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ENCODE: H3K4me1 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for POU6F1

Z-value: 1.04

Motif logo

Transcription factors associated with POU6F1

Gene Symbol	Gene ID	Gene Info
POU6F1 Ensembl NCBI GeneCards UniProt	ENSG00000184271.11	POU6F1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
POU6F1	chr12_51612102_51612253	700	0.581175	-0.76	1.7e-02	Click!
POU6F1	chr12_51580556_51580707	10187	0.123099	-0.69	3.9e-02	Click!
POU6F1	chr12_51610080_51610231	1322	0.335665	0.69	4.0e-02	Click!
POU6F1	chr12_51612401_51612910	1178	0.372640	-0.63	6.9e-02	Click!
POU6F1	chr12_51610871_51611203	440	0.756378	-0.61	8.2e-02	Click!

Activity of the POU6F1 motif across conditions

Conditions sorted by the z-value of the POU6F1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr4_170638169_170638320	0.56	CLCN3	chloride channel, voltage-sensitive 3	21462	0.2
chr17_54218727_54219172	0.46	ANKFN1	ankyrin-repeat and fibronectin type III domain containing 1	11887	0.29
chr12_28716405_28716556	0.43	CCDC91	coiled-coil domain containing 91	14483	0.27
chr1_52435800_52436083	0.43	ENSG00000200839	.	3141	0.18
chr3_39031899_39032050	0.42	ENSG00000206708	.	35504	0.14
chr5_139049687_139050600	0.42	CXXC5	CXXC finger protein 5	4878	0.24
chr5_35626957_35627108	0.42	ENSG00000238441	.	6094	0.25
chr13_66381692_66381843	0.42	ENSG00000221685	.	56538	0.17
chr5_41796126_41796277	0.41	OXCT1	3-oxoacid CoA transferase 1	1516	0.51
chr6_125541820_125541971	0.40	TPD52L1	tumor protein D52-like 1	904	0.71
chr8_121680676_121680965	0.39	RP11-713M15.1		92673	0.09
chr5_15691172_15691323	0.36	FBXL7	F-box and leucine-rich repeat protein 7	75156	0.11
chr8_122843360_122843511	0.36	HAS2-AS1	HAS2 antisense RNA 1	189759	0.03
chr2_200205268_200205419	0.34	RP11-486F17.1		15310	0.28
chr8_129527596_129527747	0.34	ENSG00000201782	.	294921	0.01
chr2_68025793_68025944	0.33	C1D	C1D nuclear receptor corepressor	264246	0.02
chr18_46270227_46270648	0.33	RP11-426J5.2		55647	0.13
chr3_148722415_148722820	0.33	GYG1	glycogenin 1	12459	0.19
chr2_33466958_33467109	0.32	LTBP1	latent transforming growth factor beta binding protein 1	1696	0.46
chr6_148845405_148845556	0.32	ENSG00000223322	.	104	0.98
chr11_119438895_119439046	0.32	RP11-196E1.3		40165	0.15
chr6_113253230_113253381	0.32	ENSG00000201386	.	39390	0.23
chr11_129920633_129920906	0.32	AP003041.2	Uncharacterized protein	16067	0.19
chr3_52683246_52683397	0.32	PBRM1	polybromo 1	29262	0.08
chr7_81227564_81227715	0.32	HGF	hepatocyte growth factor (hepapoietin A; scatter factor)	164673	0.04
chr19_47418746_47418897	0.32	ARHGAP35	Rho GTPase activating protein 35	3112	0.23
chr13_75465674_75465825	0.31	ENSG00000206812	.	217975	0.02
chr8_59979328_59979517	0.31	RP11-25K19.1		52177	0.13
chr8_119778166_119778317	0.30	SAMD12	sterile alpha motif domain containing 12	144007	0.05
chr5_146749657_146749808	0.30	DPYSL3	dihydropyrimidinase-like 3	31433	0.19
chr3_64448583_64448734	0.30	PRICKLE2	prickle homolog 2 (Drosophila)	17506	0.23
chr10_733389_733540	0.30	DIP2C	DIP2 disco-interacting protein 2 homolog C (Drosophila)	2142	0.29
chr9_113941044_113941228	0.30	ENSG00000212409	.	81443	0.1
chr13_74701587_74701980	0.30	KLF12	Kruppel-like factor 12	6611	0.34
chr11_70170303_70170454	0.30	CTA-797E19.2		2937	0.16
chr5_52151940_52152091	0.30	CTD-2288O8.1		68155	0.1
chr4_113437546_113438608	0.30	NEUROG2	neurogenin 2	749	0.58
chr14_65552013_65552503	0.29	RP11-840I19.3		3506	0.19
chr13_33249941_33250092	0.29	PDS5B	PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)	82291	0.09
chr15_49530289_49530440	0.29	ENSG00000243338	.	38973	0.14
chr15_70920408_70920559	0.29	UACA	uveal autoantigen with coiled-coil domains and ankyrin repeats	74137	0.12
chr18_21470429_21470580	0.29	ENSG00000221389	.	3666	0.25
chr3_125401874_125402052	0.29	ENSG00000266857	.	7137	0.22
chr9_3342035_3342186	0.29	RFX3	regulatory factor X, 3 (influences HLA class II expression)	4654	0.35
chr8_19489778_19489959	0.29	CSGALNACT1	chondroitin sulfate N-acetylgalactosaminyltransferase 1	29862	0.25
chr10_62109936_62110087	0.29	ANK3	ankyrin 3, node of Ranvier (ankyrin G)	39477	0.23
chr14_69220818_69221003	0.29	ENSG00000207089	.	18165	0.2
chr3_149808903_149809054	0.29	RP11-167H9.4		5252	0.22
chr2_185461548_185461699	0.29	ZNF804A	zinc finger protein 804A	1470	0.6
chr3_129311849_129312381	0.29	ENSG00000239437	.	1923	0.28
chr13_22272696_22272847	0.28	FGF9	fibroblast growth factor 9	27249	0.22
chr14_61557835_61557986	0.28	SLC38A6	solute carrier family 38, member 6	48042	0.15
chr12_109042760_109042911	0.28	CORO1C	coronin, actin binding protein, 1C	3286	0.17
chr4_114609792_114609943	0.28	CAMK2D	calcium/calmodulin-dependent protein kinase II delta	72357	0.13
chr8_25779248_25779399	0.28	EBF2	early B-cell factor 2	33891	0.24
chr1_183106798_183106949	0.28	RP11-181K3.4		3544	0.27
chr15_77747199_77747484	0.28	HMG20A	high mobility group 20A	3218	0.31
chr3_159740833_159741097	0.28	LINC01100	long intergenic non-protein coding RNA 1100	7154	0.2
chr12_68841133_68841474	0.28	MDM1	Mdm1 nuclear protein homolog (mouse)	115142	0.06
chr3_46023429_46023580	0.28	FYCO1	FYVE and coiled-coil domain containing 1	2983	0.25
chr7_71564289_71564440	0.28	CALN1	calneuron 1	179424	0.03
chr1_109920976_109921127	0.28	SORT1	sortilin 1	14928	0.15
chr7_77130046_77130330	0.28	PTPN12	protein tyrosine phosphatase, non-receptor type 12	36404	0.19
chr9_140215104_140215809	0.28	NRARP	NOTCH-regulated ankyrin repeat protein	18753	0.09
chr13_115076948_115077099	0.27	CHAMP1	chromosome alignment maintaining phosphoprotein 1	2965	0.23
chr10_22725352_22725818	0.27	RP11-301N24.3		75484	0.09
chr7_98475291_98476046	0.27	TRRAP	transformation/transcription domain-associated protein	112	0.95
chr3_43769942_43770093	0.27	ABHD5	abhydrolase domain containing 5	16818	0.24
chr6_106612627_106612780	0.27	RP1-134E15.3		64688	0.11
chr5_100764513_100764664	0.27	ENSG00000264318	.	152946	0.05
chr15_91007004_91007155	0.27	RP11-154B12.3		65966	0.08
chr2_225410033_225410184	0.27	CUL3	cullin 3	17908	0.29
chr7_132617410_132617561	0.27	AC009518.8		102032	0.07
chr8_126588731_126588882	0.26	ENSG00000266452	.	131999	0.05
chr13_34110896_34111047	0.26	STARD13	StAR-related lipid transfer (START) domain containing 13	186204	0.03
chr15_96885439_96885590	0.26	ENSG00000222651	.	9024	0.16
chr1_21318917_21319257	0.26	ENSG00000221808	.	4162	0.26
chr1_98377242_98377756	0.26	DPYD	dihydropyrimidine dehydrogenase	9054	0.31
chr1_203516920_203517071	0.26	OPTC	opticin	51897	0.13
chr1_54557402_54557553	0.26	AL161915.1	Uncharacterized protein	12491	0.14
chr5_98057263_98057414	0.26	RGMB	repulsive guidance molecule family member b	47661	0.15
chr13_111053690_111053841	0.26	ENSG00000238629	.	12787	0.23
chr8_18707372_18707523	0.26	PSD3	pleckstrin and Sec7 domain containing 3	4437	0.29
chr1_82386697_82386848	0.26	LPHN2	latrophilin 2	21881	0.29
chr12_1740008_1740328	0.26	WNT5B	wingless-type MMTV integration site family, member 5B	190	0.95
chr2_190538393_190538544	0.26	ANKAR	ankyrin and armadillo repeat containing	2243	0.28
chr18_66106660_66106811	0.26	TMX3	thioredoxin-related transmembrane protein 3	275559	0.02
chr12_52080077_52080228	0.26	SCN8A	sodium channel, voltage gated, type VIII, alpha subunit	55	0.98
chr2_60711834_60711985	0.26	AC009970.1		10912	0.25
chr21_38512491_38512642	0.26	TTC3	tetratricopeptide repeat domain 3	4294	0.2
chr2_40573390_40573541	0.26	SLC8A1	solute carrier family 8 (sodium/calcium exchanger), member 1	83955	0.1
chr5_34523547_34523698	0.26	RAI14	retinoic acid induced 14	132720	0.05
chr10_112689960_112690181	0.25	SHOC2	soc-2 suppressor of clear homolog (C. elegans)	10765	0.14
chr11_88136410_88136561	0.25	CTSC	cathepsin C	65530	0.13
chr10_72965207_72965358	0.25	UNC5B	unc-5 homolog B (C. elegans)	7045	0.19
chr22_43324968_43325242	0.25	PACSIN2	protein kinase C and casein kinase substrate in neurons 2	16774	0.21
chr4_20489405_20489556	0.25	ENSG00000207732	.	40418	0.18
chr11_45103871_45104025	0.25	PRDM11	PR domain containing 11	11616	0.28
chr3_29228707_29228858	0.25	RBMS3	RNA binding motif, single stranded interacting protein 3	93691	0.09
chr2_62899326_62899477	0.25	EHBP1	EH domain binding protein 1	1585	0.42
chr10_80870080_80870231	0.25	ZMIZ1	zinc finger, MIZ-type containing 1	41363	0.18
chr9_21081966_21082494	0.25	IFNB1	interferon, beta 1, fibroblast	4287	0.21
chr2_133435941_133436092	0.25	LYPD1	LY6/PLAUR domain containing 1	6864	0.25
chr8_62658133_62658284	0.25	ENSG00000264408	.	30861	0.2
chr8_116430587_116430872	0.25	TRPS1	trichorhinophalangeal syndrome I	73719	0.12
chr1_101073343_101073642	0.25	GPR88	G protein-coupled receptor 88	69799	0.11
chr8_118889653_118889804	0.25	EXT1	exostosin glycosyltransferase 1	232925	0.02
chr9_16218365_16218516	0.25	C9orf92	chromosome 9 open reading frame 92	2543	0.44
chr3_16483097_16483616	0.25	RFTN1	raftlin, lipid raft linker 1	41016	0.17
chr14_90788424_90788710	0.25	NRDE2	NRDE-2, necessary for RNA interference, domain containing	9712	0.21
chr7_150940874_150941828	0.25	RP4-548D19.3		3866	0.11
chr7_47579797_47580043	0.25	TNS3	tensin 3	721	0.8
chr20_43120077_43120228	0.24	SERINC3	serine incorporator 3	13380	0.12
chr11_35267852_35268003	0.24	SLC1A2	solute carrier family 1 (glial high affinity glutamate transporter), member 2	19365	0.14
chr22_27110582_27110733	0.24	CRYBA4	crystallin, beta A4	92729	0.07
chr12_27535574_27535725	0.24	ARNTL2	aryl hydrocarbon receptor nuclear translocator-like 2	14380	0.22
chr5_10583741_10584225	0.24	ANKRD33B	ankyrin repeat domain 33B	19403	0.19
chr2_242285300_242285489	0.24	SEPT2	septin 2	4108	0.17
chr14_89796285_89796436	0.24	RP11-356K23.1		20269	0.18
chr7_114599509_114599660	0.24	MDFIC	MyoD family inhibitor domain containing	25660	0.27
chr10_27949420_27949654	0.24	MKX	mohawk homeobox	82937	0.09
chr8_127929746_127929897	0.24	ENSG00000212451	.	246054	0.02
chr12_56917827_56917978	0.24	RBMS2	RNA binding motif, single stranded interacting protein 2	2119	0.23
chr22_19786569_19786720	0.24	TBX1	T-box 1	42418	0.11
chr17_14749052_14749203	0.24	ENSG00000238806	.	392073	0.01
chr2_102672325_102672476	0.24	IL1R1	interleukin 1 receptor, type I	8604	0.25
chr15_62709549_62709700	0.24	TLN2	talin 2	143940	0.04
chr20_58831043_58831194	0.24	ENSG00000207802	.	52414	0.17
chr6_146170436_146170587	0.24	RP11-545I5.3		34077	0.16
chr6_154552039_154552289	0.24	IPCEF1	interaction protein for cytohesin exchange factors 1	15826	0.29
chr12_7596689_7596840	0.24	CD163L1	CD163 molecule-like 1	15	0.98
chr2_28303855_28304225	0.24	ENSG00000265321	.	84806	0.09
chr22_27284432_27284583	0.24	ENSG00000200443	.	147343	0.04
chr3_71589221_71589457	0.24	ENSG00000221264	.	1901	0.34
chr12_891281_891511	0.23	ENSG00000221439	.	1097	0.56
chr1_92017582_92017733	0.23	CDC7	cell division cycle 7	50962	0.18
chr16_28192006_28192440	0.23	XPO6	exportin 6	220	0.9
chr5_9541374_9541525	0.23	SEMA5A	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A	4738	0.21
chr5_139074099_139074328	0.23	CXXC5	CXXC finger protein 5	14945	0.19
chr4_86786101_86786252	0.23	ARHGAP24	Rho GTPase activating protein 24	37130	0.18
chr13_111050622_111050773	0.23	ENSG00000238629	.	15855	0.22
chr6_52460646_52460984	0.23	TRAM2	translocation associated membrane protein 2	19102	0.21
chr9_113926250_113926401	0.23	ENSG00000212409	.	66632	0.12
chr8_80226395_80226546	0.23	ENSG00000264969	.	216872	0.02
chr4_95503122_95503273	0.23	PDLIM5	PDZ and LIM domain 5	58321	0.16
chr3_112461104_112461256	0.23	ENSG00000242770	.	60145	0.12
chr10_90006034_90006319	0.23	ENSG00000200891	.	251724	0.02
chr8_72912474_72912625	0.23	TRPA1	transient receptor potential cation channel, subfamily A, member 1	65244	0.13
chr9_112554949_112555100	0.23	AKAP2	A kinase (PRKA) anchor protein 2	12255	0.16
chr16_66103982_66104133	0.23	ENSG00000201999	.	231655	0.02
chr14_80777788_80777939	0.23	DIO2	deiodinase, iodothyronine, type II	4356	0.35
chr17_66576104_66576255	0.23	FAM20A	family with sequence similarity 20, member A	21351	0.19
chr3_129368691_129368842	0.23	TMCC1	transmembrane and coiled-coil domain family 1	6803	0.21
chr1_24378269_24378420	0.23	RP11-293P20.2		11019	0.14
chr1_11742391_11742542	0.23	MAD2L2	MAD2 mitotic arrest deficient-like 2 (yeast)	1195	0.35
chr9_19031053_19031204	0.23	FAM154A	family with sequence similarity 154, member A	2058	0.25
chr8_108160415_108160566	0.23	ENSG00000211995	.	106236	0.08
chr18_32608835_32608986	0.23	MAPRE2	microtubule-associated protein, RP/EB family, member 2	12414	0.29
chr5_158500324_158500475	0.23	EBF1	early B-cell factor 1	26302	0.21
chr8_103836658_103836809	0.23	AZIN1	antizyme inhibitor 1	33597	0.15
chr2_192574787_192574938	0.23	NABP1	nucleic acid binding protein 1	31146	0.22
chr3_66038004_66038155	0.22	MAGI1	membrane associated guanylate kinase, WW and PDZ domain containing 1	13854	0.22
chr6_134304861_134305059	0.22	TBPL1	TBP-like 1	30598	0.19
chr5_130613_130764	0.22	PLEKHG4B	pleckstrin homology domain containing, family G (with RhoGef domain) member 4B	9685	0.18
chr20_23757426_23757577	0.22	XXyac-YX60D10.1		21277	0.17
chr8_8714840_8714991	0.22	MFHAS1	malignant fibrous histiocytoma amplified sequence 1	36240	0.16
chr1_92163805_92163970	0.22	ENSG00000239794	.	131744	0.05
chr8_119669977_119670128	0.22	SAMD12	sterile alpha motif domain containing 12	35818	0.24
chr3_186945543_186945694	0.22	RP11-208N14.4		20201	0.17
chr9_119036463_119036614	0.22	PAPPA-AS2	PAPPA antisense RNA 2	14510	0.21
chr12_107771730_107771881	0.22	ENSG00000200897	.	3281	0.33
chr2_85733181_85733461	0.22	ENSG00000266577	.	26428	0.08
chr2_97019074_97019225	0.22	NCAPH	non-SMC condensin I complex, subunit H	11069	0.15
chr13_114606657_114606808	0.22	GAS6	growth arrest-specific 6	39686	0.19
chr21_30594818_30594969	0.22	BACH1	BTB and CNC homology 1, basic leucine zipper transcription factor 1	28425	0.12
chr6_34314260_34314411	0.22	NUDT3	nudix (nucleoside diphosphate linked moiety X)-type motif 3	46116	0.13
chr14_98691862_98692070	0.22	ENSG00000222066	.	106121	0.08
chr3_177696159_177696310	0.22	ENSG00000199858	.	29333	0.26
chr1_47764097_47764248	0.22	STIL	SCL/TAL1 interrupting locus	6817	0.19
chr4_72154737_72154888	0.22	SLC4A4	solute carrier family 4 (sodium bicarbonate cotransporter), member 4	49958	0.19
chr8_19034553_19034704	0.22	PSD3	pleckstrin and Sec7 domain containing 3	92388	0.09
chr17_66788465_66788616	0.22	ENSG00000263690	.	25840	0.24
chr2_174788209_174788360	0.22	SP3	Sp3 transcription factor	40663	0.22
chr6_39856229_39856380	0.22	RP11-61I13.3		403	0.88
chr1_86022064_86022215	0.22	DDAH1	dimethylarginine dimethylaminohydrolase 1	21794	0.18
chr3_99499403_99499554	0.22	CMSS1	cms1 ribosomal small subunit homolog (yeast)	37200	0.18
chr6_56814587_56814738	0.22	ENSG00000200224	.	4134	0.2
chr11_121975068_121975219	0.22	RP11-166D19.1		734	0.61
chr10_15674894_15675045	0.22	ITGA8	integrin, alpha 8	87155	0.1
chr7_16568149_16568300	0.21	LRRC72	leucine rich repeat containing 72	1703	0.34
chr3_71023074_71023225	0.21	FOXP1	forkhead box P1	90928	0.09
chr6_169568656_169568807	0.21	XXyac-YX65C7_A.2		44618	0.19
chr6_16967524_16967675	0.21	STMND1	stathmin domain containing 1	134890	0.05
chr3_120407358_120407509	0.21	HGD	homogentisate 1,2-dioxygenase	6015	0.25
chr7_17134708_17134859	0.21	AC003075.4		186144	0.03
chr16_84734828_84735251	0.21	USP10	ubiquitin specific peptidase 10	1393	0.46
chr7_40832570_40832721	0.21	AC005160.3		17488	0.3
chr3_71040530_71040681	0.21	FOXP1	forkhead box P1	73472	0.12
chr4_119747895_119748046	0.21	SEC24D	SEC24 family member D	9323	0.27
chr11_86651861_86652157	0.21	FZD4	frizzled family receptor 4	14424	0.22

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of POU6F1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.5	GO:1900116	sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.1	0.4	GO:0033152	immunoglobulin V(D)J recombination(GO:0033152)
0.1	0.3	GO:0060028	convergent extension involved in axis elongation(GO:0060028)
0.1	0.2	GO:0060523	prostate epithelial cord elongation(GO:0060523)
0.1	0.2	GO:0030210	heparin biosynthetic process(GO:0030210)
0.0	0.1	GO:0048388	endosomal lumen acidification(GO:0048388)
0.0	0.1	GO:0060413	atrial septum development(GO:0003283) atrial septum morphogenesis(GO:0060413)
0.0	0.1	GO:0071504	cellular response to heparin(GO:0071504)
0.0	0.2	GO:0060997	dendritic spine morphogenesis(GO:0060997) regulation of dendritic spine morphogenesis(GO:0061001) dendritic spine organization(GO:0097061)
0.0	0.1	GO:2000054	negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000054)
0.0	0.1	GO:0032509	endosome transport via multivesicular body sorting pathway(GO:0032509)
0.0	0.1	GO:0010667	striated muscle cell apoptotic process(GO:0010658) cardiac muscle cell apoptotic process(GO:0010659) regulation of striated muscle cell apoptotic process(GO:0010662) negative regulation of striated muscle cell apoptotic process(GO:0010664) regulation of cardiac muscle cell apoptotic process(GO:0010665) negative regulation of cardiac muscle cell apoptotic process(GO:0010667)
0.0	0.1	GO:0090292	nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0	0.1	GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.0	0.1	GO:0007028	cytoplasm organization(GO:0007028)
0.0	0.1	GO:0051124	synaptic growth at neuromuscular junction(GO:0051124)
0.0	0.1	GO:0048625	myoblast fate commitment(GO:0048625)
0.0	0.1	GO:0003323	type B pancreatic cell development(GO:0003323)
0.0	0.1	GO:0051532	NFAT protein import into nucleus(GO:0051531) regulation of NFAT protein import into nucleus(GO:0051532)
0.0	0.4	GO:0015701	bicarbonate transport(GO:0015701)
0.0	0.1	GO:0070672	response to interleukin-15(GO:0070672)
0.0	0.1	GO:0035426	extracellular matrix-cell signaling(GO:0035426)
0.0	0.0	GO:0060594	mammary gland specification(GO:0060594)
0.0	0.1	GO:0010891	negative regulation of sequestering of triglyceride(GO:0010891)
0.0	0.1	GO:1901341	activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0	0.1	GO:0046827	positive regulation of protein export from nucleus(GO:0046827)
0.0	0.0	GO:0033173	calcineurin-NFAT signaling cascade(GO:0033173)
0.0	0.1	GO:0048003	antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003)
0.0	0.1	GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
0.0	0.1	GO:0060437	lung growth(GO:0060437)
0.0	0.0	GO:0033091	positive regulation of immature T cell proliferation(GO:0033091)
0.0	0.1	GO:0002870	lymphocyte anergy(GO:0002249) regulation of T cell anergy(GO:0002667) positive regulation of T cell anergy(GO:0002669) T cell anergy(GO:0002870) regulation of lymphocyte anergy(GO:0002911) positive regulation of lymphocyte anergy(GO:0002913)
0.0	0.1	GO:0060666	dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.0	0.1	GO:0042268	regulation of cytolysis(GO:0042268)
0.0	0.1	GO:0006210	pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) thymine metabolic process(GO:0019859)
0.0	0.3	GO:0016578	histone deubiquitination(GO:0016578)
0.0	0.1	GO:0048149	behavioral response to ethanol(GO:0048149)
0.0	0.1	GO:0009756	carbohydrate mediated signaling(GO:0009756)
0.0	0.1	GO:0006610	ribosomal protein import into nucleus(GO:0006610)
0.0	0.1	GO:0001779	natural killer cell differentiation(GO:0001779)
0.0	0.0	GO:0030644	cellular chloride ion homeostasis(GO:0030644) chloride ion homeostasis(GO:0055064)
0.0	0.1	GO:0051014	actin filament severing(GO:0051014)
0.0	0.1	GO:0008054	negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation(GO:0008054)
0.0	0.1	GO:0042483	negative regulation of odontogenesis(GO:0042483)
0.0	0.1	GO:0060670	branching involved in labyrinthine layer morphogenesis(GO:0060670)
0.0	0.1	GO:0046952	ketone body catabolic process(GO:0046952)
0.0	0.1	GO:0009649	entrainment of circadian clock(GO:0009649)
0.0	0.1	GO:0015871	choline transport(GO:0015871)
0.0	0.3	GO:0007032	endosome organization(GO:0007032)
0.0	0.0	GO:0051451	myoblast migration(GO:0051451)
0.0	0.1	GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518) negative regulation of signal transduction by p53 class mediator(GO:1901797)
0.0	0.1	GO:0034501	protein localization to kinetochore(GO:0034501)
0.0	0.0	GO:0001302	replicative cell aging(GO:0001302)
0.0	0.1	GO:0030854	positive regulation of granulocyte differentiation(GO:0030854)
0.0	0.1	GO:0071354	cellular response to interleukin-6(GO:0071354)
0.0	0.0	GO:1901534	positive regulation of megakaryocyte differentiation(GO:0045654) positive regulation of hematopoietic progenitor cell differentiation(GO:1901534)
0.0	0.1	GO:0009221	pyrimidine deoxyribonucleotide biosynthetic process(GO:0009221)
0.0	0.1	GO:0031536	positive regulation of exit from mitosis(GO:0031536)
0.0	0.0	GO:0010761	fibroblast migration(GO:0010761)
0.0	0.0	GO:0006772	thiamine metabolic process(GO:0006772)
0.0	0.0	GO:0060463	lung lobe development(GO:0060462) lung lobe morphogenesis(GO:0060463)
0.0	0.0	GO:0006927	obsolete transformed cell apoptotic process(GO:0006927)
0.0	0.1	GO:0009414	response to water deprivation(GO:0009414)
0.0	0.0	GO:0035234	ectopic germ cell programmed cell death(GO:0035234)
0.0	0.0	GO:0035520	monoubiquitinated protein deubiquitination(GO:0035520)
0.0	0.0	GO:0045722	positive regulation of gluconeogenesis(GO:0045722)
0.0	0.0	GO:0046940	nucleoside monophosphate phosphorylation(GO:0046940)
0.0	0.4	GO:0010811	positive regulation of cell-substrate adhesion(GO:0010811)
0.0	0.0	GO:0009189	deoxyribonucleoside diphosphate biosynthetic process(GO:0009189)
0.0	0.0	GO:0009048	dosage compensation by inactivation of X chromosome(GO:0009048)
0.0	0.0	GO:0045343	MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343)
0.0	0.1	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity(GO:0045197)
0.0	0.0	GO:0070779	D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0	0.0	GO:0045630	positive regulation of T-helper 2 cell differentiation(GO:0045630)
0.0	0.1	GO:0006590	thyroid hormone generation(GO:0006590)
0.0	0.2	GO:0006611	protein export from nucleus(GO:0006611)
0.0	0.0	GO:0034393	positive regulation of muscle cell apoptotic process(GO:0010661) positive regulation of smooth muscle cell apoptotic process(GO:0034393)
0.0	0.1	GO:0006477	protein sulfation(GO:0006477)
0.0	0.0	GO:0010936	negative regulation of macrophage cytokine production(GO:0010936)
0.0	0.0	GO:0051182	coenzyme transport(GO:0051182)
0.0	0.0	GO:0000470	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463) maturation of LSU-rRNA(GO:0000470)
0.0	0.0	GO:0048865	stem cell fate commitment(GO:0048865) stem cell fate determination(GO:0048867)
0.0	0.1	GO:0006572	tyrosine catabolic process(GO:0006572)
0.0	0.0	GO:0050651	dermatan sulfate proteoglycan biosynthetic process(GO:0050651)
0.0	0.1	GO:0000052	citrulline metabolic process(GO:0000052)
0.0	0.0	GO:0050703	interleukin-1 alpha secretion(GO:0050703)
0.0	0.0	GO:0045046	protein import into peroxisome membrane(GO:0045046)
0.0	0.1	GO:0031581	hemidesmosome assembly(GO:0031581)
0.0	0.0	GO:0032497	detection of lipopolysaccharide(GO:0032497)
0.0	0.0	GO:0016322	neuron remodeling(GO:0016322)
0.0	0.2	GO:0090659	adult walking behavior(GO:0007628) walking behavior(GO:0090659)
0.0	0.0	GO:1900619	acetylcholine metabolic process(GO:0008291) acetate ester metabolic process(GO:1900619)
0.0	0.0	GO:0032261	purine nucleotide salvage(GO:0032261)
0.0	0.2	GO:0006309	DNA catabolic process, endonucleolytic(GO:0000737) apoptotic DNA fragmentation(GO:0006309)
0.0	0.1	GO:0075713	establishment of viral latency(GO:0019043) establishment of integrated proviral latency(GO:0075713)
0.0	0.0	GO:0051834	evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.0	0.0	GO:0003032	detection of oxygen(GO:0003032)
0.0	0.1	GO:0042772	DNA damage response, signal transduction resulting in transcription(GO:0042772)
0.0	0.0	GO:0071364	cellular response to epidermal growth factor stimulus(GO:0071364)
0.0	0.0	GO:0051280	negative regulation of release of sequestered calcium ion into cytosol(GO:0051280) positive regulation of sequestering of calcium ion(GO:0051284) negative regulation of calcium ion transmembrane transport(GO:1903170)
0.0	0.1	GO:0043508	negative regulation of JUN kinase activity(GO:0043508)
0.0	0.0	GO:0006883	cellular sodium ion homeostasis(GO:0006883)
0.0	0.1	GO:0006448	regulation of translational elongation(GO:0006448)
0.0	0.0	GO:0021801	cerebral cortex radial glia guided migration(GO:0021801) telencephalon glial cell migration(GO:0022030)
0.0	0.0	GO:0002248	connective tissue replacement involved in inflammatory response wound healing(GO:0002248) connective tissue replacement(GO:0097709)
0.0	0.2	GO:0032012	regulation of ARF protein signal transduction(GO:0032012)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0033268	node of Ranvier(GO:0033268)
0.0	0.1	GO:0030934	anchoring collagen complex(GO:0030934)
0.0	0.3	GO:0000125	PCAF complex(GO:0000125)
0.0	0.3	GO:0005614	interstitial matrix(GO:0005614)
0.0	0.2	GO:0070695	FHF complex(GO:0070695)
0.0	0.1	GO:0005900	oncostatin-M receptor complex(GO:0005900)
0.0	0.1	GO:0016327	apicolateral plasma membrane(GO:0016327)
0.0	0.1	GO:0030056	hemidesmosome(GO:0030056)
0.0	0.1	GO:0032133	chromosome passenger complex(GO:0032133)
0.0	0.2	GO:0005606	laminin-1 complex(GO:0005606)
0.0	0.1	GO:0034993	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0	0.1	GO:0005954	calcium- and calmodulin-dependent protein kinase complex(GO:0005954)
0.0	0.1	GO:0033270	paranode region of axon(GO:0033270)
0.0	0.0	GO:0071664	catenin-TCF7L2 complex(GO:0071664)
0.0	0.1	GO:0033553	rDNA heterochromatin(GO:0033553)
0.0	0.1	GO:0071942	XPC complex(GO:0071942)
0.0	0.1	GO:0005958	DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958)
0.0	0.2	GO:0030315	T-tubule(GO:0030315)
0.0	0.1	GO:0030127	COPII vesicle coat(GO:0030127)
0.0	0.2	GO:0016581	NuRD complex(GO:0016581) CHD-type complex(GO:0090545) nuclear transcriptional repressor complex(GO:0090568)
0.0	0.1	GO:0001527	microfibril(GO:0001527)
0.0	0.2	GO:0032420	stereocilium(GO:0032420)
0.0	0.1	GO:0031588	nucleotide-activated protein kinase complex(GO:0031588)
0.0	0.0	GO:0005589	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0	0.1	GO:0032389	MutLalpha complex(GO:0032389)
0.0	0.0	GO:0070545	PeBoW complex(GO:0070545)
0.0	0.1	GO:0042575	DNA polymerase complex(GO:0042575)
0.0	0.0	GO:0005751	mitochondrial respiratory chain complex IV(GO:0005751) respiratory chain complex IV(GO:0045277)
0.0	0.1	GO:0034045	pre-autophagosomal structure membrane(GO:0034045)
0.0	0.2	GO:0005811	lipid particle(GO:0005811)
0.0	0.1	GO:0000796	condensin complex(GO:0000796)
0.0	0.1	GO:0005952	cAMP-dependent protein kinase complex(GO:0005952)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0008510	sodium:bicarbonate symporter activity(GO:0008510)
0.1	0.2	GO:0016886	ligase activity, forming phosphoric ester bonds(GO:0016886)
0.0	0.2	GO:0047238	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.0	0.2	GO:0030284	estrogen receptor activity(GO:0030284)
0.0	0.2	GO:0005110	frizzled-2 binding(GO:0005110)
0.0	0.1	GO:0051371	muscle alpha-actinin binding(GO:0051371)
0.0	0.3	GO:0008195	phosphatidate phosphatase activity(GO:0008195)
0.0	0.1	GO:0000987	RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.0	0.1	GO:0004720	protein-lysine 6-oxidase activity(GO:0004720)
0.0	0.1	GO:0005030	neurotrophin receptor activity(GO:0005030)
0.0	0.1	GO:0033130	acetylcholine receptor binding(GO:0033130)
0.0	0.1	GO:0030297	transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.0	0.1	GO:0034237	protein kinase A regulatory subunit binding(GO:0034237)
0.0	0.1	GO:0004924	oncostatin-M receptor activity(GO:0004924)
0.0	0.1	GO:0004800	thyroxine 5'-deiodinase activity(GO:0004800)
0.0	0.1	GO:0015204	urea transmembrane transporter activity(GO:0015204)
0.0	0.1	GO:0004967	glucagon receptor activity(GO:0004967)
0.0	0.1	GO:0004157	dihydropyrimidinase activity(GO:0004157)
0.0	0.2	GO:0001968	fibronectin binding(GO:0001968)
0.0	0.1	GO:0017154	semaphorin receptor activity(GO:0017154)
0.0	0.1	GO:0042805	actinin binding(GO:0042805)
0.0	0.1	GO:0070052	collagen V binding(GO:0070052)
0.0	0.1	GO:0004862	cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0	0.3	GO:0005248	voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.0	0.0	GO:0048018	receptor agonist activity(GO:0048018)
0.0	0.2	GO:0030332	cyclin binding(GO:0030332)
0.0	0.2	GO:0051010	microtubule plus-end binding(GO:0051010)
0.0	0.1	GO:0015220	choline transmembrane transporter activity(GO:0015220)
0.0	0.1	GO:0050897	cobalt ion binding(GO:0050897)
0.0	0.1	GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.0	0.1	GO:0043237	laminin-1 binding(GO:0043237)
0.0	0.1	GO:0005042	netrin receptor activity(GO:0005042)
0.0	0.2	GO:0070411	I-SMAD binding(GO:0070411)
0.0	0.2	GO:0033613	activating transcription factor binding(GO:0033613)
0.0	0.1	GO:0030274	LIM domain binding(GO:0030274)
0.0	0.0	GO:0050510	N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510)
0.0	0.1	GO:0005522	profilin binding(GO:0005522)
0.0	0.1	GO:0005521	lamin binding(GO:0005521)
0.0	0.0	GO:0003987	acetate-CoA ligase activity(GO:0003987)
0.0	0.1	GO:0019237	centromeric DNA binding(GO:0019237)
0.0	0.0	GO:0034186	apolipoprotein A-I binding(GO:0034186)
0.0	0.1	GO:0008889	glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.0	0.1	GO:0005047	signal recognition particle binding(GO:0005047)
0.0	0.2	GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656)
0.0	0.0	GO:0004784	superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.0	0.2	GO:0005024	transforming growth factor beta-activated receptor activity(GO:0005024)
0.0	0.0	GO:0003836	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0	0.0	GO:0010485	H4 histone acetyltransferase activity(GO:0010485)
0.0	0.0	GO:0004127	cytidylate kinase activity(GO:0004127)
0.0	0.0	GO:0051880	G-quadruplex DNA binding(GO:0051880)
0.0	0.0	GO:0045545	syndecan binding(GO:0045545)
0.0	0.2	GO:0005247	voltage-gated chloride channel activity(GO:0005247)
0.0	0.0	GO:0015106	bicarbonate transmembrane transporter activity(GO:0015106)
0.0	0.1	GO:0003956	NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
0.0	0.1	GO:0035251	UDP-glucosyltransferase activity(GO:0035251)
0.0	0.0	GO:0042978	ornithine decarboxylase activator activity(GO:0042978)
0.0	0.0	GO:0005350	pyrimidine nucleobase transmembrane transporter activity(GO:0005350)
0.0	0.1	GO:0005111	type 2 fibroblast growth factor receptor binding(GO:0005111)
0.0	0.0	GO:0004117	calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.1	PID AVB3 OPN PATHWAY	Osteopontin-mediated events
0.1	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.1	SA TRKA RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.1	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.0	PID SHP2 PATHWAY	SHP2 signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.2	REACTOME SYNTHESIS OF PE	Genes involved in Synthesis of PE
0.3	REACTOME CRMPS IN SEMA3A SIGNALING	Genes involved in CRMPs in Sema3A signaling
0.1	REACTOME INTEGRATION OF PROVIRUS	Genes involved in Integration of provirus
0.0	REACTOME DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR	Genes involved in Downstream Signaling Events Of B Cell Receptor (BCR)
0.0	REACTOME REGULATION OF APOPTOSIS	Genes involved in Regulation of Apoptosis
0.0	REACTOME CTLA4 INHIBITORY SIGNALING	Genes involved in CTLA4 inhibitory signaling
0.0	REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN	Genes involved in Platelet Adhesion to exposed collagen
0.2	REACTOME RETROGRADE NEUROTROPHIN SIGNALLING	Genes involved in Retrograde neurotrophin signalling
0.1	REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA	Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.1	REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING	Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.2	REACTOME CHONDROITIN SULFATE BIOSYNTHESIS	Genes involved in Chondroitin sulfate biosynthesis
0.1	REACTOME ROLE OF DCC IN REGULATING APOPTOSIS	Genes involved in Role of DCC in regulating apoptosis
0.0	REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION	Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression