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ENCODE: H3K4me1 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for PRDM14

Z-value: 1.42

Motif logo

Transcription factors associated with PRDM14

Gene Symbol	Gene ID	Gene Info
PRDM14 Ensembl NCBI GeneCards UniProt	ENSG00000147596.3	PRDM14

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
PRDM14	chr8_70954808_70954959	28679	0.173171	-0.76	1.9e-02	Click!
PRDM14	chr8_70982297_70982501	1163	0.520103	0.55	1.3e-01	Click!
PRDM14	chr8_70954513_70954664	28974	0.172509	-0.44	2.4e-01	Click!
PRDM14	chr8_70947603_70947754	35884	0.156452	-0.40	2.9e-01	Click!
PRDM14	chr8_70983046_70983246	416	0.858233	0.37	3.3e-01	Click!

Activity of the PRDM14 motif across conditions

Conditions sorted by the z-value of the PRDM14 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr2_235335702_235336092	0.56	ARL4C	ADP-ribosylation factor-like 4C	69347	0.14
chr14_22993542_22993693	0.53	TRAJ15	T cell receptor alpha joining 15	4963	0.12
chr9_112724157_112724308	0.46	AKAP2	A kinase (PRKA) anchor protein 2	86646	0.09
chr6_158989572_158989723	0.44	TMEM181	transmembrane protein 181	32179	0.17
chr13_40760368_40760678	0.44	ENSG00000207458	.	40441	0.22
chr1_211512294_211512445	0.44	TRAF5	TNF receptor-associated factor 5	7337	0.26
chr12_12642682_12642833	0.44	DUSP16	dual specificity phosphatase 16	31302	0.19
chr5_110570725_110571085	0.44	CAMK4	calcium/calmodulin-dependent protein kinase IV	11121	0.22
chr8_107775072_107775253	0.42	ABRA	actin-binding Rho activating protein	7311	0.23
chr6_42358903_42359338	0.42	ENSG00000221252	.	21014	0.2
chr6_152492544_152492925	0.41	SYNE1	spectrin repeat containing, nuclear envelope 1	3235	0.38
chr7_8171333_8171763	0.41	AC006042.6		17893	0.2
chr7_156715297_156715479	0.40	NOM1	nucleolar protein with MIF4G domain 1	27029	0.15
chr12_133073696_133073847	0.40	FBRSL1	fibrosin-like 1	6614	0.22
chr19_10252991_10253357	0.40	EIF3G	eukaryotic translation initiation factor 3, subunit G	22596	0.07
chr2_38928633_38928927	0.40	GALM	galactose mutarotase (aldose 1-epimerase)	20343	0.15
chrX_48573323_48573494	0.39	ENSG00000206723	.	9558	0.11
chr1_19932776_19932992	0.39	MINOS1-NBL1	MINOS1-NBL1 readthrough	9323	0.14
chr1_160623064_160623254	0.39	SLAMF1	signaling lymphocytic activation molecule family member 1	6074	0.17
chr14_98658043_98658325	0.39	ENSG00000222066	.	139903	0.05
chr10_15295996_15296147	0.39	RP11-25G10.2		16580	0.24
chr11_35371355_35371506	0.38	SLC1A2	solute carrier family 1 (glial high affinity glutamate transporter), member 2	48355	0.13
chr11_60793314_60793556	0.38	CD6	CD6 molecule	17429	0.14
chr3_18685776_18686044	0.38	ENSG00000228956	.	49469	0.19
chr14_23021663_23022058	0.38	AE000662.92	Uncharacterized protein	3674	0.13
chr22_40727726_40728019	0.37	ADSL	adenylosuccinate lyase	14635	0.18
chr2_131818162_131818313	0.37	ARHGEF4	Rho guanine nucleotide exchange factor (GEF) 4	19387	0.18
chr9_35811342_35811500	0.37	ENSG00000263448	.	126	0.85
chr6_11412425_11412673	0.36	NEDD9	neural precursor cell expressed, developmentally down-regulated 9	29968	0.22
chr5_156587143_156587294	0.36	MED7	mediator complex subunit 7	1188	0.37
chr7_76614811_76615005	0.36	DTX2P1	deltex homolog 2 pseudogene 1	4489	0.17
chr3_101832900_101833053	0.36	ZPLD1	zona pellucida-like domain containing 1	14888	0.29
chr16_24024994_24025527	0.35	PRKCB	protein kinase C, beta	137746	0.05
chr7_92666839_92666990	0.35	ENSG00000266794	.	66301	0.11
chr1_93438182_93438873	0.35	ENSG00000239710	.	2153	0.19
chr2_109647371_109647603	0.35	EDAR	ectodysplasin A receptor	41659	0.19
chr11_62308851_62309123	0.35	AHNAK	AHNAK nucleoprotein	4148	0.1
chr2_218474863_218475091	0.35	DIRC3	disrupted in renal carcinoma 3	146301	0.04
chr15_66168923_66169074	0.35	RAB11A	RAB11A, member RAS oncogene family	6647	0.21
chr7_142981212_142981434	0.34	TMEM139	transmembrane protein 139	720	0.45
chr9_132345350_132345729	0.34	RP11-492E3.2		7851	0.14
chr19_34758530_34758681	0.34	KIAA0355	KIAA0355	13103	0.21
chr13_41228912_41229120	0.34	FOXO1	forkhead box O1	11718	0.24
chr20_39783370_39783795	0.34	RP1-1J6.2		16939	0.18
chr8_81987954_81988187	0.34	PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	36233	0.21
chr7_149561438_149561589	0.34	RP4-751H13.7		1932	0.29
chr19_42706331_42706855	0.34	ENSG00000265122	.	9363	0.09
chr2_61046362_61046552	0.34	ENSG00000241524	.	12606	0.2
chr6_33663677_33663879	0.33	SBP1	SBP1; Uncharacterized protein	304	0.84
chr5_49714159_49714383	0.33	EMB	embigin	10290	0.33
chr11_60809205_60809690	0.33	CD6	CD6 molecule	33441	0.12
chr17_57230986_57231137	0.33	SKA2	spindle and kinetochore associated complex subunit 2	1474	0.2
chr22_39414968_39415119	0.33	APOBEC3D	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D	2075	0.19
chr7_37403219_37403780	0.33	ELMO1	engulfment and cell motility 1	10227	0.2
chr22_21288583_21288734	0.33	CRKL	v-crk avian sarcoma virus CT10 oncogene homolog-like	16944	0.1
chr8_28886696_28886847	0.32	ENSG00000200719	.	19350	0.14
chr13_50811502_50811682	0.32	ENSG00000221198	.	125781	0.05
chr15_91081084_91081235	0.32	CRTC3	CREB regulated transcription coactivator 3	7859	0.21
chr6_143235037_143235188	0.31	HIVEP2	human immunodeficiency virus type I enhancer binding protein 2	31226	0.21
chr1_183856699_183856916	0.31	COLGALT2	collagen beta(1-O)galactosyltransferase 2	58945	0.13
chr5_169690000_169690192	0.31	LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	4204	0.26
chr10_11296078_11296229	0.31	CELF2-AS1	CELF2 antisense RNA 1	65694	0.12
chr10_73837183_73837334	0.31	SPOCK2	sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2	10828	0.23
chr1_27922144_27922456	0.31	AHDC1	AT hook, DNA binding motif, containing 1	7802	0.16
chr20_61641003_61641255	0.31	BHLHE23	basic helix-loop-helix family, member e23	2742	0.26
chr2_97301816_97301967	0.31	KANSL3	KAT8 regulatory NSL complex subunit 3	2155	0.35
chrX_48578721_48578872	0.31	ENSG00000206723	.	4170	0.13
chr1_121291095_121291246	0.31	FCGR1B	Fc fragment of IgG, high affinity Ib, receptor (CD64)	355233	0.01
chr6_16413187_16413338	0.31	ENSG00000265642	.	15492	0.28
chr1_32735600_32735751	0.30	LCK	lymphocyte-specific protein tyrosine kinase	4039	0.11
chr4_40218742_40218915	0.30	RHOH	ras homolog family member H	16864	0.21
chr4_659078_659323	0.30	PDE6B	phosphodiesterase 6B, cGMP-specific, rod, beta	501	0.63
chr3_15576850_15577124	0.30	COLQ	collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase	13729	0.15
chr2_39468750_39468901	0.29	CDKL4	cyclin-dependent kinase-like 4	12152	0.2
chr11_63326262_63326413	0.29	HRASLS2	HRAS-like suppressor 2	4518	0.17
chr1_26002805_26003316	0.29	RP1-187B23.1		17458	0.17
chr2_87824602_87824793	0.29	RP11-1399P15.1		47144	0.18
chr19_46018293_46018614	0.29	VASP	vasodilator-stimulated phosphoprotein	7704	0.11
chr12_47744275_47744639	0.29	ENSG00000199566	.	4377	0.25
chr11_43963088_43963239	0.29	C11orf96	chromosome 11 open reading frame 96	892	0.55
chr17_47836943_47837172	0.29	FAM117A	family with sequence similarity 117, member A	4436	0.18
chr11_67177814_67178291	0.29	CARNS1	carnosine synthase 1	5097	0.07
chr12_90288737_90288888	0.29	ENSG00000252823	.	140976	0.05
chr9_97374413_97374564	0.29	FBP2	fructose-1,6-bisphosphatase 2	18413	0.2
chr7_76116621_76116871	0.29	DTX2	deltex homolog 2 (Drosophila)	6919	0.14
chr2_173364442_173364593	0.29	ITGA6	integrin, alpha 6	11827	0.16
chr11_89978848_89978999	0.29	CHORDC1	cysteine and histidine-rich domain (CHORD) containing 1	22391	0.23
chr11_73722781_73723004	0.29	UCP3	uncoupling protein 3 (mitochondrial, proton carrier)	2412	0.24
chr14_91832903_91833121	0.29	ENSG00000265856	.	32955	0.17
chr3_39309984_39310135	0.28	CX3CR1	chemokine (C-X3-C motif) receptor 1	11466	0.2
chr2_225928880_225929173	0.28	DOCK10	dedicator of cytokinesis 10	21867	0.25
chr2_235055382_235055630	0.28	SPP2	secreted phosphoprotein 2, 24kDa	96075	0.08
chr12_82152680_82152831	0.28	PPFIA2	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2	283	0.96
chr3_33095798_33096165	0.28	GLB1	galactosidase, beta 1	42303	0.12
chr7_55377080_55377277	0.28	LANCL2	LanC lantibiotic synthetase component C-like 2 (bacterial)	55963	0.15
chr11_75235630_75235878	0.28	GDPD5	glycerophosphodiester phosphodiesterase domain containing 5	715	0.61
chr3_46019140_46019460	0.28	FYCO1	FYVE and coiled-coil domain containing 1	7187	0.19
chr11_73681374_73681615	0.28	RP11-167N4.2		162	0.93
chr18_13376887_13377038	0.28	LDLRAD4	low density lipoprotein receptor class A domain containing 4	5591	0.18
chr16_304069_304251	0.27	ITFG3	integrin alpha FG-GAP repeat containing 3	467	0.67
chr9_123668261_123668471	0.27	TRAF1	TNF receptor-associated factor 1	8484	0.2
chr11_44601673_44601894	0.27	CD82	CD82 molecule	7155	0.22
chr16_28504230_28504381	0.27	CLN3	ceroid-lipofuscinosis, neuronal 3	211	0.88
chr5_110572960_110573179	0.27	CAMK4	calcium/calmodulin-dependent protein kinase IV	13285	0.21
chr22_40307915_40308066	0.27	GRAP2	GRB2-related adaptor protein 2	10877	0.17
chr3_60066728_60066883	0.27	NPCDR1	nasopharyngeal carcinoma, down-regulated 1	109222	0.08
chr1_99303566_99303717	0.27	RP5-896L10.1		166191	0.04
chr19_11161829_11161980	0.27	SMARCA4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	7607	0.15
chr1_84970614_84970910	0.27	SPATA1	spermatogenesis associated 1	1212	0.37
chr4_114671365_114671516	0.27	CAMK2D	calcium/calmodulin-dependent protein kinase II delta	10784	0.31
chr6_167360842_167360993	0.27	RP11-514O12.4		8695	0.15
chr2_9559902_9560053	0.27	ITGB1BP1	integrin beta 1 binding protein 1	446	0.82
chr17_38081772_38082081	0.27	ORMDL3	ORM1-like 3 (S. cerevisiae)	1168	0.35
chr17_46450841_46450992	0.27	RP11-433M22.1		6816	0.16
chr12_40023753_40023976	0.27	C12orf40	chromosome 12 open reading frame 40	3879	0.28
chr15_26078408_26078559	0.27	ENSG00000199214	.	15353	0.17
chr2_42881300_42881451	0.26	ENSG00000194270	.	16274	0.22
chr18_60972200_60972351	0.26	RP11-28F1.2		9040	0.18
chr3_172304432_172304646	0.26	AC007919.2	HCG1787166; PRO1163; Uncharacterized protein	56944	0.11
chr6_143232314_143232582	0.26	HIVEP2	human immunodeficiency virus type I enhancer binding protein 2	33890	0.21
chr21_16885684_16885835	0.26	ENSG00000212564	.	100843	0.08
chr19_13232974_13233125	0.26	NACC1	nucleus accumbens associated 1, BEN and BTB (POZ) domain containing	3898	0.12
chrX_80463203_80463354	0.26	SH3BGRL	SH3 domain binding glutamic acid-rich protein like	5836	0.22
chr2_96928200_96928389	0.26	TMEM127	transmembrane protein 127	1961	0.24
chr7_138730829_138731153	0.26	ZC3HAV1L	zinc finger CCCH-type, antiviral 1-like	10216	0.21
chr12_107141176_107141327	0.26	RP11-482D24.3		14407	0.17
chr3_73065596_73065885	0.26	ENSG00000238959	.	11219	0.17
chr4_4861039_4861246	0.26	MSX1	msh homeobox 1	251	0.95
chr12_12595870_12596198	0.26	DUSP16	dual specificity phosphatase 16	78025	0.08
chr3_71181004_71181240	0.26	FOXP1	forkhead box P1	1134	0.67
chr8_143923115_143923266	0.26	RP11-706C16.5		6834	0.13
chr21_34920280_34920507	0.26	SON	SON DNA binding protein	4161	0.15
chr2_204583285_204583561	0.26	CD28	CD28 molecule	12007	0.23
chr4_156588004_156588172	0.25	GUCY1A3	guanylate cyclase 1, soluble, alpha 3	27	0.99
chr6_149586290_149586441	0.25	RP1-111D6.2		21228	0.17
chr11_118217576_118217727	0.25	CD3G	CD3g molecule, gamma (CD3-TCR complex)	2580	0.16
chr11_128336531_128336741	0.25	ETS1	v-ets avian erythroblastosis virus E26 oncogene homolog 1	38653	0.19
chr19_1029365_1029639	0.25	CNN2	calponin 2	1634	0.17
chr1_233060752_233060903	0.25	NTPCR	nucleoside-triphosphatase, cancer-related	25543	0.23
chr20_47837005_47837164	0.25	DDX27	DEAD (Asp-Glu-Ala-Asp) box polypeptide 27	1200	0.44
chr6_135328118_135328269	0.25	HBS1L	HBS1-like (S. cerevisiae)	19310	0.2
chr10_15009390_15009541	0.25	MEIG1	meiosis/spermiogenesis associated 1	1027	0.53
chr7_33147039_33147320	0.25	RP9	retinitis pigmentosa 9 (autosomal dominant)	1823	0.29
chr13_41186364_41186802	0.25	FOXO1	forkhead box O1	54151	0.14
chr5_40389886_40390037	0.25	ENSG00000265615	.	69541	0.13
chr5_32422457_32422656	0.25	ZFR	zinc finger RNA binding protein	22311	0.17
chr1_59221554_59222263	0.25	ENSG00000264081	.	8699	0.2
chr1_154236940_154237091	0.24	ENSG00000201129	.	4812	0.09
chr10_73523497_73523780	0.24	C10orf54	chromosome 10 open reading frame 54	6251	0.2
chr1_92345001_92345152	0.24	TGFBR3	transforming growth factor, beta receptor III	6590	0.23
chr4_40227290_40227508	0.24	RHOH	ras homolog family member H	25435	0.19
chr1_160737774_160738091	0.24	LY9	lymphocyte antigen 9	27932	0.13
chr11_122593206_122593357	0.24	ENSG00000239079	.	3738	0.3
chr2_112183128_112183279	0.24	ENSG00000266139	.	104535	0.08
chr6_445376_445527	0.24	IRF4	interferon regulatory factor 4	53712	0.15
chrX_153670356_153670666	0.24	FAM50A	family with sequence similarity 50, member A	1962	0.13
chr5_139801562_139801713	0.24	ANKHD1	ankyrin repeat and KH domain containing 1	20131	0.1
chr1_54939914_54940113	0.24	ENSG00000265404	.	30328	0.15
chr1_111175695_111176178	0.24	KCNA2	potassium voltage-gated channel, shaker-related subfamily, member 2	1840	0.34
chr4_90166300_90166451	0.24	GPRIN3	GPRIN family member 3	5970	0.31
chr14_67825816_67826016	0.23	ATP6V1D	ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D	588	0.51
chr4_99923768_99923919	0.23	ENSG00000265213	.	5305	0.17
chr5_66310036_66310433	0.23	MAST4	microtubule associated serine/threonine kinase family member 4	9751	0.24
chr5_130876979_130877130	0.23	RAPGEF6	Rap guanine nucleotide exchange factor (GEF) 6	8328	0.31
chr2_235372019_235372185	0.23	ARL4C	ADP-ribosylation factor-like 4C	33142	0.25
chr2_85547253_85547583	0.23	TGOLN2	trans-golgi network protein 2	7690	0.1
chr14_21492164_21492434	0.23	NDRG2	NDRG family member 2	44	0.94
chr8_134557129_134557280	0.23	ST3GAL1	ST3 beta-galactoside alpha-2,3-sialyltransferase 1	26888	0.25
chr12_12688522_12688673	0.23	DUSP16	dual specificity phosphatase 16	14538	0.23
chr17_62980724_62981042	0.23	AMZ2P1	archaelysin family metallopeptidase 2 pseudogene 1	11248	0.15
chr3_15397693_15398324	0.23	SH3BP5	SH3-domain binding protein 5 (BTK-associated)	15133	0.13
chr2_37779846_37779997	0.23	AC006369.2		47358	0.16
chr7_150145674_150145844	0.23	GIMAP8	GTPase, IMAP family member 8	1959	0.3
chr6_5869430_5869581	0.23	ENSG00000239472	.	49572	0.18
chr21_45438725_45438957	0.23	TRAPPC10	trafficking protein particle complex 10	6641	0.18
chr11_133798043_133798269	0.23	IGSF9B	immunoglobulin superfamily, member 9B	18031	0.18
chr8_128203606_128203757	0.23	POU5F1B	POU class 5 homeobox 1B	222854	0.02
chr5_38651137_38651288	0.23	LIFR	leukemia inhibitory factor receptor alpha	55706	0.13
chr2_169306074_169306297	0.23	ENSG00000241074	.	1649	0.37
chr10_63797028_63797397	0.23	ARID5B	AT rich interactive domain 5B (MRF1-like)	11758	0.27
chr6_3914299_3914450	0.22	FAM50B	family with sequence similarity 50, member B	64752	0.09
chr20_50112296_50112621	0.22	ENSG00000266761	.	42944	0.17
chr2_36470490_36470856	0.22	CRIM1	cysteine rich transmembrane BMP regulator 1 (chordin-like)	112396	0.07
chr13_74644927_74645078	0.22	KLF12	Kruppel-like factor 12	63392	0.15
chr8_71302425_71302576	0.22	NCOA2	nuclear receptor coactivator 2	12322	0.22
chr9_278055_278426	0.22	DOCK8	dedicator of cytokinesis 8	5170	0.21
chr10_106695608_106695759	0.22	SORCS3	sortilin-related VPS10 domain containing receptor 3	223003	0.02
chr2_69873136_69873317	0.22	AAK1	AP2 associated kinase 1	2377	0.31
chr12_92796935_92797431	0.22	RP11-693J15.4		18124	0.18
chr1_83974579_83974774	0.22	ENSG00000223231	.	284884	0.01
chr15_43425377_43425535	0.22	TMEM62	transmembrane protein 62	96	0.97
chr20_50018009_50018160	0.22	ENSG00000263645	.	24226	0.22
chr13_77902502_77902886	0.22	MYCBP2	MYC binding protein 2, E3 ubiquitin protein ligase	1515	0.56
chrX_48570231_48570454	0.22	ENSG00000206723	.	12624	0.11
chr6_143872640_143872791	0.22	RP11-436I24.1		10453	0.17
chrX_48570630_48571127	0.22	ENSG00000206723	.	12088	0.11
chr19_49497399_49497775	0.22	RUVBL2	RuvB-like AAA ATPase 2	421	0.56
chr7_142147924_142148075	0.22	PRSS3P3	protease, serine, 3 pseudogene 3	158390	0.03
chr4_122108977_122109128	0.21	ENSG00000252183	.	5006	0.25
chr14_64116714_64117321	0.21	ENSG00000200693	.	1200	0.38

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of PRDM14

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0016242	negative regulation of macroautophagy(GO:0016242)
0.1	0.2	GO:0045591	positive regulation of regulatory T cell differentiation(GO:0045591)
0.1	0.3	GO:0033152	immunoglobulin V(D)J recombination(GO:0033152)
0.1	0.2	GO:1900120	regulation of receptor binding(GO:1900120) negative regulation of receptor binding(GO:1900121)
0.1	0.2	GO:0090286	cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.1	0.1	GO:0002326	B cell lineage commitment(GO:0002326)
0.1	0.2	GO:0043162	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.1	0.2	GO:0045074	interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.0	0.1	GO:0001831	trophectodermal cellular morphogenesis(GO:0001831)
0.0	0.1	GO:0045722	positive regulation of gluconeogenesis(GO:0045722)
0.0	0.1	GO:0047484	regulation of response to osmotic stress(GO:0047484)
0.0	0.1	GO:0006701	progesterone biosynthetic process(GO:0006701)
0.0	0.2	GO:0045066	regulatory T cell differentiation(GO:0045066)
0.0	0.1	GO:0048478	replication fork protection(GO:0048478)
0.0	0.2	GO:0051797	regulation of hair follicle development(GO:0051797)
0.0	0.1	GO:0071243	cellular response to arsenic-containing substance(GO:0071243)
0.0	0.1	GO:0022038	corpus callosum development(GO:0022038)
0.0	0.2	GO:0046666	retinal cell programmed cell death(GO:0046666)
0.0	0.1	GO:0018125	peptidyl-cysteine methylation(GO:0018125)
0.0	0.1	GO:0010761	fibroblast migration(GO:0010761)
0.0	0.1	GO:0045542	positive regulation of cholesterol biosynthetic process(GO:0045542)
0.0	0.1	GO:0033962	cytoplasmic mRNA processing body assembly(GO:0033962)
0.0	0.1	GO:0046476	glycosylceramide biosynthetic process(GO:0046476)
0.0	0.1	GO:0035511	oxidative DNA demethylation(GO:0035511)
0.0	0.2	GO:0000183	chromatin silencing at rDNA(GO:0000183)
0.0	0.1	GO:0003100	regulation of systemic arterial blood pressure by endothelin(GO:0003100)
0.0	0.1	GO:0007132	meiotic metaphase I(GO:0007132)
0.0	0.2	GO:0046037	GMP metabolic process(GO:0046037)
0.0	0.1	GO:0001714	endodermal cell fate specification(GO:0001714) regulation of endodermal cell fate specification(GO:0042663) regulation of endodermal cell differentiation(GO:1903224)
0.0	0.1	GO:0034219	carbohydrate transmembrane transport(GO:0034219)
0.0	0.1	GO:0048712	negative regulation of astrocyte differentiation(GO:0048712)
0.0	0.1	GO:0055089	fatty acid homeostasis(GO:0055089)
0.0	0.1	GO:0006167	AMP biosynthetic process(GO:0006167)
0.0	0.1	GO:0050857	positive regulation of antigen receptor-mediated signaling pathway(GO:0050857)
0.0	0.1	GO:0071364	cellular response to epidermal growth factor stimulus(GO:0071364)
0.0	0.0	GO:0046007	negative regulation of activated T cell proliferation(GO:0046007)
0.0	0.1	GO:0033629	negative regulation of cell adhesion mediated by integrin(GO:0033629)
0.0	0.1	GO:0002282	microglial cell activation involved in immune response(GO:0002282)
0.0	0.1	GO:0022614	membrane to membrane docking(GO:0022614)
0.0	0.1	GO:0010923	negative regulation of phosphatase activity(GO:0010923) negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.0	0.1	GO:0032747	positive regulation of interleukin-23 production(GO:0032747)
0.0	0.0	GO:0060340	positive regulation of type I interferon-mediated signaling pathway(GO:0060340)
0.0	0.1	GO:0070779	D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0	0.0	GO:0010956	negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137)
0.0	0.1	GO:0042983	amyloid precursor protein biosynthetic process(GO:0042983) regulation of amyloid precursor protein biosynthetic process(GO:0042984)
0.0	0.1	GO:0045990	carbon catabolite regulation of transcription(GO:0045990) regulation of transcription by glucose(GO:0046015)
0.0	0.1	GO:0002072	optic cup morphogenesis involved in camera-type eye development(GO:0002072)
0.0	0.1	GO:0035025	positive regulation of Rho protein signal transduction(GO:0035025)
0.0	0.0	GO:0045112	integrin biosynthetic process(GO:0045112)
0.0	0.0	GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518) negative regulation of signal transduction by p53 class mediator(GO:1901797)
0.0	0.1	GO:0007191	adenylate cyclase-activating dopamine receptor signaling pathway(GO:0007191)
0.0	0.0	GO:0019730	antimicrobial humoral response(GO:0019730) antibacterial humoral response(GO:0019731)
0.0	0.1	GO:0060158	phospholipase C-activating dopamine receptor signaling pathway(GO:0060158)
0.0	0.0	GO:0035588	adenosine receptor signaling pathway(GO:0001973) G-protein coupled purinergic receptor signaling pathway(GO:0035588)
0.0	0.1	GO:0042483	negative regulation of odontogenesis(GO:0042483)
0.0	0.0	GO:1901419	regulation of response to alcohol(GO:1901419)
0.0	0.0	GO:0032237	activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0	0.0	GO:0019276	UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.0	0.0	GO:0061117	negative regulation of cardiac muscle tissue growth(GO:0055022) negative regulation of cardiac muscle tissue development(GO:0055026) negative regulation of cardiac muscle cell proliferation(GO:0060044) negative regulation of heart growth(GO:0061117)
0.0	0.1	GO:0070208	protein heterotrimerization(GO:0070208)
0.0	0.1	GO:0061462	protein targeting to lysosome(GO:0006622) protein targeting to vacuole(GO:0006623) protein localization to lysosome(GO:0061462) protein localization to vacuole(GO:0072665) establishment of protein localization to vacuole(GO:0072666)
0.0	0.2	GO:0043968	histone H2A acetylation(GO:0043968)
0.0	0.0	GO:0006883	cellular sodium ion homeostasis(GO:0006883)
0.0	0.0	GO:0002313	mature B cell differentiation involved in immune response(GO:0002313)
0.0	0.0	GO:0032071	regulation of endodeoxyribonuclease activity(GO:0032071)
0.0	0.1	GO:0045071	negative regulation of viral genome replication(GO:0045071)
0.0	0.1	GO:0032354	response to follicle-stimulating hormone(GO:0032354)
0.0	0.1	GO:0030581	intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) regulation by virus of viral protein levels in host cell(GO:0046719) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708)
0.0	0.2	GO:0071445	obsolete cellular response to protein stimulus(GO:0071445)
0.0	0.0	GO:0070682	proteasome regulatory particle assembly(GO:0070682)
0.0	0.1	GO:0007023	post-chaperonin tubulin folding pathway(GO:0007023)
0.0	0.0	GO:0035405	histone-threonine phosphorylation(GO:0035405)
0.0	0.1	GO:0008089	anterograde axonal transport(GO:0008089)
0.0	0.1	GO:0032494	response to peptidoglycan(GO:0032494)
0.0	0.1	GO:0032776	DNA methylation on cytosine(GO:0032776) C-5 methylation of cytosine(GO:0090116)
0.0	0.1	GO:0043922	negative regulation by host of viral transcription(GO:0043922)
0.0	0.0	GO:2000758	positive regulation of histone acetylation(GO:0035066) positive regulation of protein acetylation(GO:1901985) positive regulation of peptidyl-lysine acetylation(GO:2000758)
0.0	0.1	GO:0060605	tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662)
0.0	0.1	GO:0014721	voluntary skeletal muscle contraction(GO:0003010) twitch skeletal muscle contraction(GO:0014721)
0.0	0.1	GO:0032486	Rap protein signal transduction(GO:0032486)
0.0	0.2	GO:0007263	nitric oxide mediated signal transduction(GO:0007263)
0.0	0.0	GO:0018076	N-terminal peptidyl-lysine acetylation(GO:0018076)
0.0	0.1	GO:0045084	positive regulation of interleukin-12 biosynthetic process(GO:0045084)
0.0	0.1	GO:0002639	positive regulation of immunoglobulin production(GO:0002639)
0.0	0.1	GO:0051319	mitotic G2 phase(GO:0000085) G2 phase(GO:0051319)
0.0	0.1	GO:0030240	skeletal muscle thin filament assembly(GO:0030240)
0.0	0.0	GO:0048861	leukemia inhibitory factor signaling pathway(GO:0048861)
0.0	0.0	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II(GO:0019886)
0.0	0.1	GO:0090201	negative regulation of mitochondrion organization(GO:0010823) negative regulation of release of cytochrome c from mitochondria(GO:0090201) negative regulation of apoptotic signaling pathway(GO:2001234)
0.0	0.1	GO:0043558	regulation of translational initiation in response to stress(GO:0043558)
0.0	0.1	GO:0000076	DNA replication checkpoint(GO:0000076)
0.0	0.0	GO:0006295	nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295)
0.0	0.1	GO:0060080	inhibitory postsynaptic potential(GO:0060080)
0.0	0.1	GO:0019059	obsolete initiation of viral infection(GO:0019059)
0.0	0.1	GO:0060766	negative regulation of androgen receptor signaling pathway(GO:0060766)
0.0	0.1	GO:0007143	female meiotic division(GO:0007143)
0.0	0.1	GO:0006491	N-glycan processing(GO:0006491)
0.0	0.0	GO:0040016	embryonic cleavage(GO:0040016)
0.0	0.2	GO:0021516	dorsal spinal cord development(GO:0021516)
0.0	0.0	GO:0050955	thermoception(GO:0050955)
0.0	0.1	GO:0006000	fructose metabolic process(GO:0006000)
0.0	0.0	GO:0002677	negative regulation of chronic inflammatory response(GO:0002677)
0.0	0.1	GO:0043330	response to exogenous dsRNA(GO:0043330)
0.0	0.0	GO:0048537	mucosal-associated lymphoid tissue development(GO:0048537)
0.0	0.1	GO:0008291	acetylcholine metabolic process(GO:0008291) acetate ester metabolic process(GO:1900619)
0.0	0.0	GO:1903514	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum(GO:0010880) release of sequestered calcium ion into cytosol by sarcoplasmic reticulum(GO:0014808) calcium ion transport from endoplasmic reticulum to cytosol(GO:1903514)
0.0	0.9	GO:0050852	T cell receptor signaling pathway(GO:0050852)
0.0	0.3	GO:0030890	positive regulation of B cell proliferation(GO:0030890)
0.0	0.0	GO:0019987	obsolete negative regulation of anti-apoptosis(GO:0019987)
0.0	0.0	GO:0000101	sulfur amino acid transport(GO:0000101) L-cystine transport(GO:0015811)
0.0	0.0	GO:0032959	inositol trisphosphate biosynthetic process(GO:0032959)
0.0	0.3	GO:0000188	inactivation of MAPK activity(GO:0000188)
0.0	0.0	GO:2000188	regulation of cholesterol homeostasis(GO:2000188) positive regulation of cholesterol homeostasis(GO:2000189)
0.0	0.1	GO:0032456	endocytic recycling(GO:0032456)
0.0	0.0	GO:0010800	positive regulation of peptidyl-threonine phosphorylation(GO:0010800)
0.0	0.0	GO:0043984	histone H4-K16 acetylation(GO:0043984)
0.0	0.0	GO:0018206	peptidyl-methionine modification(GO:0018206)
0.0	0.0	GO:0031167	rRNA methylation(GO:0031167)
0.0	0.0	GO:0000281	mitotic cytokinesis(GO:0000281)
0.0	0.0	GO:1904019	endothelial cell apoptotic process(GO:0072577) epithelial cell apoptotic process(GO:1904019) regulation of epithelial cell apoptotic process(GO:1904035) regulation of endothelial cell apoptotic process(GO:2000351)
0.0	0.0	GO:0010758	regulation of macrophage chemotaxis(GO:0010758)
0.0	0.0	GO:0009296	obsolete flagellum assembly(GO:0009296)
0.0	0.1	GO:0070670	response to interleukin-4(GO:0070670)
0.0	0.0	GO:0007638	mechanosensory behavior(GO:0007638)
0.0	0.0	GO:0060059	embryonic retina morphogenesis in camera-type eye(GO:0060059)
0.0	0.0	GO:0045046	protein import into peroxisome membrane(GO:0045046)
0.0	0.1	GO:0060707	trophoblast giant cell differentiation(GO:0060707)
0.0	0.1	GO:0042989	sequestering of actin monomers(GO:0042989)
0.0	0.2	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.0	0.0	GO:0006689	ganglioside catabolic process(GO:0006689)
0.0	0.0	GO:0032682	negative regulation of chemokine production(GO:0032682)
0.0	0.0	GO:0071436	sodium ion export(GO:0071436)
0.0	0.0	GO:0034625	fatty acid elongation, monounsaturated fatty acid(GO:0034625)
0.0	0.3	GO:0030101	natural killer cell activation(GO:0030101)
0.0	0.1	GO:0042776	mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.0	0.1	GO:0007271	synaptic transmission, cholinergic(GO:0007271)
0.0	0.0	GO:0060760	positive regulation of response to cytokine stimulus(GO:0060760)
0.0	0.1	GO:0007217	tachykinin receptor signaling pathway(GO:0007217)
0.0	0.0	GO:0031125	rRNA 3'-end processing(GO:0031125)
0.0	0.0	GO:0015015	heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0	0.0	GO:0006269	DNA replication, synthesis of RNA primer(GO:0006269)
0.0	0.1	GO:0018106	peptidyl-histidine phosphorylation(GO:0018106)
0.0	0.0	GO:0006772	thiamine metabolic process(GO:0006772)
0.0	0.0	GO:0030854	positive regulation of granulocyte differentiation(GO:0030854)
0.0	0.0	GO:0060770	negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770)
0.0	0.2	GO:0016601	Rac protein signal transduction(GO:0016601)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0034993	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0	0.2	GO:0033553	rDNA heterochromatin(GO:0033553)
0.0	0.1	GO:0005827	polar microtubule(GO:0005827)
0.0	0.1	GO:0045323	interleukin-1 receptor complex(GO:0045323)
0.0	0.1	GO:0005954	calcium- and calmodulin-dependent protein kinase complex(GO:0005954)
0.0	0.1	GO:0032045	guanyl-nucleotide exchange factor complex(GO:0032045)
0.0	0.1	GO:0005784	Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.0	0.1	GO:0031211	palmitoyltransferase complex(GO:0002178) serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0	0.1	GO:0048179	activin receptor complex(GO:0048179)
0.0	0.1	GO:0034673	inhibin-betaglycan-ActRII complex(GO:0034673)
0.0	0.1	GO:0042105	alpha-beta T cell receptor complex(GO:0042105)
0.0	0.1	GO:0005850	eukaryotic translation initiation factor 2 complex(GO:0005850)
0.0	0.2	GO:0035631	CD40 receptor complex(GO:0035631)
0.0	0.2	GO:0016471	vacuolar proton-transporting V-type ATPase complex(GO:0016471)
0.0	0.1	GO:0044224	juxtaparanode region of axon(GO:0044224)
0.0	0.1	GO:0030895	apolipoprotein B mRNA editing enzyme complex(GO:0030895)
0.0	0.0	GO:0072487	MSL complex(GO:0072487)
0.0	0.0	GO:0008540	proteasome regulatory particle, base subcomplex(GO:0008540)
0.0	0.1	GO:0042589	zymogen granule membrane(GO:0042589)
0.0	0.0	GO:0005594	collagen type IX trimer(GO:0005594)
0.0	0.1	GO:0000125	PCAF complex(GO:0000125)
0.0	0.4	GO:0005776	autophagosome(GO:0005776)
0.0	0.1	GO:0043190	ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.0	0.2	GO:0035267	NuA4 histone acetyltransferase complex(GO:0035267)
0.0	0.1	GO:0008091	spectrin(GO:0008091)
0.0	0.2	GO:0005671	Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0	0.0	GO:0031235	intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0	0.1	GO:0016942	insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454)
0.0	0.1	GO:0008250	oligosaccharyltransferase complex(GO:0008250)
0.0	0.0	GO:0005588	collagen type V trimer(GO:0005588)
0.0	0.2	GO:0016514	SWI/SNF complex(GO:0016514)
0.0	0.1	GO:0032588	trans-Golgi network membrane(GO:0032588)
0.0	0.1	GO:0000940	condensed chromosome outer kinetochore(GO:0000940)
0.0	0.0	GO:0045254	pyruvate dehydrogenase complex(GO:0045254)
0.0	0.1	GO:0032590	dendrite membrane(GO:0032590)
0.0	0.0	GO:0043218	compact myelin(GO:0043218)
0.0	0.1	GO:0000276	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0	0.1	GO:0000275	mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275)
0.0	0.2	GO:0000159	protein phosphatase type 2A complex(GO:0000159)
0.0	0.1	GO:0032389	MutLalpha complex(GO:0032389)
0.0	0.2	GO:0030134	ER to Golgi transport vesicle(GO:0030134)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0031628	opioid receptor binding(GO:0031628)
0.0	0.1	GO:0015925	galactosidase activity(GO:0015925)
0.0	0.1	GO:0010485	H4 histone acetyltransferase activity(GO:0010485)
0.0	0.2	GO:0042043	neurexin family protein binding(GO:0042043)
0.0	0.1	GO:0003836	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0	0.2	GO:0005521	lamin binding(GO:0005521)
0.0	0.1	GO:0046974	histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.0	0.1	GO:0035514	DNA demethylase activity(GO:0035514) DNA-N1-methyladenine dioxygenase activity(GO:0043734)
0.0	0.1	GO:0004706	JUN kinase kinase kinase activity(GO:0004706)
0.0	0.1	GO:0033829	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.0	0.2	GO:0016493	C-C chemokine receptor activity(GO:0016493)
0.0	0.1	GO:0034236	protein kinase A catalytic subunit binding(GO:0034236)
0.0	0.2	GO:0030332	cyclin binding(GO:0030332)
0.0	0.1	GO:0032794	GTPase activating protein binding(GO:0032794)
0.0	0.1	GO:0030284	estrogen receptor activity(GO:0030284)
0.0	0.2	GO:0008889	glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.0	0.1	GO:0004803	transposase activity(GO:0004803)
0.0	0.0	GO:0005127	ciliary neurotrophic factor receptor binding(GO:0005127)
0.0	0.1	GO:0015379	potassium:chloride symporter activity(GO:0015379)
0.0	0.1	GO:0004704	NF-kappaB-inducing kinase activity(GO:0004704)
0.0	0.1	GO:0016842	amidine-lyase activity(GO:0016842)
0.0	0.3	GO:0005095	GTPase inhibitor activity(GO:0005095)
0.0	0.1	GO:0004965	G-protein coupled GABA receptor activity(GO:0004965)
0.0	0.1	GO:0047045	testosterone 17-beta-dehydrogenase (NADP+) activity(GO:0047045)
0.0	0.2	GO:0004383	guanylate cyclase activity(GO:0004383)
0.0	0.2	GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0	0.1	GO:0034452	dynactin binding(GO:0034452)
0.0	0.1	GO:0031708	bombesin receptor binding(GO:0031705) endothelin B receptor binding(GO:0031708)
0.0	0.1	GO:0030368	interleukin-17 receptor activity(GO:0030368)
0.0	0.1	GO:0003828	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0	0.1	GO:0016361	activin receptor activity, type I(GO:0016361)
0.0	0.1	GO:0008321	Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0	0.1	GO:0004983	neuropeptide Y receptor activity(GO:0004983)
0.0	0.0	GO:0008454	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0	0.1	GO:0016004	phospholipase activator activity(GO:0016004)
0.0	0.2	GO:0004950	G-protein coupled chemoattractant receptor activity(GO:0001637) chemokine receptor activity(GO:0004950)
0.0	0.0	GO:0004607	phosphatidylcholine-sterol O-acyltransferase activity(GO:0004607)
0.0	0.0	GO:0030375	thyroid hormone receptor coactivator activity(GO:0030375)
0.0	0.0	GO:0035184	histone threonine kinase activity(GO:0035184)
0.0	0.0	GO:0070492	oligosaccharide binding(GO:0070492)
0.0	0.0	GO:0030292	protein tyrosine kinase inhibitor activity(GO:0030292)
0.0	0.1	GO:0048156	tau protein binding(GO:0048156)
0.0	0.1	GO:0015271	outward rectifier potassium channel activity(GO:0015271)
0.0	0.1	GO:0003886	DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0	0.1	GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0	0.0	GO:0050693	LBD domain binding(GO:0050693)
0.0	0.1	GO:0051400	BH domain binding(GO:0051400)
0.0	0.0	GO:0008109	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0	0.2	GO:0047555	3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.0	0.1	GO:0003785	actin monomer binding(GO:0003785)
0.0	0.1	GO:0004774	succinate-CoA ligase activity(GO:0004774)
0.0	0.0	GO:0015193	L-proline transmembrane transporter activity(GO:0015193)
0.0	0.1	GO:0004331	fructose-2,6-bisphosphate 2-phosphatase activity(GO:0004331)
0.0	0.0	GO:0008545	JUN kinase kinase activity(GO:0008545)
0.0	0.2	GO:0015026	coreceptor activity(GO:0015026)
0.0	0.1	GO:0008266	poly(U) RNA binding(GO:0008266)
0.0	0.3	GO:0004683	calmodulin-dependent protein kinase activity(GO:0004683)
0.0	0.0	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0	0.0	GO:0031014	troponin T binding(GO:0031014)
0.0	0.1	GO:0008853	exodeoxyribonuclease III activity(GO:0008853)
0.0	0.0	GO:0016309	1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0	0.1	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.0	0.4	GO:0004003	ATP-dependent DNA helicase activity(GO:0004003)
0.0	0.1	GO:0004652	polynucleotide adenylyltransferase activity(GO:0004652)
0.0	0.0	GO:0050682	AF-2 domain binding(GO:0050682)
0.0	0.0	GO:0008510	sodium:bicarbonate symporter activity(GO:0008510)
0.0	0.0	GO:0051733	ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734)
0.0	0.1	GO:0016530	metallochaperone activity(GO:0016530)
0.0	0.0	GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0	0.1	GO:0034481	chondroitin sulfotransferase activity(GO:0034481)
0.0	0.1	GO:0004697	protein kinase C activity(GO:0004697)
0.0	0.1	GO:0004126	cytidine deaminase activity(GO:0004126)
0.0	0.1	GO:0016857	racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.0	0.1	GO:0019789	SUMO transferase activity(GO:0019789)
0.0	0.0	GO:0042608	T cell receptor binding(GO:0042608)
0.0	0.3	GO:0048306	calcium-dependent protein binding(GO:0048306)
0.0	0.1	GO:0015165	pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.0	0.1	GO:0048406	nerve growth factor binding(GO:0048406)
0.0	0.1	GO:0031702	type 1 angiotensin receptor binding(GO:0031702)
0.0	0.1	GO:0015643	toxic substance binding(GO:0015643)
0.0	0.0	GO:0043522	leucine zipper domain binding(GO:0043522)
0.0	0.2	GO:0043621	protein self-association(GO:0043621)
0.0	0.1	GO:0030020	extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.0	0.1	GO:0070577	lysine-acetylated histone binding(GO:0070577)
0.0	0.2	GO:0036442	hydrogen-exporting ATPase activity(GO:0036442)
0.0	0.0	GO:0000014	single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.0	0.1	GO:0035251	UDP-glucosyltransferase activity(GO:0035251)
0.0	0.0	GO:0003918	DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.0	0.1	GO:0043425	bHLH transcription factor binding(GO:0043425)
0.0	0.0	GO:0004351	glutamate decarboxylase activity(GO:0004351)
0.0	0.2	GO:0004889	acetylcholine-activated cation-selective channel activity(GO:0004889)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.1	PID RANBP2 PATHWAY	Sumoylation by RanBP2 regulates transcriptional repression
0.4	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
1.0	PID CD8 TCR PATHWAY	TCR signaling in naïve CD8+ T cells
0.2	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.2	SA CASPASE CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.3	ST WNT CA2 CYCLIC GMP PATHWAY	Wnt/Ca2+/cyclic GMP signaling.
0.4	PID TCR CALCIUM PATHWAY	Calcium signaling in the CD4+ TCR pathway
0.2	PID HIV NEF PATHWAY	HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.0	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
0.3	PID S1P META PATHWAY	Sphingosine 1-phosphate (S1P) pathway
0.2	PID WNT CANONICAL PATHWAY	Canonical Wnt signaling pathway
0.2	PID ERB GENOMIC PATHWAY	Validated nuclear estrogen receptor beta network
0.7	PID MYC REPRESS PATHWAY	Validated targets of C-MYC transcriptional repression
0.1	PID IL2 PI3K PATHWAY	IL2 signaling events mediated by PI3K
0.1	SA TRKA RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.2	PID MYC PATHWAY	C-MYC pathway
0.0	ST STAT3 PATHWAY	STAT3 Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.1	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0	REACTOME SIGNAL AMPLIFICATION	Genes involved in Signal amplification
0.1	REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR	Genes involved in Prostacyclin signalling through prostacyclin receptor
0.3	REACTOME PECAM1 INTERACTIONS	Genes involved in PECAM1 interactions
0.1	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.0	REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE	Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.5	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
0.5	REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE	Genes involved in Nitric oxide stimulates guanylate cyclase
0.2	REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL	Genes involved in NF-kB is activated and signals survival
0.1	REACTOME CD28 DEPENDENT VAV1 PATHWAY	Genes involved in CD28 dependent Vav1 pathway
0.1	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
0.1	REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS	Genes involved in Membrane binding and targetting of GAG proteins
0.3	REACTOME EFFECTS OF PIP2 HYDROLYSIS	Genes involved in Effects of PIP2 hydrolysis
0.0	REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1	Genes involved in Autodegradation of the E3 ubiquitin ligase COP1
0.1	REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION	Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0	REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1	Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.3	REACTOME RORA ACTIVATES CIRCADIAN EXPRESSION	Genes involved in RORA Activates Circadian Expression
0.0	REACTOME NRAGE SIGNALS DEATH THROUGH JNK	Genes involved in NRAGE signals death through JNK
0.5	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
0.1	REACTOME PRE NOTCH PROCESSING IN GOLGI	Genes involved in Pre-NOTCH Processing in Golgi
0.0	REACTOME PRE NOTCH EXPRESSION AND PROCESSING	Genes involved in Pre-NOTCH Expression and Processing
0.1	REACTOME G ALPHA1213 SIGNALLING EVENTS	Genes involved in G alpha (12/13) signalling events
0.1	REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING	Genes involved in Formation of ATP by chemiosmotic coupling
0.1	REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR	Genes involved in Signaling by constitutively active EGFR
0.1	REACTOME CTLA4 INHIBITORY SIGNALING	Genes involved in CTLA4 inhibitory signaling
0.0	REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES	Genes involved in p75NTR recruits signalling complexes
0.2	REACTOME SULFUR AMINO ACID METABOLISM	Genes involved in Sulfur amino acid metabolism
0.2	REACTOME ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS	Genes involved in Acetylcholine Binding And Downstream Events
0.0	REACTOME PLATELET SENSITIZATION BY LDL	Genes involved in Platelet sensitization by LDL