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ENCODE: H3K4me1 ChIP-Seq of primary human cells
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Results for PRDM14

Z-value: 1.42

Motif logo

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Transcription factors associated with PRDM14

Gene Symbol Gene ID Gene Info
PRDM14
ENSG00000147596.3 PR/SET domain 14

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr8_70954808_70954959PRDM14286790.173171-0.761.9e-02Click!
chr8_70982297_70982501PRDM1411630.5201030.551.3e-01Click!
chr8_70954513_70954664PRDM14289740.172509-0.442.4e-01Click!
chr8_70947603_70947754PRDM14358840.156452-0.402.9e-01Click!
chr8_70983046_70983246PRDM144160.8582330.373.3e-01Click!

Activity of the PRDM14 motif across conditions

Conditions sorted by the z-value of the PRDM14 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr2_235335702_235336092 0.56 ARL4C
 ADP-ribosylation factor-like 4C
 69347
 0.14
chr14_22993542_22993693 0.53 TRAJ15
 T cell receptor alpha joining 15
 4963
 0.12
chr9_112724157_112724308 0.46 AKAP2
 A kinase (PRKA) anchor protein 2
 86646
 0.09
chr6_158989572_158989723 0.44 TMEM181
 transmembrane protein 181
 32179
 0.17
chr13_40760368_40760678 0.44 ENSG00000207458
 .
 40441
 0.22
chr1_211512294_211512445 0.44 TRAF5
 TNF receptor-associated factor 5
 7337
 0.26
chr12_12642682_12642833 0.44 DUSP16
 dual specificity phosphatase 16
 31302
 0.19
chr5_110570725_110571085 0.44 CAMK4
 calcium/calmodulin-dependent protein kinase IV
 11121
 0.22
chr8_107775072_107775253 0.42 ABRA
 actin-binding Rho activating protein
 7311
 0.23
chr6_42358903_42359338 0.42 ENSG00000221252
 .
 21014
 0.2
chr6_152492544_152492925 0.41 SYNE1
 spectrin repeat containing, nuclear envelope 1
 3235
 0.38
chr7_8171333_8171763 0.41 AC006042.6
17893
 0.2
chr7_156715297_156715479 0.40 NOM1
 nucleolar protein with MIF4G domain 1
 27029
 0.15
chr12_133073696_133073847 0.40 FBRSL1
 fibrosin-like 1
 6614
 0.22
chr19_10252991_10253357 0.40 EIF3G
 eukaryotic translation initiation factor 3, subunit G
 22596
 0.07
chr2_38928633_38928927 0.40 GALM
 galactose mutarotase (aldose 1-epimerase)
 20343
 0.15
chrX_48573323_48573494 0.39 ENSG00000206723
 .
 9558
 0.11
chr1_19932776_19932992 0.39 MINOS1-NBL1
 MINOS1-NBL1 readthrough
 9323
 0.14
chr1_160623064_160623254 0.39 SLAMF1
 signaling lymphocytic activation molecule family member 1
 6074
 0.17
chr14_98658043_98658325 0.39 ENSG00000222066
 .
 139903
 0.05
chr10_15295996_15296147 0.39 RP11-25G10.2
16580
 0.24
chr11_35371355_35371506 0.38 SLC1A2
 solute carrier family 1 (glial high affinity glutamate transporter), member 2
 48355
 0.13
chr11_60793314_60793556 0.38 CD6
 CD6 molecule
 17429
 0.14
chr3_18685776_18686044 0.38 ENSG00000228956
 .
 49469
 0.19
chr14_23021663_23022058 0.38 AE000662.92
 Uncharacterized protein
 3674
 0.13
chr22_40727726_40728019 0.37 ADSL
 adenylosuccinate lyase
 14635
 0.18
chr2_131818162_131818313 0.37 ARHGEF4
 Rho guanine nucleotide exchange factor (GEF) 4
 19387
 0.18
chr9_35811342_35811500 0.37 ENSG00000263448
 .
 126
 0.85
chr6_11412425_11412673 0.36 NEDD9
 neural precursor cell expressed, developmentally down-regulated 9
 29968
 0.22
chr5_156587143_156587294 0.36 MED7
 mediator complex subunit 7
 1188
 0.37
chr7_76614811_76615005 0.36 DTX2P1
 deltex homolog 2 pseudogene 1
 4489
 0.17
chr3_101832900_101833053 0.36 ZPLD1
 zona pellucida-like domain containing 1
 14888
 0.29
chr16_24024994_24025527 0.35 PRKCB
 protein kinase C, beta
 137746
 0.05
chr7_92666839_92666990 0.35 ENSG00000266794
 .
 66301
 0.11
chr1_93438182_93438873 0.35 ENSG00000239710
 .
 2153
 0.19
chr2_109647371_109647603 0.35 EDAR
 ectodysplasin A receptor
 41659
 0.19
chr11_62308851_62309123 0.35 AHNAK
 AHNAK nucleoprotein
 4148
 0.1
chr2_218474863_218475091 0.35 DIRC3
 disrupted in renal carcinoma 3
 146301
 0.04
chr15_66168923_66169074 0.35 RAB11A
 RAB11A, member RAS oncogene family
 6647
 0.21
chr7_142981212_142981434 0.34 TMEM139
 transmembrane protein 139
 720
 0.45
chr9_132345350_132345729 0.34 RP11-492E3.2
7851
 0.14
chr19_34758530_34758681 0.34 KIAA0355
 KIAA0355
 13103
 0.21
chr13_41228912_41229120 0.34 FOXO1
 forkhead box O1
 11718
 0.24
chr20_39783370_39783795 0.34 RP1-1J6.2
16939
 0.18
chr8_81987954_81988187 0.34 PAG1
 phosphoprotein associated with glycosphingolipid microdomains 1
 36233
 0.21
chr7_149561438_149561589 0.34 RP4-751H13.7
1932
 0.29
chr19_42706331_42706855 0.34 ENSG00000265122
 .
 9363
 0.09
chr2_61046362_61046552 0.34 ENSG00000241524
 .
 12606
 0.2
chr6_33663677_33663879 0.33 SBP1
 SBP1; Uncharacterized protein
 304
 0.84
chr5_49714159_49714383 0.33 EMB
 embigin
 10290
 0.33
chr11_60809205_60809690 0.33 CD6
 CD6 molecule
 33441
 0.12
chr17_57230986_57231137 0.33 SKA2
 spindle and kinetochore associated complex subunit 2
 1474
 0.2
chr22_39414968_39415119 0.33 APOBEC3D
 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D
 2075
 0.19
chr7_37403219_37403780 0.33 ELMO1
 engulfment and cell motility 1
 10227
 0.2
chr22_21288583_21288734 0.33 CRKL
 v-crk avian sarcoma virus CT10 oncogene homolog-like
 16944
 0.1
chr8_28886696_28886847 0.32 ENSG00000200719
 .
 19350
 0.14
chr13_50811502_50811682 0.32 ENSG00000221198
 .
 125781
 0.05
chr15_91081084_91081235 0.32 CRTC3
 CREB regulated transcription coactivator 3
 7859
 0.21
chr6_143235037_143235188 0.31 HIVEP2
 human immunodeficiency virus type I enhancer binding protein 2
 31226
 0.21
chr1_183856699_183856916 0.31 COLGALT2
 collagen beta(1-O)galactosyltransferase 2
 58945
 0.13
chr5_169690000_169690192 0.31 LCP2
 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
 4204
 0.26
chr10_11296078_11296229 0.31 CELF2-AS1
 CELF2 antisense RNA 1
 65694
 0.12
chr10_73837183_73837334 0.31 SPOCK2
 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
 10828
 0.23
chr1_27922144_27922456 0.31 AHDC1
 AT hook, DNA binding motif, containing 1
 7802
 0.16
chr20_61641003_61641255 0.31 BHLHE23
 basic helix-loop-helix family, member e23
 2742
 0.26
chr2_97301816_97301967 0.31 KANSL3
 KAT8 regulatory NSL complex subunit 3
 2155
 0.35
chrX_48578721_48578872 0.31 ENSG00000206723
 .
 4170
 0.13
chr1_121291095_121291246 0.31 FCGR1B
 Fc fragment of IgG, high affinity Ib, receptor (CD64)
 355233
 0.01
chr6_16413187_16413338 0.31 ENSG00000265642
 .
 15492
 0.28
chr1_32735600_32735751 0.30 LCK
 lymphocyte-specific protein tyrosine kinase
 4039
 0.11
chr4_40218742_40218915 0.30 RHOH
 ras homolog family member H
 16864
 0.21
chr4_659078_659323 0.30 PDE6B
 phosphodiesterase 6B, cGMP-specific, rod, beta
 501
 0.63
chr3_15576850_15577124 0.30 COLQ
 collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase
 13729
 0.15
chr2_39468750_39468901 0.29 CDKL4
 cyclin-dependent kinase-like 4
 12152
 0.2
chr11_63326262_63326413 0.29 HRASLS2
 HRAS-like suppressor 2
 4518
 0.17
chr1_26002805_26003316 0.29 RP1-187B23.1
17458
 0.17
chr2_87824602_87824793 0.29 RP11-1399P15.1
47144
 0.18
chr19_46018293_46018614 0.29 VASP
 vasodilator-stimulated phosphoprotein
 7704
 0.11
chr12_47744275_47744639 0.29 ENSG00000199566
 .
 4377
 0.25
chr11_43963088_43963239 0.29 C11orf96
 chromosome 11 open reading frame 96
 892
 0.55
chr17_47836943_47837172 0.29 FAM117A
 family with sequence similarity 117, member A
 4436
 0.18
chr11_67177814_67178291 0.29 CARNS1
 carnosine synthase 1
 5097
 0.07
chr12_90288737_90288888 0.29 ENSG00000252823
 .
 140976
 0.05
chr9_97374413_97374564 0.29 FBP2
 fructose-1,6-bisphosphatase 2
 18413
 0.2
chr7_76116621_76116871 0.29 DTX2
 deltex homolog 2 (Drosophila)
 6919
 0.14
chr2_173364442_173364593 0.29 ITGA6
 integrin, alpha 6
 11827
 0.16
chr11_89978848_89978999 0.29 CHORDC1
 cysteine and histidine-rich domain (CHORD) containing 1
 22391
 0.23
chr11_73722781_73723004 0.29 UCP3
 uncoupling protein 3 (mitochondrial, proton carrier)
 2412
 0.24
chr14_91832903_91833121 0.29 ENSG00000265856
 .
 32955
 0.17
chr3_39309984_39310135 0.28 CX3CR1
 chemokine (C-X3-C motif) receptor 1
 11466
 0.2
chr2_225928880_225929173 0.28 DOCK10
 dedicator of cytokinesis 10
 21867
 0.25
chr2_235055382_235055630 0.28 SPP2
 secreted phosphoprotein 2, 24kDa
 96075
 0.08
chr12_82152680_82152831 0.28 PPFIA2
 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
 283
 0.96
chr3_33095798_33096165 0.28 GLB1
 galactosidase, beta 1
 42303
 0.12
chr7_55377080_55377277 0.28 LANCL2
 LanC lantibiotic synthetase component C-like 2 (bacterial)
 55963
 0.15
chr11_75235630_75235878 0.28 GDPD5
 glycerophosphodiester phosphodiesterase domain containing 5
 715
 0.61
chr3_46019140_46019460 0.28 FYCO1
 FYVE and coiled-coil domain containing 1
 7187
 0.19
chr11_73681374_73681615 0.28 RP11-167N4.2
162
 0.93
chr18_13376887_13377038 0.28 LDLRAD4
 low density lipoprotein receptor class A domain containing 4
 5591
 0.18
chr16_304069_304251 0.27 ITFG3
 integrin alpha FG-GAP repeat containing 3
 467
 0.67
chr9_123668261_123668471 0.27 TRAF1
 TNF receptor-associated factor 1
 8484
 0.2
chr11_44601673_44601894 0.27 CD82
 CD82 molecule
 7155
 0.22
chr16_28504230_28504381 0.27 CLN3
 ceroid-lipofuscinosis, neuronal 3
 211
 0.88
chr5_110572960_110573179 0.27 CAMK4
 calcium/calmodulin-dependent protein kinase IV
 13285
 0.21
chr22_40307915_40308066 0.27 GRAP2
 GRB2-related adaptor protein 2
 10877
 0.17
chr3_60066728_60066883 0.27 NPCDR1
 nasopharyngeal carcinoma, down-regulated 1
 109222
 0.08
chr1_99303566_99303717 0.27 RP5-896L10.1
166191
 0.04
chr19_11161829_11161980 0.27 SMARCA4
 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
 7607
 0.15
chr1_84970614_84970910 0.27 SPATA1
 spermatogenesis associated 1
 1212
 0.37
chr4_114671365_114671516 0.27 CAMK2D
 calcium/calmodulin-dependent protein kinase II delta
 10784
 0.31
chr6_167360842_167360993 0.27 RP11-514O12.4
8695
 0.15
chr2_9559902_9560053 0.27 ITGB1BP1
 integrin beta 1 binding protein 1
 446
 0.82
chr17_38081772_38082081 0.27 ORMDL3
 ORM1-like 3 (S. cerevisiae)
 1168
 0.35
chr17_46450841_46450992 0.27 RP11-433M22.1
6816
 0.16
chr12_40023753_40023976 0.27 C12orf40
 chromosome 12 open reading frame 40
 3879
 0.28
chr15_26078408_26078559 0.27 ENSG00000199214
 .
 15353
 0.17
chr2_42881300_42881451 0.26 ENSG00000194270
 .
 16274
 0.22
chr18_60972200_60972351 0.26 RP11-28F1.2
9040
 0.18
chr3_172304432_172304646 0.26 AC007919.2
 HCG1787166; PRO1163; Uncharacterized protein
 56944
 0.11
chr6_143232314_143232582 0.26 HIVEP2
 human immunodeficiency virus type I enhancer binding protein 2
 33890
 0.21
chr21_16885684_16885835 0.26 ENSG00000212564
 .
 100843
 0.08
chr19_13232974_13233125 0.26 NACC1
 nucleus accumbens associated 1, BEN and BTB (POZ) domain containing
 3898
 0.12
chrX_80463203_80463354 0.26 SH3BGRL
 SH3 domain binding glutamic acid-rich protein like
 5836
 0.22
chr2_96928200_96928389 0.26 TMEM127
 transmembrane protein 127
 1961
 0.24
chr7_138730829_138731153 0.26 ZC3HAV1L
 zinc finger CCCH-type, antiviral 1-like
 10216
 0.21
chr12_107141176_107141327 0.26 RP11-482D24.3
14407
 0.17
chr3_73065596_73065885 0.26 ENSG00000238959
 .
 11219
 0.17
chr4_4861039_4861246 0.26 MSX1
 msh homeobox 1
 251
 0.95
chr12_12595870_12596198 0.26 DUSP16
 dual specificity phosphatase 16
 78025
 0.08
chr3_71181004_71181240 0.26 FOXP1
 forkhead box P1
 1134
 0.67
chr8_143923115_143923266 0.26 RP11-706C16.5
6834
 0.13
chr21_34920280_34920507 0.26 SON
 SON DNA binding protein
 4161
 0.15
chr2_204583285_204583561 0.26 CD28
 CD28 molecule
 12007
 0.23
chr4_156588004_156588172 0.25 GUCY1A3
 guanylate cyclase 1, soluble, alpha 3
 27
 0.99
chr6_149586290_149586441 0.25 RP1-111D6.2
21228
 0.17
chr11_118217576_118217727 0.25 CD3G
 CD3g molecule, gamma (CD3-TCR complex)
 2580
 0.16
chr11_128336531_128336741 0.25 ETS1
 v-ets avian erythroblastosis virus E26 oncogene homolog 1
 38653
 0.19
chr19_1029365_1029639 0.25 CNN2
 calponin 2
 1634
 0.17
chr1_233060752_233060903 0.25 NTPCR
 nucleoside-triphosphatase, cancer-related
 25543
 0.23
chr20_47837005_47837164 0.25 DDX27
 DEAD (Asp-Glu-Ala-Asp) box polypeptide 27
 1200
 0.44
chr6_135328118_135328269 0.25 HBS1L
 HBS1-like (S. cerevisiae)
 19310
 0.2
chr10_15009390_15009541 0.25 MEIG1
 meiosis/spermiogenesis associated 1
 1027
 0.53
chr7_33147039_33147320 0.25 RP9
 retinitis pigmentosa 9 (autosomal dominant)
 1823
 0.29
chr13_41186364_41186802 0.25 FOXO1
 forkhead box O1
 54151
 0.14
chr5_40389886_40390037 0.25 ENSG00000265615
 .
 69541
 0.13
chr5_32422457_32422656 0.25 ZFR
 zinc finger RNA binding protein
 22311
 0.17
chr1_59221554_59222263 0.25 ENSG00000264081
 .
 8699
 0.2
chr1_154236940_154237091 0.24 ENSG00000201129
 .
 4812
 0.09
chr10_73523497_73523780 0.24 C10orf54
 chromosome 10 open reading frame 54
 6251
 0.2
chr1_92345001_92345152 0.24 TGFBR3
 transforming growth factor, beta receptor III
 6590
 0.23
chr4_40227290_40227508 0.24 RHOH
 ras homolog family member H
 25435
 0.19
chr1_160737774_160738091 0.24 LY9
 lymphocyte antigen 9
 27932
 0.13
chr11_122593206_122593357 0.24 ENSG00000239079
 .
 3738
 0.3
chr2_112183128_112183279 0.24 ENSG00000266139
 .
 104535
 0.08
chr6_445376_445527 0.24 IRF4
 interferon regulatory factor 4
 53712
 0.15
chrX_153670356_153670666 0.24 FAM50A
 family with sequence similarity 50, member A
 1962
 0.13
chr5_139801562_139801713 0.24 ANKHD1
 ankyrin repeat and KH domain containing 1
 20131
 0.1
chr1_54939914_54940113 0.24 ENSG00000265404
 .
 30328
 0.15
chr1_111175695_111176178 0.24 KCNA2
 potassium voltage-gated channel, shaker-related subfamily, member 2
 1840
 0.34
chr4_90166300_90166451 0.24 GPRIN3
 GPRIN family member 3
 5970
 0.31
chr14_67825816_67826016 0.23 ATP6V1D
 ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
 588
 0.51
chr4_99923768_99923919 0.23 ENSG00000265213
 .
 5305
 0.17
chr5_66310036_66310433 0.23 MAST4
 microtubule associated serine/threonine kinase family member 4
 9751
 0.24
chr5_130876979_130877130 0.23 RAPGEF6
 Rap guanine nucleotide exchange factor (GEF) 6
 8328
 0.31
chr2_235372019_235372185 0.23 ARL4C
 ADP-ribosylation factor-like 4C
 33142
 0.25
chr2_85547253_85547583 0.23 TGOLN2
 trans-golgi network protein 2
 7690
 0.1
chr14_21492164_21492434 0.23 NDRG2
 NDRG family member 2
 44
 0.94
chr8_134557129_134557280 0.23 ST3GAL1
 ST3 beta-galactoside alpha-2,3-sialyltransferase 1
 26888
 0.25
chr12_12688522_12688673 0.23 DUSP16
 dual specificity phosphatase 16
 14538
 0.23
chr17_62980724_62981042 0.23 AMZ2P1
 archaelysin family metallopeptidase 2 pseudogene 1
 11248
 0.15
chr3_15397693_15398324 0.23 SH3BP5
 SH3-domain binding protein 5 (BTK-associated)
 15133
 0.13
chr2_37779846_37779997 0.23 AC006369.2
47358
 0.16
chr7_150145674_150145844 0.23 GIMAP8
 GTPase, IMAP family member 8
 1959
 0.3
chr6_5869430_5869581 0.23 ENSG00000239472
 .
 49572
 0.18
chr21_45438725_45438957 0.23 TRAPPC10
 trafficking protein particle complex 10
 6641
 0.18
chr11_133798043_133798269 0.23 IGSF9B
 immunoglobulin superfamily, member 9B
 18031
 0.18
chr8_128203606_128203757 0.23 POU5F1B
 POU class 5 homeobox 1B
 222854
 0.02
chr5_38651137_38651288 0.23 LIFR
 leukemia inhibitory factor receptor alpha
 55706
 0.13
chr2_169306074_169306297 0.23 ENSG00000241074
 .
 1649
 0.37
chr10_63797028_63797397 0.23 ARID5B
 AT rich interactive domain 5B (MRF1-like)
 11758
 0.27
chr6_3914299_3914450 0.22 FAM50B
 family with sequence similarity 50, member B
 64752
 0.09
chr20_50112296_50112621 0.22 ENSG00000266761
 .
 42944
 0.17
chr2_36470490_36470856 0.22 CRIM1
 cysteine rich transmembrane BMP regulator 1 (chordin-like)
 112396
 0.07
chr13_74644927_74645078 0.22 KLF12
 Kruppel-like factor 12
 63392
 0.15
chr8_71302425_71302576 0.22 NCOA2
 nuclear receptor coactivator 2
 12322
 0.22
chr9_278055_278426 0.22 DOCK8
 dedicator of cytokinesis 8
 5170
 0.21
chr10_106695608_106695759 0.22 SORCS3
 sortilin-related VPS10 domain containing receptor 3
 223003
 0.02
chr2_69873136_69873317 0.22 AAK1
 AP2 associated kinase 1
 2377
 0.31
chr12_92796935_92797431 0.22 RP11-693J15.4
18124
 0.18
chr1_83974579_83974774 0.22 ENSG00000223231
 .
 284884
 0.01
chr15_43425377_43425535 0.22 TMEM62
 transmembrane protein 62
 96
 0.97
chr20_50018009_50018160 0.22 ENSG00000263645
 .
 24226
 0.22
chr13_77902502_77902886 0.22 MYCBP2
 MYC binding protein 2, E3 ubiquitin protein ligase
 1515
 0.56
chrX_48570231_48570454 0.22 ENSG00000206723
 .
 12624
 0.11
chr6_143872640_143872791 0.22 RP11-436I24.1
10453
 0.17
chrX_48570630_48571127 0.22 ENSG00000206723
 .
 12088
 0.11
chr19_49497399_49497775 0.22 RUVBL2
 RuvB-like AAA ATPase 2
 421
 0.56
chr7_142147924_142148075 0.22 PRSS3P3
 protease, serine, 3 pseudogene 3
 158390
 0.03
chr4_122108977_122109128 0.21 ENSG00000252183
 .
 5006
 0.25
chr14_64116714_64117321 0.21 ENSG00000200693
 .
 1200
 0.38

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of PRDM14

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0016242 negative regulation of macroautophagy(GO:0016242)
0.1 0.2 GO:0045591 positive regulation of regulatory T cell differentiation(GO:0045591)
0.1 0.3 GO:0033152 immunoglobulin V(D)J recombination(GO:0033152)
0.1 0.2 GO:1900120 regulation of receptor binding(GO:1900120) negative regulation of receptor binding(GO:1900121)
0.1 0.2 GO:0090286 cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.1 0.1 GO:0002326 B cell lineage commitment(GO:0002326)
0.1 0.2 GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.1 0.2 GO:0045074 interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.0 0.1 GO:0001831 trophectodermal cellular morphogenesis(GO:0001831)
0.0 0.1 GO:0045722 positive regulation of gluconeogenesis(GO:0045722)
0.0 0.1 GO:0047484 regulation of response to osmotic stress(GO:0047484)
0.0 0.1 GO:0006701 progesterone biosynthetic process(GO:0006701)
0.0 0.2 GO:0045066 regulatory T cell differentiation(GO:0045066)
0.0 0.1 GO:0048478 replication fork protection(GO:0048478)
0.0 0.2 GO:0051797 regulation of hair follicle development(GO:0051797)
0.0 0.1 GO:0071243 cellular response to arsenic-containing substance(GO:0071243)
0.0 0.1 GO:0022038 corpus callosum development(GO:0022038)
0.0 0.2 GO:0046666 retinal cell programmed cell death(GO:0046666)
0.0 0.1 GO:0018125 peptidyl-cysteine methylation(GO:0018125)
0.0 0.1 GO:0010761 fibroblast migration(GO:0010761)
0.0 0.1 GO:0045542 positive regulation of cholesterol biosynthetic process(GO:0045542)
0.0 0.1 GO:0033962 cytoplasmic mRNA processing body assembly(GO:0033962)
0.0 0.1 GO:0046476 glycosylceramide biosynthetic process(GO:0046476)
0.0 0.1 GO:0035511 oxidative DNA demethylation(GO:0035511)
0.0 0.2 GO:0000183 chromatin silencing at rDNA(GO:0000183)
0.0 0.1 GO:0003100 regulation of systemic arterial blood pressure by endothelin(GO:0003100)
0.0 0.1 GO:0007132 meiotic metaphase I(GO:0007132)
0.0 0.2 GO:0046037 GMP metabolic process(GO:0046037)
0.0 0.1 GO:0001714 endodermal cell fate specification(GO:0001714) regulation of endodermal cell fate specification(GO:0042663) regulation of endodermal cell differentiation(GO:1903224)
0.0 0.1 GO:0034219 carbohydrate transmembrane transport(GO:0034219)
0.0 0.1 GO:0048712 negative regulation of astrocyte differentiation(GO:0048712)
0.0 0.1 GO:0055089 fatty acid homeostasis(GO:0055089)
0.0 0.1 GO:0006167 AMP biosynthetic process(GO:0006167)
0.0 0.1 GO:0050857 positive regulation of antigen receptor-mediated signaling pathway(GO:0050857)
0.0 0.1 GO:0071364 cellular response to epidermal growth factor stimulus(GO:0071364)
0.0 0.0 GO:0046007 negative regulation of activated T cell proliferation(GO:0046007)
0.0 0.1 GO:0033629 negative regulation of cell adhesion mediated by integrin(GO:0033629)
0.0 0.1 GO:0002282 microglial cell activation involved in immune response(GO:0002282)
0.0 0.1 GO:0022614 membrane to membrane docking(GO:0022614)
0.0 0.1 GO:0010923 negative regulation of phosphatase activity(GO:0010923) negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.0 0.1 GO:0032747 positive regulation of interleukin-23 production(GO:0032747)
0.0 0.0 GO:0060340 positive regulation of type I interferon-mediated signaling pathway(GO:0060340)
0.0 0.1 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0 0.0 GO:0010956 negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137)
0.0 0.1 GO:0042983 amyloid precursor protein biosynthetic process(GO:0042983) regulation of amyloid precursor protein biosynthetic process(GO:0042984)
0.0 0.1 GO:0045990 carbon catabolite regulation of transcription(GO:0045990) regulation of transcription by glucose(GO:0046015)
0.0 0.1 GO:0002072 optic cup morphogenesis involved in camera-type eye development(GO:0002072)
0.0 0.1 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.0 0.0 GO:0045112 integrin biosynthetic process(GO:0045112)
0.0 0.0 GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518) negative regulation of signal transduction by p53 class mediator(GO:1901797)
0.0 0.1 GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway(GO:0007191)
0.0 0.0 GO:0019730 antimicrobial humoral response(GO:0019730) antibacterial humoral response(GO:0019731)
0.0 0.1 GO:0060158 phospholipase C-activating dopamine receptor signaling pathway(GO:0060158)
0.0 0.0 GO:0035588 adenosine receptor signaling pathway(GO:0001973) G-protein coupled purinergic receptor signaling pathway(GO:0035588)
0.0 0.1 GO:0042483 negative regulation of odontogenesis(GO:0042483)
0.0 0.0 GO:1901419 regulation of response to alcohol(GO:1901419)
0.0 0.0 GO:0032237 activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0 0.0 GO:0019276 UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.0 0.0 GO:0061117 negative regulation of cardiac muscle tissue growth(GO:0055022) negative regulation of cardiac muscle tissue development(GO:0055026) negative regulation of cardiac muscle cell proliferation(GO:0060044) negative regulation of heart growth(GO:0061117)
0.0 0.1 GO:0070208 protein heterotrimerization(GO:0070208)
0.0 0.1 GO:0061462 protein targeting to lysosome(GO:0006622) protein targeting to vacuole(GO:0006623) protein localization to lysosome(GO:0061462) protein localization to vacuole(GO:0072665) establishment of protein localization to vacuole(GO:0072666)
0.0 0.2 GO:0043968 histone H2A acetylation(GO:0043968)
0.0 0.0 GO:0006883 cellular sodium ion homeostasis(GO:0006883)
0.0 0.0 GO:0002313 mature B cell differentiation involved in immune response(GO:0002313)
0.0 0.0 GO:0032071 regulation of endodeoxyribonuclease activity(GO:0032071)
0.0 0.1 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.0 0.1 GO:0032354 response to follicle-stimulating hormone(GO:0032354)
0.0 0.1 GO:0030581 intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) regulation by virus of viral protein levels in host cell(GO:0046719) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708)
0.0 0.2 GO:0071445 obsolete cellular response to protein stimulus(GO:0071445)
0.0 0.0 GO:0070682 proteasome regulatory particle assembly(GO:0070682)
0.0 0.1 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
0.0 0.0 GO:0035405 histone-threonine phosphorylation(GO:0035405)
0.0 0.1 GO:0008089 anterograde axonal transport(GO:0008089)
0.0 0.1 GO:0032494 response to peptidoglycan(GO:0032494)
0.0 0.1 GO:0032776 DNA methylation on cytosine(GO:0032776) C-5 methylation of cytosine(GO:0090116)
0.0 0.1 GO:0043922 negative regulation by host of viral transcription(GO:0043922)
0.0 0.0 GO:2000758 positive regulation of histone acetylation(GO:0035066) positive regulation of protein acetylation(GO:1901985) positive regulation of peptidyl-lysine acetylation(GO:2000758)
0.0 0.1 GO:0060605 tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662)
0.0 0.1 GO:0014721 voluntary skeletal muscle contraction(GO:0003010) twitch skeletal muscle contraction(GO:0014721)
0.0 0.1 GO:0032486 Rap protein signal transduction(GO:0032486)
0.0 0.2 GO:0007263 nitric oxide mediated signal transduction(GO:0007263)
0.0 0.0 GO:0018076 N-terminal peptidyl-lysine acetylation(GO:0018076)
0.0 0.1 GO:0045084 positive regulation of interleukin-12 biosynthetic process(GO:0045084)
0.0 0.1 GO:0002639 positive regulation of immunoglobulin production(GO:0002639)
0.0 0.1 GO:0051319 mitotic G2 phase(GO:0000085) G2 phase(GO:0051319)
0.0 0.1 GO:0030240 skeletal muscle thin filament assembly(GO:0030240)
0.0 0.0 GO:0048861 leukemia inhibitory factor signaling pathway(GO:0048861)
0.0 0.0 GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II(GO:0019886)
0.0 0.1 GO:0090201 negative regulation of mitochondrion organization(GO:0010823) negative regulation of release of cytochrome c from mitochondria(GO:0090201) negative regulation of apoptotic signaling pathway(GO:2001234)
0.0 0.1 GO:0043558 regulation of translational initiation in response to stress(GO:0043558)
0.0 0.1 GO:0000076 DNA replication checkpoint(GO:0000076)
0.0 0.0 GO:0006295 nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295)
0.0 0.1 GO:0060080 inhibitory postsynaptic potential(GO:0060080)
0.0 0.1 GO:0019059 obsolete initiation of viral infection(GO:0019059)
0.0 0.1 GO:0060766 negative regulation of androgen receptor signaling pathway(GO:0060766)
0.0 0.1 GO:0007143 female meiotic division(GO:0007143)
0.0 0.1 GO:0006491 N-glycan processing(GO:0006491)
0.0 0.0 GO:0040016 embryonic cleavage(GO:0040016)
0.0 0.2 GO:0021516 dorsal spinal cord development(GO:0021516)
0.0 0.0 GO:0050955 thermoception(GO:0050955)
0.0 0.1 GO:0006000 fructose metabolic process(GO:0006000)
0.0 0.0 GO:0002677 negative regulation of chronic inflammatory response(GO:0002677)
0.0 0.1 GO:0043330 response to exogenous dsRNA(GO:0043330)
0.0 0.0 GO:0048537 mucosal-associated lymphoid tissue development(GO:0048537)
0.0 0.1 GO:0008291 acetylcholine metabolic process(GO:0008291) acetate ester metabolic process(GO:1900619)
0.0 0.0 GO:1903514 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum(GO:0010880) release of sequestered calcium ion into cytosol by sarcoplasmic reticulum(GO:0014808) calcium ion transport from endoplasmic reticulum to cytosol(GO:1903514)
0.0 0.9 GO:0050852 T cell receptor signaling pathway(GO:0050852)
0.0 0.3 GO:0030890 positive regulation of B cell proliferation(GO:0030890)
0.0 0.0 GO:0019987 obsolete negative regulation of anti-apoptosis(GO:0019987)
0.0 0.0 GO:0000101 sulfur amino acid transport(GO:0000101) L-cystine transport(GO:0015811)
0.0 0.0 GO:0032959 inositol trisphosphate biosynthetic process(GO:0032959)
0.0 0.3 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.0 0.0 GO:2000188 regulation of cholesterol homeostasis(GO:2000188) positive regulation of cholesterol homeostasis(GO:2000189)
0.0 0.1 GO:0032456 endocytic recycling(GO:0032456)
0.0 0.0 GO:0010800 positive regulation of peptidyl-threonine phosphorylation(GO:0010800)
0.0 0.0 GO:0043984 histone H4-K16 acetylation(GO:0043984)
0.0 0.0 GO:0018206 peptidyl-methionine modification(GO:0018206)
0.0 0.0 GO:0031167 rRNA methylation(GO:0031167)
0.0 0.0 GO:0000281 mitotic cytokinesis(GO:0000281)
0.0 0.0 GO:1904019 endothelial cell apoptotic process(GO:0072577) epithelial cell apoptotic process(GO:1904019) regulation of epithelial cell apoptotic process(GO:1904035) regulation of endothelial cell apoptotic process(GO:2000351)
0.0 0.0 GO:0010758 regulation of macrophage chemotaxis(GO:0010758)
0.0 0.0 GO:0009296 obsolete flagellum assembly(GO:0009296)
0.0 0.1 GO:0070670 response to interleukin-4(GO:0070670)
0.0 0.0 GO:0007638 mechanosensory behavior(GO:0007638)
0.0 0.0 GO:0060059 embryonic retina morphogenesis in camera-type eye(GO:0060059)
0.0 0.0 GO:0045046 protein import into peroxisome membrane(GO:0045046)
0.0 0.1 GO:0060707 trophoblast giant cell differentiation(GO:0060707)
0.0 0.1 GO:0042989 sequestering of actin monomers(GO:0042989)
0.0 0.2 GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.0 0.0 GO:0006689 ganglioside catabolic process(GO:0006689)
0.0 0.0 GO:0032682 negative regulation of chemokine production(GO:0032682)
0.0 0.0 GO:0071436 sodium ion export(GO:0071436)
0.0 0.0 GO:0034625 fatty acid elongation, monounsaturated fatty acid(GO:0034625)
0.0 0.3 GO:0030101 natural killer cell activation(GO:0030101)
0.0 0.1 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.0 0.1 GO:0007271 synaptic transmission, cholinergic(GO:0007271)
0.0 0.0 GO:0060760 positive regulation of response to cytokine stimulus(GO:0060760)
0.0 0.1 GO:0007217 tachykinin receptor signaling pathway(GO:0007217)
0.0 0.0 GO:0031125 rRNA 3'-end processing(GO:0031125)
0.0 0.0 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0 0.0 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
0.0 0.1 GO:0018106 peptidyl-histidine phosphorylation(GO:0018106)
0.0 0.0 GO:0006772 thiamine metabolic process(GO:0006772)
0.0 0.0 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.0 0.0 GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770)
0.0 0.2 GO:0016601 Rac protein signal transduction(GO:0016601)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 0.2 GO:0033553 rDNA heterochromatin(GO:0033553)
0.0 0.1 GO:0005827 polar microtubule(GO:0005827)
0.0 0.1 GO:0045323 interleukin-1 receptor complex(GO:0045323)
0.0 0.1 GO:0005954 calcium- and calmodulin-dependent protein kinase complex(GO:0005954)
0.0 0.1 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.1 GO:0005784 Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.0 0.1 GO:0031211 palmitoyltransferase complex(GO:0002178) serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0 0.1 GO:0048179 activin receptor complex(GO:0048179)
0.0 0.1 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673)
0.0 0.1 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.0 0.1 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.0 0.2 GO:0035631 CD40 receptor complex(GO:0035631)
0.0 0.2 GO:0016471 vacuolar proton-transporting V-type ATPase complex(GO:0016471)
0.0 0.1 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 0.1 GO:0030895 apolipoprotein B mRNA editing enzyme complex(GO:0030895)
0.0 0.0 GO:0072487 MSL complex(GO:0072487)
0.0 0.0 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.0 0.1 GO:0042589 zymogen granule membrane(GO:0042589)
0.0 0.0 GO:0005594 collagen type IX trimer(GO:0005594)
0.0 0.1 GO:0000125 PCAF complex(GO:0000125)
0.0 0.4 GO:0005776 autophagosome(GO:0005776)
0.0 0.1 GO:0043190 ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.0 0.2 GO:0035267 NuA4 histone acetyltransferase complex(GO:0035267)
0.0 0.1 GO:0008091 spectrin(GO:0008091)
0.0 0.2 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0 0.0 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 0.1 GO:0016942 insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454)
0.0 0.1 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.0 GO:0005588 collagen type V trimer(GO:0005588)
0.0 0.2 GO:0016514 SWI/SNF complex(GO:0016514)
0.0 0.1 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 0.1 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 0.0 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.0 0.1 GO:0032590 dendrite membrane(GO:0032590)
0.0 0.0 GO:0043218 compact myelin(GO:0043218)
0.0 0.1 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.1 GO:0000275 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275)
0.0 0.2 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.1 GO:0032389 MutLalpha complex(GO:0032389)
0.0 0.2 GO:0030134 ER to Golgi transport vesicle(GO:0030134)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0031628 opioid receptor binding(GO:0031628)
0.0 0.1 GO:0015925 galactosidase activity(GO:0015925)
0.0 0.1 GO:0010485 H4 histone acetyltransferase activity(GO:0010485)
0.0 0.2 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.1 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0 0.2 GO:0005521 lamin binding(GO:0005521)
0.0 0.1 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.0 0.1 GO:0035514 DNA demethylase activity(GO:0035514) DNA-N1-methyladenine dioxygenase activity(GO:0043734)
0.0 0.1 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.0 0.1 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.0 0.2 GO:0016493 C-C chemokine receptor activity(GO:0016493)
0.0 0.1 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
0.0 0.2 GO:0030332 cyclin binding(GO:0030332)
0.0 0.1 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 0.1 GO:0030284 estrogen receptor activity(GO:0030284)
0.0 0.2 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.0 0.1 GO:0004803 transposase activity(GO:0004803)
0.0 0.0 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.0 0.1 GO:0015379 potassium:chloride symporter activity(GO:0015379)
0.0 0.1 GO:0004704 NF-kappaB-inducing kinase activity(GO:0004704)
0.0 0.1 GO:0016842 amidine-lyase activity(GO:0016842)
0.0 0.3 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.0 0.1 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.0 0.1 GO:0047045 testosterone 17-beta-dehydrogenase (NADP+) activity(GO:0047045)
0.0 0.2 GO:0004383 guanylate cyclase activity(GO:0004383)
0.0 0.2 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.1 GO:0034452 dynactin binding(GO:0034452)
0.0 0.1 GO:0031708 bombesin receptor binding(GO:0031705) endothelin B receptor binding(GO:0031708)
0.0 0.1 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.0 0.1 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0 0.1 GO:0016361 activin receptor activity, type I(GO:0016361)
0.0 0.1 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0 0.1 GO:0004983 neuropeptide Y receptor activity(GO:0004983)
0.0 0.0 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0 0.1 GO:0016004 phospholipase activator activity(GO:0016004)
0.0 0.2 GO:0004950 G-protein coupled chemoattractant receptor activity(GO:0001637) chemokine receptor activity(GO:0004950)
0.0 0.0 GO:0004607 phosphatidylcholine-sterol O-acyltransferase activity(GO:0004607)
0.0 0.0 GO:0030375 thyroid hormone receptor coactivator activity(GO:0030375)
0.0 0.0 GO:0035184 histone threonine kinase activity(GO:0035184)
0.0 0.0 GO:0070492 oligosaccharide binding(GO:0070492)
0.0 0.0 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.0 0.1 GO:0048156 tau protein binding(GO:0048156)
0.0 0.1 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.0 0.1 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0 0.1 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 0.0 GO:0050693 LBD domain binding(GO:0050693)
0.0 0.1 GO:0051400 BH domain binding(GO:0051400)
0.0 0.0 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0 0.2 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.0 0.1 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.1 GO:0004774 succinate-CoA ligase activity(GO:0004774)
0.0 0.0 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
0.0 0.1 GO:0004331 fructose-2,6-bisphosphate 2-phosphatase activity(GO:0004331)
0.0 0.0 GO:0008545 JUN kinase kinase activity(GO:0008545)
0.0 0.2 GO:0015026 coreceptor activity(GO:0015026)
0.0 0.1 GO:0008266 poly(U) RNA binding(GO:0008266)
0.0 0.3 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 0.0 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 0.0 GO:0031014 troponin T binding(GO:0031014)
0.0 0.1 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
0.0 0.0 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0 0.1 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.0 0.4 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.0 0.1 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.0 0.0 GO:0050682 AF-2 domain binding(GO:0050682)
0.0 0.0 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.0 GO:0051733 ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734)
0.0 0.1 GO:0016530 metallochaperone activity(GO:0016530)
0.0 0.0 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 0.1 GO:0034481 chondroitin sulfotransferase activity(GO:0034481)
0.0 0.1 GO:0004697 protein kinase C activity(GO:0004697)
0.0 0.1 GO:0004126 cytidine deaminase activity(GO:0004126)
0.0 0.1 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.0 0.1 GO:0019789 SUMO transferase activity(GO:0019789)
0.0 0.0 GO:0042608 T cell receptor binding(GO:0042608)
0.0 0.3 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 0.1 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.0 0.1 GO:0048406 nerve growth factor binding(GO:0048406)
0.0 0.1 GO:0031702 type 1 angiotensin receptor binding(GO:0031702)
0.0 0.1 GO:0015643 toxic substance binding(GO:0015643)
0.0 0.0 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.2 GO:0043621 protein self-association(GO:0043621)
0.0 0.1 GO:0030020 extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.0 0.1 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 0.2 GO:0036442 hydrogen-exporting ATPase activity(GO:0036442)
0.0 0.0 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.0 0.1 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.0 0.0 GO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.0 0.1 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.0 0.0 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.0 0.2 GO:0004889 acetylcholine-activated cation-selective channel activity(GO:0004889)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 0.4 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 1.0 PID CD8 TCR PATHWAY TCR signaling in naïve CD8+ T cells
0.0 0.2 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 0.2 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 0.3 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 0.4 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.2 PID HIV NEF PATHWAY HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.0 0.0 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 0.3 PID S1P META PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.0 0.2 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway
0.0 0.2 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.0 0.7 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 0.1 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.0 0.1 SA TRKA RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.0 0.2 PID MYC PATHWAY C-MYC pathway
0.0 0.0 ST STAT3 PATHWAY STAT3 Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0 0.0 REACTOME SIGNAL AMPLIFICATION Genes involved in Signal amplification
0.0 0.1 REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR Genes involved in Prostacyclin signalling through prostacyclin receptor
0.0 0.3 REACTOME PECAM1 INTERACTIONS Genes involved in PECAM1 interactions
0.0 0.1 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
0.0 0.0 REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0 0.5 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.0 0.5 REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.0 0.2 REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL Genes involved in NF-kB is activated and signals survival
0.0 0.1 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 0.1 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.0 0.1 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.0 0.3 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 0.0 REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 Genes involved in Autodegradation of the E3 ubiquitin ligase COP1
0.0 0.1 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0 0.0 REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.0 0.3 REACTOME RORA ACTIVATES CIRCADIAN EXPRESSION Genes involved in RORA Activates Circadian Expression
0.0 0.0 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 0.5 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.0 0.1 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.0 REACTOME PRE NOTCH EXPRESSION AND PROCESSING Genes involved in Pre-NOTCH Expression and Processing
0.0 0.1 REACTOME G ALPHA1213 SIGNALLING EVENTS Genes involved in G alpha (12/13) signalling events
0.0 0.1 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 0.1 REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR Genes involved in Signaling by constitutively active EGFR
0.0 0.1 REACTOME CTLA4 INHIBITORY SIGNALING Genes involved in CTLA4 inhibitory signaling
0.0 0.0 REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES Genes involved in p75NTR recruits signalling complexes
0.0 0.2 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 0.2 REACTOME ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS Genes involved in Acetylcholine Binding And Downstream Events
0.0 0.0 REACTOME PLATELET SENSITIZATION BY LDL Genes involved in Platelet sensitization by LDL