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ENCODE: H3K4me1 ChIP-Seq of primary human cells
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Results for POU6F2

Z-value: 1.18

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Transcription factors associated with POU6F2

Gene Symbol Gene ID Gene Info
ENSG00000106536.15 POU class 6 homeobox 2

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr7_39015574_39015725POU6F219490.3908480.665.2e-02Click!
chr7_39125520_39125671POU6F21340.9769180.491.8e-01Click!
chr7_39084738_39084889POU6F2108780.2443070.402.9e-01Click!
chr7_39108946_39109097POU6F2141400.2551790.383.1e-01Click!
chr7_39016018_39016169POU6F215050.466358-0.373.3e-01Click!

Activity of the POU6F2 motif across conditions

Conditions sorted by the z-value of the POU6F2 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr16_88827167_88827318 0.61 RP5-1142A6.8

18013
0.07
chr2_143918611_143918880 0.56 RP11-190J23.1

10996
0.25
chr19_39686992_39687200 0.53 NCCRP1
non-specific cytotoxic cell receptor protein 1 homolog (zebrafish)
505
0.69
chr13_28191870_28192051 0.50 LNX2
ligand of numb-protein X 2
2581
0.28
chr8_100025991_100026384 0.49 VPS13B
vacuolar protein sorting 13 homolog B (yeast)
685
0.69
chr22_20226344_20226543 0.48 RTN4R
reticulon 4 receptor
4764
0.15
chr5_64919668_64919819 0.48 TRIM23
tripartite motif containing 23
380
0.59
chr18_54675278_54675477 0.47 WDR7-OT1
WDR7 overlapping transcript 1 (non-protein coding)
19686
0.2
chr2_148804260_148804811 0.46 ORC4
origin recognition complex, subunit 4
25388
0.19
chr3_42556058_42556209 0.44 VIPR1
vasoactive intestinal peptide receptor 1
12018
0.15
chr8_56797558_56797741 0.44 LYN
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
5255
0.16
chr13_50144464_50144942 0.43 RCBTB1
regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1
3244
0.28
chr14_75885514_75885665 0.42 RP11-293M10.6

8804
0.19
chr9_95484035_95484186 0.41 BICD2
bicaudal D homolog 2 (Drosophila)
42984
0.13
chr9_137251018_137251277 0.41 ENSG00000263897
.
20110
0.22
chr3_182951624_182951847 0.41 B3GNT5
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
19297
0.18
chr7_29247042_29247209 0.41 AC004593.3

1461
0.41
chr11_60250640_60250791 0.41 MS4A12
membrane-spanning 4-domains, subfamily A, member 12
9536
0.16
chr3_69508401_69508552 0.39 FRMD4B
FERM domain containing 4B
73046
0.13
chr8_75912287_75912438 0.39 CRISPLD1
cysteine-rich secretory protein LCCL domain containing 1
27
0.98
chr17_72460689_72460840 0.38 CD300A
CD300a molecule
1791
0.28
chr11_108108099_108108300 0.38 ENSG00000206967
.
7868
0.16
chr1_155910079_155910230 0.38 RXFP4
relaxin/insulin-like family peptide receptor 4
1326
0.24
chr7_105713236_105713439 0.38 SYPL1
synaptophysin-like 1
24971
0.22
chr6_163672536_163672884 0.37 ENSG00000239136
.
24768
0.23
chr1_151019823_151020083 0.37 C1orf56
chromosome 1 open reading frame 56
263
0.81
chr3_127541043_127541283 0.37 MGLL
monoglyceride lipase
31
0.98
chr10_17269926_17270077 0.36 VIM
vimentin
257
0.85
chr6_109778792_109779119 0.35 MICAL1
microtubule associated monooxygenase, calponin and LIM domain containing 1
1765
0.23
chr8_96160918_96161069 0.35 PLEKHF2
pleckstrin homology domain containing, family F (with FYVE domain) member 2
14689
0.21
chr8_28827953_28828104 0.35 HMBOX1
homeobox containing 1
6648
0.19
chr2_152510948_152511099 0.35 NEB
nebulin
70890
0.13
chr15_86018767_86019073 0.35 AKAP13
A kinase (PRKA) anchor protein 13
68351
0.1
chr10_106094941_106095155 0.35 ITPRIP
inositol 1,4,5-trisphosphate receptor interacting protein
1385
0.33
chr17_28275117_28275440 0.34 EFCAB5
EF-hand calcium binding domain 5
6655
0.17
chr2_74798667_74798834 0.34 LOXL3
lysyl oxidase-like 3
15933
0.09
chr6_37023862_37024242 0.34 COX6A1P2
cytochrome c oxidase subunit VIa polypeptide 1 pseudogene 2
11445
0.2
chr5_40384915_40385167 0.34 ENSG00000265615
.
64621
0.14
chr3_119750375_119750629 0.34 GSK3B
glycogen synthase kinase 3 beta
62011
0.12
chr11_130818062_130818213 0.33 SNX19
sorting nexin 19
31733
0.21
chr16_57467574_57467725 0.33 CIAPIN1
cytokine induced apoptosis inhibitor 1
7238
0.13
chr3_5234609_5235124 0.33 EDEM1
ER degradation enhancer, mannosidase alpha-like 1
4832
0.17
chr10_102989164_102989315 0.33 LBX1-AS1
LBX1 antisense RNA 1 (head to head)
112
0.75
chr14_61814414_61814719 0.33 PRKCH
protein kinase C, eta
43
0.98
chr1_223276536_223276687 0.33 TLR5
toll-like receptor 5
31487
0.23
chr1_192775939_192776107 0.33 RGS2
regulator of G-protein signaling 2, 24kDa
2148
0.41
chr5_143521997_143522238 0.32 ENSG00000239390
.
1673
0.41
chr1_113383632_113383813 0.32 SLC16A1
solute carrier family 16 (monocarboxylate transporter), member 1
94888
0.06
chr20_49167545_49167829 0.32 ENSG00000239742
.
6848
0.14
chr1_160645057_160645403 0.32 RP11-404F10.2

1918
0.29
chr5_171382567_171382718 0.32 FBXW11
F-box and WD repeat domain containing 11
22118
0.23
chr19_33783274_33783425 0.31 CTD-2540B15.11

7491
0.13
chr15_64092651_64092802 0.31 HERC1
HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
33358
0.18
chr16_67618812_67618963 0.31 CTCF
CCCTC-binding factor (zinc finger protein)
22577
0.08
chr1_178695749_178695999 0.31 RP11-428K3.1

454
0.74
chr20_11896789_11896970 0.31 BTBD3
BTB (POZ) domain containing 3
1686
0.39
chr3_40270824_40271123 0.31 ENSG00000202517
.
9126
0.22
chr4_41937652_41937803 0.30 TMEM33
transmembrane protein 33
558
0.81
chr2_152382467_152382626 0.30 NEB
nebulin
46
0.99
chr12_54686387_54686538 0.30 NFE2
nuclear factor, erythroid 2
3080
0.11
chr6_14129461_14129612 0.30 CD83
CD83 molecule
11664
0.25
chr2_218258190_218258341 0.30 ENSG00000251982
.
141986
0.05
chr11_77222826_77223151 0.30 PAK1
p21 protein (Cdc42/Rac)-activated kinase 1
37308
0.13
chr21_27530840_27531046 0.30 AP001439.2

534
0.8
chr6_143214487_143214638 0.30 HIVEP2
human immunodeficiency virus type I enhancer binding protein 2
51776
0.16
chr12_80355505_80355656 0.30 PPP1R12A
protein phosphatase 1, regulatory subunit 12A
26340
0.18
chr10_135077834_135078056 0.30 ADAM8
ADAM metallopeptidase domain 8
12409
0.1
chr2_230932339_230932574 0.29 SLC16A14
solute carrier family 16, member 14
549
0.76
chr11_82781868_82782128 0.29 RAB30
RAB30, member RAS oncogene family
872
0.59
chr6_117804732_117805043 0.29 DCBLD1
discoidin, CUB and LCCL domain containing 1
1062
0.49
chr6_3379208_3379367 0.29 SLC22A23
solute carrier family 22, member 23
60365
0.12
chr12_117472876_117473027 0.29 TESC
tescalcin
11685
0.24
chr19_36632480_36632690 0.29 CAPNS1
calpain, small subunit 1
90
0.93
chr1_28797868_28798297 0.29 ENSG00000221216
.
9792
0.12
chr10_63494099_63494250 0.29 RP11-63A2.2

49028
0.16
chrX_129243328_129243479 0.29 ELF4
E74-like factor 4 (ets domain transcription factor)
933
0.6
chr3_56908949_56909100 0.29 ARHGEF3
Rho guanine nucleotide exchange factor (GEF) 3
41475
0.18
chr5_141095035_141095247 0.29 ARAP3
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
33353
0.13
chr6_13178010_13178161 0.29 PHACTR1
phosphatase and actin regulator 1
4666
0.27
chr3_112218706_112219142 0.29 BTLA
B and T lymphocyte associated
516
0.83
chr17_36875186_36875337 0.29 ENSG00000266632
.
683
0.34
chr1_247124558_247124714 0.29 AHCTF1
AT hook containing transcription factor 1
29356
0.17
chr7_150635354_150635936 0.29 KCNH2
potassium voltage-gated channel, subfamily H (eag-related), member 2
17349
0.15
chr2_135438010_135438325 0.29 TMEM163
transmembrane protein 163
38403
0.21
chr17_56454718_56454869 0.29 SUPT4H1
suppressor of Ty 4 homolog 1 (S. cerevisiae)
24339
0.1
chrX_148577496_148577647 0.28 IDS
iduronate 2-sulfatase
5687
0.2
chr3_196008048_196008327 0.28 PCYT1A
phosphate cytidylyltransferase 1, choline, alpha
5947
0.13
chr11_65560041_65560192 0.28 OVOL1
ovo-like zinc finger 1
1064
0.29
chr10_14921644_14922279 0.28 SUV39H2
suppressor of variegation 3-9 homolog 2 (Drosophila)
146
0.96
chr10_45559099_45559250 0.28 RSU1P2
Ras suppressor protein 1 pseudogene 2
52375
0.1
chr20_40203312_40203463 0.28 CHD6
chromodomain helicase DNA binding protein 6
40025
0.19
chr10_35617439_35617590 0.28 RP11-324I22.4

7588
0.2
chr19_48251684_48251835 0.28 GLTSCR2
glioma tumor suppressor candidate region gene 2
1676
0.25
chr10_8225559_8225769 0.28 GATA3
GATA binding protein 3
128895
0.06
chr10_70756923_70757083 0.28 KIAA1279
KIAA1279
8516
0.17
chr6_108500284_108500435 0.28 NR2E1
nuclear receptor subfamily 2, group E, member 1
10392
0.17
chr16_28157963_28158114 0.28 XPO6
exportin 6
23184
0.16
chr6_53512892_53513248 0.28 KLHL31
kelch-like family member 31
7000
0.2
chr11_21437319_21437470 0.27 ENSG00000252816
.
31939
0.25
chr18_7572621_7572772 0.27 PTPRM
protein tyrosine phosphatase, receptor type, M
4879
0.33
chr8_128410350_128410501 0.27 POU5F1B
POU class 5 homeobox 1B
16110
0.24
chr7_1958177_1958328 0.27 MAD1L1
MAD1 mitotic arrest deficient-like 1 (yeast)
21933
0.21
chr6_15481650_15481973 0.27 DTNBP1
dystrobrevin binding protein 1
66782
0.12
chr14_90767940_90768091 0.27 NRDE2
NRDE-2, necessary for RNA interference, domain containing
1166
0.54
chr11_27494130_27494448 0.27 LGR4
leucine-rich repeat containing G protein-coupled receptor 4
4
0.95
chr3_55658753_55658990 0.27 WNT5A
wingless-type MMTV integration site family, member 5A
134898
0.05
chr5_40486236_40486671 0.27 ENSG00000265615
.
166033
0.03
chr7_44499545_44500008 0.27 NUDCD3
NudC domain containing 3
30703
0.16
chr17_47786040_47786409 0.27 SLC35B1
solute carrier family 35, member B1
152
0.82
chr2_24576972_24577263 0.27 ITSN2
intersectin 2
6061
0.25
chr9_133535744_133535959 0.27 PRDM12
PR domain containing 12
4130
0.24
chr1_193092667_193092853 0.26 CDC73
cell division cycle 73
1613
0.3
chr7_1443816_1444071 0.26 MICALL2
MICAL-like 2
55019
0.11
chr8_67562699_67562850 0.26 ENSG00000201365
.
2930
0.19
chr3_3842833_3843133 0.26 LRRN1
leucine rich repeat neuronal 1
1862
0.51
chr10_28664504_28664655 0.26 ENSG00000222666
.
32601
0.16
chr19_18811650_18811905 0.26 CRTC1
CREB regulated transcription coactivator 1
17289
0.14
chr8_679831_680617 0.26 ERICH1
glutamate-rich 1
973
0.56
chr22_43524391_43524692 0.26 MCAT
malonyl CoA:ACP acyltransferase (mitochondrial)
14429
0.13
chr3_185463575_185463764 0.26 ENSG00000265470
.
22023
0.19
chr2_110665948_110666142 0.26 LIMS3
LIM and senescent cell antigen-like domains 3
9777
0.28
chr4_75550360_75550586 0.26 AC142293.3

35809
0.18
chr7_30779658_30779809 0.26 INMT
indolethylamine N-methyltransferase
12018
0.18
chr12_72240351_72240502 0.26 TBC1D15
TBC1 domain family, member 15
6868
0.27
chr2_159955686_159955837 0.26 ENSG00000202029
.
72107
0.11
chr15_59815756_59816014 0.26 ENSG00000201704
.
50536
0.1
chr16_30887666_30887829 0.26 MIR4519
microRNA 4519
514
0.52
chr6_63067792_63067943 0.26 KHDRBS2
KH domain containing, RNA binding, signal transduction associated 2
71735
0.14
chr4_26271298_26271607 0.26 RBPJ
recombination signal binding protein for immunoglobulin kappa J region
2777
0.42
chr7_87986652_87986803 0.26 STEAP4
STEAP family member 4
50521
0.15
chr7_134921673_134921883 0.26 STRA8
stimulated by retinoic acid 8
5047
0.19
chr2_220222755_220222906 0.26 RESP18
regulated endocrine-specific protein 18
24931
0.08
chr17_29625776_29625927 0.25 OMG
oligodendrocyte myelin glycoprotein
1422
0.33
chr4_128619641_128619792 0.25 INTU
inturned planar cell polarity protein
10747
0.23
chr18_57585553_57585704 0.25 PMAIP1
phorbol-12-myristate-13-acetate-induced protein 1
18380
0.23
chr1_185066313_185066464 0.25 TRMT1L
tRNA methyltransferase 1 homolog (S. cerevisiae)-like
42304
0.13
chr7_140064792_140064943 0.25 SLC37A3
solute carrier family 37, member 3
4587
0.15
chr1_35322341_35322540 0.25 SMIM12
small integral membrane protein 12
2206
0.23
chr5_53815191_53815729 0.25 SNX18
sorting nexin 18
1867
0.46
chr1_17379040_17379191 0.25 SDHB
succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
1550
0.37
chr6_47010736_47010893 0.25 GPR110
G protein-coupled receptor 110
715
0.78
chr1_54517100_54517585 0.25 TMEM59
transmembrane protein 59
1523
0.25
chr1_156032386_156032537 0.25 RAB25
RAB25, member RAS oncogene family
1510
0.21
chr21_43150775_43150926 0.25 AP001615.9

8683
0.18
chr8_87534571_87534756 0.25 CPNE3
copine III
6628
0.21
chr5_134914716_134914867 0.25 CXCL14
chemokine (C-X-C motif) ligand 14
37
0.55
chr7_50425191_50425522 0.25 IKZF1
IKAROS family zinc finger 1 (Ikaros)
58111
0.13
chr20_31238150_31238301 0.25 RP11-410N8.4

48786
0.11
chr2_120156492_120156643 0.25 TMEM37
transmembrane protein 37
30910
0.14
chr4_53517593_53517744 0.25 USP46
ubiquitin specific peptidase 46
5089
0.23
chr12_94568571_94568722 0.25 RP11-74K11.2

1534
0.43
chr20_32438083_32438241 0.25 CHMP4B
charged multivesicular body protein 4B
39052
0.13
chr1_207226034_207226222 0.25 YOD1
YOD1 deubiquitinase
197
0.75
chr5_138942637_138942977 0.25 UBE2D2
ubiquitin-conjugating enzyme E2D 2
1193
0.45
chr9_134579612_134579763 0.25 RAPGEF1
Rap guanine nucleotide exchange factor (GEF) 1
5542
0.24
chr13_99867467_99867663 0.24 ENSG00000201793
.
9603
0.19
chr7_36678667_36679209 0.24 ENSG00000221561
.
2911
0.3
chr6_73334747_73334898 0.24 KCNQ5
potassium voltage-gated channel, KQT-like subfamily, member 5
2904
0.32
chr17_47600778_47600929 0.24 NGFR
nerve growth factor receptor
26100
0.12
chr1_178102702_178103151 0.24 RASAL2
RAS protein activator like 2
39650
0.22
chr12_104613249_104613462 0.24 TXNRD1
thioredoxin reductase 1
3796
0.26
chr7_156826274_156826425 0.24 MNX1-AS1
MNX1 antisense RNA 1 (head to head)
22850
0.15
chr2_120621924_120622075 0.24 ENSG00000238368
.
52895
0.14
chr11_102140256_102140407 0.24 RP11-864G5.3

38678
0.13
chr5_8456418_8456569 0.24 ENSG00000247516
.
4545
0.37
chr9_127030175_127030580 0.24 RP11-121A14.3

5222
0.19
chr5_136899227_136899378 0.24 ENSG00000221612
.
30159
0.2
chr4_102075262_102075413 0.24 ENSG00000221265
.
176234
0.03
chr4_100869365_100869729 0.24 RP11-15B17.1

1616
0.26
chr6_43637939_43638090 0.24 MRPS18A
mitochondrial ribosomal protein S18A
17514
0.12
chr19_4404320_4404471 0.24 CHAF1A
chromatin assembly factor 1, subunit A (p150)
1681
0.17
chr15_51915534_51915836 0.24 DMXL2
Dmx-like 2
655
0.7
chr4_89580349_89580582 0.24 HERC3
HECT and RLD domain containing E3 ubiquitin protein ligase 3
1046
0.51
chr14_97991006_97991157 0.24 ENSG00000240730
.
5429
0.35
chr10_30720160_30720460 0.24 MAP3K8
mitogen-activated protein kinase kinase kinase 8
2556
0.31
chr2_187559059_187559451 0.24 FAM171B
family with sequence similarity 171, member B
557
0.55
chr16_84769322_84769473 0.24 USP10
ubiquitin specific peptidase 10
32474
0.16
chr4_38531154_38531351 0.24 RP11-617D20.1

94944
0.08
chr6_3750232_3750480 0.24 RP11-420L9.5

989
0.52
chr9_84298176_84298387 0.24 TLE1
transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
4002
0.3
chr10_71530651_71530802 0.24 COL13A1
collagen, type XIII, alpha 1
30918
0.17
chr4_41486518_41486669 0.24 LIMCH1
LIM and calponin homology domains 1
53581
0.16
chr2_159315078_159315280 0.23 PKP4
plakophilin 4
1555
0.33
chr9_80359497_80359648 0.23 GNAQ
guanine nucleotide binding protein (G protein), q polypeptide
78343
0.1
chr12_12009079_12009249 0.23 ETV6
ets variant 6
29707
0.24
chr6_35271134_35271285 0.23 DEF6
differentially expressed in FDCP 6 homolog (mouse)
5580
0.2
chr6_10079647_10079798 0.23 OFCC1
orofacial cleft 1 candidate 1
35285
0.23
chr2_42891438_42891589 0.23 ENSG00000194270
.
26412
0.19
chr5_56205875_56206117 0.23 SETD9
SET domain containing 9
64
0.89
chr2_26232303_26232586 0.23 AC013449.1
Uncharacterized protein
19037
0.15
chr11_67170134_67170292 0.23 PPP1CA
protein phosphatase 1, catalytic subunit, alpha isozyme
811
0.3
chrX_30646272_30646423 0.23 GK
glycerol kinase
25129
0.17
chr10_48355678_48355829 0.23 ZNF488
zinc finger protein 488
652
0.61
chr3_135909805_135909961 0.23 MSL2
male-specific lethal 2 homolog (Drosophila)
3513
0.32
chr9_127526848_127527031 0.23 RP11-175D17.3

5463
0.15
chr2_135001433_135001641 0.23 MGAT5
mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase
10293
0.24
chr17_37964816_37964967 0.23 IKZF3
IKAROS family zinc finger 3 (Aiolos)
30413
0.12
chr3_111848709_111848860 0.23 GCSAM
germinal center-associated, signaling and motility
3288
0.2
chr2_192623976_192624127 0.23 AC098872.3

34100
0.19
chr1_169029691_169029842 0.23 ENSG00000252987
.
6736
0.21

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of POU6F2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0034219 carbohydrate transmembrane transport(GO:0034219)
0.1 0.2 GO:0006667 sphinganine metabolic process(GO:0006667)
0.1 0.2 GO:0002430 complement receptor mediated signaling pathway(GO:0002430)
0.1 0.2 GO:0030011 maintenance of cell polarity(GO:0030011)
0.1 0.2 GO:0002693 positive regulation of cellular extravasation(GO:0002693)
0.1 0.2 GO:0019532 oxalate transport(GO:0019532)
0.1 0.2 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.1 0.2 GO:0060510 lung saccule development(GO:0060430) Type II pneumocyte differentiation(GO:0060510)
0.0 0.1 GO:0006106 fumarate metabolic process(GO:0006106)
0.0 0.1 GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030948)
0.0 0.1 GO:2000380 regulation of mesodermal cell fate specification(GO:0042661) regulation of mesoderm development(GO:2000380)
0.0 0.2 GO:0007021 tubulin complex assembly(GO:0007021)
0.0 0.2 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.0 0.2 GO:0071731 response to nitric oxide(GO:0071731)
0.0 0.5 GO:0019369 arachidonic acid metabolic process(GO:0019369)
0.0 0.2 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.0 0.1 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.0 0.1 GO:0048714 positive regulation of oligodendrocyte differentiation(GO:0048714)
0.0 0.1 GO:0060054 positive regulation of epithelial cell proliferation involved in wound healing(GO:0060054)
0.0 0.2 GO:0005981 regulation of glycogen catabolic process(GO:0005981)
0.0 0.1 GO:0051152 positive regulation of smooth muscle cell differentiation(GO:0051152)
0.0 0.2 GO:0001866 NK T cell proliferation(GO:0001866)
0.0 0.1 GO:0052169 pathogen-associated molecular pattern dependent induction by symbiont of host innate immune response(GO:0052033) positive regulation by symbiont of host innate immune response(GO:0052166) modulation by symbiont of host innate immune response(GO:0052167) pathogen-associated molecular pattern dependent modulation by symbiont of host innate immune response(GO:0052169) pathogen-associated molecular pattern dependent induction by organism of innate immune response of other organism involved in symbiotic interaction(GO:0052257) positive regulation by organism of innate immune response in other organism involved in symbiotic interaction(GO:0052305) modulation by organism of innate immune response in other organism involved in symbiotic interaction(GO:0052306) pathogen-associated molecular pattern dependent modulation by organism of innate immune response in other organism involved in symbiotic interaction(GO:0052308)
0.0 0.3 GO:0061647 histone H3-K9 methylation(GO:0051567) histone H3-K9 modification(GO:0061647)
0.0 0.1 GO:0043312 neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312)
0.0 0.0 GO:0060061 Spemann organizer formation(GO:0060061)
0.0 0.1 GO:0032713 negative regulation of interleukin-4 production(GO:0032713)
0.0 0.1 GO:0006167 AMP biosynthetic process(GO:0006167)
0.0 0.3 GO:0071108 protein K48-linked deubiquitination(GO:0071108)
0.0 0.3 GO:0007172 signal complex assembly(GO:0007172)
0.0 0.3 GO:0018216 peptidyl-arginine methylation(GO:0018216)
0.0 0.1 GO:0003308 negative regulation of Wnt signaling pathway involved in heart development(GO:0003308)
0.0 0.1 GO:0071072 negative regulation of phospholipid biosynthetic process(GO:0071072)
0.0 0.1 GO:0060206 estrous cycle phase(GO:0060206)
0.0 0.1 GO:0070561 vitamin D receptor signaling pathway(GO:0070561)
0.0 0.1 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
0.0 0.1 GO:0002513 tolerance induction to self antigen(GO:0002513)
0.0 0.0 GO:0010980 regulation of vitamin D 24-hydroxylase activity(GO:0010979) positive regulation of vitamin D 24-hydroxylase activity(GO:0010980)
0.0 0.1 GO:2000114 regulation of establishment of cell polarity(GO:2000114)
0.0 0.1 GO:0000103 sulfate assimilation(GO:0000103)
0.0 0.1 GO:0046642 negative regulation of alpha-beta T cell proliferation(GO:0046642)
0.0 0.1 GO:0046033 AMP metabolic process(GO:0046033)
0.0 0.1 GO:0046322 negative regulation of fatty acid oxidation(GO:0046322)
0.0 0.1 GO:0009786 regulation of asymmetric cell division(GO:0009786)
0.0 0.2 GO:0070189 kynurenine metabolic process(GO:0070189)
0.0 0.2 GO:0045109 intermediate filament organization(GO:0045109)
0.0 0.2 GO:0048668 collateral sprouting(GO:0048668)
0.0 0.1 GO:0015825 L-serine transport(GO:0015825)
0.0 0.1 GO:0022417 protein maturation by protein folding(GO:0022417)
0.0 0.1 GO:0060528 secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.0 0.1 GO:0010508 positive regulation of autophagy(GO:0010508)
0.0 0.1 GO:0008354 germ cell migration(GO:0008354)
0.0 0.1 GO:0060743 epithelial cell maturation involved in prostate gland development(GO:0060743)
0.0 0.1 GO:0032927 positive regulation of activin receptor signaling pathway(GO:0032927)
0.0 0.1 GO:0032790 ribosome disassembly(GO:0032790)
0.0 0.1 GO:0001821 histamine secretion(GO:0001821)
0.0 0.0 GO:0046931 pore complex assembly(GO:0046931)
0.0 0.1 GO:0006552 leucine catabolic process(GO:0006552)
0.0 0.1 GO:0032060 bleb assembly(GO:0032060)
0.0 0.0 GO:0002282 microglial cell activation involved in immune response(GO:0002282)
0.0 0.1 GO:0051775 response to redox state(GO:0051775)
0.0 0.1 GO:0042921 glucocorticoid receptor signaling pathway(GO:0042921)
0.0 0.1 GO:0060907 positive regulation of macrophage cytokine production(GO:0060907)
0.0 0.9 GO:0030049 muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)
0.0 0.1 GO:0042447 hormone catabolic process(GO:0042447)
0.0 0.1 GO:0072393 microtubule anchoring at microtubule organizing center(GO:0072393)
0.0 0.2 GO:0045749 obsolete negative regulation of S phase of mitotic cell cycle(GO:0045749)
0.0 0.2 GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0 0.1 GO:0007256 activation of JNKK activity(GO:0007256)
0.0 0.0 GO:0031935 regulation of chromatin silencing(GO:0031935) negative regulation of chromatin silencing(GO:0031936)
0.0 0.1 GO:0009235 cobalamin metabolic process(GO:0009235)
0.0 0.0 GO:0010459 negative regulation of heart rate(GO:0010459)
0.0 0.2 GO:0050858 negative regulation of antigen receptor-mediated signaling pathway(GO:0050858) negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0 0.1 GO:0060762 regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
0.0 0.1 GO:0006975 DNA damage induced protein phosphorylation(GO:0006975)
0.0 0.0 GO:0001672 regulation of chromatin assembly or disassembly(GO:0001672)
0.0 0.0 GO:0034723 DNA replication-dependent nucleosome organization(GO:0034723)
0.0 0.1 GO:0060633 negative regulation of transcription initiation from RNA polymerase II promoter(GO:0060633) negative regulation of DNA-templated transcription, initiation(GO:2000143)
0.0 0.1 GO:0034755 iron ion transmembrane transport(GO:0034755)
0.0 0.1 GO:0002085 inhibition of neuroepithelial cell differentiation(GO:0002085)
0.0 0.0 GO:0033147 negative regulation of intracellular estrogen receptor signaling pathway(GO:0033147)
0.0 0.0 GO:0002713 negative regulation of B cell mediated immunity(GO:0002713) negative regulation of immunoglobulin mediated immune response(GO:0002890)
0.0 0.1 GO:0060539 diaphragm development(GO:0060539)
0.0 0.0 GO:0007144 female meiosis I(GO:0007144)
0.0 0.1 GO:1904358 positive regulation of telomere maintenance via telomerase(GO:0032212) positive regulation of telomere maintenance via telomere lengthening(GO:1904358)
0.0 0.1 GO:0000239 pachytene(GO:0000239)
0.0 0.1 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
0.0 0.4 GO:0006471 protein ADP-ribosylation(GO:0006471)
0.0 0.0 GO:0001661 conditioned taste aversion(GO:0001661)
0.0 0.1 GO:0060292 long term synaptic depression(GO:0060292)
0.0 0.0 GO:0001831 trophectodermal cellular morphogenesis(GO:0001831)
0.0 0.1 GO:0001973 adenosine receptor signaling pathway(GO:0001973) G-protein coupled purinergic receptor signaling pathway(GO:0035588)
0.0 0.0 GO:0042747 circadian sleep/wake cycle, REM sleep(GO:0042747)
0.0 0.1 GO:0032070 regulation of deoxyribonuclease activity(GO:0032070)
0.0 0.1 GO:0019852 L-ascorbic acid metabolic process(GO:0019852)
0.0 0.1 GO:0006048 UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.0 0.1 GO:0043320 natural killer cell activation involved in immune response(GO:0002323) natural killer cell degranulation(GO:0043320)
0.0 0.1 GO:0043923 positive regulation by host of viral transcription(GO:0043923)
0.0 0.1 GO:0015781 pyrimidine nucleotide-sugar transport(GO:0015781)
0.0 0.0 GO:0060242 contact inhibition(GO:0060242)
0.0 0.1 GO:0032455 nerve growth factor processing(GO:0032455)
0.0 0.1 GO:0034453 microtubule anchoring(GO:0034453)
0.0 0.1 GO:0006654 phosphatidic acid biosynthetic process(GO:0006654)
0.0 0.1 GO:2000095 regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000095)
0.0 0.1 GO:0018342 protein prenylation(GO:0018342) prenylation(GO:0097354)
0.0 0.1 GO:1901722 regulation of cell proliferation involved in kidney development(GO:1901722)
0.0 0.0 GO:0034145 positive regulation of toll-like receptor 4 signaling pathway(GO:0034145)
0.0 0.1 GO:0019987 obsolete negative regulation of anti-apoptosis(GO:0019987)
0.0 0.1 GO:0043441 acetoacetic acid biosynthetic process(GO:0043441)
0.0 0.1 GO:0048664 neuron fate determination(GO:0048664)
0.0 0.1 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.0 0.1 GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568)
0.0 0.1 GO:0031573 intra-S DNA damage checkpoint(GO:0031573)
0.0 0.1 GO:0051788 response to misfolded protein(GO:0051788)
0.0 0.1 GO:0032781 positive regulation of ATPase activity(GO:0032781)
0.0 0.2 GO:0016577 histone demethylation(GO:0016577)
0.0 0.1 GO:0090205 positive regulation of cholesterol metabolic process(GO:0090205)
0.0 0.1 GO:0042753 positive regulation of circadian rhythm(GO:0042753)
0.0 0.1 GO:0018106 peptidyl-histidine phosphorylation(GO:0018106)
0.0 0.0 GO:0008356 asymmetric cell division(GO:0008356)
0.0 0.0 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.0 0.1 GO:0051014 actin filament severing(GO:0051014)
0.0 0.0 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.0 0.1 GO:0060123 regulation of growth hormone secretion(GO:0060123)
0.0 0.0 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
0.0 0.0 GO:0010701 positive regulation of norepinephrine secretion(GO:0010701)
0.0 0.0 GO:0016576 histone dephosphorylation(GO:0016576)
0.0 0.0 GO:0070634 transepithelial ammonium transport(GO:0070634)
0.0 0.0 GO:0030952 establishment or maintenance of cytoskeleton polarity(GO:0030952)
0.0 0.1 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.0 0.0 GO:0072194 kidney smooth muscle tissue development(GO:0072194)
0.0 0.0 GO:0045836 positive regulation of meiotic nuclear division(GO:0045836) positive regulation of meiotic cell cycle(GO:0051446)
0.0 0.1 GO:0045945 positive regulation of transcription from RNA polymerase III promoter(GO:0045945)
0.0 0.0 GO:0060684 epithelial-mesenchymal cell signaling(GO:0060684)
0.0 0.0 GO:0071921 establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
0.0 0.0 GO:0009405 pathogenesis(GO:0009405)
0.0 0.0 GO:2000330 T-helper cell lineage commitment(GO:0002295) CD4-positive, alpha-beta T cell lineage commitment(GO:0043373) memory T cell differentiation(GO:0043379) regulation of memory T cell differentiation(GO:0043380) positive regulation of memory T cell differentiation(GO:0043382) T-helper 17 type immune response(GO:0072538) T-helper 17 cell differentiation(GO:0072539) T-helper 17 cell lineage commitment(GO:0072540) regulation of T-helper 17 type immune response(GO:2000316) positive regulation of T-helper 17 type immune response(GO:2000318) regulation of T-helper 17 cell differentiation(GO:2000319) positive regulation of T-helper 17 cell differentiation(GO:2000321) regulation of T-helper 17 cell lineage commitment(GO:2000328) positive regulation of T-helper 17 cell lineage commitment(GO:2000330)
0.0 0.1 GO:0048713 regulation of oligodendrocyte differentiation(GO:0048713) negative regulation of oligodendrocyte differentiation(GO:0048715)
0.0 0.0 GO:0022614 membrane to membrane docking(GO:0022614)
0.0 0.1 GO:0034587 piRNA metabolic process(GO:0034587)
0.0 0.0 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
0.0 0.0 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.0 0.1 GO:0035162 embryonic hemopoiesis(GO:0035162)
0.0 0.0 GO:0048496 maintenance of organ identity(GO:0048496)
0.0 0.0 GO:0007412 axon target recognition(GO:0007412)
0.0 0.0 GO:0060235 lens induction in camera-type eye(GO:0060235)
0.0 0.3 GO:0030010 establishment of cell polarity(GO:0030010)
0.0 0.1 GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway(GO:0040037)
0.0 0.0 GO:0008214 protein demethylation(GO:0006482) protein dealkylation(GO:0008214)
0.0 0.0 GO:0007181 transforming growth factor beta receptor complex assembly(GO:0007181)
0.0 0.0 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.0 0.0 GO:1903332 regulation of protein folding(GO:1903332)
0.0 0.1 GO:0007258 JUN phosphorylation(GO:0007258)
0.0 0.1 GO:0048821 erythrocyte development(GO:0048821) myeloid cell development(GO:0061515)
0.0 0.1 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
0.0 0.1 GO:0043392 negative regulation of DNA binding(GO:0043392)
0.0 0.0 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.0 0.0 GO:0002363 alpha-beta T cell lineage commitment(GO:0002363) CD4-positive or CD8-positive, alpha-beta T cell lineage commitment(GO:0043369)
0.0 0.1 GO:0033523 histone H2B ubiquitination(GO:0033523)
0.0 0.1 GO:0045410 positive regulation of interleukin-6 biosynthetic process(GO:0045410)
0.0 0.1 GO:0007090 obsolete regulation of S phase of mitotic cell cycle(GO:0007090)
0.0 0.1 GO:0043984 histone H4-K16 acetylation(GO:0043984)
0.0 0.1 GO:0070207 protein homotrimerization(GO:0070207)
0.0 0.1 GO:0006491 N-glycan processing(GO:0006491)
0.0 0.1 GO:0035020 regulation of Rac protein signal transduction(GO:0035020)
0.0 0.1 GO:0006828 manganese ion transport(GO:0006828)
0.0 0.1 GO:0002052 positive regulation of neuroblast proliferation(GO:0002052)
0.0 0.0 GO:0032516 positive regulation of phosphoprotein phosphatase activity(GO:0032516)
0.0 0.1 GO:0018195 peptidyl-arginine modification(GO:0018195)
0.0 0.0 GO:0060219 camera-type eye photoreceptor cell differentiation(GO:0060219)
0.0 0.3 GO:0006099 tricarboxylic acid cycle(GO:0006099)
0.0 0.0 GO:2000403 T cell chemotaxis(GO:0010818) regulation of T cell chemotaxis(GO:0010819) positive regulation of T cell chemotaxis(GO:0010820) regulation of lymphocyte chemotaxis(GO:1901623) regulation of lymphocyte migration(GO:2000401) positive regulation of lymphocyte migration(GO:2000403) regulation of T cell migration(GO:2000404) positive regulation of T cell migration(GO:2000406)
0.0 0.1 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)
0.0 0.0 GO:0045091 regulation of single stranded viral RNA replication via double stranded DNA intermediate(GO:0045091)
0.0 0.0 GO:0045986 negative regulation of smooth muscle contraction(GO:0045986)
0.0 0.0 GO:0002523 leukocyte migration involved in inflammatory response(GO:0002523)
0.0 0.0 GO:0033622 integrin activation(GO:0033622)
0.0 0.1 GO:0015793 glycerol transport(GO:0015793)
0.0 0.0 GO:0048548 regulation of pinocytosis(GO:0048548)
0.0 0.0 GO:0035455 response to interferon-alpha(GO:0035455)
0.0 0.1 GO:0010591 regulation of lamellipodium assembly(GO:0010591) regulation of lamellipodium organization(GO:1902743)
0.0 0.0 GO:0032905 transforming growth factor beta1 production(GO:0032905) regulation of transforming growth factor beta1 production(GO:0032908) positive regulation of transforming growth factor beta1 production(GO:0032914)
0.0 0.1 GO:0006072 glycerol-3-phosphate metabolic process(GO:0006072)
0.0 0.0 GO:0003093 regulation of glomerular filtration(GO:0003093) glomerular filtration(GO:0003094) renal filtration(GO:0097205) regulation of renal system process(GO:0098801)
0.0 0.1 GO:0031268 pseudopodium organization(GO:0031268)
0.0 0.0 GO:0050774 negative regulation of dendrite morphogenesis(GO:0050774)
0.0 0.1 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.0 0.0 GO:0043653 mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.0 0.0 GO:0002331 pre-B cell allelic exclusion(GO:0002331)
0.0 0.0 GO:0006216 cytidine catabolic process(GO:0006216) cytidine deamination(GO:0009972) cytidine metabolic process(GO:0046087)
0.0 0.0 GO:0017121 phospholipid scrambling(GO:0017121)
0.0 0.0 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.0 0.0 GO:0050872 white fat cell differentiation(GO:0050872)
0.0 0.0 GO:0019934 cGMP-mediated signaling(GO:0019934)
0.0 0.0 GO:0071549 cellular response to dexamethasone stimulus(GO:0071549)
0.0 0.0 GO:0006295 nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295)
0.0 0.0 GO:0008053 mitochondrial fusion(GO:0008053)
0.0 0.0 GO:1901655 cellular response to ketone(GO:1901655)
0.0 0.1 GO:0071285 cellular response to lithium ion(GO:0071285)
0.0 0.0 GO:0010587 miRNA metabolic process(GO:0010586) miRNA catabolic process(GO:0010587)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0002178 palmitoyltransferase complex(GO:0002178) serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0 0.2 GO:0042587 glycogen granule(GO:0042587)
0.0 0.1 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0 0.1 GO:0000791 euchromatin(GO:0000791)
0.0 0.1 GO:0042405 nuclear inclusion body(GO:0042405)
0.0 0.1 GO:0000138 Golgi trans cisterna(GO:0000138)
0.0 0.1 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 0.2 GO:0005678 obsolete chromatin assembly complex(GO:0005678)
0.0 0.2 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.0 0.1 GO:0045281 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.0 0.5 GO:0005720 nuclear heterochromatin(GO:0005720)
0.0 0.1 GO:0060201 clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201)
0.0 0.2 GO:0016461 unconventional myosin complex(GO:0016461)
0.0 0.1 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 0.4 GO:0016514 SWI/SNF complex(GO:0016514)
0.0 0.1 GO:0072487 MSL complex(GO:0072487)
0.0 0.2 GO:0045239 tricarboxylic acid cycle enzyme complex(GO:0045239)
0.0 0.2 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 0.1 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.0 0.2 GO:0005845 mRNA cap binding complex(GO:0005845) RNA cap binding complex(GO:0034518)
0.0 0.1 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.0 0.1 GO:0070552 BRISC complex(GO:0070552)
0.0 0.1 GO:0042788 polysomal ribosome(GO:0042788)
0.0 0.1 GO:0031045 dense core granule(GO:0031045)
0.0 0.1 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
0.0 0.2 GO:0005844 polysome(GO:0005844)
0.0 0.1 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 0.1 GO:0001740 Barr body(GO:0001740)
0.0 0.0 GO:0042584 chromaffin granule(GO:0042583) chromaffin granule membrane(GO:0042584)
0.0 0.7 GO:0008287 protein serine/threonine phosphatase complex(GO:0008287) phosphatase complex(GO:1903293)
0.0 0.0 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.0 0.0 GO:0044298 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0 0.0 GO:0031932 TORC2 complex(GO:0031932)
0.0 0.1 GO:0042581 specific granule(GO:0042581)
0.0 0.0 GO:0030008 TRAPP complex(GO:0030008)
0.0 0.6 GO:0015030 Cajal body(GO:0015030)
0.0 0.0 GO:0070062 extracellular exosome(GO:0070062) extracellular vesicle(GO:1903561)
0.0 0.1 GO:0031082 BLOC complex(GO:0031082) BLOC-1 complex(GO:0031083)
0.0 0.0 GO:0048179 activin receptor complex(GO:0048179)
0.0 0.1 GO:0031143 pseudopodium(GO:0031143)
0.0 0.1 GO:0051233 spindle midzone(GO:0051233)
0.0 0.0 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.0 0.1 GO:0005652 nuclear lamina(GO:0005652)
0.0 0.2 GO:0030530 obsolete heterogeneous nuclear ribonucleoprotein complex(GO:0030530)
0.0 0.5 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 0.0 GO:0005827 polar microtubule(GO:0005827)
0.0 0.1 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.1 GO:0000780 condensed nuclear chromosome, centromeric region(GO:0000780)
0.0 0.1 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0 0.2 GO:0000178 exosome (RNase complex)(GO:0000178)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0004758 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.1 0.2 GO:0019834 phospholipase A2 inhibitor activity(GO:0019834)
0.1 0.2 GO:0004875 complement receptor activity(GO:0004875)
0.1 0.5 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.1 0.3 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.1 0.2 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.1 0.2 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.1 0.2 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.1 0.3 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.1 0.4 GO:0004908 interleukin-1 receptor activity(GO:0004908)
0.0 0.1 GO:0036137 kynurenine-oxoglutarate transaminase activity(GO:0016212) kynurenine aminotransferase activity(GO:0036137)
0.0 0.1 GO:0003896 DNA primase activity(GO:0003896)
0.0 0.2 GO:0004982 N-formyl peptide receptor activity(GO:0004982)
0.0 0.2 GO:0003945 N-acetyllactosamine synthase activity(GO:0003945)
0.0 0.1 GO:0008545 JUN kinase kinase activity(GO:0008545)
0.0 0.2 GO:0008266 poly(U) RNA binding(GO:0008266)
0.0 0.1 GO:0070644 vitamin D response element binding(GO:0070644)
0.0 0.1 GO:0048039 ubiquinone binding(GO:0048039)
0.0 0.1 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.0 0.1 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0 0.3 GO:0016273 arginine N-methyltransferase activity(GO:0016273) protein-arginine N-methyltransferase activity(GO:0016274)
0.0 0.1 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.0 0.1 GO:0032139 dinucleotide insertion or deletion binding(GO:0032139)
0.0 0.1 GO:0042910 xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.0 0.1 GO:0004949 cannabinoid receptor activity(GO:0004949)
0.0 0.1 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.0 0.3 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.0 0.2 GO:0070087 chromo shadow domain binding(GO:0070087)
0.0 0.2 GO:0001671 ATPase activator activity(GO:0001671)
0.0 0.2 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.1 GO:0004999 vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.0 0.3 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.1 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 0.1 GO:0003986 acetyl-CoA hydrolase activity(GO:0003986)
0.0 0.1 GO:0016421 CoA carboxylase activity(GO:0016421)
0.0 0.1 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.0 0.1 GO:0005010 insulin-like growth factor-activated receptor activity(GO:0005010)
0.0 0.1 GO:0004904 interferon receptor activity(GO:0004904)
0.0 0.1 GO:0004083 bisphosphoglycerate mutase activity(GO:0004082) bisphosphoglycerate 2-phosphatase activity(GO:0004083) phosphoglycerate mutase activity(GO:0004619)
0.0 0.1 GO:0008475 procollagen-lysine 5-dioxygenase activity(GO:0008475)
0.0 0.1 GO:0003985 acetyl-CoA C-acetyltransferase activity(GO:0003985)
0.0 0.1 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.0 0.5 GO:0019003 GDP binding(GO:0019003)
0.0 0.1 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0 0.1 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.0 0.1 GO:0070579 methylcytosine dioxygenase activity(GO:0070579)
0.0 0.3 GO:0004697 protein kinase C activity(GO:0004697)
0.0 0.1 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.0 0.1 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0 0.1 GO:0004340 glucokinase activity(GO:0004340)
0.0 0.2 GO:0051787 misfolded protein binding(GO:0051787)
0.0 0.1 GO:0043125 ErbB-3 class receptor binding(GO:0043125)
0.0 0.1 GO:0034584 piRNA binding(GO:0034584)
0.0 0.8 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 0.2 GO:0099604 calcium-release channel activity(GO:0015278) ligand-gated calcium channel activity(GO:0099604)
0.0 0.1 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.0 0.2 GO:0016493 C-C chemokine receptor activity(GO:0016493)
0.0 0.1 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0 0.1 GO:0015038 glutathione disulfide oxidoreductase activity(GO:0015038)
0.0 0.1 GO:0008318 protein prenyltransferase activity(GO:0008318)
0.0 0.1 GO:0005384 manganese ion transmembrane transporter activity(GO:0005384)
0.0 0.1 GO:0030911 TPR domain binding(GO:0030911)
0.0 0.1 GO:0051425 PTB domain binding(GO:0051425)
0.0 0.1 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.0 0.1 GO:0016842 amidine-lyase activity(GO:0016842)
0.0 0.2 GO:0004303 estradiol 17-beta-dehydrogenase activity(GO:0004303)
0.0 0.0 GO:0008107 galactoside 2-alpha-L-fucosyltransferase activity(GO:0008107) alpha-(1,2)-fucosyltransferase activity(GO:0031127)
0.0 0.0 GO:0070643 vitamin D3 25-hydroxylase activity(GO:0030343) vitamin D 25-hydroxylase activity(GO:0070643)
0.0 0.0 GO:0002060 purine nucleobase binding(GO:0002060)
0.0 0.1 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.0 0.1 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.0 GO:0047623 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0 0.1 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 0.0 GO:0030375 thyroid hormone receptor coactivator activity(GO:0030375)
0.0 0.2 GO:0004707 MAP kinase activity(GO:0004707)
0.0 0.0 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.0 0.1 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 0.1 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.0 0.0 GO:0004677 DNA-dependent protein kinase activity(GO:0004677)
0.0 0.1 GO:0043024 ribosomal small subunit binding(GO:0043024)
0.0 0.1 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
0.0 0.1 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0 0.0 GO:0046404 ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734)
0.0 0.1 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0 0.1 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.0 0.0 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.0 0.1 GO:0004957 prostaglandin E receptor activity(GO:0004957)
0.0 0.2 GO:0048365 Rac GTPase binding(GO:0048365)
0.0 0.1 GO:0019788 NEDD8 transferase activity(GO:0019788)
0.0 0.0 GO:0043515 kinetochore binding(GO:0043515)
0.0 0.1 GO:0000828 inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832)
0.0 0.1 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0 0.1 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.0 0.2 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 0.1 GO:0001595 angiotensin receptor activity(GO:0001595) angiotensin type II receptor activity(GO:0004945)
0.0 0.0 GO:0000309 nicotinamide-nucleotide adenylyltransferase activity(GO:0000309) nicotinate-nucleotide adenylyltransferase activity(GO:0004515)
0.0 0.1 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.0 0.1 GO:0070567 cytidylyltransferase activity(GO:0070567)
0.0 0.1 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 0.1 GO:0070053 thrombospondin receptor activity(GO:0070053)
0.0 0.0 GO:0000064 L-ornithine transmembrane transporter activity(GO:0000064)
0.0 0.0 GO:0000268 peroxisome targeting sequence binding(GO:0000268)
0.0 0.2 GO:0070566 adenylyltransferase activity(GO:0070566)
0.0 0.3 GO:0030295 protein kinase activator activity(GO:0030295)
0.0 0.0 GO:0047499 calcium-independent phospholipase A2 activity(GO:0047499)
0.0 0.0 GO:0042608 T cell receptor binding(GO:0042608)
0.0 0.1 GO:0031702 type 1 angiotensin receptor binding(GO:0031702)
0.0 0.3 GO:0008186 RNA-dependent ATPase activity(GO:0008186)
0.0 0.1 GO:0050998 nitric-oxide synthase binding(GO:0050998)
0.0 0.0 GO:0004370 glycerol kinase activity(GO:0004370)
0.0 0.1 GO:0016416 carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.0 0.1 GO:0015924 mannosyl-oligosaccharide mannosidase activity(GO:0015924)
0.0 0.1 GO:0004668 protein-arginine deiminase activity(GO:0004668)
0.0 0.0 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
0.0 0.0 GO:0015254 glycerol channel activity(GO:0015254)
0.0 0.1 GO:0000339 RNA cap binding(GO:0000339)
0.0 0.0 GO:0098847 single-stranded telomeric DNA binding(GO:0043047) sequence-specific single stranded DNA binding(GO:0098847)
0.0 0.0 GO:0004062 aryl sulfotransferase activity(GO:0004062)
0.0 0.0 GO:0004939 beta-adrenergic receptor activity(GO:0004939)
0.0 0.2 GO:0019894 kinesin binding(GO:0019894)
0.0 0.0 GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity(GO:0003857)
0.0 0.0 GO:0004594 pantothenate kinase activity(GO:0004594)
0.0 0.1 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.0 0.1 GO:0004703 G-protein coupled receptor kinase activity(GO:0004703)
0.0 0.1 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.0 0.1 GO:0008242 omega peptidase activity(GO:0008242)
0.0 0.0 GO:0017089 glycolipid transporter activity(GO:0017089)
0.0 0.5 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 0.1 GO:0031419 cobalamin binding(GO:0031419)
0.0 0.3 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 0.1 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0 0.1 GO:0005123 death receptor binding(GO:0005123)
0.0 0.0 GO:0032137 guanine/thymine mispair binding(GO:0032137)
0.0 0.1 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.0 0.1 GO:0005112 Notch binding(GO:0005112)
0.0 0.0 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 0.1 GO:0048019 receptor antagonist activity(GO:0048019)
0.0 0.1 GO:0016565 obsolete general transcriptional repressor activity(GO:0016565)
0.0 0.0 GO:0004477 methenyltetrahydrofolate cyclohydrolase activity(GO:0004477)
0.0 0.1 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031)
0.0 0.1 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.0 0.1 GO:0008159 obsolete positive transcription elongation factor activity(GO:0008159)
0.0 0.0 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.0 0.0 GO:0016149 translation release factor activity, codon specific(GO:0016149)
0.0 0.0 GO:0008607 phosphorylase kinase regulator activity(GO:0008607)
0.0 0.0 GO:0004465 lipoprotein lipase activity(GO:0004465)
0.0 0.1 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.1 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.0 0.0 GO:0004774 succinate-CoA ligase activity(GO:0004774)
0.0 0.0 GO:0031628 opioid receptor binding(GO:0031628)
0.0 0.2 GO:0050699 WW domain binding(GO:0050699)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.0 0.0 PID GLYPICAN 1PATHWAY Glypican 1 network
0.0 0.3 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.1 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
0.0 0.4 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.
0.0 0.0 ST IL 13 PATHWAY Interleukin 13 (IL-13) Pathway
0.0 0.6 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 0.1 PID IL5 PATHWAY IL5-mediated signaling events
0.0 0.2 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 0.1 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.1 ST GAQ PATHWAY G alpha q Pathway
0.0 0.4 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events
0.0 0.5 PID NFAT 3PATHWAY Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.0 0.1 PID PI3KCI AKT PATHWAY Class I PI3K signaling events mediated by Akt
0.0 0.3 PID IL1 PATHWAY IL1-mediated signaling events
0.0 0.1 PID FAS PATHWAY FAS (CD95) signaling pathway
0.0 0.1 PID PI3K PLC TRK PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.0 0.2 PID CERAMIDE PATHWAY Ceramide signaling pathway
0.0 0.0 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 0.1 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.0 0.1 PID IGF1 PATHWAY IGF1 pathway
0.0 0.1 SA TRKA RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.0 0.5 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.0 0.2 PID ALK1 PATHWAY ALK1 signaling events
0.0 0.1 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.0 0.3 PID ARF6 PATHWAY Arf6 signaling events
0.0 0.0 ST G ALPHA S PATHWAY G alpha s Pathway
0.0 0.2 PID THROMBIN PAR1 PATHWAY PAR1-mediated thrombin signaling events
0.0 0.4 PID MET PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.0 0.1 PID ERBB1 RECEPTOR PROXIMAL PATHWAY EGF receptor (ErbB1) signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.0 0.1 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.0 0.5 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 0.0 REACTOME TRIGLYCERIDE BIOSYNTHESIS Genes involved in Triglyceride Biosynthesis
0.0 0.1 REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES Genes involved in p75NTR recruits signalling complexes
0.0 0.7 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.1 REACTOME G PROTEIN BETA GAMMA SIGNALLING Genes involved in G-protein beta:gamma signalling
0.0 0.1 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
0.0 0.3 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 0.4 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.0 REACTOME TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS Genes involved in TGF-beta receptor signaling activates SMADs
0.0 0.3 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 0.2 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.0 0.2 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 0.2 REACTOME POL SWITCHING Genes involved in Polymerase switching
0.0 0.2 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.1 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.2 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.0 0.1 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 0.2 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.1 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
0.0 0.1 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 0.1 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0 0.3 REACTOME RORA ACTIVATES CIRCADIAN EXPRESSION Genes involved in RORA Activates Circadian Expression
0.0 0.5 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.0 0.2 REACTOME TRAF6 MEDIATED NFKB ACTIVATION Genes involved in TRAF6 mediated NF-kB activation
0.0 0.2 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.2 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 0.2 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 0.1 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0 0.1 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 0.1 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.1 REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0 0.0 REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI Genes involved in RIP-mediated NFkB activation via DAI
0.0 0.2 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.2 REACTOME TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3 SMAD4 HETEROTRIMER Genes involved in Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
0.0 0.5 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 0.2 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks