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ENCODE: H3K4me1 ChIP-Seq of primary human cells

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Results for POU3F3_POU3F4

Z-value: 1.37

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Transcription factors associated with POU3F3_POU3F4

Gene Symbol	Gene ID	Gene Info
POU3F3 Ensembl NCBI GeneCards UniProt	ENSG00000198914.2	POU class 3 homeobox 3
POU3F4 Ensembl NCBI GeneCards UniProt	ENSG00000196767.4	POU class 3 homeobox 4

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
chr2_105473669_105474121	POU3F3	1926	0.238342	0.38	3.2e-01	Click!
chr2_105471047_105471286	POU3F3	803	0.422355	0.33	3.8e-01	Click!
chr2_105472844_105473231	POU3F3	1068	0.399217	0.31	4.1e-01	Click!
chr2_105471539_105471690	POU3F3	355	0.778224	-0.16	6.8e-01	Click!
chr2_105470837_105471020	POU3F3	1041	0.291801	0.10	8.0e-01	Click!
chrX_82763241_82763392	POU3F4	47	0.956198	-0.26	5.0e-01	Click!

Activity of the POU3F3_POU3F4 motif across conditions

Conditions sorted by the z-value of the POU3F3_POU3F4 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr1_154357957_154358230	0.55	IL6R	interleukin 6 receptor	19576	0.11
chr11_45794103_45794254	0.42	CTD-2210P24.4	Uncharacterized protein	1195	0.45
chr1_186345379_186345747	0.38	C1orf27	chromosome 1 open reading frame 27	562	0.5
chr8_101315735_101315886	0.38	RNF19A	ring finger protein 19A, RBR E3 ubiquitin protein ligase	323	0.91
chr12_9921460_9921827	0.38	CD69	CD69 molecule	8146	0.16
chr3_32502297_32502460	0.33	CMTM6	CKLF-like MARVEL transmembrane domain containing 6	42522	0.15
chr13_46750553_46750948	0.32	LCP1	lymphocyte cytosolic protein 1 (L-plastin)	5709	0.17
chrX_47052555_47052957	0.32	UBA1	ubiquitin-like modifier activating enzyme 1	472	0.73
chr1_114322751_114323179	0.29	PHTF1	putative homeodomain transcription factor 1	20867	0.15
chr3_10267097_10267330	0.29	ENSG00000222348	.	8317	0.13
chr10_102271336_102271663	0.29	SEC31B	SEC31 homolog B (S. cerevisiae)	8092	0.16
chr15_37050639_37050790	0.29	C15orf41	chromosome 15 open reading frame 41	2568	0.4
chr10_14566731_14566882	0.29	FAM107B	family with sequence similarity 107, member B	7903	0.25
chr3_121373270_121373519	0.28	ENSG00000243544	.	251	0.84
chr11_102175591_102175819	0.28	ENSG00000212466	.	8748	0.18
chr8_19553650_19553834	0.28	CSGALNACT1	chondroitin sulfate N-acetylgalactosaminyltransferase 1	13470	0.29
chr19_6814065_6814233	0.28	VAV1	vav 1 guanine nucleotide exchange factor	30020	0.12
chr4_148704497_148704648	0.27	ENSG00000264274	.	826	0.63
chr7_21396277_21396723	0.27	ENSG00000195024	.	24481	0.21
chrX_44105690_44105874	0.27	EFHC2	EF-hand domain (C-terminal) containing 2	97136	0.08
chr1_167297912_167298063	0.27	POU2F1	POU class 2 homeobox 1	294	0.93
chr12_105082245_105082396	0.26	ENSG00000264295	.	96909	0.07
chr2_235072563_235072714	0.26	SPP2	secreted phosphoprotein 2, 24kDa	113207	0.07
chr7_48130773_48130924	0.26	UPP1	uridine phosphorylase 1	1875	0.39
chr3_153009226_153009454	0.26	ENSG00000265813	.	91534	0.09
chr5_40406098_40406422	0.25	ENSG00000265615	.	85840	0.1
chr14_65177392_65177647	0.25	PLEKHG3	pleckstrin homology domain containing, family G (with RhoGef domain) member 3	4902	0.25
chr2_202059112_202059539	0.25	CASP10	caspase 10, apoptosis-related cysteine peptidase	11407	0.15
chr6_159519338_159519692	0.25	TAGAP	T-cell activation RhoGTPase activating protein	53331	0.11
chr4_153563986_153564137	0.25	RP11-768B22.2		23459	0.19
chr11_39393038_39393279	0.25	ENSG00000201591	.	110501	0.08
chr1_229170121_229170313	0.25	RP5-1061H20.5		193092	0.02
chr5_118654433_118654664	0.25	ENSG00000243333	.	12222	0.19
chr15_81578352_81578503	0.25	IL16	interleukin 16	10827	0.21
chr2_197046968_197047186	0.25	STK17B	serine/threonine kinase 17b	5850	0.21
chr14_35770855_35771036	0.25	PSMA6	proteasome (prosome, macropain) subunit, alpha type, 6	9094	0.22
chr2_101925778_101926057	0.25	ENSG00000264857	.	5	0.94
chr6_24857746_24858061	0.24	ENSG00000263391	.	17610	0.17
chr2_99386231_99386655	0.24	ENSG00000201070	.	12430	0.21
chr2_68968807_68969362	0.24	ARHGAP25	Rho GTPase activating protein 25	7070	0.26
chr14_91879240_91879633	0.24	CCDC88C	coiled-coil domain containing 88C	4254	0.28
chr18_59865808_59865959	0.24	KIAA1468	KIAA1468	11359	0.19
chr14_71463175_71463326	0.24	PCNX	pecanex homolog (Drosophila)	16498	0.28
chr22_40322306_40322457	0.24	GRAP2	GRB2-related adaptor protein 2	214	0.93
chr6_24937638_24937929	0.23	FAM65B	family with sequence similarity 65, member B	1595	0.45
chr4_40211382_40211567	0.23	RHOH	ras homolog family member H	9510	0.22
chr20_18269547_18269794	0.23	ZNF133	zinc finger protein 133	492	0.7
chr6_35591091_35591242	0.23	ENSG00000212579	.	28429	0.14
chr15_93445391_93445689	0.23	CHD2	chromodomain helicase DNA binding protein 2	1975	0.29
chr11_118109730_118110277	0.23	MPZL3	myelin protein zero-like 3	13059	0.13
chr5_58549558_58549709	0.23	PDE4D	phosphodiesterase 4D, cAMP-specific	22312	0.28
chr9_126865106_126865257	0.23	RP11-85O21.5		70378	0.09
chr2_213967890_213968041	0.22	IKZF2	IKAROS family zinc finger 2 (Helios)	45388	0.18
chr13_52173909_52174060	0.22	ENSG00000242893	.	5633	0.15
chr9_114660957_114661108	0.22	UGCG	UDP-glucose ceramide glucosyltransferase	1986	0.34
chr10_6607286_6607516	0.22	PRKCQ	protein kinase C, theta	14800	0.3
chr9_92081899_92082135	0.22	SEMA4D	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D	11149	0.23
chr8_29987968_29988119	0.22	MBOAT4	membrane bound O-acyltransferase domain containing 4	14159	0.14
chr2_136849726_136849877	0.22	CXCR4	chemokine (C-X-C motif) receptor 4	24012	0.23
chr11_104668978_104669231	0.22	CASP12	caspase 12 (gene/pseudogene)	100037	0.07
chr3_71502428_71502579	0.22	ENSG00000221264	.	88737	0.09
chr2_99351569_99351826	0.22	MGAT4A	mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A	4108	0.27
chr22_40477750_40477901	0.22	TNRC6B	trinucleotide repeat containing 6B	36347	0.15
chr3_121990121_121990409	0.22	ENSG00000221474	.	10435	0.16
chr4_36388271_36388560	0.22	RP11-431M7.2		5617	0.32
chr10_14600389_14600584	0.22	FAM107B	family with sequence similarity 107, member B	2307	0.38
chr3_45010165_45010401	0.22	ZDHHC3	zinc finger, DHHC-type containing 3	7375	0.16
chr5_156644932_156645196	0.22	CTB-4E7.1		6326	0.14
chr5_50056624_50056775	0.22	PARP8	poly (ADP-ribose) polymerase family, member 8	93308	0.1
chr2_182170035_182170282	0.22	ENSG00000266705	.	221	0.97
chr12_64992216_64992511	0.21	RP11-338E21.1		10876	0.13
chr11_109897140_109897291	0.21	ZC3H12C	zinc finger CCCH-type containing 12C	66872	0.15
chr4_78727930_78728100	0.21	CNOT6L	CCR4-NOT transcription complex, subunit 6-like	12202	0.26
chr10_116259650_116260051	0.21	ABLIM1	actin binding LIM protein 1	12098	0.26
chr12_116655597_116655748	0.21	RP11-115H15.2		36572	0.15
chr12_57874491_57874847	0.21	ARHGAP9	Rho GTPase activating protein 9	1020	0.29
chr14_25075631_25076051	0.21	GZMH	granzyme H (cathepsin G-like 2, protein h-CCPX)	3023	0.2
chr19_34758530_34758681	0.21	KIAA0355	KIAA0355	13103	0.21
chr10_22978561_22978797	0.21	PIP4K2A	phosphatidylinositol-5-phosphate 4-kinase, type II, alpha	24358	0.25
chr5_88179576_88179735	0.21	MEF2C	myocyte enhancer factor 2C	353	0.55
chr1_169571123_169571274	0.21	F5	coagulation factor V (proaccelerin, labile factor)	15372	0.19
chr2_69001095_69001287	0.21	ARHGAP25	Rho GTPase activating protein 25	742	0.73
chr2_106709974_106710125	0.21	C2orf40	chromosome 2 open reading frame 40	27793	0.2
chr12_10282940_10283100	0.21	CLEC7A	C-type lectin domain family 7, member A	164	0.93
chr3_38174906_38175057	0.21	ACAA1	acetyl-CoA acyltransferase 1	1544	0.31
chr7_13951120_13951467	0.21	ETV1	ets variant 1	74773	0.12
chr16_22028470_22028691	0.21	C16orf52	chromosome 16 open reading frame 52	8976	0.17
chr6_130231106_130231257	0.21	TMEM244	transmembrane protein 244	48489	0.17
chr1_158616033_158616184	0.21	OR10Z1	olfactory receptor, family 10, subfamily Z, member 1	39879	0.1
chr18_22045790_22045941	0.21	HRH4	histamine receptor H4	5172	0.18
chr11_60214353_60214504	0.20	MS4A1	membrane-spanning 4-domains, subfamily A, member 1	8797	0.16
chr17_33168253_33168556	0.20	CCT6B	chaperonin containing TCP1, subunit 6B (zeta 2)	120017	0.05
chr13_52107424_52107667	0.20	INTS6-AS1	INTS6 antisense RNA 1	8149	0.14
chr16_53409275_53409426	0.20	RP11-44F14.1		2355	0.27
chr10_90590706_90591168	0.20	ANKRD22	ankyrin repeat domain 22	20638	0.15
chr2_106545238_106545692	0.20	AC009505.2		71832	0.11
chr2_198111909_198112068	0.20	ANKRD44	ankyrin repeat domain 44	49226	0.11
chr2_231323239_231323510	0.20	SP100	SP100 nuclear antigen	3776	0.28
chr1_192774854_192775005	0.20	RGS2	regulator of G-protein signaling 2, 24kDa	3242	0.34
chr6_143111835_143111986	0.20	RP1-67K17.3		42330	0.17
chr2_101918471_101918638	0.20	RNF149	ring finger protein 149	6604	0.17
chr1_207508809_207508960	0.20	CD55	CD55 molecule, decay accelerating factor for complement (Cromer blood group)	13748	0.26
chr2_158977463_158977689	0.20	UPP2-IT1	UPP2 intronic transcript 1 (non-protein coding)	6893	0.22
chr20_47439085_47439236	0.20	PREX1	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1	5260	0.3
chr2_62435329_62435921	0.20	ENSG00000266097	.	2664	0.25
chr12_12480582_12480816	0.20	MANSC1	MANSC domain containing 1	10909	0.16
chr12_21792716_21792887	0.20	LDHB	lactate dehydrogenase B	17495	0.17
chr1_156933706_156934136	0.20	ARHGEF11	Rho guanine nucleotide exchange factor (GEF) 11	15115	0.14
chr1_167617183_167617334	0.20	RP3-455J7.4		17347	0.18
chr20_44615863_44616021	0.20	ZNF335	zinc finger protein 335	15109	0.11
chr1_198621424_198621575	0.20	PTPRC	protein tyrosine phosphatase, receptor type, C	13207	0.23
chr5_130707612_130707916	0.20	CDC42SE2	CDC42 small effector 2	13535	0.29
chr2_42482692_42482843	0.20	EML4	echinoderm microtubule associated protein like 4	45626	0.16
chr1_200121942_200122869	0.20	ENSG00000221403	.	8443	0.27
chr6_147092750_147093047	0.20	ADGB	androglobin	1183	0.62
chr17_56232012_56232163	0.20	OR4D1	olfactory receptor, family 4, subfamily D, member 1	407	0.8
chr14_53207062_53207343	0.20	STYX	serine/threonine/tyrosine interacting protein	10302	0.15
chr13_48760783_48760934	0.19	ITM2B	integral membrane protein 2B	46436	0.16
chr8_129288456_129288700	0.19	ENSG00000201782	.	55828	0.16
chr2_103303794_103303953	0.19	MFSD9	major facilitator superfamily domain containing 9	49440	0.14
chr12_116652806_116653048	0.19	RP11-115H15.2		33827	0.16
chr5_140989194_140989552	0.19	AC008781.7		8608	0.11
chr2_198009213_198009725	0.19	ANKRD44	ankyrin repeat domain 44	3159	0.32
chr5_102100603_102100850	0.19	PAM	peptidylglycine alpha-amidating monooxygenase	9679	0.32
chr2_175441498_175441649	0.19	AC010894.5		1618	0.33
chr5_10963130_10963281	0.19	ENSG00000207312	.	64107	0.14
chr3_114416197_114416461	0.19	ENSG00000264623	.	46043	0.18
chr10_1088979_1089298	0.19	ENSG00000238924	.	843	0.49
chr2_113894435_113894586	0.19	IL1RN	interleukin 1 receptor antagonist	9372	0.14
chr1_231112420_231112571	0.19	TTC13	tetratricopeptide repeat domain 13	2047	0.22
chr5_130596712_130596930	0.19	CDC42SE2	CDC42 small effector 2	2881	0.38
chr20_44833333_44833580	0.19	CDH22	cadherin 22, type 2	46878	0.14
chr2_120968332_120968483	0.19	AC012363.4		5713	0.18
chr3_128436686_128436837	0.19	ENSG00000207130	.	3213	0.23
chr2_197070127_197070278	0.19	ENSG00000239161	.	9844	0.19
chr3_69485183_69485473	0.19	FRMD4B	FERM domain containing 4B	49898	0.18
chr5_56119363_56119514	0.19	MAP3K1	mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase	8037	0.19
chr14_22341717_22342288	0.19	ENSG00000222776	.	93217	0.08
chr13_42648927_42649078	0.19	DGKH	diacylglycerol kinase, eta	26113	0.19
chr21_40581692_40581843	0.19	BRWD1-IT1	BRWD1 intronic transcript 1 (non-protein coding)	9964	0.16
chr2_219974541_219974781	0.19	ENSG00000240317	.	7505	0.11
chr17_45747099_45747521	0.19	KPNB1	karyopherin (importin) beta 1	1579	0.29
chr9_37146709_37147098	0.19	ENSG00000200502	.	13231	0.18
chr14_38548380_38548531	0.19	CTD-2058B24.2		11908	0.26
chr5_157270322_157270473	0.19	CLINT1	clathrin interactor 1	15744	0.2
chr9_237929_238429	0.19	C9orf66	chromosome 9 open reading frame 66	22286	0.16
chr2_143827754_143827905	0.19	ARHGAP15	Rho GTPase activating protein 15	21102	0.24
chr9_88952239_88952471	0.19	ZCCHC6	zinc finger, CCHC domain containing 6	5683	0.25
chr15_60988910_60989061	0.19	RP11-219B17.2		15159	0.21
chr13_97875305_97875640	0.19	MBNL2	muscleblind-like splicing regulator 2	863	0.74
chr1_153318262_153318436	0.19	PGLYRP4	peptidoglycan recognition protein 4	2673	0.16
chr3_177723370_177723548	0.19	ENSG00000199858	.	2108	0.49
chr10_26779118_26779269	0.19	ENSG00000199733	.	19325	0.24
chr3_171039349_171039500	0.19	TNIK	TRAF2 and NCK interacting kinase	95924	0.08
chr1_184128074_184128225	0.19	ENSG00000199840	.	12808	0.26
chr5_100231344_100231575	0.18	ST8SIA4	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4	7459	0.31
chr14_90209657_90209808	0.18	ENSG00000200312	.	30877	0.19
chr1_167602468_167602965	0.18	RP3-455J7.4		2805	0.25
chr3_141218689_141219075	0.18	RASA2	RAS p21 protein activator 2	12991	0.21
chr13_108923662_108923813	0.18	TNFSF13B	tumor necrosis factor (ligand) superfamily, member 13b	1493	0.44
chr6_137710654_137710959	0.18	OLIG3	oligodendrocyte transcription factor 3	104725	0.07
chr10_4013290_4013441	0.18	KLF6	Kruppel-like factor 6	185892	0.03
chr10_60120674_60120825	0.18	TFAM	transcription factor A, mitochondrial	24033	0.19
chr2_152494355_152494506	0.18	NEB	nebulin	54297	0.17
chr2_81698214_81698365	0.18	ENSG00000200890	.	25162	0.28
chr12_15116052_15116331	0.18	ARHGDIB	Rho GDP dissociation inhibitor (GDI) beta	1529	0.36
chr2_197069816_197069967	0.18	ENSG00000239161	.	10155	0.19
chr2_37782808_37783015	0.18	AC006369.2		44368	0.17
chr17_53751268_53751419	0.18	TMEM100	transmembrane protein 100	47816	0.17
chr5_40389231_40389382	0.18	ENSG00000265615	.	68886	0.13
chr6_11723252_11723403	0.18	ADTRP	androgen-dependent TFPI-regulating protein	12562	0.23
chr13_101169763_101170057	0.18	PCCA	propionyl CoA carboxylase, alpha polypeptide	2229	0.29
chr12_32120851_32121108	0.18	KIAA1551	KIAA1551	5556	0.26
chr1_117528994_117529403	0.18	CD101	CD101 molecule	15184	0.16
chr13_78299226_78299481	0.18	SLAIN1	SLAIN motif family, member 1	5620	0.25
chr18_61066853_61067004	0.18	VPS4B	vacuolar protein sorting 4 homolog B (S. cerevisiae)	22695	0.14
chr21_19169610_19169884	0.18	AL109761.5		3942	0.27
chr8_53623079_53623230	0.18	RB1CC1	RB1-inducible coiled-coil 1	3829	0.28
chr10_14725736_14725887	0.18	ENSG00000201766	.	20318	0.19
chr6_11356607_11356758	0.18	NEDD9	neural precursor cell expressed, developmentally down-regulated 9	25850	0.24
chr5_86637358_86637509	0.18	CTC-428H11.2		35564	0.13
chr4_36242678_36242829	0.18	ARAP2	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2	2808	0.27
chr17_8856345_8856605	0.18	PIK3R5	phosphoinositide-3-kinase, regulatory subunit 5	12549	0.23
chr12_50615582_50615733	0.18	LIMA1	LIM domain and actin binding 1	474	0.69
chr1_44739830_44740020	0.18	ERI3-IT1	ERI3 intronic transcript 1 (non-protein coding)	29980	0.14
chr8_19553038_19553384	0.18	CSGALNACT1	chondroitin sulfate N-acetylgalactosaminyltransferase 1	12939	0.29
chr11_73470404_73470729	0.18	RAB6A	RAB6A, member RAS oncogene family	572	0.58
chr5_130968340_130968491	0.18	RAPGEF6	Rap guanine nucleotide exchange factor (GEF) 6	2308	0.43
chr1_186585585_186585736	0.18	PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	63899	0.13
chr9_82199849_82200000	0.18	TLE4	transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)	11320	0.33
chr2_143913849_143914048	0.18	RP11-190J23.1		15793	0.24
chr3_138534451_138534602	0.18	PIK3CB	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta	19068	0.24
chr10_11187947_11188252	0.18	CELF2	CUGBP, Elav-like family member 2	18894	0.19
chr10_98464854_98465114	0.18	PIK3AP1	phosphoinositide-3-kinase adaptor protein 1	15287	0.2
chr13_77591855_77592006	0.18	FBXL3	F-box and leucine-rich repeat protein 3	9355	0.18
chr12_8725236_8725579	0.18	ENSG00000238943	.	19665	0.12
chr14_59952044_59952346	0.18	JKAMP	JNK1/MAPK8-associated membrane protein	406	0.74
chr16_53550821_53550972	0.18	AKTIP	AKT interacting protein	12573	0.21
chr2_48479325_48479476	0.18	ENSG00000201010	.	34686	0.19
chr14_75715757_75716020	0.18	RP11-293M10.2		10226	0.15

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of POU3F3_POU3F4

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.6	GO:0001911	negative regulation of leukocyte mediated cytotoxicity(GO:0001911)
0.1	0.5	GO:0046398	UDP-glucuronate metabolic process(GO:0046398)
0.1	0.4	GO:0030854	positive regulation of granulocyte differentiation(GO:0030854)
0.1	0.3	GO:0046137	negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137)
0.1	0.2	GO:0031946	regulation of glucocorticoid biosynthetic process(GO:0031946)
0.1	0.3	GO:0002513	tolerance induction to self antigen(GO:0002513)
0.1	0.8	GO:0006491	N-glycan processing(GO:0006491)
0.1	0.3	GO:0072033	renal vesicle formation(GO:0072033)
0.1	0.2	GO:0071481	cellular response to X-ray(GO:0071481)
0.1	0.6	GO:0007172	signal complex assembly(GO:0007172)
0.1	0.2	GO:0045589	regulation of regulatory T cell differentiation(GO:0045589)
0.1	0.3	GO:0002238	response to molecule of fungal origin(GO:0002238)
0.1	0.2	GO:0097709	connective tissue replacement involved in inflammatory response wound healing(GO:0002248) connective tissue replacement(GO:0097709)
0.1	0.3	GO:0030910	olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.1	0.2	GO:0015917	aminophospholipid transport(GO:0015917)
0.1	0.2	GO:0010040	response to iron(II) ion(GO:0010040)
0.1	0.2	GO:0001831	trophectodermal cellular morphogenesis(GO:0001831)
0.1	0.1	GO:0031062	positive regulation of histone methylation(GO:0031062)
0.1	0.3	GO:0019987	obsolete negative regulation of anti-apoptosis(GO:0019987)
0.1	0.2	GO:0010572	positive regulation of platelet activation(GO:0010572)
0.1	0.1	GO:0034393	positive regulation of muscle cell apoptotic process(GO:0010661) positive regulation of smooth muscle cell apoptotic process(GO:0034393)
0.1	0.3	GO:0007256	activation of JNKK activity(GO:0007256)
0.1	0.1	GO:0045066	regulatory T cell differentiation(GO:0045066)
0.1	0.2	GO:0032237	activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.1	0.2	GO:0018076	N-terminal peptidyl-lysine acetylation(GO:0018076)
0.1	0.6	GO:0043368	positive T cell selection(GO:0043368)
0.1	0.2	GO:0045722	positive regulation of gluconeogenesis(GO:0045722)
0.1	0.2	GO:0043320	natural killer cell activation involved in immune response(GO:0002323) natural killer cell degranulation(GO:0043320)
0.1	0.1	GO:0006089	lactate metabolic process(GO:0006089)
0.0	0.2	GO:0090286	cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.0	0.1	GO:0048003	antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003)
0.0	0.1	GO:0060298	positive regulation of sarcomere organization(GO:0060298)
0.0	0.1	GO:0046476	glycosylceramide biosynthetic process(GO:0046476)
0.0	0.4	GO:0050860	negative regulation of antigen receptor-mediated signaling pathway(GO:0050858) negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0	0.1	GO:0042996	regulation of Golgi to plasma membrane protein transport(GO:0042996)
0.0	0.2	GO:0032875	regulation of DNA endoreduplication(GO:0032875) negative regulation of DNA endoreduplication(GO:0032876) DNA endoreduplication(GO:0042023)
0.0	0.1	GO:0050862	positive regulation of T cell receptor signaling pathway(GO:0050862)
0.0	0.3	GO:0051294	establishment of mitotic spindle orientation(GO:0000132) establishment of spindle orientation(GO:0051294)
0.0	0.1	GO:0045084	positive regulation of interleukin-12 biosynthetic process(GO:0045084)
0.0	0.3	GO:0002834	regulation of response to tumor cell(GO:0002834) positive regulation of response to tumor cell(GO:0002836) regulation of immune response to tumor cell(GO:0002837) positive regulation of immune response to tumor cell(GO:0002839)
0.0	0.1	GO:0002475	antigen processing and presentation via MHC class Ib(GO:0002475)
0.0	0.3	GO:0051103	DNA ligation involved in DNA repair(GO:0051103)
0.0	0.3	GO:0030889	negative regulation of B cell proliferation(GO:0030889)
0.0	0.0	GO:0033689	negative regulation of osteoblast proliferation(GO:0033689)
0.0	0.1	GO:0002430	complement receptor mediated signaling pathway(GO:0002430)
0.0	0.1	GO:1903312	negative regulation of mRNA processing(GO:0050686) negative regulation of mRNA metabolic process(GO:1903312)
0.0	0.4	GO:0043550	regulation of lipid kinase activity(GO:0043550)
0.0	0.1	GO:0033629	negative regulation of cell adhesion mediated by integrin(GO:0033629)
0.0	0.1	GO:0010533	regulation of activation of Janus kinase activity(GO:0010533) positive regulation of activation of Janus kinase activity(GO:0010536)
0.0	0.1	GO:0032632	interleukin-3 production(GO:0032632)
0.0	0.1	GO:0001821	histamine secretion(GO:0001821)
0.0	0.1	GO:0006434	seryl-tRNA aminoacylation(GO:0006434)
0.0	0.1	GO:0002540	arachidonic acid metabolite production involved in inflammatory response(GO:0002538) leukotriene production involved in inflammatory response(GO:0002540)
0.0	0.1	GO:0034145	positive regulation of toll-like receptor 4 signaling pathway(GO:0034145)
0.0	0.3	GO:0060123	regulation of growth hormone secretion(GO:0060123)
0.0	0.1	GO:0048859	formation of anatomical boundary(GO:0048859)
0.0	0.1	GO:0045349	interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354)
0.0	0.1	GO:0000042	protein targeting to Golgi(GO:0000042) establishment of protein localization to Golgi(GO:0072600)
0.0	0.1	GO:0043653	mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.0	0.4	GO:0006607	NLS-bearing protein import into nucleus(GO:0006607)
0.0	0.2	GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518) negative regulation of signal transduction by p53 class mediator(GO:1901797)
0.0	0.2	GO:0033235	positive regulation of protein sumoylation(GO:0033235)
0.0	0.1	GO:0031936	negative regulation of chromatin silencing(GO:0031936)
0.0	0.2	GO:0030206	chondroitin sulfate biosynthetic process(GO:0030206)
0.0	0.1	GO:0002523	leukocyte migration involved in inflammatory response(GO:0002523)
0.0	0.2	GO:0006610	ribosomal protein import into nucleus(GO:0006610)
0.0	0.0	GO:0042508	tyrosine phosphorylation of Stat1 protein(GO:0042508)
0.0	0.1	GO:0046101	hypoxanthine biosynthetic process(GO:0046101)
0.0	0.6	GO:0045730	respiratory burst(GO:0045730)
0.0	0.2	GO:0043984	histone H4-K16 acetylation(GO:0043984)
0.0	0.1	GO:0015691	cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
0.0	0.2	GO:0042989	sequestering of actin monomers(GO:0042989)
0.0	0.1	GO:0035405	histone-threonine phosphorylation(GO:0035405)
0.0	0.1	GO:0002507	tolerance induction(GO:0002507)
0.0	0.1	GO:0072531	pyrimidine-containing compound transmembrane transport(GO:0072531)
0.0	0.1	GO:0070682	proteasome regulatory particle assembly(GO:0070682)
0.0	0.1	GO:0009048	dosage compensation by inactivation of X chromosome(GO:0009048)
0.0	0.2	GO:0033169	histone H3-K9 demethylation(GO:0033169)
0.0	0.1	GO:0060136	embryonic process involved in female pregnancy(GO:0060136)
0.0	0.1	GO:0021898	commitment of multipotent stem cells to neuronal lineage in forebrain(GO:0021898)
0.0	0.1	GO:0003056	regulation of vascular smooth muscle contraction(GO:0003056)
0.0	0.2	GO:0030033	microvillus assembly(GO:0030033) microvillus organization(GO:0032528)
0.0	0.1	GO:0002902	regulation of B cell apoptotic process(GO:0002902)
0.0	0.2	GO:0006824	cobalt ion transport(GO:0006824)
0.0	0.2	GO:0022027	interkinetic nuclear migration(GO:0022027)
0.0	0.2	GO:0008611	ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
0.0	0.1	GO:0031580	membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.0	0.1	GO:1901522	positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.0	0.1	GO:0002710	negative regulation of T cell mediated immunity(GO:0002710)
0.0	0.1	GO:0033314	mitotic DNA replication checkpoint(GO:0033314)
0.0	0.1	GO:0002335	mature B cell differentiation(GO:0002335)
0.0	0.4	GO:0046854	phosphatidylinositol phosphorylation(GO:0046854)
0.0	0.3	GO:0019059	obsolete initiation of viral infection(GO:0019059)
0.0	0.1	GO:0045767	obsolete regulation of anti-apoptosis(GO:0045767)
0.0	0.3	GO:0000381	regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0	0.1	GO:0007023	post-chaperonin tubulin folding pathway(GO:0007023)
0.0	0.4	GO:0016578	histone deubiquitination(GO:0016578)
0.0	0.1	GO:0042088	T-helper 1 type immune response(GO:0042088)
0.0	0.1	GO:0006924	activation-induced cell death of T cells(GO:0006924)
0.0	0.1	GO:0007042	lysosomal lumen acidification(GO:0007042) regulation of lysosomal lumen pH(GO:0035751)
0.0	0.1	GO:0002885	positive regulation of hypersensitivity(GO:0002885)
0.0	0.1	GO:0006189	'de novo' IMP biosynthetic process(GO:0006189)
0.0	1.5	GO:0050852	T cell receptor signaling pathway(GO:0050852)
0.0	0.1	GO:0000154	rRNA modification(GO:0000154)
0.0	0.1	GO:0002823	negative regulation of adaptive immune response(GO:0002820) negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains(GO:0002823)
0.0	0.1	GO:0045292	mRNA cis splicing, via spliceosome(GO:0045292)
0.0	0.1	GO:0035610	C-terminal protein deglutamylation(GO:0035609) protein side chain deglutamylation(GO:0035610)
0.0	0.1	GO:0002691	regulation of cellular extravasation(GO:0002691) positive regulation of cellular extravasation(GO:0002693)
0.0	0.2	GO:0032733	positive regulation of interleukin-10 production(GO:0032733)
0.0	0.6	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.0	0.1	GO:0006290	pyrimidine dimer repair(GO:0006290)
0.0	0.1	GO:0030174	regulation of DNA-dependent DNA replication initiation(GO:0030174)
0.0	0.2	GO:0015904	tetracycline transport(GO:0015904)
0.0	0.1	GO:0042518	negative regulation of tyrosine phosphorylation of Stat3 protein(GO:0042518)
0.0	0.1	GO:0022614	membrane to membrane docking(GO:0022614)
0.0	0.3	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0	0.1	GO:0001672	regulation of chromatin assembly or disassembly(GO:0001672)
0.0	0.1	GO:0006922	obsolete cleavage of lamin involved in execution phase of apoptosis(GO:0006922)
0.0	0.1	GO:0042723	thiamine-containing compound metabolic process(GO:0042723)
0.0	0.0	GO:0030490	maturation of SSU-rRNA(GO:0030490)
0.0	0.0	GO:0001866	NK T cell proliferation(GO:0001866)
0.0	0.1	GO:0001661	conditioned taste aversion(GO:0001661)
0.0	0.2	GO:0005513	detection of calcium ion(GO:0005513)
0.0	0.1	GO:0051016	barbed-end actin filament capping(GO:0051016)
0.0	0.0	GO:0035930	corticosteroid hormone secretion(GO:0035930) regulation of steroid hormone secretion(GO:2000831) regulation of corticosteroid hormone secretion(GO:2000846)
0.0	0.1	GO:0046952	ketone body catabolic process(GO:0046952)
0.0	0.1	GO:0035162	embryonic hemopoiesis(GO:0035162)
0.0	0.0	GO:0010831	positive regulation of myotube differentiation(GO:0010831)
0.0	0.1	GO:0045603	positive regulation of endothelial cell differentiation(GO:0045603)
0.0	0.1	GO:0042987	amyloid precursor protein catabolic process(GO:0042987)
0.0	0.1	GO:0034371	chylomicron remodeling(GO:0034371)
0.0	0.1	GO:0034755	iron ion transmembrane transport(GO:0034755)
0.0	0.6	GO:0000289	nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.0	0.0	GO:0035066	positive regulation of histone acetylation(GO:0035066) positive regulation of protein acetylation(GO:1901985) positive regulation of peptidyl-lysine acetylation(GO:2000758)
0.0	0.1	GO:0048808	male genitalia morphogenesis(GO:0048808) male anatomical structure morphogenesis(GO:0090598)
0.0	0.1	GO:1902101	positive regulation of mitotic metaphase/anaphase transition(GO:0045842) positive regulation of mitotic sister chromatid separation(GO:1901970) positive regulation of metaphase/anaphase transition of cell cycle(GO:1902101)
0.0	0.3	GO:0051568	histone H3-K4 methylation(GO:0051568)
0.0	0.1	GO:0048496	maintenance of organ identity(GO:0048496)
0.0	0.1	GO:0031053	primary miRNA processing(GO:0031053)
0.0	0.1	GO:0010216	maintenance of DNA methylation(GO:0010216)
0.0	0.0	GO:0002282	microglial cell activation involved in immune response(GO:0002282)
0.0	0.1	GO:0051458	corticotropin secretion(GO:0051458) regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461)
0.0	0.0	GO:0006925	inflammatory cell apoptotic process(GO:0006925)
0.0	0.0	GO:0009129	pyrimidine nucleoside monophosphate metabolic process(GO:0009129)
0.0	0.1	GO:0032486	Rap protein signal transduction(GO:0032486)
0.0	0.2	GO:0042994	cytoplasmic sequestering of transcription factor(GO:0042994)
0.0	0.1	GO:0002025	vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure(GO:0002025)
0.0	0.3	GO:0016601	Rac protein signal transduction(GO:0016601)
0.0	0.1	GO:0090195	chemokine secretion(GO:0090195) regulation of chemokine secretion(GO:0090196) positive regulation of chemokine secretion(GO:0090197)
0.0	0.1	GO:0034626	fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0	0.0	GO:0010989	negative regulation of low-density lipoprotein particle clearance(GO:0010989)
0.0	0.1	GO:0048261	negative regulation of receptor-mediated endocytosis(GO:0048261)
0.0	0.1	GO:0009051	pentose-phosphate shunt, oxidative branch(GO:0009051)
0.0	0.1	GO:0006269	DNA replication, synthesis of RNA primer(GO:0006269)
0.0	0.1	GO:0019532	oxalate transport(GO:0019532)
0.0	0.2	GO:0006067	ethanol metabolic process(GO:0006067) ethanol oxidation(GO:0006069)
0.0	0.0	GO:0033632	regulation of cell-cell adhesion mediated by integrin(GO:0033632)
0.0	0.2	GO:0002286	T cell activation involved in immune response(GO:0002286)
0.0	0.1	GO:0009151	purine deoxyribonucleotide metabolic process(GO:0009151)
0.0	0.1	GO:0006432	phenylalanyl-tRNA aminoacylation(GO:0006432)
0.0	0.1	GO:0016322	neuron remodeling(GO:0016322)
0.0	0.0	GO:0010815	bradykinin catabolic process(GO:0010815)
0.0	0.1	GO:0014742	positive regulation of cardiac muscle hypertrophy(GO:0010613) positive regulation of muscle hypertrophy(GO:0014742)
0.0	0.0	GO:0090322	regulation of superoxide metabolic process(GO:0090322)
0.0	0.0	GO:0001916	positive regulation of T cell mediated cytotoxicity(GO:0001916)
0.0	0.1	GO:0032922	circadian regulation of gene expression(GO:0032922)
0.0	0.1	GO:0030186	melatonin metabolic process(GO:0030186) melatonin biosynthetic process(GO:0030187)
0.0	0.2	GO:0006613	cotranslational protein targeting to membrane(GO:0006613)
0.0	0.1	GO:0048096	chromatin-mediated maintenance of transcription(GO:0048096)
0.0	0.0	GO:0010988	regulation of low-density lipoprotein particle clearance(GO:0010988)
0.0	0.1	GO:0031664	regulation of lipopolysaccharide-mediated signaling pathway(GO:0031664)
0.0	0.0	GO:0032641	lymphotoxin A production(GO:0032641) lymphotoxin A biosynthetic process(GO:0042109)
0.0	0.0	GO:0006681	galactosylceramide metabolic process(GO:0006681)
0.0	0.1	GO:0046852	positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852)
0.0	0.1	GO:0032703	negative regulation of interleukin-2 production(GO:0032703)
0.0	0.1	GO:0060710	chorio-allantoic fusion(GO:0060710)
0.0	0.0	GO:0048304	positive regulation of isotype switching to IgG isotypes(GO:0048304)
0.0	0.2	GO:0010390	histone monoubiquitination(GO:0010390)
0.0	0.1	GO:0006689	ganglioside catabolic process(GO:0006689)
0.0	0.1	GO:0045586	regulation of gamma-delta T cell differentiation(GO:0045586) positive regulation of gamma-delta T cell differentiation(GO:0045588) regulation of gamma-delta T cell activation(GO:0046643) positive regulation of gamma-delta T cell activation(GO:0046645)
0.0	0.2	GO:0015671	oxygen transport(GO:0015671)
0.0	0.3	GO:0060334	regulation of response to interferon-gamma(GO:0060330) regulation of interferon-gamma-mediated signaling pathway(GO:0060334)
0.0	0.1	GO:1902931	negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206) negative regulation of alcohol biosynthetic process(GO:1902931)
0.0	0.0	GO:1903299	regulation of glucokinase activity(GO:0033131) positive regulation of glucokinase activity(GO:0033133) regulation of hexokinase activity(GO:1903299) positive regulation of hexokinase activity(GO:1903301)
0.0	0.1	GO:0032075	positive regulation of nuclease activity(GO:0032075)
0.0	0.1	GO:0032227	negative regulation of synaptic transmission, dopaminergic(GO:0032227)
0.0	0.1	GO:0045040	outer mitochondrial membrane organization(GO:0007008) protein import into mitochondrial outer membrane(GO:0045040)
0.0	0.1	GO:0043247	protection from non-homologous end joining at telomere(GO:0031848) telomere maintenance in response to DNA damage(GO:0043247)
0.0	0.1	GO:0016255	attachment of GPI anchor to protein(GO:0016255)
0.0	0.0	GO:0000966	RNA 5'-end processing(GO:0000966)
0.0	0.1	GO:0000270	peptidoglycan metabolic process(GO:0000270) peptidoglycan catabolic process(GO:0009253)
0.0	0.2	GO:0070536	protein K63-linked deubiquitination(GO:0070536)
0.0	0.4	GO:0031295	lymphocyte costimulation(GO:0031294) T cell costimulation(GO:0031295)
0.0	0.0	GO:0046834	lipid phosphorylation(GO:0046834)
0.0	0.1	GO:0002717	positive regulation of natural killer cell mediated immunity(GO:0002717) positive regulation of natural killer cell mediated cytotoxicity(GO:0045954)
0.0	0.4	GO:0051865	protein autoubiquitination(GO:0051865)
0.0	0.0	GO:0002438	acute inflammatory response to antigenic stimulus(GO:0002438)
0.0	0.0	GO:0019372	lipoxygenase pathway(GO:0019372)
0.0	0.0	GO:0060535	trachea cartilage morphogenesis(GO:0060535) cartilage morphogenesis(GO:0060536)
0.0	0.0	GO:0014826	vein smooth muscle contraction(GO:0014826)
0.0	0.1	GO:0006422	aspartyl-tRNA aminoacylation(GO:0006422)
0.0	0.2	GO:0043252	sodium-independent organic anion transport(GO:0043252)
0.0	0.1	GO:0030263	apoptotic chromosome condensation(GO:0030263)
0.0	0.1	GO:0045793	positive regulation of cell size(GO:0045793)
0.0	0.0	GO:0010574	vascular endothelial growth factor production(GO:0010573) regulation of vascular endothelial growth factor production(GO:0010574)
0.0	0.3	GO:0043484	regulation of RNA splicing(GO:0043484)
0.0	0.0	GO:0034421	post-translational protein acetylation(GO:0034421)
0.0	0.1	GO:0045647	negative regulation of erythrocyte differentiation(GO:0045647)
0.0	0.1	GO:0046827	positive regulation of protein export from nucleus(GO:0046827)
0.0	0.1	GO:0015864	pyrimidine nucleoside transport(GO:0015864)
0.0	0.1	GO:0042226	interleukin-6 biosynthetic process(GO:0042226)
0.0	0.1	GO:0000266	mitochondrial fission(GO:0000266)
0.0	0.0	GO:0060743	epithelial cell maturation involved in prostate gland development(GO:0060743)
0.0	0.0	GO:0042362	fat-soluble vitamin biosynthetic process(GO:0042362)
0.0	0.2	GO:0042273	ribosomal large subunit biogenesis(GO:0042273)
0.0	0.0	GO:0030581	intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) regulation by virus of viral protein levels in host cell(GO:0046719) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708)
0.0	0.0	GO:0034143	regulation of toll-like receptor 4 signaling pathway(GO:0034143)
0.0	0.1	GO:0042339	keratan sulfate metabolic process(GO:0042339)
0.0	0.1	GO:0045003	DNA recombinase assembly(GO:0000730) double-strand break repair via synthesis-dependent strand annealing(GO:0045003)
0.0	0.1	GO:0021684	cerebellar granular layer development(GO:0021681) cerebellar granular layer morphogenesis(GO:0021683) cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.0	0.1	GO:0006513	protein monoubiquitination(GO:0006513)
0.0	0.1	GO:0010508	positive regulation of autophagy(GO:0010508)
0.0	0.1	GO:0034629	cellular protein complex localization(GO:0034629)
0.0	0.0	GO:1903429	regulation of neuron maturation(GO:0014041) regulation of cell maturation(GO:1903429)
0.0	0.4	GO:0006305	DNA alkylation(GO:0006305) DNA methylation(GO:0006306)
0.0	0.3	GO:0016254	preassembly of GPI anchor in ER membrane(GO:0016254)
0.0	0.1	GO:0000380	alternative mRNA splicing, via spliceosome(GO:0000380)
0.0	0.9	GO:0008360	regulation of cell shape(GO:0008360)
0.0	0.1	GO:2000258	negative regulation of humoral immune response(GO:0002921) negative regulation of complement activation(GO:0045916) negative regulation of protein activation cascade(GO:2000258)
0.0	0.0	GO:0009313	oligosaccharide catabolic process(GO:0009313)
0.0	0.0	GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process(GO:0051770)
0.0	0.0	GO:0035455	response to interferon-alpha(GO:0035455)
0.0	0.0	GO:0043568	positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568)
0.0	0.2	GO:0071044	histone mRNA catabolic process(GO:0071044)
0.0	0.0	GO:0048537	mucosal-associated lymphoid tissue development(GO:0048537)
0.0	0.0	GO:0032506	cytokinetic process(GO:0032506)
0.0	0.0	GO:0034391	smooth muscle cell apoptotic process(GO:0034390) regulation of smooth muscle cell apoptotic process(GO:0034391)
0.0	0.1	GO:0042403	thyroid hormone metabolic process(GO:0042403)
0.0	0.4	GO:0016579	protein deubiquitination(GO:0016579)
0.0	0.0	GO:0060534	trachea cartilage development(GO:0060534)
0.0	0.3	GO:0034199	activation of protein kinase A activity(GO:0034199)
0.0	0.0	GO:0072216	positive regulation of metanephros development(GO:0072216)
0.0	0.0	GO:0032627	interleukin-23 production(GO:0032627) regulation of interleukin-23 production(GO:0032667) positive regulation of interleukin-23 production(GO:0032747)
0.0	0.1	GO:0042094	interleukin-2 biosynthetic process(GO:0042094)
0.0	0.0	GO:0040016	embryonic cleavage(GO:0040016)
0.0	0.1	GO:0050910	detection of mechanical stimulus involved in sensory perception of sound(GO:0050910)
0.0	0.3	GO:0046131	pyrimidine ribonucleoside metabolic process(GO:0046131)
0.0	0.1	GO:0008628	hormone-mediated apoptotic signaling pathway(GO:0008628)
0.0	0.0	GO:0032814	regulation of natural killer cell activation(GO:0032814)
0.0	0.0	GO:0042832	defense response to protozoan(GO:0042832)
0.0	0.0	GO:0034587	piRNA metabolic process(GO:0034587)
0.0	0.1	GO:0046874	quinolinate metabolic process(GO:0046874)
0.0	0.3	GO:0006611	protein export from nucleus(GO:0006611)
0.0	0.1	GO:0008105	asymmetric protein localization(GO:0008105)
0.0	0.1	GO:0018345	protein palmitoylation(GO:0018345)
0.0	0.0	GO:0060049	regulation of protein glycosylation(GO:0060049)
0.0	0.4	GO:0000245	spliceosomal complex assembly(GO:0000245)
0.0	0.1	GO:0016572	histone phosphorylation(GO:0016572)
0.0	0.0	GO:0007100	mitotic centrosome separation(GO:0007100)
0.0	0.1	GO:0015780	nucleotide-sugar transport(GO:0015780)
0.0	0.1	GO:0043628	ncRNA 3'-end processing(GO:0043628)
0.0	0.0	GO:0071157	negative regulation of cell cycle arrest(GO:0071157)
0.0	0.0	GO:0033194	response to hydroperoxide(GO:0033194)
0.0	0.0	GO:0009415	response to water deprivation(GO:0009414) response to water(GO:0009415)
0.0	0.1	GO:0000012	single strand break repair(GO:0000012)
0.0	0.1	GO:0008634	obsolete negative regulation of survival gene product expression(GO:0008634)
0.0	0.1	GO:0035246	peptidyl-arginine N-methylation(GO:0035246)
0.0	0.0	GO:0003057	regulation of the force of heart contraction by chemical signal(GO:0003057)
0.0	0.2	GO:0045576	mast cell activation(GO:0045576)
0.0	0.0	GO:0044320	cellular response to leptin stimulus(GO:0044320) response to leptin(GO:0044321)
0.0	0.0	GO:0006003	fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0	0.0	GO:0031293	membrane protein intracellular domain proteolysis(GO:0031293)
0.0	0.0	GO:0090232	positive regulation of spindle checkpoint(GO:0090232) regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267) positive regulation of cell cycle checkpoint(GO:1901978) regulation of mitotic spindle checkpoint(GO:1903504)
0.0	0.1	GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress(GO:0008631) cell death in response to oxidative stress(GO:0036473)
0.0	0.1	GO:0032988	ribonucleoprotein complex disassembly(GO:0032988)
0.0	0.0	GO:0002448	mast cell mediated immunity(GO:0002448)
0.0	0.0	GO:0034501	protein localization to kinetochore(GO:0034501)
0.0	0.0	GO:0042435	indole-containing compound biosynthetic process(GO:0042435)
0.0	0.1	GO:0044245	polysaccharide digestion(GO:0044245)
0.0	0.0	GO:0010979	regulation of vitamin D 24-hydroxylase activity(GO:0010979) positive regulation of vitamin D 24-hydroxylase activity(GO:0010980)
0.0	0.0	GO:0006515	misfolded or incompletely synthesized protein catabolic process(GO:0006515)
0.0	0.1	GO:0032897	negative regulation of viral transcription(GO:0032897)
0.0	0.0	GO:0048488	synaptic vesicle recycling(GO:0036465) synaptic vesicle endocytosis(GO:0048488) clathrin-mediated endocytosis(GO:0072583)
0.0	0.1	GO:0045745	positive regulation of G-protein coupled receptor protein signaling pathway(GO:0045745)
0.0	0.1	GO:0051532	NFAT protein import into nucleus(GO:0051531) regulation of NFAT protein import into nucleus(GO:0051532)
0.0	0.0	GO:0050765	negative regulation of phagocytosis(GO:0050765)
0.0	0.0	GO:0051657	maintenance of organelle location(GO:0051657)
0.0	0.0	GO:0010592	positive regulation of lamellipodium assembly(GO:0010592) positive regulation of lamellipodium organization(GO:1902745)
0.0	0.2	GO:0000083	regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.0	0.1	GO:0060539	diaphragm development(GO:0060539)
0.0	0.0	GO:0043162	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.0	0.1	GO:0046519	sphingoid metabolic process(GO:0046519)
0.0	0.1	GO:0006999	nuclear pore organization(GO:0006999)
0.0	0.0	GO:0034085	establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
0.0	0.0	GO:0060586	multicellular organismal iron ion homeostasis(GO:0060586)
0.0	0.1	GO:0006111	regulation of gluconeogenesis(GO:0006111)
0.0	0.0	GO:0019883	antigen processing and presentation of endogenous antigen(GO:0019883)
0.0	0.0	GO:0051131	chaperone-mediated protein complex assembly(GO:0051131)
0.0	0.0	GO:0051382	kinetochore assembly(GO:0051382)
0.0	0.2	GO:0007032	endosome organization(GO:0007032)
0.0	0.2	GO:0050832	defense response to fungus(GO:0050832)
0.0	0.0	GO:0060291	long-term synaptic potentiation(GO:0060291)
0.0	0.1	GO:0071230	cellular response to amino acid stimulus(GO:0071230)
0.0	0.0	GO:0006474	N-terminal protein amino acid acetylation(GO:0006474)
0.0	0.1	GO:0060040	retinal bipolar neuron differentiation(GO:0060040)
0.0	0.0	GO:0045725	positive regulation of glycogen biosynthetic process(GO:0045725)
0.0	0.0	GO:0001832	blastocyst growth(GO:0001832)
0.0	0.2	GO:0006071	glycerol metabolic process(GO:0006071)
0.0	0.0	GO:1903008	organelle disassembly(GO:1903008)
0.0	0.0	GO:0007064	mitotic sister chromatid cohesion(GO:0007064)
0.0	0.1	GO:0071333	cellular response to monosaccharide stimulus(GO:0071326) cellular response to hexose stimulus(GO:0071331) cellular response to glucose stimulus(GO:0071333)
0.0	0.1	GO:0032456	endocytic recycling(GO:0032456)
0.0	0.0	GO:0006337	nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.0	0.0	GO:0071688	skeletal muscle myosin thick filament assembly(GO:0030241) myosin filament organization(GO:0031033) myosin filament assembly(GO:0031034) striated muscle myosin thick filament assembly(GO:0071688)
0.0	0.1	GO:0003084	positive regulation of systemic arterial blood pressure(GO:0003084)
0.0	0.2	GO:0036503	ER-associated ubiquitin-dependent protein catabolic process(GO:0030433) ERAD pathway(GO:0036503)
0.0	0.1	GO:0000050	urea cycle(GO:0000050)
0.0	0.1	GO:0051220	cytoplasmic sequestering of protein(GO:0051220)
0.0	0.0	GO:0009698	phenylpropanoid metabolic process(GO:0009698) coumarin metabolic process(GO:0009804)
0.0	0.0	GO:0016266	O-glycan processing(GO:0016266)
0.0	0.0	GO:0051767	nitric-oxide synthase biosynthetic process(GO:0051767) regulation of nitric-oxide synthase biosynthetic process(GO:0051769)
0.0	0.0	GO:0032692	negative regulation of interleukin-1 production(GO:0032692)
0.0	0.1	GO:0009650	UV protection(GO:0009650)
0.0	0.1	GO:0046348	amino sugar catabolic process(GO:0046348) glucosamine-containing compound catabolic process(GO:1901072)
0.0	0.1	GO:0051319	mitotic G2 phase(GO:0000085) G2 phase(GO:0051319)
0.0	0.0	GO:0060676	ureteric bud formation(GO:0060676)
0.0	0.0	GO:0046885	regulation of hormone biosynthetic process(GO:0046885)
0.0	0.0	GO:0070102	interleukin-6-mediated signaling pathway(GO:0070102)
0.0	0.0	GO:0010739	positive regulation of protein kinase A signaling(GO:0010739)
0.0	0.0	GO:0052251	induction by organism of defense response of other organism involved in symbiotic interaction(GO:0052251)
0.0	0.1	GO:0048255	RNA stabilization(GO:0043489) mRNA stabilization(GO:0048255)
0.0	0.0	GO:0043461	proton-transporting ATP synthase complex assembly(GO:0043461) proton-transporting ATP synthase complex biogenesis(GO:0070272)
0.0	0.0	GO:0045945	positive regulation of transcription from RNA polymerase III promoter(GO:0045945)
0.0	0.1	GO:0035335	peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0	0.1	GO:0071577	zinc II ion transmembrane transport(GO:0071577)
0.0	0.2	GO:0000288	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:0000288)
0.0	0.0	GO:0051647	nucleus localization(GO:0051647)
0.0	0.0	GO:0051451	myoblast migration(GO:0051451)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.9	GO:0001891	phagocytic cup(GO:0001891)
0.1	0.2	GO:0070022	transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.1	0.2	GO:0042105	alpha-beta T cell receptor complex(GO:0042105)
0.1	0.2	GO:0071942	XPC complex(GO:0071942)
0.1	0.2	GO:0072487	MSL complex(GO:0072487)
0.1	0.2	GO:0071664	catenin-TCF7L2 complex(GO:0071664)
0.1	0.2	GO:0005827	polar microtubule(GO:0005827)
0.1	0.3	GO:0005797	Golgi medial cisterna(GO:0005797)
0.0	0.2	GO:0034992	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0	0.3	GO:0031264	death-inducing signaling complex(GO:0031264)
0.0	0.2	GO:0043218	compact myelin(GO:0043218)
0.0	0.2	GO:0001740	Barr body(GO:0001740)
0.0	0.1	GO:0000942	condensed nuclear chromosome outer kinetochore(GO:0000942)
0.0	0.1	GO:0005784	Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.0	0.1	GO:0031229	integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.0	0.4	GO:0001772	immunological synapse(GO:0001772)
0.0	0.2	GO:0030121	AP-1 adaptor complex(GO:0030121)
0.0	0.2	GO:0031088	platelet dense granule membrane(GO:0031088)
0.0	0.7	GO:0005637	nuclear inner membrane(GO:0005637)
0.0	0.3	GO:0016471	vacuolar proton-transporting V-type ATPase complex(GO:0016471)
0.0	0.4	GO:0005942	phosphatidylinositol 3-kinase complex(GO:0005942)
0.0	0.1	GO:0032444	activin responsive factor complex(GO:0032444)
0.0	0.4	GO:0010494	cytoplasmic stress granule(GO:0010494)
0.0	0.2	GO:0014731	spectrin-associated cytoskeleton(GO:0014731)
0.0	0.1	GO:0005896	interleukin-6 receptor complex(GO:0005896)
0.0	0.1	GO:0033256	I-kappaB/NF-kappaB complex(GO:0033256)
0.0	0.1	GO:0001931	uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0	0.2	GO:0019773	proteasome core complex, alpha-subunit complex(GO:0019773)
0.0	0.1	GO:0032279	asymmetric synapse(GO:0032279) neuron to neuron synapse(GO:0098984)
0.0	0.1	GO:0030061	mitochondrial crista(GO:0030061)
0.0	0.2	GO:0005658	alpha DNA polymerase:primase complex(GO:0005658)
0.0	0.4	GO:0016514	SWI/SNF complex(GO:0016514)
0.0	0.1	GO:0030870	Mre11 complex(GO:0030870)
0.0	0.2	GO:0070419	nonhomologous end joining complex(GO:0070419)
0.0	0.4	GO:0030530	obsolete heterogeneous nuclear ribonucleoprotein complex(GO:0030530)
0.0	0.2	GO:0008250	oligosaccharyltransferase complex(GO:0008250)
0.0	0.2	GO:0042101	T cell receptor complex(GO:0042101)
0.0	0.1	GO:0071986	Ragulator complex(GO:0071986)
0.0	0.1	GO:0031465	Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.0	0.1	GO:0042582	primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.0	0.1	GO:0008540	proteasome regulatory particle, base subcomplex(GO:0008540)
0.0	0.2	GO:0048786	presynaptic active zone(GO:0048786)
0.0	0.1	GO:0000347	THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.0	0.7	GO:0005626	obsolete insoluble fraction(GO:0005626)
0.0	0.1	GO:0042627	chylomicron(GO:0042627)
0.0	0.2	GO:0005868	cytoplasmic dynein complex(GO:0005868)
0.0	0.1	GO:0030062	mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.0	0.0	GO:0031313	extrinsic component of vacuolar membrane(GO:0000306) extrinsic component of endosome membrane(GO:0031313)
0.0	0.1	GO:0033270	paranode region of axon(GO:0033270)
0.0	0.1	GO:0031205	endoplasmic reticulum Sec complex(GO:0031205)
0.0	0.3	GO:0005892	acetylcholine-gated channel complex(GO:0005892)
0.0	0.1	GO:0000800	lateral element(GO:0000800)
0.0	0.2	GO:0005952	cAMP-dependent protein kinase complex(GO:0005952)
0.0	0.0	GO:0000805	X chromosome(GO:0000805)
0.0	0.2	GO:0043020	NADPH oxidase complex(GO:0043020)
0.0	0.1	GO:0016593	Cdc73/Paf1 complex(GO:0016593)
0.0	0.1	GO:0042765	GPI-anchor transamidase complex(GO:0042765)
0.0	0.1	GO:0000153	cytoplasmic ubiquitin ligase complex(GO:0000153)
0.0	0.1	GO:0070695	FHF complex(GO:0070695)
0.0	0.3	GO:0000159	protein phosphatase type 2A complex(GO:0000159)
0.0	0.4	GO:0019005	SCF ubiquitin ligase complex(GO:0019005)
0.0	0.2	GO:0034362	low-density lipoprotein particle(GO:0034362)
0.0	0.0	GO:0031618	nuclear pericentric heterochromatin(GO:0031618)
0.0	0.1	GO:0034045	pre-autophagosomal structure membrane(GO:0034045)
0.0	0.1	GO:0034518	mRNA cap binding complex(GO:0005845) RNA cap binding complex(GO:0034518)
0.0	0.1	GO:0048500	signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.0	0.8	GO:0016605	PML body(GO:0016605)
0.0	0.2	GO:0019908	nuclear cyclin-dependent protein kinase holoenzyme complex(GO:0019908)
0.0	0.0	GO:0005686	U2 snRNP(GO:0005686)
0.0	0.0	GO:0045240	dihydrolipoyl dehydrogenase complex(GO:0045240)
0.0	0.1	GO:0005750	mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.0	0.0	GO:0035145	exon-exon junction complex(GO:0035145)
0.0	0.0	GO:0000346	transcription export complex(GO:0000346)
0.0	0.1	GO:0031010	ISWI-type complex(GO:0031010)
0.0	0.1	GO:0000444	MIS12/MIND type complex(GO:0000444)
0.0	0.1	GO:0031080	nuclear pore outer ring(GO:0031080)
0.0	0.4	GO:0030175	filopodium(GO:0030175)
0.0	0.1	GO:0030688	preribosome, small subunit precursor(GO:0030688)
0.0	0.1	GO:0070688	MLL5-L complex(GO:0070688)
0.0	0.1	GO:0042583	chromaffin granule(GO:0042583) chromaffin granule membrane(GO:0042584)
0.0	0.2	GO:0042613	MHC class II protein complex(GO:0042613)
0.0	0.1	GO:0005641	nuclear envelope lumen(GO:0005641)
0.0	0.1	GO:0042598	obsolete vesicular fraction(GO:0042598)
0.0	0.1	GO:0005672	transcription factor TFIIA complex(GO:0005672)
0.0	0.1	GO:0016602	CCAAT-binding factor complex(GO:0016602)
0.0	0.0	GO:0016533	cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.0	0.1	GO:0070531	BRCA1-A complex(GO:0070531)
0.0	0.0	GO:0032009	early phagosome(GO:0032009)
0.0	0.2	GO:0000315	organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0	0.1	GO:0030904	retromer complex(GO:0030904)
0.0	0.0	GO:0031932	TORC2 complex(GO:0031932)
0.0	0.1	GO:0008290	F-actin capping protein complex(GO:0008290)
0.0	0.1	GO:0045120	pronucleus(GO:0045120)
0.0	0.1	GO:0032590	dendrite membrane(GO:0032590)
0.0	0.1	GO:0042599	lamellar body(GO:0042599)
0.0	0.1	GO:0002080	acrosomal membrane(GO:0002080)
0.0	0.1	GO:0045179	apical cortex(GO:0045179)
0.0	0.1	GO:0000145	exocyst(GO:0000145)
0.0	0.5	GO:0015934	large ribosomal subunit(GO:0015934)
0.0	0.1	GO:0070776	H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0	0.0	GO:0042827	platelet dense granule(GO:0042827)
0.0	0.5	GO:0055037	recycling endosome(GO:0055037)
0.0	0.0	GO:0005594	collagen type IX trimer(GO:0005594)
0.0	0.0	GO:0071438	invadopodium membrane(GO:0071438)
0.0	0.0	GO:0005964	phosphorylase kinase complex(GO:0005964)
0.0	0.1	GO:0008180	COP9 signalosome(GO:0008180)
0.0	1.1	GO:0016607	nuclear speck(GO:0016607)
0.0	0.0	GO:0032777	Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0	0.1	GO:0005869	dynactin complex(GO:0005869)
0.0	0.0	GO:0033553	rDNA heterochromatin(GO:0033553)
0.0	0.1	GO:0005883	neurofilament(GO:0005883)
0.0	0.4	GO:0030173	integral component of Golgi membrane(GO:0030173)
0.0	0.0	GO:0044298	neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.5	GO:0008454	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.1	0.2	GO:0001758	retinal dehydrogenase activity(GO:0001758)
0.1	0.4	GO:0070087	chromo shadow domain binding(GO:0070087)
0.1	0.2	GO:0004311	farnesyltranstransferase activity(GO:0004311)
0.1	0.2	GO:0033691	sialic acid binding(GO:0033691)
0.1	0.5	GO:0001784	phosphotyrosine binding(GO:0001784)
0.1	0.3	GO:0047238	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.1	0.2	GO:0003910	DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.1	0.2	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.1	0.2	GO:0005094	Rho GDP-dissociation inhibitor activity(GO:0005094)
0.1	0.2	GO:0016309	1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.1	1.4	GO:0001608	G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.1	0.2	GO:0030881	beta-2-microglobulin binding(GO:0030881)
0.1	0.2	GO:0030375	thyroid hormone receptor coactivator activity(GO:0030375)
0.1	0.2	GO:0042608	T cell receptor binding(GO:0042608)
0.1	0.2	GO:0004911	interleukin-2 receptor activity(GO:0004911)
0.1	0.3	GO:0052813	phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.1	0.4	GO:0070411	I-SMAD binding(GO:0070411)
0.1	0.2	GO:0032454	histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0	0.7	GO:0004697	protein kinase C activity(GO:0004697)
0.0	0.2	GO:0019911	structural constituent of myelin sheath(GO:0019911)
0.0	0.2	GO:0001846	opsonin binding(GO:0001846)
0.0	0.3	GO:0070569	uridylyltransferase activity(GO:0070569)
0.0	0.1	GO:0008545	JUN kinase kinase activity(GO:0008545)
0.0	0.3	GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0	0.1	GO:0031708	bombesin receptor binding(GO:0031705) endothelin B receptor binding(GO:0031708)
0.0	0.1	GO:0016882	cyclo-ligase activity(GO:0016882)
0.0	0.1	GO:0004875	complement receptor activity(GO:0004875)
0.0	0.7	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0	0.1	GO:0043533	inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.0	0.2	GO:0005131	growth hormone receptor binding(GO:0005131)
0.0	0.1	GO:0000404	heteroduplex DNA loop binding(GO:0000404)
0.0	0.1	GO:0005134	interleukin-2 receptor binding(GO:0005134)
0.0	0.1	GO:0004828	serine-tRNA ligase activity(GO:0004828)
0.0	0.2	GO:0016494	C-X-C chemokine receptor activity(GO:0016494)
0.0	0.1	GO:0000405	bubble DNA binding(GO:0000405)
0.0	0.2	GO:0005521	lamin binding(GO:0005521)
0.0	0.1	GO:0015038	glutathione disulfide oxidoreductase activity(GO:0015038)
0.0	0.2	GO:0034713	type I transforming growth factor beta receptor binding(GO:0034713)
0.0	0.4	GO:0030742	GTP-dependent protein binding(GO:0030742)
0.0	0.3	GO:0016493	C-C chemokine receptor activity(GO:0016493)
0.0	0.1	GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.0	0.2	GO:0015347	sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.0	0.2	GO:0035004	phosphatidylinositol 3-kinase activity(GO:0035004)
0.0	0.1	GO:0005275	amine transmembrane transporter activity(GO:0005275)
0.0	0.1	GO:0008109	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0	0.1	GO:0016972	thiol oxidase activity(GO:0016972)
0.0	0.3	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0	0.2	GO:0004908	interleukin-1 receptor activity(GO:0004908)
0.0	0.6	GO:0005164	tumor necrosis factor receptor binding(GO:0005164)
0.0	0.1	GO:0004974	leukotriene receptor activity(GO:0004974)
0.0	0.8	GO:0003950	NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0	0.2	GO:0015520	tetracycline:proton antiporter activity(GO:0015520)
0.0	0.5	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0	0.2	GO:0003988	acetyl-CoA C-acyltransferase activity(GO:0003988)
0.0	0.1	GO:0008745	N-acetylmuramoyl-L-alanine amidase activity(GO:0008745)
0.0	0.4	GO:0030159	receptor signaling complex scaffold activity(GO:0030159)
0.0	0.1	GO:0045118	azole transporter activity(GO:0045118) azole transmembrane transporter activity(GO:1901474)
0.0	0.4	GO:0005095	GTPase inhibitor activity(GO:0005095)
0.0	1.5	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)
0.0	0.2	GO:0019864	IgG binding(GO:0019864)
0.0	0.1	GO:0005350	pyrimidine nucleobase transmembrane transporter activity(GO:0005350)
0.0	0.1	GO:0004046	aminoacylase activity(GO:0004046)
0.0	0.3	GO:0030276	clathrin binding(GO:0030276)
0.0	0.4	GO:0031593	polyubiquitin binding(GO:0031593)
0.0	0.2	GO:0004691	cAMP-dependent protein kinase activity(GO:0004691)
0.0	0.1	GO:0043141	ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.0	0.1	GO:0016004	phospholipase activator activity(GO:0016004)
0.0	0.2	GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0	0.1	GO:0001848	complement binding(GO:0001848)
0.0	0.2	GO:0005338	nucleotide-sugar transmembrane transporter activity(GO:0005338)
0.0	0.2	GO:0035251	UDP-glucosyltransferase activity(GO:0035251)
0.0	0.0	GO:0042392	sphingosine-1-phosphate phosphatase activity(GO:0042392)
0.0	0.2	GO:0034593	phosphatidylinositol bisphosphate phosphatase activity(GO:0034593)
0.0	0.1	GO:0070410	co-SMAD binding(GO:0070410)
0.0	0.1	GO:0004514	nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514)
0.0	0.1	GO:0008474	palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0	0.0	GO:0046975	histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.0	0.8	GO:0003725	double-stranded RNA binding(GO:0003725)
0.0	0.1	GO:0019789	SUMO transferase activity(GO:0019789)
0.0	0.1	GO:0071723	lipopeptide binding(GO:0071723)
0.0	0.1	GO:0004775	succinate-CoA ligase (ADP-forming) activity(GO:0004775)
0.0	0.1	GO:0004339	glucan 1,4-alpha-glucosidase activity(GO:0004339)
0.0	0.0	GO:0060230	lipoprotein lipase activator activity(GO:0060230)
0.0	0.1	GO:0004062	aryl sulfotransferase activity(GO:0004062)
0.0	0.1	GO:0046404	ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734)
0.0	0.1	GO:0019237	centromeric DNA binding(GO:0019237)
0.0	0.1	GO:0016774	phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.0	0.2	GO:0008889	glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.0	0.4	GO:0005001	transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0	0.1	GO:0005138	interleukin-6 receptor binding(GO:0005138)
0.0	0.1	GO:0016417	S-acyltransferase activity(GO:0016417)
0.0	0.1	GO:0047756	chondroitin 4-sulfotransferase activity(GO:0047756)
0.0	0.1	GO:0004939	beta-adrenergic receptor activity(GO:0004939)
0.0	0.1	GO:0061133	endopeptidase activator activity(GO:0061133)
0.0	0.1	GO:0017159	pantetheine hydrolase activity(GO:0017159)
0.0	0.1	GO:0034235	GPI anchor binding(GO:0034235)
0.0	0.1	GO:0031849	olfactory receptor binding(GO:0031849)
0.0	0.7	GO:0036459	thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.0	0.1	GO:0019531	oxalate transmembrane transporter activity(GO:0019531)
0.0	0.1	GO:0004459	L-lactate dehydrogenase activity(GO:0004459)
0.0	0.1	GO:0050786	RAGE receptor binding(GO:0050786)
0.0	0.1	GO:0003828	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0	0.2	GO:0016175	superoxide-generating NADPH oxidase activity(GO:0016175)
0.0	0.1	GO:0061505	DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.0	0.1	GO:0032794	GTPase activating protein binding(GO:0032794)
0.0	0.1	GO:0005381	iron ion transmembrane transporter activity(GO:0005381)
0.0	0.1	GO:0005049	nuclear export signal receptor activity(GO:0005049)
0.0	0.1	GO:0004969	histamine receptor activity(GO:0004969)
0.0	0.1	GO:0016520	growth hormone-releasing hormone receptor activity(GO:0016520)
0.0	0.1	GO:0051864	histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0	0.5	GO:0019003	GDP binding(GO:0019003)
0.0	0.3	GO:0051721	protein phosphatase 2A binding(GO:0051721)
0.0	0.0	GO:0032138	single base insertion or deletion binding(GO:0032138)
0.0	0.2	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0	0.0	GO:0032135	DNA insertion or deletion binding(GO:0032135)
0.0	0.1	GO:0070579	methylcytosine dioxygenase activity(GO:0070579)
0.0	0.1	GO:0030332	cyclin binding(GO:0030332)
0.0	0.1	GO:0042285	UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285)
0.0	0.1	GO:0004652	polynucleotide adenylyltransferase activity(GO:0004652)
0.0	0.1	GO:0016907	G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0	0.1	GO:0003986	acetyl-CoA hydrolase activity(GO:0003986)
0.0	0.9	GO:0004197	cysteine-type endopeptidase activity(GO:0004197)
0.0	0.1	GO:0030911	TPR domain binding(GO:0030911)
0.0	0.2	GO:0048531	beta-1,3-galactosyltransferase activity(GO:0048531)
0.0	0.1	GO:0051766	inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440) inositol trisphosphate kinase activity(GO:0051766)
0.0	0.1	GO:0043425	bHLH transcription factor binding(GO:0043425)
0.0	0.1	GO:0003873	6-phosphofructo-2-kinase activity(GO:0003873)
0.0	0.1	GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.0	0.1	GO:0050544	arachidonic acid binding(GO:0050544)
0.0	0.1	GO:0004465	lipoprotein lipase activity(GO:0004465)
0.0	0.1	GO:0004591	oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.0	0.5	GO:0004003	ATP-dependent DNA helicase activity(GO:0004003)
0.0	0.1	GO:0015925	galactosidase activity(GO:0015925)
0.0	0.1	GO:0004826	phenylalanine-tRNA ligase activity(GO:0004826)
0.0	0.2	GO:0005385	zinc ion transmembrane transporter activity(GO:0005385)
0.0	0.1	GO:0047184	1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184)
0.0	0.1	GO:0031434	mitogen-activated protein kinase kinase binding(GO:0031434)
0.0	0.0	GO:0032405	MutLalpha complex binding(GO:0032405)
0.0	0.1	GO:0005143	interleukin-12 receptor binding(GO:0005143)
0.0	0.1	GO:0005087	Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.0	0.0	GO:0000064	L-ornithine transmembrane transporter activity(GO:0000064)
0.0	0.2	GO:0008641	small protein activating enzyme activity(GO:0008641)
0.0	0.1	GO:0070097	delta-catenin binding(GO:0070097)
0.0	0.1	GO:0015379	potassium:chloride symporter activity(GO:0015379)
0.0	0.1	GO:0004427	inorganic diphosphatase activity(GO:0004427)
0.0	0.1	GO:0032452	histone demethylase activity(GO:0032452)
0.0	0.0	GO:0042054	histone methyltransferase activity(GO:0042054)
0.0	0.0	GO:0003953	NAD+ nucleosidase activity(GO:0003953)
0.0	0.1	GO:0015385	sodium:proton antiporter activity(GO:0015385)
0.0	0.0	GO:0042834	peptidoglycan binding(GO:0042834)
0.0	0.0	GO:0008821	crossover junction endodeoxyribonuclease activity(GO:0008821)
0.0	0.0	GO:0034236	protein kinase A catalytic subunit binding(GO:0034236)
0.0	0.3	GO:0005048	signal sequence binding(GO:0005048)
0.0	0.1	GO:0070053	thrombospondin receptor activity(GO:0070053)
0.0	0.1	GO:0005388	calcium-transporting ATPase activity(GO:0005388)
0.0	0.1	GO:0032395	MHC class II receptor activity(GO:0032395)
0.0	0.0	GO:0022897	peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897)
0.0	0.0	GO:0004370	glycerol kinase activity(GO:0004370)
0.0	0.0	GO:0004946	bombesin receptor activity(GO:0004946)
0.0	0.1	GO:0005522	profilin binding(GO:0005522)
0.0	0.1	GO:0017176	phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0	0.1	GO:0005092	GDP-dissociation inhibitor activity(GO:0005092)
0.0	0.0	GO:0004142	diacylglycerol cholinephosphotransferase activity(GO:0004142)
0.0	0.3	GO:0019239	deaminase activity(GO:0019239)
0.0	0.2	GO:0008601	protein phosphatase type 2A regulator activity(GO:0008601)
0.0	0.2	GO:0004889	acetylcholine-activated cation-selective channel activity(GO:0004889)
0.0	0.4	GO:0003755	peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.0	0.0	GO:0042156	obsolete zinc-mediated transcriptional activator activity(GO:0042156)
0.0	0.1	GO:0019534	toxin transporter activity(GO:0019534)
0.0	0.1	GO:0008195	phosphatidate phosphatase activity(GO:0008195)
0.0	0.1	GO:0003857	3-hydroxyacyl-CoA dehydrogenase activity(GO:0003857)
0.0	0.1	GO:0042975	peroxisome proliferator activated receptor binding(GO:0042975)
0.0	0.0	GO:0017056	structural constituent of nuclear pore(GO:0017056)
0.0	0.1	GO:0004904	interferon receptor activity(GO:0004904)
0.0	0.0	GO:0042289	MHC class II protein binding(GO:0042289)
0.0	0.1	GO:0008429	phosphatidylethanolamine binding(GO:0008429)
0.0	0.3	GO:0003823	antigen binding(GO:0003823)
0.0	0.3	GO:0051219	phosphoprotein binding(GO:0051219)
0.0	0.1	GO:0031690	adrenergic receptor binding(GO:0031690)
0.0	0.0	GO:0004060	arylamine N-acetyltransferase activity(GO:0004060)
0.0	0.1	GO:0030955	potassium ion binding(GO:0030955)
0.0	0.2	GO:0016763	transferase activity, transferring pentosyl groups(GO:0016763)
0.0	0.1	GO:0008494	translation activator activity(GO:0008494)
0.0	0.1	GO:0051787	misfolded protein binding(GO:0051787)
0.0	0.4	GO:0018024	histone-lysine N-methyltransferase activity(GO:0018024)
0.0	0.2	GO:0008171	O-methyltransferase activity(GO:0008171)
0.0	0.0	GO:0016997	exo-alpha-sialidase activity(GO:0004308) alpha-sialidase activity(GO:0016997)
0.0	0.2	GO:0016805	dipeptidase activity(GO:0016805)
0.0	0.3	GO:0070003	threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0	0.1	GO:0005251	delayed rectifier potassium channel activity(GO:0005251)
0.0	0.0	GO:0000033	alpha-1,3-mannosyltransferase activity(GO:0000033)
0.0	0.1	GO:0042162	telomeric DNA binding(GO:0042162)
0.0	0.3	GO:0001104	RNA polymerase II transcription cofactor activity(GO:0001104)
0.0	0.1	GO:0050656	3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
0.0	0.3	GO:0016831	carboxy-lyase activity(GO:0016831)
0.0	0.0	GO:0043175	RNA polymerase core enzyme binding(GO:0043175)
0.0	0.1	GO:0016888	endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888)
0.0	0.0	GO:0034190	apolipoprotein receptor binding(GO:0034190)
0.0	0.1	GO:0004017	adenylate kinase activity(GO:0004017)
0.0	0.1	GO:0004568	chitinase activity(GO:0004568)
0.0	0.1	GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656)
0.0	0.1	GO:0005344	oxygen transporter activity(GO:0005344)
0.0	0.0	GO:0019166	trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166)
0.0	0.1	GO:0019894	kinesin binding(GO:0019894)
0.0	0.1	GO:0005375	copper ion transmembrane transporter activity(GO:0005375)
0.0	0.0	GO:0019788	NEDD8 transferase activity(GO:0019788)
0.0	0.0	GO:0019136	deoxynucleoside kinase activity(GO:0019136)
0.0	0.0	GO:0016886	ligase activity, forming phosphoric ester bonds(GO:0016886)
0.0	0.0	GO:0008467	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0	0.0	GO:0032407	guanine/thymine mispair binding(GO:0032137) MutSalpha complex binding(GO:0032407)
0.0	0.1	GO:0004185	serine-type carboxypeptidase activity(GO:0004185)
0.0	0.0	GO:0004366	glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
0.0	0.0	GO:0008073	ornithine decarboxylase inhibitor activity(GO:0008073)
0.0	0.0	GO:0015037	peptide disulfide oxidoreductase activity(GO:0015037)
0.0	0.0	GO:0004127	cytidylate kinase activity(GO:0004127)
0.0	0.0	GO:0090482	vitamin transmembrane transporter activity(GO:0090482)
0.0	0.1	GO:0070402	NADPH binding(GO:0070402)
0.0	0.1	GO:0017049	GTP-Rho binding(GO:0017049)
0.0	0.0	GO:0070492	oligosaccharide binding(GO:0070492)
0.0	0.0	GO:0003987	acetate-CoA ligase activity(GO:0003987)
0.0	0.0	GO:0016312	inositol bisphosphate phosphatase activity(GO:0016312)
0.0	0.1	GO:0001671	ATPase activator activity(GO:0001671)
0.0	0.0	GO:0042806	fucose binding(GO:0042806)
0.0	0.0	GO:0033300	dehydroascorbic acid transporter activity(GO:0033300)
0.0	0.1	GO:0042171	1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) lysophosphatidic acid acyltransferase activity(GO:0042171) lysophospholipid acyltransferase activity(GO:0071617)
0.0	0.0	GO:0034237	protein kinase A regulatory subunit binding(GO:0034237)
0.0	0.1	GO:0003688	DNA replication origin binding(GO:0003688)
0.0	0.0	GO:0004735	pyrroline-5-carboxylate reductase activity(GO:0004735)
0.0	0.1	GO:0017025	TBP-class protein binding(GO:0017025)
0.0	0.0	GO:0004865	protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.0	0.0	GO:0008420	CTD phosphatase activity(GO:0008420)
0.0	0.1	GO:0008409	5'-3' exonuclease activity(GO:0008409)
0.0	0.0	GO:0005384	manganese ion transmembrane transporter activity(GO:0005384)
0.0	0.1	GO:0016274	arginine N-methyltransferase activity(GO:0016273) protein-arginine N-methyltransferase activity(GO:0016274)
0.0	0.0	GO:0004833	tryptophan 2,3-dioxygenase activity(GO:0004833)
0.0	0.0	GO:0047894	flavonol 3-sulfotransferase activity(GO:0047894)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.1	PID CD8 TCR PATHWAY	TCR signaling in naïve CD8+ T cells
0.1	0.6	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0	0.6	PID NFKAPPAB ATYPICAL PATHWAY	Atypical NF-kappaB pathway
0.0	0.4	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0	0.7	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.0	0.6	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
0.0	1.0	PID IL8 CXCR2 PATHWAY	IL8- and CXCR2-mediated signaling events
0.0	0.2	ST PAC1 RECEPTOR PATHWAY	PAC1 Receptor Pathway
0.0	1.2	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0	0.4	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0	0.4	SA B CELL RECEPTOR COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0	0.0	PID PI3KCI AKT PATHWAY	Class I PI3K signaling events mediated by Akt
0.0	0.1	ST INTERFERON GAMMA PATHWAY	Interferon gamma pathway.
0.0	0.2	PID ARF6 PATHWAY	Arf6 signaling events
0.0	1.2	PID AR TF PATHWAY	Regulation of Androgen receptor activity
0.0	0.2	ST JAK STAT PATHWAY	Jak-STAT Pathway
0.0	0.5	PID WNT CANONICAL PATHWAY	Canonical Wnt signaling pathway
0.0	0.3	PID ALK2 PATHWAY	ALK2 signaling events
0.0	0.1	PID ENDOTHELIN PATHWAY	Endothelins
0.0	0.3	SA CASPASE CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0	0.1	PID TRAIL PATHWAY	TRAIL signaling pathway
0.0	0.2	PID NFKAPPAB CANONICAL PATHWAY	Canonical NF-kappaB pathway
0.0	0.1	PID IL5 PATHWAY	IL5-mediated signaling events
0.0	0.7	PID NFAT 3PATHWAY	Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.0	0.4	PID PI3KCI PATHWAY	Class I PI3K signaling events
0.0	0.0	ST G ALPHA S PATHWAY	G alpha s Pathway
0.0	0.3	PID NEPHRIN NEPH1 PATHWAY	Nephrin/Neph1 signaling in the kidney podocyte
0.0	0.1	PID THROMBIN PAR4 PATHWAY	PAR4-mediated thrombin signaling events
0.0	0.2	ST PHOSPHOINOSITIDE 3 KINASE PATHWAY	PI3K Pathway
0.0	0.0	SIG BCR SIGNALING PATHWAY	Members of the BCR signaling pathway
0.0	0.1	PID IL2 PI3K PATHWAY	IL2 signaling events mediated by PI3K
0.0	0.0	PID GLYPICAN 1PATHWAY	Glypican 1 network
0.0	0.5	PID TNF PATHWAY	TNF receptor signaling pathway
0.0	0.2	PID P38 ALPHA BETA PATHWAY	Regulation of p38-alpha and p38-beta
0.0	0.3	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.0	0.1	PID GMCSF PATHWAY	GMCSF-mediated signaling events
0.0	0.4	PID CASPASE PATHWAY	Caspase cascade in apoptosis
0.0	0.1	PID BETA CATENIN DEG PATHWAY	Degradation of beta catenin
0.0	0.2	PID HIF1A PATHWAY	Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0	0.2	PID DNA PK PATHWAY	DNA-PK pathway in nonhomologous end joining
0.0	0.1	PID IL12 STAT4 PATHWAY	IL12 signaling mediated by STAT4
0.0	0.3	PID FCER1 PATHWAY	Fc-epsilon receptor I signaling in mast cells
0.0	0.0	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
0.0	0.1	ST IL 13 PATHWAY	Interleukin 13 (IL-13) Pathway
0.0	0.2	PID RAS PATHWAY	Regulation of Ras family activation
0.0	0.0	ST TUMOR NECROSIS FACTOR PATHWAY	Tumor Necrosis Factor Pathway.
0.0	0.0	PID IL8 CXCR1 PATHWAY	IL8- and CXCR1-mediated signaling events
0.0	0.0	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.0	0.4	PID LKB1 PATHWAY	LKB1 signaling events
0.0	0.1	PID ERBB1 INTERNALIZATION PATHWAY	Internalization of ErbB1
0.0	0.2	PID BCR 5PATHWAY	BCR signaling pathway
0.0	0.1	PID CD40 PATHWAY	CD40/CD40L signaling
0.0	0.1	PID INTEGRIN3 PATHWAY	Beta3 integrin cell surface interactions
0.0	0.1	PID CERAMIDE PATHWAY	Ceramide signaling pathway
0.0	0.1	SIG PIP3 SIGNALING IN B LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes
0.0	0.2	PID INTEGRIN A4B1 PATHWAY	Alpha4 beta1 integrin signaling events
0.0	0.0	ST TYPE I INTERFERON PATHWAY	Type I Interferon (alpha/beta IFN) Pathway
0.0	0.0	ST INTERLEUKIN 4 PATHWAY	Interleukin 4 (IL-4) Pathway
0.0	0.1	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0	0.1	PID ANTHRAX PATHWAY	Cellular roles of Anthrax toxin
0.0	0.1	PID ANGIOPOIETIN RECEPTOR PATHWAY	Angiopoietin receptor Tie2-mediated signaling
0.0	0.0	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
0.0	0.2	PID IL23 PATHWAY	IL23-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.1	REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE	Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.1	1.2	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
0.1	1.3	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.1	0.8	REACTOME N GLYCAN ANTENNAE ELONGATION	Genes involved in N-Glycan antennae elongation
0.1	0.2	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.0	0.3	REACTOME INTEGRATION OF PROVIRUS	Genes involved in Integration of provirus
0.0	0.4	REACTOME ACTIVATION OF RAC	Genes involved in Activation of Rac
0.0	1.1	REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0	0.1	REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1	Genes involved in Autodegradation of the E3 ubiquitin ligase COP1
0.0	0.5	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.0	0.2	REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0	Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
0.0	0.5	REACTOME REGULATION OF IFNG SIGNALING	Genes involved in Regulation of IFNG signaling
0.0	0.1	REACTOME CD28 DEPENDENT VAV1 PATHWAY	Genes involved in CD28 dependent Vav1 pathway
0.0	0.3	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.0	0.2	REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY	Genes involved in Regulation of the Fanconi anemia pathway
0.0	0.1	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
0.0	0.5	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.0	0.6	REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA	Genes involved in Circadian Repression of Expression by REV-ERBA
0.0	0.2	REACTOME IRAK1 RECRUITS IKK COMPLEX	Genes involved in IRAK1 recruits IKK complex
0.0	0.6	REACTOME EFFECTS OF PIP2 HYDROLYSIS	Genes involved in Effects of PIP2 hydrolysis
0.0	0.1	REACTOME PD1 SIGNALING	Genes involved in PD-1 signaling
0.0	0.3	REACTOME P2Y RECEPTORS	Genes involved in P2Y receptors
0.0	0.0	REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK	Genes involved in Negative regulation of the PI3K/AKT network
0.0	0.8	REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE	Genes involved in Synthesis of PIPs at the plasma membrane
0.0	0.4	REACTOME CTNNB1 PHOSPHORYLATION CASCADE	Genes involved in Beta-catenin phosphorylation cascade
0.0	0.1	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING	Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.0	0.4	REACTOME INFLAMMASOMES	Genes involved in Inflammasomes
0.0	0.2	REACTOME SPRY REGULATION OF FGF SIGNALING	Genes involved in Spry regulation of FGF signaling
0.0	0.5	REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS	Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.0	0.3	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade
0.0	0.3	REACTOME IL RECEPTOR SHC SIGNALING	Genes involved in Interleukin receptor SHC signaling
0.0	0.0	REACTOME CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION	Genes involved in Cyclin E associated events during G1/S transition
0.0	0.2	REACTOME P38MAPK EVENTS	Genes involved in p38MAPK events
0.0	0.3	REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE	Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0	0.2	REACTOME ETHANOL OXIDATION	Genes involved in Ethanol oxidation
0.0	0.1	REACTOME IL 6 SIGNALING	Genes involved in Interleukin-6 signaling
0.0	0.0	REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0	0.2	REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0	0.2	REACTOME TRANSPORT OF ORGANIC ANIONS	Genes involved in Transport of organic anions
0.0	0.4	REACTOME TRAF6 MEDIATED NFKB ACTIVATION	Genes involved in TRAF6 mediated NF-kB activation
0.0	0.4	REACTOME G0 AND EARLY G1	Genes involved in G0 and Early G1
0.0	0.1	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION	Genes involved in TRAF6 mediated IRF7 activation
0.0	0.5	REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS	Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
0.0	0.2	REACTOME ARMS MEDIATED ACTIVATION	Genes involved in ARMS-mediated activation
0.0	0.2	REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION	Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0	0.1	REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1	Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.0	0.2	REACTOME SIGNALING BY FGFR1 FUSION MUTANTS	Genes involved in Signaling by FGFR1 fusion mutants
0.0	0.2	REACTOME HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS	Genes involved in Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
0.0	0.5	REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS	Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.0	0.7	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0	0.2	REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY	Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0	0.1	REACTOME IL 3 5 AND GM CSF SIGNALING	Genes involved in Interleukin-3, 5 and GM-CSF signaling
0.0	0.0	REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING	Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0	0.1	REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION	Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.0	0.2	REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE	Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.0	0.3	REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0	0.4	REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS	Genes involved in Post-translational modification: synthesis of GPI-anchored proteins
0.0	0.3	REACTOME INSULIN SYNTHESIS AND PROCESSING	Genes involved in Insulin Synthesis and Processing
0.0	0.7	REACTOME ACTIVATION OF NF KAPPAB IN B CELLS	Genes involved in Activation of NF-kappaB in B Cells
0.0	0.5	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
0.0	0.2	REACTOME NOD1 2 SIGNALING PATHWAY	Genes involved in NOD1/2 Signaling Pathway
0.0	0.2	REACTOME COSTIMULATION BY THE CD28 FAMILY	Genes involved in Costimulation by the CD28 family
0.0	0.2	REACTOME COMMON PATHWAY	Genes involved in Common Pathway
0.0	0.2	REACTOME SYNTHESIS OF PE	Genes involved in Synthesis of PE
0.0	0.0	REACTOME SOS MEDIATED SIGNALLING	Genes involved in SOS-mediated signalling
0.0	0.3	REACTOME CHOLESTEROL BIOSYNTHESIS	Genes involved in Cholesterol biosynthesis
0.0	1.3	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.0	0.1	REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX	Genes involved in Association of licensing factors with the pre-replicative complex
0.0	0.3	REACTOME FORMATION OF INCISION COMPLEX IN GG NER	Genes involved in Formation of incision complex in GG-NER
0.0	0.1	REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA	Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0	0.2	REACTOME METABOLISM OF NON CODING RNA	Genes involved in Metabolism of non-coding RNA
0.0	0.3	REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER	Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.0	0.1	REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP	Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0	0.2	REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION	Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0	0.1	REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI	Genes involved in RIP-mediated NFkB activation via DAI
0.0	0.2	REACTOME GLUCURONIDATION	Genes involved in Glucuronidation
0.0	0.1	REACTOME DOWNSTREAM TCR SIGNALING	Genes involved in Downstream TCR signaling
0.0	0.1	REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	Genes involved in DCC mediated attractive signaling
0.0	0.2	REACTOME CHONDROITIN SULFATE BIOSYNTHESIS	Genes involved in Chondroitin sulfate biosynthesis
0.0	0.1	REACTOME CALNEXIN CALRETICULIN CYCLE	Genes involved in Calnexin/calreticulin cycle
0.0	0.1	REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS	Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0	0.3	REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR	Genes involved in Thromboxane signalling through TP receptor
0.0	0.6	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.0	0.0	REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS	Genes involved in Interactions of Vpr with host cellular proteins
0.0	0.1	REACTOME REGULATION OF HYPOXIA INDUCIBLE FACTOR HIF BY OXYGEN	Genes involved in Regulation of Hypoxia-inducible Factor (HIF) by Oxygen
0.0	0.1	REACTOME ASSEMBLY OF THE PRE REPLICATIVE COMPLEX	Genes involved in Assembly of the pre-replicative complex
0.0	0.1	REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR	Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0	0.1	REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0	0.7	REACTOME MEIOTIC SYNAPSIS	Genes involved in Meiotic Synapsis
0.0	0.1	REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING	Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0	0.2	REACTOME REGULATORY RNA PATHWAYS	Genes involved in Regulatory RNA pathways
0.0	0.0	REACTOME RORA ACTIVATES CIRCADIAN EXPRESSION	Genes involved in RORA Activates Circadian Expression
0.0	0.3	REACTOME AMYLOIDS	Genes involved in Amyloids
0.0	0.1	REACTOME ALPHA LINOLENIC ACID ALA METABOLISM	Genes involved in alpha-linolenic acid (ALA) metabolism
0.0	0.3	REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS	Genes involved in Apoptotic cleavage of cellular proteins
0.0	0.2	REACTOME MITOCHONDRIAL TRNA AMINOACYLATION	Genes involved in Mitochondrial tRNA aminoacylation
0.0	0.0	REACTOME PLATELET SENSITIZATION BY LDL	Genes involved in Platelet sensitization by LDL
0.0	0.1	REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT	Genes involved in Organic cation/anion/zwitterion transport
0.0	0.1	REACTOME PYRIMIDINE CATABOLISM	Genes involved in Pyrimidine catabolism
0.0	0.0	REACTOME ABORTIVE ELONGATION OF HIV1 TRANSCRIPT IN THE ABSENCE OF TAT	Genes involved in Abortive elongation of HIV-1 transcript in the absence of Tat
0.0	0.0	REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS	Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs

Results for POU3F3_POU3F4

Z-value: 1.37

Motif logo

Transcription factors associated with POU3F3_POU3F4

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Activity of the POU3F3_POU3F4 motif across conditions

Conditions sorted by the z-value of the POU3F3_POU3F4 motif activity

Top target CREs of the motif:

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of POU3F3_POU3F4

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: