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ENCODE: H3K4me1 ChIP-Seq of primary human cells

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Results for PITX2

Z-value: 2.34

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Transcription factors associated with PITX2

Gene Symbol	Gene ID	Gene Info
PITX2 Ensembl NCBI GeneCards UniProt	ENSG00000164093.11	paired like homeodomain 2

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
chr4_111553963_111554114	PITX2	4138	0.334821	0.67	4.7e-02	Click!
chr4_111553080_111553232	PITX2	5020	0.318769	0.62	7.7e-02	Click!
chr4_111540192_111540343	PITX2	3940	0.334575	0.62	7.7e-02	Click!
chr4_111542090_111542446	PITX2	1939	0.462145	0.60	8.5e-02	Click!
chr4_111543717_111543960	PITX2	369	0.920240	0.47	2.0e-01	Click!

Activity of the PITX2 motif across conditions

Conditions sorted by the z-value of the PITX2 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr18_29621846_29622219	0.55	ENSG00000265063	.	18920	0.13
chr20_3093091_3093363	0.54	UBOX5-AS1	UBOX5 antisense RNA 1	1944	0.22
chr17_73778576_73778846	0.52	UNK	unkempt family zinc finger	1970	0.15
chr7_139942100_139942354	0.50	ENSG00000199283	.	557	0.76
chr5_75745118_75745695	0.49	IQGAP2	IQ motif containing GTPase activating protein 2	45157	0.18
chr1_40426744_40426895	0.49	MFSD2A	major facilitator superfamily domain containing 2A	5997	0.17
chr20_55975594_55975873	0.48	RP4-800J21.3		7615	0.16
chr7_73641803_73642005	0.47	LAT2	linker for activation of T cells family, member 2	17551	0.14
chr3_107781222_107781468	0.46	CD47	CD47 molecule	2966	0.4
chr7_5573288_5573527	0.45	ACTB	actin, beta	3067	0.16
chr8_130971634_130971785	0.45	FAM49B	family with sequence similarity 49, member B	11509	0.2
chr10_89826192_89826568	0.44	ENSG00000200891	.	71928	0.12
chr1_92928100_92928251	0.44	GFI1	growth factor independent 1 transcription repressor	21336	0.22
chr10_6134499_6134864	0.44	RBM17	RNA binding motif protein 17	3372	0.2
chr12_31985428_31985587	0.43	ENSG00000252204	.	21485	0.16
chr16_81553923_81554074	0.43	CMIP	c-Maf inducing protein	25044	0.24
chr2_42331828_42332250	0.42	PKDCC	protein kinase domain containing, cytoplasmic	56879	0.12
chr8_145053399_145053643	0.42	PLEC	plectin	2619	0.14
chr20_47415297_47415458	0.42	PREX1	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1	29043	0.21
chr16_50737166_50737317	0.42	NOD2	nucleotide-binding oligomerization domain containing 2	6191	0.12
chr1_169661653_169661807	0.42	SELL	selectin L	19109	0.18
chr13_41930416_41930674	0.41	ENSG00000223280	.	1750	0.37
chr1_23859431_23859804	0.41	E2F2	E2F transcription factor 2	1905	0.32
chr4_170000682_170000833	0.41	RP11-483A20.3		69176	0.1
chr5_79441431_79441595	0.40	CTC-458I2.2		17329	0.2
chr17_17180986_17181137	0.40	COPS3	COP9 signalosome subunit 3	2953	0.2
chr1_39313333_39313484	0.40	RRAGC	Ras-related GTP binding C	12087	0.15
chr1_12240101_12240252	0.40	ENSG00000263676	.	11594	0.15
chr2_70367797_70368219	0.40	C2orf42	chromosome 2 open reading frame 42	41119	0.11
chr8_41999804_41999957	0.39	RP11-589C21.5		10401	0.17
chr17_28050844_28051306	0.39	RP11-82O19.1		37046	0.11
chr9_132706317_132706579	0.39	RP11-409K20.6		10633	0.19
chr5_109023784_109023935	0.39	MAN2A1	mannosidase, alpha, class 2A, member 1	1208	0.46
chr1_25348165_25348426	0.39	ENSG00000264371	.	1699	0.42
chr19_7409723_7410061	0.39	CTB-133G6.1		3956	0.19
chr16_29758525_29758676	0.38	C16orf54	chromosome 16 open reading frame 54	1273	0.24
chr1_160642525_160642775	0.38	RP11-404F10.2		152	0.95
chr1_236042427_236042680	0.38	LYST	lysosomal trafficking regulator	4319	0.19
chr1_175158282_175158496	0.38	KIAA0040	KIAA0040	3501	0.33
chr10_974781_975302	0.38	LARP4B	La ribonucleoprotein domain family, member 4B	2523	0.24
chrX_65219330_65219481	0.38	RP6-159A1.3		188	0.95
chr14_90148267_90148437	0.38	ENSG00000200312	.	30503	0.14
chr18_11973646_11973800	0.38	IMPA2	inositol(myo)-1(or 4)-monophosphatase 2	7313	0.17
chr20_30639419_30639649	0.38	HCK	hemopoietic cell kinase	457	0.65
chr9_130541716_130542127	0.38	SH2D3C	SH2 domain containing 3C	901	0.36
chr17_72460689_72460840	0.38	CD300A	CD300a molecule	1791	0.28
chr10_28555808_28555987	0.38	MPP7	membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)	13174	0.24
chr15_91471825_91472109	0.38	UNC45A	unc-45 homolog A (C. elegans)	1443	0.2
chr11_67170134_67170292	0.37	PPP1CA	protein phosphatase 1, catalytic subunit, alpha isozyme	811	0.3
chr3_107845906_107846057	0.37	CD47	CD47 molecule	36109	0.21
chr13_41536432_41536583	0.37	ELF1	E74-like factor 1 (ets domain transcription factor)	19911	0.17
chr9_36127260_36127411	0.37	GLIPR2	GLI pathogenesis-related 2	9397	0.2
chr11_67803091_67803252	0.37	ENSG00000266737	.	1807	0.2
chr10_6192567_6192718	0.37	ENSG00000201581	.	1056	0.37
chrX_118816754_118816969	0.37	SEPT6	septin 6	9931	0.17
chr16_68035280_68035548	0.37	DPEP2	dipeptidase 2	925	0.34
chr5_75703058_75703479	0.37	IQGAP2	IQ motif containing GTPase activating protein 2	3019	0.37
chr16_68039205_68039423	0.37	DPEP2	dipeptidase 2	4825	0.09
chr11_47787493_47787651	0.37	FNBP4	formin binding protein 4	1281	0.36
chr17_61742210_61742415	0.37	LIMD2	LIM domain containing 2	34210	0.11
chr1_200324007_200324168	0.37	ZNF281	zinc finger protein 281	55033	0.16
chr19_45118569_45118720	0.37	IGSF23	immunoglobulin superfamily, member 23	1404	0.36
chr12_32044487_32044661	0.36	ENSG00000252584	.	24067	0.19
chr16_84118584_84118936	0.36	MBTPS1	membrane-bound transcription factor peptidase, site 1	31640	0.1
chr15_55548229_55548380	0.36	RAB27A	RAB27A, member RAS oncogene family	7071	0.22
chr9_92083779_92083991	0.36	SEMA4D	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D	10920	0.23
chr2_152946053_152946204	0.36	AC079790.2		8714	0.23
chr13_29245903_29246054	0.36	POMP	proteasome maturation protein	12737	0.22
chr10_65033826_65034075	0.36	JMJD1C	jumonji domain containing 1C	4968	0.31
chr10_22899051_22899369	0.35	PIP4K2A	phosphatidylinositol-5-phosphate 4-kinase, type II, alpha	18568	0.27
chr13_46748526_46748734	0.35	ENSG00000240767	.	4747	0.18
chr8_131013976_131014127	0.35	ENSG00000253043	.	2796	0.24
chr1_94847923_94848210	0.35	ABCD3	ATP-binding cassette, sub-family D (ALD), member 3	35867	0.21
chr2_198170819_198171012	0.35	ANKRD44-IT1	ANKRD44 intronic transcript 1 (non-protein coding)	3672	0.19
chr5_171610725_171610974	0.35	STK10	serine/threonine kinase 10	4541	0.22
chr11_78002110_78002261	0.35	RP11-452H21.1		33619	0.15
chr1_236119060_236119211	0.34	ENSG00000206803	.	40420	0.15
chr11_118086321_118086769	0.34	AMICA1	adhesion molecule, interacts with CXADR antigen 1	939	0.49
chr2_118862867_118863154	0.34	INSIG2	insulin induced gene 2	16960	0.23
chr7_72705805_72706094	0.34	GTF2IRD2P1	GTF2I repeat domain containing 2 pseudogene 1	11806	0.13
chrX_13106601_13106839	0.34	FAM9C	family with sequence similarity 9, member C	43919	0.18
chr11_65129743_65129938	0.34	RP11-867O8.5		5069	0.12
chr8_131026287_131026438	0.34	FAM49B	family with sequence similarity 49, member B	2289	0.26
chr19_8637419_8637590	0.34	MYO1F	myosin IF	4818	0.13
chr8_37740940_37741137	0.34	RAB11FIP1	RAB11 family interacting protein 1 (class I)	5403	0.16
chr10_94519655_94519819	0.34	ENSG00000201412	.	49372	0.14
chr15_45016174_45016712	0.34	TRIM69	tripartite motif containing 69	4743	0.17
chr14_31332302_31332509	0.34	COCH	cochlin	11344	0.19
chr12_116996199_116996350	0.34	MAP1LC3B2	microtubule-associated protein 1 light chain 3 beta 2	912	0.71
chr19_39823552_39823765	0.34	GMFG	glia maturation factor, gamma	2987	0.12
chr1_38318566_38318717	0.34	MTF1	metal-regulatory transcription factor 1	6651	0.1
chr7_75057844_75058027	0.34	POM121C	POM121 transmembrane nucleoporin C	12044	0.11
chr1_36951055_36951342	0.34	CSF3R	colony stimulating factor 3 receptor (granulocyte)	2319	0.26
chr4_174334008_174334159	0.34	SCRG1	stimulator of chondrogenesis 1	13396	0.16
chr1_111422442_111422718	0.34	CD53	CD53 molecule	6804	0.2
chrX_128912114_128912265	0.34	SASH3	SAM and SH3 domain containing 3	1771	0.37
chr11_126150070_126150221	0.34	ENSG00000238855	.	1407	0.23
chr19_39825172_39825326	0.33	GMFG	glia maturation factor, gamma	1396	0.23
chr8_23083252_23083625	0.33	ENSG00000246582	.	704	0.4
chr15_70773811_70774097	0.33	UACA	uveal autoantigen with coiled-coil domains and ankyrin repeats	220666	0.02
chrX_39003232_39003473	0.33	ENSG00000207122	.	62814	0.16
chr9_237130_237418	0.33	C9orf66	chromosome 9 open reading frame 66	21381	0.16
chr15_68072714_68072930	0.33	SKOR1	SKI family transcriptional corepressor 1	39220	0.19
chr12_49429606_49429757	0.33	KMT2D	lysine (K)-specific methyltransferase 2D	11274	0.08
chr17_76757237_76757578	0.33	CYTH1	cytohesin 1	20947	0.17
chr4_84039114_84039366	0.33	PLAC8	placenta-specific 8	3285	0.3
chr5_138849723_138849988	0.33	AC138517.1	Uncharacterized protein	2253	0.22
chr12_46610230_46610399	0.33	SLC38A1	solute carrier family 38, member 1	51170	0.18
chrX_109131195_109131433	0.33	TMEM164	transmembrane protein 164	114549	0.06
chr8_96066426_96066577	0.33	ENSG00000200525	.	941	0.51
chr1_200996525_200996676	0.33	KIF21B	kinesin family member 21B	3772	0.22
chr5_156711613_156711855	0.33	CYFIP2	cytoplasmic FMR1 interacting protein 2	638	0.67
chr16_87327_87687	0.32	WASIR2	WASH and IL9R antisense RNA 2	14597	0.09
chr17_76133393_76133675	0.32	TMC6	transmembrane channel-like 6	5046	0.12
chr6_2943685_2943993	0.32	SERPINB6	serpin peptidase inhibitor, clade B (ovalbumin), member 6	17722	0.15
chr1_154465340_154465491	0.32	SHE	Src homology 2 domain containing E	3773	0.15
chr8_41901886_41902091	0.32	ENSG00000238966	.	895	0.61
chr3_75297773_75298078	0.32	ENSG00000266780	.	34298	0.19
chr8_96066927_96067078	0.32	ENSG00000200525	.	440	0.79
chr3_141408536_141408833	0.32	RNF7	ring finger protein 7	48362	0.15
chr12_54687660_54687811	0.32	NFE2	nuclear factor, erythroid 2	1807	0.16
chr2_74176334_74176485	0.32	ENSG00000201876	.	18924	0.14
chr12_122226888_122227039	0.32	RHOF	ras homolog family member F (in filopodia)	4303	0.19
chr3_141218689_141219075	0.32	RASA2	RAS p21 protein activator 2	12991	0.21
chr7_50320921_50321337	0.32	IKZF1	IKAROS family zinc finger 1 (Ikaros)	23195	0.25
chrX_134517228_134517850	0.32	ZNF449	zinc finger protein 449	38818	0.14
chr2_74267610_74267798	0.32	TET3	tet methylcytosine dioxygenase 3	5746	0.2
chr17_28047032_28047183	0.32	RP11-82O19.1		41014	0.1
chr12_725461_725775	0.32	NINJ2	ninjurin 2	6034	0.15
chr2_171985958_171986116	0.32	ENSG00000238567	.	16803	0.23
chr14_65166200_65166363	0.32	PLEKHG3	pleckstrin homology domain containing, family G (with RhoGef domain) member 3	4539	0.26
chr17_38432077_38432239	0.32	CDC6	cell division cycle 6	11727	0.13
chr12_12633904_12634353	0.31	DUSP16	dual specificity phosphatase 16	39931	0.17
chrX_12971604_12971797	0.31	TMSB4X	thymosin beta 4, X-linked	21527	0.18
chr11_117873127_117873566	0.31	IL10RA	interleukin 10 receptor, alpha	16237	0.17
chr7_105713236_105713439	0.31	SYPL1	synaptophysin-like 1	24971	0.22
chr11_62405884_62406075	0.31	GANAB	glucosidase, alpha; neutral AB	8102	0.06
chr12_95071033_95071226	0.31	TMCC3	transmembrane and coiled-coil domain family 3	26791	0.23
chr15_68352473_68352742	0.31	PIAS1	protein inhibitor of activated STAT, 1	5693	0.3
chr9_95800059_95800489	0.31	SUSD3	sushi domain containing 3	20715	0.16
chr3_112692893_112693044	0.31	CD200R1	CD200 receptor 1	791	0.59
chr1_10009775_10009997	0.31	ENSG00000202415	.	2510	0.16
chr2_144019176_144019327	0.31	RP11-190J23.1		89510	0.09
chr11_85359177_85359361	0.31	TMEM126A	transmembrane protein 126A	204	0.92
chr19_19504964_19505254	0.31	GATAD2A	GATA zinc finger domain containing 2A	8277	0.14
chr10_99168726_99168877	0.31	RRP12	ribosomal RNA processing 12 homolog (S. cerevisiae)	7674	0.1
chr12_65058242_65058402	0.31	RP11-338E21.3		9523	0.14
chr3_18787817_18787968	0.31	ENSG00000228956	.	656	0.84
chr7_38273677_38273831	0.31	STARD3NL	STARD3 N-terminal like	55757	0.17
chr19_16373633_16373875	0.31	CTD-2562J15.6		30632	0.12
chr17_268531_268682	0.31	AC108004.3		4792	0.16
chr6_5831966_5832410	0.31	ENSG00000239472	.	86889	0.1
chr3_47018543_47018729	0.31	CCDC12	coiled-coil domain containing 12	366	0.84
chr9_129128188_129128339	0.31	MVB12B	multivesicular body subunit 12B	10459	0.23
chr19_41841226_41841377	0.30	TGFB1	transforming growth factor, beta 1	6634	0.1
chr5_130403929_130404353	0.30	HINT1	histidine triad nucleotide binding protein 1	94179	0.09
chr14_91608866_91609056	0.30	C14orf159	chromosome 14 open reading frame 159	5161	0.17
chr5_57789550_57789701	0.30	GAPT	GRB2-binding adaptor protein, transmembrane	442	0.84
chr17_8827866_8828125	0.30	PIK3R5	phosphoinositide-3-kinase, regulatory subunit 5	12161	0.23
chr14_58894740_58894891	0.30	KIAA0586	KIAA0586	107	0.84
chr14_35754152_35754303	0.30	PSMA6	proteasome (prosome, macropain) subunit, alpha type, 6	6388	0.23
chr19_40450383_40450562	0.30	FCGBP	Fc fragment of IgG binding protein	9939	0.16
chr14_21250924_21251123	0.30	RP11-219E7.1		1024	0.34
chr22_43361982_43362133	0.30	PACSIN2	protein kinase C and casein kinase substrate in neurons 2	6152	0.24
chr4_6930540_6930691	0.30	TBC1D14	TBC1 domain family, member 14	18640	0.15
chr12_82336825_82337040	0.30	PPFIA2	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2	183600	0.03
chr16_88861668_88862015	0.30	CDT1	chromatin licensing and DNA replication factor 1	7780	0.09
chr19_15573327_15573521	0.30	RASAL3	RAS protein activator like 3	1958	0.22
chr6_108574805_108575074	0.30	ENSG00000212525	.	1334	0.36
chr17_39465993_39466216	0.30	KRTAP16-1	keratin associated protein 16-1	599	0.52
chr12_116509655_116509806	0.30	ENSG00000200665	.	10645	0.24
chr14_22565547_22565859	0.30	ENSG00000238634	.	45184	0.18
chr11_122560039_122560190	0.30	UBASH3B	ubiquitin associated and SH3 domain containing B	33731	0.17
chr10_12285389_12285540	0.30	RP11-186N15.3		2693	0.21
chr2_206411815_206412034	0.30	NRP2	neuropilin 2	135300	0.05
chr1_204483596_204483747	0.30	MDM4	Mdm4 p53 binding protein homolog (mouse)	1840	0.33
chr2_84469251_84469402	0.30	SUCLG1	succinate-CoA ligase, alpha subunit	217278	0.02
chr16_11404696_11404930	0.30	ENSG00000199668	.	4111	0.09
chr14_105530935_105531132	0.30	GPR132	G protein-coupled receptor 132	734	0.67
chr19_14499483_14499814	0.30	CD97	CD97 molecule	7392	0.14
chr3_46021204_46021377	0.30	FYCO1	FYVE and coiled-coil domain containing 1	5197	0.2
chr11_121339389_121339540	0.30	RP11-730K11.1		15742	0.23
chr16_88758585_88759067	0.30	RP5-1142A6.5		4083	0.08
chr2_75066333_75066484	0.29	HK2	hexokinase 2	4111	0.3
chr21_43608926_43609283	0.29	ABCG1	ATP-binding cassette, sub-family G (WHITE), member 1	10695	0.19
chr19_1077652_1078026	0.29	HMHA1	histocompatibility (minor) HA-1	397	0.71
chr7_105089303_105089490	0.29	PUS7	pseudouridylate synthase 7 homolog (S. cerevisiae)	59186	0.11
chr3_169723415_169723566	0.29	SEC62-AS1	SEC62 antisense RNA 1	19987	0.13
chr1_231666051_231666202	0.29	TSNAX	translin-associated factor X	1725	0.31
chr3_42570391_42570707	0.29	VIPR1-AS1	VIPR1 antisense RNA 1	3005	0.21
chr20_43609558_43609709	0.29	STK4	serine/threonine kinase 4	14466	0.14
chr11_121304779_121304930	0.29	SORL1	sortilin-related receptor, L(DLR class) A repeats containing	18058	0.22
chr11_47970303_47970454	0.29	PTPRJ	protein tyrosine phosphatase, receptor type, J	31735	0.17
chr7_13144079_13144230	0.29	ENSG00000222974	.	227845	0.02
chr13_41226625_41226792	0.29	FOXO1	forkhead box O1	14026	0.23
chr20_52472220_52472443	0.29	AC005220.3		84368	0.1
chr12_133347477_133347628	0.29	ANKLE2	ankyrin repeat and LEM domain containing 2	9078	0.15
chrX_154029557_154029796	0.29	MPP1	membrane protein, palmitoylated 1, 55kDa	3996	0.15
chr1_51895831_51895993	0.29	EPS15	epidermal growth factor receptor pathway substrate 15	6922	0.18
chr3_151822090_151822328	0.29	MBNL1	muscleblind-like splicing regulator 1	163620	0.03

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of PITX2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.6	GO:0006991	response to sterol depletion(GO:0006991)
0.1	0.3	GO:0001672	regulation of chromatin assembly or disassembly(GO:0001672)
0.1	0.2	GO:0010956	negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137)
0.1	0.2	GO:0032959	inositol trisphosphate biosynthetic process(GO:0032959)
0.1	0.1	GO:0032957	inositol trisphosphate metabolic process(GO:0032957)
0.1	0.3	GO:0002726	positive regulation of T cell cytokine production(GO:0002726)
0.1	0.2	GO:0022007	neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007)
0.1	0.2	GO:0010447	response to acidic pH(GO:0010447)
0.1	0.2	GO:0043951	negative regulation of cAMP-mediated signaling(GO:0043951)
0.1	0.2	GO:0030011	maintenance of cell polarity(GO:0030011)
0.1	0.5	GO:0015671	oxygen transport(GO:0015671)
0.1	0.1	GO:0070340	detection of bacterial lipoprotein(GO:0042494) detection of bacterial lipopeptide(GO:0070340)
0.1	0.2	GO:0003056	regulation of vascular smooth muscle contraction(GO:0003056)
0.1	0.2	GO:1904358	positive regulation of telomere maintenance via telomerase(GO:0032212) positive regulation of telomere maintenance via telomere lengthening(GO:1904358)
0.1	0.2	GO:0048478	replication fork protection(GO:0048478)
0.1	0.2	GO:0032661	interleukin-18 production(GO:0032621) regulation of interleukin-18 production(GO:0032661)
0.1	0.2	GO:0032025	response to cobalt ion(GO:0032025)
0.1	0.4	GO:0050687	negative regulation of defense response to virus(GO:0050687)
0.1	0.3	GO:0046668	regulation of retinal cell programmed cell death(GO:0046668)
0.1	0.2	GO:0030948	negative regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030948)
0.1	0.3	GO:0046835	carbohydrate phosphorylation(GO:0046835)
0.1	0.2	GO:0032509	endosome transport via multivesicular body sorting pathway(GO:0032509)
0.0	0.1	GO:0018076	N-terminal peptidyl-lysine acetylation(GO:0018076)
0.0	0.1	GO:0006003	fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0	0.1	GO:0032506	cytokinetic process(GO:0032506)
0.0	0.3	GO:0043353	enucleate erythrocyte differentiation(GO:0043353)
0.0	0.4	GO:0006491	N-glycan processing(GO:0006491)
0.0	0.1	GO:0002323	natural killer cell activation involved in immune response(GO:0002323) natural killer cell degranulation(GO:0043320)
0.0	0.1	GO:0045722	positive regulation of gluconeogenesis(GO:0045722)
0.0	0.3	GO:0033169	histone H3-K9 demethylation(GO:0033169)
0.0	0.3	GO:0071157	negative regulation of cell cycle arrest(GO:0071157)
0.0	0.2	GO:0042159	lipoprotein catabolic process(GO:0042159)
0.0	0.1	GO:0008588	release of cytoplasmic sequestered NF-kappaB(GO:0008588)
0.0	0.1	GO:0015917	aminophospholipid transport(GO:0015917)
0.0	0.3	GO:0006614	SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.0	0.3	GO:0033235	positive regulation of protein sumoylation(GO:0033235)
0.0	0.2	GO:0002507	tolerance induction(GO:0002507)
0.0	0.1	GO:0040016	embryonic cleavage(GO:0040016)
0.0	0.1	GO:0007500	mesodermal cell fate determination(GO:0007500)
0.0	0.1	GO:0030223	neutrophil differentiation(GO:0030223)
0.0	0.1	GO:0097576	vacuole fusion(GO:0097576)
0.0	0.1	GO:0006167	AMP biosynthetic process(GO:0006167)
0.0	0.4	GO:0006744	ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744)
0.0	0.1	GO:0055098	response to low-density lipoprotein particle(GO:0055098)
0.0	0.1	GO:0035405	histone-threonine phosphorylation(GO:0035405)
0.0	0.1	GO:0045356	positive regulation of interferon-alpha biosynthetic process(GO:0045356)
0.0	0.1	GO:0019532	oxalate transport(GO:0019532)
0.0	0.2	GO:0050857	positive regulation of antigen receptor-mediated signaling pathway(GO:0050857)
0.0	0.2	GO:0045084	positive regulation of interleukin-12 biosynthetic process(GO:0045084)
0.0	0.3	GO:0045749	obsolete negative regulation of S phase of mitotic cell cycle(GO:0045749)
0.0	0.2	GO:0045003	DNA recombinase assembly(GO:0000730) double-strand break repair via synthesis-dependent strand annealing(GO:0045003)
0.0	0.0	GO:0048087	positive regulation of developmental pigmentation(GO:0048087)
0.0	0.2	GO:0006613	cotranslational protein targeting to membrane(GO:0006613)
0.0	0.1	GO:0045634	regulation of melanocyte differentiation(GO:0045634) regulation of pigment cell differentiation(GO:0050932)
0.0	0.1	GO:0002125	maternal aggressive behavior(GO:0002125)
0.0	0.1	GO:0030538	embryonic genitalia morphogenesis(GO:0030538)
0.0	0.1	GO:0019441	tryptophan catabolic process to kynurenine(GO:0019441)
0.0	0.1	GO:0042119	neutrophil activation(GO:0042119)
0.0	0.1	GO:0071360	cellular response to exogenous dsRNA(GO:0071360)
0.0	0.1	GO:0045589	regulation of regulatory T cell differentiation(GO:0045589)
0.0	0.1	GO:0015015	heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0	0.1	GO:0008215	spermine metabolic process(GO:0008215)
0.0	0.1	GO:0046618	drug export(GO:0046618)
0.0	0.1	GO:0045292	mRNA cis splicing, via spliceosome(GO:0045292)
0.0	0.1	GO:0070682	proteasome regulatory particle assembly(GO:0070682)
0.0	0.1	GO:0035066	positive regulation of histone acetylation(GO:0035066) positive regulation of protein acetylation(GO:1901985) positive regulation of peptidyl-lysine acetylation(GO:2000758)
0.0	0.2	GO:0070935	3'-UTR-mediated mRNA stabilization(GO:0070935)
0.0	0.1	GO:0002475	antigen processing and presentation via MHC class Ib(GO:0002475)
0.0	0.3	GO:0060644	mammary gland epithelial cell differentiation(GO:0060644)
0.0	0.4	GO:0044409	entry into host cell(GO:0030260) entry into host(GO:0044409) entry into cell of other organism involved in symbiotic interaction(GO:0051806) entry into other organism involved in symbiotic interaction(GO:0051828)
0.0	0.2	GO:0030889	negative regulation of B cell proliferation(GO:0030889)
0.0	0.1	GO:0010508	positive regulation of autophagy(GO:0010508)
0.0	0.1	GO:0033080	immature T cell proliferation in thymus(GO:0033080)
0.0	0.1	GO:0006419	alanyl-tRNA aminoacylation(GO:0006419)
0.0	0.1	GO:0042726	flavin-containing compound metabolic process(GO:0042726)
0.0	0.1	GO:0002674	negative regulation of acute inflammatory response(GO:0002674)
0.0	0.1	GO:0070837	dehydroascorbic acid transport(GO:0070837)
0.0	0.1	GO:0001661	conditioned taste aversion(GO:0001661)
0.0	0.2	GO:0042347	negative regulation of NF-kappaB import into nucleus(GO:0042347)
0.0	0.1	GO:2000644	regulation of low-density lipoprotein particle receptor catabolic process(GO:0032803) regulation of receptor catabolic process(GO:2000644)
0.0	0.0	GO:0034139	regulation of toll-like receptor 3 signaling pathway(GO:0034139)
0.0	0.2	GO:0071391	cellular response to estrogen stimulus(GO:0071391)
0.0	0.2	GO:0016045	detection of bacterium(GO:0016045)
0.0	0.1	GO:0001821	histamine secretion(GO:0001821)
0.0	0.1	GO:0002138	retinoic acid biosynthetic process(GO:0002138) diterpenoid biosynthetic process(GO:0016102)
0.0	0.5	GO:0045730	respiratory burst(GO:0045730)
0.0	0.1	GO:0006102	isocitrate metabolic process(GO:0006102)
0.0	0.1	GO:0034755	iron ion transmembrane transport(GO:0034755)
0.0	0.1	GO:0006451	selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.0	0.0	GO:0042402	amine catabolic process(GO:0009310) cellular biogenic amine catabolic process(GO:0042402)
0.0	0.3	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.0	0.1	GO:0002495	antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.0	0.1	GO:0031062	positive regulation of histone methylation(GO:0031062)
0.0	0.1	GO:0030186	melatonin metabolic process(GO:0030186) melatonin biosynthetic process(GO:0030187)
0.0	0.0	GO:0032823	regulation of natural killer cell differentiation(GO:0032823) positive regulation of natural killer cell differentiation(GO:0032825)
0.0	0.2	GO:0030206	chondroitin sulfate biosynthetic process(GO:0030206)
0.0	0.1	GO:0002523	leukocyte migration involved in inflammatory response(GO:0002523)
0.0	0.1	GO:0007028	cytoplasm organization(GO:0007028)
0.0	0.1	GO:0051016	barbed-end actin filament capping(GO:0051016)
0.0	0.1	GO:0071481	cellular response to X-ray(GO:0071481)
0.0	0.1	GO:0032455	nerve growth factor processing(GO:0032455)
0.0	0.1	GO:0043312	neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312)
0.0	0.1	GO:0033314	mitotic DNA replication checkpoint(GO:0033314)
0.0	0.1	GO:0046827	positive regulation of protein export from nucleus(GO:0046827)
0.0	0.1	GO:0050765	negative regulation of phagocytosis(GO:0050765)
0.0	0.3	GO:0051568	histone H3-K4 methylation(GO:0051568)
0.0	0.2	GO:0050856	regulation of T cell receptor signaling pathway(GO:0050856)
0.0	0.0	GO:0051088	PMA-inducible membrane protein ectodomain proteolysis(GO:0051088)
0.0	0.1	GO:0030174	regulation of DNA-dependent DNA replication initiation(GO:0030174)
0.0	0.2	GO:0031269	pseudopodium assembly(GO:0031269) regulation of pseudopodium assembly(GO:0031272) positive regulation of pseudopodium assembly(GO:0031274)
0.0	0.1	GO:0042989	sequestering of actin monomers(GO:0042989)
0.0	0.0	GO:0018125	peptidyl-cysteine methylation(GO:0018125)
0.0	0.1	GO:0045793	positive regulation of cell size(GO:0045793)
0.0	0.3	GO:0050732	negative regulation of peptidyl-tyrosine phosphorylation(GO:0050732)
0.0	0.2	GO:1902603	carnitine shuttle(GO:0006853) carnitine transmembrane transport(GO:1902603)
0.0	0.1	GO:1902624	positive regulation of neutrophil chemotaxis(GO:0090023) positive regulation of neutrophil migration(GO:1902624)
0.0	0.1	GO:1901661	quinone metabolic process(GO:1901661)
0.0	0.2	GO:0008653	lipopolysaccharide metabolic process(GO:0008653)
0.0	0.1	GO:0046931	pore complex assembly(GO:0046931)
0.0	0.0	GO:0046015	carbon catabolite regulation of transcription(GO:0045990) regulation of transcription by glucose(GO:0046015)
0.0	0.1	GO:0072526	pyridine-containing compound catabolic process(GO:0072526)
0.0	0.1	GO:0018106	peptidyl-histidine phosphorylation(GO:0018106)
0.0	0.1	GO:0002032	desensitization of G-protein coupled receptor protein signaling pathway by arrestin(GO:0002032)
0.0	0.1	GO:0022614	membrane to membrane docking(GO:0022614)
0.0	0.3	GO:0048024	regulation of mRNA splicing, via spliceosome(GO:0048024)
0.0	0.1	GO:0051531	NFAT protein import into nucleus(GO:0051531) regulation of NFAT protein import into nucleus(GO:0051532)
0.0	0.0	GO:0002691	regulation of cellular extravasation(GO:0002691)
0.0	0.1	GO:0006556	S-adenosylmethionine biosynthetic process(GO:0006556)
0.0	0.1	GO:0002327	immature B cell differentiation(GO:0002327) pre-B cell differentiation(GO:0002329)
0.0	0.3	GO:0032008	positive regulation of TOR signaling(GO:0032008)
0.0	0.1	GO:0070934	CRD-mediated mRNA stabilization(GO:0070934)
0.0	0.1	GO:0006565	L-serine catabolic process(GO:0006565)
0.0	0.1	GO:0046485	ether lipid metabolic process(GO:0046485)
0.0	0.1	GO:0016246	RNA interference(GO:0016246)
0.0	0.2	GO:0031498	nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.0	0.1	GO:0018026	peptidyl-lysine monomethylation(GO:0018026)
0.0	0.1	GO:0032790	ribosome disassembly(GO:0032790)
0.0	0.0	GO:0019060	intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) regulation by virus of viral protein levels in host cell(GO:0046719) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708)
0.0	0.1	GO:0043248	proteasome assembly(GO:0043248)
0.0	0.3	GO:0007128	meiotic prophase I(GO:0007128)
0.0	0.0	GO:0061154	endothelial tube morphogenesis(GO:0061154)
0.0	0.1	GO:0045601	regulation of endothelial cell differentiation(GO:0045601)
0.0	0.1	GO:0000183	chromatin silencing at rDNA(GO:0000183)
0.0	0.0	GO:0014012	peripheral nervous system axon regeneration(GO:0014012)
0.0	0.0	GO:0044254	multicellular organismal protein catabolic process(GO:0044254) protein digestion(GO:0044256) multicellular organismal macromolecule catabolic process(GO:0044266) multicellular organismal protein metabolic process(GO:0044268)
0.0	0.1	GO:0030502	negative regulation of bone mineralization(GO:0030502)
0.0	0.0	GO:0034587	piRNA metabolic process(GO:0034587)
0.0	0.1	GO:2000143	negative regulation of transcription initiation from RNA polymerase II promoter(GO:0060633) negative regulation of DNA-templated transcription, initiation(GO:2000143)
0.0	0.1	GO:0032525	somite rostral/caudal axis specification(GO:0032525)
0.0	0.1	GO:0006474	N-terminal protein amino acid acetylation(GO:0006474)
0.0	0.0	GO:0001878	response to yeast(GO:0001878)
0.0	0.1	GO:0072531	pyrimidine-containing compound transmembrane transport(GO:0072531)
0.0	0.0	GO:0045343	MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343)
0.0	0.1	GO:0060235	lens induction in camera-type eye(GO:0060235)
0.0	0.1	GO:0043267	negative regulation of potassium ion transport(GO:0043267)
0.0	0.1	GO:0042769	DNA damage response, detection of DNA damage(GO:0042769)
0.0	0.1	GO:0051387	negative regulation of neurotrophin TRK receptor signaling pathway(GO:0051387)
0.0	0.1	GO:0006657	CDP-choline pathway(GO:0006657)
0.0	0.1	GO:0001562	response to protozoan(GO:0001562) defense response to protozoan(GO:0042832)
0.0	0.1	GO:0051085	chaperone mediated protein folding requiring cofactor(GO:0051085)
0.0	0.0	GO:0050691	regulation of defense response to virus by host(GO:0050691)
0.0	0.1	GO:0019885	antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous antigen(GO:0019883) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.0	0.2	GO:0000050	urea cycle(GO:0000050)
0.0	0.0	GO:0000212	meiotic spindle organization(GO:0000212)
0.0	0.1	GO:0030091	protein repair(GO:0030091)
0.0	0.1	GO:0034374	low-density lipoprotein particle remodeling(GO:0034374)
0.0	0.0	GO:0031125	rRNA 3'-end processing(GO:0031125)
0.0	0.0	GO:0034244	negative regulation of DNA-templated transcription, elongation(GO:0032785) negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244)
0.0	0.0	GO:0019987	obsolete negative regulation of anti-apoptosis(GO:0019987)
0.0	0.1	GO:0002862	negative regulation of inflammatory response to antigenic stimulus(GO:0002862)
0.0	0.0	GO:0051974	negative regulation of telomerase activity(GO:0051974)
0.0	0.1	GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:0006978)
0.0	0.0	GO:0002923	regulation of humoral immune response mediated by circulating immunoglobulin(GO:0002923) positive regulation of humoral immune response mediated by circulating immunoglobulin(GO:0002925)
0.0	0.3	GO:0046834	lipid phosphorylation(GO:0046834)
0.0	0.1	GO:0051290	protein heterotetramerization(GO:0051290)
0.0	0.1	GO:0018345	protein palmitoylation(GO:0018345)
0.0	0.0	GO:0040009	regulation of growth rate(GO:0040009)
0.0	0.1	GO:0042424	phenol-containing compound catabolic process(GO:0019336) catechol-containing compound catabolic process(GO:0019614) catecholamine catabolic process(GO:0042424)
0.0	0.1	GO:0033522	histone H2A ubiquitination(GO:0033522)
0.0	0.1	GO:0060009	Sertoli cell development(GO:0060009)
0.0	0.4	GO:0050690	regulation of defense response to virus by virus(GO:0050690)
0.0	0.1	GO:0072600	protein targeting to Golgi(GO:0000042) establishment of protein localization to Golgi(GO:0072600)
0.0	0.1	GO:0090080	positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway(GO:0090080)
0.0	0.1	GO:0000394	RNA splicing, via endonucleolytic cleavage and ligation(GO:0000394) tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.0	0.1	GO:0035455	response to interferon-alpha(GO:0035455)
0.0	0.1	GO:0006346	methylation-dependent chromatin silencing(GO:0006346)
0.0	0.0	GO:0006684	sphingomyelin metabolic process(GO:0006684)
0.0	0.0	GO:0052251	induction by organism of defense response of other organism involved in symbiotic interaction(GO:0052251)
0.0	0.1	GO:0090196	chemokine secretion(GO:0090195) regulation of chemokine secretion(GO:0090196) positive regulation of chemokine secretion(GO:0090197)
0.0	0.2	GO:0006662	glycerol ether metabolic process(GO:0006662) ether metabolic process(GO:0018904)
0.0	0.1	GO:0007440	foregut morphogenesis(GO:0007440) embryonic foregut morphogenesis(GO:0048617)
0.0	0.0	GO:0045351	type I interferon biosynthetic process(GO:0045351)
0.0	0.1	GO:0045061	thymic T cell selection(GO:0045061)
0.0	0.1	GO:0031580	membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.0	0.0	GO:0010310	regulation of hydrogen peroxide metabolic process(GO:0010310)
0.0	0.0	GO:0045071	negative regulation of viral genome replication(GO:0045071)
0.0	0.0	GO:0043301	negative regulation of myeloid leukocyte mediated immunity(GO:0002887) negative regulation of leukocyte degranulation(GO:0043301)
0.0	0.1	GO:0034625	fatty acid elongation, monounsaturated fatty acid(GO:0034625)
0.0	0.1	GO:0006264	mitochondrial DNA replication(GO:0006264)
0.0	0.0	GO:0051547	regulation of keratinocyte migration(GO:0051547) positive regulation of keratinocyte migration(GO:0051549)
0.0	0.0	GO:0048548	regulation of pinocytosis(GO:0048548)
0.0	0.0	GO:2001021	negative regulation of response to DNA damage stimulus(GO:2001021)
0.0	0.0	GO:0010452	histone H3-K36 methylation(GO:0010452)
0.0	0.1	GO:2000193	positive regulation of fatty acid transport(GO:2000193)
0.0	0.4	GO:0006692	prostanoid metabolic process(GO:0006692)
0.0	0.0	GO:0042819	pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 metabolic process(GO:0042816) vitamin B6 biosynthetic process(GO:0042819)
0.0	0.1	GO:0051319	mitotic G2 phase(GO:0000085) G2 phase(GO:0051319)
0.0	0.0	GO:0070076	histone lysine demethylation(GO:0070076)
0.0	0.0	GO:0033033	negative regulation of myeloid cell apoptotic process(GO:0033033)
0.0	0.0	GO:0019511	peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) 4-hydroxyproline metabolic process(GO:0019471) peptidyl-proline hydroxylation(GO:0019511)
0.0	0.0	GO:0033147	negative regulation of intracellular estrogen receptor signaling pathway(GO:0033147)
0.0	0.5	GO:0015682	ferric iron transport(GO:0015682) transferrin transport(GO:0033572) trivalent inorganic cation transport(GO:0072512)
0.0	0.3	GO:0001522	pseudouridine synthesis(GO:0001522)
0.0	0.1	GO:0060123	regulation of growth hormone secretion(GO:0060123)
0.0	0.0	GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
0.0	0.0	GO:0045348	positive regulation of MHC class II biosynthetic process(GO:0045348)
0.0	0.1	GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress(GO:0008631) cell death in response to oxidative stress(GO:0036473)
0.0	0.0	GO:0015742	alpha-ketoglutarate transport(GO:0015742)
0.0	0.0	GO:0045767	obsolete regulation of anti-apoptosis(GO:0045767)
0.0	0.0	GO:0042271	susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.0	0.0	GO:0006448	regulation of translational elongation(GO:0006448)
0.0	0.2	GO:0016578	histone deubiquitination(GO:0016578)
0.0	0.0	GO:0071569	protein ufmylation(GO:0071569)
0.0	0.1	GO:0031116	positive regulation of microtubule polymerization(GO:0031116)
0.0	0.0	GO:0001961	positive regulation of cytokine-mediated signaling pathway(GO:0001961)
0.0	0.0	GO:0042670	retinal cone cell differentiation(GO:0042670) retinal cone cell development(GO:0046549)
0.0	0.0	GO:0046477	glycosylceramide catabolic process(GO:0046477)
0.0	0.0	GO:0031664	regulation of lipopolysaccharide-mediated signaling pathway(GO:0031664)
0.0	0.1	GO:0006686	sphingomyelin biosynthetic process(GO:0006686)
0.0	0.1	GO:0007256	activation of JNKK activity(GO:0007256)
0.0	0.3	GO:0070979	protein K11-linked ubiquitination(GO:0070979)
0.0	0.0	GO:0044380	protein localization to cytoskeleton(GO:0044380) protein localization to microtubule cytoskeleton(GO:0072698)
0.0	0.3	GO:1901185	negative regulation of epidermal growth factor receptor signaling pathway(GO:0042059) negative regulation of ERBB signaling pathway(GO:1901185)
0.0	0.0	GO:0051386	regulation of neurotrophin TRK receptor signaling pathway(GO:0051386)
0.0	0.1	GO:0051382	kinetochore assembly(GO:0051382)
0.0	0.0	GO:0045988	negative regulation of striated muscle contraction(GO:0045988)
0.0	0.1	GO:0034314	Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.0	0.0	GO:0060872	semicircular canal development(GO:0060872)
0.0	0.1	GO:0006572	tyrosine catabolic process(GO:0006572)
0.0	0.0	GO:0048070	regulation of developmental pigmentation(GO:0048070)
0.0	0.1	GO:0006376	mRNA splice site selection(GO:0006376)
0.0	0.0	GO:0045086	positive regulation of interleukin-2 biosynthetic process(GO:0045086)
0.0	0.1	GO:0022417	protein maturation by protein folding(GO:0022417)
0.0	0.1	GO:0000185	activation of MAPKKK activity(GO:0000185)
0.0	0.1	GO:0033687	osteoblast proliferation(GO:0033687)
0.0	0.0	GO:0016559	peroxisome fission(GO:0016559)
0.0	0.1	GO:0045006	DNA deamination(GO:0045006)
0.0	0.1	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors(GO:0008625) extrinsic apoptotic signaling pathway(GO:0097191)
0.0	0.0	GO:0006772	thiamine metabolic process(GO:0006772) thiamine-containing compound metabolic process(GO:0042723)
0.0	0.0	GO:0060762	regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
0.0	0.0	GO:0007144	female meiosis I(GO:0007144)
0.0	0.1	GO:0008354	germ cell migration(GO:0008354)
0.0	0.1	GO:0006104	succinyl-CoA metabolic process(GO:0006104)
0.0	0.1	GO:0050957	equilibrioception(GO:0050957)
0.0	0.2	GO:0006044	N-acetylglucosamine metabolic process(GO:0006044)
0.0	0.7	GO:0050852	T cell receptor signaling pathway(GO:0050852)
0.0	0.0	GO:0045945	positive regulation of transcription from RNA polymerase III promoter(GO:0045945)
0.0	0.4	GO:0000186	activation of MAPKK activity(GO:0000186)
0.0	0.0	GO:0046958	nonassociative learning(GO:0046958)
0.0	0.0	GO:0016572	histone phosphorylation(GO:0016572)
0.0	0.0	GO:0071688	skeletal muscle myosin thick filament assembly(GO:0030241) myosin filament assembly(GO:0031034) striated muscle myosin thick filament assembly(GO:0071688)
0.0	0.0	GO:0048680	positive regulation of axon regeneration(GO:0048680) positive regulation of neuron projection regeneration(GO:0070572)
0.0	0.0	GO:0042339	keratan sulfate metabolic process(GO:0042339)
0.0	0.1	GO:0046470	phosphatidylcholine metabolic process(GO:0046470)
0.0	0.1	GO:0031017	exocrine pancreas development(GO:0031017)
0.0	0.0	GO:0006855	drug transmembrane transport(GO:0006855)
0.0	0.0	GO:0018343	protein farnesylation(GO:0018343)
0.0	0.1	GO:0032715	negative regulation of interleukin-6 production(GO:0032715)
0.0	0.0	GO:0060157	urinary bladder development(GO:0060157)
0.0	0.0	GO:0051541	elastin metabolic process(GO:0051541)
0.0	0.0	GO:0031646	positive regulation of neurological system process(GO:0031646)
0.0	0.1	GO:0000028	ribosomal small subunit assembly(GO:0000028)
0.0	0.0	GO:0007252	I-kappaB phosphorylation(GO:0007252)
0.0	0.1	GO:2000257	regulation of complement activation(GO:0030449) regulation of protein activation cascade(GO:2000257)
0.0	0.0	GO:0071072	negative regulation of phospholipid biosynthetic process(GO:0071072)
0.0	0.1	GO:0006670	sphingosine metabolic process(GO:0006670)
0.0	0.0	GO:0001866	NK T cell proliferation(GO:0001866)
0.0	0.1	GO:0006568	tryptophan metabolic process(GO:0006568) indolalkylamine metabolic process(GO:0006586)
0.0	0.1	GO:0042116	macrophage activation(GO:0042116)
0.0	0.1	GO:0001662	behavioral fear response(GO:0001662) behavioral defense response(GO:0002209)
0.0	0.0	GO:0006007	glucose catabolic process(GO:0006007)
0.0	0.1	GO:0032782	bile acid secretion(GO:0032782)
0.0	0.1	GO:0006896	Golgi to endosome transport(GO:0006895) Golgi to vacuole transport(GO:0006896)
0.0	0.0	GO:0060686	negative regulation of prostatic bud formation(GO:0060686)
0.0	0.0	GO:0006678	glucosylceramide metabolic process(GO:0006678)
0.0	0.0	GO:0030309	poly-N-acetyllactosamine metabolic process(GO:0030309)
0.0	0.1	GO:0051927	obsolete negative regulation of calcium ion transport via voltage-gated calcium channel activity(GO:0051927)
0.0	0.1	GO:0072583	synaptic vesicle recycling(GO:0036465) synaptic vesicle endocytosis(GO:0048488) clathrin-mediated endocytosis(GO:0072583)
0.0	0.0	GO:0042535	positive regulation of tumor necrosis factor biosynthetic process(GO:0042535)
0.0	0.2	GO:0032088	negative regulation of NF-kappaB transcription factor activity(GO:0032088)
0.0	0.0	GO:0006689	ganglioside catabolic process(GO:0006689)
0.0	0.1	GO:0007158	neuron cell-cell adhesion(GO:0007158)
0.0	0.1	GO:0006301	postreplication repair(GO:0006301)
0.0	0.2	GO:0032480	negative regulation of type I interferon production(GO:0032480)
0.0	0.4	GO:0071377	cellular response to glucagon stimulus(GO:0071377)
0.0	0.0	GO:0009186	deoxyribonucleoside diphosphate metabolic process(GO:0009186) deoxyribonucleoside diphosphate biosynthetic process(GO:0009189)
0.0	0.1	GO:0015886	heme transport(GO:0015886)
0.0	0.1	GO:0030149	sphingolipid catabolic process(GO:0030149)
0.0	0.1	GO:0051918	negative regulation of fibrinolysis(GO:0051918)
0.0	0.0	GO:0048261	negative regulation of receptor-mediated endocytosis(GO:0048261)
0.0	0.0	GO:0030970	retrograde protein transport, ER to cytosol(GO:0030970)
0.0	0.0	GO:0045654	positive regulation of megakaryocyte differentiation(GO:0045654) positive regulation of hematopoietic progenitor cell differentiation(GO:1901534)
0.0	0.1	GO:0045723	positive regulation of fatty acid biosynthetic process(GO:0045723)
0.0	0.1	GO:0071636	positive regulation of transforming growth factor beta production(GO:0071636)
0.0	0.1	GO:0034433	steroid esterification(GO:0034433) sterol esterification(GO:0034434) cholesterol esterification(GO:0034435)
0.0	0.0	GO:0043628	ncRNA 3'-end processing(GO:0043628)
0.0	0.1	GO:0022027	interkinetic nuclear migration(GO:0022027)
0.0	0.1	GO:0018214	peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214)
0.0	0.1	GO:0009129	pyrimidine nucleoside monophosphate metabolic process(GO:0009129)
0.0	0.2	GO:0042776	mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.0	0.0	GO:0034214	protein hexamerization(GO:0034214)
0.0	0.1	GO:0043252	sodium-independent organic anion transport(GO:0043252)
0.0	0.1	GO:0007191	adenylate cyclase-activating dopamine receptor signaling pathway(GO:0007191)
0.0	0.1	GO:0006449	regulation of translational termination(GO:0006449)
0.0	0.0	GO:0008218	bioluminescence(GO:0008218)
0.0	0.0	GO:0060159	regulation of dopamine receptor signaling pathway(GO:0060159)
0.0	0.0	GO:0045007	depurination(GO:0045007)
0.0	0.0	GO:0042640	anagen(GO:0042640)
0.0	0.1	GO:0032770	positive regulation of monooxygenase activity(GO:0032770)
0.0	0.0	GO:0051044	positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.0	0.0	GO:0097205	regulation of glomerular filtration(GO:0003093) glomerular filtration(GO:0003094) renal filtration(GO:0097205) regulation of renal system process(GO:0098801)
0.0	0.0	GO:0002069	columnar/cuboidal epithelial cell maturation(GO:0002069)
0.0	0.1	GO:0007217	tachykinin receptor signaling pathway(GO:0007217)
0.0	0.1	GO:0008655	pyrimidine-containing compound salvage(GO:0008655) pyrimidine nucleoside salvage(GO:0043097)
0.0	0.0	GO:0043985	histone H4-R3 methylation(GO:0043985)
0.0	0.1	GO:0006216	cytidine catabolic process(GO:0006216) cytidine deamination(GO:0009972) cytidine metabolic process(GO:0046087)
0.0	0.1	GO:1990542	mitochondrial transmembrane transport(GO:1990542)
0.0	0.0	GO:0051895	negative regulation of focal adhesion assembly(GO:0051895) negative regulation of cell junction assembly(GO:1901889) negative regulation of adherens junction organization(GO:1903392)
0.0	0.0	GO:0007035	vacuolar acidification(GO:0007035)
0.0	0.2	GO:0006305	DNA alkylation(GO:0006305) DNA methylation(GO:0006306)
0.0	0.5	GO:0006521	regulation of cellular amino acid metabolic process(GO:0006521)
0.0	0.1	GO:0032464	positive regulation of protein homooligomerization(GO:0032464)
0.0	0.1	GO:0007029	endoplasmic reticulum organization(GO:0007029)
0.0	0.0	GO:0001757	somite specification(GO:0001757)
0.0	0.1	GO:0043550	regulation of lipid kinase activity(GO:0043550)
0.0	0.0	GO:0046968	peptide antigen transport(GO:0046968)
0.0	0.2	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage(GO:0008630)
0.0	0.1	GO:0002286	T cell activation involved in immune response(GO:0002286)
0.0	0.4	GO:0070646	protein modification by small protein removal(GO:0070646)
0.0	0.0	GO:0035092	sperm chromatin condensation(GO:0035092)
0.0	0.0	GO:0070672	response to interleukin-15(GO:0070672)
0.0	0.1	GO:0071168	protein localization to chromatin(GO:0071168)
0.0	0.0	GO:1900121	regulation of receptor binding(GO:1900120) negative regulation of receptor binding(GO:1900121)
0.0	0.1	GO:0006554	lysine metabolic process(GO:0006553) lysine catabolic process(GO:0006554)
0.0	0.0	GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway(GO:0007195)
0.0	0.2	GO:0006611	protein export from nucleus(GO:0006611)
0.0	0.1	GO:0018208	peptidyl-proline modification(GO:0018208)
0.0	0.0	GO:0050650	chondroitin sulfate proteoglycan biosynthetic process(GO:0050650)
0.0	0.0	GO:0032515	negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.0	0.1	GO:0006002	fructose 6-phosphate metabolic process(GO:0006002)
0.0	0.8	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043123)
0.0	0.0	GO:0090382	phagolysosome assembly(GO:0001845) phagosome maturation(GO:0090382)
0.0	0.1	GO:0044245	polysaccharide digestion(GO:0044245)
0.0	0.1	GO:0006776	vitamin A metabolic process(GO:0006776)
0.0	0.1	GO:0052803	imidazole-containing compound metabolic process(GO:0052803)
0.0	0.0	GO:0016114	terpenoid biosynthetic process(GO:0016114)
0.0	0.1	GO:0032364	oxygen homeostasis(GO:0032364)
0.0	0.0	GO:0032239	regulation of nucleobase-containing compound transport(GO:0032239) regulation of RNA export from nucleus(GO:0046831)
0.0	0.0	GO:0060437	lung growth(GO:0060437)
0.0	0.0	GO:2000171	negative regulation of dendrite development(GO:2000171)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.5	GO:0001891	phagocytic cup(GO:0001891)
0.0	0.1	GO:0032444	activin responsive factor complex(GO:0032444)
0.0	0.1	GO:0042629	mast cell granule(GO:0042629)
0.0	0.1	GO:0042105	alpha-beta T cell receptor complex(GO:0042105)
0.0	0.2	GO:0031088	platelet dense granule membrane(GO:0031088)
0.0	0.2	GO:0048500	signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.0	0.1	GO:0032009	early phagosome(GO:0032009)
0.0	0.1	GO:0031313	extrinsic component of vacuolar membrane(GO:0000306) extrinsic component of endosome membrane(GO:0031313)
0.0	0.2	GO:0030061	mitochondrial crista(GO:0030061)
0.0	0.0	GO:0042827	platelet dense granule(GO:0042827)
0.0	0.1	GO:0031265	CD95 death-inducing signaling complex(GO:0031265)
0.0	0.4	GO:0034362	low-density lipoprotein particle(GO:0034362)
0.0	0.4	GO:0000421	autophagosome membrane(GO:0000421)
0.0	0.1	GO:0008540	proteasome regulatory particle, base subcomplex(GO:0008540)
0.0	0.1	GO:0000800	lateral element(GO:0000800)
0.0	0.1	GO:0048786	presynaptic active zone(GO:0048786)
0.0	0.1	GO:0014731	spectrin-associated cytoskeleton(GO:0014731)
0.0	0.1	GO:0005947	mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947)
0.0	0.2	GO:0000125	PCAF complex(GO:0000125)
0.0	0.2	GO:0032279	asymmetric synapse(GO:0032279) neuron to neuron synapse(GO:0098984)
0.0	0.1	GO:0071664	catenin-TCF7L2 complex(GO:0071664)
0.0	0.0	GO:0005683	U7 snRNP(GO:0005683)
0.0	0.1	GO:0035189	Rb-E2F complex(GO:0035189)
0.0	0.2	GO:0019773	proteasome core complex, alpha-subunit complex(GO:0019773)
0.0	0.2	GO:0016461	unconventional myosin complex(GO:0016461)
0.0	0.1	GO:0033553	rDNA heterochromatin(GO:0033553)
0.0	0.2	GO:0070822	Sin3 complex(GO:0016580) Sin3-type complex(GO:0070822)
0.0	0.2	GO:0042589	zymogen granule membrane(GO:0042589)
0.0	0.2	GO:0005753	mitochondrial proton-transporting ATP synthase complex(GO:0005753) proton-transporting ATP synthase complex(GO:0045259)
0.0	0.2	GO:0034518	mRNA cap binding complex(GO:0005845) RNA cap binding complex(GO:0034518)
0.0	0.2	GO:0031080	nuclear pore outer ring(GO:0031080)
0.0	0.0	GO:0044462	external encapsulating structure part(GO:0044462)
0.0	0.0	GO:0030688	preribosome, small subunit precursor(GO:0030688)
0.0	0.1	GO:0030870	Mre11 complex(GO:0030870)
0.0	0.1	GO:0070937	CRD-mediated mRNA stability complex(GO:0070937)
0.0	0.0	GO:0031933	telomeric heterochromatin(GO:0031933)
0.0	0.1	GO:0000791	euchromatin(GO:0000791)
0.0	0.2	GO:0030670	phagocytic vesicle membrane(GO:0030670)
0.0	0.1	GO:0000138	Golgi trans cisterna(GO:0000138)
0.0	0.1	GO:0051233	spindle midzone(GO:0051233)
0.0	0.2	GO:0008250	oligosaccharyltransferase complex(GO:0008250)
0.0	0.1	GO:0001931	uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0	0.0	GO:0031618	nuclear pericentric heterochromatin(GO:0031618)
0.0	0.1	GO:0070820	tertiary granule(GO:0070820)
0.0	0.1	GO:0033256	I-kappaB/NF-kappaB complex(GO:0033256)
0.0	0.1	GO:0005751	mitochondrial respiratory chain complex IV(GO:0005751) respiratory chain complex IV(GO:0045277)
0.0	0.2	GO:0042101	T cell receptor complex(GO:0042101)
0.0	0.2	GO:0008180	COP9 signalosome(GO:0008180)
0.0	0.2	GO:0005839	proteasome core complex(GO:0005839)
0.0	0.1	GO:0071204	histone pre-mRNA 3'end processing complex(GO:0071204)
0.0	0.1	GO:0005577	fibrinogen complex(GO:0005577)
0.0	0.1	GO:0031428	box C/D snoRNP complex(GO:0031428)
0.0	0.1	GO:0070022	transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0	0.1	GO:0070688	MLL5-L complex(GO:0070688)
0.0	0.0	GO:0030062	mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.0	0.2	GO:0030867	rough endoplasmic reticulum membrane(GO:0030867)
0.0	0.1	GO:0000214	tRNA-intron endonuclease complex(GO:0000214)
0.0	0.1	GO:0046581	intercellular canaliculus(GO:0046581)
0.0	0.1	GO:0030532	small nuclear ribonucleoprotein complex(GO:0030532)
0.0	0.1	GO:0017071	intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.0	0.1	GO:0001652	granular component(GO:0001652)
0.0	0.0	GO:0097526	U4/U6 x U5 tri-snRNP complex(GO:0046540) spliceosomal tri-snRNP complex(GO:0097526)
0.0	0.1	GO:0048188	Set1C/COMPASS complex(GO:0048188)
0.0	0.2	GO:0043020	NADPH oxidase complex(GO:0043020)
0.0	0.2	GO:0005942	phosphatidylinositol 3-kinase complex(GO:0005942)
0.0	0.1	GO:0032040	small-subunit processome(GO:0032040)
0.0	0.4	GO:0033177	proton-transporting two-sector ATPase complex, proton-transporting domain(GO:0033177)
0.0	0.1	GO:0044224	juxtaparanode region of axon(GO:0044224)
0.0	0.1	GO:0016281	eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0	0.3	GO:0030530	obsolete heterogeneous nuclear ribonucleoprotein complex(GO:0030530)
0.0	0.6	GO:0005834	heterotrimeric G-protein complex(GO:0005834)
0.0	0.0	GO:0072487	MSL complex(GO:0072487)
0.0	0.1	GO:0000783	telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783)
0.0	0.9	GO:0000790	nuclear chromatin(GO:0000790)
0.0	0.7	GO:0009898	cytoplasmic side of plasma membrane(GO:0009898)
0.0	0.1	GO:0005838	proteasome regulatory particle(GO:0005838)
0.0	0.1	GO:0016272	prefoldin complex(GO:0016272)
0.0	0.1	GO:0005850	eukaryotic translation initiation factor 2 complex(GO:0005850)
0.0	0.2	GO:0032156	septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.0	0.0	GO:0033150	cytoskeletal calyx(GO:0033150)
0.0	0.1	GO:0036126	outer dense fiber(GO:0001520) sperm flagellum(GO:0036126)
0.0	0.1	GO:0042599	lamellar body(GO:0042599)
0.0	0.1	GO:0005672	transcription factor TFIIA complex(GO:0005672)
0.0	0.0	GO:0071001	U4/U6 snRNP(GO:0071001)
0.0	0.1	GO:0032590	dendrite membrane(GO:0032590)
0.0	0.4	GO:0016592	mediator complex(GO:0016592)
0.0	0.1	GO:0005885	Arp2/3 protein complex(GO:0005885)
0.0	0.5	GO:0017053	transcriptional repressor complex(GO:0017053)
0.0	0.1	GO:0035098	ESC/E(Z) complex(GO:0035098)
0.0	0.6	GO:0005778	peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0	0.0	GO:1903561	extracellular exosome(GO:0070062) extracellular vesicle(GO:1903561)
0.0	0.0	GO:0000778	condensed nuclear chromosome kinetochore(GO:0000778)
0.0	0.1	GO:0001772	immunological synapse(GO:0001772)
0.0	0.1	GO:0035145	exon-exon junction complex(GO:0035145)
0.0	0.2	GO:0005744	mitochondrial inner membrane presequence translocase complex(GO:0005744)
0.0	0.1	GO:0031362	anchored component of external side of plasma membrane(GO:0031362)
0.0	0.1	GO:0000792	heterochromatin(GO:0000792)
0.0	0.2	GO:0005669	transcription factor TFIID complex(GO:0005669)
0.0	0.6	GO:0016605	PML body(GO:0016605)
0.0	0.1	GO:0042598	obsolete vesicular fraction(GO:0042598)
0.0	0.7	GO:0000786	nucleosome(GO:0000786)
0.0	0.1	GO:0031304	intrinsic component of mitochondrial inner membrane(GO:0031304)
0.0	0.0	GO:0031932	TORC2 complex(GO:0031932)
0.0	0.0	GO:0032299	ribonuclease H2 complex(GO:0032299)
0.0	0.2	GO:0033017	sarcoplasmic reticulum membrane(GO:0033017)
0.0	0.0	GO:0005945	6-phosphofructokinase complex(GO:0005945)
0.0	0.1	GO:0031588	nucleotide-activated protein kinase complex(GO:0031588)
0.0	0.0	GO:0001950	obsolete plasma membrane enriched fraction(GO:0001950)
0.0	0.0	GO:0070188	obsolete Stn1-Ten1 complex(GO:0070188)
0.0	1.2	GO:0005681	spliceosomal complex(GO:0005681)
0.0	0.1	GO:0005915	zonula adherens(GO:0005915)
0.0	0.1	GO:0000796	condensin complex(GO:0000796)
0.0	0.0	GO:0031838	haptoglobin-hemoglobin complex(GO:0031838)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0005113	patched binding(GO:0005113)
0.1	0.3	GO:0004911	interleukin-2 receptor activity(GO:0004911)
0.1	0.2	GO:0051864	histone demethylase activity (H3-K36 specific)(GO:0051864)
0.1	0.2	GO:0030375	thyroid hormone receptor coactivator activity(GO:0030375)
0.1	0.3	GO:0032454	histone demethylase activity (H3-K9 specific)(GO:0032454)
0.1	0.2	GO:0016842	amidine-lyase activity(GO:0016842)
0.1	0.2	GO:0008454	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.1	0.2	GO:0098847	single-stranded telomeric DNA binding(GO:0043047) sequence-specific single stranded DNA binding(GO:0098847)
0.1	0.2	GO:0003726	double-stranded RNA adenosine deaminase activity(GO:0003726)
0.1	0.2	GO:0033743	peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.1	0.2	GO:0070053	thrombospondin receptor activity(GO:0070053)
0.1	0.2	GO:0004833	tryptophan 2,3-dioxygenase activity(GO:0004833)
0.1	0.2	GO:0008475	procollagen-lysine 5-dioxygenase activity(GO:0008475)
0.1	0.3	GO:0048156	tau protein binding(GO:0048156)
0.1	0.2	GO:0004865	protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.1	0.2	GO:0005047	signal recognition particle binding(GO:0005047)
0.1	0.2	GO:0004566	beta-glucuronidase activity(GO:0004566)
0.0	0.1	GO:0004321	fatty-acyl-CoA synthase activity(GO:0004321)
0.0	0.1	GO:0001849	complement component C1q binding(GO:0001849)
0.0	0.2	GO:0045569	TRAIL binding(GO:0045569)
0.0	0.2	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0	0.3	GO:0016417	S-acyltransferase activity(GO:0016417)
0.0	0.1	GO:0004591	oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.0	0.2	GO:0016494	C-X-C chemokine receptor activity(GO:0016494)
0.0	0.2	GO:0015065	uridine nucleotide receptor activity(GO:0015065) G-protein coupled pyrimidinergic nucleotide receptor activity(GO:0071553)
0.0	0.1	GO:0051880	G-quadruplex DNA binding(GO:0051880)
0.0	0.3	GO:0031701	angiotensin receptor binding(GO:0031701)
0.0	0.1	GO:0000064	L-ornithine transmembrane transporter activity(GO:0000064)
0.0	0.2	GO:0001727	lipid kinase activity(GO:0001727)
0.0	0.1	GO:0050544	arachidonic acid binding(GO:0050544)
0.0	0.2	GO:0016907	G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0	0.1	GO:0019531	oxalate transmembrane transporter activity(GO:0019531)
0.0	0.1	GO:0035184	histone threonine kinase activity(GO:0035184)
0.0	0.1	GO:0047631	ADP-ribose diphosphatase activity(GO:0047631)
0.0	0.3	GO:0000339	RNA cap binding(GO:0000339)
0.0	0.1	GO:0046404	ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734)
0.0	0.1	GO:0001848	complement binding(GO:0001848)
0.0	0.1	GO:0004340	glucokinase activity(GO:0004340)
0.0	0.5	GO:0005344	oxygen transporter activity(GO:0005344)
0.0	0.1	GO:0052834	inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate phosphatase activity(GO:0052834)
0.0	0.2	GO:0016421	CoA carboxylase activity(GO:0016421)
0.0	0.1	GO:0008331	high voltage-gated calcium channel activity(GO:0008331)
0.0	0.1	GO:0003873	6-phosphofructo-2-kinase activity(GO:0003873)
0.0	0.2	GO:0008568	microtubule-severing ATPase activity(GO:0008568)
0.0	0.1	GO:0016312	inositol bisphosphate phosphatase activity(GO:0016312)
0.0	0.1	GO:0035197	siRNA binding(GO:0035197)
0.0	0.1	GO:0019136	deoxynucleoside kinase activity(GO:0019136)
0.0	0.1	GO:0043141	ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.0	0.2	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.0	0.2	GO:0019789	SUMO transferase activity(GO:0019789)
0.0	0.2	GO:0016671	oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor(GO:0016671)
0.0	0.1	GO:0033691	sialic acid binding(GO:0033691)
0.0	0.3	GO:0015924	mannosyl-oligosaccharide mannosidase activity(GO:0015924)
0.0	0.1	GO:0030229	very-low-density lipoprotein particle receptor activity(GO:0030229)
0.0	0.1	GO:0004142	diacylglycerol cholinephosphotransferase activity(GO:0004142)
0.0	0.0	GO:0001099	basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.0	0.2	GO:0001085	RNA polymerase II transcription factor binding(GO:0001085)
0.0	0.2	GO:0050700	CARD domain binding(GO:0050700)
0.0	0.2	GO:0015279	store-operated calcium channel activity(GO:0015279)
0.0	0.1	GO:0004514	nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514)
0.0	0.1	GO:0004813	alanine-tRNA ligase activity(GO:0004813)
0.0	0.1	GO:0070579	methylcytosine dioxygenase activity(GO:0070579)
0.0	0.3	GO:0004690	cyclic nucleotide-dependent protein kinase activity(GO:0004690)
0.0	0.1	GO:0030955	potassium ion binding(GO:0030955)
0.0	0.4	GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656)
0.0	0.1	GO:0003953	NAD+ nucleosidase activity(GO:0003953)
0.0	0.1	GO:0033300	dehydroascorbic acid transporter activity(GO:0033300)
0.0	0.3	GO:0043560	insulin receptor substrate binding(GO:0043560)
0.0	0.5	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0	0.1	GO:0032450	maltose alpha-glucosidase activity(GO:0032450)
0.0	0.1	GO:0003960	NADPH:quinone reductase activity(GO:0003960)
0.0	0.0	GO:0004396	hexokinase activity(GO:0004396)
0.0	0.1	GO:0015226	amino-acid betaine transmembrane transporter activity(GO:0015199) carnitine transmembrane transporter activity(GO:0015226)
0.0	0.1	GO:0043422	protein kinase B binding(GO:0043422)
0.0	0.1	GO:0004448	isocitrate dehydrogenase activity(GO:0004448)
0.0	0.2	GO:0016565	obsolete general transcriptional repressor activity(GO:0016565)
0.0	0.1	GO:0019863	IgE binding(GO:0019863)
0.0	0.3	GO:0016493	C-C chemokine receptor activity(GO:0016493)
0.0	0.1	GO:0008109	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0	0.1	GO:0005381	iron ion transmembrane transporter activity(GO:0005381)
0.0	0.1	GO:0004974	leukotriene receptor activity(GO:0004974)
0.0	0.2	GO:0004716	receptor signaling protein tyrosine kinase activity(GO:0004716)
0.0	0.2	GO:0030676	Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0	0.1	GO:0015379	potassium:chloride symporter activity(GO:0015379)
0.0	0.2	GO:0015347	sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.0	0.1	GO:0005087	Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.0	0.2	GO:0016175	superoxide-generating NADPH oxidase activity(GO:0016175)
0.0	0.2	GO:0043425	bHLH transcription factor binding(GO:0043425)
0.0	0.2	GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0	0.1	GO:0071723	lipopeptide binding(GO:0071723)
0.0	0.1	GO:0047035	testosterone dehydrogenase (NAD+) activity(GO:0047035)
0.0	0.1	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.0	0.3	GO:0070064	proline-rich region binding(GO:0070064)
0.0	0.1	GO:0031957	very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0	0.1	GO:0004982	N-formyl peptide receptor activity(GO:0004982)
0.0	0.1	GO:0004060	arylamine N-acetyltransferase activity(GO:0004060)
0.0	0.3	GO:0016805	dipeptidase activity(GO:0016805)
0.0	0.3	GO:0010181	FMN binding(GO:0010181)
0.0	0.3	GO:0070412	R-SMAD binding(GO:0070412)
0.0	0.0	GO:0005275	amine transmembrane transporter activity(GO:0005275)
0.0	0.1	GO:0008745	N-acetylmuramoyl-L-alanine amidase activity(GO:0008745)
0.0	0.1	GO:0004994	somatostatin receptor activity(GO:0004994)
0.0	0.1	GO:0004046	aminoacylase activity(GO:0004046)
0.0	0.0	GO:0042806	fucose binding(GO:0042806)
0.0	0.0	GO:0070052	collagen V binding(GO:0070052)
0.0	0.1	GO:0000900	translation repressor activity, nucleic acid binding(GO:0000900)
0.0	0.1	GO:0070402	NADPH binding(GO:0070402)
0.0	0.2	GO:0019200	carbohydrate kinase activity(GO:0019200)
0.0	0.1	GO:0016889	endodeoxyribonuclease activity, producing 3'-phosphomonoesters(GO:0016889)
0.0	0.1	GO:0050265	RNA uridylyltransferase activity(GO:0050265)
0.0	0.1	GO:0004030	aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.0	0.2	GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0	0.0	GO:0046975	histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.0	0.0	GO:0016748	succinyltransferase activity(GO:0016748)
0.0	0.1	GO:0016509	long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0016509)
0.0	0.1	GO:0008266	poly(U) RNA binding(GO:0008266)
0.0	0.1	GO:0016624	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor(GO:0016624)
0.0	0.4	GO:0004298	threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0	0.1	GO:0015038	glutathione disulfide oxidoreductase activity(GO:0015038)
0.0	0.1	GO:0042156	obsolete zinc-mediated transcriptional activator activity(GO:0042156)
0.0	0.2	GO:0070888	E-box binding(GO:0070888)
0.0	0.1	GO:0004596	peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0	0.0	GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.0	0.1	GO:0070016	armadillo repeat domain binding(GO:0070016)
0.0	0.1	GO:0004704	NF-kappaB-inducing kinase activity(GO:0004704)
0.0	0.1	GO:0045236	CXCR chemokine receptor binding(GO:0045236)
0.0	0.1	GO:0015271	outward rectifier potassium channel activity(GO:0015271)
0.0	0.1	GO:0033829	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.0	0.3	GO:0043499	obsolete eukaryotic cell surface binding(GO:0043499)
0.0	0.1	GO:0031685	adenosine receptor binding(GO:0031685)
0.0	0.1	GO:0030507	spectrin binding(GO:0030507)
0.0	0.1	GO:0004467	long-chain fatty acid-CoA ligase activity(GO:0004467)
0.0	0.1	GO:0034235	GPI anchor binding(GO:0034235)
0.0	0.1	GO:0042800	histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0	0.1	GO:0070273	phosphatidylinositol-4-phosphate binding(GO:0070273)
0.0	0.3	GO:0004709	MAP kinase kinase kinase activity(GO:0004709)
0.0	0.1	GO:0004748	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.0	0.1	GO:0005049	nuclear export signal receptor activity(GO:0005049)
0.0	0.3	GO:0008186	RNA-dependent ATPase activity(GO:0008186)
0.0	0.1	GO:0004594	pantothenate kinase activity(GO:0004594)
0.0	0.1	GO:0004045	aminoacyl-tRNA hydrolase activity(GO:0004045)
0.0	0.4	GO:0005048	signal sequence binding(GO:0005048)
0.0	0.1	GO:0030292	protein tyrosine kinase inhibitor activity(GO:0030292)
0.0	0.3	GO:0004708	MAP kinase kinase activity(GO:0004708)
0.0	0.3	GO:0043621	protein self-association(GO:0043621)
0.0	0.1	GO:0004103	choline kinase activity(GO:0004103)
0.0	0.1	GO:0098599	palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0	0.2	GO:0030169	low-density lipoprotein particle binding(GO:0030169)
0.0	0.2	GO:0003796	lysozyme activity(GO:0003796)
0.0	0.1	GO:0017162	aryl hydrocarbon receptor binding(GO:0017162)
0.0	0.1	GO:0008296	3'-5'-exodeoxyribonuclease activity(GO:0008296)
0.0	0.2	GO:0016986	obsolete transcription initiation factor activity(GO:0016986)
0.0	0.1	GO:0070548	L-glutamine aminotransferase activity(GO:0070548)
0.0	0.1	GO:0031543	peptidyl-proline dioxygenase activity(GO:0031543)
0.0	0.1	GO:0004957	prostaglandin E receptor activity(GO:0004957)
0.0	0.1	GO:0016647	oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.0	0.2	GO:0008171	O-methyltransferase activity(GO:0008171)
0.0	0.1	GO:0031996	thioesterase binding(GO:0031996)
0.0	0.2	GO:0043015	gamma-tubulin binding(GO:0043015)
0.0	0.0	GO:0017159	pantetheine hydrolase activity(GO:0017159)
0.0	0.0	GO:0000400	four-way junction DNA binding(GO:0000400)
0.0	0.1	GO:0017049	GTP-Rho binding(GO:0017049)
0.0	0.1	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0	0.0	GO:0008327	methyl-CpG binding(GO:0008327)
0.0	0.0	GO:0016972	thiol oxidase activity(GO:0016972)
0.0	0.1	GO:0000014	single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.0	0.3	GO:0005164	tumor necrosis factor receptor binding(GO:0005164)
0.0	0.0	GO:0016309	1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0	0.1	GO:0004703	G-protein coupled receptor kinase activity(GO:0004703)
0.0	0.1	GO:0042392	sphingosine-1-phosphate phosphatase activity(GO:0042392)
0.0	0.0	GO:0042799	histone methyltransferase activity (H4-K20 specific)(GO:0042799)
0.0	0.1	GO:0005522	profilin binding(GO:0005522)
0.0	0.2	GO:0009982	pseudouridine synthase activity(GO:0009982)
0.0	0.3	GO:0016675	cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0	0.1	GO:0019992	diacylglycerol binding(GO:0019992)
0.0	0.3	GO:0019212	phosphatase inhibitor activity(GO:0019212)
0.0	0.1	GO:0008420	CTD phosphatase activity(GO:0008420)
0.0	0.2	GO:0005095	GTPase inhibitor activity(GO:0005095)
0.0	0.2	GO:0051537	2 iron, 2 sulfur cluster binding(GO:0051537)
0.0	0.1	GO:0016922	ligand-dependent nuclear receptor binding(GO:0016922)
0.0	0.0	GO:0004607	phosphatidylcholine-sterol O-acyltransferase activity(GO:0004607)
0.0	0.1	GO:0003810	protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0	0.3	GO:0001608	G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0	0.1	GO:0030276	clathrin binding(GO:0030276)
0.0	0.1	GO:0015925	galactosidase activity(GO:0015925)
0.0	0.0	GO:0001846	opsonin binding(GO:0001846)
0.0	0.0	GO:0098518	polynucleotide phosphatase activity(GO:0098518)
0.0	0.1	GO:0050998	nitric-oxide synthase binding(GO:0050998)
0.0	0.1	GO:0046974	histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.0	0.4	GO:0002039	p53 binding(GO:0002039)
0.0	0.2	GO:0016780	phosphotransferase activity, for other substituted phosphate groups(GO:0016780)
0.0	0.0	GO:0005094	Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0	0.1	GO:0008467	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0	0.1	GO:0032452	histone demethylase activity(GO:0032452)
0.0	0.1	GO:0045309	protein phosphorylated amino acid binding(GO:0045309)
0.0	0.2	GO:0004707	MAP kinase activity(GO:0004707)
0.0	0.1	GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) lysophosphatidic acid acyltransferase activity(GO:0042171) lysophospholipid acyltransferase activity(GO:0071617)
0.0	0.1	GO:0008253	5'-nucleotidase activity(GO:0008253)
0.0	0.0	GO:0004370	glycerol kinase activity(GO:0004370)
0.0	0.1	GO:0019788	NEDD8 transferase activity(GO:0019788)
0.0	0.1	GO:0043495	protein anchor(GO:0043495)
0.0	0.2	GO:0016892	endoribonuclease activity, producing 3'-phosphomonoesters(GO:0016892)
0.0	0.0	GO:0008853	exodeoxyribonuclease III activity(GO:0008853)
0.0	0.1	GO:0003986	acetyl-CoA hydrolase activity(GO:0003986)
0.0	0.1	GO:0004697	protein kinase C activity(GO:0004697)
0.0	0.0	GO:0034594	phosphatidylinositol trisphosphate phosphatase activity(GO:0034594)
0.0	0.2	GO:0005528	macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0	0.4	GO:0001104	transcription factor activity, RNA polymerase II transcription factor binding(GO:0001076) RNA polymerase II transcription cofactor activity(GO:0001104)
0.0	0.3	GO:0019003	GDP binding(GO:0019003)
0.0	0.1	GO:0000062	fatty-acyl-CoA binding(GO:0000062)
0.0	0.1	GO:0034237	protein kinase A regulatory subunit binding(GO:0034237)
0.0	0.0	GO:0042608	T cell receptor binding(GO:0042608)
0.0	0.3	GO:0003950	NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0	0.0	GO:0050220	prostaglandin-E synthase activity(GO:0050220)
0.0	0.1	GO:0090482	vitamin transmembrane transporter activity(GO:0090482)
0.0	0.0	GO:0030247	pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0	0.1	GO:0016864	protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.0	0.1	GO:0004127	cytidylate kinase activity(GO:0004127)
0.0	0.1	GO:0017069	snRNA binding(GO:0017069)
0.0	0.0	GO:0036002	pre-mRNA binding(GO:0036002)
0.0	0.0	GO:0004528	phosphodiesterase I activity(GO:0004528)
0.0	0.1	GO:0015450	P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.0	0.3	GO:0005109	frizzled binding(GO:0005109)
0.0	0.1	GO:0017127	cholesterol transporter activity(GO:0017127)
0.0	0.0	GO:0003829	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0003829)
0.0	0.0	GO:0042289	MHC class II protein binding(GO:0042289)
0.0	0.1	GO:0004385	guanylate kinase activity(GO:0004385)
0.0	0.1	GO:0070567	cytidylyltransferase activity(GO:0070567)
0.0	0.1	GO:0008536	Ran GTPase binding(GO:0008536)
0.0	0.1	GO:0030306	ADP-ribosylation factor binding(GO:0030306)
0.0	0.6	GO:0042393	histone binding(GO:0042393)
0.0	0.0	GO:0004999	vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.0	0.1	GO:0016520	growth hormone-releasing hormone receptor activity(GO:0016520)
0.0	0.0	GO:0005134	interleukin-2 receptor binding(GO:0005134)
0.0	0.2	GO:0050699	WW domain binding(GO:0050699)
0.0	0.0	GO:0047238	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.0	0.1	GO:0001540	beta-amyloid binding(GO:0001540)
0.0	0.0	GO:0004992	platelet activating factor receptor activity(GO:0004992)
0.0	0.1	GO:0080025	phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0	0.3	GO:0016831	carboxy-lyase activity(GO:0016831)
0.0	0.0	GO:0070097	delta-catenin binding(GO:0070097)
0.0	0.0	GO:0002060	purine nucleobase binding(GO:0002060)
0.0	0.1	GO:0003857	3-hydroxyacyl-CoA dehydrogenase activity(GO:0003857)
0.0	0.4	GO:0005044	scavenger receptor activity(GO:0005044)
0.0	0.1	GO:0004904	interferon receptor activity(GO:0004904)
0.0	0.0	GO:0070492	oligosaccharide binding(GO:0070492)
0.0	0.0	GO:0004803	transposase activity(GO:0004803)
0.0	0.1	GO:0015232	heme transporter activity(GO:0015232)
0.0	0.0	GO:0004873	asialoglycoprotein receptor activity(GO:0004873)
0.0	0.1	GO:0004176	ATP-dependent peptidase activity(GO:0004176)
0.0	0.0	GO:0008379	thioredoxin peroxidase activity(GO:0008379)
0.0	0.0	GO:0008486	diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486)
0.0	0.1	GO:0004602	glutathione peroxidase activity(GO:0004602)
0.0	0.1	GO:0008430	selenium binding(GO:0008430)
0.0	0.0	GO:0043024	ribosomal small subunit binding(GO:0043024)
0.0	0.0	GO:0005222	intracellular cAMP activated cation channel activity(GO:0005222)
0.0	0.0	GO:0008192	RNA guanylyltransferase activity(GO:0008192)
0.0	0.1	GO:0017075	syntaxin-1 binding(GO:0017075)
0.0	0.0	GO:0071208	histone pre-mRNA DCP binding(GO:0071208)
0.0	0.0	GO:0032558	purine deoxyribonucleotide binding(GO:0032554) adenyl deoxyribonucleotide binding(GO:0032558)
0.0	0.5	GO:0050660	flavin adenine dinucleotide binding(GO:0050660)
0.0	0.0	GO:0031708	bombesin receptor binding(GO:0031705) endothelin B receptor binding(GO:0031708)
0.0	0.0	GO:0016635	oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor(GO:0016635)
0.0	0.0	GO:0004465	lipoprotein lipase activity(GO:0004465)
0.0	0.1	GO:0005221	intracellular cyclic nucleotide activated cation channel activity(GO:0005221) cyclic nucleotide-gated ion channel activity(GO:0043855)
0.0	0.0	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977) RNA polymerase II regulatory region DNA binding(GO:0001012)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.1	ST G ALPHA S PATHWAY	G alpha s Pathway
0.6	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.6	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.9	PID IL8 CXCR1 PATHWAY	IL8- and CXCR1-mediated signaling events
0.3	PID INTEGRIN3 PATHWAY	Beta3 integrin cell surface interactions
0.4	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
0.4	PID RANBP2 PATHWAY	Sumoylation by RanBP2 regulates transcriptional repression
1.6	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
0.6	ST TUMOR NECROSIS FACTOR PATHWAY	Tumor Necrosis Factor Pathway.
0.4	PID NFKAPPAB CANONICAL PATHWAY	Canonical NF-kappaB pathway
0.2	PID HIV NEF PATHWAY	HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.4	PID ERB GENOMIC PATHWAY	Validated nuclear estrogen receptor beta network
0.5	PID P38 MKK3 6PATHWAY	p38 MAPK signaling pathway
0.0	ST GRANULE CELL SURVIVAL PATHWAY	Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.1	PID NFKAPPAB ATYPICAL PATHWAY	Atypical NF-kappaB pathway
0.8	PID TXA2PATHWAY	Thromboxane A2 receptor signaling
0.1	PID CD8 TCR PATHWAY	TCR signaling in naïve CD8+ T cells
0.0	PID GMCSF PATHWAY	GMCSF-mediated signaling events
0.3	PID TRAIL PATHWAY	TRAIL signaling pathway
0.3	SA CASPASE CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.5	PID BCR 5PATHWAY	BCR signaling pathway
0.3	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.4	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.3	PID RAS PATHWAY	Regulation of Ras family activation
0.2	SIG PIP3 SIGNALING IN B LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes
0.2	PID IL8 CXCR2 PATHWAY	IL8- and CXCR2-mediated signaling events
0.2	PID ER NONGENOMIC PATHWAY	Plasma membrane estrogen receptor signaling
0.3	PID IL12 STAT4 PATHWAY	IL12 signaling mediated by STAT4
0.2	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0	ST DIFFERENTIATION PATHWAY IN PC12 CELLS	Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.4	ST PHOSPHOINOSITIDE 3 KINASE PATHWAY	PI3K Pathway
0.2	PID RB 1PATHWAY	Regulation of retinoblastoma protein
0.1	SA B CELL RECEPTOR COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.4	PID ECADHERIN NASCENT AJ PATHWAY	E-cadherin signaling in the nascent adherens junction
0.5	PID P38 ALPHA BETA DOWNSTREAM PATHWAY	Signaling mediated by p38-alpha and p38-beta
0.2	ST JNK MAPK PATHWAY	JNK MAPK Pathway
0.4	PID FOXO PATHWAY	FoxO family signaling
0.1	PID IL2 PI3K PATHWAY	IL2 signaling events mediated by PI3K
0.7	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network
0.1	PID P38 ALPHA BETA PATHWAY	Regulation of p38-alpha and p38-beta
0.6	PID MYC REPRESS PATHWAY	Validated targets of C-MYC transcriptional repression
0.1	PID PI3KCI PATHWAY	Class I PI3K signaling events
0.2	PID S1P META PATHWAY	Sphingosine 1-phosphate (S1P) pathway
0.1	PID IL5 PATHWAY	IL5-mediated signaling events
0.4	PID P53 REGULATION PATHWAY	p53 pathway
0.1	ST IL 13 PATHWAY	Interleukin 13 (IL-13) Pathway
0.2	PID REG GR PATHWAY	Glucocorticoid receptor regulatory network
0.2	PID CERAMIDE PATHWAY	Ceramide signaling pathway
0.1	PID IL2 1PATHWAY	IL2-mediated signaling events
0.0	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
0.2	PID WNT NONCANONICAL PATHWAY	Noncanonical Wnt signaling pathway
0.1	PID MYC PATHWAY	C-MYC pathway
0.0	PID ARF6 DOWNSTREAM PATHWAY	Arf6 downstream pathway
0.2	PID ERBB1 INTERNALIZATION PATHWAY	Internalization of ErbB1

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.1	0.6	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.0	0.0	REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS	Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.0	0.0	REACTOME SIGNALING BY THE B CELL RECEPTOR BCR	Genes involved in Signaling by the B Cell Receptor (BCR)
0.0	0.4	REACTOME RAF MAP KINASE CASCADE	Genes involved in RAF/MAP kinase cascade
0.0	0.4	REACTOME REGULATION OF SIGNALING BY CBL	Genes involved in Regulation of signaling by CBL
0.0	0.5	REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0	0.5	REACTOME N GLYCAN ANTENNAE ELONGATION	Genes involved in N-Glycan antennae elongation
0.0	0.1	REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX	Genes involved in Association of licensing factors with the pre-replicative complex
0.0	0.1	REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI	Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.0	0.1	REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1	Genes involved in Regulation of AMPK activity via LKB1
0.0	0.3	REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0	0.9	REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0	0.0	REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS	Genes involved in Elevation of cytosolic Ca2+ levels
0.0	0.0	REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0	1.2	REACTOME TCR SIGNALING	Genes involved in TCR signaling
0.0	0.3	REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX	Genes involved in CDC6 association with the ORC:origin complex
0.0	0.5	REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI	Genes involved in RIP-mediated NFkB activation via DAI
0.0	0.5	REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE	Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0	0.5	REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE	Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0	0.2	REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION	Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0	0.1	REACTOME ACTIVATION OF NF KAPPAB IN B CELLS	Genes involved in Activation of NF-kappaB in B Cells
0.0	1.7	REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION	Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0	0.3	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.0	0.0	REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR	Genes involved in Thromboxane signalling through TP receptor
0.0	0.1	REACTOME IRAK1 RECRUITS IKK COMPLEX	Genes involved in IRAK1 recruits IKK complex
0.0	0.2	REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION	Genes involved in activated TAK1 mediates p38 MAPK activation
0.0	0.2	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING	Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.0	0.3	REACTOME RAP1 SIGNALLING	Genes involved in Rap1 signalling
0.0	0.6	REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING	Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0	0.5	REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0	0.4	REACTOME G PROTEIN BETA GAMMA SIGNALLING	Genes involved in G-protein beta:gamma signalling
0.0	0.2	REACTOME CTNNB1 PHOSPHORYLATION CASCADE	Genes involved in Beta-catenin phosphorylation cascade
0.0	0.2	REACTOME P2Y RECEPTORS	Genes involved in P2Y receptors
0.0	0.0	REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING	Genes involved in Advanced glycosylation endproduct receptor signaling
0.0	0.2	REACTOME PURINE CATABOLISM	Genes involved in Purine catabolism
0.0	0.2	REACTOME TRYPTOPHAN CATABOLISM	Genes involved in Tryptophan catabolism
0.0	0.0	REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS	Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.0	0.1	REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK	Genes involved in Negative regulation of the PI3K/AKT network
0.0	0.2	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.0	0.2	REACTOME GLUCOSE TRANSPORT	Genes involved in Glucose transport
0.0	0.2	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade
0.0	0.6	REACTOME G ALPHA1213 SIGNALLING EVENTS	Genes involved in G alpha (12/13) signalling events
0.0	0.1	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.0	0.9	REACTOME P53 DEPENDENT G1 DNA DAMAGE RESPONSE	Genes involved in p53-Dependent G1 DNA Damage Response
0.0	0.2	REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS	Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0	0.2	REACTOME TRANSPORT OF ORGANIC ANIONS	Genes involved in Transport of organic anions
0.0	0.6	REACTOME MYD88 MAL CASCADE INITIATED ON PLASMA MEMBRANE	Genes involved in MyD88:Mal cascade initiated on plasma membrane
0.0	0.3	REACTOME LYSOSOME VESICLE BIOGENESIS	Genes involved in Lysosome Vesicle Biogenesis
0.0	0.2	REACTOME SIGNALING BY FGFR1 FUSION MUTANTS	Genes involved in Signaling by FGFR1 fusion mutants
0.0	0.0	REACTOME BILE ACID AND BILE SALT METABOLISM	Genes involved in Bile acid and bile salt metabolism
0.0	0.3	REACTOME RNA POL I PROMOTER OPENING	Genes involved in RNA Polymerase I Promoter Opening
0.0	0.0	REACTOME CTLA4 INHIBITORY SIGNALING	Genes involved in CTLA4 inhibitory signaling
0.0	0.1	REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS	Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.0	0.2	REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS	Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0	0.3	REACTOME CYTOSOLIC TRNA AMINOACYLATION	Genes involved in Cytosolic tRNA aminoacylation
0.0	0.2	REACTOME EFFECTS OF PIP2 HYDROLYSIS	Genes involved in Effects of PIP2 hydrolysis
0.0	0.0	REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY	Genes involved in TRAF3-dependent IRF activation pathway
0.0	0.3	REACTOME INSULIN RECEPTOR RECYCLING	Genes involved in Insulin receptor recycling
0.0	0.2	REACTOME EICOSANOID LIGAND BINDING RECEPTORS	Genes involved in Eicosanoid ligand-binding receptors
0.0	0.2	REACTOME CALNEXIN CALRETICULIN CYCLE	Genes involved in Calnexin/calreticulin cycle
0.0	0.0	REACTOME DESTABILIZATION OF MRNA BY KSRP	Genes involved in Destabilization of mRNA by KSRP
0.0	0.6	REACTOME PACKAGING OF TELOMERE ENDS	Genes involved in Packaging Of Telomere Ends
0.0	0.0	REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES	Genes involved in p75NTR recruits signalling complexes
0.0	0.1	REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL	Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.0	0.6	REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES	Genes involved in Antiviral mechanism by IFN-stimulated genes
0.0	0.2	REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION	Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0	0.1	REACTOME REGULATION OF IFNG SIGNALING	Genes involved in Regulation of IFNG signaling
0.0	0.2	REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING	Genes involved in Formation of ATP by chemiosmotic coupling
0.0	0.3	REACTOME ACYL CHAIN REMODELLING OF PE	Genes involved in Acyl chain remodelling of PE
0.0	0.2	REACTOME SYNTHESIS OF PC	Genes involved in Synthesis of PC
0.0	0.1	REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE	Genes involved in Synthesis of PIPs at the late endosome membrane
0.0	0.0	REACTOME PROCESSING OF CAPPED INTRONLESS PRE MRNA	Genes involved in Processing of Capped Intronless Pre-mRNA
0.0	0.1	REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT	Genes involved in Organic cation/anion/zwitterion transport
0.0	0.6	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0	0.3	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
0.0	0.3	REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC	Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
0.0	0.0	REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0	Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
0.0	0.2	REACTOME VIRAL MESSENGER RNA SYNTHESIS	Genes involved in Viral Messenger RNA Synthesis
0.0	0.2	REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	Genes involved in Regulation of gene expression in beta cells
0.0	0.1	REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS	Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0	0.1	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.0	0.2	REACTOME IL1 SIGNALING	Genes involved in Interleukin-1 signaling
0.0	0.0	REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION	Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0	0.1	REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION	Genes involved in Apoptosis induced DNA fragmentation
0.0	0.0	REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING	Genes involved in Transferrin endocytosis and recycling

Results for PITX2

Z-value: 2.34

Motif logo

Transcription factors associated with PITX2

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Activity of the PITX2 motif across conditions

Conditions sorted by the z-value of the PITX2 motif activity

Top target CREs of the motif:

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of PITX2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: