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ENCODE: H3K4me1 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for PKNOX2

Z-value: 0.90

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Transcription factors associated with PKNOX2

Gene Symbol	Gene ID	Gene Info
PKNOX2 Ensembl NCBI GeneCards UniProt	ENSG00000165495.11	PKNOX2

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
PKNOX2	chr11_125046475_125046626	7533	0.158988	0.77	1.4e-02	Click!
PKNOX2	chr11_125234303_125234454	34223	0.161045	0.75	2.0e-02	Click!
PKNOX2	chr11_125035327_125035515	771	0.434680	0.69	3.8e-02	Click!
PKNOX2	chr11_125246240_125246391	46160	0.132456	0.67	5.0e-02	Click!
PKNOX2	chr11_125047215_125047366	6793	0.161839	0.66	5.3e-02	Click!

Activity of the PKNOX2 motif across conditions

Conditions sorted by the z-value of the PKNOX2 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr13_50144464_50144942	0.41	RCBTB1	regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1	3244	0.28
chr10_77793698_77793895	0.36	ENSG00000221232	.	93273	0.09
chr7_30266553_30266704	0.35	ZNRF2	zinc and ring finger 2	57295	0.1
chr8_62621150_62621301	0.35	ASPH	aspartate beta-hydroxylase	5859	0.24
chr9_37998944_37999499	0.35	ENSG00000251745	.	62456	0.11
chr14_103452871_103453087	0.34	CDC42BPB	CDC42 binding protein kinase beta (DMPK-like)	18110	0.17
chr2_196440572_196441282	0.31	SLC39A10	solute carrier family 39 (zinc transporter), member 10	226	0.96
chr6_82732173_82732324	0.30	ENSG00000223044	.	187909	0.03
chr1_66258245_66258475	0.29	PDE4B	phosphodiesterase 4B, cAMP-specific	163	0.97
chr5_169380510_169380661	0.29	FAM196B	family with sequence similarity 196, member B	27159	0.22
chr6_13484408_13484559	0.28	AL583828.1		1932	0.24
chr6_36630267_36630418	0.28	ENSG00000251864	.	10273	0.14
chr11_94411215_94411366	0.28	AMOTL1	angiomotin like 1	28307	0.18
chr11_117812434_117812585	0.28	TMPRSS13	transmembrane protease, serine 13	12335	0.17
chr11_34225524_34225701	0.27	ENSG00000201867	.	14891	0.26
chr2_232164549_232164700	0.27	ARMC9	armadillo repeat containing 9	29379	0.17
chrX_153713483_153713883	0.27	UBL4A	ubiquitin-like 4A	1271	0.2
chr6_2798735_2799020	0.27	WRNIP1	Werner helicase interacting protein 1	29870	0.15
chr22_38618392_38618543	0.27	RP1-5O6.5		8859	0.11
chr11_128773402_128773673	0.27	C11orf45	chromosome 11 open reading frame 45	2055	0.28
chr4_157692338_157692515	0.26	RP11-154F14.2		70085	0.11
chr4_55685762_55685928	0.26	KIT	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	161760	0.04
chr1_64471981_64472261	0.26	ENSG00000207190	.	22551	0.22
chr9_113681977_113682128	0.26	ENSG00000207401	.	14634	0.21
chr7_116166986_116167137	0.26	CAV1	caveolin 1, caveolae protein, 22kDa	714	0.63
chr17_36981173_36981324	0.25	CWC25	CWC25 spliceosome-associated protein homolog (S. cerevisiae)	320	0.67
chr7_66205180_66205331	0.25	RP11-792A8.4		117	0.71
chr10_73532418_73532814	0.25	C10orf54	chromosome 10 open reading frame 54	639	0.72
chr20_22738676_22738827	0.25	ENSG00000265151	.	24812	0.26
chr2_237657369_237658039	0.25	ACKR3	atypical chemokine receptor 3	179420	0.03
chr11_18344519_18344871	0.24	GTF2H1	general transcription factor IIH, polypeptide 1, 62kDa	552	0.55
chr5_115827166_115827708	0.24	SEMA6A	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A	13064	0.24
chr16_68693085_68693236	0.24	RP11-615I2.2		13089	0.13
chr16_56945673_56945825	0.24	HERPUD1	homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1	20211	0.11
chr21_38903444_38903595	0.24	AP001421.1	Uncharacterized protein	14779	0.24
chr2_47401652_47401939	0.24	CALM2	calmodulin 2 (phosphorylase kinase, delta)	1855	0.37
chr7_23736580_23736769	0.24	STK31	serine/threonine kinase 31	13112	0.16
chr17_55521431_55521582	0.24	ENSG00000263902	.	31944	0.2
chr11_78139062_78139213	0.24	GAB2	GRB2-associated binding protein 2	9743	0.18
chr20_43968652_43968803	0.23	SDC4	syndecan 4	8337	0.12
chr12_52355616_52356045	0.23	ACVR1B	activin A receptor, type IB	8666	0.15
chr19_48836940_48837114	0.23	EMP3	epithelial membrane protein 3	8162	0.11
chr8_31497191_31497379	0.23	NRG1	neuregulin 1	14	0.99
chr9_137687858_137688009	0.23	COL5A1	collagen, type V, alpha 1	28557	0.09
chr10_3797419_3797677	0.23	RP11-184A2.3		4289	0.25
chr9_130308458_130308879	0.23	FAM129B	family with sequence similarity 129, member B	22699	0.15
chr3_70102890_70103041	0.23	MITF	microphthalmia-associated transcription factor	117091	0.06
chr2_16674927_16675078	0.23	AC104623.2		29442	0.25
chr3_194964658_194964809	0.23	XXYLT1	xyloside xylosyltransferase 1	3916	0.21
chr15_80354165_80354676	0.23	ZFAND6	zinc finger, AN1-type domain 6	1654	0.44
chr6_85483668_85483897	0.23	TBX18	T-box 18	9545	0.3
chr2_110402358_110402509	0.23	SOWAHC	sosondowah ankyrin repeat domain family member C	30522	0.16
chr4_103414906_103415100	0.23	AF213884.2		7473	0.22
chr17_39650766_39650917	0.22	KRT36	keratin 36	2043	0.14
chr2_241525444_241525595	0.22	CAPN10-AS1	CAPN10 antisense RNA 1 (head to head)	597	0.4
chr5_173960206_173960357	0.22	MSX2	msh homeobox 2	191255	0.03
chr2_105997925_105998220	0.22	AC012360.6		7522	0.19
chr5_14178416_14178612	0.22	TRIO	trio Rho guanine nucleotide exchange factor	5393	0.35
chr2_65605561_65605712	0.22	SPRED2	sprouty-related, EVH1 domain containing 2	752	0.66
chr2_65132087_65132267	0.22	ENSG00000244534	.	2095	0.28
chr12_70329549_70329700	0.22	MYRFL	myelin regulatory factor-like	3308	0.29
chr20_43150138_43150289	0.22	SERINC3	serine incorporator 3	438	0.78
chr2_102371116_102371522	0.22	MAP4K4	mitogen-activated protein kinase kinase kinase kinase 4	42407	0.2
chr10_3791986_3792257	0.22	RP11-184A2.3		1138	0.55
chr9_127058687_127058838	0.22	NEK6	NIMA-related kinase 6	3502	0.23
chr15_68996933_68997188	0.21	CORO2B	coronin, actin binding protein, 2B	72733	0.11
chr11_106353555_106353706	0.21	RP11-680E19.1		218588	0.02
chr1_193073520_193073675	0.21	GLRX2	glutaredoxin 2	964	0.46
chr8_81209498_81209699	0.21	ENSG00000206649	.	19706	0.21
chr4_183065081_183065265	0.21	AC108142.1		132	0.85
chr22_18345511_18345662	0.21	MICAL3	microtubule associated monooxygenase, calponin and LIM domain containing 3	30820	0.17
chr12_95597054_95597379	0.21	FGD6	FYVE, RhoGEF and PH domain containing 6	13939	0.18
chr5_157171669_157172078	0.21	LSM11	LSM11, U7 small nuclear RNA associated	1170	0.4
chr6_19838520_19838671	0.21	RP1-167F1.2		716	0.55
chr7_33894333_33894504	0.21	BMPER	BMP binding endothelial regulator	50105	0.18
chr7_45040547_45040957	0.21	CCM2	cerebral cavernous malformation 2	965	0.47
chr17_17642246_17642462	0.21	RAI1-AS1	RAI1 antisense RNA 1	31781	0.12
chr1_234754493_234754778	0.21	IRF2BP2	interferon regulatory factor 2 binding protein 2	9364	0.19
chr8_145655573_145655724	0.20	VPS28	vacuolar protein sorting 28 homolog (S. cerevisiae)	1717	0.13
chr1_44154355_44154570	0.20	KDM4A-AS1	KDM4A antisense RNA 1	15678	0.14
chr7_92255177_92255408	0.20	FAM133B	family with sequence similarity 133, member B	35584	0.17
chr6_69344527_69344720	0.20	RP3-525N10.2		231	0.82
chr2_149401069_149401839	0.20	EPC2	enhancer of polycomb homolog 2 (Drosophila)	555	0.86
chr12_96487410_96487841	0.20	ENSG00000266889	.	8402	0.2
chr1_78561687_78561966	0.19	ENSG00000202263	.	1227	0.46
chr1_55370512_55370663	0.19	RP11-67L3.4		17182	0.14
chr5_4197921_4198072	0.19	CTD-2012M11.3		597694	0.0
chr22_47201366_47201517	0.19	TBC1D22A	TBC1 domain family, member 22A	31617	0.16
chr2_62702609_62702952	0.19	ENSG00000241625	.	15533	0.23
chr22_33113641_33113825	0.19	LL22NC01-116C6.1		65430	0.11
chr20_43966692_43966843	0.19	SDC4	syndecan 4	10297	0.12
chr5_145297127_145297278	0.19	SH3RF2	SH3 domain containing ring finger 2	18940	0.22
chr1_108584195_108584461	0.19	ENSG00000264753	.	22935	0.22
chr5_58999641_58999792	0.19	ENSG00000202601	.	187	0.97
chr10_79339026_79339177	0.19	ENSG00000199592	.	7706	0.27
chr2_216973110_216973261	0.19	XRCC5	X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)	835	0.62
chr12_6960691_6960910	0.19	CDCA3	cell division cycle associated 3	367	0.48
chr8_102120279_102120548	0.19	ENSG00000202360	.	29774	0.2
chr2_217237352_217237503	0.19	MARCH4	membrane-associated ring finger (C3HC4) 4, E3 ubiquitin protein ligase	677	0.66
chr1_44266850_44267001	0.19	ST3GAL3	ST3 beta-galactoside alpha-2,3-sialyltransferase 3	64991	0.08
chr6_71817462_71817736	0.19	ENSG00000221345	.	19209	0.25
chr1_22463906_22464057	0.19	WNT4	wingless-type MMTV integration site family, member 4	5478	0.23
chr17_27419224_27419375	0.19	TIAF1	TGFB1-induced anti-apoptotic factor 1	762	0.58
chr6_158460041_158460192	0.18	SYNJ2	synaptojanin 2	21619	0.18
chr5_106907227_106907905	0.18	EFNA5	ephrin-A5	98762	0.09
chr5_137876739_137877439	0.18	ETF1	eukaryotic translation termination factor 1	311	0.86
chr7_66146609_66146762	0.18	RP4-756H11.3		27112	0.16
chr22_50732960_50733111	0.18	PLXNB2	plexin B2	5045	0.1
chr6_6814488_6814639	0.18	ENSG00000240936	.	124567	0.06
chr2_172654761_172655200	0.18	AC068039.4		24988	0.19
chr4_55779949_55780100	0.18	ENSG00000264332	.	97075	0.07
chr1_7462341_7462492	0.18	RP3-453P22.2		12602	0.21
chr1_10958636_10958867	0.18	C1orf127	chromosome 1 open reading frame 127	49176	0.12
chr11_128779050_128779201	0.18	KCNJ5	potassium inwardly-rectifying channel, subfamily J, member 5	1954	0.27
chr5_153569731_153569882	0.18	GALNT10	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 10 (GalNAc-T10)	484	0.86
chr1_201463290_201463773	0.18	CSRP1	cysteine and glycine-rich protein 1	2170	0.26
chr7_21982587_21982783	0.18	CDCA7L	cell division cycle associated 7-like	1806	0.5
chr3_132349120_132349271	0.18	UBA5	ubiquitin-like modifier activating enzyme 5	24095	0.16
chr7_2800167_2800318	0.18	GNA12	guanine nucleotide binding protein (G protein) alpha 12	2532	0.35
chr10_81024445_81024596	0.18	ZMIZ1	zinc finger, MIZ-type containing 1	41455	0.18
chr22_31884469_31885148	0.18	EIF4ENIF1	eukaryotic translation initiation factor 4E nuclear import factor 1	77	0.96
chr9_115534398_115534820	0.18	SNX30	sorting nexin family member 30	21491	0.18
chr2_118863719_118863870	0.18	INSIG2	insulin induced gene 2	17744	0.23
chr5_135347344_135347609	0.18	TGFBI	transforming growth factor, beta-induced, 68kDa	17108	0.2
chr22_43540224_43540381	0.18	MCAT	malonyl CoA:ACP acyltransferase (mitochondrial)	902	0.5
chr9_14183184_14183335	0.18	NFIB	nuclear factor I/B	2462	0.44
chr13_92002817_92003060	0.17	ENSG00000215417	.	59	0.99
chr7_32303689_32303840	0.17	PDE1C	phosphodiesterase 1C, calmodulin-dependent 70kDa	35177	0.24
chr16_11593490_11593706	0.17	CTD-3088G3.8	Protein LOC388210	7987	0.15
chr10_131129546_131129832	0.17	MGMT	O-6-methylguanine-DNA methyltransferase	135759	0.05
chr3_111400647_111400798	0.17	PLCXD2-AS1	PLCXD2 antisense RNA 1	4442	0.23
chr1_157565778_157565929	0.17	FCRL4	Fc receptor-like 4	2017	0.38
chr13_77568293_77568444	0.17	CLN5	ceroid-lipofuscinosis, neuronal 5	3573	0.23
chr13_60026420_60026571	0.17	ENSG00000239003	.	27709	0.27
chr5_14745440_14745591	0.17	ANKH	ANKH inorganic pyrophosphate transport regulator	5805	0.26
chr22_28107190_28107341	0.17	RP11-375H17.1		5203	0.32
chr4_6992668_6992852	0.17	TBC1D14	TBC1 domain family, member 14	3871	0.13
chr5_126111255_126111406	0.17	LMNB1	lamin B1	1510	0.46
chr2_68937791_68938087	0.17	ARHGAP25	Rho GTPase activating protein 25	305	0.93
chr1_207262289_207262674	0.17	C4BPB	complement component 4 binding protein, beta	77	0.96
chr15_59463059_59463212	0.17	ENSG00000253030	.	326	0.81
chr13_52748916_52749067	0.17	NEK3	NIMA-related kinase 3	14995	0.18
chr20_52421695_52421846	0.17	AC005220.3		134929	0.05
chr1_221932844_221932995	0.17	DUSP10	dual specificity phosphatase 10	17401	0.28
chr2_227050336_227050624	0.17	ENSG00000263363	.	473029	0.01
chr11_104941248_104941509	0.17	CARD16	caspase recruitment domain family, member 16	25275	0.15
chr17_26897925_26898076	0.17	PIGS	phosphatidylinositol glycan anchor biosynthesis, class S	546	0.49
chr1_27626340_27626505	0.17	TMEM222	transmembrane protein 222	22229	0.11
chr15_52069126_52069277	0.17	CTD-2308G16.1		24519	0.12
chr7_92253875_92254026	0.17	FAM133B	family with sequence similarity 133, member B	34242	0.17
chr9_74384006_74384157	0.17	TMEM2	transmembrane protein 2	281	0.95
chr12_90267768_90267973	0.17	ENSG00000252823	.	120034	0.06
chr5_40401420_40402168	0.17	ENSG00000265615	.	81374	0.11
chr2_38151916_38152120	0.17	RMDN2	regulator of microtubule dynamics 2	444	0.89
chr10_101686899_101687132	0.17	DNMBP-AS1	DNMBP antisense RNA 1	49	0.98
chr12_98812168_98812319	0.17	ENSG00000201296	.	427	0.88
chr8_21967356_21967589	0.17	NUDT18	nudix (nucleoside diphosphate linked moiety X)-type motif 18	540	0.64
chr14_69735167_69735318	0.17	GALNT16	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 16	8234	0.24
chr6_82854761_82854912	0.17	ENSG00000223044	.	65321	0.14
chr5_53510644_53510880	0.16	ARL15	ADP-ribosylation factor-like 15	95641	0.08
chr3_39276693_39276844	0.16	XIRP1	xin actin-binding repeat containing 1	42681	0.13
chr20_50312015_50312166	0.16	ATP9A	ATPase, class II, type 9A	72777	0.11
chr17_66179467_66179660	0.16	LRRC37A16P	leucine rich repeat containing 37, member A16, pseudogene	30954	0.15
chr14_78058344_78058495	0.16	SPTLC2	serine palmitoyltransferase, long chain base subunit 2	5245	0.21
chr5_96170923_96171074	0.16	ERAP1	endoplasmic reticulum aminopeptidase 1	27195	0.12
chr8_24153597_24153748	0.16	ADAM28	ADAM metallopeptidase domain 28	2048	0.42
chr21_16249905_16250056	0.16	AF127577.8		40875	0.18
chr6_7153073_7153464	0.16	RREB1	ras responsive element binding protein 1	13790	0.19
chr3_71111992_71112428	0.16	FOXP1	forkhead box P1	1867	0.51
chr1_192670704_192670864	0.16	RGS13	regulator of G-protein signaling 13	65502	0.12
chr9_95500415_95500727	0.16	BICD2	bicaudal D homolog 2 (Drosophila)	26523	0.17
chr4_74975080_74975254	0.16	CXCL2	chemokine (C-X-C motif) ligand 2	10157	0.16
chr1_43203800_43204078	0.16	CLDN19	claudin 19	1872	0.26
chr11_95770595_95770746	0.16	MTMR2	myotubularin related protein 2	113211	0.07
chr13_53419930_53420188	0.16	PCDH8	protocadherin 8	2581	0.35
chr2_39777891_39778042	0.16	AC007246.3		32150	0.21
chr17_76374368_76374519	0.16	PGS1	phosphatidylglycerophosphate synthase 1	278	0.87
chr3_48724801_48724952	0.16	NCKIPSD	NCK interacting protein with SH3 domain	1079	0.35
chr11_46936507_46936803	0.16	LRP4	low density lipoprotein receptor-related protein 4	3518	0.23
chr9_92445809_92446274	0.16	GADD45G	growth arrest and DNA-damage-inducible, gamma	226088	0.02
chr1_61606862_61607139	0.16	RP4-802A10.1		16595	0.23
chr8_144682971_144683122	0.16	EEF1D	eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)	1335	0.19
chr8_96902024_96902175	0.16	ENSG00000223297	.	210956	0.02
chr3_194838476_194838628	0.16	XXYLT1	xyloside xylosyltransferase 1	4369	0.17
chr12_124451409_124451560	0.16	RP11-214K3.21		308	0.71
chr7_104908892_104909338	0.16	SRPK2	SRSF protein kinase 2	347	0.9
chr17_39094006_39094157	0.16	KRT23	keratin 23 (histone deacetylase inducible)	343	0.76
chr6_110849182_110849360	0.16	CTA-331P3.1		50161	0.13
chr13_45816557_45816749	0.16	KCTD4	potassium channel tetramerization domain containing 4	41478	0.12
chr8_37468731_37468882	0.16	ENSG00000223215	.	57610	0.1
chr1_33829610_33829761	0.16	PHC2	polyhomeotic homolog 2 (Drosophila)	8875	0.14
chr8_9791123_9791323	0.16	ENSG00000238496	.	1890	0.37
chr2_113881955_113882155	0.15	IL1RN	interleukin 1 receptor antagonist	3083	0.19
chr7_139510118_139510269	0.15	TBXAS1	thromboxane A synthase 1 (platelet)	18759	0.22
chr16_70731287_70731500	0.15	VAC14	Vac14 homolog (S. cerevisiae)	1897	0.26
chr4_170180392_170180649	0.15	SH3RF1	SH3 domain containing ring finger 1	10588	0.27
chr8_32776162_32776330	0.15	ENSG00000212407	.	7130	0.33
chr3_45595189_45595741	0.15	ENSG00000251927	.	38282	0.14
chr2_57825828_57826109	0.15	ENSG00000212168	.	54298	0.18
chr4_157870050_157870201	0.15	PDGFC	platelet derived growth factor C	21930	0.21

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of PKNOX2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.1	GO:0002043	blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.0	0.2	GO:0043497	regulation of protein heterodimerization activity(GO:0043497)
0.0	0.1	GO:0001821	histamine secretion(GO:0001821)
0.0	0.3	GO:0006198	cAMP catabolic process(GO:0006198)
0.0	0.1	GO:0016080	synaptic vesicle targeting(GO:0016080)
0.0	0.1	GO:0061154	endothelial tube morphogenesis(GO:0061154)
0.0	0.1	GO:0032959	inositol trisphosphate biosynthetic process(GO:0032959)
0.0	0.1	GO:0032516	positive regulation of phosphoprotein phosphatase activity(GO:0032516)
0.0	0.1	GO:0031946	regulation of glucocorticoid biosynthetic process(GO:0031946)
0.0	0.1	GO:0015816	glycine transport(GO:0015816)
0.0	0.1	GO:0001574	ganglioside biosynthetic process(GO:0001574)
0.0	0.1	GO:0072010	renal filtration cell differentiation(GO:0061318) glomerular epithelium development(GO:0072010) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.0	0.1	GO:0048643	positive regulation of skeletal muscle tissue development(GO:0048643)
0.0	0.1	GO:0021535	cell migration in hindbrain(GO:0021535)
0.0	0.1	GO:0072698	protein localization to cytoskeleton(GO:0044380) protein localization to microtubule cytoskeleton(GO:0072698)
0.0	0.1	GO:0071816	protein insertion into ER membrane(GO:0045048) tail-anchored membrane protein insertion into ER membrane(GO:0071816)
0.0	0.1	GO:0046501	protoporphyrinogen IX metabolic process(GO:0046501)
0.0	0.2	GO:0007185	transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0	0.1	GO:0018094	protein polyglycylation(GO:0018094)
0.0	0.1	GO:0015015	heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0	0.1	GO:0021819	layer formation in cerebral cortex(GO:0021819)
0.0	0.1	GO:0030011	maintenance of cell polarity(GO:0030011)
0.0	0.2	GO:0016255	attachment of GPI anchor to protein(GO:0016255)
0.0	0.1	GO:0042532	negative regulation of tyrosine phosphorylation of STAT protein(GO:0042532)
0.0	0.1	GO:0006549	isoleucine metabolic process(GO:0006549)
0.0	0.1	GO:0060218	hematopoietic stem cell differentiation(GO:0060218)
0.0	0.1	GO:0034501	protein localization to kinetochore(GO:0034501)
0.0	0.2	GO:0032986	nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.0	0.1	GO:0048702	embryonic neurocranium morphogenesis(GO:0048702)
0.0	0.1	GO:0001554	luteolysis(GO:0001554)
0.0	0.1	GO:0071501	response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.0	0.1	GO:0002328	pro-B cell differentiation(GO:0002328)
0.0	0.1	GO:0019227	neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0	0.1	GO:0008215	spermine metabolic process(GO:0008215)
0.0	0.1	GO:0008054	negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation(GO:0008054)
0.0	0.1	GO:0001553	luteinization(GO:0001553)
0.0	0.1	GO:2000114	regulation of establishment of cell polarity(GO:2000114)
0.0	0.1	GO:0060390	regulation of SMAD protein import into nucleus(GO:0060390)
0.0	0.1	GO:0006477	protein sulfation(GO:0006477)
0.0	0.1	GO:0006449	regulation of translational termination(GO:0006449)
0.0	0.1	GO:0006432	phenylalanyl-tRNA aminoacylation(GO:0006432)
0.0	0.1	GO:0060433	bronchus development(GO:0060433)
0.0	0.1	GO:0060081	membrane hyperpolarization(GO:0060081)
0.0	0.1	GO:0070561	vitamin D receptor signaling pathway(GO:0070561)
0.0	0.1	GO:0043490	malate-aspartate shuttle(GO:0043490)
0.0	0.1	GO:0048625	myoblast fate commitment(GO:0048625)
0.0	0.1	GO:0007042	lysosomal lumen acidification(GO:0007042) regulation of lysosomal lumen pH(GO:0035751)
0.0	0.2	GO:0008045	motor neuron axon guidance(GO:0008045)
0.0	0.0	GO:0051834	evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.0	0.1	GO:0008049	male courtship behavior(GO:0008049)
0.0	0.1	GO:0001543	ovarian follicle rupture(GO:0001543)
0.0	0.0	GO:0046826	negative regulation of protein export from nucleus(GO:0046826)
0.0	0.1	GO:0001921	positive regulation of receptor recycling(GO:0001921)
0.0	0.1	GO:0006108	malate metabolic process(GO:0006108)
0.0	0.0	GO:0030948	negative regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030948)
0.0	0.1	GO:0030091	protein repair(GO:0030091)
0.0	0.1	GO:0006105	succinate metabolic process(GO:0006105)
0.0	0.0	GO:0022038	corpus callosum development(GO:0022038)
0.0	0.0	GO:0032071	regulation of endodeoxyribonuclease activity(GO:0032071)
0.0	0.0	GO:0015864	pyrimidine nucleoside transport(GO:0015864)
0.0	0.1	GO:0051775	response to redox state(GO:0051775)
0.0	0.0	GO:0007207	phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.0	0.1	GO:0010288	response to lead ion(GO:0010288)
0.0	0.0	GO:0035234	ectopic germ cell programmed cell death(GO:0035234)
0.0	0.1	GO:0022027	interkinetic nuclear migration(GO:0022027)
0.0	0.0	GO:1900116	sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.0	0.0	GO:0032927	positive regulation of activin receptor signaling pathway(GO:0032927)
0.0	0.1	GO:0042492	gamma-delta T cell differentiation(GO:0042492)
0.0	0.0	GO:0006667	sphinganine metabolic process(GO:0006667)
0.0	0.0	GO:0007619	courtship behavior(GO:0007619)
0.0	0.1	GO:0018206	peptidyl-methionine modification(GO:0018206)
0.0	0.1	GO:0030644	cellular chloride ion homeostasis(GO:0030644) chloride ion homeostasis(GO:0055064)
0.0	0.1	GO:0006398	mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.0	0.0	GO:0031034	skeletal muscle myosin thick filament assembly(GO:0030241) myosin filament assembly(GO:0031034) striated muscle myosin thick filament assembly(GO:0071688)
0.0	0.1	GO:0031274	pseudopodium assembly(GO:0031269) regulation of pseudopodium assembly(GO:0031272) positive regulation of pseudopodium assembly(GO:0031274)
0.0	0.1	GO:0048013	ephrin receptor signaling pathway(GO:0048013)
0.0	0.3	GO:0000188	inactivation of MAPK activity(GO:0000188)
0.0	0.0	GO:0006562	proline catabolic process(GO:0006562)
0.0	0.0	GO:0009448	gamma-aminobutyric acid metabolic process(GO:0009448)
0.0	0.1	GO:0046952	ketone body catabolic process(GO:0046952)
0.0	0.1	GO:0048712	negative regulation of astrocyte differentiation(GO:0048712)
0.0	0.1	GO:0016246	RNA interference(GO:0016246)
0.0	0.2	GO:0000731	DNA synthesis involved in DNA repair(GO:0000731)
0.0	0.0	GO:0019805	quinolinate biosynthetic process(GO:0019805)
0.0	0.1	GO:0006591	ornithine metabolic process(GO:0006591)
0.0	0.0	GO:0030505	inorganic diphosphate transport(GO:0030505)
0.0	0.0	GO:0033262	regulation of nuclear cell cycle DNA replication(GO:0033262)
0.0	0.1	GO:1902603	carnitine shuttle(GO:0006853) carnitine transmembrane transport(GO:1902603)
0.0	0.1	GO:0006491	N-glycan processing(GO:0006491)
0.0	0.0	GO:0035511	oxidative DNA demethylation(GO:0035511)
0.0	0.0	GO:0021831	embryonic olfactory bulb interneuron precursor migration(GO:0021831)
0.0	0.1	GO:0071277	cellular response to calcium ion(GO:0071277)
0.0	0.0	GO:0046426	negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0	0.0	GO:0035520	monoubiquitinated protein deubiquitination(GO:0035520)
0.0	0.1	GO:0060292	long term synaptic depression(GO:0060292)
0.0	0.1	GO:0071108	protein K48-linked deubiquitination(GO:0071108)
0.0	0.1	GO:0050435	beta-amyloid metabolic process(GO:0050435)
0.0	0.0	GO:0019441	tryptophan catabolic process to kynurenine(GO:0019441)
0.0	0.0	GO:0003181	atrioventricular valve development(GO:0003171) atrioventricular valve morphogenesis(GO:0003181)
0.0	0.0	GO:0032467	positive regulation of cytokinesis(GO:0032467)
0.0	0.1	GO:0006896	Golgi to endosome transport(GO:0006895) Golgi to vacuole transport(GO:0006896)
0.0	0.1	GO:0043923	positive regulation by host of viral transcription(GO:0043923)
0.0	0.0	GO:0051124	synaptic growth at neuromuscular junction(GO:0051124)
0.0	0.3	GO:0006829	zinc II ion transport(GO:0006829)
0.0	0.0	GO:0001661	conditioned taste aversion(GO:0001661)
0.0	0.0	GO:0002679	respiratory burst involved in defense response(GO:0002679)
0.0	0.0	GO:0006104	succinyl-CoA metabolic process(GO:0006104)
0.0	0.0	GO:0072385	minus-end-directed organelle transport along microtubule(GO:0072385)
0.0	0.0	GO:0002032	desensitization of G-protein coupled receptor protein signaling pathway by arrestin(GO:0002032)
0.0	0.1	GO:0034331	cell junction maintenance(GO:0034331) cell-cell junction maintenance(GO:0045217)
0.0	0.0	GO:0022030	cerebral cortex radial glia guided migration(GO:0021801) telencephalon glial cell migration(GO:0022030)
0.0	0.0	GO:0070874	negative regulation of glycogen metabolic process(GO:0070874)
0.0	0.0	GO:0051573	negative regulation of histone H3-K9 methylation(GO:0051573)
0.0	0.1	GO:0006734	NADH metabolic process(GO:0006734)
0.0	0.1	GO:0043302	positive regulation of mast cell activation involved in immune response(GO:0033008) positive regulation of leukocyte degranulation(GO:0043302) positive regulation of mast cell degranulation(GO:0043306)
0.0	0.0	GO:0006384	transcription initiation from RNA polymerase III promoter(GO:0006384)
0.0	0.1	GO:0018026	peptidyl-lysine monomethylation(GO:0018026)
0.0	0.0	GO:0070295	renal water absorption(GO:0070295)

Gene overrepresentation in cellular component category:

Total log-likelihood	Term	Description
0.2	GO:0042765	GPI-anchor transamidase complex(GO:0042765)
0.2	GO:0005719	nuclear euchromatin(GO:0005719)
0.1	GO:0072379	BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.2	GO:0005652	nuclear lamina(GO:0005652)
0.1	GO:0043259	laminin-10 complex(GO:0043259)
0.1	GO:0009331	glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.1	GO:0071204	histone pre-mRNA 3'end processing complex(GO:0071204)
0.1	GO:0017059	palmitoyltransferase complex(GO:0002178) serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.1	GO:0005588	collagen type V trimer(GO:0005588)
0.1	GO:0042599	lamellar body(GO:0042599)
0.0	GO:0045323	interleukin-1 receptor complex(GO:0045323)
0.0	GO:0001940	male pronucleus(GO:0001940)
0.1	GO:0031430	M band(GO:0031430)
0.0	GO:0070188	obsolete Stn1-Ten1 complex(GO:0070188)
0.1	GO:0035253	ciliary rootlet(GO:0035253)
0.1	GO:0000782	telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783)
0.2	GO:0071564	npBAF complex(GO:0071564)
0.0	GO:0002139	stereocilia coupling link(GO:0002139) stereocilia ankle link(GO:0002141) stereocilia ankle link complex(GO:0002142)
0.1	GO:0061202	clathrin-sculpted gamma-aminobutyric acid transport vesicle(GO:0061200) clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane(GO:0061202)
0.4	GO:0005626	obsolete insoluble fraction(GO:0005626)
0.0	GO:0000791	euchromatin(GO:0000791)
0.0	GO:0031265	CD95 death-inducing signaling complex(GO:0031265)
0.1	GO:0034451	centriolar satellite(GO:0034451)
0.1	GO:0005678	obsolete chromatin assembly complex(GO:0005678)
0.2	GO:0080008	Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0	GO:0043240	Fanconi anaemia nuclear complex(GO:0043240)
0.0	GO:0005850	eukaryotic translation initiation factor 2 complex(GO:0005850)
0.1	GO:0005675	holo TFIIH complex(GO:0005675)
0.0	GO:0071664	catenin-TCF7L2 complex(GO:0071664)
0.1	GO:0005663	DNA replication factor C complex(GO:0005663)
0.0	GO:0043625	delta DNA polymerase complex(GO:0043625)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0030297	transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.1	0.2	GO:0005173	stem cell factor receptor binding(GO:0005173)
0.1	0.2	GO:0016149	translation release factor activity, codon specific(GO:0016149)
0.0	0.1	GO:0015038	glutathione disulfide oxidoreductase activity(GO:0015038)
0.0	0.1	GO:0004117	calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117)
0.0	0.1	GO:0004470	malic enzyme activity(GO:0004470)
0.0	0.2	GO:0003923	GPI-anchor transamidase activity(GO:0003923)
0.0	0.2	GO:0019211	phosphatase activator activity(GO:0019211)
0.0	0.1	GO:0004351	glutamate decarboxylase activity(GO:0004351)
0.0	0.1	GO:0033743	peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.0	0.1	GO:0070735	protein-glycine ligase activity(GO:0070735)
0.0	0.1	GO:0003691	double-stranded telomeric DNA binding(GO:0003691)
0.0	0.1	GO:0050998	nitric-oxide synthase binding(GO:0050998)
0.0	0.1	GO:0005042	netrin receptor activity(GO:0005042)
0.0	0.1	GO:0016647	oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.0	0.2	GO:0017169	CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.0	0.1	GO:0034187	obsolete apolipoprotein E binding(GO:0034187)
0.0	0.3	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0	0.1	GO:0098847	single-stranded telomeric DNA binding(GO:0043047) sequence-specific single stranded DNA binding(GO:0098847)
0.0	0.0	GO:0045545	syndecan binding(GO:0045545)
0.0	0.1	GO:0015467	G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0	0.1	GO:0004367	glycerol-3-phosphate dehydrogenase [NAD+] activity(GO:0004367)
0.0	0.1	GO:0000247	C-8 sterol isomerase activity(GO:0000247)
0.0	0.1	GO:0004982	N-formyl peptide receptor activity(GO:0004982)
0.0	0.1	GO:0009374	biotin binding(GO:0009374)
0.0	0.1	GO:0042978	ornithine decarboxylase activator activity(GO:0042978)
0.0	0.2	GO:0030332	cyclin binding(GO:0030332)
0.0	0.1	GO:0017154	semaphorin receptor activity(GO:0017154)
0.0	0.1	GO:0005152	interleukin-1 receptor antagonist activity(GO:0005152)
0.0	0.1	GO:0004597	peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.0	0.1	GO:0015183	L-aspartate transmembrane transporter activity(GO:0015183)
0.0	0.1	GO:0004301	epoxide hydrolase activity(GO:0004301)
0.0	0.1	GO:0016174	NAD(P)H oxidase activity(GO:0016174)
0.0	0.1	GO:0005017	platelet-derived growth factor-activated receptor activity(GO:0005017)
0.0	0.1	GO:0015016	[heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0	0.0	GO:0034056	estrogen response element binding(GO:0034056)
0.0	0.1	GO:0000900	translation repressor activity, nucleic acid binding(GO:0000900)
0.0	0.1	GO:0004826	phenylalanine-tRNA ligase activity(GO:0004826)
0.0	0.0	GO:0019797	procollagen-proline 3-dioxygenase activity(GO:0019797) peptidyl-proline 3-dioxygenase activity(GO:0031544)
0.0	0.0	GO:0004477	methenyltetrahydrofolate cyclohydrolase activity(GO:0004477)
0.0	0.0	GO:0051371	muscle alpha-actinin binding(GO:0051371)
0.0	0.0	GO:0001159	RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.0	0.1	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0	0.1	GO:0008242	omega peptidase activity(GO:0008242)
0.0	0.1	GO:0070053	thrombospondin receptor activity(GO:0070053)
0.0	0.2	GO:0008353	RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.0	0.1	GO:0050780	dopamine receptor binding(GO:0050780)
0.0	0.0	GO:0016454	serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0	0.1	GO:0016417	S-acyltransferase activity(GO:0016417)
0.0	0.1	GO:0016723	oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor(GO:0016723)
0.0	0.0	GO:0003987	acetate-CoA ligase activity(GO:0003987)
0.0	0.1	GO:0032266	phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0	0.1	GO:0008157	protein phosphatase 1 binding(GO:0008157)
0.0	0.1	GO:0031685	adenosine receptor binding(GO:0031685)
0.0	0.2	GO:0004653	polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0	0.1	GO:0015651	quaternary ammonium group transmembrane transporter activity(GO:0015651)
0.0	0.1	GO:0016361	activin receptor activity, type I(GO:0016361)
0.0	0.0	GO:0043734	DNA demethylase activity(GO:0035514) DNA-N1-methyladenine dioxygenase activity(GO:0043734)
0.0	0.0	GO:0008474	palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0	0.1	GO:0051920	peroxiredoxin activity(GO:0051920)
0.0	0.0	GO:0017060	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity(GO:0017060)
0.0	0.0	GO:0070324	thyroid hormone binding(GO:0070324)
0.0	0.0	GO:0008321	Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0	0.0	GO:0050508	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.0	0.1	GO:0050656	3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
0.0	0.0	GO:0004340	glucokinase activity(GO:0004340)
0.0	0.0	GO:0030235	nitric-oxide synthase regulator activity(GO:0030235)
0.0	0.0	GO:0047499	calcium-independent phospholipase A2 activity(GO:0047499)
0.0	0.1	GO:0070628	proteasome binding(GO:0070628)
0.0	0.1	GO:0046875	ephrin receptor binding(GO:0046875)
0.0	0.2	GO:0033549	MAP kinase phosphatase activity(GO:0033549)
0.0	0.1	GO:0005078	MAP-kinase scaffold activity(GO:0005078)
0.0	0.0	GO:0043398	HLH domain binding(GO:0043398)
0.0	0.1	GO:0033170	DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0	0.1	GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0	0.1	GO:0019894	kinesin binding(GO:0019894)
0.0	0.0	GO:0015272	ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.0	0.1	GO:0005536	glucose binding(GO:0005536)
0.0	0.1	GO:0016406	carnitine O-acyltransferase activity(GO:0016406)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.4	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.0	PID MET PATHWAY	Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.1	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.3	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
0.2	PID ARF6 DOWNSTREAM PATHWAY	Arf6 downstream pathway
0.0	SA CASPASE CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.3	PID ALK1 PATHWAY	ALK1 signaling events
0.1	PID S1P S1P4 PATHWAY	S1P4 pathway
0.4	PID HNF3A PATHWAY	FOXA1 transcription factor network
0.1	PID NETRIN PATHWAY	Netrin-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.3	REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING	Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.3	REACTOME ZINC TRANSPORTERS	Genes involved in Zinc transporters
0.2	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.3	REACTOME ENOS ACTIVATION AND REGULATION	Genes involved in eNOS activation and regulation
0.2	REACTOME OTHER SEMAPHORIN INTERACTIONS	Genes involved in Other semaphorin interactions
0.2	REACTOME SIGNALING BY NOTCH4	Genes involved in Signaling by NOTCH4
0.1	REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES	Genes involved in Recruitment of NuMA to mitotic centrosomes
0.3	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.1	REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS	Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.2	REACTOME DESTABILIZATION OF MRNA BY KSRP	Genes involved in Destabilization of mRNA by KSRP
0.2	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade
0.1	REACTOME PLATELET SENSITIZATION BY LDL	Genes involved in Platelet sensitization by LDL
0.1	REACTOME ERKS ARE INACTIVATED	Genes involved in ERKs are inactivated
0.1	REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION	Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation