CREMA results: PKNOX2

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Transcription factors associated with PKNOX2

Gene Symbol	Gene ID	Gene Info
PKNOX2 Ensembl NCBI GeneCards UniProt	ENSG00000165495.11	PBX/knotted 1 homeobox 2

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

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CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
chr11_125035327_125035515	PKNOX2	771	0.434680	0.69	3.8e-02	Click!
chr11_125046475_125046626	PKNOX2	7533	0.158988	0.77	1.4e-02	Click!
chr11_125047215_125047366	PKNOX2	6793	0.161839	0.66	5.3e-02	Click!
chr11_125234303_125234454	PKNOX2	34223	0.161045	0.75	2.0e-02	Click!
chr11_125246240_125246391	PKNOX2	46160	0.132456	0.67	5.0e-02	Click!

Showing 1 to 5 of 5 entries

Activity of the PKNOX2 motif across conditions

Conditions sorted by the z-value of the PKNOX2 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

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Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr13_50144464_50144942	0.41	RCBTB1	regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1	3244	0.28
chr10_77793698_77793895	0.36	ENSG00000221232	.	93273	0.09
chr7_30266553_30266704	0.35	ZNRF2	zinc and ring finger 2	57295	0.1
chr8_62621150_62621301	0.35	ASPH	aspartate beta-hydroxylase	5859	0.24
chr9_37998944_37999499	0.35	ENSG00000251745	.	62456	0.11
chr14_103452871_103453087	0.34	CDC42BPB	CDC42 binding protein kinase beta (DMPK-like)	18110	0.17
chr2_196440572_196441282	0.31	SLC39A10	solute carrier family 39 (zinc transporter), member 10	226	0.96
chr6_82732173_82732324	0.30	ENSG00000223044	.	187909	0.03
chr1_66258245_66258475	0.29	PDE4B	phosphodiesterase 4B, cAMP-specific	163	0.97
chr5_169380510_169380661	0.29	FAM196B	family with sequence similarity 196, member B	27159	0.22

Showing 1 to 10 of 200 entries

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of PKNOX2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.3	GO:0006198	cAMP catabolic process(GO:0006198)
0.0	0.3	GO:0000188	inactivation of MAPK activity(GO:0000188)
0.0	0.3	GO:0006829	zinc II ion transport(GO:0006829)
0.0	0.2	GO:0043497	regulation of protein heterodimerization activity(GO:0043497)
0.0	0.2	GO:0007185	transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0	0.2	GO:0016255	attachment of GPI anchor to protein(GO:0016255)
0.0	0.2	GO:0032986	nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.0	0.2	GO:0008045	motor neuron axon guidance(GO:0008045)
0.0	0.2	GO:0000731	DNA synthesis involved in DNA repair(GO:0000731)
0.1	0.1	GO:0002043	blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)

Showing 1 to 10 of 118 entries

Gene overrepresentation in cellular component category:

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Total log-likelihood	Term	Description
0.4	GO:0005626	obsolete insoluble fraction(GO:0005626)
0.2	GO:0042765	GPI-anchor transamidase complex(GO:0042765)
0.2	GO:0005719	nuclear euchromatin(GO:0005719)
0.2	GO:0005652	nuclear lamina(GO:0005652)
0.2	GO:0071564	npBAF complex(GO:0071564)
0.2	GO:0080008	Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.1	GO:0072379	BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.1	GO:0043259	laminin-10 complex(GO:0043259)
0.1	GO:0009331	glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.1	GO:0071204	histone pre-mRNA 3'end processing complex(GO:0071204)

Showing 1 to 10 of 31 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.3	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.1	0.2	GO:0030297	transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.1	0.2	GO:0005173	stem cell factor receptor binding(GO:0005173)
0.1	0.2	GO:0016149	translation release factor activity, codon specific(GO:0016149)
0.0	0.2	GO:0003923	GPI-anchor transamidase activity(GO:0003923)
0.0	0.2	GO:0019211	phosphatase activator activity(GO:0019211)
0.0	0.2	GO:0017169	CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.0	0.2	GO:0030332	cyclin binding(GO:0030332)
0.0	0.2	GO:0008353	RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.0	0.2	GO:0004653	polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)

Showing 1 to 10 of 79 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Total log-likelihood	Term	Description
0.4	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.4	PID HNF3A PATHWAY	FOXA1 transcription factor network
0.3	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
0.3	PID ALK1 PATHWAY	ALK1 signaling events
0.2	PID ARF6 DOWNSTREAM PATHWAY	Arf6 downstream pathway
0.1	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1	PID S1P S1P4 PATHWAY	S1P4 pathway
0.1	PID NETRIN PATHWAY	Netrin-mediated signaling events
0.0	PID MET PATHWAY	Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.0	SA CASPASE CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.

Showing 1 to 10 of 10 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Total log-likelihood	Term	Description
0.3	REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING	Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.3	REACTOME ZINC TRANSPORTERS	Genes involved in Zinc transporters
0.3	REACTOME ENOS ACTIVATION AND REGULATION	Genes involved in eNOS activation and regulation
0.3	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.2	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.2	REACTOME OTHER SEMAPHORIN INTERACTIONS	Genes involved in Other semaphorin interactions
0.2	REACTOME SIGNALING BY NOTCH4	Genes involved in Signaling by NOTCH4
0.2	REACTOME DESTABILIZATION OF MRNA BY KSRP	Genes involved in Destabilization of mRNA by KSRP
0.2	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade
0.1	REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES	Genes involved in Recruitment of NuMA to mitotic centrosomes

Showing 1 to 10 of 14 entries

Results for PKNOX2

Z-value: 0.90

Motif logo

Transcription factors associated with PKNOX2

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Activity of the PKNOX2 motif across conditions

Conditions sorted by the z-value of the PKNOX2 motif activity

Top target CREs of the motif:

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of PKNOX2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: