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ENCODE: H3K4me1 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for POU6F2

Z-value: 1.18

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Transcription factors associated with POU6F2

Gene Symbol	Gene ID	Gene Info
POU6F2 Ensembl NCBI GeneCards UniProt	ENSG00000106536.15	POU6F2

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
POU6F2	chr7_39015574_39015725	1949	0.390848	0.66	5.2e-02	Click!
POU6F2	chr7_39125520_39125671	134	0.976918	0.49	1.8e-01	Click!
POU6F2	chr7_39084738_39084889	10878	0.244307	0.40	2.9e-01	Click!
POU6F2	chr7_39108946_39109097	14140	0.255179	0.38	3.1e-01	Click!
POU6F2	chr7_39016018_39016169	1505	0.466358	-0.37	3.3e-01	Click!

Activity of the POU6F2 motif across conditions

Conditions sorted by the z-value of the POU6F2 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr16_88827167_88827318	0.61	RP5-1142A6.8		18013	0.07
chr2_143918611_143918880	0.56	RP11-190J23.1		10996	0.25
chr19_39686992_39687200	0.53	NCCRP1	non-specific cytotoxic cell receptor protein 1 homolog (zebrafish)	505	0.69
chr13_28191870_28192051	0.50	LNX2	ligand of numb-protein X 2	2581	0.28
chr8_100025991_100026384	0.49	VPS13B	vacuolar protein sorting 13 homolog B (yeast)	685	0.69
chr22_20226344_20226543	0.48	RTN4R	reticulon 4 receptor	4764	0.15
chr5_64919668_64919819	0.48	TRIM23	tripartite motif containing 23	380	0.59
chr18_54675278_54675477	0.47	WDR7-OT1	WDR7 overlapping transcript 1 (non-protein coding)	19686	0.2
chr2_148804260_148804811	0.46	ORC4	origin recognition complex, subunit 4	25388	0.19
chr3_42556058_42556209	0.44	VIPR1	vasoactive intestinal peptide receptor 1	12018	0.15
chr8_56797558_56797741	0.44	LYN	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	5255	0.16
chr13_50144464_50144942	0.43	RCBTB1	regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1	3244	0.28
chr14_75885514_75885665	0.42	RP11-293M10.6		8804	0.19
chr9_95484035_95484186	0.41	BICD2	bicaudal D homolog 2 (Drosophila)	42984	0.13
chr9_137251018_137251277	0.41	ENSG00000263897	.	20110	0.22
chr3_182951624_182951847	0.41	B3GNT5	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5	19297	0.18
chr7_29247042_29247209	0.41	AC004593.3		1461	0.41
chr11_60250640_60250791	0.41	MS4A12	membrane-spanning 4-domains, subfamily A, member 12	9536	0.16
chr3_69508401_69508552	0.39	FRMD4B	FERM domain containing 4B	73046	0.13
chr8_75912287_75912438	0.39	CRISPLD1	cysteine-rich secretory protein LCCL domain containing 1	27	0.98
chr17_72460689_72460840	0.38	CD300A	CD300a molecule	1791	0.28
chr11_108108099_108108300	0.38	ENSG00000206967	.	7868	0.16
chr1_155910079_155910230	0.38	RXFP4	relaxin/insulin-like family peptide receptor 4	1326	0.24
chr7_105713236_105713439	0.38	SYPL1	synaptophysin-like 1	24971	0.22
chr6_163672536_163672884	0.37	ENSG00000239136	.	24768	0.23
chr1_151019823_151020083	0.37	C1orf56	chromosome 1 open reading frame 56	263	0.81
chr3_127541043_127541283	0.37	MGLL	monoglyceride lipase	31	0.98
chr10_17269926_17270077	0.36	VIM	vimentin	257	0.85
chr6_109778792_109779119	0.35	MICAL1	microtubule associated monooxygenase, calponin and LIM domain containing 1	1765	0.23
chr8_96160918_96161069	0.35	PLEKHF2	pleckstrin homology domain containing, family F (with FYVE domain) member 2	14689	0.21
chr8_28827953_28828104	0.35	HMBOX1	homeobox containing 1	6648	0.19
chr2_152510948_152511099	0.35	NEB	nebulin	70890	0.13
chr15_86018767_86019073	0.35	AKAP13	A kinase (PRKA) anchor protein 13	68351	0.1
chr10_106094941_106095155	0.35	ITPRIP	inositol 1,4,5-trisphosphate receptor interacting protein	1385	0.33
chr17_28275117_28275440	0.34	EFCAB5	EF-hand calcium binding domain 5	6655	0.17
chr2_74798667_74798834	0.34	LOXL3	lysyl oxidase-like 3	15933	0.09
chr6_37023862_37024242	0.34	COX6A1P2	cytochrome c oxidase subunit VIa polypeptide 1 pseudogene 2	11445	0.2
chr5_40384915_40385167	0.34	ENSG00000265615	.	64621	0.14
chr3_119750375_119750629	0.34	GSK3B	glycogen synthase kinase 3 beta	62011	0.12
chr11_130818062_130818213	0.33	SNX19	sorting nexin 19	31733	0.21
chr16_57467574_57467725	0.33	CIAPIN1	cytokine induced apoptosis inhibitor 1	7238	0.13
chr3_5234609_5235124	0.33	EDEM1	ER degradation enhancer, mannosidase alpha-like 1	4832	0.17
chr10_102989164_102989315	0.33	LBX1-AS1	LBX1 antisense RNA 1 (head to head)	112	0.75
chr14_61814414_61814719	0.33	PRKCH	protein kinase C, eta	43	0.98
chr1_223276536_223276687	0.33	TLR5	toll-like receptor 5	31487	0.23
chr1_192775939_192776107	0.33	RGS2	regulator of G-protein signaling 2, 24kDa	2148	0.41
chr5_143521997_143522238	0.32	ENSG00000239390	.	1673	0.41
chr1_113383632_113383813	0.32	SLC16A1	solute carrier family 16 (monocarboxylate transporter), member 1	94888	0.06
chr20_49167545_49167829	0.32	ENSG00000239742	.	6848	0.14
chr1_160645057_160645403	0.32	RP11-404F10.2		1918	0.29
chr5_171382567_171382718	0.32	FBXW11	F-box and WD repeat domain containing 11	22118	0.23
chr19_33783274_33783425	0.31	CTD-2540B15.11		7491	0.13
chr15_64092651_64092802	0.31	HERC1	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1	33358	0.18
chr16_67618812_67618963	0.31	CTCF	CCCTC-binding factor (zinc finger protein)	22577	0.08
chr1_178695749_178695999	0.31	RP11-428K3.1		454	0.74
chr20_11896789_11896970	0.31	BTBD3	BTB (POZ) domain containing 3	1686	0.39
chr3_40270824_40271123	0.31	ENSG00000202517	.	9126	0.22
chr4_41937652_41937803	0.30	TMEM33	transmembrane protein 33	558	0.81
chr2_152382467_152382626	0.30	NEB	nebulin	46	0.99
chr12_54686387_54686538	0.30	NFE2	nuclear factor, erythroid 2	3080	0.11
chr6_14129461_14129612	0.30	CD83	CD83 molecule	11664	0.25
chr2_218258190_218258341	0.30	ENSG00000251982	.	141986	0.05
chr11_77222826_77223151	0.30	PAK1	p21 protein (Cdc42/Rac)-activated kinase 1	37308	0.13
chr21_27530840_27531046	0.30	AP001439.2		534	0.8
chr6_143214487_143214638	0.30	HIVEP2	human immunodeficiency virus type I enhancer binding protein 2	51776	0.16
chr12_80355505_80355656	0.30	PPP1R12A	protein phosphatase 1, regulatory subunit 12A	26340	0.18
chr10_135077834_135078056	0.30	ADAM8	ADAM metallopeptidase domain 8	12409	0.1
chr2_230932339_230932574	0.29	SLC16A14	solute carrier family 16, member 14	549	0.76
chr11_82781868_82782128	0.29	RAB30	RAB30, member RAS oncogene family	872	0.59
chr6_117804732_117805043	0.29	DCBLD1	discoidin, CUB and LCCL domain containing 1	1062	0.49
chr6_3379208_3379367	0.29	SLC22A23	solute carrier family 22, member 23	60365	0.12
chr12_117472876_117473027	0.29	TESC	tescalcin	11685	0.24
chr19_36632480_36632690	0.29	CAPNS1	calpain, small subunit 1	90	0.93
chr1_28797868_28798297	0.29	ENSG00000221216	.	9792	0.12
chr10_63494099_63494250	0.29	RP11-63A2.2		49028	0.16
chrX_129243328_129243479	0.29	ELF4	E74-like factor 4 (ets domain transcription factor)	933	0.6
chr3_56908949_56909100	0.29	ARHGEF3	Rho guanine nucleotide exchange factor (GEF) 3	41475	0.18
chr5_141095035_141095247	0.29	ARAP3	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3	33353	0.13
chr6_13178010_13178161	0.29	PHACTR1	phosphatase and actin regulator 1	4666	0.27
chr3_112218706_112219142	0.29	BTLA	B and T lymphocyte associated	516	0.83
chr17_36875186_36875337	0.29	ENSG00000266632	.	683	0.34
chr1_247124558_247124714	0.29	AHCTF1	AT hook containing transcription factor 1	29356	0.17
chr7_150635354_150635936	0.29	KCNH2	potassium voltage-gated channel, subfamily H (eag-related), member 2	17349	0.15
chr2_135438010_135438325	0.29	TMEM163	transmembrane protein 163	38403	0.21
chr17_56454718_56454869	0.29	SUPT4H1	suppressor of Ty 4 homolog 1 (S. cerevisiae)	24339	0.1
chrX_148577496_148577647	0.28	IDS	iduronate 2-sulfatase	5687	0.2
chr3_196008048_196008327	0.28	PCYT1A	phosphate cytidylyltransferase 1, choline, alpha	5947	0.13
chr11_65560041_65560192	0.28	OVOL1	ovo-like zinc finger 1	1064	0.29
chr10_14921644_14922279	0.28	SUV39H2	suppressor of variegation 3-9 homolog 2 (Drosophila)	146	0.96
chr10_45559099_45559250	0.28	RSU1P2	Ras suppressor protein 1 pseudogene 2	52375	0.1
chr20_40203312_40203463	0.28	CHD6	chromodomain helicase DNA binding protein 6	40025	0.19
chr10_35617439_35617590	0.28	RP11-324I22.4		7588	0.2
chr19_48251684_48251835	0.28	GLTSCR2	glioma tumor suppressor candidate region gene 2	1676	0.25
chr10_8225559_8225769	0.28	GATA3	GATA binding protein 3	128895	0.06
chr10_70756923_70757083	0.28	KIAA1279	KIAA1279	8516	0.17
chr6_108500284_108500435	0.28	NR2E1	nuclear receptor subfamily 2, group E, member 1	10392	0.17
chr16_28157963_28158114	0.28	XPO6	exportin 6	23184	0.16
chr6_53512892_53513248	0.28	KLHL31	kelch-like family member 31	7000	0.2
chr11_21437319_21437470	0.27	ENSG00000252816	.	31939	0.25
chr18_7572621_7572772	0.27	PTPRM	protein tyrosine phosphatase, receptor type, M	4879	0.33
chr8_128410350_128410501	0.27	POU5F1B	POU class 5 homeobox 1B	16110	0.24
chr7_1958177_1958328	0.27	MAD1L1	MAD1 mitotic arrest deficient-like 1 (yeast)	21933	0.21
chr6_15481650_15481973	0.27	DTNBP1	dystrobrevin binding protein 1	66782	0.12
chr14_90767940_90768091	0.27	NRDE2	NRDE-2, necessary for RNA interference, domain containing	1166	0.54
chr11_27494130_27494448	0.27	LGR4	leucine-rich repeat containing G protein-coupled receptor 4	4	0.95
chr3_55658753_55658990	0.27	WNT5A	wingless-type MMTV integration site family, member 5A	134898	0.05
chr5_40486236_40486671	0.27	ENSG00000265615	.	166033	0.03
chr7_44499545_44500008	0.27	NUDCD3	NudC domain containing 3	30703	0.16
chr17_47786040_47786409	0.27	SLC35B1	solute carrier family 35, member B1	152	0.82
chr2_24576972_24577263	0.27	ITSN2	intersectin 2	6061	0.25
chr9_133535744_133535959	0.27	PRDM12	PR domain containing 12	4130	0.24
chr1_193092667_193092853	0.26	CDC73	cell division cycle 73	1613	0.3
chr7_1443816_1444071	0.26	MICALL2	MICAL-like 2	55019	0.11
chr8_67562699_67562850	0.26	ENSG00000201365	.	2930	0.19
chr3_3842833_3843133	0.26	LRRN1	leucine rich repeat neuronal 1	1862	0.51
chr10_28664504_28664655	0.26	ENSG00000222666	.	32601	0.16
chr19_18811650_18811905	0.26	CRTC1	CREB regulated transcription coactivator 1	17289	0.14
chr8_679831_680617	0.26	ERICH1	glutamate-rich 1	973	0.56
chr22_43524391_43524692	0.26	MCAT	malonyl CoA:ACP acyltransferase (mitochondrial)	14429	0.13
chr3_185463575_185463764	0.26	ENSG00000265470	.	22023	0.19
chr2_110665948_110666142	0.26	LIMS3	LIM and senescent cell antigen-like domains 3	9777	0.28
chr4_75550360_75550586	0.26	AC142293.3		35809	0.18
chr7_30779658_30779809	0.26	INMT	indolethylamine N-methyltransferase	12018	0.18
chr12_72240351_72240502	0.26	TBC1D15	TBC1 domain family, member 15	6868	0.27
chr2_159955686_159955837	0.26	ENSG00000202029	.	72107	0.11
chr15_59815756_59816014	0.26	ENSG00000201704	.	50536	0.1
chr16_30887666_30887829	0.26	MIR4519	microRNA 4519	514	0.52
chr6_63067792_63067943	0.26	KHDRBS2	KH domain containing, RNA binding, signal transduction associated 2	71735	0.14
chr4_26271298_26271607	0.26	RBPJ	recombination signal binding protein for immunoglobulin kappa J region	2777	0.42
chr7_87986652_87986803	0.26	STEAP4	STEAP family member 4	50521	0.15
chr7_134921673_134921883	0.26	STRA8	stimulated by retinoic acid 8	5047	0.19
chr2_220222755_220222906	0.26	RESP18	regulated endocrine-specific protein 18	24931	0.08
chr17_29625776_29625927	0.25	OMG	oligodendrocyte myelin glycoprotein	1422	0.33
chr4_128619641_128619792	0.25	INTU	inturned planar cell polarity protein	10747	0.23
chr18_57585553_57585704	0.25	PMAIP1	phorbol-12-myristate-13-acetate-induced protein 1	18380	0.23
chr1_185066313_185066464	0.25	TRMT1L	tRNA methyltransferase 1 homolog (S. cerevisiae)-like	42304	0.13
chr7_140064792_140064943	0.25	SLC37A3	solute carrier family 37, member 3	4587	0.15
chr1_35322341_35322540	0.25	SMIM12	small integral membrane protein 12	2206	0.23
chr5_53815191_53815729	0.25	SNX18	sorting nexin 18	1867	0.46
chr1_17379040_17379191	0.25	SDHB	succinate dehydrogenase complex, subunit B, iron sulfur (Ip)	1550	0.37
chr6_47010736_47010893	0.25	GPR110	G protein-coupled receptor 110	715	0.78
chr1_54517100_54517585	0.25	TMEM59	transmembrane protein 59	1523	0.25
chr1_156032386_156032537	0.25	RAB25	RAB25, member RAS oncogene family	1510	0.21
chr21_43150775_43150926	0.25	AP001615.9		8683	0.18
chr8_87534571_87534756	0.25	CPNE3	copine III	6628	0.21
chr5_134914716_134914867	0.25	CXCL14	chemokine (C-X-C motif) ligand 14	37	0.55
chr7_50425191_50425522	0.25	IKZF1	IKAROS family zinc finger 1 (Ikaros)	58111	0.13
chr20_31238150_31238301	0.25	RP11-410N8.4		48786	0.11
chr2_120156492_120156643	0.25	TMEM37	transmembrane protein 37	30910	0.14
chr4_53517593_53517744	0.25	USP46	ubiquitin specific peptidase 46	5089	0.23
chr12_94568571_94568722	0.25	RP11-74K11.2		1534	0.43
chr20_32438083_32438241	0.25	CHMP4B	charged multivesicular body protein 4B	39052	0.13
chr1_207226034_207226222	0.25	YOD1	YOD1 deubiquitinase	197	0.75
chr5_138942637_138942977	0.25	UBE2D2	ubiquitin-conjugating enzyme E2D 2	1193	0.45
chr9_134579612_134579763	0.25	RAPGEF1	Rap guanine nucleotide exchange factor (GEF) 1	5542	0.24
chr13_99867467_99867663	0.24	ENSG00000201793	.	9603	0.19
chr7_36678667_36679209	0.24	ENSG00000221561	.	2911	0.3
chr6_73334747_73334898	0.24	KCNQ5	potassium voltage-gated channel, KQT-like subfamily, member 5	2904	0.32
chr17_47600778_47600929	0.24	NGFR	nerve growth factor receptor	26100	0.12
chr1_178102702_178103151	0.24	RASAL2	RAS protein activator like 2	39650	0.22
chr12_104613249_104613462	0.24	TXNRD1	thioredoxin reductase 1	3796	0.26
chr7_156826274_156826425	0.24	MNX1-AS1	MNX1 antisense RNA 1 (head to head)	22850	0.15
chr2_120621924_120622075	0.24	ENSG00000238368	.	52895	0.14
chr11_102140256_102140407	0.24	RP11-864G5.3		38678	0.13
chr5_8456418_8456569	0.24	ENSG00000247516	.	4545	0.37
chr9_127030175_127030580	0.24	RP11-121A14.3		5222	0.19
chr5_136899227_136899378	0.24	ENSG00000221612	.	30159	0.2
chr4_102075262_102075413	0.24	ENSG00000221265	.	176234	0.03
chr4_100869365_100869729	0.24	RP11-15B17.1		1616	0.26
chr6_43637939_43638090	0.24	MRPS18A	mitochondrial ribosomal protein S18A	17514	0.12
chr19_4404320_4404471	0.24	CHAF1A	chromatin assembly factor 1, subunit A (p150)	1681	0.17
chr15_51915534_51915836	0.24	DMXL2	Dmx-like 2	655	0.7
chr4_89580349_89580582	0.24	HERC3	HECT and RLD domain containing E3 ubiquitin protein ligase 3	1046	0.51
chr14_97991006_97991157	0.24	ENSG00000240730	.	5429	0.35
chr10_30720160_30720460	0.24	MAP3K8	mitogen-activated protein kinase kinase kinase 8	2556	0.31
chr2_187559059_187559451	0.24	FAM171B	family with sequence similarity 171, member B	557	0.55
chr16_84769322_84769473	0.24	USP10	ubiquitin specific peptidase 10	32474	0.16
chr4_38531154_38531351	0.24	RP11-617D20.1		94944	0.08
chr6_3750232_3750480	0.24	RP11-420L9.5		989	0.52
chr9_84298176_84298387	0.24	TLE1	transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)	4002	0.3
chr10_71530651_71530802	0.24	COL13A1	collagen, type XIII, alpha 1	30918	0.17
chr4_41486518_41486669	0.24	LIMCH1	LIM and calponin homology domains 1	53581	0.16
chr2_159315078_159315280	0.23	PKP4	plakophilin 4	1555	0.33
chr9_80359497_80359648	0.23	GNAQ	guanine nucleotide binding protein (G protein), q polypeptide	78343	0.1
chr12_12009079_12009249	0.23	ETV6	ets variant 6	29707	0.24
chr6_35271134_35271285	0.23	DEF6	differentially expressed in FDCP 6 homolog (mouse)	5580	0.2
chr6_10079647_10079798	0.23	OFCC1	orofacial cleft 1 candidate 1	35285	0.23
chr2_42891438_42891589	0.23	ENSG00000194270	.	26412	0.19
chr5_56205875_56206117	0.23	SETD9	SET domain containing 9	64	0.89
chr2_26232303_26232586	0.23	AC013449.1	Uncharacterized protein	19037	0.15
chr11_67170134_67170292	0.23	PPP1CA	protein phosphatase 1, catalytic subunit, alpha isozyme	811	0.3
chrX_30646272_30646423	0.23	GK	glycerol kinase	25129	0.17
chr10_48355678_48355829	0.23	ZNF488	zinc finger protein 488	652	0.61
chr3_135909805_135909961	0.23	MSL2	male-specific lethal 2 homolog (Drosophila)	3513	0.32
chr9_127526848_127527031	0.23	RP11-175D17.3		5463	0.15
chr2_135001433_135001641	0.23	MGAT5	mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase	10293	0.24
chr17_37964816_37964967	0.23	IKZF3	IKAROS family zinc finger 3 (Aiolos)	30413	0.12
chr3_111848709_111848860	0.23	GCSAM	germinal center-associated, signaling and motility	3288	0.2
chr2_192623976_192624127	0.23	AC098872.3		34100	0.19
chr1_169029691_169029842	0.23	ENSG00000252987	.	6736	0.21

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of POU6F2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0034219	carbohydrate transmembrane transport(GO:0034219)
0.1	0.2	GO:0006667	sphinganine metabolic process(GO:0006667)
0.1	0.2	GO:0002430	complement receptor mediated signaling pathway(GO:0002430)
0.1	0.2	GO:0030011	maintenance of cell polarity(GO:0030011)
0.1	0.2	GO:0002693	positive regulation of cellular extravasation(GO:0002693)
0.1	0.2	GO:0019532	oxalate transport(GO:0019532)
0.1	0.2	GO:0006003	fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.1	0.2	GO:0060510	lung saccule development(GO:0060430) Type II pneumocyte differentiation(GO:0060510)
0.0	0.1	GO:0006106	fumarate metabolic process(GO:0006106)
0.0	0.1	GO:0030948	negative regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030948)
0.0	0.1	GO:2000380	regulation of mesodermal cell fate specification(GO:0042661) regulation of mesoderm development(GO:2000380)
0.0	0.2	GO:0007021	tubulin complex assembly(GO:0007021)
0.0	0.2	GO:0060159	regulation of dopamine receptor signaling pathway(GO:0060159)
0.0	0.2	GO:0071731	response to nitric oxide(GO:0071731)
0.0	0.5	GO:0019369	arachidonic acid metabolic process(GO:0019369)
0.0	0.2	GO:0048096	chromatin-mediated maintenance of transcription(GO:0048096)
0.0	0.1	GO:0007095	mitotic G2 DNA damage checkpoint(GO:0007095)
0.0	0.1	GO:0048714	positive regulation of oligodendrocyte differentiation(GO:0048714)
0.0	0.1	GO:0060054	positive regulation of epithelial cell proliferation involved in wound healing(GO:0060054)
0.0	0.2	GO:0005981	regulation of glycogen catabolic process(GO:0005981)
0.0	0.1	GO:0051152	positive regulation of smooth muscle cell differentiation(GO:0051152)
0.0	0.2	GO:0001866	NK T cell proliferation(GO:0001866)
0.0	0.1	GO:0052169	pathogen-associated molecular pattern dependent induction by symbiont of host innate immune response(GO:0052033) positive regulation by symbiont of host innate immune response(GO:0052166) modulation by symbiont of host innate immune response(GO:0052167) pathogen-associated molecular pattern dependent modulation by symbiont of host innate immune response(GO:0052169) pathogen-associated molecular pattern dependent induction by organism of innate immune response of other organism involved in symbiotic interaction(GO:0052257) positive regulation by organism of innate immune response in other organism involved in symbiotic interaction(GO:0052305) modulation by organism of innate immune response in other organism involved in symbiotic interaction(GO:0052306) pathogen-associated molecular pattern dependent modulation by organism of innate immune response in other organism involved in symbiotic interaction(GO:0052308)
0.0	0.3	GO:0061647	histone H3-K9 methylation(GO:0051567) histone H3-K9 modification(GO:0061647)
0.0	0.1	GO:0043312	neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312)
0.0	0.0	GO:0060061	Spemann organizer formation(GO:0060061)
0.0	0.1	GO:0032713	negative regulation of interleukin-4 production(GO:0032713)
0.0	0.1	GO:0006167	AMP biosynthetic process(GO:0006167)
0.0	0.3	GO:0071108	protein K48-linked deubiquitination(GO:0071108)
0.0	0.3	GO:0007172	signal complex assembly(GO:0007172)
0.0	0.3	GO:0018216	peptidyl-arginine methylation(GO:0018216)
0.0	0.1	GO:0003308	negative regulation of Wnt signaling pathway involved in heart development(GO:0003308)
0.0	0.1	GO:0071072	negative regulation of phospholipid biosynthetic process(GO:0071072)
0.0	0.1	GO:0060206	estrous cycle phase(GO:0060206)
0.0	0.1	GO:0070561	vitamin D receptor signaling pathway(GO:0070561)
0.0	0.1	GO:0006269	DNA replication, synthesis of RNA primer(GO:0006269)
0.0	0.1	GO:0002513	tolerance induction to self antigen(GO:0002513)
0.0	0.0	GO:0010980	regulation of vitamin D 24-hydroxylase activity(GO:0010979) positive regulation of vitamin D 24-hydroxylase activity(GO:0010980)
0.0	0.1	GO:2000114	regulation of establishment of cell polarity(GO:2000114)
0.0	0.1	GO:0000103	sulfate assimilation(GO:0000103)
0.0	0.1	GO:0046642	negative regulation of alpha-beta T cell proliferation(GO:0046642)
0.0	0.1	GO:0046033	AMP metabolic process(GO:0046033)
0.0	0.1	GO:0046322	negative regulation of fatty acid oxidation(GO:0046322)
0.0	0.1	GO:0009786	regulation of asymmetric cell division(GO:0009786)
0.0	0.2	GO:0070189	kynurenine metabolic process(GO:0070189)
0.0	0.2	GO:0045109	intermediate filament organization(GO:0045109)
0.0	0.2	GO:0048668	collateral sprouting(GO:0048668)
0.0	0.1	GO:0015825	L-serine transport(GO:0015825)
0.0	0.1	GO:0022417	protein maturation by protein folding(GO:0022417)
0.0	0.1	GO:0060528	secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.0	0.1	GO:0010508	positive regulation of autophagy(GO:0010508)
0.0	0.1	GO:0008354	germ cell migration(GO:0008354)
0.0	0.1	GO:0060743	epithelial cell maturation involved in prostate gland development(GO:0060743)
0.0	0.1	GO:0032927	positive regulation of activin receptor signaling pathway(GO:0032927)
0.0	0.1	GO:0032790	ribosome disassembly(GO:0032790)
0.0	0.1	GO:0001821	histamine secretion(GO:0001821)
0.0	0.0	GO:0046931	pore complex assembly(GO:0046931)
0.0	0.1	GO:0006552	leucine catabolic process(GO:0006552)
0.0	0.1	GO:0032060	bleb assembly(GO:0032060)
0.0	0.0	GO:0002282	microglial cell activation involved in immune response(GO:0002282)
0.0	0.1	GO:0051775	response to redox state(GO:0051775)
0.0	0.1	GO:0042921	glucocorticoid receptor signaling pathway(GO:0042921)
0.0	0.1	GO:0060907	positive regulation of macrophage cytokine production(GO:0060907)
0.0	0.9	GO:0030049	muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)
0.0	0.1	GO:0042447	hormone catabolic process(GO:0042447)
0.0	0.1	GO:0072393	microtubule anchoring at microtubule organizing center(GO:0072393)
0.0	0.2	GO:0045749	obsolete negative regulation of S phase of mitotic cell cycle(GO:0045749)
0.0	0.2	GO:0007185	transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0	0.1	GO:0007256	activation of JNKK activity(GO:0007256)
0.0	0.0	GO:0031935	regulation of chromatin silencing(GO:0031935) negative regulation of chromatin silencing(GO:0031936)
0.0	0.1	GO:0009235	cobalamin metabolic process(GO:0009235)
0.0	0.0	GO:0010459	negative regulation of heart rate(GO:0010459)
0.0	0.2	GO:0050858	negative regulation of antigen receptor-mediated signaling pathway(GO:0050858) negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0	0.1	GO:0060762	regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
0.0	0.1	GO:0006975	DNA damage induced protein phosphorylation(GO:0006975)
0.0	0.0	GO:0001672	regulation of chromatin assembly or disassembly(GO:0001672)
0.0	0.0	GO:0034723	DNA replication-dependent nucleosome organization(GO:0034723)
0.0	0.1	GO:0060633	negative regulation of transcription initiation from RNA polymerase II promoter(GO:0060633) negative regulation of DNA-templated transcription, initiation(GO:2000143)
0.0	0.1	GO:0034755	iron ion transmembrane transport(GO:0034755)
0.0	0.1	GO:0002085	inhibition of neuroepithelial cell differentiation(GO:0002085)
0.0	0.0	GO:0033147	negative regulation of intracellular estrogen receptor signaling pathway(GO:0033147)
0.0	0.0	GO:0002713	negative regulation of B cell mediated immunity(GO:0002713) negative regulation of immunoglobulin mediated immune response(GO:0002890)
0.0	0.1	GO:0060539	diaphragm development(GO:0060539)
0.0	0.0	GO:0007144	female meiosis I(GO:0007144)
0.0	0.1	GO:1904358	positive regulation of telomere maintenance via telomerase(GO:0032212) positive regulation of telomere maintenance via telomere lengthening(GO:1904358)
0.0	0.1	GO:0000239	pachytene(GO:0000239)
0.0	0.1	GO:0031340	positive regulation of vesicle fusion(GO:0031340)
0.0	0.4	GO:0006471	protein ADP-ribosylation(GO:0006471)
0.0	0.0	GO:0001661	conditioned taste aversion(GO:0001661)
0.0	0.1	GO:0060292	long term synaptic depression(GO:0060292)
0.0	0.0	GO:0001831	trophectodermal cellular morphogenesis(GO:0001831)
0.0	0.1	GO:0001973	adenosine receptor signaling pathway(GO:0001973) G-protein coupled purinergic receptor signaling pathway(GO:0035588)
0.0	0.0	GO:0042747	circadian sleep/wake cycle, REM sleep(GO:0042747)
0.0	0.1	GO:0032070	regulation of deoxyribonuclease activity(GO:0032070)
0.0	0.1	GO:0019852	L-ascorbic acid metabolic process(GO:0019852)
0.0	0.1	GO:0006048	UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.0	0.1	GO:0043320	natural killer cell activation involved in immune response(GO:0002323) natural killer cell degranulation(GO:0043320)
0.0	0.1	GO:0043923	positive regulation by host of viral transcription(GO:0043923)
0.0	0.1	GO:0015781	pyrimidine nucleotide-sugar transport(GO:0015781)
0.0	0.0	GO:0060242	contact inhibition(GO:0060242)
0.0	0.1	GO:0032455	nerve growth factor processing(GO:0032455)
0.0	0.1	GO:0034453	microtubule anchoring(GO:0034453)
0.0	0.1	GO:0006654	phosphatidic acid biosynthetic process(GO:0006654)
0.0	0.1	GO:2000095	regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000095)
0.0	0.1	GO:0018342	protein prenylation(GO:0018342) prenylation(GO:0097354)
0.0	0.1	GO:1901722	regulation of cell proliferation involved in kidney development(GO:1901722)
0.0	0.0	GO:0034145	positive regulation of toll-like receptor 4 signaling pathway(GO:0034145)
0.0	0.1	GO:0019987	obsolete negative regulation of anti-apoptosis(GO:0019987)
0.0	0.1	GO:0043441	acetoacetic acid biosynthetic process(GO:0043441)
0.0	0.1	GO:0048664	neuron fate determination(GO:0048664)
0.0	0.1	GO:0006703	estrogen biosynthetic process(GO:0006703)
0.0	0.1	GO:0043568	positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568)
0.0	0.1	GO:0031573	intra-S DNA damage checkpoint(GO:0031573)
0.0	0.1	GO:0051788	response to misfolded protein(GO:0051788)
0.0	0.1	GO:0032781	positive regulation of ATPase activity(GO:0032781)
0.0	0.2	GO:0016577	histone demethylation(GO:0016577)
0.0	0.1	GO:0090205	positive regulation of cholesterol metabolic process(GO:0090205)
0.0	0.1	GO:0042753	positive regulation of circadian rhythm(GO:0042753)
0.0	0.1	GO:0018106	peptidyl-histidine phosphorylation(GO:0018106)
0.0	0.0	GO:0008356	asymmetric cell division(GO:0008356)
0.0	0.0	GO:0060164	regulation of timing of neuron differentiation(GO:0060164)
0.0	0.1	GO:0051014	actin filament severing(GO:0051014)
0.0	0.0	GO:0048312	intracellular distribution of mitochondria(GO:0048312)
0.0	0.1	GO:0060123	regulation of growth hormone secretion(GO:0060123)
0.0	0.0	GO:0006556	S-adenosylmethionine biosynthetic process(GO:0006556)
0.0	0.0	GO:0010701	positive regulation of norepinephrine secretion(GO:0010701)
0.0	0.0	GO:0016576	histone dephosphorylation(GO:0016576)
0.0	0.0	GO:0070634	transepithelial ammonium transport(GO:0070634)
0.0	0.0	GO:0030952	establishment or maintenance of cytoskeleton polarity(GO:0030952)
0.0	0.1	GO:0051965	positive regulation of synapse assembly(GO:0051965)
0.0	0.0	GO:0072194	kidney smooth muscle tissue development(GO:0072194)
0.0	0.0	GO:0045836	positive regulation of meiotic nuclear division(GO:0045836) positive regulation of meiotic cell cycle(GO:0051446)
0.0	0.1	GO:0045945	positive regulation of transcription from RNA polymerase III promoter(GO:0045945)
0.0	0.0	GO:0060684	epithelial-mesenchymal cell signaling(GO:0060684)
0.0	0.0	GO:0071921	establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
0.0	0.0	GO:0009405	pathogenesis(GO:0009405)
0.0	0.0	GO:2000330	T-helper cell lineage commitment(GO:0002295) CD4-positive, alpha-beta T cell lineage commitment(GO:0043373) memory T cell differentiation(GO:0043379) regulation of memory T cell differentiation(GO:0043380) positive regulation of memory T cell differentiation(GO:0043382) T-helper 17 type immune response(GO:0072538) T-helper 17 cell differentiation(GO:0072539) T-helper 17 cell lineage commitment(GO:0072540) regulation of T-helper 17 type immune response(GO:2000316) positive regulation of T-helper 17 type immune response(GO:2000318) regulation of T-helper 17 cell differentiation(GO:2000319) positive regulation of T-helper 17 cell differentiation(GO:2000321) regulation of T-helper 17 cell lineage commitment(GO:2000328) positive regulation of T-helper 17 cell lineage commitment(GO:2000330)
0.0	0.1	GO:0048713	regulation of oligodendrocyte differentiation(GO:0048713) negative regulation of oligodendrocyte differentiation(GO:0048715)
0.0	0.0	GO:0022614	membrane to membrane docking(GO:0022614)
0.0	0.1	GO:0034587	piRNA metabolic process(GO:0034587)
0.0	0.0	GO:0014012	peripheral nervous system axon regeneration(GO:0014012)
0.0	0.0	GO:0006686	sphingomyelin biosynthetic process(GO:0006686)
0.0	0.1	GO:0035162	embryonic hemopoiesis(GO:0035162)
0.0	0.0	GO:0048496	maintenance of organ identity(GO:0048496)
0.0	0.0	GO:0007412	axon target recognition(GO:0007412)
0.0	0.0	GO:0060235	lens induction in camera-type eye(GO:0060235)
0.0	0.3	GO:0030010	establishment of cell polarity(GO:0030010)
0.0	0.1	GO:0040037	negative regulation of fibroblast growth factor receptor signaling pathway(GO:0040037)
0.0	0.0	GO:0008214	protein demethylation(GO:0006482) protein dealkylation(GO:0008214)
0.0	0.0	GO:0007181	transforming growth factor beta receptor complex assembly(GO:0007181)
0.0	0.0	GO:0006189	'de novo' IMP biosynthetic process(GO:0006189)
0.0	0.0	GO:1903332	regulation of protein folding(GO:1903332)
0.0	0.1	GO:0007258	JUN phosphorylation(GO:0007258)
0.0	0.1	GO:0048821	erythrocyte development(GO:0048821) myeloid cell development(GO:0061515)
0.0	0.1	GO:0045662	negative regulation of myoblast differentiation(GO:0045662)
0.0	0.1	GO:0043392	negative regulation of DNA binding(GO:0043392)
0.0	0.0	GO:0045162	clustering of voltage-gated sodium channels(GO:0045162)
0.0	0.0	GO:0002363	alpha-beta T cell lineage commitment(GO:0002363) CD4-positive or CD8-positive, alpha-beta T cell lineage commitment(GO:0043369)
0.0	0.1	GO:0033523	histone H2B ubiquitination(GO:0033523)
0.0	0.1	GO:0045410	positive regulation of interleukin-6 biosynthetic process(GO:0045410)
0.0	0.1	GO:0007090	obsolete regulation of S phase of mitotic cell cycle(GO:0007090)
0.0	0.1	GO:0043984	histone H4-K16 acetylation(GO:0043984)
0.0	0.1	GO:0070207	protein homotrimerization(GO:0070207)
0.0	0.1	GO:0006491	N-glycan processing(GO:0006491)
0.0	0.1	GO:0035020	regulation of Rac protein signal transduction(GO:0035020)
0.0	0.1	GO:0006828	manganese ion transport(GO:0006828)
0.0	0.1	GO:0002052	positive regulation of neuroblast proliferation(GO:0002052)
0.0	0.0	GO:0032516	positive regulation of phosphoprotein phosphatase activity(GO:0032516)
0.0	0.1	GO:0018195	peptidyl-arginine modification(GO:0018195)
0.0	0.0	GO:0060219	camera-type eye photoreceptor cell differentiation(GO:0060219)
0.0	0.3	GO:0006099	tricarboxylic acid cycle(GO:0006099)
0.0	0.0	GO:2000403	T cell chemotaxis(GO:0010818) regulation of T cell chemotaxis(GO:0010819) positive regulation of T cell chemotaxis(GO:0010820) regulation of lymphocyte chemotaxis(GO:1901623) regulation of lymphocyte migration(GO:2000401) positive regulation of lymphocyte migration(GO:2000403) regulation of T cell migration(GO:2000404) positive regulation of T cell migration(GO:2000406)
0.0	0.1	GO:0016973	poly(A)+ mRNA export from nucleus(GO:0016973)
0.0	0.0	GO:0045091	regulation of single stranded viral RNA replication via double stranded DNA intermediate(GO:0045091)
0.0	0.0	GO:0045986	negative regulation of smooth muscle contraction(GO:0045986)
0.0	0.0	GO:0002523	leukocyte migration involved in inflammatory response(GO:0002523)
0.0	0.0	GO:0033622	integrin activation(GO:0033622)
0.0	0.1	GO:0015793	glycerol transport(GO:0015793)
0.0	0.0	GO:0048548	regulation of pinocytosis(GO:0048548)
0.0	0.0	GO:0035455	response to interferon-alpha(GO:0035455)
0.0	0.1	GO:0010591	regulation of lamellipodium assembly(GO:0010591) regulation of lamellipodium organization(GO:1902743)
0.0	0.0	GO:0032905	transforming growth factor beta1 production(GO:0032905) regulation of transforming growth factor beta1 production(GO:0032908) positive regulation of transforming growth factor beta1 production(GO:0032914)
0.0	0.1	GO:0006072	glycerol-3-phosphate metabolic process(GO:0006072)
0.0	0.0	GO:0003093	regulation of glomerular filtration(GO:0003093) glomerular filtration(GO:0003094) renal filtration(GO:0097205) regulation of renal system process(GO:0098801)
0.0	0.1	GO:0031268	pseudopodium organization(GO:0031268)
0.0	0.0	GO:0050774	negative regulation of dendrite morphogenesis(GO:0050774)
0.0	0.1	GO:0042149	cellular response to glucose starvation(GO:0042149)
0.0	0.0	GO:0043653	mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.0	0.0	GO:0002331	pre-B cell allelic exclusion(GO:0002331)
0.0	0.0	GO:0006216	cytidine catabolic process(GO:0006216) cytidine deamination(GO:0009972) cytidine metabolic process(GO:0046087)
0.0	0.0	GO:0017121	phospholipid scrambling(GO:0017121)
0.0	0.0	GO:0002495	antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.0	0.0	GO:0050872	white fat cell differentiation(GO:0050872)
0.0	0.0	GO:0019934	cGMP-mediated signaling(GO:0019934)
0.0	0.0	GO:0071549	cellular response to dexamethasone stimulus(GO:0071549)
0.0	0.0	GO:0006295	nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295)
0.0	0.0	GO:0008053	mitochondrial fusion(GO:0008053)
0.0	0.0	GO:1901655	cellular response to ketone(GO:1901655)
0.0	0.1	GO:0071285	cellular response to lithium ion(GO:0071285)
0.0	0.0	GO:0010587	miRNA metabolic process(GO:0010586) miRNA catabolic process(GO:0010587)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0002178	palmitoyltransferase complex(GO:0002178) serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0	0.2	GO:0042587	glycogen granule(GO:0042587)
0.0	0.1	GO:0070022	transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0	0.1	GO:0000791	euchromatin(GO:0000791)
0.0	0.1	GO:0042405	nuclear inclusion body(GO:0042405)
0.0	0.1	GO:0000138	Golgi trans cisterna(GO:0000138)
0.0	0.1	GO:0031235	intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0	0.2	GO:0005678	obsolete chromatin assembly complex(GO:0005678)
0.0	0.2	GO:0030121	AP-1 adaptor complex(GO:0030121)
0.0	0.1	GO:0045281	mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.0	0.5	GO:0005720	nuclear heterochromatin(GO:0005720)
0.0	0.1	GO:0060201	clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201)
0.0	0.2	GO:0016461	unconventional myosin complex(GO:0016461)
0.0	0.1	GO:0032777	Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0	0.4	GO:0016514	SWI/SNF complex(GO:0016514)
0.0	0.1	GO:0072487	MSL complex(GO:0072487)
0.0	0.2	GO:0045239	tricarboxylic acid cycle enzyme complex(GO:0045239)
0.0	0.2	GO:0046581	intercellular canaliculus(GO:0046581)
0.0	0.1	GO:0016593	Cdc73/Paf1 complex(GO:0016593)
0.0	0.2	GO:0005845	mRNA cap binding complex(GO:0005845) RNA cap binding complex(GO:0034518)
0.0	0.1	GO:0005658	alpha DNA polymerase:primase complex(GO:0005658)
0.0	0.1	GO:0070552	BRISC complex(GO:0070552)
0.0	0.1	GO:0042788	polysomal ribosome(GO:0042788)
0.0	0.1	GO:0031045	dense core granule(GO:0031045)
0.0	0.1	GO:0031265	CD95 death-inducing signaling complex(GO:0031265)
0.0	0.2	GO:0005844	polysome(GO:0005844)
0.0	0.1	GO:0005853	eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0	0.1	GO:0001740	Barr body(GO:0001740)
0.0	0.0	GO:0042584	chromaffin granule(GO:0042583) chromaffin granule membrane(GO:0042584)
0.0	0.7	GO:0008287	protein serine/threonine phosphatase complex(GO:0008287) phosphatase complex(GO:1903293)
0.0	0.0	GO:0043240	Fanconi anaemia nuclear complex(GO:0043240)
0.0	0.0	GO:0044298	neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0	0.0	GO:0031932	TORC2 complex(GO:0031932)
0.0	0.1	GO:0042581	specific granule(GO:0042581)
0.0	0.0	GO:0030008	TRAPP complex(GO:0030008)
0.0	0.6	GO:0015030	Cajal body(GO:0015030)
0.0	0.0	GO:0070062	extracellular exosome(GO:0070062) extracellular vesicle(GO:1903561)
0.0	0.1	GO:0031082	BLOC complex(GO:0031082) BLOC-1 complex(GO:0031083)
0.0	0.0	GO:0048179	activin receptor complex(GO:0048179)
0.0	0.1	GO:0031143	pseudopodium(GO:0031143)
0.0	0.1	GO:0051233	spindle midzone(GO:0051233)
0.0	0.0	GO:0043625	delta DNA polymerase complex(GO:0043625)
0.0	0.1	GO:0005652	nuclear lamina(GO:0005652)
0.0	0.2	GO:0030530	obsolete heterogeneous nuclear ribonucleoprotein complex(GO:0030530)
0.0	0.5	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0	0.0	GO:0005827	polar microtubule(GO:0005827)
0.0	0.1	GO:0001891	phagocytic cup(GO:0001891)
0.0	0.1	GO:0000780	condensed nuclear chromosome, centromeric region(GO:0000780)
0.0	0.1	GO:0031254	uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0	0.2	GO:0000178	exosome (RNase complex)(GO:0000178)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0004758	serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.1	0.2	GO:0019834	phospholipase A2 inhibitor activity(GO:0019834)
0.1	0.2	GO:0004875	complement receptor activity(GO:0004875)
0.1	0.5	GO:0047372	acylglycerol lipase activity(GO:0047372)
0.1	0.3	GO:0046974	histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.1	0.2	GO:0019531	oxalate transmembrane transporter activity(GO:0019531)
0.1	0.2	GO:0008109	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.1	0.2	GO:0003873	6-phosphofructo-2-kinase activity(GO:0003873)
0.1	0.3	GO:0015165	pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.1	0.4	GO:0004908	interleukin-1 receptor activity(GO:0004908)
0.0	0.1	GO:0036137	kynurenine-oxoglutarate transaminase activity(GO:0016212) kynurenine aminotransferase activity(GO:0036137)
0.0	0.1	GO:0003896	DNA primase activity(GO:0003896)
0.0	0.2	GO:0004982	N-formyl peptide receptor activity(GO:0004982)
0.0	0.2	GO:0003945	N-acetyllactosamine synthase activity(GO:0003945)
0.0	0.1	GO:0008545	JUN kinase kinase activity(GO:0008545)
0.0	0.2	GO:0008266	poly(U) RNA binding(GO:0008266)
0.0	0.1	GO:0070644	vitamin D response element binding(GO:0070644)
0.0	0.1	GO:0048039	ubiquinone binding(GO:0048039)
0.0	0.1	GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.0	0.1	GO:0005094	Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0	0.3	GO:0016273	arginine N-methyltransferase activity(GO:0016273) protein-arginine N-methyltransferase activity(GO:0016274)
0.0	0.1	GO:0008190	eukaryotic initiation factor 4E binding(GO:0008190)
0.0	0.1	GO:0032139	dinucleotide insertion or deletion binding(GO:0032139)
0.0	0.1	GO:0042910	xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.0	0.1	GO:0004949	cannabinoid receptor activity(GO:0004949)
0.0	0.1	GO:0022889	L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.0	0.3	GO:0016500	protein-hormone receptor activity(GO:0016500)
0.0	0.2	GO:0070087	chromo shadow domain binding(GO:0070087)
0.0	0.2	GO:0001671	ATPase activator activity(GO:0001671)
0.0	0.2	GO:0004691	cAMP-dependent protein kinase activity(GO:0004691)
0.0	0.1	GO:0004999	vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.0	0.3	GO:0004198	calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0	0.1	GO:0017056	structural constituent of nuclear pore(GO:0017056)
0.0	0.1	GO:0003986	acetyl-CoA hydrolase activity(GO:0003986)
0.0	0.1	GO:0016421	CoA carboxylase activity(GO:0016421)
0.0	0.1	GO:0005381	iron ion transmembrane transporter activity(GO:0005381)
0.0	0.1	GO:0005010	insulin-like growth factor-activated receptor activity(GO:0005010)
0.0	0.1	GO:0004904	interferon receptor activity(GO:0004904)
0.0	0.1	GO:0004083	bisphosphoglycerate mutase activity(GO:0004082) bisphosphoglycerate 2-phosphatase activity(GO:0004083) phosphoglycerate mutase activity(GO:0004619)
0.0	0.1	GO:0008475	procollagen-lysine 5-dioxygenase activity(GO:0008475)
0.0	0.1	GO:0003985	acetyl-CoA C-acetyltransferase activity(GO:0003985)
0.0	0.1	GO:0005049	nuclear export signal receptor activity(GO:0005049)
0.0	0.5	GO:0019003	GDP binding(GO:0019003)
0.0	0.1	GO:0003828	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0	0.1	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.0	0.1	GO:0070579	methylcytosine dioxygenase activity(GO:0070579)
0.0	0.3	GO:0004697	protein kinase C activity(GO:0004697)
0.0	0.1	GO:0045236	CXCR chemokine receptor binding(GO:0045236)
0.0	0.1	GO:0016909	JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0	0.1	GO:0004340	glucokinase activity(GO:0004340)
0.0	0.2	GO:0051787	misfolded protein binding(GO:0051787)
0.0	0.1	GO:0043125	ErbB-3 class receptor binding(GO:0043125)
0.0	0.1	GO:0034584	piRNA binding(GO:0034584)
0.0	0.8	GO:0004722	protein serine/threonine phosphatase activity(GO:0004722)
0.0	0.2	GO:0099604	calcium-release channel activity(GO:0015278) ligand-gated calcium channel activity(GO:0099604)
0.0	0.1	GO:0004591	oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.0	0.2	GO:0016493	C-C chemokine receptor activity(GO:0016493)
0.0	0.1	GO:0016309	1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0	0.1	GO:0015038	glutathione disulfide oxidoreductase activity(GO:0015038)
0.0	0.1	GO:0008318	protein prenyltransferase activity(GO:0008318)
0.0	0.1	GO:0005384	manganese ion transmembrane transporter activity(GO:0005384)
0.0	0.1	GO:0030911	TPR domain binding(GO:0030911)
0.0	0.1	GO:0051425	PTB domain binding(GO:0051425)
0.0	0.1	GO:0005007	fibroblast growth factor-activated receptor activity(GO:0005007)
0.0	0.1	GO:0016842	amidine-lyase activity(GO:0016842)
0.0	0.2	GO:0004303	estradiol 17-beta-dehydrogenase activity(GO:0004303)
0.0	0.0	GO:0008107	galactoside 2-alpha-L-fucosyltransferase activity(GO:0008107) alpha-(1,2)-fucosyltransferase activity(GO:0031127)
0.0	0.0	GO:0070643	vitamin D3 25-hydroxylase activity(GO:0030343) vitamin D 25-hydroxylase activity(GO:0070643)
0.0	0.0	GO:0002060	purine nucleobase binding(GO:0002060)
0.0	0.1	GO:0005087	Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.0	0.1	GO:0042043	neurexin family protein binding(GO:0042043)
0.0	0.0	GO:0047623	AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0	0.1	GO:0070577	lysine-acetylated histone binding(GO:0070577)
0.0	0.0	GO:0030375	thyroid hormone receptor coactivator activity(GO:0030375)
0.0	0.2	GO:0004707	MAP kinase activity(GO:0004707)
0.0	0.0	GO:0005134	interleukin-2 receptor binding(GO:0005134)
0.0	0.1	GO:0001784	phosphotyrosine binding(GO:0001784)
0.0	0.1	GO:0008140	cAMP response element binding protein binding(GO:0008140)
0.0	0.0	GO:0004677	DNA-dependent protein kinase activity(GO:0004677)
0.0	0.1	GO:0043024	ribosomal small subunit binding(GO:0043024)
0.0	0.1	GO:0004749	ribose phosphate diphosphokinase activity(GO:0004749)
0.0	0.1	GO:0004862	cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0	0.0	GO:0046404	ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734)
0.0	0.1	GO:0070290	N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0	0.1	GO:0004185	serine-type carboxypeptidase activity(GO:0004185)
0.0	0.0	GO:0030306	ADP-ribosylation factor binding(GO:0030306)
0.0	0.1	GO:0004957	prostaglandin E receptor activity(GO:0004957)
0.0	0.2	GO:0048365	Rac GTPase binding(GO:0048365)
0.0	0.1	GO:0019788	NEDD8 transferase activity(GO:0019788)
0.0	0.0	GO:0043515	kinetochore binding(GO:0043515)
0.0	0.1	GO:0000828	inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832)
0.0	0.1	GO:0032454	histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0	0.1	GO:0048027	mRNA 5'-UTR binding(GO:0048027)
0.0	0.2	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0	0.1	GO:0001595	angiotensin receptor activity(GO:0001595) angiotensin type II receptor activity(GO:0004945)
0.0	0.0	GO:0000309	nicotinamide-nucleotide adenylyltransferase activity(GO:0000309) nicotinate-nucleotide adenylyltransferase activity(GO:0004515)
0.0	0.1	GO:0005149	interleukin-1 receptor binding(GO:0005149)
0.0	0.1	GO:0070567	cytidylyltransferase activity(GO:0070567)
0.0	0.1	GO:0003688	DNA replication origin binding(GO:0003688)
0.0	0.1	GO:0070053	thrombospondin receptor activity(GO:0070053)
0.0	0.0	GO:0000064	L-ornithine transmembrane transporter activity(GO:0000064)
0.0	0.0	GO:0000268	peroxisome targeting sequence binding(GO:0000268)
0.0	0.2	GO:0070566	adenylyltransferase activity(GO:0070566)
0.0	0.3	GO:0030295	protein kinase activator activity(GO:0030295)
0.0	0.0	GO:0047499	calcium-independent phospholipase A2 activity(GO:0047499)
0.0	0.0	GO:0042608	T cell receptor binding(GO:0042608)
0.0	0.1	GO:0031702	type 1 angiotensin receptor binding(GO:0031702)
0.0	0.3	GO:0008186	RNA-dependent ATPase activity(GO:0008186)
0.0	0.1	GO:0050998	nitric-oxide synthase binding(GO:0050998)
0.0	0.0	GO:0004370	glycerol kinase activity(GO:0004370)
0.0	0.1	GO:0016416	carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.0	0.1	GO:0015924	mannosyl-oligosaccharide mannosidase activity(GO:0015924)
0.0	0.1	GO:0004668	protein-arginine deiminase activity(GO:0004668)
0.0	0.0	GO:0034236	protein kinase A catalytic subunit binding(GO:0034236)
0.0	0.0	GO:0015254	glycerol channel activity(GO:0015254)
0.0	0.1	GO:0000339	RNA cap binding(GO:0000339)
0.0	0.0	GO:0098847	single-stranded telomeric DNA binding(GO:0043047) sequence-specific single stranded DNA binding(GO:0098847)
0.0	0.0	GO:0004062	aryl sulfotransferase activity(GO:0004062)
0.0	0.0	GO:0004939	beta-adrenergic receptor activity(GO:0004939)
0.0	0.2	GO:0019894	kinesin binding(GO:0019894)
0.0	0.0	GO:0003857	3-hydroxyacyl-CoA dehydrogenase activity(GO:0003857)
0.0	0.0	GO:0004594	pantothenate kinase activity(GO:0004594)
0.0	0.1	GO:0004128	cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.0	0.1	GO:0004703	G-protein coupled receptor kinase activity(GO:0004703)
0.0	0.1	GO:0005161	platelet-derived growth factor receptor binding(GO:0005161)
0.0	0.1	GO:0008242	omega peptidase activity(GO:0008242)
0.0	0.0	GO:0017089	glycolipid transporter activity(GO:0017089)
0.0	0.5	GO:0008307	structural constituent of muscle(GO:0008307)
0.0	0.1	GO:0031419	cobalamin binding(GO:0031419)
0.0	0.3	GO:0017137	Rab GTPase binding(GO:0017137)
0.0	0.1	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0	0.1	GO:0005123	death receptor binding(GO:0005123)
0.0	0.0	GO:0032137	guanine/thymine mispair binding(GO:0032137)
0.0	0.1	GO:0030159	receptor signaling complex scaffold activity(GO:0030159)
0.0	0.1	GO:0005112	Notch binding(GO:0005112)
0.0	0.0	GO:0030898	actin-dependent ATPase activity(GO:0030898)
0.0	0.1	GO:0048019	receptor antagonist activity(GO:0048019)
0.0	0.1	GO:0016565	obsolete general transcriptional repressor activity(GO:0016565)
0.0	0.0	GO:0004477	methenyltetrahydrofolate cyclohydrolase activity(GO:0004477)
0.0	0.1	GO:0005031	tumor necrosis factor-activated receptor activity(GO:0005031)
0.0	0.1	GO:0004614	phosphoglucomutase activity(GO:0004614)
0.0	0.1	GO:0008159	obsolete positive transcription elongation factor activity(GO:0008159)
0.0	0.0	GO:0017128	phospholipid scramblase activity(GO:0017128)
0.0	0.0	GO:0016149	translation release factor activity, codon specific(GO:0016149)
0.0	0.0	GO:0008607	phosphorylase kinase regulator activity(GO:0008607)
0.0	0.0	GO:0004465	lipoprotein lipase activity(GO:0004465)
0.0	0.1	GO:0017075	syntaxin-1 binding(GO:0017075)
0.0	0.1	GO:0016174	NAD(P)H oxidase activity(GO:0016174)
0.0	0.0	GO:0004774	succinate-CoA ligase activity(GO:0004774)
0.0	0.0	GO:0031628	opioid receptor binding(GO:0031628)
0.0	0.2	GO:0050699	WW domain binding(GO:0050699)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.1	PID ECADHERIN KERATINOCYTE PATHWAY	E-cadherin signaling in keratinocytes
0.0	PID GLYPICAN 1PATHWAY	Glypican 1 network
0.3	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.1	ST PAC1 RECEPTOR PATHWAY	PAC1 Receptor Pathway
0.4	ST TUMOR NECROSIS FACTOR PATHWAY	Tumor Necrosis Factor Pathway.
0.0	ST IL 13 PATHWAY	Interleukin 13 (IL-13) Pathway
0.6	PID CASPASE PATHWAY	Caspase cascade in apoptosis
0.1	PID IL5 PATHWAY	IL5-mediated signaling events
0.2	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.1	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.1	ST GAQ PATHWAY	G alpha q Pathway
0.4	PID IL8 CXCR2 PATHWAY	IL8- and CXCR2-mediated signaling events
0.5	PID NFAT 3PATHWAY	Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.1	PID PI3KCI AKT PATHWAY	Class I PI3K signaling events mediated by Akt
0.3	PID IL1 PATHWAY	IL1-mediated signaling events
0.1	PID FAS PATHWAY	FAS (CD95) signaling pathway
0.1	PID PI3K PLC TRK PATHWAY	Trk receptor signaling mediated by PI3K and PLC-gamma
0.2	PID CERAMIDE PATHWAY	Ceramide signaling pathway
0.0	PID ANGIOPOIETIN RECEPTOR PATHWAY	Angiopoietin receptor Tie2-mediated signaling
0.1	PID ERB GENOMIC PATHWAY	Validated nuclear estrogen receptor beta network
0.1	PID IGF1 PATHWAY	IGF1 pathway
0.1	SA TRKA RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.5	PID AR TF PATHWAY	Regulation of Androgen receptor activity
0.2	PID ALK1 PATHWAY	ALK1 signaling events
0.1	PID SYNDECAN 2 PATHWAY	Syndecan-2-mediated signaling events
0.3	PID ARF6 PATHWAY	Arf6 signaling events
0.0	ST G ALPHA S PATHWAY	G alpha s Pathway
0.2	PID THROMBIN PAR1 PATHWAY	PAR1-mediated thrombin signaling events
0.4	PID MET PATHWAY	Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.1	PID ERBB1 RECEPTOR PROXIMAL PATHWAY	EGF receptor (ErbB1) signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.1	REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	Genes involved in DCC mediated attractive signaling
0.1	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION	Genes involved in TRAF6 mediated IRF7 activation
0.5	REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS	Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0	REACTOME TRIGLYCERIDE BIOSYNTHESIS	Genes involved in Triglyceride Biosynthesis
0.1	REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES	Genes involved in p75NTR recruits signalling complexes
0.7	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.1	REACTOME G PROTEIN BETA GAMMA SIGNALLING	Genes involved in G-protein beta:gamma signalling
0.1	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.3	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.4	REACTOME CITRIC ACID CYCLE TCA CYCLE	Genes involved in Citric acid cycle (TCA cycle)
0.0	REACTOME TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS	Genes involved in TGF-beta receptor signaling activates SMADs
0.3	REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING	Genes involved in Downregulation of TGF-beta receptor signaling
0.2	REACTOME TRYPTOPHAN CATABOLISM	Genes involved in Tryptophan catabolism
0.2	REACTOME ACTIVATION OF RAC	Genes involved in Activation of Rac
0.2	REACTOME POL SWITCHING	Genes involved in Polymerase switching
0.2	REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.1	REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS	Genes involved in Activation of the AP-1 family of transcription factors
0.2	REACTOME NOD1 2 SIGNALING PATHWAY	Genes involved in NOD1/2 Signaling Pathway
0.1	REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS	Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.2	REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM	Genes involved in Branched-chain amino acid catabolism
0.1	REACTOME MTORC1 MEDIATED SIGNALLING	Genes involved in mTORC1-mediated signalling
0.1	REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.1	REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR	Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.3	REACTOME RORA ACTIVATES CIRCADIAN EXPRESSION	Genes involved in RORA Activates Circadian Expression
0.5	REACTOME IL1 SIGNALING	Genes involved in Interleukin-1 signaling
0.2	REACTOME TRAF6 MEDIATED NFKB ACTIVATION	Genes involved in TRAF6 mediated NF-kB activation
0.2	REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY	Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.2	REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS	Genes involved in Synthesis of substrates in N-glycan biosythesis
0.2	REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION	Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.1	REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION	Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.1	REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES	Genes involved in Cytosolic sulfonation of small molecules
0.1	REACTOME PRE NOTCH PROCESSING IN GOLGI	Genes involved in Pre-NOTCH Processing in Golgi
0.1	REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS	Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0	REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI	Genes involved in RIP-mediated NFkB activation via DAI
0.2	REACTOME SIGNALING BY FGFR1 FUSION MUTANTS	Genes involved in Signaling by FGFR1 fusion mutants
0.2	REACTOME TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3 SMAD4 HETEROTRIMER	Genes involved in Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
0.5	REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S	Genes involved in Activation of Chaperone Genes by XBP1(S)
0.2	REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS	Genes involved in Homologous recombination repair of replication-independent double-strand breaks