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ENCODE: H3K4me1 ChIP-Seq of primary human cells

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Results for POU4F1_POU4F3

Z-value: 1.04

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Transcription factors associated with POU4F1_POU4F3

Gene Symbol	Gene ID	Gene Info
POU4F1 Ensembl NCBI GeneCards UniProt	ENSG00000152192.6	POU class 4 homeobox 1
POU4F3 Ensembl NCBI GeneCards UniProt	ENSG00000091010.4	POU class 4 homeobox 3

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
chr13_79199810_79200090	POU4F1	22277	0.153482	0.57	1.1e-01	Click!
chr13_79174218_79174425	POU4F1	3352	0.218427	0.52	1.5e-01	Click!
chr13_79177130_79177294	POU4F1	461	0.806833	0.45	2.2e-01	Click!
chr13_79175692_79175912	POU4F1	1871	0.318458	0.43	2.5e-01	Click!
chr13_79174600_79174773	POU4F1	2987	0.232500	0.41	2.8e-01	Click!
chr5_145717921_145718072	POU4F3	591	0.782112	0.76	1.8e-02	Click!
chr5_145721447_145721598	POU4F3	2935	0.292136	0.73	2.5e-02	Click!
chr5_145725157_145725422	POU4F3	6702	0.225546	0.57	1.1e-01	Click!
chr5_145736188_145736339	POU4F3	17676	0.189534	0.54	1.3e-01	Click!
chr5_145722692_145722843	POU4F3	4180	0.253136	0.44	2.3e-01	Click!

Activity of the POU4F1_POU4F3 motif across conditions

Conditions sorted by the z-value of the POU4F1_POU4F3 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr12_80333454_80333779	0.38	PPP1R12A	protein phosphatase 1, regulatory subunit 12A	4376	0.23
chr13_72186960_72187133	0.37	DACH1	dachshund homolog 1 (Drosophila)	253861	0.02
chr10_28782029_28782414	0.37	WAC-AS1	WAC antisense RNA 1 (head to head)	39062	0.14
chr20_20672099_20672250	0.34	RALGAPA2	Ral GTPase activating protein, alpha subunit 2 (catalytic)	20957	0.24
chr15_75403062_75403317	0.34	ENSG00000252722	.	10818	0.17
chr6_123033360_123033511	0.34	PKIB	protein kinase (cAMP-dependent, catalytic) inhibitor beta	5271	0.25
chr19_41871189_41871344	0.33	B9D2	B9 protein domain 2	1188	0.23
chr20_30638740_30638891	0.33	ENSG00000212571	.	424	0.68
chr1_88927950_88928373	0.33	ENSG00000239504	.	15636	0.29
chr9_90215657_90216062	0.32	DAPK1-IT1	DAPK1 intronic transcript 1 (non-protein coding)	47490	0.16
chr7_75340644_75340809	0.32	HIP1	huntingtin interacting protein 1	27533	0.18
chr20_19056774_19057030	0.32	ENSG00000264669	.	49527	0.16
chr2_129396287_129396587	0.31	ENSG00000238379	.	193665	0.03
chr3_53392628_53392811	0.31	DCP1A	decapping mRNA 1A	11065	0.15
chr20_6888062_6888352	0.31	ENSG00000251833	.	46546	0.2
chr1_185387761_185387912	0.30	ENSG00000252407	.	15540	0.25
chr8_141114049_141114200	0.30	C8orf17	chromosome 8 open reading frame 17	170708	0.04
chr22_37366172_37366323	0.29	LL22NC01-81G9.3		4958	0.13
chr7_106719987_106720297	0.29	CTA-360L10.1		1459	0.48
chr2_208101715_208101973	0.29	AC007879.5		17132	0.2
chr4_185772755_185773053	0.29	ENSG00000266698	.	640	0.72
chr2_238586267_238586492	0.28	LRRFIP1	leucine rich repeat (in FLII) interacting protein 1	14409	0.21
chr1_87241400_87241551	0.28	SH3GLB1	SH3-domain GRB2-like endophilin B1	70897	0.09
chr15_50354775_50354926	0.28	ATP8B4	ATPase, class I, type 8B, member 4	15266	0.24
chr7_40621099_40621486	0.27	AC004988.1		34765	0.24
chr10_75929117_75929268	0.27	ADK	adenosine kinase	7252	0.22
chr6_116950491_116950642	0.27	RSPH4A	radial spoke head 4 homolog A (Chlamydomonas)	12779	0.16
chr1_53264490_53264641	0.27	ENSG00000206627	.	6319	0.17
chr9_127456832_127457191	0.27	ENSG00000207737	.	1022	0.45
chr6_144444768_144445009	0.26	STX11	syntaxin 11	26775	0.18
chr17_8775973_8776124	0.26	PIK3R6	phosphoinositide-3-kinase, regulatory subunit 6	5054	0.22
chr10_98424063_98424439	0.26	PIK3AP1	phosphoinositide-3-kinase adaptor protein 1	5117	0.24
chr11_57123496_57123665	0.26	ENSG00000266018	.	3616	0.12
chr12_14714291_14714442	0.26	RP11-695J4.2		6318	0.16
chr6_131894919_131895070	0.25	ARG1	arginase 1	629	0.75
chr8_68525436_68525618	0.25	ENSG00000221660	.	98340	0.08
chr2_160649569_160649720	0.25	CD302	CD302 molecule	5109	0.26
chr8_13071040_13071223	0.25	ENSG00000200630	.	53444	0.14
chr9_123869033_123869206	0.25	CNTRL	centriolin	11628	0.21
chr5_118354441_118354592	0.24	ENSG00000223179	.	11250	0.16
chr14_70168130_70168306	0.24	SRSF5	serine/arginine-rich splicing factor 5	25399	0.21
chr14_51405417_51405672	0.24	PYGL	phosphorylase, glycogen, liver	5630	0.2
chr7_129710940_129711854	0.24	KLHDC10	kelch domain containing 10	785	0.58
chr9_93557837_93558119	0.24	SYK	spleen tyrosine kinase	6091	0.34
chr3_43306001_43306248	0.23	SNRK	SNF related kinase	21880	0.18
chr14_31879771_31880296	0.23	HEATR5A	HEAT repeat containing 5A	7852	0.16
chr21_39864519_39864670	0.23	ERG	v-ets avian erythroblastosis virus E26 oncogene homolog	5751	0.33
chr17_61823380_61823531	0.23	STRADA	STE20-related kinase adaptor alpha	4125	0.16
chr8_96012667_96012818	0.23	NDUFAF6	NADH dehydrogenase (ubiquinone) complex I, assembly factor 6	19581	0.15
chr20_58563521_58563805	0.23	CDH26	cadherin 26	498	0.81
chr14_77532194_77532345	0.23	CIPC	CLOCK-interacting pacemaker	32171	0.13
chr9_127529464_127529709	0.23	RP11-175D17.3		2816	0.19
chr4_186808544_186808795	0.23	ENSG00000239034	.	58568	0.12
chr10_98958866_98959017	0.23	SLIT1	slit homolog 1 (Drosophila)	13264	0.2
chr3_159671529_159671680	0.23	IL12A	interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)	34933	0.16
chr5_124045646_124045797	0.22	RP11-436H11.2		18803	0.13
chr8_128747584_128747940	0.22	MYC	v-myc avian myelocytomatosis viral oncogene homolog	3	0.99
chr5_139974440_139974703	0.22	ENSG00000200235	.	15319	0.08
chr12_40830849_40831000	0.22	RP11-115F18.1		6725	0.27
chr18_55334626_55334855	0.22	ATP8B1	ATPase, aminophospholipid transporter, class I, type 8B, member 1	21160	0.15
chr2_69085649_69085836	0.22	BMP10	bone morphogenetic protein 10	12907	0.19
chr3_129512470_129512759	0.22	TMCC1	transmembrane and coiled-coil domain family 1	645	0.71
chr2_25500370_25500587	0.22	DNMT3A	DNA (cytosine-5-)-methyltransferase 3 alpha	25298	0.19
chr3_197609809_197610060	0.22	ENSG00000199306	.	11444	0.16
chr9_37990928_37991079	0.22	ENSG00000251745	.	54238	0.13
chr10_50449306_50449457	0.21	C10orf128	chromosome 10 open reading frame 128	52945	0.11
chr6_147092750_147093047	0.21	ADGB	androglobin	1183	0.62
chr12_54754274_54754839	0.21	GPR84	G protein-coupled receptor 84	3702	0.1
chr2_208121057_208121376	0.21	AC007879.5		2240	0.34
chr5_176337499_176337650	0.21	HK3	hexokinase 3 (white cell)	11241	0.21
chr22_37253028_37253224	0.21	NCF4	neutrophil cytosolic factor 4, 40kDa	3904	0.16
chr5_140951045_140951206	0.21	CTD-2024I7.13		13247	0.11
chr19_28994549_28994783	0.21	ENSG00000238514	.	427244	0.01
chr15_50427408_50427756	0.21	ATP8B4	ATPase, class I, type 8B, member 4	16163	0.2
chr13_76079815_76080001	0.21	TBC1D4	TBC1 domain family, member 4	23658	0.17
chr5_173958697_173958848	0.21	MSX2	msh homeobox 2	192764	0.03
chr2_182775079_182775230	0.21	SSFA2	sperm specific antigen 2	78	0.98
chr11_76569492_76569643	0.20	ACER3	alkaline ceramidase 3	2344	0.27
chr4_74884218_74884369	0.20	ENSG00000244194	.	6998	0.13
chr3_182992678_182993398	0.20	B3GNT5	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5	9906	0.2
chr1_249100392_249100606	0.20	SH3BP5L	SH3-binding domain protein 5-like	10773	0.16
chr20_54989104_54989562	0.20	CASS4	Cas scaffolding protein family member 4	2016	0.24
chr10_22658685_22658836	0.20	RP11-301N24.3		8659	0.18
chr13_47390799_47390950	0.20	ESD	esterase D	19507	0.22
chr15_67688351_67688562	0.20	IQCH	IQ motif containing H	23598	0.25
chr4_55234857_55235008	0.20	PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	125190	0.06
chr2_102713679_102713830	0.20	IL1R1	interleukin 1 receptor, type I	7269	0.26
chr18_10213374_10213664	0.20	ENSG00000239031	.	176478	0.03
chr5_79365400_79365551	0.20	CTD-2201I18.1		12752	0.2
chr10_30734331_30734677	0.20	MAP3K8	mitogen-activated protein kinase kinase kinase 8	6753	0.24
chr3_4561411_4561805	0.20	ITPR1	inositol 1,4,5-trisphosphate receptor, type 1	3432	0.29
chr1_185315537_185315948	0.20	IVNS1ABP	influenza virus NS1A binding protein	29281	0.19
chr20_8380540_8381084	0.20	PLCB1-IT1	PLCB1 intronic transcript 1 (non-protein coding)	151440	0.04
chr1_159054009_159054308	0.20	AIM2	absent in melanoma 2	7467	0.19
chr9_81309923_81310074	0.19	PSAT1	phosphoserine aminotransferase 1	397939	0.01
chr2_61272894_61273045	0.19	KIAA1841	KIAA1841	20099	0.15
chr8_82005279_82005608	0.19	PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	18860	0.27
chr21_39808567_39808718	0.19	ERG	v-ets avian erythroblastosis virus E26 oncogene homolog	61703	0.15
chr2_48495874_48496026	0.19	FOXN2	forkhead box N2	45826	0.15
chr20_48321244_48321782	0.19	B4GALT5	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5	8902	0.19
chr3_34825666_34825817	0.19	ENSG00000212442	.	472697	0.01
chr9_129190475_129190626	0.19	ENSG00000252985	.	1378	0.46
chr9_100705659_100705946	0.19	HEMGN	hemogen	1336	0.37
chr1_227508085_227508356	0.19	CDC42BPA	CDC42 binding protein kinase alpha (DMPK-like)	2045	0.46
chr18_7287919_7288079	0.19	ENSG00000212626	.	13152	0.26
chr8_131230071_131230222	0.19	ASAP1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	29142	0.21
chr16_2553328_2553597	0.19	TBC1D24	TBC1 domain family, member 24	5139	0.07
chr14_24746677_24746828	0.19	RABGGTA	Rab geranylgeranyltransferase, alpha subunit	5807	0.07
chr21_39772970_39773167	0.19	ERG	v-ets avian erythroblastosis virus E26 oncogene homolog	97277	0.08
chr1_112017213_112017641	0.19	C1orf162	chromosome 1 open reading frame 162	936	0.39
chr20_31817419_31817570	0.19	AL121901.1	Nasopharyngeal carcinoma-related protein YH1; Uncharacterized protein	5597	0.14
chr15_50347486_50347637	0.19	ATP8B4	ATPase, class I, type 8B, member 4	7977	0.26
chr10_104941768_104942133	0.19	NT5C2	5'-nucleotidase, cytosolic II	7211	0.23
chr20_58559437_58559588	0.19	CDH26	cadherin 26	4649	0.22
chr5_61874227_61874378	0.19	LRRC70	leucine rich repeat containing 70	260	0.59
chr2_207972754_207973110	0.18	ENSG00000253008	.	1865	0.35
chr1_234635615_234635867	0.18	TARBP1	TAR (HIV-1) RNA binding protein 1	20892	0.2
chr4_101986814_101986965	0.18	EMCN-IT1	EMCN intronic transcript 1 (non-protein coding)	251452	0.02
chr8_53380270_53380540	0.18	ST18	suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein)	58040	0.15
chr17_9951156_9951307	0.18	GAS7	growth arrest-specific 7	11167	0.21
chr3_130901409_130901560	0.18	ENSG00000265235	.	5758	0.24
chr3_155364826_155365014	0.18	PLCH1	phospholipase C, eta 1	28908	0.22
chr6_89504864_89505015	0.18	ENSG00000222145	.	80790	0.1
chr9_71581767_71581918	0.18	ENSG00000207000	.	30947	0.18
chr10_111908092_111908243	0.18	MXI1	MAX interactor 1, dimerization protein	59196	0.12
chr5_90349706_90349857	0.18	ENSG00000199643	.	216763	0.02
chr5_10588947_10589098	0.18	ANKRD33B	ankyrin repeat domain 33B	24442	0.18
chr5_76253562_76253713	0.18	CRHBP	corticotropin releasing hormone binding protein	4763	0.2
chr11_118056405_118056625	0.18	SCN2B	sodium channel, voltage-gated, type II, beta subunit	9127	0.15
chr11_60939371_60939609	0.18	VPS37C	vacuolar protein sorting 37 homolog C (S. cerevisiae)	10401	0.15
chr4_80130432_80130713	0.18	LINC01088	long intergenic non-protein coding RNA 1088	2263	0.44
chr2_179888867_179889074	0.18	ENSG00000252000	.	865	0.67
chr2_8529897_8530067	0.18	AC011747.7		285914	0.01
chr1_201690086_201690483	0.18	ENSG00000264802	.	1648	0.27
chr3_57676843_57677703	0.18	DENND6A	DENN/MADD domain containing 6A	1543	0.35
chr4_177240003_177240379	0.18	SPCS3	signal peptidase complex subunit 3 homolog (S. cerevisiae)	924	0.5
chr7_8213797_8213948	0.18	ENSG00000265212	.	19220	0.2
chr14_75235207_75235358	0.18	YLPM1	YLP motif containing 1	5213	0.18
chr1_21484088_21484239	0.17	EIF4G3	eukaryotic translation initiation factor 4 gamma, 3	17067	0.2
chr4_157876674_157876825	0.17	PDGFC	platelet derived growth factor C	15306	0.22
chr1_9688511_9688997	0.17	PIK3CD	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta	23036	0.15
chr14_39342958_39343109	0.17	ENSG00000199285	.	113452	0.07
chr17_28201777_28201939	0.17	ENSG00000239129	.	8166	0.15
chr7_41498494_41498645	0.17	INHBA-AS1	INHBA antisense RNA 1	234945	0.02
chr9_102588366_102588517	0.17	NR4A3	nuclear receptor subfamily 4, group A, member 3	568	0.83
chr17_57075608_57075759	0.17	ENSG00000216168	.	9368	0.15
chr1_206731825_206732218	0.17	RASSF5	Ras association (RalGDS/AF-6) domain family member 5	1528	0.36
chr1_108327675_108328746	0.17	ENSG00000265536	.	9332	0.26
chr10_90174181_90174441	0.17	RNLS	renalase, FAD-dependent amine oxidase	168636	0.03
chr6_135045861_135046160	0.17	ALDH8A1	aldehyde dehydrogenase 8 family, member A1	204289	0.02
chr6_159083295_159083616	0.17	SYTL3	synaptotagmin-like 3	740	0.67
chr9_117387530_117387765	0.17	ENSG00000272241	.	8820	0.16
chr3_137854767_137854935	0.17	A4GNT	alpha-1,4-N-acetylglucosaminyltransferase	3622	0.23
chr19_45714345_45714506	0.17	EXOC3L2	exocyst complex component 3-like 2	20713	0.1
chr17_77802527_77802678	0.17	CBX4	chromobox homolog 4	9078	0.14
chr6_130002763_130003058	0.17	ARHGAP18	Rho GTPase activating protein 18	28460	0.23
chr3_179154656_179154807	0.17	GNB4	guanine nucleotide binding protein (G protein), beta polypeptide 4	14202	0.17
chr16_75052013_75052164	0.17	ZNRF1	zinc and ring finger 1, E3 ubiquitin protein ligase	15893	0.19
chr9_123421951_123422208	0.17	MEGF9	multiple EGF-like-domains 9	54533	0.14
chr5_114963472_114963623	0.17	TICAM2	toll-like receptor adaptor molecule 2	1671	0.23
chr7_107555054_107555205	0.17	DLD	dihydrolipoamide dehydrogenase	23510	0.17
chr2_68594805_68594956	0.17	AC015969.3		2164	0.26
chr2_60760781_60760932	0.17	BCL11A	B-cell CLL/lymphoma 11A (zinc finger protein)	19684	0.21
chr13_53641916_53642067	0.17	OLFM4	olfactomedin 4	39097	0.22
chr9_129291100_129291251	0.17	ENSG00000221768	.	2095	0.34
chrX_37691131_37691282	0.17	DYNLT3	dynein, light chain, Tctex-type 3	15455	0.21
chr1_207739899_207740050	0.17	RP11-78B10.2		13650	0.21
chr21_20813379_20813530	0.17	ENSG00000212609	.	95989	0.1
chr21_15850368_15850646	0.17	SAMSN1	SAM domain, SH3 domain and nuclear localization signals 1	68155	0.11
chr14_86888817_86888968	0.17	RP11-322L20.1	HCG2028865; Uncharacterized protein	483230	0.01
chr13_38973582_38973733	0.17	UFM1	ubiquitin-fold modifier 1	49405	0.19
chr19_33677663_33677957	0.17	LRP3	low density lipoprotein receptor-related protein 3	7680	0.13
chr3_143369680_143369831	0.17	SLC9A9	solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9	197545	0.03
chr1_165823979_165824272	0.17	UCK2	uridine-cytidine kinase 2	27066	0.16
chr5_49942847_49943035	0.17	PARP8	poly (ADP-ribose) polymerase family, member 8	18792	0.3
chr1_149371747_149371939	0.17	FCGR1C	Fc fragment of IgG, high affinity Ic, receptor (CD64), pseudogene	2486	0.21
chr1_114517819_114518204	0.17	OLFML3	olfactomedin-like 3	4052	0.2
chr8_133728950_133729101	0.17	TMEM71	transmembrane protein 71	11207	0.19
chr1_149369816_149369967	0.17	FCGR1C	Fc fragment of IgG, high affinity Ic, receptor (CD64), pseudogene	534	0.71
chr13_59911515_59911795	0.17	ENSG00000239003	.	142549	0.05
chr5_102729544_102729916	0.17	C5orf30	chromosome 5 open reading frame 30	134605	0.05
chr17_76609763_76609914	0.17	DNAH17	dynein, axonemal, heavy chain 17	36362	0.15
chr12_90249897_90250363	0.17	ENSG00000252823	.	102294	0.07
chr5_61789673_61790070	0.17	CKS1B	CDC28 protein kinase regulatory subunit 1B, isoform CRA_b; cDNA, FLJ92030, Homo sapiens CDC28 protein kinase regulatory subunit 1B (CKS1B),mRNA	18438	0.18
chr10_80517232_80517460	0.17	ENSG00000223243	.	6987	0.33
chr20_20241490_20241801	0.17	RP5-1096J16.1		6808	0.21
chr11_36402420_36402673	0.17	PRR5L	proline rich 5 like	3474	0.24
chr14_91435215_91435366	0.16	RPS6KA5	ribosomal protein S6 kinase, 90kDa, polypeptide 5	91188	0.07
chr22_28182987_28183138	0.16	MN1	meningioma (disrupted in balanced translocation) 1	14424	0.25
chr6_20458900_20459055	0.16	ENSG00000222431	.	6273	0.16
chr1_200865216_200865405	0.16	C1orf106	chromosome 1 open reading frame 106	1361	0.42
chr12_42864264_42864415	0.16	RP11-328C8.4		11171	0.15
chr9_110631347_110631608	0.16	ENSG00000222459	.	49782	0.14
chr2_159371668_159371819	0.16	ENSG00000251721	.	18969	0.2
chr11_85846223_85846607	0.16	ENSG00000200877	.	17854	0.2
chr1_21279667_21279818	0.16	EIF4G3	eukaryotic translation initiation factor 4 gamma, 3	11631	0.22
chr4_40586968_40587119	0.16	RBM47	RNA binding motif protein 47	44838	0.16
chr3_151606402_151606587	0.16	SUCNR1	succinate receptor 1	15063	0.22
chr4_140964185_140964473	0.16	RP11-392B6.1		84840	0.09
chr1_38310260_38310411	0.16	MTF1	metal-regulatory transcription factor 1	14957	0.09

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of POU4F1_POU4F3

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0030210	heparin biosynthetic process(GO:0030210)
0.1	0.2	GO:1903224	endodermal cell fate specification(GO:0001714) regulation of endodermal cell fate specification(GO:0042663) regulation of endodermal cell differentiation(GO:1903224)
0.1	0.2	GO:0072216	positive regulation of metanephros development(GO:0072216)
0.1	0.2	GO:2001280	regulation of prostaglandin biosynthetic process(GO:0031392) positive regulation of prostaglandin biosynthetic process(GO:0031394) regulation of unsaturated fatty acid biosynthetic process(GO:2001279) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
0.1	0.2	GO:0002138	retinoic acid biosynthetic process(GO:0002138) diterpenoid biosynthetic process(GO:0016102)
0.1	0.2	GO:0032632	interleukin-3 production(GO:0032632)
0.1	0.1	GO:0007621	negative regulation of female receptivity(GO:0007621)
0.0	0.2	GO:0006610	ribosomal protein import into nucleus(GO:0006610)
0.0	0.2	GO:0045091	regulation of single stranded viral RNA replication via double stranded DNA intermediate(GO:0045091)
0.0	0.1	GO:0032509	endosome transport via multivesicular body sorting pathway(GO:0032509)
0.0	0.2	GO:0048752	semicircular canal morphogenesis(GO:0048752)
0.0	0.1	GO:0060665	regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.0	0.1	GO:0060437	lung growth(GO:0060437)
0.0	0.1	GO:0071731	response to nitric oxide(GO:0071731)
0.0	0.1	GO:0002025	vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure(GO:0002025)
0.0	0.1	GO:0010572	positive regulation of platelet activation(GO:0010572)
0.0	0.2	GO:0016322	neuron remodeling(GO:0016322)
0.0	0.1	GO:0071698	olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.0	0.2	GO:0032493	response to bacterial lipoprotein(GO:0032493) response to bacterial lipopeptide(GO:0070339) cellular response to bacterial lipoprotein(GO:0071220) cellular response to bacterial lipopeptide(GO:0071221)
0.0	0.1	GO:0001865	NK T cell differentiation(GO:0001865) regulation of NK T cell differentiation(GO:0051136) positive regulation of NK T cell differentiation(GO:0051138)
0.0	0.1	GO:0048625	myoblast fate commitment(GO:0048625)
0.0	0.1	GO:0010642	negative regulation of platelet-derived growth factor receptor signaling pathway(GO:0010642)
0.0	0.2	GO:0070373	negative regulation of ERK1 and ERK2 cascade(GO:0070373)
0.0	0.1	GO:0001543	ovarian follicle rupture(GO:0001543)
0.0	0.1	GO:0006422	aspartyl-tRNA aminoacylation(GO:0006422)
0.0	0.1	GO:0055098	response to low-density lipoprotein particle(GO:0055098)
0.0	0.4	GO:0007128	meiotic prophase I(GO:0007128)
0.0	0.2	GO:0030853	negative regulation of granulocyte differentiation(GO:0030853)
0.0	0.1	GO:0008298	intracellular mRNA localization(GO:0008298)
0.0	0.2	GO:0045652	regulation of megakaryocyte differentiation(GO:0045652) regulation of hematopoietic progenitor cell differentiation(GO:1901532)
0.0	0.1	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity(GO:0043552)
0.0	0.1	GO:0045767	obsolete regulation of anti-apoptosis(GO:0045767)
0.0	0.1	GO:0035234	ectopic germ cell programmed cell death(GO:0035234)
0.0	0.1	GO:0006435	threonyl-tRNA aminoacylation(GO:0006435)
0.0	0.1	GO:0070672	response to interleukin-15(GO:0070672)
0.0	0.2	GO:0006527	arginine catabolic process(GO:0006527)
0.0	0.0	GO:0003078	obsolete regulation of natriuresis(GO:0003078)
0.0	0.0	GO:0060059	embryonic retina morphogenesis in camera-type eye(GO:0060059)
0.0	0.0	GO:0051570	negative regulation of histone methylation(GO:0031061) regulation of histone H3-K9 methylation(GO:0051570)
0.0	0.1	GO:0045647	negative regulation of erythrocyte differentiation(GO:0045647)
0.0	0.1	GO:0015959	diadenosine polyphosphate metabolic process(GO:0015959)
0.0	0.1	GO:0001561	fatty acid alpha-oxidation(GO:0001561)
0.0	0.1	GO:0002430	complement receptor mediated signaling pathway(GO:0002430)
0.0	0.1	GO:0043320	natural killer cell activation involved in immune response(GO:0002323) natural killer cell degranulation(GO:0043320)
0.0	0.1	GO:0006686	sphingomyelin biosynthetic process(GO:0006686)
0.0	0.1	GO:0030502	negative regulation of bone mineralization(GO:0030502)
0.0	0.1	GO:1901503	ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
0.0	0.1	GO:0003171	atrioventricular valve development(GO:0003171) atrioventricular valve morphogenesis(GO:0003181)
0.0	0.1	GO:0061318	renal filtration cell differentiation(GO:0061318) glomerular epithelium development(GO:0072010) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.0	0.0	GO:0060737	prostate epithelial cord elongation(GO:0060523) prostate gland morphogenetic growth(GO:0060737)
0.0	0.1	GO:0071436	sodium ion export(GO:0071436)
0.0	0.1	GO:0009235	cobalamin metabolic process(GO:0009235)
0.0	0.1	GO:0010800	positive regulation of peptidyl-threonine phosphorylation(GO:0010800)
0.0	0.1	GO:0032959	inositol trisphosphate biosynthetic process(GO:0032959)
0.0	0.1	GO:0045084	positive regulation of interleukin-12 biosynthetic process(GO:0045084)
0.0	0.1	GO:0034312	diol biosynthetic process(GO:0034312) sphingosine biosynthetic process(GO:0046512)
0.0	0.1	GO:0010887	negative regulation of cholesterol storage(GO:0010887)
0.0	0.1	GO:0018101	protein citrullination(GO:0018101)
0.0	0.1	GO:0019441	tryptophan catabolic process to kynurenine(GO:0019441)
0.0	0.0	GO:0034638	phosphatidylcholine catabolic process(GO:0034638)
0.0	0.1	GO:0051964	negative regulation of synapse assembly(GO:0051964)
0.0	0.1	GO:0019372	lipoxygenase pathway(GO:0019372)
0.0	0.0	GO:0071637	monocyte chemotactic protein-1 production(GO:0071605) regulation of monocyte chemotactic protein-1 production(GO:0071637)
0.0	0.1	GO:0017085	response to insecticide(GO:0017085)
0.0	0.0	GO:0002328	pro-B cell differentiation(GO:0002328)
0.0	0.0	GO:0015864	pyrimidine nucleoside transport(GO:0015864)
0.0	0.0	GO:0009296	obsolete flagellum assembly(GO:0009296)
0.0	0.0	GO:0060584	regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
0.0	0.0	GO:0030948	negative regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030948)
0.0	0.0	GO:0009106	lipoate metabolic process(GO:0009106)
0.0	0.0	GO:0003323	type B pancreatic cell development(GO:0003323)
0.0	0.1	GO:0090136	epithelial cell-cell adhesion(GO:0090136)
0.0	0.0	GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050) positive regulation of sprouting angiogenesis(GO:1903672)
0.0	0.1	GO:0048268	clathrin coat assembly(GO:0048268)
0.0	0.0	GO:0032803	regulation of low-density lipoprotein particle receptor catabolic process(GO:0032803) regulation of receptor catabolic process(GO:2000644)
0.0	0.0	GO:0042574	retinal metabolic process(GO:0042574)
0.0	0.0	GO:1901419	regulation of response to alcohol(GO:1901419)
0.0	0.1	GO:0006907	pinocytosis(GO:0006907)
0.0	0.1	GO:0009215	purine deoxyribonucleoside triphosphate metabolic process(GO:0009215)
0.0	0.0	GO:0046485	ether lipid metabolic process(GO:0046485)
0.0	0.2	GO:0015669	gas transport(GO:0015669)
0.0	0.1	GO:0055009	atrial cardiac muscle tissue development(GO:0003228) atrial cardiac muscle tissue morphogenesis(GO:0055009)
0.0	0.1	GO:0030490	maturation of SSU-rRNA(GO:0030490)
0.0	0.0	GO:0003085	negative regulation of systemic arterial blood pressure(GO:0003085)
0.0	0.0	GO:0046087	cytidine catabolic process(GO:0006216) cytidine deamination(GO:0009972) cytidine metabolic process(GO:0046087)
0.0	0.0	GO:0070682	proteasome regulatory particle assembly(GO:0070682)
0.0	0.1	GO:0003056	regulation of vascular smooth muscle contraction(GO:0003056)
0.0	0.1	GO:0019985	translesion synthesis(GO:0019985)
0.0	0.1	GO:0090116	DNA methylation on cytosine(GO:0032776) C-5 methylation of cytosine(GO:0090116)
0.0	0.1	GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process(GO:0051770)
0.0	0.0	GO:0090195	chemokine secretion(GO:0090195) regulation of chemokine secretion(GO:0090196) positive regulation of chemokine secretion(GO:0090197)
0.0	0.1	GO:0034405	response to fluid shear stress(GO:0034405)
0.0	0.1	GO:0032455	nerve growth factor processing(GO:0032455)
0.0	0.0	GO:1900115	sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.0	0.1	GO:0045006	DNA deamination(GO:0045006)
0.0	0.1	GO:0043302	positive regulation of mast cell activation involved in immune response(GO:0033008) positive regulation of leukocyte degranulation(GO:0043302) positive regulation of mast cell degranulation(GO:0043306)
0.0	0.0	GO:0010936	negative regulation of macrophage cytokine production(GO:0010936)
0.0	0.0	GO:0042726	flavin-containing compound metabolic process(GO:0042726)
0.0	0.0	GO:0046502	uroporphyrinogen III metabolic process(GO:0046502)
0.0	0.1	GO:0045056	transcytosis(GO:0045056)
0.0	0.2	GO:0021846	cell proliferation in forebrain(GO:0021846)
0.0	0.1	GO:0010885	regulation of cholesterol storage(GO:0010885) positive regulation of cholesterol storage(GO:0010886)
0.0	0.0	GO:0007262	STAT protein import into nucleus(GO:0007262)
0.0	0.1	GO:0046835	carbohydrate phosphorylation(GO:0046835)
0.0	0.0	GO:0045650	negative regulation of macrophage differentiation(GO:0045650)
0.0	0.1	GO:0061726	mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726)
0.0	0.0	GO:0032661	interleukin-18 production(GO:0032621) regulation of interleukin-18 production(GO:0032661)
0.0	0.1	GO:0006983	ER overload response(GO:0006983)
0.0	0.1	GO:0051497	negative regulation of stress fiber assembly(GO:0051497)
0.0	0.1	GO:0045116	protein neddylation(GO:0045116)
0.0	0.0	GO:0014832	urinary bladder smooth muscle contraction(GO:0014832)
0.0	0.0	GO:0071277	cellular response to calcium ion(GO:0071277)
0.0	0.0	GO:0021978	telencephalon regionalization(GO:0021978)
0.0	0.1	GO:0051016	barbed-end actin filament capping(GO:0051016)
0.0	0.3	GO:0015914	phospholipid transport(GO:0015914)
0.0	0.0	GO:0010193	response to ozone(GO:0010193)
0.0	0.0	GO:0001821	histamine secretion(GO:0001821)
0.0	0.0	GO:0070244	negative regulation of thymocyte apoptotic process(GO:0070244)
0.0	0.0	GO:0060528	secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.0	0.0	GO:0009200	deoxyribonucleoside triphosphate metabolic process(GO:0009200)
0.0	0.1	GO:0042953	lipoprotein transport(GO:0042953) lipoprotein localization(GO:0044872)
0.0	0.0	GO:0045292	mRNA cis splicing, via spliceosome(GO:0045292)
0.0	0.1	GO:0000301	retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.0	0.0	GO:0006556	S-adenosylmethionine biosynthetic process(GO:0006556)
0.0	0.0	GO:0002283	neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312)
0.0	0.1	GO:0030174	regulation of DNA-dependent DNA replication initiation(GO:0030174)
0.0	0.0	GO:0031536	positive regulation of exit from mitosis(GO:0031536)
0.0	0.1	GO:0035116	embryonic hindlimb morphogenesis(GO:0035116)
0.0	0.0	GO:0016265	obsolete death(GO:0016265)
0.0	0.0	GO:0017000	antibiotic metabolic process(GO:0016999) antibiotic biosynthetic process(GO:0017000)
0.0	0.0	GO:0043162	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.0	0.1	GO:0034331	cell junction maintenance(GO:0034331) cell-cell junction maintenance(GO:0045217)
0.0	0.0	GO:0060219	camera-type eye photoreceptor cell differentiation(GO:0060219)
0.0	0.0	GO:0007144	female meiosis I(GO:0007144)
0.0	0.0	GO:0034653	diterpenoid catabolic process(GO:0016103) terpenoid catabolic process(GO:0016115) retinoic acid catabolic process(GO:0034653)
0.0	0.0	GO:0021780	spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) oligodendrocyte cell fate specification(GO:0021778) glial cell fate specification(GO:0021780)
0.0	0.0	GO:0043116	negative regulation of vascular permeability(GO:0043116)
0.0	0.0	GO:0008215	spermine metabolic process(GO:0008215)
0.0	0.0	GO:0070172	positive regulation of tooth mineralization(GO:0070172)
0.0	0.0	GO:0046005	positive regulation of circadian sleep/wake cycle, REM sleep(GO:0046005)
0.0	0.0	GO:0019255	glucose 1-phosphate metabolic process(GO:0019255)
0.0	0.0	GO:2000178	negative regulation of neuroblast proliferation(GO:0007406) negative regulation of neural precursor cell proliferation(GO:2000178)
0.0	0.0	GO:0006572	tyrosine catabolic process(GO:0006572)
0.0	0.0	GO:0050651	dermatan sulfate proteoglycan biosynthetic process(GO:0050651)

Gene overrepresentation in cellular component category:

Total log-likelihood	Term	Description
0.2	GO:0031088	platelet dense granule membrane(GO:0031088)
0.3	GO:0016281	eukaryotic translation initiation factor 4F complex(GO:0016281)
0.1	GO:0042629	mast cell granule(GO:0042629)
0.3	GO:0042581	specific granule(GO:0042581)
0.1	GO:0000306	extrinsic component of vacuolar membrane(GO:0000306) extrinsic component of endosome membrane(GO:0031313)
0.1	GO:0043218	compact myelin(GO:0043218)
0.1	GO:0031092	platelet alpha granule membrane(GO:0031092)
0.1	GO:0005899	insulin receptor complex(GO:0005899)
0.1	GO:0044298	neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.1	GO:0005787	signal peptidase complex(GO:0005787)
0.2	GO:0043020	NADPH oxidase complex(GO:0043020)
0.1	GO:0000164	protein phosphatase type 1 complex(GO:0000164)
0.1	GO:0045254	pyruvate dehydrogenase complex(GO:0045254)
0.1	GO:0070083	clathrin-sculpted monoamine transport vesicle(GO:0070081) clathrin-sculpted monoamine transport vesicle membrane(GO:0070083)
0.1	GO:0031588	nucleotide-activated protein kinase complex(GO:0031588)
0.1	GO:0030061	mitochondrial crista(GO:0030061)
0.0	GO:0008540	proteasome regulatory particle, base subcomplex(GO:0008540)
0.0	GO:1990316	ATG1/ULK1 kinase complex(GO:1990316)
0.1	GO:0000145	exocyst(GO:0000145)
0.0	GO:0005672	transcription factor TFIIA complex(GO:0005672)
0.0	GO:0071062	alphav-beta3 integrin-vitronectin complex(GO:0071062)
0.0	GO:0005639	integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.1	GO:0031082	BLOC complex(GO:0031082) BLOC-1 complex(GO:0031083)
0.3	GO:0031907	peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0001098	basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.1	0.4	GO:0004908	interleukin-1 receptor activity(GO:0004908)
0.0	0.1	GO:0050544	arachidonic acid binding(GO:0050544)
0.0	0.2	GO:0048027	mRNA 5'-UTR binding(GO:0048027)
0.0	0.1	GO:0045236	CXCR chemokine receptor binding(GO:0045236)
0.0	0.1	GO:0070324	thyroid hormone binding(GO:0070324)
0.0	0.3	GO:0000339	RNA cap binding(GO:0000339)
0.0	0.2	GO:0019911	structural constituent of myelin sheath(GO:0019911)
0.0	0.1	GO:0016842	amidine-lyase activity(GO:0016842)
0.0	0.1	GO:0004939	beta-adrenergic receptor activity(GO:0004939)
0.0	0.1	GO:0001758	retinal dehydrogenase activity(GO:0001758)
0.0	0.1	GO:0031957	very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0	0.3	GO:0019864	IgG binding(GO:0019864)
0.0	0.1	GO:0019834	phospholipase A2 inhibitor activity(GO:0019834)
0.0	0.1	GO:0019763	immunoglobulin receptor activity(GO:0019763)
0.0	0.2	GO:0004887	thyroid hormone receptor activity(GO:0004887)
0.0	0.1	GO:0050693	LBD domain binding(GO:0050693)
0.0	0.1	GO:0004815	aspartate-tRNA ligase activity(GO:0004815)
0.0	0.1	GO:0019788	NEDD8 transferase activity(GO:0019788)
0.0	0.1	GO:0005030	neurotrophin receptor activity(GO:0005030)
0.0	0.1	GO:0047238	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.0	0.1	GO:0070579	methylcytosine dioxygenase activity(GO:0070579)
0.0	0.1	GO:0004829	threonine-tRNA ligase activity(GO:0004829)
0.0	0.1	GO:0047035	testosterone dehydrogenase (NAD+) activity(GO:0047035)
0.0	0.1	GO:0033130	acetylcholine receptor binding(GO:0033130)
0.0	0.1	GO:0004833	tryptophan 2,3-dioxygenase activity(GO:0004833)
0.0	0.3	GO:0004012	phospholipid-translocating ATPase activity(GO:0004012)
0.0	0.1	GO:0004185	serine-type carboxypeptidase activity(GO:0004185)
0.0	0.1	GO:0004652	polynucleotide adenylyltransferase activity(GO:0004652)
0.0	0.1	GO:0008184	glycogen phosphorylase activity(GO:0008184)
0.0	0.0	GO:0005350	pyrimidine nucleobase transmembrane transporter activity(GO:0005350)
0.0	0.1	GO:0008486	diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486)
0.0	0.1	GO:0004875	complement receptor activity(GO:0004875)
0.0	0.1	GO:0001784	phosphotyrosine binding(GO:0001784)
0.0	0.2	GO:0016813	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.0	0.1	GO:0030676	Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0	0.1	GO:0005275	amine transmembrane transporter activity(GO:0005275)
0.0	0.1	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0	0.0	GO:0050265	RNA uridylyltransferase activity(GO:0050265)
0.0	0.1	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0	0.1	GO:0051637	obsolete Gram-positive bacterial cell surface binding(GO:0051637)
0.0	0.0	GO:0070644	vitamin D response element binding(GO:0070644)
0.0	0.0	GO:0034056	estrogen response element binding(GO:0034056)
0.0	0.0	GO:0002162	dystroglycan binding(GO:0002162)
0.0	0.0	GO:0071723	lipopeptide binding(GO:0071723)
0.0	0.0	GO:0070548	L-glutamine aminotransferase activity(GO:0070548)
0.0	0.1	GO:0015016	[heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0	0.2	GO:0070888	E-box binding(GO:0070888)
0.0	0.1	GO:0004597	peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.0	0.1	GO:0008504	monoamine transmembrane transporter activity(GO:0008504)
0.0	0.0	GO:0047756	chondroitin 4-sulfotransferase activity(GO:0047756)
0.0	0.1	GO:0016175	superoxide-generating NADPH oxidase activity(GO:0016175)
0.0	0.0	GO:0042808	obsolete neuronal Cdc2-like kinase binding(GO:0042808)
0.0	0.0	GO:0004144	diacylglycerol O-acyltransferase activity(GO:0004144)
0.0	0.1	GO:0004859	phospholipase inhibitor activity(GO:0004859)
0.0	0.1	GO:0016520	growth hormone-releasing hormone receptor activity(GO:0016520)
0.0	0.0	GO:0042978	ornithine decarboxylase activator activity(GO:0042978)
0.0	0.1	GO:0003810	protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0	0.4	GO:0005544	calcium-dependent phospholipid binding(GO:0005544)
0.0	0.1	GO:0004862	cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0	0.1	GO:0003886	DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0	0.1	GO:0043208	glycosphingolipid binding(GO:0043208)
0.0	0.1	GO:0004075	biotin carboxylase activity(GO:0004075)
0.0	0.0	GO:0016972	thiol oxidase activity(GO:0016972)
0.0	0.1	GO:0004340	glucokinase activity(GO:0004340)
0.0	0.1	GO:0008157	protein phosphatase 1 binding(GO:0008157)
0.0	0.1	GO:0005432	calcium:sodium antiporter activity(GO:0005432)
0.0	0.0	GO:0070891	lipoteichoic acid binding(GO:0070891)
0.0	0.0	GO:0050542	icosanoid binding(GO:0050542) fatty acid derivative binding(GO:1901567)
0.0	0.1	GO:0003997	acyl-CoA oxidase activity(GO:0003997)
0.0	0.0	GO:0071553	uridine nucleotide receptor activity(GO:0015065) G-protein coupled pyrimidinergic nucleotide receptor activity(GO:0071553)
0.0	0.1	GO:0008190	eukaryotic initiation factor 4E binding(GO:0008190)
0.0	0.0	GO:0016724	ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0	0.0	GO:0004514	nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514)
0.0	0.1	GO:0030276	clathrin binding(GO:0030276)
0.0	0.1	GO:0033612	receptor serine/threonine kinase binding(GO:0033612)
0.0	0.1	GO:0043015	gamma-tubulin binding(GO:0043015)
0.0	0.0	GO:0004465	lipoprotein lipase activity(GO:0004465)
0.0	0.2	GO:0043498	obsolete cell surface binding(GO:0043498)
0.0	0.0	GO:0033765	steroid dehydrogenase activity, acting on the CH-CH group of donors(GO:0033765)
0.0	0.2	GO:0031683	G-protein beta/gamma-subunit complex binding(GO:0031683)
0.0	0.1	GO:0015385	sodium:proton antiporter activity(GO:0015385)
0.0	0.1	GO:0004467	long-chain fatty acid-CoA ligase activity(GO:0004467)
0.0	0.2	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.1	ST G ALPHA I PATHWAY	G alpha i Pathway
0.0	PID SYNDECAN 1 PATHWAY	Syndecan-1-mediated signaling events
0.1	ST PAC1 RECEPTOR PATHWAY	PAC1 Receptor Pathway
0.1	PID CD40 PATHWAY	CD40/CD40L signaling
0.1	SA B CELL RECEPTOR COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.5	PID IL8 CXCR2 PATHWAY	IL8- and CXCR2-mediated signaling events
0.0	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0	PID HDAC CLASSII PATHWAY	Signaling events mediated by HDAC Class II
0.4	SIG PIP3 SIGNALING IN B LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes
0.1	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
0.0	PID PI3KCI AKT PATHWAY	Class I PI3K signaling events mediated by Akt
0.0	ST PHOSPHOINOSITIDE 3 KINASE PATHWAY	PI3K Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.1	REACTOME OPIOID SIGNALLING	Genes involved in Opioid Signalling
0.0	0.2	REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0	0.5	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.0	0.1	REACTOME EGFR DOWNREGULATION	Genes involved in EGFR downregulation
0.0	0.2	REACTOME TIE2 SIGNALING	Genes involved in Tie2 Signaling
0.0	0.1	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.0	0.2	REACTOME N GLYCAN ANTENNAE ELONGATION	Genes involved in N-Glycan antennae elongation
0.0	0.0	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.0	0.1	REACTOME ROLE OF DCC IN REGULATING APOPTOSIS	Genes involved in Role of DCC in regulating apoptosis
0.0	0.1	REACTOME DSCAM INTERACTIONS	Genes involved in DSCAM interactions
0.0	0.1	REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL	Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.0	0.1	REACTOME ERKS ARE INACTIVATED	Genes involved in ERKs are inactivated
0.0	0.1	REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION	Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0	0.3	REACTOME GPVI MEDIATED ACTIVATION CASCADE	Genes involved in GPVI-mediated activation cascade

Results for POU4F1_POU4F3

Z-value: 1.04

Motif logo

Transcription factors associated with POU4F1_POU4F3

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Activity of the POU4F1_POU4F3 motif across conditions

Conditions sorted by the z-value of the POU4F1_POU4F3 motif activity

Top target CREs of the motif:

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of POU4F1_POU4F3

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: