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ENCODE: H3K4me1 ChIP-Seq of primary human cells
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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for PTF1A

Z-value: 1.00

Motif logo

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Transcription factors associated with PTF1A

Gene Symbol Gene ID Gene Info
PTF1A
ENSG00000168267.5 PTF1A

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
PTF1Achr10_23482276_2348242710950.5268680.646.4e-02Click!
PTF1Achr10_23488995_2348914678140.201339-0.363.4e-01Click!
PTF1Achr10_23488268_2348841970870.2043100.343.7e-01Click!
PTF1Achr10_23481305_234816462190.9389870.333.8e-01Click!
PTF1Achr10_23480399_234807017060.6955700.304.4e-01Click!

Activity of the PTF1A motif across conditions

Conditions sorted by the z-value of the PTF1A motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr12_67850341_67850497 0.24 CAND1
 cullin-associated and neddylation-dissociated 1
 157667
 0.04
chr13_42163465_42163616 0.21 ENSG00000264190
 .
 21009
 0.24
chr22_46942997_46943353 0.19 RP3-439F8.1
5783
 0.21
chr2_113471224_113471441 0.19 NT5DC4
 5'-nucleotidase domain containing 4
 7731
 0.2
chr5_400384_400594 0.18 AHRR
 aryl-hydrocarbon receptor repressor
 20546
 0.14
chr7_92392888_92393108 0.18 ENSG00000206763
 .
 61870
 0.11
chr10_21625403_21625600 0.17 ENSG00000207264
 .
 14611
 0.25
chr5_159107_159571 0.17 ENSG00000199540
 .
 15027
 0.14
chr8_79037834_79037985 0.16 ENSG00000252935
 .
 272948
 0.02
chr6_1481841_1482247 0.16 ENSG00000243439
 .
 25513
 0.23
chr12_15803315_15803614 0.16 EPS8
 epidermal growth factor receptor pathway substrate 8
 11744
 0.22
chr10_123337096_123337247 0.16 FGFR2
 fibroblast growth factor receptor 2
 16172
 0.28
chr3_126326535_126326709 0.16 TXNRD3NB
 thioredoxin reductase 3 neighbor
 776
 0.53
chr5_32234391_32234706 0.16 ENSG00000199731
 .
 433
 0.85
chr10_21688273_21688424 0.16 ENSG00000207264
 .
 77458
 0.08
chr12_49174131_49174365 0.16 ADCY6
 adenylate cyclase 6
 2041
 0.18
chr21_44914867_44915123 0.16 SIK1
 salt-inducible kinase 1
 67987
 0.12
chr15_75986048_75986554 0.16 AC105020.1
 Uncharacterized protein; cDNA FLJ12988 fis, clone NT2RP3000080
 15629
 0.09
chr21_40225929_40226080 0.16 ENSG00000272015
 .
 40705
 0.18
chr12_109096320_109096777 0.16 CORO1C
 coronin, actin binding protein, 1C
 226
 0.92
chr17_60729376_60729765 0.15 ENSG00000207382
 .
 9516
 0.17
chr3_129328950_129329208 0.15 PLXND1
 plexin D1
 3418
 0.22
chr11_68109658_68109959 0.15 LRP5
 low density lipoprotein receptor-related protein 5
 29731
 0.18
chr16_17565693_17566047 0.15 XYLT1
 xylosyltransferase I
 1132
 0.68
chr5_77793836_77794265 0.15 LHFPL2
 lipoma HMGIC fusion partner-like 2
 50924
 0.17
chr19_11379736_11379971 0.15 DOCK6
 dedicator of cytokinesis 6
 6725
 0.11
chr10_93870631_93870837 0.15 ENSG00000252993
 .
 34735
 0.16
chr11_75314249_75314547 0.15 CTD-2530H12.8
6083
 0.15
chr3_155052084_155052404 0.14 ENSG00000272096
 .
 103368
 0.07
chr1_116213820_116213971 0.14 VANGL1
 VANGL planar cell polarity protein 1
 19872
 0.2
chr5_179562384_179562580 0.14 RASGEF1C
 RasGEF domain family, member 1C
 1294
 0.52
chr2_27300827_27300990 0.14 EMILIN1
 elastin microfibril interfacer 1
 527
 0.53
chr2_17826971_17827297 0.14 VSNL1
 visinin-like 1
 104707
 0.07
chr10_95706682_95706833 0.14 PLCE1
 phospholipase C, epsilon 1
 46989
 0.14
chr13_114540098_114540530 0.14 GAS6
 growth arrest-specific 6
 1297
 0.5
chr12_13360289_13360515 0.14 EMP1
 epithelial membrane protein 1
 4043
 0.3
chr20_43201295_43201704 0.14 PKIG
 protein kinase (cAMP-dependent, catalytic) inhibitor gamma
 9691
 0.16
chr1_27868563_27868910 0.14 RP1-159A19.4
16420
 0.16
chr20_48602354_48602703 0.14 SNAI1
 snail family zinc finger 1
 2992
 0.21
chr11_57545504_57545726 0.14 CTNND1
 catenin (cadherin-associated protein), delta 1
 3460
 0.19
chr11_47628458_47628609 0.14 ENSG00000223187
 .
 8013
 0.09
chr2_36603812_36603963 0.14 CRIM1
 cysteine rich transmembrane BMP regulator 1 (chordin-like)
 20273
 0.27
chr9_131285828_131285979 0.14 GLE1
 GLE1 RNA export mediator
 18818
 0.09
chr2_111829443_111829704 0.14 AC096670.3
42189
 0.17
chr6_16741600_16742258 0.14 RP1-151F17.1
19440
 0.23
chr12_2736655_2736806 0.14 CACNA1C-AS3
 CACNA1C antisense RNA 3
 20124
 0.19
chr3_52162372_52162604 0.13 POC1A
 POC1 centriolar protein A
 25932
 0.12
chr3_120151791_120151942 0.13 FSTL1
 follistatin-like 1
 17972
 0.23
chr10_33530111_33530697 0.13 NRP1
 neuropilin 1
 22228
 0.19
chr1_221885101_221885678 0.13 DUSP10
 dual specificity phosphatase 10
 25413
 0.27
chr17_42872109_42872587 0.13 GJC1
 gap junction protein, gamma 1, 45kDa
 9986
 0.14
chr17_27043552_27043710 0.13 RAB34
 RAB34, member RAS oncogene family
 1135
 0.17
chr3_39106471_39106797 0.13 WDR48
 WD repeat domain 48
 12842
 0.17
chr6_33739173_33739324 0.13 LEMD2
 LEM domain containing 2
 5673
 0.17
chr7_73891950_73892160 0.13 ENSG00000238391
 .
 9815
 0.21
chr10_79051340_79051491 0.13 RP11-328K22.1
22284
 0.23
chr1_208396345_208396507 0.13 PLXNA2
 plexin A2
 21239
 0.29
chr14_23320919_23321446 0.13 ENSG00000212335
 .
 755
 0.41
chr1_33847797_33848128 0.13 PHC2
 polyhomeotic homolog 2 (Drosophila)
 6768
 0.16
chr8_50967932_50968107 0.13 SNTG1
 syntrophin, gamma 1
 143314
 0.05
chr2_216638728_216639015 0.13 ENSG00000212055
 .
 104771
 0.08
chr6_132451757_132451908 0.13 ENSG00000265669
 .
 15429
 0.28
chr12_57540629_57540857 0.13 RP11-545N8.3
569
 0.61
chr9_124650254_124650616 0.13 RP11-244O19.1
68704
 0.12
chr5_139049066_139049545 0.13 CXXC5
 CXXC finger protein 5
 5716
 0.23
chr14_34645241_34645392 0.13 EGLN3
 egl-9 family hypoxia-inducible factor 3
 46767
 0.18
chr2_45405796_45405979 0.12 SIX2
 SIX homeobox 2
 169318
 0.04
chr17_63095498_63095706 0.12 RGS9
 regulator of G-protein signaling 9
 37964
 0.14
chr22_22392769_22392920 0.12 IGLV10-67
 immunoglobulin lambda variable 10-67 (pseudogene)
 5172
 0.08
chr1_113065501_113065652 0.12 RP4-671G15.2
4513
 0.21
chr12_50031208_50031359 0.12 PRPF40B
 PRP40 pre-mRNA processing factor 40 homolog B (S. cerevisiae)
 6956
 0.16
chr2_62521235_62521386 0.12 ENSG00000238809
 .
 29180
 0.17
chr17_2310928_2311079 0.12 MNT
 MAX network transcriptional repressor
 6591
 0.12
chr2_204310238_204310402 0.12 RAPH1
 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1
 49756
 0.15
chr17_40562098_40562486 0.12 ENSG00000221020
 .
 11265
 0.11
chr6_75287505_75287734 0.12 ENSG00000264884
 .
 141940
 0.05
chr21_47486468_47486686 0.12 AP001471.1
30867
 0.13
chr10_102761652_102761861 0.12 LZTS2
 leucine zipper, putative tumor suppressor 2
 2146
 0.16
chr15_52387293_52387444 0.12 CTD-2184D3.5
5352
 0.17
chr10_59782900_59783051 0.12 ENSG00000238970
 .
 215546
 0.02
chr20_25207702_25207867 0.12 AL035252.1
 HCG2018895; Uncharacterized protein
 414
 0.81
chr16_19117644_19117795 0.12 ITPRIPL2
 inositol 1,4,5-trisphosphate receptor interacting protein-like 2
 7535
 0.16
chr1_95135129_95135280 0.12 ENSG00000263526
 .
 76252
 0.1
chr11_65247002_65247484 0.12 AP000769.1
 Uncharacterized protein
 24515
 0.1
chr11_47437227_47437644 0.12 SLC39A13
 solute carrier family 39 (zinc transporter), member 13
 5799
 0.09
chr2_100498763_100498929 0.12 AFF3
 AF4/FMR2 family, member 3
 222146
 0.02
chr12_122441567_122441769 0.12 BCL7A
 B-cell CLL/lymphoma 7A
 15660
 0.2
chr2_43478575_43478821 0.12 AC010883.5
21986
 0.21
chr18_10851313_10851599 0.12 PIEZO2
 piezo-type mechanosensitive ion channel component 2
 3978
 0.31
chr8_141640294_141640461 0.12 AGO2
 argonaute RISC catalytic component 2
 5268
 0.25
chr10_80937857_80938019 0.12 ZMIZ1
 zinc finger, MIZ-type containing 1
 109146
 0.07
chr14_52500228_52500379 0.12 NID2
 nidogen 2 (osteonidogen)
 5367
 0.2
chr5_77800136_77800667 0.12 LHFPL2
 lipoma HMGIC fusion partner-like 2
 44573
 0.19
chr22_22751862_22752013 0.12 IGLVI-42
 immunoglobulin lambda variable (I)-42 (pseudogene)
 568
 0.4
chr21_39221535_39221777 0.12 KCNJ6
 potassium inwardly-rectifying channel, subfamily J, member 6
 63901
 0.13
chr20_4323206_4323357 0.12 ADRA1D
 adrenoceptor alpha 1D
 93560
 0.08
chr15_89287914_89288065 0.12 ACAN
 aggrecan
 58685
 0.12
chr2_46122892_46123236 0.12 PRKCE
 protein kinase C, epsilon
 104977
 0.07
chr5_75698742_75698904 0.12 IQGAP2
 IQ motif containing GTPase activating protein 2
 251
 0.95
chr17_17669783_17670067 0.12 RAI1-AS1
 RAI1 antisense RNA 1
 4210
 0.15
chr18_20807553_20807816 0.12 RP11-17J14.2
32634
 0.18
chr2_40165474_40165639 0.12 SLC8A1-AS1
 SLC8A1 antisense RNA 1
 18723
 0.29
chr10_49816143_49816294 0.11 ARHGAP22
 Rho GTPase activating protein 22
 3080
 0.28
chr13_34094163_34094315 0.11 STARD13
 StAR-related lipid transfer (START) domain containing 13
 169472
 0.03
chr1_16478132_16478294 0.11 RP11-276H7.2
3493
 0.15
chr18_53841377_53841528 0.11 ENSG00000201816
 .
 94627
 0.1
chr22_37908037_37908429 0.11 CARD10
 caspase recruitment domain family, member 10
 15
 0.97
chr9_97690813_97690964 0.11 RP11-54O15.3
6340
 0.2
chr12_116820513_116820722 0.11 ENSG00000264037
 .
 45506
 0.17
chr19_13147816_13148089 0.11 NFIX
 nuclear factor I/X (CCAAT-binding transcription factor)
 12141
 0.1
chr3_45595189_45595741 0.11 ENSG00000251927
 .
 38282
 0.14
chr3_149089347_149089529 0.11 TM4SF1
 transmembrane 4 L six family member 1
 4061
 0.21
chr12_57845396_57845698 0.11 INHBE
 inhibin, beta E
 2939
 0.12
chr4_87889842_87889993 0.11 AFF1
 AF4/FMR2 family, member 1
 32355
 0.19
chr2_36680002_36680153 0.11 CRIM1
 cysteine rich transmembrane BMP regulator 1 (chordin-like)
 60756
 0.12
chr10_33548336_33548487 0.11 NRP1
 neuropilin 1
 4221
 0.26
chr3_87007607_87007758 0.11 VGLL3
 vestigial like 3 (Drosophila)
 32170
 0.25
chr3_151553926_151554105 0.11 AADAC
 arylacetamide deacetylase
 22154
 0.19
chr10_42737228_42737379 0.11 ENSG00000264398
 .
 6880
 0.28
chr16_57869184_57869335 0.11 ENSG00000206833
 .
 4713
 0.16
chr1_110201098_110201511 0.11 GSTM4
 glutathione S-transferase mu 4
 2346
 0.15
chr14_35726780_35727196 0.11 PSMA6
 proteasome (prosome, macropain) subunit, alpha type, 6
 20851
 0.2
chr2_19811954_19812105 0.11 OSR1
 odd-skipped related transciption factor 1
 253615
 0.02
chr15_50123497_50124106 0.11 ATP8B4
 ATPase, class I, type 8B, member 4
 45091
 0.15
chr3_193995114_193995363 0.11 CPN2
 carboxypeptidase N, polypeptide 2
 76809
 0.09
chr4_145703678_145703971 0.11 HHIP-AS1
 HHIP antisense RNA 1
 121315
 0.06
chr1_202561131_202561282 0.11 RP11-569A11.1
12190
 0.21
chr11_126211911_126212298 0.11 ST3GAL4
 ST3 beta-galactoside alpha-2,3-sialyltransferase 4
 13451
 0.13
chr1_235133357_235133864 0.11 ENSG00000239690
 .
 93677
 0.08
chr8_49322257_49322678 0.11 ENSG00000252710
 .
 101877
 0.08
chr5_152602797_152602948 0.11 GRIA1
 glutamate receptor, ionotropic, AMPA 1
 267234
 0.02
chr10_44426237_44426570 0.11 ENSG00000238957
 .
 103585
 0.08
chr7_112124918_112125112 0.11 LSMEM1
 leucine-rich single-pass membrane protein 1
 3969
 0.27
chr18_45967451_45967809 0.11 ZBTB7C
 zinc finger and BTB domain containing 7C
 30507
 0.17
chr13_51640594_51641011 0.11 ENSG00000222920
 .
 38814
 0.19
chr10_87985253_87985463 0.11 ENSG00000199104
 .
 39187
 0.19
chr13_40605647_40605830 0.11 ENSG00000212553
 .
 174374
 0.03
chr16_70774609_70775132 0.11 VAC14
 Vac14 homolog (S. cerevisiae)
 3613
 0.18
chr7_116712956_116713196 0.11 ST7-AS2
 ST7 antisense RNA 2
 1702
 0.37
chr14_64676817_64676968 0.11 SYNE2
 spectrin repeat containing, nuclear envelope 2
 850
 0.69
chr2_218768941_218769167 0.11 TNS1
 tensin 1
 518
 0.85
chr10_79175435_79175586 0.11 KCNMA1
 potassium large conductance calcium-activated channel, subfamily M, alpha member 1
 11768
 0.26
chr10_5855812_5855963 0.11 GDI2
 GDP dissociation inhibitor 2
 375
 0.87
chr14_50438697_50439507 0.11 C14orf182
 chromosome 14 open reading frame 182
 35136
 0.13
chr10_71239313_71239464 0.11 TSPAN15
 tetraspanin 15
 4236
 0.26
chr4_16600587_16600738 0.11 LDB2
 LIM domain binding 2
 3164
 0.4
chr6_31430757_31430908 0.11 HCP5
 HLA complex P5 (non-protein coding)
 130
 0.92
chr1_168196938_168197651 0.11 SFT2D2
 SFT2 domain containing 2
 2039
 0.33
chr3_45684381_45684734 0.11 LIMD1-AS1
 LIMD1 antisense RNA 1
 45817
 0.11
chr7_17573125_17573276 0.11 ENSG00000199473
 .
 160250
 0.04
chr2_204547534_204547685 0.11 CD28
 CD28 molecule
 23589
 0.23
chr14_75744170_75744695 0.11 FOS
 FBJ murine osteosarcoma viral oncogene homolog
 1045
 0.48
chr5_266043_266334 0.11 CTD-2083E4.6
5443
 0.15
chr14_66548486_66548770 0.11 ENSG00000238876
 .
 70177
 0.12
chr10_134498665_134499079 0.11 INPP5A
 inositol polyphosphate-5-phosphatase, 40kDa
 77442
 0.1
chr5_88028283_88028662 0.11 CTC-467M3.2
40004
 0.16
chr18_46247595_46247746 0.11 RP11-426J5.2
32880
 0.19
chr18_20872310_20872461 0.11 RP11-17J14.2
32067
 0.2
chr17_76330977_76331356 0.11 SOCS3
 suppressor of cytokine signaling 3
 24989
 0.13
chr5_58905748_58906023 0.11 PDE4D
 phosphodiesterase 4D, cAMP-specific
 23560
 0.27
chr18_20808297_20808526 0.11 RP11-17J14.2
31907
 0.19
chr5_55705699_55705933 0.11 ENSG00000265665
 .
 47149
 0.15
chr2_121507866_121508017 0.11 GLI2
 GLI family zinc finger 2
 14118
 0.28
chr4_41415593_41415744 0.11 LIMCH1
 LIM and calponin homology domains 1
 27672
 0.23
chr5_139049687_139050600 0.11 CXXC5
 CXXC finger protein 5
 4878
 0.24
chr2_237982404_237982555 0.11 COPS8
 COP9 signalosome subunit 8
 11476
 0.18
chr3_70881757_70881908 0.11 ENSG00000206939
 .
 24331
 0.24
chr6_37128475_37128981 0.11 PIM1
 pim-1 oncogene
 9251
 0.19
chr2_47307144_47307295 0.11 AC073283.7
12258
 0.2
chr1_20390234_20390385 0.11 PLA2G5
 phospholipase A2, group V
 6392
 0.2
chr15_59641636_59642058 0.11 ENSG00000199512
 .
 8231
 0.13
chr14_55120909_55121243 0.10 SAMD4A
 sterile alpha motif domain containing 4A
 86439
 0.09
chr3_48869954_48870105 0.10 PRKAR2A-AS1
 PRKAR2A antisense RNA 1
 14976
 0.13
chr20_60328734_60328885 0.10 RP11-429E11.2
1272
 0.55
chr10_78303256_78303407 0.10 RP11-325D15.2
17421
 0.27
chr20_49092272_49092440 0.10 PTPN1
 protein tyrosine phosphatase, non-receptor type 1
 34535
 0.14
chr14_54810734_54810960 0.10 CDKN3
 cyclin-dependent kinase inhibitor 3
 52826
 0.16
chr11_28364524_28364785 0.10 ENSG00000222385
 .
 81588
 0.11
chr15_74318131_74318282 0.10 PML
 promyelocytic leukemia
 985
 0.5
chr4_169787971_169788122 0.10 ENSG00000201176
 .
 18460
 0.19
chr12_57384946_57385313 0.10 GPR182
 G protein-coupled receptor 182
 3101
 0.13
chr1_110786365_110786665 0.10 ENSG00000200536
 .
 28591
 0.11
chr4_138957376_138957527 0.10 ENSG00000250033
 .
 21167
 0.29
chr10_13388032_13388925 0.10 SEPHS1
 selenophosphate synthetase 1
 880
 0.59
chr10_14020202_14020353 0.10 FRMD4A
 FERM domain containing 4A
 5908
 0.24
chr12_47408609_47408796 0.10 PCED1B
 PC-esterase domain containing 1B
 64684
 0.12
chr3_106784181_106784490 0.10 ENSG00000252626
 .
 57920
 0.17
chr9_98225410_98225961 0.10 PTCH1
 patched 1
 17082
 0.18
chr9_139081692_139081843 0.10 LHX3
 LIM homeobox 3
 13237
 0.18
chr5_86410503_86410654 0.10 ENSG00000265919
 .
 193
 0.96
chr10_105408529_105408680 0.10 SH3PXD2A
 SH3 and PX domains 2A
 12858
 0.17
chr17_55559057_55559208 0.10 RP11-118E18.2
41826
 0.16
chr1_97608805_97609099 0.10 DPYD-AS1
 DPYD antisense RNA 1
 47473
 0.2
chr8_22844784_22844935 0.10 RHOBTB2
 Rho-related BTB domain containing 2
 71
 0.96
chrX_46303733_46303884 0.10 KRBOX4
 KRAB box domain containing 4
 2484
 0.38
chr22_39688298_39688455 0.10 RP3-333H23.8
617
 0.6
chr3_132683248_132683399 0.10 TMEM108
 transmembrane protein 108
 73912
 0.12
chr14_53478340_53478491 0.10 RP11-368P15.3
25058
 0.21
chr3_42531570_42531721 0.10 VIPR1
 vasoactive intestinal peptide receptor 1
 854
 0.59
chr2_135532341_135532658 0.10 TMEM163
 transmembrane protein 163
 55929
 0.13

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

StringDB image

First level regulatory network of PTF1A

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0060831 smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:0060831)
0.0 0.1 GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.0 0.1 GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway(GO:0010803)
0.0 0.0 GO:0048702 embryonic neurocranium morphogenesis(GO:0048702)
0.0 0.2 GO:0007028 cytoplasm organization(GO:0007028)
0.0 0.2 GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.0 0.1 GO:0060083 smooth muscle contraction involved in micturition(GO:0060083)
0.0 0.1 GO:0001543 ovarian follicle rupture(GO:0001543)
0.0 0.1 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.0 0.1 GO:0060013 righting reflex(GO:0060013)
0.0 0.1 GO:0048149 behavioral response to ethanol(GO:0048149)
0.0 0.1 GO:0017085 response to insecticide(GO:0017085)
0.0 0.1 GO:0014834 skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration(GO:0014834)
0.0 0.1 GO:0035583 sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.0 0.1 GO:0031053 primary miRNA processing(GO:0031053)
0.0 0.1 GO:0046952 ketone body catabolic process(GO:0046952)
0.0 0.1 GO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.0 0.1 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
0.0 0.1 GO:0032344 regulation of ketone biosynthetic process(GO:0010566) regulation of aldosterone metabolic process(GO:0032344) regulation of aldosterone biosynthetic process(GO:0032347)
0.0 0.1 GO:0007144 female meiosis I(GO:0007144)
0.0 0.1 GO:0090084 negative regulation of inclusion body assembly(GO:0090084)
0.0 0.1 GO:0021535 cell migration in hindbrain(GO:0021535)
0.0 0.0 GO:0060433 bronchus development(GO:0060433)
0.0 0.0 GO:0060449 bud elongation involved in lung branching(GO:0060449)
0.0 0.1 GO:0060638 mesenchymal-epithelial cell signaling(GO:0060638)
0.0 0.1 GO:0010842 retina layer formation(GO:0010842)
0.0 0.1 GO:0070874 negative regulation of glycogen metabolic process(GO:0070874)
0.0 0.1 GO:0006910 phagocytosis, recognition(GO:0006910)
0.0 0.1 GO:0070050 neuron cellular homeostasis(GO:0070050)
0.0 0.1 GO:0060743 epithelial cell maturation involved in prostate gland development(GO:0060743)
0.0 0.1 GO:0090286 cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.0 0.1 GO:0070208 protein heterotrimerization(GO:0070208)
0.0 0.1 GO:0007412 axon target recognition(GO:0007412)
0.0 0.1 GO:0022010 central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291)
0.0 0.1 GO:0048625 myoblast fate commitment(GO:0048625)
0.0 0.0 GO:0090083 regulation of inclusion body assembly(GO:0090083)
0.0 0.1 GO:0032055 negative regulation of translation in response to stress(GO:0032055)
0.0 0.1 GO:0033173 calcineurin-NFAT signaling cascade(GO:0033173)
0.0 0.4 GO:0048286 lung alveolus development(GO:0048286)
0.0 0.0 GO:0046628 positive regulation of insulin receptor signaling pathway(GO:0046628) positive regulation of cellular response to insulin stimulus(GO:1900078)
0.0 0.1 GO:0007258 JUN phosphorylation(GO:0007258)
0.0 0.0 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 0.0 GO:0048875 surfactant homeostasis(GO:0043129) chemical homeostasis within a tissue(GO:0048875)
0.0 0.0 GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463) maturation of LSU-rRNA(GO:0000470)
0.0 0.1 GO:0048843 negative regulation of axon extension involved in axon guidance(GO:0048843)
0.0 0.0 GO:0060014 granulosa cell differentiation(GO:0060014)
0.0 0.0 GO:0070427 nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427)
0.0 0.0 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.0 0.0 GO:0042637 catagen(GO:0042637)
0.0 0.0 GO:0010701 positive regulation of norepinephrine secretion(GO:0010701)
0.0 0.0 GO:0045112 integrin biosynthetic process(GO:0045112)
0.0 0.0 GO:0021800 cerebral cortex tangential migration(GO:0021800)
0.0 0.0 GO:1902668 negative regulation of axon guidance(GO:1902668)
0.0 0.1 GO:0048539 bone marrow development(GO:0048539)
0.0 0.1 GO:0051409 response to nitrosative stress(GO:0051409)
0.0 0.1 GO:0043615 astrocyte cell migration(GO:0043615)
0.0 0.0 GO:0061318 renal filtration cell differentiation(GO:0061318) glomerular epithelium development(GO:0072010) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.0 0.0 GO:0048865 stem cell fate commitment(GO:0048865) stem cell fate determination(GO:0048867)
0.0 0.1 GO:0071731 response to nitric oxide(GO:0071731)
0.0 0.1 GO:0042363 vitamin catabolic process(GO:0009111) fat-soluble vitamin catabolic process(GO:0042363)
0.0 0.1 GO:0070570 regulation of axon regeneration(GO:0048679) regulation of neuron projection regeneration(GO:0070570)
0.0 0.1 GO:0033600 negative regulation of mammary gland epithelial cell proliferation(GO:0033600)
0.0 0.0 GO:0051771 negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771)
0.0 0.0 GO:1903332 regulation of protein folding(GO:1903332)
0.0 0.0 GO:0021615 glossopharyngeal nerve development(GO:0021563) glossopharyngeal nerve morphogenesis(GO:0021615)
0.0 0.0 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.0 0.0 GO:0071421 manganese ion transmembrane transport(GO:0071421)
0.0 0.0 GO:0030011 maintenance of cell polarity(GO:0030011)
0.0 0.0 GO:0030505 inorganic diphosphate transport(GO:0030505)
0.0 0.0 GO:0017121 phospholipid scrambling(GO:0017121)
0.0 0.0 GO:0010715 regulation of extracellular matrix disassembly(GO:0010715) negative regulation of extracellular matrix disassembly(GO:0010716) regulation of extracellular matrix organization(GO:1903053) negative regulation of extracellular matrix organization(GO:1903054)
0.0 0.0 GO:0001955 blood vessel maturation(GO:0001955)
0.0 0.0 GO:0060999 positive regulation of dendritic spine development(GO:0060999)
0.0 0.0 GO:0044240 multicellular organism lipid catabolic process(GO:0044240)
0.0 0.1 GO:0048840 otolith development(GO:0048840)
0.0 0.1 GO:0030321 transepithelial chloride transport(GO:0030321)
0.0 0.0 GO:0031659 regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle(GO:0031657) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle(GO:0031659)
0.0 0.1 GO:0070168 negative regulation of biomineral tissue development(GO:0070168)
0.0 0.0 GO:0001778 plasma membrane repair(GO:0001778)
0.0 0.0 GO:0048845 venous blood vessel morphogenesis(GO:0048845)
0.0 0.0 GO:0045721 negative regulation of gluconeogenesis(GO:0045721)
0.0 0.1 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.0 0.0 GO:0002238 response to molecule of fungal origin(GO:0002238)
0.0 0.0 GO:0014832 urinary bladder smooth muscle contraction(GO:0014832)
0.0 0.0 GO:0002085 inhibition of neuroepithelial cell differentiation(GO:0002085)
0.0 0.0 GO:0090073 positive regulation of protein homodimerization activity(GO:0090073)
0.0 0.1 GO:0018214 peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214)
0.0 0.0 GO:0043276 anoikis(GO:0043276)
0.0 0.0 GO:0072386 plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.0 0.1 GO:0050922 negative regulation of chemotaxis(GO:0050922)
0.0 0.1 GO:0015701 bicarbonate transport(GO:0015701)
0.0 0.0 GO:0007000 nucleolus organization(GO:0007000)
0.0 0.1 GO:0061081 positive regulation of myeloid leukocyte cytokine production involved in immune response(GO:0061081)
0.0 0.0 GO:0032926 negative regulation of activin receptor signaling pathway(GO:0032926)
0.0 0.0 GO:0007386 compartment pattern specification(GO:0007386)
0.0 0.0 GO:0030952 establishment or maintenance of cytoskeleton polarity(GO:0030952)
0.0 0.1 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
0.0 0.1 GO:0048844 artery morphogenesis(GO:0048844)
0.0 0.0 GO:0010966 regulation of phosphate transport(GO:0010966)
0.0 0.0 GO:0030091 protein repair(GO:0030091)
0.0 0.1 GO:0055003 cardiac myofibril assembly(GO:0055003)
0.0 0.1 GO:0009629 response to gravity(GO:0009629)
0.0 0.0 GO:0070307 lens fiber cell development(GO:0070307)
0.0 0.0 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
0.0 0.0 GO:0032455 nerve growth factor processing(GO:0032455)
0.0 0.0 GO:0046813 receptor-mediated virion attachment to host cell(GO:0046813)
0.0 0.0 GO:0051124 synaptic growth at neuromuscular junction(GO:0051124)
0.0 0.0 GO:0060535 trachea cartilage morphogenesis(GO:0060535) cartilage morphogenesis(GO:0060536)
0.0 0.0 GO:0071502 cellular response to temperature stimulus(GO:0071502)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0032449 CBM complex(GO:0032449)
0.0 0.1 GO:0070852 cell body fiber(GO:0070852)
0.0 0.2 GO:0031512 motile primary cilium(GO:0031512)
0.0 0.1 GO:0048179 activin receptor complex(GO:0048179)
0.0 0.1 GO:0071437 invadopodium(GO:0071437)
0.0 0.1 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.0 0.1 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.1 GO:0098647 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0 0.1 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.1 GO:0034992 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 0.1 GO:0031312 extrinsic component of organelle membrane(GO:0031312)
0.0 0.0 GO:0016600 flotillin complex(GO:0016600)
0.0 0.1 GO:0042629 mast cell granule(GO:0042629)
0.0 0.1 GO:0016942 insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454)
0.0 0.1 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.0 0.1 GO:0030061 mitochondrial crista(GO:0030061)
0.0 0.0 GO:0005588 collagen type V trimer(GO:0005588)
0.0 0.1 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.0 GO:0043259 laminin-10 complex(GO:0043259)
0.0 0.1 GO:0005593 FACIT collagen trimer(GO:0005593)
0.0 0.1 GO:0030904 retromer complex(GO:0030904)
0.0 0.0 GO:0070545 PeBoW complex(GO:0070545)
0.0 0.1 GO:0005915 zonula adherens(GO:0005915)
0.0 0.2 GO:0008328 ionotropic glutamate receptor complex(GO:0008328) neurotransmitter receptor complex(GO:0098878)
0.0 0.2 GO:0031528 microvillus membrane(GO:0031528)
0.0 0.1 GO:0070822 Sin3 complex(GO:0016580) Sin3-type complex(GO:0070822)
0.0 0.0 GO:0042825 TAP complex(GO:0042825)
0.0 0.0 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.0 0.0 GO:0033643 host(GO:0018995) host cell part(GO:0033643) host intracellular part(GO:0033646) intracellular region of host(GO:0043656) host cell(GO:0043657) other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217)
0.0 0.0 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.0 0.0 GO:0071664 catenin-TCF7L2 complex(GO:0071664)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0000987 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.0 0.1 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.0 0.1 GO:0097493 extracellular matrix constituent conferring elasticity(GO:0030023) structural molecule activity conferring elasticity(GO:0097493)
0.0 0.2 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.1 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.0 0.2 GO:0008266 poly(U) RNA binding(GO:0008266)
0.0 0.1 GO:0050508 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.0 0.1 GO:0000293 ferric-chelate reductase activity(GO:0000293)
0.0 0.2 GO:0070696 transmembrane receptor protein serine/threonine kinase binding(GO:0070696)
0.0 0.1 GO:0042285 UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285)
0.0 0.1 GO:0048018 receptor agonist activity(GO:0048018)
0.0 0.1 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.0 0.1 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0 0.1 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.0 0.1 GO:0050897 cobalt ion binding(GO:0050897)
0.0 0.1 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0 0.1 GO:0016933 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.0 0.1 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.1 GO:0005010 insulin-like growth factor-activated receptor activity(GO:0005010)
0.0 0.2 GO:0005112 Notch binding(GO:0005112)
0.0 0.1 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.0 0.1 GO:0004705 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0 0.1 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.0 0.1 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0 0.1 GO:0045499 chemorepellent activity(GO:0045499)
0.0 0.1 GO:0050682 AF-2 domain binding(GO:0050682)
0.0 0.1 GO:0004800 thyroxine 5'-deiodinase activity(GO:0004800)
0.0 0.1 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.1 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0 0.1 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017)
0.0 0.1 GO:0003680 AT DNA binding(GO:0003680)
0.0 0.1 GO:0046980 tapasin binding(GO:0046980)
0.0 0.1 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0 0.1 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.1 GO:0003872 6-phosphofructokinase activity(GO:0003872)
0.0 0.1 GO:0004791 thioredoxin-disulfide reductase activity(GO:0004791)
0.0 0.0 GO:0001099 basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.0 0.0 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0 0.1 GO:0004470 malic enzyme activity(GO:0004470)
0.0 0.0 GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.0 0.2 GO:0051721 protein phosphatase 2A binding(GO:0051721)
0.0 0.0 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.1 GO:0050811 GABA receptor binding(GO:0050811)
0.0 0.1 GO:0030371 translation repressor activity(GO:0030371)
0.0 0.1 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0 0.1 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.0 0.0 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.0 0.0 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.0 0.1 GO:0048406 nerve growth factor binding(GO:0048406)
0.0 0.1 GO:0030507 spectrin binding(GO:0030507)
0.0 0.0 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.1 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624) ubiquitin-like protein conjugating enzyme binding(GO:0044390)
0.0 0.1 GO:0050780 dopamine receptor binding(GO:0050780)
0.0 0.1 GO:0005110 frizzled-2 binding(GO:0005110)
0.0 0.0 GO:0032554 purine deoxyribonucleotide binding(GO:0032554) adenyl deoxyribonucleotide binding(GO:0032558)
0.0 0.0 GO:0016623 oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor(GO:0016623)
0.0 0.0 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.0 0.1 GO:0050998 nitric-oxide synthase binding(GO:0050998)
0.0 0.1 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.0 0.1 GO:0009374 biotin binding(GO:0009374)
0.0 0.0 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0 0.0 GO:0004999 vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.0 0.0 GO:0016454 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0 0.0 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.0 0.1 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.0 GO:0016361 activin receptor activity, type I(GO:0016361)
0.0 0.1 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 0.1 GO:0017166 vinculin binding(GO:0017166)
0.0 0.0 GO:0004937 alpha1-adrenergic receptor activity(GO:0004937)
0.0 0.1 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0 0.0 GO:0032190 acrosin binding(GO:0032190)
0.0 0.0 GO:0070644 vitamin D response element binding(GO:0070644)
0.0 0.1 GO:0005521 lamin binding(GO:0005521)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 PID S1P META PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.0 0.2 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.0 0.2 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.0 REACTOME PLC BETA MEDIATED EVENTS Genes involved in PLC beta mediated events
0.0 0.0 REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR Genes involved in Prostacyclin signalling through prostacyclin receptor
0.0 0.3 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.0 REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR Genes involved in Thromboxane signalling through TP receptor
0.0 0.4 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.3 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.0 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.0 0.3 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 0.0 REACTOME G ALPHA Z SIGNALLING EVENTS Genes involved in G alpha (z) signalling events
0.0 0.0 REACTOME GPCR LIGAND BINDING Genes involved in GPCR ligand binding
0.0 0.2 REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.0 0.1 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.3 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.0 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.0 0.1 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.0 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 0.1 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.0 REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII