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ENCODE: H3K4me1 ChIP-Seq of primary human cells
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Results for POU4F2

Z-value: 0.79

Motif logo

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Transcription factors associated with POU4F2

Gene Symbol Gene ID Gene Info
POU4F2
ENSG00000151615.3 POU class 4 homeobox 2

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr4_147559724_147559875POU4F22460.7863390.551.3e-01Click!
chr4_147559444_147559682POU4F24820.6561620.472.0e-01Click!
chr4_147558738_147558956POU4F211980.4236910.166.7e-01Click!
chr4_147558452_147558603POU4F215180.3697890.107.9e-01Click!

Activity of the POU4F2 motif across conditions

Conditions sorted by the z-value of the POU4F2 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr7_50425191_50425522 0.38 IKZF1
 IKAROS family zinc finger 1 (Ikaros)
 58111
 0.13
chr13_41546420_41546779 0.33 ELF1
 E74-like factor 1 (ets domain transcription factor)
 9819
 0.2
chr5_75745118_75745695 0.28 IQGAP2
 IQ motif containing GTPase activating protein 2
 45157
 0.18
chr13_32616590_32616779 0.28 FRY-AS1
 FRY antisense RNA 1
 10908
 0.22
chr5_66503273_66503424 0.28 CD180
 CD180 molecule
 10721
 0.29
chr14_91844279_91844530 0.27 CCDC88C
 coiled-coil domain containing 88C
 39286
 0.15
chr12_46611375_46611659 0.27 SLC38A1
 solute carrier family 38, member 1
 49967
 0.18
chr5_64919668_64919819 0.27 TRIM23
 tripartite motif containing 23
 380
 0.59
chrX_48803684_48803856 0.26 OTUD5
 OTU domain containing 5
 10681
 0.09
chr12_92796420_92796828 0.26 RP11-693J15.4
18683
 0.18
chr8_41851376_41851636 0.26 KAT6A
 K(lysine) acetyltransferase 6A
 35625
 0.16
chr10_102989164_102989315 0.25 LBX1-AS1
 LBX1 antisense RNA 1 (head to head)
 112
 0.75
chr14_70111444_70111741 0.25 KIAA0247
 KIAA0247
 33279
 0.18
chr22_22959542_22959693 0.24 IGLV3-30
 immunoglobulin lambda variable 3-30 (pseudogene)
 1425
 0.16
chrX_65207829_65207989 0.24 RP6-159A1.3
11684
 0.22
chr1_155910079_155910230 0.23 RXFP4
 relaxin/insulin-like family peptide receptor 4
 1326
 0.24
chr2_48115307_48115553 0.23 FBXO11
 F-box protein 11
 428
 0.87
chr2_24011570_24011828 0.23 ATAD2B
 ATPase family, AAA domain containing 2B
 31026
 0.21
chrX_118822856_118823258 0.23 SEPT6
 septin 6
 3735
 0.22
chr1_226913884_226914070 0.23 ITPKB
 inositol-trisphosphate 3-kinase B
 11182
 0.22
chr12_104613249_104613462 0.22 TXNRD1
 thioredoxin reductase 1
 3796
 0.26
chr2_109582380_109582745 0.22 EDAR
 ectodysplasin A receptor
 23163
 0.25
chr12_4269171_4269375 0.22 CCND2
 cyclin D2
 113665
 0.06
chr5_156695529_156695722 0.22 CYFIP2
 cytoplasmic FMR1 interacting protein 2
 737
 0.55
chr3_5234609_5235124 0.21 EDEM1
 ER degradation enhancer, mannosidase alpha-like 1
 4832
 0.17
chr12_14524656_14525040 0.21 ATF7IP
 activating transcription factor 7 interacting protein
 4541
 0.28
chr13_42962332_42962715 0.21 AKAP11
 A kinase (PRKA) anchor protein 11
 116234
 0.06
chr1_236161357_236161691 0.21 ENSG00000252822
 .
 62453
 0.1
chr19_39686992_39687200 0.21 NCCRP1
 non-specific cytotoxic cell receptor protein 1 homolog (zebrafish)
 505
 0.69
chr3_172313351_172313574 0.21 AC007919.2
 HCG1787166; PRO1163; Uncharacterized protein
 48021
 0.13
chr17_14103623_14103847 0.21 AC005224.2
10070
 0.2
chr14_61814414_61814719 0.21 PRKCH
 protein kinase C, eta
 43
 0.98
chr6_35623682_35623888 0.21 ENSG00000212579
 .
 4190
 0.17
chr6_45562756_45562907 0.21 ENSG00000252738
 .
 51010
 0.18
chr3_150353533_150353862 0.20 SELT
 Selenoprotein T
 32574
 0.14
chr11_60250640_60250791 0.20 MS4A12
 membrane-spanning 4-domains, subfamily A, member 12
 9536
 0.16
chr5_56024755_56025049 0.20 MAP3K1
 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
 86499
 0.08
chr1_209946191_209946467 0.20 TRAF3IP3
 TRAF3 interacting protein 3
 4369
 0.16
chr1_109188369_109188646 0.20 HENMT1
 HEN1 methyltransferase homolog 1 (Arabidopsis)
 15170
 0.19
chr4_38531154_38531351 0.20 RP11-617D20.1
94944
 0.08
chr14_98641364_98641616 0.20 ENSG00000222066
 .
 156597
 0.04
chr11_104824137_104824288 0.19 CASP4
 caspase 4, apoptosis-related cysteine peptidase
 3213
 0.26
chr3_46321372_46321650 0.19 CCR3
 chemokine (C-C motif) receptor 3
 14892
 0.2
chr1_10010013_10010180 0.19 ENSG00000202415
 .
 2720
 0.15
chr17_57906699_57906989 0.19 ENSG00000199004
 .
 11783
 0.14
chr21_15895977_15896201 0.19 SAMSN1
 SAM domain, SH3 domain and nuclear localization signals 1
 22573
 0.22
chr2_234242106_234242479 0.19 SAG
 S-antigen; retina and pineal gland (arrestin)
 14098
 0.13
chr16_84769322_84769473 0.19 USP10
 ubiquitin specific peptidase 10
 32474
 0.16
chr16_50203548_50203935 0.19 PAPD5
 PAP associated domain containing 5
 15962
 0.16
chr11_36707129_36707280 0.19 RAG2
 recombination activating gene 2
 87418
 0.09
chr9_20760833_20760984 0.19 ENSG00000202189
 .
 26018
 0.18
chr15_34616601_34616752 0.19 SLC12A6
 solute carrier family 12 (potassium/chloride transporter), member 6
 5696
 0.13
chr3_135909805_135909961 0.18 MSL2
 male-specific lethal 2 homolog (Drosophila)
 3513
 0.32
chrX_77577768_77577919 0.18 CYSLTR1
 cysteinyl leukotriene receptor 1
 5137
 0.34
chr5_110576250_110576470 0.18 CAMK4
 calcium/calmodulin-dependent protein kinase IV
 16576
 0.2
chr19_16378207_16378501 0.18 CTD-2562J15.6
26032
 0.13
chr13_74434481_74434632 0.18 KLF12
 Kruppel-like factor 12
 134630
 0.06
chr14_103947022_103947173 0.18 MARK3
 MAP/microtubule affinity-regulating kinase 3
 5636
 0.14
chr8_8780588_8780739 0.18 ENSG00000200713
 .
 27340
 0.15
chr12_111495461_111495881 0.18 ENSG00000221259
 .
 16101
 0.22
chr1_197730766_197730996 0.18 RP11-448G4.4
4432
 0.25
chr22_20226344_20226543 0.18 RTN4R
 reticulon 4 receptor
 4764
 0.15
chr17_27226385_27226542 0.17 RP11-20B24.4
1664
 0.15
chr14_97204795_97205013 0.17 VRK1
 vaccinia related kinase 1
 58737
 0.14
chr2_210012742_210012893 0.17 ENSG00000202164
 .
 227429
 0.02
chr5_130728393_130728544 0.17 CDC42SE2
 CDC42 small effector 2
 7169
 0.31
chr14_99730566_99730874 0.17 AL109767.1
1435
 0.45
chr11_128600475_128600823 0.17 FLI1
 Fli-1 proto-oncogene, ETS transcription factor
 34036
 0.15
chr2_202077121_202077490 0.17 CASP8
 caspase 8, apoptosis-related cysteine peptidase
 20861
 0.15
chr6_89858004_89858155 0.17 PM20D2
 peptidase M20 domain containing 2
 2310
 0.27
chr11_70212191_70212342 0.17 AP000487.6
2792
 0.17
chr12_873798_873949 0.17 WNK1
 WNK lysine deficient protein kinase 1
 11141
 0.2
chr20_22669194_22669345 0.17 ENSG00000265151
 .
 44670
 0.19
chr5_10446969_10447137 0.17 ROPN1L
 rhophilin associated tail protein 1-like
 5065
 0.16
chr10_76593578_76593729 0.17 KAT6B
 K(lysine) acetyltransferase 6B
 4805
 0.33
chr13_41176451_41176709 0.17 FOXO1
 forkhead box O1
 64154
 0.11
chr19_39636621_39636772 0.17 CTC-218B8.3
9593
 0.13
chr10_22899839_22899998 0.17 PIP4K2A
 phosphatidylinositol-5-phosphate 4-kinase, type II, alpha
 19276
 0.27
chr14_55350751_55350902 0.17 ENSG00000265432
 .
 5915
 0.2
chr9_79006052_79006266 0.17 RFK
 riboflavin kinase
 2889
 0.34
chr14_96984501_96984733 0.16 PAPOLA
 poly(A) polymerase alpha
 9162
 0.19
chr6_35642615_35642766 0.16 ENSG00000265527
 .
 10124
 0.13
chr3_196351016_196351281 0.16 LINC01063
 long intergenic non-protein coding RNA 1063
 8310
 0.13
chr22_42795773_42795924 0.16 NFAM1
 NFAT activating protein with ITAM motif 1
 32553
 0.15
chr2_190457819_190458046 0.16 SLC40A1
 solute carrier family 40 (iron-regulated transporter), member 1
 9448
 0.23
chr3_59438465_59438651 0.16 C3orf67
 chromosome 3 open reading frame 67
 402748
 0.01
chr15_52802125_52802276 0.16 MYO5A
 myosin VA (heavy chain 12, myoxin)
 18838
 0.2
chr4_2543068_2543219 0.16 RNF4
 ring finger protein 4
 51605
 0.11
chr1_153915425_153915874 0.16 DENND4B
 DENN/MADD domain containing 4B
 917
 0.37
chr7_150381782_150381933 0.16 GIMAP2
 GTPase, IMAP family member 2
 931
 0.55
chr3_186743797_186744281 0.16 ST6GAL1
 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
 768
 0.72
chr19_35635680_35635831 0.16 FXYD7
 FXYD domain containing ion transport regulator 7
 1572
 0.21
chr8_131018111_131018262 0.16 ENSG00000253043
 .
 1339
 0.38
chr19_47439033_47439191 0.16 ENSG00000252071
 .
 12434
 0.16
chr11_19141347_19141498 0.16 ZDHHC13
 zinc finger, DHHC-type containing 13
 2730
 0.3
chr12_12627541_12627708 0.16 DUSP16
 dual specificity phosphatase 16
 46435
 0.15
chrX_146996931_146997212 0.16 FMR1
 fragile X mental retardation 1
 3373
 0.19
chr7_41670352_41670503 0.16 INHBA-AS1
 INHBA antisense RNA 1
 63087
 0.13
chr21_34756882_34757061 0.16 IFNGR2
 interferon gamma receptor 2 (interferon gamma transducer 1)
 18231
 0.17
chr2_166185054_166185205 0.16 SCN2A
 sodium channel, voltage-gated, type II, alpha subunit
 32846
 0.22
chr4_147101931_147102201 0.16 LSM6
 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
 5185
 0.24
chr9_95639818_95640106 0.16 ZNF484
 zinc finger protein 484
 256
 0.91
chr11_118079214_118079365 0.16 AMICA1
 adhesion molecule, interacts with CXADR antigen 1
 4311
 0.17
chr2_197129691_197129922 0.16 AC020571.3
4649
 0.23
chr6_34859204_34859355 0.16 ANKS1A
 ankyrin repeat and sterile alpha motif domain containing 1A
 2199
 0.29
chrX_78363655_78363841 0.16 GPR174
 G protein-coupled receptor 174
 62721
 0.15
chr3_71752260_71752853 0.16 EIF4E3
 eukaryotic translation initiation factor 4E family member 3
 21970
 0.2
chr18_23807897_23808083 0.16 TAF4B
 TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
 1540
 0.45
chr14_102229413_102229564 0.16 PPP2R5C
 protein phosphatase 2, regulatory subunit B', gamma
 223
 0.93
chr20_58563521_58563805 0.15 CDH26
 cadherin 26
 498
 0.81
chr5_109042881_109043032 0.15 ENSG00000202512
 .
 7421
 0.21
chr10_76927238_76927389 0.15 ENSG00000263626
 .
 17403
 0.17
chr3_182514507_182514741 0.15 ATP11B
 ATPase, class VI, type 11B
 3333
 0.27
chr20_52371356_52371791 0.15 ENSG00000238468
 .
 86276
 0.09
chr1_198688446_198688597 0.15 RP11-553K8.5
52331
 0.15
chr2_205941650_205941801 0.15 PARD3B
 par-3 family cell polarity regulator beta
 531002
 0.0
chr17_72457353_72457898 0.15 CD300A
 CD300a molecule
 4930
 0.16
chr1_185564690_185564852 0.15 ENSG00000207108
 .
 34889
 0.18
chr4_78777778_78777929 0.15 MRPL1
 mitochondrial ribosomal protein L1
 5821
 0.28
chr11_6253593_6253744 0.15 FAM160A2
 family with sequence similarity 160, member A2
 2178
 0.18
chr2_148052557_148052708 0.15 ENSG00000238860
 .
 28907
 0.24
chr15_59069056_59069207 0.15 FAM63B
 family with sequence similarity 63, member B
 5570
 0.16
chr12_32635854_32636150 0.15 FGD4
 FYVE, RhoGEF and PH domain containing 4
 2904
 0.29
chr6_135517535_135517686 0.15 MYB-AS1
 MYB antisense RNA 1
 477
 0.8
chr9_95484035_95484186 0.15 BICD2
 bicaudal D homolog 2 (Drosophila)
 42984
 0.13
chr18_54540471_54540622 0.15 RP11-383D22.1
655
 0.75
chr3_59870371_59870601 0.15 NPCDR1
 nasopharyngeal carcinoma, down-regulated 1
 87097
 0.11
chr14_98670195_98670346 0.15 ENSG00000222066
 .
 127817
 0.06
chr1_200987046_200987749 0.15 KIF21B
 kinesin family member 21B
 5139
 0.21
chr10_5336359_5336594 0.15 AKR1C7P
 aldo-keto reductase family 1, member C7, pseudogene
 6043
 0.22
chr3_56822315_56822473 0.15 ARHGEF3
 Rho guanine nucleotide exchange factor (GEF) 3
 12709
 0.27
chrX_136135361_136135512 0.15 GPR101
 G protein-coupled receptor 101
 21603
 0.23
chr6_52229427_52229615 0.15 PAQR8
 progestin and adipoQ receptor family member VIII
 2277
 0.36
chr3_71388678_71388829 0.14 FOXP1
 forkhead box P1
 34842
 0.2
chrX_123345247_123345413 0.14 ENSG00000252693
 .
 13737
 0.27
chr10_112576652_112576803 0.14 PDCD4
 programmed cell death 4 (neoplastic transformation inhibitor)
 54838
 0.09
chr4_40239897_40240335 0.14 RHOH
 ras homolog family member H
 38152
 0.16
chr6_136888334_136888570 0.14 MAP7
 microtubule-associated protein 7
 16495
 0.15
chr15_31609527_31609678 0.14 KLF13
 Kruppel-like factor 13
 9456
 0.3
chr2_207423946_207424097 0.14 ADAM23
 ADAM metallopeptidase domain 23
 35538
 0.16
chr8_61708850_61709103 0.14 RP11-33I11.2
13189
 0.27
chr17_72460689_72460840 0.14 CD300A
 CD300a molecule
 1791
 0.28
chr6_510989_511207 0.14 RP1-20B11.2
13073
 0.28
chr7_150200142_150200645 0.14 GIMAP7
 GTPase, IMAP family member 7
 11525
 0.18
chr20_57828211_57828498 0.14 EDN3
 endothelin 3
 47128
 0.15
chr1_225626130_225626281 0.14 LBR
 lamin B receptor
 9578
 0.19
chrX_53439376_53439559 0.14 SMC1A
 structural maintenance of chromosomes 1A
 9500
 0.13
chr1_40237254_40237405 0.14 OXCT2
 3-oxoacid CoA transferase 2
 309
 0.85
chr8_128505801_128505952 0.14 CASC8
 cancer susceptibility candidate 8 (non-protein coding)
 11492
 0.29
chr8_74782842_74782993 0.14 UBE2W
 ubiquitin-conjugating enzyme E2W (putative)
 8143
 0.22
chr13_42969980_42970150 0.14 AKAP11
 A kinase (PRKA) anchor protein 11
 123776
 0.06
chr14_61911773_61912242 0.14 PRKCH
 protein kinase C, eta
 2731
 0.34
chr1_118161397_118161548 0.14 FAM46C
 family with sequence similarity 46, member C
 12916
 0.21
chr17_73394655_73394806 0.14 RP11-16C1.1
4526
 0.1
chr20_30791417_30791568 0.14 PLAGL2
 pleiomorphic adenoma gene-like 2
 4102
 0.17
chr13_108958916_108959067 0.14 ENSG00000223177
 .
 5312
 0.26
chr9_102847485_102847636 0.14 ERP44
 endoplasmic reticulum protein 44
 13762
 0.18
chr6_15481650_15481973 0.14 DTNBP1
 dystrobrevin binding protein 1
 66782
 0.12
chr10_124899981_124900411 0.13 HMX3
 H6 family homeobox 3
 4718
 0.19
chr3_4631294_4631445 0.13 ITPR1
 inositol 1,4,5-trisphosphate receptor, type 1
 73193
 0.11
chr1_89949288_89949439 0.13 LRRC8B
 leucine rich repeat containing 8 family, member B
 41032
 0.16
chr4_13617345_13617663 0.13 BOD1L1
 biorientation of chromosomes in cell division 1-like 1
 11843
 0.2
chr7_37355725_37356299 0.13 ELMO1
 engulfment and cell motility 1
 26355
 0.19
chr8_82015786_82015967 0.13 PAG1
 phosphoprotein associated with glycosphingolipid microdomains 1
 8427
 0.3
chr3_107694284_107694711 0.13 CD47
 CD47 molecule
 82711
 0.11
chr1_87370261_87370412 0.13 SEP15
 Homo sapiens 15 kDa selenoprotein (SEP15), transcript variant 2, mRNA.
 9473
 0.19
chr2_43402387_43402951 0.13 ZFP36L2
 ZFP36 ring finger protein-like 2
 51079
 0.14
chr2_182178684_182178846 0.13 ENSG00000266705
 .
 8386
 0.31
chr3_10431850_10432181 0.13 ENSG00000216135
 .
 4231
 0.19
chr2_61193206_61193983 0.13 ENSG00000222251
 .
 32293
 0.14
chr3_160223250_160223401 0.13 ENSG00000238741
 .
 9699
 0.15
chr1_243875301_243875452 0.13 RP11-370K11.1
28747
 0.22
chr11_14721501_14721718 0.13 PDE3B
 phosphodiesterase 3B, cGMP-inhibited
 56232
 0.14
chr4_41867501_41867667 0.13 TMEM33
 transmembrane protein 33
 69553
 0.1
chr1_110755959_110756150 0.13 KCNC4
 potassium voltage-gated channel, Shaw-related subfamily, member 4
 1932
 0.23
chr9_78818081_78818316 0.13 PCSK5
 proprotein convertase subtilisin/kexin type 5
 14643
 0.3
chr8_82100250_82100582 0.13 PAG1
 phosphoprotein associated with glycosphingolipid microdomains 1
 76113
 0.1
chr6_129773905_129774056 0.13 ENSG00000252554
 .
 15855
 0.24
chr14_60239379_60239530 0.13 RTN1
 reticulon 1
 98230
 0.07
chr21_17124088_17124239 0.13 USP25
 ubiquitin specific peptidase 25
 21667
 0.21
chr3_59904477_59904972 0.13 NPCDR1
 nasopharyngeal carcinoma, down-regulated 1
 52859
 0.19
chrX_129293967_129294118 0.13 AIFM1
 apoptosis-inducing factor, mitochondrion-associated, 1
 5596
 0.21
chr1_153946990_153947141 0.13 JTB
 jumping translocation breakpoint
 2805
 0.11
chr13_48759162_48759578 0.13 ITM2B
 integral membrane protein 2B
 47924
 0.15
chr8_6587293_6587616 0.13 ENSG00000266038
 .
 15231
 0.18
chr12_68425662_68425813 0.13 IFNG-AS1
 IFNG antisense RNA 1
 42428
 0.2
chr13_28191870_28192051 0.13 LNX2
 ligand of numb-protein X 2
 2581
 0.28
chr8_2166897_2167149 0.13 MYOM2
 myomesin 2
 173839
 0.03
chr10_30786899_30787172 0.13 ENSG00000239744
 .
 57798
 0.12
chr17_39494241_39494487 0.13 KRT33A
 keratin 33A
 12700
 0.08
chr1_117552373_117552688 0.13 CD101
 CD101 molecule
 8096
 0.17
chr6_36560550_36560701 0.13 SRSF3
 serine/arginine-rich splicing factor 3
 1520
 0.33
chr3_30644677_30644865 0.13 TGFBR2
 transforming growth factor, beta receptor II (70/80kDa)
 3223
 0.38
chrX_153401681_153401915 0.13 OPN1LW
 opsin 1 (cone pigments), long-wave-sensitive
 7900
 0.14
chr5_102170913_102171092 0.13 PAM
 peptidylglycine alpha-amidating monooxygenase
 29239
 0.26
chr12_123367328_123367490 0.13 VPS37B
 vacuolar protein sorting 37 homolog B (S. cerevisiae)
 7297
 0.17
chr11_10478818_10479214 0.13 AMPD3
 adenosine monophosphate deaminase 3
 1283
 0.47
chr12_123918544_123918695 0.13 RILPL2
 Rab interacting lysosomal protein-like 2
 2645
 0.22
chr3_169943043_169943194 0.13 PRKCI
 protein kinase C, iota
 2965
 0.25
chr1_40500409_40500629 0.13 CAP1
 CAP, adenylate cyclase-associated protein 1 (yeast)
 5386
 0.21

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of POU4F2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.1 GO:0048003 antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003)
0.0 0.1 GO:0009405 pathogenesis(GO:0009405)
0.0 0.1 GO:0046642 negative regulation of alpha-beta T cell proliferation(GO:0046642)
0.0 0.1 GO:0051138 NK T cell differentiation(GO:0001865) regulation of NK T cell differentiation(GO:0051136) positive regulation of NK T cell differentiation(GO:0051138)
0.0 0.2 GO:0035246 peptidyl-arginine N-methylation(GO:0035246)
0.0 0.1 GO:0001711 endodermal cell fate commitment(GO:0001711) endodermal cell differentiation(GO:0035987)
0.0 0.2 GO:0050857 positive regulation of antigen receptor-mediated signaling pathway(GO:0050857)
0.0 0.1 GO:0001672 regulation of chromatin assembly or disassembly(GO:0001672)
0.0 0.1 GO:0046952 ketone body catabolic process(GO:0046952)
0.0 0.1 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0 0.1 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.0 0.1 GO:0046033 AMP metabolic process(GO:0046033)
0.0 0.1 GO:0002430 complement receptor mediated signaling pathway(GO:0002430)
0.0 0.0 GO:0001766 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.0 0.1 GO:0010956 negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137)
0.0 0.1 GO:0045059 positive thymic T cell selection(GO:0045059)
0.0 0.1 GO:0060662 tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662)
0.0 0.1 GO:0034625 fatty acid elongation, monounsaturated fatty acid(GO:0034625)
0.0 0.1 GO:0042726 flavin-containing compound metabolic process(GO:0042726)
0.0 0.2 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.0 0.1 GO:0015917 aminophospholipid transport(GO:0015917)
0.0 0.1 GO:0009048 dosage compensation by inactivation of X chromosome(GO:0009048)
0.0 0.1 GO:0007172 signal complex assembly(GO:0007172)
0.0 0.1 GO:0045759 negative regulation of action potential(GO:0045759)
0.0 0.1 GO:0033152 immunoglobulin V(D)J recombination(GO:0033152)
0.0 0.1 GO:0033169 histone H3-K9 demethylation(GO:0033169)
0.0 0.1 GO:0061384 heart trabecula formation(GO:0060347) heart trabecula morphogenesis(GO:0061384)
0.0 0.1 GO:0021898 commitment of multipotent stem cells to neuronal lineage in forebrain(GO:0021898)
0.0 0.1 GO:0072531 pyrimidine-containing compound transmembrane transport(GO:0072531)
0.0 0.0 GO:0060633 negative regulation of transcription initiation from RNA polymerase II promoter(GO:0060633) negative regulation of DNA-templated transcription, initiation(GO:2000143)
0.0 0.1 GO:0060123 regulation of growth hormone secretion(GO:0060123)
0.0 0.1 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.0 0.1 GO:0043312 neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312)
0.0 0.1 GO:0043984 histone H4-K16 acetylation(GO:0043984)
0.0 0.0 GO:0032212 positive regulation of telomere maintenance via telomerase(GO:0032212) positive regulation of telomere maintenance via telomere lengthening(GO:1904358)
0.0 0.0 GO:0001821 histamine secretion(GO:0001821)
0.0 0.0 GO:0045722 positive regulation of gluconeogenesis(GO:0045722)
0.0 0.1 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.0 0.1 GO:0031936 negative regulation of chromatin silencing(GO:0031936)
0.0 0.0 GO:0060789 hair follicle placode formation(GO:0060789)
0.0 0.1 GO:0022027 interkinetic nuclear migration(GO:0022027)
0.0 0.1 GO:0006422 aspartyl-tRNA aminoacylation(GO:0006422)
0.0 0.1 GO:0019987 obsolete negative regulation of anti-apoptosis(GO:0019987)
0.0 0.1 GO:0050856 regulation of T cell receptor signaling pathway(GO:0050856)
0.0 0.0 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
0.0 0.1 GO:0034088 maintenance of sister chromatid cohesion(GO:0034086) maintenance of mitotic sister chromatid cohesion(GO:0034088)
0.0 0.1 GO:0003100 regulation of systemic arterial blood pressure by endothelin(GO:0003100)
0.0 0.0 GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling(GO:0010882)
0.0 0.0 GO:0001705 ectoderm formation(GO:0001705)
0.0 0.1 GO:0006465 signal peptide processing(GO:0006465)
0.0 0.0 GO:0003056 regulation of vascular smooth muscle contraction(GO:0003056)
0.0 0.1 GO:0007256 activation of JNKK activity(GO:0007256)
0.0 0.0 GO:0060972 left/right pattern formation(GO:0060972)
0.0 0.0 GO:0018076 N-terminal peptidyl-lysine acetylation(GO:0018076)
0.0 0.1 GO:0034755 iron ion transmembrane transport(GO:0034755)
0.0 0.1 GO:0000301 retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.0 0.1 GO:0006482 protein demethylation(GO:0006482) protein dealkylation(GO:0008214)
0.0 0.0 GO:0045793 positive regulation of cell size(GO:0045793)
0.0 0.0 GO:0045591 positive regulation of regulatory T cell differentiation(GO:0045591)
0.0 0.0 GO:0006154 adenosine catabolic process(GO:0006154)
0.0 0.0 GO:0060585 regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
0.0 0.0 GO:0031946 regulation of glucocorticoid biosynthetic process(GO:0031946)
0.0 0.1 GO:0060080 inhibitory postsynaptic potential(GO:0060080)
0.0 0.0 GO:0035162 embryonic hemopoiesis(GO:0035162)
0.0 0.2 GO:0015804 neutral amino acid transport(GO:0015804)
0.0 0.2 GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771)
0.0 0.1 GO:0005513 detection of calcium ion(GO:0005513)
0.0 0.1 GO:0015671 oxygen transport(GO:0015671)
0.0 0.0 GO:0045767 obsolete regulation of anti-apoptosis(GO:0045767)
0.0 0.0 GO:0010508 positive regulation of autophagy(GO:0010508)
0.0 0.0 GO:0010940 positive regulation of necrotic cell death(GO:0010940)
0.0 0.0 GO:0071436 sodium ion export(GO:0071436)
0.0 0.0 GO:0042091 interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.0 0.1 GO:0008608 attachment of spindle microtubules to kinetochore(GO:0008608)
0.0 0.2 GO:0050853 B cell receptor signaling pathway(GO:0050853)
0.0 0.1 GO:0018345 protein palmitoylation(GO:0018345)
0.0 0.0 GO:0010447 response to acidic pH(GO:0010447)
0.0 0.0 GO:0071699 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.0 0.0 GO:0010459 negative regulation of heart rate(GO:0010459)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0 0.2 GO:0031264 death-inducing signaling complex(GO:0031264)
0.0 0.1 GO:0072487 MSL complex(GO:0072487)
0.0 0.2 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.1 GO:0000137 Golgi cis cisterna(GO:0000137)
0.0 0.1 GO:0044453 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.0 0.0 GO:0071942 XPC complex(GO:0071942)
0.0 0.1 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 0.1 GO:0042598 obsolete vesicular fraction(GO:0042598)
0.0 0.0 GO:0000942 condensed nuclear chromosome outer kinetochore(GO:0000942)
0.0 0.2 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.0 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.0 0.1 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.0 0.1 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.0 GO:0005826 actomyosin contractile ring(GO:0005826)
0.0 0.0 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0047623 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0 0.1 GO:0008545 JUN kinase kinase activity(GO:0008545)
0.0 0.2 GO:0016274 arginine N-methyltransferase activity(GO:0016273) protein-arginine N-methyltransferase activity(GO:0016274)
0.0 0.1 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0 0.1 GO:0042910 xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.0 0.1 GO:0004311 farnesyltranstransferase activity(GO:0004311)
0.0 0.1 GO:0047756 chondroitin 4-sulfotransferase activity(GO:0047756)
0.0 0.1 GO:0070087 chromo shadow domain binding(GO:0070087)
0.0 0.1 GO:0004875 complement receptor activity(GO:0004875)
0.0 0.2 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.1 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.0 0.0 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0 0.1 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.1 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0 0.1 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.0 0.1 GO:0004949 cannabinoid receptor activity(GO:0004949)
0.0 0.1 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.0 0.0 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0 0.2 GO:0005283 sodium:amino acid symporter activity(GO:0005283)
0.0 0.1 GO:0070579 methylcytosine dioxygenase activity(GO:0070579)
0.0 0.2 GO:0004697 protein kinase C activity(GO:0004697)
0.0 0.1 GO:0004974 leukotriene receptor activity(GO:0004974)
0.0 0.1 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 0.1 GO:0036002 pre-mRNA binding(GO:0036002)
0.0 0.1 GO:0034593 phosphatidylinositol bisphosphate phosphatase activity(GO:0034593)
0.0 0.0 GO:0019834 phospholipase A2 inhibitor activity(GO:0019834)
0.0 0.0 GO:0031708 bombesin receptor binding(GO:0031705) endothelin B receptor binding(GO:0031708)
0.0 0.0 GO:0016842 amidine-lyase activity(GO:0016842)
0.0 0.1 GO:0004791 thioredoxin-disulfide reductase activity(GO:0004791)
0.0 0.3 GO:0008601 protein phosphatase type 2A regulator activity(GO:0008601)
0.0 0.1 GO:0047238 glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.0 0.0 GO:0030375 thyroid hormone receptor coactivator activity(GO:0030375)
0.0 0.0 GO:0003829 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0003829)
0.0 0.1 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.0 0.1 GO:0030371 translation repressor activity(GO:0030371)
0.0 0.1 GO:0031702 type 1 angiotensin receptor binding(GO:0031702)
0.0 0.1 GO:0004815 aspartate-tRNA ligase activity(GO:0004815)
0.0 0.0 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.0 0.1 GO:0050733 RS domain binding(GO:0050733)
0.0 0.1 GO:0004908 interleukin-1 receptor activity(GO:0004908)
0.0 0.0 GO:0017159 pantetheine hydrolase activity(GO:0017159)
0.0 0.0 GO:0001758 retinal dehydrogenase activity(GO:0001758)
0.0 0.1 GO:0052813 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.0 0.1 GO:0009922 fatty acid elongase activity(GO:0009922)
0.0 0.1 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 0.3 GO:0019003 GDP binding(GO:0019003)
0.0 0.0 GO:0003726 double-stranded RNA adenosine deaminase activity(GO:0003726)
0.0 0.0 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0 0.0 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0 0.0 GO:0004515 nicotinamide-nucleotide adenylyltransferase activity(GO:0000309) nicotinate-nucleotide adenylyltransferase activity(GO:0004515)
0.0 0.1 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 0.0 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.0 0.1 GO:0016493 C-C chemokine receptor activity(GO:0016493)
0.0 0.0 GO:0003986 acetyl-CoA hydrolase activity(GO:0003986)
0.0 0.1 GO:0015520 tetracycline:proton antiporter activity(GO:0015520)
0.0 0.1 GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440) inositol trisphosphate kinase activity(GO:0051766)
0.0 0.1 GO:0015924 mannosyl-oligosaccharide mannosidase activity(GO:0015924)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
0.0 0.2 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.1 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 0.2 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 0.2 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.0 0.4 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 0.2 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.0 0.5 PID NFAT 3PATHWAY Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.0 0.5 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.0 0.1 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.0 0.1 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.0 REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0 0.0 REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 Genes involved in Autodegradation of the E3 ubiquitin ligase COP1
0.0 0.2 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 0.2 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.0 0.1 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.0 0.2 REACTOME CTNNB1 PHOSPHORYLATION CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.0 0.0 REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
0.0 0.0 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.0 0.2 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0 0.1 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
0.0 0.1 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.0 0.1 REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR Genes involved in Thromboxane signalling through TP receptor
0.0 0.0 REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.0 0.2 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.0 0.0 REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0 0.2 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling