Project
ENCODE: H3K4me1 ChIP-Seq of primary human cells
Navigation
Downloads
Results for POU1F1
Z-value: 1.69
Motif logo
Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:
This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.
For each TF, only the top 5 correlated CREs are shown.
| CRE | Gene | Distance | Association probability | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|---|---|
| chr3_87336126_87336277 | POU1F1 | 10464 | 0.257046 | -0.61 | 8.0e-02 | Click! |
| chr3_87347448_87347599 | POU1F1 | 21786 | 0.237651 | 0.85 | 3.6e-03 | Click! |
| chr3_87446861_87447012 | POU1F1 | 121199 | 0.061340 | -0.63 | 7.0e-02 | Click! |
| chr3_87447733_87447884 | POU1F1 | 122071 | 0.060671 | -0.64 | 6.6e-02 | Click! |
| chr3_87486002_87486153 | POU1F1 | 160340 | 0.038960 | -0.65 | 5.6e-02 | Click! |
Showing 1 to 5 of 5 entries
Top target CREs of the motif:
| Cis Regulatory Element (CRE) | Target Score | Top associated gene | Gene Info | Distance of CRE to TSS | CRE/Gene association probability |
|---|---|---|---|---|---|
| chr6_154561193_154561344 | 0.82 |
IPCEF1 |
interaction protein for cytohesin exchange factors 1 |
6722 |
0.33 |
| chr17_14101706_14102107 | 0.79 |
AC005224.2 |
|
11899 |
0.2 |
| chr2_32036582_32036828 | 0.68 |
ENSG00000238448 |
. |
1348 |
0.49 |
| chr6_2893026_2893177 | 0.68 |
SERPINB9 |
serpin peptidase inhibitor, clade B (ovalbumin), member 9 |
10413 |
0.18 |
| chrX_54435736_54436012 | 0.62 |
TSR2 |
TSR2, 20S rRNA accumulation, homolog (S. cerevisiae) |
30960 |
0.17 |
| chr17_47825562_47826034 | 0.61 |
FAM117A |
family with sequence similarity 117, member A |
15695 |
0.14 |
| chr5_56129477_56129628 | 0.61 |
MAP3K1 |
mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase |
18151 |
0.15 |
| chr2_106545238_106545692 | 0.59 |
AC009505.2 |
|
71832 |
0.11 |
| chr14_61800103_61800254 | 0.59 |
PRKCH |
protein kinase C, eta |
6547 |
0.21 |
| chr9_37302020_37302197 | 0.57 |
ENSG00000216070 |
. |
6007 |
0.22 |
Histogram of CRE-TSS distances for CREs targeted by :
Rank distribution of CRE target scores:
Distribution of target CREs across different genomic regions:
Network of associatons between targets according to the STRING database.
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.9 | GO:0006412 | translation(GO:0006412) |
| 0.1 | 3.5 | GO:0050852 | T cell receptor signaling pathway(GO:0050852) |
| 0.0 | 3.3 | GO:0000375 | RNA splicing, via transesterification reactions(GO:0000375) |
| 0.0 | 3.0 | GO:0018279 | peptidyl-asparagine modification(GO:0018196) protein N-linked glycosylation via asparagine(GO:0018279) |
| 0.0 | 2.6 | GO:0006397 | mRNA processing(GO:0006397) |
| 0.1 | 2.5 | GO:0050690 | regulation of defense response to virus by virus(GO:0050690) |
| 0.0 | 1.7 | GO:0022904 | respiratory electron transport chain(GO:0022904) |
| 0.2 | 1.6 | GO:0006491 | N-glycan processing(GO:0006491) |
| 0.1 | 1.5 | GO:0000289 | nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289) |
| 0.0 | 1.4 | GO:0071158 | positive regulation of cell cycle arrest(GO:0071158) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 18.2 | GO:0005829 | cytosol(GO:0005829) |
| 0.0 | 6.9 | GO:0005654 | nucleoplasm(GO:0005654) |
| 0.0 | 3.8 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.0 | 2.4 | GO:0000785 | chromatin(GO:0000785) |
| 0.0 | 2.1 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.0 | 2.0 | GO:0005625 | obsolete soluble fraction(GO:0005625) |
| 0.2 | 1.9 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.0 | 1.9 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.0 | 1.7 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 0.0 | 1.6 | GO:0005626 | obsolete insoluble fraction(GO:0005626) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 7.8 | GO:0003723 | RNA binding(GO:0003723) |
| 0.0 | 3.9 | GO:0019787 | ubiquitin-like protein transferase activity(GO:0019787) |
| 0.0 | 3.1 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.1 | 3.0 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 0.2 | 2.8 | GO:0004697 | protein kinase C activity(GO:0004697) |
| 0.0 | 2.8 | GO:0005525 | GTP binding(GO:0005525) |
| 0.0 | 2.5 | GO:0016563 | obsolete transcription activator activity(GO:0016563) |
| 0.0 | 2.4 | GO:0008301 | DNA binding, bending(GO:0008301) |
| 0.1 | 2.2 | GO:0001608 | G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028) |
| 0.1 | 1.9 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.1 | PID CD8 TCR PATHWAY | TCR signaling in naïve CD8+ T cells |
| 0.1 | 4.7 | PID NFAT 3PATHWAY | Role of Calcineurin-dependent NFAT signaling in lymphocytes |
| 0.1 | 2.7 | PID IL2 STAT5 PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.1 | 2.7 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.1 | 2.2 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.1 | 1.6 | PID IL8 CXCR2 PATHWAY | IL8- and CXCR2-mediated signaling events |
| 0.1 | 1.5 | SA PTEN PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
| 0.1 | 1.5 | ST PHOSPHOINOSITIDE 3 KINASE PATHWAY | PI3K Pathway |
| 0.0 | 1.4 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.1 | 1.3 | PID TNF PATHWAY | TNF receptor signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.1 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 0.0 | 2.9 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.1 | 2.7 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.1 | 2.6 | REACTOME NOD1 2 SIGNALING PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
| 0.0 | 2.4 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.2 | 2.3 | REACTOME N GLYCAN ANTENNAE ELONGATION | Genes involved in N-Glycan antennae elongation |
| 0.1 | 2.1 | REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS | Genes involved in Phosphorylation of CD3 and TCR zeta chains |
| 0.1 | 2.1 | REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.2 | 1.9 | REACTOME GENERATION OF SECOND MESSENGER MOLECULES | Genes involved in Generation of second messenger molecules |
| 0.1 | 1.9 | REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |