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ENCODE: H3K4me1 ChIP-Seq of primary human cells
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Results for POU6F1

Z-value: 1.04

Motif logo

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Transcription factors associated with POU6F1

Gene Symbol Gene ID Gene Info
POU6F1
ENSG00000184271.11 POU class 6 homeobox 1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr12_51612102_51612253POU6F17000.581175-0.761.7e-02Click!
chr12_51580556_51580707POU6F1101870.123099-0.693.9e-02Click!
chr12_51610080_51610231POU6F113220.3356650.694.0e-02Click!
chr12_51612401_51612910POU6F111780.372640-0.636.9e-02Click!
chr12_51610871_51611203POU6F14400.756378-0.618.2e-02Click!

Activity of the POU6F1 motif across conditions

Conditions sorted by the z-value of the POU6F1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr4_170638169_170638320 0.56 CLCN3
 chloride channel, voltage-sensitive 3
 21462
 0.2
chr17_54218727_54219172 0.46 ANKFN1
 ankyrin-repeat and fibronectin type III domain containing 1
 11887
 0.29
chr12_28716405_28716556 0.43 CCDC91
 coiled-coil domain containing 91
 14483
 0.27
chr1_52435800_52436083 0.43 ENSG00000200839
 .
 3141
 0.18
chr3_39031899_39032050 0.42 ENSG00000206708
 .
 35504
 0.14
chr5_139049687_139050600 0.42 CXXC5
 CXXC finger protein 5
 4878
 0.24
chr5_35626957_35627108 0.42 ENSG00000238441
 .
 6094
 0.25
chr13_66381692_66381843 0.42 ENSG00000221685
 .
 56538
 0.17
chr5_41796126_41796277 0.41 OXCT1
 3-oxoacid CoA transferase 1
 1516
 0.51
chr6_125541820_125541971 0.40 TPD52L1
 tumor protein D52-like 1
 904
 0.71
chr8_121680676_121680965 0.39 RP11-713M15.1
92673
 0.09
chr5_15691172_15691323 0.36 FBXL7
 F-box and leucine-rich repeat protein 7
 75156
 0.11
chr8_122843360_122843511 0.36 HAS2-AS1
 HAS2 antisense RNA 1
 189759
 0.03
chr2_200205268_200205419 0.34 RP11-486F17.1
15310
 0.28
chr8_129527596_129527747 0.34 ENSG00000201782
 .
 294921
 0.01
chr2_68025793_68025944 0.33 C1D
 C1D nuclear receptor corepressor
 264246
 0.02
chr18_46270227_46270648 0.33 RP11-426J5.2
55647
 0.13
chr3_148722415_148722820 0.33 GYG1
 glycogenin 1
 12459
 0.19
chr2_33466958_33467109 0.32 LTBP1
 latent transforming growth factor beta binding protein 1
 1696
 0.46
chr6_148845405_148845556 0.32 ENSG00000223322
 .
 104
 0.98
chr11_119438895_119439046 0.32 RP11-196E1.3
40165
 0.15
chr6_113253230_113253381 0.32 ENSG00000201386
 .
 39390
 0.23
chr11_129920633_129920906 0.32 AP003041.2
 Uncharacterized protein
 16067
 0.19
chr3_52683246_52683397 0.32 PBRM1
 polybromo 1
 29262
 0.08
chr7_81227564_81227715 0.32 HGF
 hepatocyte growth factor (hepapoietin A; scatter factor)
 164673
 0.04
chr19_47418746_47418897 0.32 ARHGAP35
 Rho GTPase activating protein 35
 3112
 0.23
chr13_75465674_75465825 0.31 ENSG00000206812
 .
 217975
 0.02
chr8_59979328_59979517 0.31 RP11-25K19.1
52177
 0.13
chr8_119778166_119778317 0.30 SAMD12
 sterile alpha motif domain containing 12
 144007
 0.05
chr5_146749657_146749808 0.30 DPYSL3
 dihydropyrimidinase-like 3
 31433
 0.19
chr3_64448583_64448734 0.30 PRICKLE2
 prickle homolog 2 (Drosophila)
 17506
 0.23
chr10_733389_733540 0.30 DIP2C
 DIP2 disco-interacting protein 2 homolog C (Drosophila)
 2142
 0.29
chr9_113941044_113941228 0.30 ENSG00000212409
 .
 81443
 0.1
chr13_74701587_74701980 0.30 KLF12
 Kruppel-like factor 12
 6611
 0.34
chr11_70170303_70170454 0.30 CTA-797E19.2
2937
 0.16
chr5_52151940_52152091 0.30 CTD-2288O8.1
68155
 0.1
chr4_113437546_113438608 0.30 NEUROG2
 neurogenin 2
 749
 0.58
chr14_65552013_65552503 0.29 RP11-840I19.3
3506
 0.19
chr13_33249941_33250092 0.29 PDS5B
 PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)
 82291
 0.09
chr15_49530289_49530440 0.29 ENSG00000243338
 .
 38973
 0.14
chr15_70920408_70920559 0.29 UACA
 uveal autoantigen with coiled-coil domains and ankyrin repeats
 74137
 0.12
chr18_21470429_21470580 0.29 ENSG00000221389
 .
 3666
 0.25
chr3_125401874_125402052 0.29 ENSG00000266857
 .
 7137
 0.22
chr9_3342035_3342186 0.29 RFX3
 regulatory factor X, 3 (influences HLA class II expression)
 4654
 0.35
chr8_19489778_19489959 0.29 CSGALNACT1
 chondroitin sulfate N-acetylgalactosaminyltransferase 1
 29862
 0.25
chr10_62109936_62110087 0.29 ANK3
 ankyrin 3, node of Ranvier (ankyrin G)
 39477
 0.23
chr14_69220818_69221003 0.29 ENSG00000207089
 .
 18165
 0.2
chr3_149808903_149809054 0.29 RP11-167H9.4
5252
 0.22
chr2_185461548_185461699 0.29 ZNF804A
 zinc finger protein 804A
 1470
 0.6
chr3_129311849_129312381 0.29 ENSG00000239437
 .
 1923
 0.28
chr13_22272696_22272847 0.28 FGF9
 fibroblast growth factor 9
 27249
 0.22
chr14_61557835_61557986 0.28 SLC38A6
 solute carrier family 38, member 6
 48042
 0.15
chr12_109042760_109042911 0.28 CORO1C
 coronin, actin binding protein, 1C
 3286
 0.17
chr4_114609792_114609943 0.28 CAMK2D
 calcium/calmodulin-dependent protein kinase II delta
 72357
 0.13
chr8_25779248_25779399 0.28 EBF2
 early B-cell factor 2
 33891
 0.24
chr1_183106798_183106949 0.28 RP11-181K3.4
3544
 0.27
chr15_77747199_77747484 0.28 HMG20A
 high mobility group 20A
 3218
 0.31
chr3_159740833_159741097 0.28 LINC01100
 long intergenic non-protein coding RNA 1100
 7154
 0.2
chr12_68841133_68841474 0.28 MDM1
 Mdm1 nuclear protein homolog (mouse)
 115142
 0.06
chr3_46023429_46023580 0.28 FYCO1
 FYVE and coiled-coil domain containing 1
 2983
 0.25
chr7_71564289_71564440 0.28 CALN1
 calneuron 1
 179424
 0.03
chr1_109920976_109921127 0.28 SORT1
 sortilin 1
 14928
 0.15
chr7_77130046_77130330 0.28 PTPN12
 protein tyrosine phosphatase, non-receptor type 12
 36404
 0.19
chr9_140215104_140215809 0.28 NRARP
 NOTCH-regulated ankyrin repeat protein
 18753
 0.09
chr13_115076948_115077099 0.27 CHAMP1
 chromosome alignment maintaining phosphoprotein 1
 2965
 0.23
chr10_22725352_22725818 0.27 RP11-301N24.3
75484
 0.09
chr7_98475291_98476046 0.27 TRRAP
 transformation/transcription domain-associated protein
 112
 0.95
chr3_43769942_43770093 0.27 ABHD5
 abhydrolase domain containing 5
 16818
 0.24
chr6_106612627_106612780 0.27 RP1-134E15.3
64688
 0.11
chr5_100764513_100764664 0.27 ENSG00000264318
 .
 152946
 0.05
chr15_91007004_91007155 0.27 RP11-154B12.3
65966
 0.08
chr2_225410033_225410184 0.27 CUL3
 cullin 3
 17908
 0.29
chr7_132617410_132617561 0.27 AC009518.8
102032
 0.07
chr8_126588731_126588882 0.26 ENSG00000266452
 .
 131999
 0.05
chr13_34110896_34111047 0.26 STARD13
 StAR-related lipid transfer (START) domain containing 13
 186204
 0.03
chr15_96885439_96885590 0.26 ENSG00000222651
 .
 9024
 0.16
chr1_21318917_21319257 0.26 ENSG00000221808
 .
 4162
 0.26
chr1_98377242_98377756 0.26 DPYD
 dihydropyrimidine dehydrogenase
 9054
 0.31
chr1_203516920_203517071 0.26 OPTC
 opticin
 51897
 0.13
chr1_54557402_54557553 0.26 AL161915.1
 Uncharacterized protein
 12491
 0.14
chr5_98057263_98057414 0.26 RGMB
 repulsive guidance molecule family member b
 47661
 0.15
chr13_111053690_111053841 0.26 ENSG00000238629
 .
 12787
 0.23
chr8_18707372_18707523 0.26 PSD3
 pleckstrin and Sec7 domain containing 3
 4437
 0.29
chr1_82386697_82386848 0.26 LPHN2
 latrophilin 2
 21881
 0.29
chr12_1740008_1740328 0.26 WNT5B
 wingless-type MMTV integration site family, member 5B
 190
 0.95
chr2_190538393_190538544 0.26 ANKAR
 ankyrin and armadillo repeat containing
 2243
 0.28
chr18_66106660_66106811 0.26 TMX3
 thioredoxin-related transmembrane protein 3
 275559
 0.02
chr12_52080077_52080228 0.26 SCN8A
 sodium channel, voltage gated, type VIII, alpha subunit
 55
 0.98
chr2_60711834_60711985 0.26 AC009970.1
10912
 0.25
chr21_38512491_38512642 0.26 TTC3
 tetratricopeptide repeat domain 3
 4294
 0.2
chr2_40573390_40573541 0.26 SLC8A1
 solute carrier family 8 (sodium/calcium exchanger), member 1
 83955
 0.1
chr5_34523547_34523698 0.26 RAI14
 retinoic acid induced 14
 132720
 0.05
chr10_112689960_112690181 0.25 SHOC2
 soc-2 suppressor of clear homolog (C. elegans)
 10765
 0.14
chr11_88136410_88136561 0.25 CTSC
 cathepsin C
 65530
 0.13
chr10_72965207_72965358 0.25 UNC5B
 unc-5 homolog B (C. elegans)
 7045
 0.19
chr22_43324968_43325242 0.25 PACSIN2
 protein kinase C and casein kinase substrate in neurons 2
 16774
 0.21
chr4_20489405_20489556 0.25 ENSG00000207732
 .
 40418
 0.18
chr11_45103871_45104025 0.25 PRDM11
 PR domain containing 11
 11616
 0.28
chr3_29228707_29228858 0.25 RBMS3
 RNA binding motif, single stranded interacting protein 3
 93691
 0.09
chr2_62899326_62899477 0.25 EHBP1
 EH domain binding protein 1
 1585
 0.42
chr10_80870080_80870231 0.25 ZMIZ1
 zinc finger, MIZ-type containing 1
 41363
 0.18
chr9_21081966_21082494 0.25 IFNB1
 interferon, beta 1, fibroblast
 4287
 0.21
chr2_133435941_133436092 0.25 LYPD1
 LY6/PLAUR domain containing 1
 6864
 0.25
chr8_62658133_62658284 0.25 ENSG00000264408
 .
 30861
 0.2
chr8_116430587_116430872 0.25 TRPS1
 trichorhinophalangeal syndrome I
 73719
 0.12
chr1_101073343_101073642 0.25 GPR88
 G protein-coupled receptor 88
 69799
 0.11
chr8_118889653_118889804 0.25 EXT1
 exostosin glycosyltransferase 1
 232925
 0.02
chr9_16218365_16218516 0.25 C9orf92
 chromosome 9 open reading frame 92
 2543
 0.44
chr3_16483097_16483616 0.25 RFTN1
 raftlin, lipid raft linker 1
 41016
 0.17
chr14_90788424_90788710 0.25 NRDE2
 NRDE-2, necessary for RNA interference, domain containing
 9712
 0.21
chr7_150940874_150941828 0.25 RP4-548D19.3
3866
 0.11
chr7_47579797_47580043 0.25 TNS3
 tensin 3
 721
 0.8
chr20_43120077_43120228 0.24 SERINC3
 serine incorporator 3
 13380
 0.12
chr11_35267852_35268003 0.24 SLC1A2
 solute carrier family 1 (glial high affinity glutamate transporter), member 2
 19365
 0.14
chr22_27110582_27110733 0.24 CRYBA4
 crystallin, beta A4
 92729
 0.07
chr12_27535574_27535725 0.24 ARNTL2
 aryl hydrocarbon receptor nuclear translocator-like 2
 14380
 0.22
chr5_10583741_10584225 0.24 ANKRD33B
 ankyrin repeat domain 33B
 19403
 0.19
chr2_242285300_242285489 0.24 SEPT2
 septin 2
 4108
 0.17
chr14_89796285_89796436 0.24 RP11-356K23.1
20269
 0.18
chr7_114599509_114599660 0.24 MDFIC
 MyoD family inhibitor domain containing
 25660
 0.27
chr10_27949420_27949654 0.24 MKX
 mohawk homeobox
 82937
 0.09
chr8_127929746_127929897 0.24 ENSG00000212451
 .
 246054
 0.02
chr12_56917827_56917978 0.24 RBMS2
 RNA binding motif, single stranded interacting protein 2
 2119
 0.23
chr22_19786569_19786720 0.24 TBX1
 T-box 1
 42418
 0.11
chr17_14749052_14749203 0.24 ENSG00000238806
 .
 392073
 0.01
chr2_102672325_102672476 0.24 IL1R1
 interleukin 1 receptor, type I
 8604
 0.25
chr15_62709549_62709700 0.24 TLN2
 talin 2
 143940
 0.04
chr20_58831043_58831194 0.24 ENSG00000207802
 .
 52414
 0.17
chr6_146170436_146170587 0.24 RP11-545I5.3
34077
 0.16
chr6_154552039_154552289 0.24 IPCEF1
 interaction protein for cytohesin exchange factors 1
 15826
 0.29
chr12_7596689_7596840 0.24 CD163L1
 CD163 molecule-like 1
 15
 0.98
chr2_28303855_28304225 0.24 ENSG00000265321
 .
 84806
 0.09
chr22_27284432_27284583 0.24 ENSG00000200443
 .
 147343
 0.04
chr3_71589221_71589457 0.24 ENSG00000221264
 .
 1901
 0.34
chr12_891281_891511 0.23 ENSG00000221439
 .
 1097
 0.56
chr1_92017582_92017733 0.23 CDC7
 cell division cycle 7
 50962
 0.18
chr16_28192006_28192440 0.23 XPO6
 exportin 6
 220
 0.9
chr5_9541374_9541525 0.23 SEMA5A
 sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
 4738
 0.21
chr5_139074099_139074328 0.23 CXXC5
 CXXC finger protein 5
 14945
 0.19
chr4_86786101_86786252 0.23 ARHGAP24
 Rho GTPase activating protein 24
 37130
 0.18
chr13_111050622_111050773 0.23 ENSG00000238629
 .
 15855
 0.22
chr6_52460646_52460984 0.23 TRAM2
 translocation associated membrane protein 2
 19102
 0.21
chr9_113926250_113926401 0.23 ENSG00000212409
 .
 66632
 0.12
chr8_80226395_80226546 0.23 ENSG00000264969
 .
 216872
 0.02
chr4_95503122_95503273 0.23 PDLIM5
 PDZ and LIM domain 5
 58321
 0.16
chr3_112461104_112461256 0.23 ENSG00000242770
 .
 60145
 0.12
chr10_90006034_90006319 0.23 ENSG00000200891
 .
 251724
 0.02
chr8_72912474_72912625 0.23 TRPA1
 transient receptor potential cation channel, subfamily A, member 1
 65244
 0.13
chr9_112554949_112555100 0.23 AKAP2
 A kinase (PRKA) anchor protein 2
 12255
 0.16
chr16_66103982_66104133 0.23 ENSG00000201999
 .
 231655
 0.02
chr14_80777788_80777939 0.23 DIO2
 deiodinase, iodothyronine, type II
 4356
 0.35
chr17_66576104_66576255 0.23 FAM20A
 family with sequence similarity 20, member A
 21351
 0.19
chr3_129368691_129368842 0.23 TMCC1
 transmembrane and coiled-coil domain family 1
 6803
 0.21
chr1_24378269_24378420 0.23 RP11-293P20.2
11019
 0.14
chr1_11742391_11742542 0.23 MAD2L2
 MAD2 mitotic arrest deficient-like 2 (yeast)
 1195
 0.35
chr9_19031053_19031204 0.23 FAM154A
 family with sequence similarity 154, member A
 2058
 0.25
chr8_108160415_108160566 0.23 ENSG00000211995
 .
 106236
 0.08
chr18_32608835_32608986 0.23 MAPRE2
 microtubule-associated protein, RP/EB family, member 2
 12414
 0.29
chr5_158500324_158500475 0.23 EBF1
 early B-cell factor 1
 26302
 0.21
chr8_103836658_103836809 0.23 AZIN1
 antizyme inhibitor 1
 33597
 0.15
chr2_192574787_192574938 0.23 NABP1
 nucleic acid binding protein 1
 31146
 0.22
chr3_66038004_66038155 0.22 MAGI1
 membrane associated guanylate kinase, WW and PDZ domain containing 1
 13854
 0.22
chr6_134304861_134305059 0.22 TBPL1
 TBP-like 1
 30598
 0.19
chr5_130613_130764 0.22 PLEKHG4B
 pleckstrin homology domain containing, family G (with RhoGef domain) member 4B
 9685
 0.18
chr20_23757426_23757577 0.22 XXyac-YX60D10.1
21277
 0.17
chr8_8714840_8714991 0.22 MFHAS1
 malignant fibrous histiocytoma amplified sequence 1
 36240
 0.16
chr1_92163805_92163970 0.22 ENSG00000239794
 .
 131744
 0.05
chr8_119669977_119670128 0.22 SAMD12
 sterile alpha motif domain containing 12
 35818
 0.24
chr3_186945543_186945694 0.22 RP11-208N14.4
20201
 0.17
chr9_119036463_119036614 0.22 PAPPA-AS2
 PAPPA antisense RNA 2
 14510
 0.21
chr12_107771730_107771881 0.22 ENSG00000200897
 .
 3281
 0.33
chr2_85733181_85733461 0.22 ENSG00000266577
 .
 26428
 0.08
chr2_97019074_97019225 0.22 NCAPH
 non-SMC condensin I complex, subunit H
 11069
 0.15
chr13_114606657_114606808 0.22 GAS6
 growth arrest-specific 6
 39686
 0.19
chr21_30594818_30594969 0.22 BACH1
 BTB and CNC homology 1, basic leucine zipper transcription factor 1
 28425
 0.12
chr6_34314260_34314411 0.22 NUDT3
 nudix (nucleoside diphosphate linked moiety X)-type motif 3
 46116
 0.13
chr14_98691862_98692070 0.22 ENSG00000222066
 .
 106121
 0.08
chr3_177696159_177696310 0.22 ENSG00000199858
 .
 29333
 0.26
chr1_47764097_47764248 0.22 STIL
 SCL/TAL1 interrupting locus
 6817
 0.19
chr4_72154737_72154888 0.22 SLC4A4
 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
 49958
 0.19
chr8_19034553_19034704 0.22 PSD3
 pleckstrin and Sec7 domain containing 3
 92388
 0.09
chr17_66788465_66788616 0.22 ENSG00000263690
 .
 25840
 0.24
chr2_174788209_174788360 0.22 SP3
 Sp3 transcription factor
 40663
 0.22
chr6_39856229_39856380 0.22 RP11-61I13.3
403
 0.88
chr1_86022064_86022215 0.22 DDAH1
 dimethylarginine dimethylaminohydrolase 1
 21794
 0.18
chr3_99499403_99499554 0.22 CMSS1
 cms1 ribosomal small subunit homolog (yeast)
 37200
 0.18
chr6_56814587_56814738 0.22 ENSG00000200224
 .
 4134
 0.2
chr11_121975068_121975219 0.22 RP11-166D19.1
734
 0.61
chr10_15674894_15675045 0.22 ITGA8
 integrin, alpha 8
 87155
 0.1
chr7_16568149_16568300 0.21 LRRC72
 leucine rich repeat containing 72
 1703
 0.34
chr3_71023074_71023225 0.21 FOXP1
 forkhead box P1
 90928
 0.09
chr6_169568656_169568807 0.21 XXyac-YX65C7_A.2
44618
 0.19
chr6_16967524_16967675 0.21 STMND1
 stathmin domain containing 1
 134890
 0.05
chr3_120407358_120407509 0.21 HGD
 homogentisate 1,2-dioxygenase
 6015
 0.25
chr7_17134708_17134859 0.21 AC003075.4
186144
 0.03
chr16_84734828_84735251 0.21 USP10
 ubiquitin specific peptidase 10
 1393
 0.46
chr7_40832570_40832721 0.21 AC005160.3
17488
 0.3
chr3_71040530_71040681 0.21 FOXP1
 forkhead box P1
 73472
 0.12
chr4_119747895_119748046 0.21 SEC24D
 SEC24 family member D
 9323
 0.27
chr11_86651861_86652157 0.21 FZD4
 frizzled family receptor 4
 14424
 0.22

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of POU6F1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:1900116 sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.1 0.4 GO:0033152 immunoglobulin V(D)J recombination(GO:0033152)
0.1 0.3 GO:0060028 convergent extension involved in axis elongation(GO:0060028)
0.1 0.2 GO:0060523 prostate epithelial cord elongation(GO:0060523)
0.1 0.2 GO:0030210 heparin biosynthetic process(GO:0030210)
0.0 0.1 GO:0048388 endosomal lumen acidification(GO:0048388)
0.0 0.1 GO:0060413 atrial septum development(GO:0003283) atrial septum morphogenesis(GO:0060413)
0.0 0.1 GO:0071504 cellular response to heparin(GO:0071504)
0.0 0.2 GO:0060997 dendritic spine morphogenesis(GO:0060997) regulation of dendritic spine morphogenesis(GO:0061001) dendritic spine organization(GO:0097061)
0.0 0.1 GO:2000054 negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000054)
0.0 0.1 GO:0032509 endosome transport via multivesicular body sorting pathway(GO:0032509)
0.0 0.1 GO:0010667 striated muscle cell apoptotic process(GO:0010658) cardiac muscle cell apoptotic process(GO:0010659) regulation of striated muscle cell apoptotic process(GO:0010662) negative regulation of striated muscle cell apoptotic process(GO:0010664) regulation of cardiac muscle cell apoptotic process(GO:0010665) negative regulation of cardiac muscle cell apoptotic process(GO:0010667)
0.0 0.1 GO:0090292 nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0 0.1 GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.0 0.1 GO:0007028 cytoplasm organization(GO:0007028)
0.0 0.1 GO:0051124 synaptic growth at neuromuscular junction(GO:0051124)
0.0 0.1 GO:0048625 myoblast fate commitment(GO:0048625)
0.0 0.1 GO:0003323 type B pancreatic cell development(GO:0003323)
0.0 0.1 GO:0051532 NFAT protein import into nucleus(GO:0051531) regulation of NFAT protein import into nucleus(GO:0051532)
0.0 0.4 GO:0015701 bicarbonate transport(GO:0015701)
0.0 0.1 GO:0070672 response to interleukin-15(GO:0070672)
0.0 0.1 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
0.0 0.0 GO:0060594 mammary gland specification(GO:0060594)
0.0 0.1 GO:0010891 negative regulation of sequestering of triglyceride(GO:0010891)
0.0 0.1 GO:1901341 activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0 0.1 GO:0046827 positive regulation of protein export from nucleus(GO:0046827)
0.0 0.0 GO:0033173 calcineurin-NFAT signaling cascade(GO:0033173)
0.0 0.1 GO:0048003 antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003)
0.0 0.1 GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
0.0 0.1 GO:0060437 lung growth(GO:0060437)
0.0 0.0 GO:0033091 positive regulation of immature T cell proliferation(GO:0033091)
0.0 0.1 GO:0002870 lymphocyte anergy(GO:0002249) regulation of T cell anergy(GO:0002667) positive regulation of T cell anergy(GO:0002669) T cell anergy(GO:0002870) regulation of lymphocyte anergy(GO:0002911) positive regulation of lymphocyte anergy(GO:0002913)
0.0 0.1 GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.0 0.1 GO:0042268 regulation of cytolysis(GO:0042268)
0.0 0.1 GO:0006210 pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) thymine metabolic process(GO:0019859)
0.0 0.3 GO:0016578 histone deubiquitination(GO:0016578)
0.0 0.1 GO:0048149 behavioral response to ethanol(GO:0048149)
0.0 0.1 GO:0009756 carbohydrate mediated signaling(GO:0009756)
0.0 0.1 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.0 0.1 GO:0001779 natural killer cell differentiation(GO:0001779)
0.0 0.0 GO:0030644 cellular chloride ion homeostasis(GO:0030644) chloride ion homeostasis(GO:0055064)
0.0 0.1 GO:0051014 actin filament severing(GO:0051014)
0.0 0.1 GO:0008054 negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation(GO:0008054)
0.0 0.1 GO:0042483 negative regulation of odontogenesis(GO:0042483)
0.0 0.1 GO:0060670 branching involved in labyrinthine layer morphogenesis(GO:0060670)
0.0 0.1 GO:0046952 ketone body catabolic process(GO:0046952)
0.0 0.1 GO:0009649 entrainment of circadian clock(GO:0009649)
0.0 0.1 GO:0015871 choline transport(GO:0015871)
0.0 0.3 GO:0007032 endosome organization(GO:0007032)
0.0 0.0 GO:0051451 myoblast migration(GO:0051451)
0.0 0.1 GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518) negative regulation of signal transduction by p53 class mediator(GO:1901797)
0.0 0.1 GO:0034501 protein localization to kinetochore(GO:0034501)
0.0 0.0 GO:0001302 replicative cell aging(GO:0001302)
0.0 0.1 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.0 0.1 GO:0071354 cellular response to interleukin-6(GO:0071354)
0.0 0.0 GO:1901534 positive regulation of megakaryocyte differentiation(GO:0045654) positive regulation of hematopoietic progenitor cell differentiation(GO:1901534)
0.0 0.1 GO:0009221 pyrimidine deoxyribonucleotide biosynthetic process(GO:0009221)
0.0 0.1 GO:0031536 positive regulation of exit from mitosis(GO:0031536)
0.0 0.0 GO:0010761 fibroblast migration(GO:0010761)
0.0 0.0 GO:0006772 thiamine metabolic process(GO:0006772)
0.0 0.0 GO:0060463 lung lobe development(GO:0060462) lung lobe morphogenesis(GO:0060463)
0.0 0.0 GO:0006927 obsolete transformed cell apoptotic process(GO:0006927)
0.0 0.1 GO:0009414 response to water deprivation(GO:0009414)
0.0 0.0 GO:0035234 ectopic germ cell programmed cell death(GO:0035234)
0.0 0.0 GO:0035520 monoubiquitinated protein deubiquitination(GO:0035520)
0.0 0.0 GO:0045722 positive regulation of gluconeogenesis(GO:0045722)
0.0 0.0 GO:0046940 nucleoside monophosphate phosphorylation(GO:0046940)
0.0 0.4 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.0 0.0 GO:0009189 deoxyribonucleoside diphosphate biosynthetic process(GO:0009189)
0.0 0.0 GO:0009048 dosage compensation by inactivation of X chromosome(GO:0009048)
0.0 0.0 GO:0045343 MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343)
0.0 0.1 GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity(GO:0045197)
0.0 0.0 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0 0.0 GO:0045630 positive regulation of T-helper 2 cell differentiation(GO:0045630)
0.0 0.1 GO:0006590 thyroid hormone generation(GO:0006590)
0.0 0.2 GO:0006611 protein export from nucleus(GO:0006611)
0.0 0.0 GO:0034393 positive regulation of muscle cell apoptotic process(GO:0010661) positive regulation of smooth muscle cell apoptotic process(GO:0034393)
0.0 0.1 GO:0006477 protein sulfation(GO:0006477)
0.0 0.0 GO:0010936 negative regulation of macrophage cytokine production(GO:0010936)
0.0 0.0 GO:0051182 coenzyme transport(GO:0051182)
0.0 0.0 GO:0000470 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463) maturation of LSU-rRNA(GO:0000470)
0.0 0.0 GO:0048865 stem cell fate commitment(GO:0048865) stem cell fate determination(GO:0048867)
0.0 0.1 GO:0006572 tyrosine catabolic process(GO:0006572)
0.0 0.0 GO:0050651 dermatan sulfate proteoglycan biosynthetic process(GO:0050651)
0.0 0.1 GO:0000052 citrulline metabolic process(GO:0000052)
0.0 0.0 GO:0050703 interleukin-1 alpha secretion(GO:0050703)
0.0 0.0 GO:0045046 protein import into peroxisome membrane(GO:0045046)
0.0 0.1 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 0.0 GO:0032497 detection of lipopolysaccharide(GO:0032497)
0.0 0.0 GO:0016322 neuron remodeling(GO:0016322)
0.0 0.2 GO:0090659 adult walking behavior(GO:0007628) walking behavior(GO:0090659)
0.0 0.0 GO:1900619 acetylcholine metabolic process(GO:0008291) acetate ester metabolic process(GO:1900619)
0.0 0.0 GO:0032261 purine nucleotide salvage(GO:0032261)
0.0 0.2 GO:0006309 DNA catabolic process, endonucleolytic(GO:0000737) apoptotic DNA fragmentation(GO:0006309)
0.0 0.1 GO:0075713 establishment of viral latency(GO:0019043) establishment of integrated proviral latency(GO:0075713)
0.0 0.0 GO:0051834 evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.0 0.0 GO:0003032 detection of oxygen(GO:0003032)
0.0 0.1 GO:0042772 DNA damage response, signal transduction resulting in transcription(GO:0042772)
0.0 0.0 GO:0071364 cellular response to epidermal growth factor stimulus(GO:0071364)
0.0 0.0 GO:0051280 negative regulation of release of sequestered calcium ion into cytosol(GO:0051280) positive regulation of sequestering of calcium ion(GO:0051284) negative regulation of calcium ion transmembrane transport(GO:1903170)
0.0 0.1 GO:0043508 negative regulation of JUN kinase activity(GO:0043508)
0.0 0.0 GO:0006883 cellular sodium ion homeostasis(GO:0006883)
0.0 0.1 GO:0006448 regulation of translational elongation(GO:0006448)
0.0 0.0 GO:0021801 cerebral cortex radial glia guided migration(GO:0021801) telencephalon glial cell migration(GO:0022030)
0.0 0.0 GO:0002248 connective tissue replacement involved in inflammatory response wound healing(GO:0002248) connective tissue replacement(GO:0097709)
0.0 0.2 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0033268 node of Ranvier(GO:0033268)
0.0 0.1 GO:0030934 anchoring collagen complex(GO:0030934)
0.0 0.3 GO:0000125 PCAF complex(GO:0000125)
0.0 0.3 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.2 GO:0070695 FHF complex(GO:0070695)
0.0 0.1 GO:0005900 oncostatin-M receptor complex(GO:0005900)
0.0 0.1 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.1 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.1 GO:0032133 chromosome passenger complex(GO:0032133)
0.0 0.2 GO:0005606 laminin-1 complex(GO:0005606)
0.0 0.1 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 0.1 GO:0005954 calcium- and calmodulin-dependent protein kinase complex(GO:0005954)
0.0 0.1 GO:0033270 paranode region of axon(GO:0033270)
0.0 0.0 GO:0071664 catenin-TCF7L2 complex(GO:0071664)
0.0 0.1 GO:0033553 rDNA heterochromatin(GO:0033553)
0.0 0.1 GO:0071942 XPC complex(GO:0071942)
0.0 0.1 GO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958)
0.0 0.2 GO:0030315 T-tubule(GO:0030315)
0.0 0.1 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.2 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545) nuclear transcriptional repressor complex(GO:0090568)
0.0 0.1 GO:0001527 microfibril(GO:0001527)
0.0 0.2 GO:0032420 stereocilium(GO:0032420)
0.0 0.1 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 0.0 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0 0.1 GO:0032389 MutLalpha complex(GO:0032389)
0.0 0.0 GO:0070545 PeBoW complex(GO:0070545)
0.0 0.1 GO:0042575 DNA polymerase complex(GO:0042575)
0.0 0.0 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751) respiratory chain complex IV(GO:0045277)
0.0 0.1 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.0 0.2 GO:0005811 lipid particle(GO:0005811)
0.0 0.1 GO:0000796 condensin complex(GO:0000796)
0.0 0.1 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.1 0.2 GO:0016886 ligase activity, forming phosphoric ester bonds(GO:0016886)
0.0 0.2 GO:0047238 glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.0 0.2 GO:0030284 estrogen receptor activity(GO:0030284)
0.0 0.2 GO:0005110 frizzled-2 binding(GO:0005110)
0.0 0.1 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.0 0.3 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.0 0.1 GO:0000987 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.0 0.1 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.0 0.1 GO:0005030 neurotrophin receptor activity(GO:0005030)
0.0 0.1 GO:0033130 acetylcholine receptor binding(GO:0033130)
0.0 0.1 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.0 0.1 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.0 0.1 GO:0004924 oncostatin-M receptor activity(GO:0004924)
0.0 0.1 GO:0004800 thyroxine 5'-deiodinase activity(GO:0004800)
0.0 0.1 GO:0015204 urea transmembrane transporter activity(GO:0015204)
0.0 0.1 GO:0004967 glucagon receptor activity(GO:0004967)
0.0 0.1 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.0 0.2 GO:0001968 fibronectin binding(GO:0001968)
0.0 0.1 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.1 GO:0042805 actinin binding(GO:0042805)
0.0 0.1 GO:0070052 collagen V binding(GO:0070052)
0.0 0.1 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0 0.3 GO:0005248 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.0 0.0 GO:0048018 receptor agonist activity(GO:0048018)
0.0 0.2 GO:0030332 cyclin binding(GO:0030332)
0.0 0.2 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.1 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.0 0.1 GO:0050897 cobalt ion binding(GO:0050897)
0.0 0.1 GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.0 0.1 GO:0043237 laminin-1 binding(GO:0043237)
0.0 0.1 GO:0005042 netrin receptor activity(GO:0005042)
0.0 0.2 GO:0070411 I-SMAD binding(GO:0070411)
0.0 0.2 GO:0033613 activating transcription factor binding(GO:0033613)
0.0 0.1 GO:0030274 LIM domain binding(GO:0030274)
0.0 0.0 GO:0050510 N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510)
0.0 0.1 GO:0005522 profilin binding(GO:0005522)
0.0 0.1 GO:0005521 lamin binding(GO:0005521)
0.0 0.0 GO:0003987 acetate-CoA ligase activity(GO:0003987)
0.0 0.1 GO:0019237 centromeric DNA binding(GO:0019237)
0.0 0.0 GO:0034186 apolipoprotein A-I binding(GO:0034186)
0.0 0.1 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.0 0.1 GO:0005047 signal recognition particle binding(GO:0005047)
0.0 0.2 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656)
0.0 0.0 GO:0004784 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.0 0.2 GO:0005024 transforming growth factor beta-activated receptor activity(GO:0005024)
0.0 0.0 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0 0.0 GO:0010485 H4 histone acetyltransferase activity(GO:0010485)
0.0 0.0 GO:0004127 cytidylate kinase activity(GO:0004127)
0.0 0.0 GO:0051880 G-quadruplex DNA binding(GO:0051880)
0.0 0.0 GO:0045545 syndecan binding(GO:0045545)
0.0 0.2 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 0.0 GO:0015106 bicarbonate transmembrane transporter activity(GO:0015106)
0.0 0.1 GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
0.0 0.1 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.0 0.0 GO:0042978 ornithine decarboxylase activator activity(GO:0042978)
0.0 0.0 GO:0005350 pyrimidine nucleobase transmembrane transporter activity(GO:0005350)
0.0 0.1 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
0.0 0.0 GO:0004117 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 PID AVB3 OPN PATHWAY Osteopontin-mediated events
0.0 0.1 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 0.1 SA TRKA RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.0 0.1 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 0.0 PID SHP2 PATHWAY SHP2 signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.0 0.3 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 0.1 REACTOME INTEGRATION OF PROVIRUS Genes involved in Integration of provirus
0.0 0.0 REACTOME DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR Genes involved in Downstream Signaling Events Of B Cell Receptor (BCR)
0.0 0.0 REACTOME REGULATION OF APOPTOSIS Genes involved in Regulation of Apoptosis
0.0 0.0 REACTOME CTLA4 INHIBITORY SIGNALING Genes involved in CTLA4 inhibitory signaling
0.0 0.0 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 0.2 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 0.1 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 0.1 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 0.2 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 0.1 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 0.0 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression