4711
 0.16
chr1_180549413_180549564 0.31 ENSG00000266683
 .
 34520
 0.16
chr17_64297527_64298255 0.31 PRKCA
 protein kinase C, alpha
 1053
 0.55
chr12_110493934_110494306 0.31 C12orf76
 chromosome 12 open reading frame 76
 7030
 0.2
chr11_108487825_108487976 0.31 EXPH5
 exophilin 5
 23435
 0.21
chr2_205530356_205530507 0.31 PARD3B
 par-3 family cell polarity regulator beta
 119708
 0.07
chr17_60074998_60075962 0.31 ENSG00000242398
 .
 7868
 0.17
chr7_151297372_151297523 0.31 PRKAG2
 protein kinase, AMP-activated, gamma 2 non-catalytic subunit
 31992
 0.18
chr20_13781196_13781347 0.31 NDUFAF5
 NADH dehydrogenase (ubiquinone) complex I, assembly factor 5
 15575
 0.22
chr4_87260645_87260796 0.31 ENSG00000252757
 .
 2953
 0.32
chr13_33836579_33836730 0.31 ENSG00000236581
 .
 8862
 0.23
chr4_54425031_54425364 0.31 LNX1
 ligand of numb-protein X 1, E3 ubiquitin protein ligase
 813
 0.67
chr10_30388154_30388305 0.31 KIAA1462
 KIAA1462
 39776
 0.21
chr4_75072940_75073180 0.31 AC093677.1
 Uncharacterized protein
 48975
 0.12
chr5_95415281_95415432 0.31 ENSG00000207578
 .
 514
 0.85
chr7_33020923_33021074 0.31 FKBP9
 FK506 binding protein 9, 63 kDa
 1887
 0.3
chr20_10844545_10844731 0.30 RP11-103J8.1
38294
 0.22
chr10_99995580_99995731 0.30 RP11-34A14.3
16125
 0.21
chr18_12742991_12743142 0.30 ENSG00000201466
 .
 17650
 0.15
chr4_95454799_95455193 0.30 PDLIM5
 PDZ and LIM domain 5
 10120
 0.32
chr17_48124722_48124974 0.30 ITGA3
 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
 8491
 0.14
chrX_16861423_16861574 0.30 RBBP7
 retinoblastoma binding protein 7
 8690
 0.18
chr11_66799605_66799756 0.30 SYT12
 synaptotagmin XII
 4649
 0.16
chr3_156025423_156025574 0.30 KCNAB1
 potassium voltage-gated channel, shaker-related subfamily, beta member 1
 15801
 0.26
chr4_182873147_182873298 0.30 ENSG00000251742
 .
 116961
 0.06
chr11_107433298_107433449 0.30 ALKBH8
 alkB, alkylation repair homolog 8 (E. coli)
 2871
 0.27
chr9_115317323_115317474 0.30 C9orf147
 chromosome 9 open reading frame 147
 67914
 0.11
chr11_1580523_1580674 0.30 DUSP8
 dual specificity phosphatase 8
 6568
 0.13
chr18_415803_416022 0.30 RP11-720L2.2
8504
 0.25
chr3_188668964_188669115 0.30 TPRG1
 tumor protein p63 regulated 1
 4036
 0.37
chr5_77190041_77190192 0.30 TBCA
 tubulin folding cofactor A
 25512
 0.25
chr15_59560424_59560575 0.30 RP11-429D19.1
2862
 0.21
chr2_216326541_216326692 0.30 AC012462.1
25640
 0.2
chr4_74571517_74571668 0.30 IL8
 interleukin 8
 34631
 0.18
chr22_26717807_26718076 0.30 SEZ6L
 seizure related 6 homolog (mouse)-like
 25740
 0.18
chr10_112083656_112083807 0.29 SMNDC1
 survival motor neuron domain containing 1
 19022
 0.23
chr9_125146729_125146880 0.29 AL162424.1
 Uncharacterized protein
 2124
 0.22
chr12_52837042_52837193 0.29 KRT6B
 keratin 6B
 8793
 0.1
chr10_100076549_100076804 0.29 LOXL4
 lysyl oxidase-like 4
 48669
 0.13
chr1_85163731_85163882 0.29 SSX2IP
 synovial sarcoma, X breakpoint 2 interacting protein
 7320
 0.25
chr2_192168870_192169021 0.29 MYO1B
 myosin IB
 27334
 0.22
chr3_172038302_172038563 0.29 AC092964.1
 Uncharacterized protein
 4214
 0.26
chr2_228735932_228736236 0.29 DAW1
 dynein assembly factor with WDR repeat domains 1
 239
 0.94
chr20_11120768_11120919 0.29 C20orf187
 chromosome 20 open reading frame 187
 112032
 0.07
chr9_109952511_109952662 0.29 RP11-508N12.2
87317
 0.09
chr14_35169641_35169792 0.29 CFL2
 cofilin 2 (muscle)
 13318
 0.18
chr1_95440168_95440319 0.29 RP4-639F20.1
13362
 0.2
chr4_16252476_16252627 0.29 TAPT1-AS1
 TAPT1 antisense RNA 1 (head to head)
 23883
 0.19
chr3_189655319_189655470 0.29 ENSG00000216058
 .
 107683
 0.07
chr8_126291633_126291784 0.29 ENSG00000242170
 .
 8862
 0.26
chr3_177463007_177463158 0.29 ENSG00000200288
 .
 120885
 0.06
chr1_240507937_240508088 0.29 ENSG00000252317
 .
 3327
 0.31
chr7_16168760_16168911 0.29 ISPD-AS1
 ISPD antisense RNA 1
 81278
 0.11
chr12_16504068_16504219 0.29 MGST1
 microsomal glutathione S-transferase 1
 463
 0.87
chr13_107160759_107160952 0.29 EFNB2
 ephrin-B2
 26607
 0.24
chr17_16281825_16281976 0.29 UBB
 ubiquitin B
 2212
 0.22
chr11_108564488_108564639 0.28 DDX10
 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
 28714
 0.23
chr2_159866696_159866847 0.28 ENSG00000202029
 .
 16883
 0.21
chr4_129309196_129309347 0.28 PGRMC2
 progesterone receptor membrane component 2
 99287
 0.09
chr2_97452558_97452709 0.28 CNNM4
 cyclin M4
 1689
 0.29
chr13_46066295_46066446 0.28 COG3
 component of oligomeric golgi complex 3
 27310
 0.17
chr1_236046467_236046618 0.28 LYST
 lysosomal trafficking regulator
 330
 0.87
chr1_215039039_215039190 0.28 KCNK2
 potassium channel, subfamily K, member 2
 140084
 0.05
chr3_27367738_27367889 0.28 NEK10
 NIMA-related kinase 10
 34765
 0.16
chr11_8928681_8928832 0.28 ST5
 suppression of tumorigenicity 5
 3742
 0.13
chr6_11767541_11767692 0.28 ADTRP
 androgen-dependent TFPI-regulating protein
 11420
 0.27
chr22_27816562_27816713 0.28 RP11-375H17.1
295831
 0.01
chr1_85064390_85064541 0.28 CTBS
 chitobiase, di-N-acetyl-
 24318
 0.17
chr9_38039342_38039926 0.28 SHB
 Src homology 2 domain containing adaptor protein B
 29574
 0.21
chr11_58941542_58941693 0.28 DTX4
 deltex homolog 4 (Drosophila)
 1652
 0.33
chr12_15879564_15879715 0.28 EPS8
 epidermal growth factor receptor pathway substrate 8
 1560
 0.5
chr16_84210184_84210335 0.28 DNAAF1
 dynein, axonemal, assembly factor 1
 512
 0.67
chr5_110725476_110725627 0.28 CTC-499J9.1
87286
 0.08
chr19_43356290_43356490 0.27 PSG10P
 pregnancy specific beta-1-glycoprotein 10, pseudogene
 3381
 0.21
chr14_91090982_91091133 0.27 TTC7B
 tetratricopeptide repeat domain 7B
 6690
 0.2
chr5_73463660_73463811 0.27 ENSG00000222551
 .
 103855
 0.08
chr9_127072608_127072759 0.27 NEK6
 NIMA-related kinase 6
 10419
 0.19
chr11_106239373_106239524 0.27 RP11-680E19.1
104406
 0.08
chr11_33712841_33713004 0.27 RP4-541C22.5
5325
 0.18
chr1_230222948_230223099 0.27 GALNT2
 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 (GalNAc-T2)
 20005
 0.23
chr17_79855827_79855978 0.27 NPB
 neuropeptide B
 2719
 0.08
chr1_185066313_185066464 0.27 TRMT1L
 tRNA methyltransferase 1 homolog (S. cerevisiae)-like
 42304
 0.13
chr6_48743198_48743349 0.27 ENSG00000221175
 .
 74287
 0.13
chr14_76289523_76289812 0.27 RP11-270M14.4
13887
 0.25
chr19_43392666_43392817 0.27 PSG1
 pregnancy specific beta-1-glycoprotein 1
 8870
 0.17
chr10_128556488_128556639 0.27 DOCK1
 dedicator of cytokinesis 1
 37415
 0.18
chr7_127410389_127410540 0.27 SND1
 staphylococcal nuclease and tudor domain containing 1
 117501
 0.05
chr1_3230129_3230570 0.27 PRDM16
 PR domain containing 16
 69653
 0.11
chr10_17261059_17261210 0.27 VIM-AS1
 VIM antisense RNA 1
 7763
 0.16
chr11_75269832_75269983 0.27 SERPINH1
 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
 3194
 0.18
chr13_106835108_106835518 0.27 ENSG00000222682
 .
 27474
 0.23
chr1_183851401_183851702 0.27 COLGALT2
 collagen beta(1-O)galactosyltransferase 2
 64201
 0.12
chr19_43652929_43653080 0.27 PSG5
 pregnancy specific beta-1-glycoprotein 5
 37638
 0.14
chr1_156232399_156232550 0.27 PAQR6
 progestin and adipoQ receptor family member VI
 14593
 0.09
chr15_34415216_34415367 0.27 PGBD4
 piggyBac transposable element derived 4
 21017
 0.15
chr5_36374010_36374366 0.27 RANBP3L
 RAN binding protein 3-like
 71972
 0.11
chr4_151494582_151494735 0.27 RP11-1336O20.2
5583
 0.24
chr5_123737339_123737490 0.27 RP11-436H11.2
327110
 0.01
chr20_10502069_10502225 0.27 SLX4IP
 SLX4 interacting protein
 86196
 0.09
chr20_59830581_59830732 0.27 CDH4
 cadherin 4, type 1, R-cadherin (retinal)
 3174
 0.41
chr16_48444372_48444523 0.27 ENSG00000265077
 .
 4242
 0.18
chr8_41053658_41053809 0.26 ENSG00000263372
 .
 74929
 0.09
chr4_90040818_90040969 0.26 TIGD2
 tigger transposable element derived 2
 6925
 0.23
chr10_89436229_89436444 0.26 PAPSS2
 3'-phosphoadenosine 5'-phosphosulfate synthase 2
 15628
 0.19
chr14_103480838_103481545 0.26 CDC42BPB
 CDC42 binding protein kinase beta (DMPK-like)
 42608
 0.12
chr14_42609922_42610073 0.26 ENSG00000222084
 .
 159957
 0.04
chr1_219259694_219259888 0.26 LYPLAL1
 lysophospholipase-like 1
 87395
 0.1
chr17_53812177_53812328 0.26 TMEM100
 transmembrane protein 100
 2770
 0.34
chr1_15355114_15355265 0.26 KAZN
 kazrin, periplakin interacting protein
 82774
 0.1
chr3_111522709_111522860 0.26 PHLDB2
 pleckstrin homology-like domain, family B, member 2
 55243
 0.14
chr5_17223674_17224319 0.26 BASP1
 brain abundant, membrane attached signal protein 1
 6327
 0.19
chr16_86806268_86806419 0.26 FOXL1
 forkhead box L1
 194228
 0.03
chr13_100776751_100776902 0.26 PCCA
 propionyl CoA carboxylase, alpha polypeptide
 35489
 0.21
chr13_31367185_31367336 0.26 ALOX5AP
 arachidonate 5-lipoxygenase-activating protein
 57615
 0.14
chr6_79325243_79325394 0.26 IRAK1BP1
 interleukin-1 receptor-associated kinase 1 binding protein 1
 251871
 0.02
chr8_36738584_36738735 0.26 KCNU1
 potassium channel, subfamily U, member 1
 47764
 0.19
chr11_29315204_29315355 0.26 ENSG00000211499
 .
 17043
 0.31
chr6_25230157_25230308 0.26 ENSG00000264238
 .
 26751
 0.14
chr9_17004159_17004310 0.26 ENSG00000241152
 .
 49665
 0.18
chr10_125793430_125793581 0.26 CHST15
 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
 12736
 0.27
chr7_90013217_90013368 0.26 CLDN12
 claudin 12
 257
 0.93
chr17_41496073_41496238 0.26 ENSG00000251763
 .
 6360
 0.12
chr7_32201162_32201313 0.26 PDE1C
 phosphodiesterase 1C, calmodulin-dependent 70kDa
 90189
 0.1
chr5_167156903_167157054 0.25 CTB-78F1.2
8610
 0.23
chr7_55132299_55132450 0.25 EGFR
 epidermal growth factor receptor
 45042
 0.19
chr1_178244906_178245188 0.25 RASAL2
 RAS protein activator like 2
 65559
 0.14
chr1_196150065_196150216 0.25 ENSG00000265986
 .
 401471
 0.01
chr11_102722401_102722552 0.25 MMP3
 matrix metallopeptidase 3 (stromelysin 1, progelatinase)
 7942
 0.19
chr4_128619906_128620188 0.25 INTU
 inturned planar cell polarity protein
 11078
 0.23
chr2_56148778_56148929 0.25 EFEMP1
 EGF containing fibulin-like extracellular matrix protein 1
 1503
 0.42
chr10_20218216_20218367 0.25 PLXDC2
 plexin domain containing 2
 113123
 0.06
chr6_1798322_1798473 0.25 FOXC1
 forkhead box C1
 187716
 0.03
chr1_86020329_86020665 0.25 DDAH1
 dimethylarginine dimethylaminohydrolase 1
 23436
 0.17
chr3_139905404_139905555 0.25 ENSG00000263959
 .
 216783
 0.02
chr17_17912103_17912254 0.25 LRRC48
 leucine rich repeat containing 48
 1840
 0.25
chr12_6292503_6292996 0.25 CD9
 CD9 molecule
 16132
 0.18
chr12_102461670_102461821 0.25 RP11-554E23.4
4612
 0.2
chr8_41906632_41907752 0.25 KAT6A
 K(lysine) acetyltransferase 6A
 2313
 0.3

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of PDX1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0048149 behavioral response to ethanol(GO:0048149)
0.1 0.3 GO:0032509 endosome transport via multivesicular body sorting pathway(GO:0032509)
0.1 0.1 GO:0060028 convergent extension involved in axis elongation(GO:0060028)
0.1 0.2 GO:0021827 cerebral cortex tangential migration using cell-cell interactions(GO:0021823) substrate-dependent cerebral cortex tangential migration(GO:0021825) postnatal olfactory bulb interneuron migration(GO:0021827)
0.1 0.3 GO:0051497 negative regulation of stress fiber assembly(GO:0051497)
0.1 0.2 GO:0007386 compartment pattern specification(GO:0007386)
0.1 0.1 GO:0002541 activation of plasma proteins involved in acute inflammatory response(GO:0002541)
0.1 0.1 GO:0019372 lipoxygenase pathway(GO:0019372)
0.1 0.2 GO:0043589 skin morphogenesis(GO:0043589)
0.1 0.2 GO:0070254 mucus secretion(GO:0070254)
0.1 0.3 GO:0000301 retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.0 0.2 GO:2000095 regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000095)
0.0 0.1 GO:0071436 sodium ion export(GO:0071436)
0.0 0.1 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.0 0.1 GO:0044415 evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.0 0.1 GO:0060083 smooth muscle contraction involved in micturition(GO:0060083)
0.0 0.1 GO:0060831 smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:0060831)
0.0 0.4 GO:0033137 negative regulation of peptidyl-serine phosphorylation(GO:0033137)
0.0 0.3 GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0 0.4 GO:0009629 response to gravity(GO:0009629)
0.0 0.1 GO:0010766 negative regulation of sodium ion transport(GO:0010766)
0.0 0.2 GO:0070141 response to UV-A(GO:0070141)
0.0 0.1 GO:0047484 regulation of response to osmotic stress(GO:0047484)
0.0 0.1 GO:0061430 bone trabecula formation(GO:0060346) bone trabecula morphogenesis(GO:0061430)
0.0 0.1 GO:2000143 negative regulation of transcription initiation from RNA polymerase II promoter(GO:0060633) negative regulation of DNA-templated transcription, initiation(GO:2000143)
0.0 0.1 GO:0001778 plasma membrane repair(GO:0001778)
0.0 0.1 GO:0010936 negative regulation of macrophage cytokine production(GO:0010936)
0.0 0.1 GO:0010757 negative regulation of plasminogen activation(GO:0010757)
0.0 0.1 GO:0032898 neurotrophin production(GO:0032898)
0.0 0.2 GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.0 0.1 GO:0010193 response to ozone(GO:0010193)
0.0 0.1 GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.0 0.3 GO:0060390 regulation of SMAD protein import into nucleus(GO:0060390)
0.0 0.1 GO:0030505 inorganic diphosphate transport(GO:0030505)
0.0 0.1 GO:0010837 regulation of keratinocyte proliferation(GO:0010837)
0.0 0.1 GO:0051305 chromosome movement towards spindle pole(GO:0051305)
0.0 0.1 GO:0022605 oogenesis stage(GO:0022605)
0.0 0.1 GO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.0 0.1 GO:0030538 embryonic genitalia morphogenesis(GO:0030538)
0.0 0.4 GO:0050930 induction of positive chemotaxis(GO:0050930)
0.0 0.2 GO:0060638 mesenchymal-epithelial cell signaling(GO:0060638)
0.0 0.2 GO:0033327 Leydig cell differentiation(GO:0033327)
0.0 0.1 GO:0071277 cellular response to calcium ion(GO:0071277)
0.0 0.1 GO:1900115 sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.0 0.1 GO:0046599 regulation of centriole replication(GO:0046599)
0.0 0.0 GO:0072191 ureter smooth muscle development(GO:0072191) ureter smooth muscle cell differentiation(GO:0072193)
0.0 0.1 GO:0019934 cGMP-mediated signaling(GO:0019934)
0.0 0.0 GO:0071502 cellular response to temperature stimulus(GO:0071502)
0.0 0.2 GO:0031641 regulation of myelination(GO:0031641)
0.0 0.0 GO:0048631 regulation of skeletal muscle tissue growth(GO:0048631)
0.0 0.2 GO:0006654 phosphatidic acid biosynthetic process(GO:0006654)
0.0 0.1 GO:0046426 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0 0.1 GO:0010815 bradykinin catabolic process(GO:0010815)
0.0 0.3 GO:0031529 ruffle organization(GO:0031529)
0.0 0.1 GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.0 0.0 GO:0010996 response to auditory stimulus(GO:0010996) auditory behavior(GO:0031223)
0.0 0.1 GO:0045425 positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process(GO:0045425)
0.0 0.1 GO:0060839 endothelial cell fate commitment(GO:0060839)
0.0 0.1 GO:0006065 UDP-glucuronate biosynthetic process(GO:0006065)
0.0 0.1 GO:0032347 regulation of ketone biosynthetic process(GO:0010566) regulation of aldosterone metabolic process(GO:0032344) regulation of aldosterone biosynthetic process(GO:0032347)
0.0 0.0 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.0 0.1 GO:0032075 positive regulation of nuclease activity(GO:0032075)
0.0 0.1 GO:0032057 negative regulation of translational initiation in response to stress(GO:0032057)
0.0 0.1 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
0.0 0.1 GO:0035234 ectopic germ cell programmed cell death(GO:0035234)
0.0 0.1 GO:0048808 male genitalia morphogenesis(GO:0048808) male anatomical structure morphogenesis(GO:0090598)
0.0 0.2 GO:0060325 face morphogenesis(GO:0060325)
0.0 0.1 GO:0071379 cellular response to prostaglandin stimulus(GO:0071379)
0.0 0.3 GO:0019369 arachidonic acid metabolic process(GO:0019369)
0.0 0.1 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.0 0.1 GO:0008053 mitochondrial fusion(GO:0008053)
0.0 0.1 GO:0034063 stress granule assembly(GO:0034063)
0.0 0.1 GO:0018243 protein O-linked glycosylation via serine(GO:0018242) protein O-linked glycosylation via threonine(GO:0018243)
0.0 0.2 GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway(GO:0040037)
0.0 0.1 GO:0014819 regulation of skeletal muscle contraction(GO:0014819)
0.0 0.1 GO:0009313 oligosaccharide catabolic process(GO:0009313)
0.0 0.1 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.0 0.1 GO:0034501 protein localization to kinetochore(GO:0034501)
0.0 0.1 GO:0032413 negative regulation of ion transmembrane transporter activity(GO:0032413)
0.0 0.1 GO:0046121 deoxyribonucleoside catabolic process(GO:0046121)
0.0 0.1 GO:0060040 retinal bipolar neuron differentiation(GO:0060040)
0.0 0.0 GO:0072385 minus-end-directed organelle transport along microtubule(GO:0072385)
0.0 0.1 GO:0072112 renal filtration cell differentiation(GO:0061318) glomerular epithelium development(GO:0072010) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.0 0.4 GO:0045104 intermediate filament cytoskeleton organization(GO:0045104)
0.0 0.1 GO:0097061 dendritic spine morphogenesis(GO:0060997) regulation of dendritic spine morphogenesis(GO:0061001) dendritic spine organization(GO:0097061)
0.0 0.2 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
0.0 0.3 GO:0006086 acetyl-CoA biosynthetic process from pyruvate(GO:0006086) regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510) regulation of acyl-CoA biosynthetic process(GO:0050812)
0.0 0.1 GO:0031639 plasminogen activation(GO:0031639)
0.0 0.1 GO:0042271 susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.0 0.1 GO:0050703 interleukin-1 alpha secretion(GO:0050703)
0.0 0.1 GO:0009249 protein lipoylation(GO:0009249)
0.0 0.1 GO:0034694 response to prostaglandin(GO:0034694)
0.0 0.2 GO:0032331 negative regulation of chondrocyte differentiation(GO:0032331)
0.0 0.1 GO:0071731 response to nitric oxide(GO:0071731)
0.0 0.3 GO:0035329 hippo signaling(GO:0035329)
0.0 0.1 GO:0045657 positive regulation of monocyte differentiation(GO:0045657)
0.0 0.1 GO:0001945 lymph vessel development(GO:0001945)
0.0 0.1 GO:0000103 sulfate assimilation(GO:0000103)
0.0 0.1 GO:0009886 post-embryonic morphogenesis(GO:0009886)
0.0 0.0 GO:0048702 embryonic neurocranium morphogenesis(GO:0048702)
0.0 0.1 GO:0031536 positive regulation of exit from mitosis(GO:0031536)
0.0 0.1 GO:0060055 angiogenesis involved in wound healing(GO:0060055)
0.0 0.0 GO:0060068 vagina development(GO:0060068)
0.0 0.2 GO:0034446 substrate adhesion-dependent cell spreading(GO:0034446)
0.0 0.0 GO:0009169 purine nucleoside monophosphate catabolic process(GO:0009128) ribonucleoside monophosphate catabolic process(GO:0009158) purine ribonucleoside monophosphate catabolic process(GO:0009169)
0.0 0.1 GO:0070091 glucagon secretion(GO:0070091)
0.0 0.1 GO:0007021 tubulin complex assembly(GO:0007021)
0.0 0.1 GO:0051818 disruption of cells of other organism involved in symbiotic interaction(GO:0051818) killing of cells in other organism involved in symbiotic interaction(GO:0051883)
0.0 0.1 GO:0043173 nucleotide salvage(GO:0043173)
0.0 0.1 GO:0030091 protein repair(GO:0030091)
0.0 0.1 GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
0.0 0.1 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.0 0.1 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.0 0.1 GO:0009200 deoxyribonucleoside triphosphate metabolic process(GO:0009200)
0.0 0.4 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.0 0.0 GO:0060584 regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
0.0 0.0 GO:0055094 response to lipoprotein particle(GO:0055094)
0.0 0.0 GO:0002023 reduction of food intake in response to dietary excess(GO:0002023)
0.0 0.0 GO:0070208 protein heterotrimerization(GO:0070208)
0.0 0.1 GO:0048625 myoblast fate commitment(GO:0048625)
0.0 0.1 GO:0051877 pigment granule aggregation in cell center(GO:0051877)
0.0 0.2 GO:0045880 positive regulation of smoothened signaling pathway(GO:0045880)
0.0 0.4 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.0 0.1 GO:0009396 folic acid-containing compound biosynthetic process(GO:0009396)
0.0 0.1 GO:0032236 obsolete positive regulation of calcium ion transport via store-operated calcium channel activity(GO:0032236)
0.0 0.1 GO:0015871 choline transport(GO:0015871)
0.0 0.0 GO:0003032 detection of oxygen(GO:0003032)
0.0 0.1 GO:0051409 response to nitrosative stress(GO:0051409)
0.0 0.1 GO:0045747 positive regulation of Notch signaling pathway(GO:0045747)
0.0 0.0 GO:0001543 ovarian follicle rupture(GO:0001543)
0.0 0.1 GO:0015889 cobalamin transport(GO:0015889)
0.0 0.1 GO:0072386 plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.0 0.0 GO:0019255 glucose 1-phosphate metabolic process(GO:0019255)
0.0 0.0 GO:0008300 isoprenoid catabolic process(GO:0008300)
0.0 0.4 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.0 0.2 GO:0021772 olfactory bulb development(GO:0021772)
0.0 0.2 GO:0031532 actin cytoskeleton reorganization(GO:0031532)
0.0 0.0 GO:0009756 carbohydrate mediated signaling(GO:0009756)
0.0 0.1 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.0 0.2 GO:0048010 vascular endothelial growth factor receptor signaling pathway(GO:0048010)
0.0 0.0 GO:0003078 obsolete regulation of natriuresis(GO:0003078)
0.0 0.1 GO:0008218 bioluminescence(GO:0008218)
0.0 0.0 GO:0040016 embryonic cleavage(GO:0040016)
0.0 0.0 GO:0007621 negative regulation of female receptivity(GO:0007621)
0.0 0.0 GO:0071364 response to epidermal growth factor(GO:0070849) cellular response to epidermal growth factor stimulus(GO:0071364)
0.0 0.1 GO:0018206 peptidyl-methionine modification(GO:0018206)
0.0 0.1 GO:0006527 arginine catabolic process(GO:0006527)
0.0 0.0 GO:0002220 innate immune response activating cell surface receptor signaling pathway(GO:0002220)
0.0 0.0 GO:1901534 positive regulation of megakaryocyte differentiation(GO:0045654) positive regulation of hematopoietic progenitor cell differentiation(GO:1901534)
0.0 0.0 GO:0032493 response to bacterial lipoprotein(GO:0032493) detection of bacterial lipoprotein(GO:0042494) response to bacterial lipopeptide(GO:0070339) detection of bacterial lipopeptide(GO:0070340) cellular response to bacterial lipoprotein(GO:0071220) cellular response to bacterial lipopeptide(GO:0071221)
0.0 0.1 GO:0009415 response to water(GO:0009415)
0.0 0.1 GO:0046835 carbohydrate phosphorylation(GO:0046835)
0.0 0.3 GO:0005978 glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.0 0.2 GO:0030199 collagen fibril organization(GO:0030199)
0.0 0.1 GO:0046498 S-adenosylhomocysteine metabolic process(GO:0046498)
0.0 0.1 GO:0007528 neuromuscular junction development(GO:0007528)
0.0 0.0 GO:0032928 regulation of superoxide anion generation(GO:0032928)
0.0 0.1 GO:0051124 synaptic growth at neuromuscular junction(GO:0051124)
0.0 0.1 GO:0045989 positive regulation of striated muscle contraction(GO:0045989)
0.0 0.0 GO:0010715 regulation of extracellular matrix disassembly(GO:0010715) negative regulation of extracellular matrix disassembly(GO:0010716) regulation of extracellular matrix organization(GO:1903053) negative regulation of extracellular matrix organization(GO:1903054)
0.0 0.0 GO:0090073 positive regulation of protein homodimerization activity(GO:0090073)
0.0 0.0 GO:0001880 Mullerian duct regression(GO:0001880) anatomical structure regression(GO:0060033)
0.0 0.0 GO:0045627 positive regulation of T-helper 1 cell differentiation(GO:0045627)
0.0 0.1 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.0 0.0 GO:0045578 negative regulation of B cell differentiation(GO:0045578)
0.0 0.1 GO:0033600 negative regulation of mammary gland epithelial cell proliferation(GO:0033600)
0.0 0.3 GO:0030574 collagen catabolic process(GO:0030574)
0.0 0.1 GO:0048207 vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208) COPII-coated vesicle budding(GO:0090114)
0.0 0.0 GO:0033603 positive regulation of dopamine secretion(GO:0033603)
0.0 0.1 GO:0030238 male sex determination(GO:0030238)
0.0 0.1 GO:0007520 myoblast fusion(GO:0007520)
0.0 0.0 GO:0019985 translesion synthesis(GO:0019985)
0.0 0.1 GO:0007258 JUN phosphorylation(GO:0007258)
0.0 0.0 GO:0016559 peroxisome fission(GO:0016559)
0.0 0.1 GO:0060840 artery development(GO:0060840)
0.0 0.0 GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.0 0.0 GO:0072367 regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367)
0.0 0.0 GO:0070296 sarcoplasmic reticulum calcium ion transport(GO:0070296)
0.0 0.0 GO:0031657 regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle(GO:0031657) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle(GO:0031659)
0.0 0.1 GO:0015793 glycerol transport(GO:0015793)
0.0 0.1 GO:0000101 sulfur amino acid transport(GO:0000101) L-cystine transport(GO:0015811)
0.0 0.0 GO:0009786 regulation of asymmetric cell division(GO:0009786)
0.0 0.2 GO:0015838 amino-acid betaine transport(GO:0015838) carnitine transport(GO:0015879)
0.0 0.0 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.0 0.0 GO:0006565 L-serine catabolic process(GO:0006565)
0.0 0.1 GO:0071318 cellular response to ATP(GO:0071318)
0.0 0.1 GO:0061081 positive regulation of myeloid leukocyte cytokine production involved in immune response(GO:0061081)
0.0 0.0 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.0 0.0 GO:0010824 regulation of centrosome duplication(GO:0010824)
0.0 0.0 GO:0046322 negative regulation of fatty acid oxidation(GO:0046322)
0.0 0.1 GO:0051016 barbed-end actin filament capping(GO:0051016)
0.0 0.1 GO:0006551 leucine metabolic process(GO:0006551)
0.0 0.1 GO:0034453 microtubule anchoring(GO:0034453)
0.0 0.0 GO:0071542 dopaminergic neuron differentiation(GO:0071542)
0.0 0.0 GO:0016266 O-glycan processing(GO:0016266)
0.0 0.1 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.0 0.0 GO:0060435 bronchiole development(GO:0060435)
0.0 0.1 GO:0009111 vitamin catabolic process(GO:0009111) fat-soluble vitamin catabolic process(GO:0042363)
0.0 0.1 GO:0050919 negative chemotaxis(GO:0050919)
0.0 0.3 GO:0071804 cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
0.0 0.0 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 0.0 GO:0043985 histone H4-R3 methylation(GO:0043985)
0.0 0.2 GO:0030835 negative regulation of actin filament depolymerization(GO:0030835)
0.0 0.0 GO:0001757 somite specification(GO:0001757)
0.0 0.0 GO:0021670 lateral ventricle development(GO:0021670)
0.0 0.0 GO:0070306 lens fiber cell differentiation(GO:0070306)
0.0 0.0 GO:0046185 aldehyde catabolic process(GO:0046185)
0.0 0.0 GO:0042711 maternal behavior(GO:0042711) parental behavior(GO:0060746)
0.0 0.0 GO:0060236 regulation of mitotic spindle organization(GO:0060236)
0.0 0.0 GO:0060693 regulation of branching involved in salivary gland morphogenesis(GO:0060693)
0.0 0.0 GO:0060900 optic cup morphogenesis involved in camera-type eye development(GO:0002072) embryonic camera-type eye formation(GO:0060900)
0.0 0.1 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.0 0.0 GO:0007598 blood coagulation, extrinsic pathway(GO:0007598)
0.0 0.0 GO:0060129 thyroid-stimulating hormone-secreting cell differentiation(GO:0060129)
0.0 0.1 GO:0015909 long-chain fatty acid transport(GO:0015909)
0.0 0.0 GO:0016576 histone dephosphorylation(GO:0016576)
0.0 0.0 GO:0048003 antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003)
0.0 0.1 GO:0006072 glycerol-3-phosphate metabolic process(GO:0006072)
0.0 0.2 GO:0006825 copper ion transport(GO:0006825)
0.0 0.0 GO:0015919 peroxisomal membrane transport(GO:0015919) protein import into peroxisome membrane(GO:0045046)
0.0 0.1 GO:0008045 motor neuron axon guidance(GO:0008045)
0.0 0.0 GO:0045103 intermediate filament-based process(GO:0045103)
0.0 0.0 GO:0030422 production of siRNA involved in RNA interference(GO:0030422)
0.0 0.0 GO:0042635 positive regulation of hair cycle(GO:0042635) positive regulation of hair follicle development(GO:0051798)
0.0 0.1 GO:0050746 regulation of lipoprotein metabolic process(GO:0050746)
0.0 0.1 GO:0006776 vitamin A metabolic process(GO:0006776)
0.0 0.0 GO:0055026 negative regulation of cardiac muscle tissue growth(GO:0055022) negative regulation of cardiac muscle tissue development(GO:0055026) negative regulation of cardiac muscle cell proliferation(GO:0060044) negative regulation of heart growth(GO:0061117)
0.0 0.0 GO:0042268 regulation of cytolysis(GO:0042268)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0030056 hemidesmosome(GO:0030056)
0.1 0.1 GO:0071664 catenin-TCF7L2 complex(GO:0071664)
0.1 0.2 GO:0000138 Golgi trans cisterna(GO:0000138)
0.0 0.4 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.3 GO:0016342 catenin complex(GO:0016342)
0.0 0.1 GO:0031932 TORC2 complex(GO:0031932)
0.0 0.1 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.2 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.1 GO:0005588 collagen type V trimer(GO:0005588)
0.0 0.1 GO:0098878 ionotropic glutamate receptor complex(GO:0008328) neurotransmitter receptor complex(GO:0098878)
0.0 0.1 GO:0071437 invadopodium(GO:0071437)
0.0 0.7 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 0.1 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.0 0.1 GO:0032059 bleb(GO:0032059)
0.0 0.1 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 0.2 GO:0030990 intraciliary transport particle(GO:0030990)
0.0 0.2 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.1 GO:0005828 kinetochore microtubule(GO:0005828)
0.0 0.1 GO:0032449 CBM complex(GO:0032449)
0.0 0.1 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.0 0.1 GO:0030934 anchoring collagen complex(GO:0030934)
0.0 0.1 GO:0002142 stereocilia coupling link(GO:0002139) stereocilia ankle link(GO:0002141) stereocilia ankle link complex(GO:0002142)
0.0 0.1 GO:0042272 nuclear RNA export factor complex(GO:0042272)
0.0 0.1 GO:0098647 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0 0.1 GO:0016442 RISC complex(GO:0016442) RNAi effector complex(GO:0031332)
0.0 0.2 GO:0098651 basement membrane collagen trimer(GO:0098651)
0.0 0.2 GO:0030315 T-tubule(GO:0030315)
0.0 0.1 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.0 0.1 GO:0044291 intercalated disc(GO:0014704) cell-cell contact zone(GO:0044291)
0.0 0.1 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.5 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.0 0.0 GO:0043083 synaptic cleft(GO:0043083)
0.0 0.1 GO:0030122 AP-2 adaptor complex(GO:0030122) clathrin coat of endocytic vesicle(GO:0030128)
0.0 0.0 GO:0071942 XPC complex(GO:0071942)
0.0 0.3 GO:0005811 lipid particle(GO:0005811)
0.0 0.0 GO:0071062 alphav-beta3 integrin-vitronectin complex(GO:0071062)
0.0 0.1 GO:0005663 DNA replication factor C complex(GO:0005663)
0.0 0.1 GO:0005579 membrane attack complex(GO:0005579)
0.0 0.2 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.0 0.1 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 0.1 GO:0017119 Golgi transport complex(GO:0017119)
0.0 0.1 GO:0042587 glycogen granule(GO:0042587)
0.0 0.0 GO:0030134 ER to Golgi transport vesicle(GO:0030134)
0.0 0.0 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.0 0.2 GO:0009925 basal plasma membrane(GO:0009925)
0.0 0.0 GO:0071256 Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.0 0.0 GO:0036126 outer dense fiber(GO:0001520) sperm flagellum(GO:0036126)
0.0 0.1 GO:0046930 pore complex(GO:0046930)
0.0 0.1 GO:0031430 M band(GO:0031430)
0.0 0.1 GO:0098644 complex of collagen trimers(GO:0098644)
0.0 0.0 GO:0005863 striated muscle myosin thick filament(GO:0005863)
0.0 0.6 GO:0030496 midbody(GO:0030496)
0.0 0.1 GO:0070652 HAUS complex(GO:0070652)
0.0 0.1 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.1 0.4 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.1 0.3 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.1 0.3 GO:0005010 insulin-like growth factor-activated receptor activity(GO:0005010)
0.1 0.3 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.1 0.2 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.1 0.2 GO:0050508 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.0 0.4 GO:0017166 vinculin binding(GO:0017166)
0.0 0.3 GO:0004969 histamine receptor activity(GO:0004969)
0.0 0.1 GO:0004948 calcitonin receptor activity(GO:0004948)
0.0 0.3 GO:0042153 obsolete RPTP-like protein binding(GO:0042153)
0.0 0.1 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.0 0.2 GO:0004597 peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.0 0.1 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.0 0.4 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.2 GO:0048406 nerve growth factor binding(GO:0048406)
0.0 0.3 GO:0004908 interleukin-1 receptor activity(GO:0004908)
0.0 0.1 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.0 0.1 GO:0004117 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117)
0.0 0.1 GO:0003680 AT DNA binding(GO:0003680)
0.0 0.2 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0 0.2 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 0.2 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.1 GO:0047499 calcium-independent phospholipase A2 activity(GO:0047499)
0.0 0.1 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.0 0.2 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0 0.1 GO:0070052 collagen V binding(GO:0070052)
0.0 0.1 GO:0042805 actinin binding(GO:0042805)
0.0 0.4 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.0 0.2 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.0 0.1 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.0 0.1 GO:0035184 histone threonine kinase activity(GO:0035184)
0.0 0.2 GO:0005499 vitamin D binding(GO:0005499)
0.0 0.1 GO:0015556 C4-dicarboxylate transmembrane transporter activity(GO:0015556)
0.0 0.1 GO:0016901 oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor(GO:0016901)
0.0 0.1 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0 0.1 GO:0045499 chemorepellent activity(GO:0045499)
0.0 0.3 GO:0004065 arylsulfatase activity(GO:0004065)
0.0 0.1 GO:0050543 icosatetraenoic acid binding(GO:0050543)
0.0 0.1 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 0.1 GO:0045569 TRAIL binding(GO:0045569)
0.0 0.1 GO:0070576 vitamin D 24-hydroxylase activity(GO:0070576)
0.0 0.2 GO:0070717 poly-purine tract binding(GO:0070717)
0.0 0.1 GO:0030172 troponin C binding(GO:0030172)
0.0 0.1 GO:0015288 porin activity(GO:0015288)
0.0 0.7 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 0.2 GO:0051879 Hsp90 protein binding(GO:0051879)
0.0 0.2 GO:0005072 transforming growth factor beta receptor, cytoplasmic mediator activity(GO:0005072)
0.0 0.1 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.0 0.1 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
0.0 0.5 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 0.1 GO:0004477 methenyltetrahydrofolate cyclohydrolase activity(GO:0004477)
0.0 0.1 GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.0 0.1 GO:0005114 type II transforming growth factor beta receptor binding(GO:0005114)
0.0 0.1 GO:0055077 gap junction hemi-channel activity(GO:0055077)
0.0 0.1 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.0 0.2 GO:0005523 tropomyosin binding(GO:0005523)
0.0 0.1 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0 0.1 GO:0005110 frizzled-2 binding(GO:0005110)
0.0 0.1 GO:0004738 pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.0 0.1 GO:0016509 long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0016509)
0.0 0.1 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.0 0.1 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.0 0.2 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.1 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.0 0.1 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 0.1 GO:0034618 arginine binding(GO:0034618)
0.0 0.1 GO:0032052 bile acid binding(GO:0032052)
0.0 0.1 GO:0051636 obsolete Gram-negative bacterial cell surface binding(GO:0051636)
0.0 0.2 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 0.1 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0 0.1 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.0 0.1 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717)
0.0 0.1 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.0 0.2 GO:0070403 NAD+ binding(GO:0070403)
0.0 0.0 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0 0.1 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.0 0.0 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 0.2 GO:0043498 obsolete cell surface binding(GO:0043498)
0.0 0.1 GO:0031210 phosphatidylcholine binding(GO:0031210)
0.0 0.1 GO:0003706 obsolete ligand-regulated transcription factor activity(GO:0003706)
0.0 0.1 GO:0055106 ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106)
0.0 0.1 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 0.0 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.0 GO:0016623 oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor(GO:0016623)
0.0 0.0 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.0 0.0 GO:0004924 oncostatin-M receptor activity(GO:0004924)
0.0 0.0 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.0 0.0 GO:0004321 fatty-acyl-CoA synthase activity(GO:0004321)
0.0 0.4 GO:0005518 collagen binding(GO:0005518)
0.0 0.1 GO:0004791 thioredoxin-disulfide reductase activity(GO:0004791)
0.0 0.1 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
0.0 0.0 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.0 0.1 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0 0.1 GO:0045294 alpha-catenin binding(GO:0045294)
0.0 0.1 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 0.1 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.0 0.1 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0 0.0 GO:0005534 galactose binding(GO:0005534)
0.0 0.1 GO:0044548 S100 protein binding(GO:0044548)
0.0 0.3 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 0.0 GO:0043398 HLH domain binding(GO:0043398)
0.0 0.1 GO:0052743 inositol tetrakisphosphate phosphatase activity(GO:0052743)
0.0 0.1 GO:0015184 L-cystine transmembrane transporter activity(GO:0015184)
0.0 0.0 GO:0019797 procollagen-proline 3-dioxygenase activity(GO:0019797) peptidyl-proline 3-dioxygenase activity(GO:0031544)
0.0 0.0 GO:0004594 pantothenate kinase activity(GO:0004594)
0.0 0.1 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.0 0.0 GO:0017089 glycolipid transporter activity(GO:0017089)
0.0 0.0 GO:0000309 nicotinamide-nucleotide adenylyltransferase activity(GO:0000309) nicotinate-nucleotide adenylyltransferase activity(GO:0004515)
0.0 0.1 GO:0042605 peptide antigen binding(GO:0042605)
0.0 0.0 GO:0005294 neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.0 0.0 GO:0004516 nicotinate phosphoribosyltransferase activity(GO:0004516)
0.0 0.0 GO:0048039 ubiquinone binding(GO:0048039)
0.0 0.1 GO:0017091 AU-rich element binding(GO:0017091)
0.0 0.1 GO:0043422 protein kinase B binding(GO:0043422)
0.0 0.1 GO:0042056 chemoattractant activity(GO:0042056)
0.0 0.0 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017)
0.0 0.2 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.0 GO:0042799 histone methyltransferase activity (H4-K20 specific)(GO:0042799)
0.0 0.1 GO:0008271 secondary active sulfate transmembrane transporter activity(GO:0008271)
0.0 0.0 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.0 0.1 GO:0005536 glucose binding(GO:0005536)
0.0 0.1 GO:0000339 RNA cap binding(GO:0000339)
0.0 0.1 GO:0030274 LIM domain binding(GO:0030274)
0.0 0.0 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.0 0.1 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.0 1.0 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 0.7 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions
0.0 0.0 PID BETA CATENIN DEG PATHWAY Degradation of beta catenin
0.0 0.1 PID S1P S1P2 PATHWAY S1P2 pathway
0.0 0.1 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.0 0.2 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.1 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 0.2 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 0.5 NABA COLLAGENS Genes encoding collagen proteins
0.0 0.0 ST IL 13 PATHWAY Interleukin 13 (IL-13) Pathway
0.0 0.1 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.0 0.0 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.0 0.0 PID A6B1 A6B4 INTEGRIN PATHWAY a6b1 and a6b4 Integrin signaling
0.0 0.0 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.6 PID TGFBR PATHWAY TGF-beta receptor signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.1 REACTOME PI3K AKT ACTIVATION Genes involved in PI3K/AKT activation
0.0 0.5 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.1 REACTOME PD1 SIGNALING Genes involved in PD-1 signaling
0.0 0.0 REACTOME KERATAN SULFATE KERATIN METABOLISM Genes involved in Keratan sulfate/keratin metabolism
0.0 0.3 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 0.0 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 0.3 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.0 REACTOME OPSINS Genes involved in Opsins
0.0 0.2 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.0 0.5 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.0 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.0 0.0 REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION Genes involved in Influenza Viral RNA Transcription and Replication
0.0 0.0 REACTOME NEUROTRANSMITTER RELEASE CYCLE Genes involved in Neurotransmitter Release Cycle
0.0 0.4 REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0 0.0 REACTOME SOS MEDIATED SIGNALLING Genes involved in SOS-mediated signalling
0.0 0.2 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.2 REACTOME ACTIVATION OF GENES BY ATF4 Genes involved in Activation of Genes by ATF4
0.0 0.1 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 0.2 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 0.0 REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP Genes involved in Destabilization of mRNA by Tristetraprolin (TTP)
0.0 0.1 REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.0 0.8 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.2 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 0.1 REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.0 0.1 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.3 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.7 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 0.1 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0 0.4 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 0.1 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0 0.5 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 0.2 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 0.1 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 0.4 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.0 0.2 REACTOME GRB2 EVENTS IN ERBB2 SIGNALING Genes involved in GRB2 events in ERBB2 signaling
0.0 0.1 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.1 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.0 0.1 REACTOME DESTABILIZATION OF MRNA BY BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.0 0.1 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.0 0.1 REACTOME SIGNALLING TO P38 VIA RIT AND RIN Genes involved in Signalling to p38 via RIT and RIN