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ENCODE: H3K4me1 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for RBPJ

Z-value: 0.44

Motif logo

Transcription factors associated with RBPJ

Gene Symbol	Gene ID	Gene Info
RBPJ Ensembl NCBI GeneCards UniProt	ENSG00000168214.16	RBPJ

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
RBPJ	chr4_26454784_26454935	24517	0.215697	0.91	7.4e-04	Click!
RBPJ	chr4_26198232_26198383	33230	0.242958	-0.80	1.0e-02	Click!
RBPJ	chr4_26459444_26459886	29323	0.197982	0.80	1.0e-02	Click!
RBPJ	chr4_26387680_26387953	23664	0.257737	-0.77	1.5e-02	Click!
RBPJ	chr4_26300891_26301042	20318	0.282335	-0.75	2.0e-02	Click!

Activity of the RBPJ motif across conditions

Conditions sorted by the z-value of the RBPJ motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr7_140542463_140542763	0.09	ENSG00000271932	.	41259	0.15
chr3_112115394_112115545	0.08	CD200	CD200 molecule	63444	0.12
chr3_71585804_71586230	0.08	ENSG00000221264	.	5223	0.23
chr2_66706378_66706529	0.08	MEIS1	Meis homeobox 1	29606	0.16
chr4_55684754_55684905	0.08	KIT	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	160744	0.04
chr2_46067140_46067427	0.08	PRKCE	protein kinase C, epsilon	160758	0.04
chr5_149524173_149524324	0.07	PDGFRB	platelet-derived growth factor receptor, beta polypeptide	7248	0.15
chr3_184503248_184503626	0.07	VPS8	vacuolar protein sorting 8 homolog (S. cerevisiae)	26494	0.22
chr9_127520364_127520515	0.07	RP11-175D17.3		11963	0.14
chr2_20795415_20795848	0.07	HS1BP3-IT1	HS1BP3 intronic transcript 1 (non-protein coding)	3323	0.28
chr18_7116494_7116699	0.07	LAMA1	laminin, alpha 1	1217	0.55
chr15_65010591_65010969	0.07	OAZ2	ornithine decarboxylase antizyme 2	15300	0.11
chr21_46677673_46677824	0.06	POFUT2	protein O-fucosyltransferase 2	27858	0.16
chr12_5310016_5310167	0.06	KCNA5	potassium voltage-gated channel, shaker-related subfamily, member 5	157006	0.04
chr2_68499522_68499673	0.06	ENSG00000221443	.	639	0.65
chr15_89565634_89565983	0.06	ENSG00000265866	.	50125	0.12
chr19_41857694_41857871	0.06	TMEM91	transmembrane protein 91	966	0.33
chr5_10401090_10401251	0.06	MARCH6	membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase	799	0.58
chr8_20400144_20400295	0.06	ENSG00000251944	.	72218	0.13
chr13_44999768_45000008	0.06	TSC22D1	TSC22 domain family, member 1	11093	0.27
chr6_7202982_7203133	0.06	ENSG00000201483	.	15138	0.18
chr10_82181954_82182105	0.06	FAM213A	family with sequence similarity 213, member A	2275	0.31
chr15_89973751_89973944	0.06	RHCG	Rh family, C glycoprotein	48814	0.11
chr12_70222735_70222886	0.06	MYRFL	myelin regulatory factor-like	3714	0.27
chr3_169028756_169028966	0.06	MECOM	MDS1 and EVI1 complex locus	41835	0.2
chr22_45095245_45095396	0.05	PRR5	proline rich 5 (renal)	2758	0.23
chr4_118904844_118905063	0.05	NDST3	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3	50547	0.19
chr1_61870079_61870321	0.05	NFIA	nuclear factor I/A	452	0.9
chr1_160681135_160681490	0.05	CD48	CD48 molecule	281	0.89
chr16_85596439_85597190	0.05	GSE1	Gse1 coiled-coil protein	48201	0.14
chr11_9182138_9182467	0.05	DENND5A	DENN/MADD domain containing 5A	8348	0.2
chr1_226234793_226235057	0.05	H3F3A	H3 histone, family 3A	14627	0.16
chr3_64672491_64672773	0.05	ADAMTS9	ADAM metallopeptidase with thrombospondin type 1 motif, 9	723	0.66
chr8_67344451_67344602	0.05	ADHFE1	alcohol dehydrogenase, iron containing, 1	192	0.94
chr1_159870702_159871247	0.05	CCDC19	coiled-coil domain containing 19	1021	0.28
chr12_94503240_94503391	0.05	PLXNC1	plexin C1	39184	0.17
chr1_207244763_207244987	0.05	PFKFB2	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2	6526	0.14
chr2_74277135_74277286	0.05	TET3	tet methylcytosine dioxygenase 3	3760	0.22
chr1_64091668_64091877	0.05	PGM1	phosphoglucomutase 1	3008	0.26
chr5_159107_159571	0.05	ENSG00000199540	.	15027	0.14
chr5_75671808_75671959	0.05	IQGAP2	IQ motif containing GTPase activating protein 2	27191	0.22
chr12_122418604_122418840	0.05	BCL7A	B-cell CLL/lymphoma 7A	38606	0.14
chr2_129396287_129396587	0.05	ENSG00000238379	.	193665	0.03
chr3_52534556_52534707	0.05	STAB1	stabilin 1	5277	0.12
chr3_120154150_120154396	0.05	FSTL1	follistatin-like 1	15565	0.24
chr1_224518195_224518346	0.05	NVL	nuclear VCP-like	181	0.93
chr19_51642798_51642949	0.05	SIGLEC7	sialic acid binding Ig-like lectin 7	2683	0.13
chr9_8718709_8718860	0.05	PTPRD	protein tyrosine phosphatase, receptor type, D	15110	0.22
chr3_151066989_151067140	0.05	P2RY13	purinergic receptor P2Y, G-protein coupled, 13	19728	0.16
chr10_114612004_114612375	0.05	RP11-57H14.4		28940	0.19
chr1_230294761_230294912	0.05	GALNT2	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 (GalNAc-T2)	91818	0.08
chr11_303734_303885	0.05	IFITM2	interferon induced transmembrane protein 2	3822	0.08
chr13_27556748_27557003	0.05	USP12-AS1	USP12 antisense RNA 1	180117	0.03
chr18_24294487_24294638	0.05	ENSG00000265369	.	25069	0.2
chr13_51905768_51905919	0.05	SERPINE3	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 3	4066	0.18
chr7_2775422_2775573	0.05	GNA12	guanine nucleotide binding protein (G protein) alpha 12	27277	0.18
chr15_82232869_82233020	0.05	ENSG00000222521	.	103691	0.07
chr7_102552878_102553029	0.05	LRRC17	leucine rich repeat containing 17	485	0.81
chr3_16127076_16127227	0.05	GALNT15	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 15	89005	0.09
chr2_109275037_109275317	0.05	LIMS1	LIM and senescent cell antigen-like domains 1	3668	0.26
chr12_109248280_109248431	0.05	SSH1	slingshot protein phosphatase 1	3004	0.2
chr2_29769435_29769586	0.05	ENSG00000266310	.	42651	0.2
chr13_32691092_32691282	0.05	FRY	furry homolog (Drosophila)	56186	0.14
chr9_129094506_129094657	0.05	MVB12B	multivesicular body subunit 12B	2917	0.35
chr20_40138790_40139006	0.04	CHD6	chromodomain helicase DNA binding protein 6	10941	0.28
chr2_60640689_60640976	0.04	ENSG00000266078	.	26252	0.19
chr12_106695790_106695941	0.04	TCP11L2	t-complex 11, testis-specific-like 2	158	0.94
chrX_30671018_30671169	0.04	GK	glycerol kinase	383	0.86
chr3_193857613_193857764	0.04	HES1	hes family bHLH transcription factor 1	3754	0.23
chr3_138581340_138581807	0.04	PIK3CB	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta	27793	0.2
chr3_186790709_186790860	0.04	ST6GAL1	ST6 beta-galactosamide alpha-2,6-sialyltranferase 1	29253	0.19
chr22_23933989_23934140	0.04	IGLL1	immunoglobulin lambda-like polypeptide 1	11569	0.15
chr12_107486536_107486701	0.04	RP11-797M17.1		458	0.71
chr19_52006625_52006805	0.04	SIGLEC12	sialic acid binding Ig-like lectin 12 (gene/pseudogene)	1672	0.22
chr10_35640492_35640744	0.04	CCNY	cyclin Y	14816	0.2
chr5_81144030_81144509	0.04	SSBP2	single-stranded DNA binding protein 2	97197	0.08
chr15_57441064_57441218	0.04	TCF12	transcription factor 12	70487	0.12
chr4_57980142_57980293	0.04	IGFBP7	insulin-like growth factor binding protein 7	3666	0.21
chr6_43968341_43968530	0.04	C6orf223	chromosome 6 open reading frame 223	81	0.97
chr13_108102387_108102666	0.04	ENSG00000221650	.	81070	0.11
chr8_61245272_61245534	0.04	CA8	carbonic anhydrase VIII	51432	0.18
chr8_62672510_62672919	0.04	ENSG00000264408	.	45367	0.17
chr3_119265682_119265833	0.04	CD80	CD80 molecule	10818	0.15
chr9_125810997_125811288	0.04	GPR21	G protein-coupled receptor 21	14336	0.17
chr2_124782496_124782647	0.04	AC079154.1		179	0.65
chr11_62165677_62166025	0.04	CTD-2531D15.5		5007	0.13
chr18_10059619_10060204	0.04	ENSG00000263630	.	54717	0.15
chr1_183573322_183573539	0.04	NCF2	neutrophil cytosolic factor 2	13419	0.17
chr4_11100801_11100971	0.04	ENSG00000207716	.	269565	0.02
chr5_172266910_172267216	0.04	ERGIC1	endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1	5649	0.2
chr17_40109541_40109731	0.04	CNP	2',3'-cyclic nucleotide 3' phosphodiesterase	9123	0.12
chr2_37016528_37016679	0.04	VIT	vitrin	15648	0.22
chr3_46263444_46263746	0.04	CCR1	chemokine (C-C motif) receptor 1	13708	0.2
chr3_133710084_133710385	0.04	SLCO2A1	solute carrier organic anion transporter family, member 2A1	38524	0.17
chr9_7081128_7081335	0.04	KDM4C	lysine (K)-specific demethylase 4C	67443	0.14
chr10_72500668_72500819	0.04	TBATA	thymus, brain and testes associated	41645	0.15
chr5_160145_160296	0.04	ENSG00000199540	.	15908	0.14
chr1_246349977_246350128	0.04	ENSG00000202184	.	2368	0.32
chr8_108510907_108511284	0.04	ANGPT1	angiopoietin 1	812	0.78
chr4_8274597_8274776	0.04	HTRA3	HtrA serine peptidase 3	3182	0.29
chr14_85786368_85786640	0.04	ENSG00000252529	.	48228	0.2
chr1_201501281_201501432	0.04	CSRP1	cysteine and glycine-rich protein 1	22772	0.15
chr20_33291227_33291378	0.04	TP53INP2	tumor protein p53 inducible nuclear protein 2	792	0.67
chr11_9731889_9732040	0.04	SWAP70	SWAP switching B-cell complex 70kDa subunit	9649	0.18
chr1_223351560_223351778	0.04	TLR5	toll-like receptor 5	35045	0.22
chr17_45020470_45020621	0.04	GOSR2	golgi SNAP receptor complex member 2	4580	0.17
chr4_176922781_176923153	0.04	GPM6A	glycoprotein M6A	516	0.83
chr2_8678901_8679157	0.04	AC011747.7		136867	0.05
chr2_122465053_122465293	0.04	ENSG00000238341	.	1540	0.37
chr6_21832322_21832575	0.04	SOX4	SRY (sex determining region Y)-box 4	238377	0.02
chr2_48475922_48476221	0.04	ENSG00000201010	.	31357	0.2
chr6_34865245_34865499	0.04	ANKS1A	ankyrin repeat and sterile alpha motif domain containing 1A	8292	0.2
chr1_111098007_111098158	0.04	KCNA10	potassium voltage-gated channel, shaker-related subfamily, member 10	36285	0.13
chr1_10125719_10125870	0.04	UBE4B	ubiquitination factor E4B	32140	0.14
chr2_152191078_152191290	0.04	TNFAIP6	tumor necrosis factor, alpha-induced protein 6	22922	0.15
chr3_124378361_124378512	0.04	KALRN	kalirin, RhoGEF kinase	17751	0.18
chr15_79615080_79615231	0.04	TMED3	transmembrane emp24 protein transport domain containing 3	11657	0.19
chr2_74994703_74994854	0.04	HK2	hexokinase 2	66330	0.1
chr9_133769634_133769785	0.04	QRFP	pyroglutamylated RFamide peptide	484	0.8
chr1_192139874_192140185	0.04	RGS18	regulator of G-protein signaling 18	12442	0.31
chr3_194973552_194973874	0.04	XXYLT1	xyloside xylosyltransferase 1	5064	0.19
chr2_220325041_220325196	0.04	SPEG	SPEG complex locus	370	0.75
chr12_3861332_3861486	0.04	EFCAB4B	EF-hand calcium binding domain 4B	854	0.68
chr1_150337439_150337590	0.04	RPRD2	regulation of nuclear pre-mRNA domain containing 2	327	0.86
chr18_12596233_12596512	0.04	SPIRE1	spire-type actin nucleation factor 1	56712	0.09
chr12_96388567_96388718	0.04	HAL	histidine ammonia-lyase	336	0.81
chr9_80997377_80997562	0.04	PSAT1	phosphoserine aminotransferase 1	85410	0.1
chr17_76238005_76238295	0.04	TMEM235	transmembrane protein 235	10028	0.13
chr21_46530039_46530452	0.04	PRED58		4628	0.17
chr8_37773430_37773841	0.04	ENSG00000241032	.	7376	0.14
chr1_199151279_199151430	0.04	ENSG00000239006	.	14958	0.31
chr11_19221194_19221345	0.04	CSRP3	cysteine and glycine-rich protein 3 (cardiac LIM protein)	2320	0.27
chr22_30753251_30753448	0.04	CCDC157	coiled-coil domain containing 157	353	0.48
chr1_66859382_66859614	0.04	PDE4B	phosphodiesterase 4B, cAMP-specific	39433	0.21
chr1_221271721_221272131	0.04	HLX	H2.0-like homeobox	217342	0.02
chr12_76937660_76937890	0.04	OSBPL8	oxysterol binding protein-like 8	15509	0.29
chr16_72870979_72871130	0.04	ENSG00000251868	.	15163	0.18
chr12_124252156_124252428	0.04	DNAH10	dynein, axonemal, heavy chain 10	5250	0.19
chr1_201526153_201526357	0.04	CSRP1	cysteine and glycine-rich protein 1	47671	0.1
chr12_4000260_4000425	0.04	RP11-664D1.1		7877	0.24
chr5_122227048_122227199	0.04	SNX24	sorting nexin 24	45802	0.13
chr18_74333332_74333853	0.04	LINC00908	long intergenic non-protein coding RNA 908	92718	0.08
chr13_107571963_107572200	0.04	ENSG00000239050	.	55293	0.17
chr1_229165049_229165220	0.04	RP5-1061H20.5		198175	0.02
chr1_90377108_90377305	0.04	LRRC8D	leucine rich repeat containing 8 family, member D	65067	0.11
chr3_190252277_190252428	0.03	IL1RAP	interleukin 1 receptor accessory protein	20461	0.24
chr6_89855370_89855671	0.03	PM20D2	peptidase M20 domain containing 2	249	0.91
chr6_86388179_86388330	0.03	ENSG00000203875	.	878	0.62
chr11_131928609_131928889	0.03	RP11-697E14.2		74194	0.12
chr20_2260711_2261046	0.03	TGM3	transglutaminase 3	15769	0.23
chr3_179182596_179182747	0.03	GNB4	guanine nucleotide binding protein (G protein), beta polypeptide 4	13293	0.18
chr9_140162312_140162640	0.03	TOR4A	torsin family 4, member A	9725	0.07
chr1_201523227_201523378	0.03	CSRP1	cysteine and glycine-rich protein 1	44718	0.11
chr18_47813563_47813872	0.03	CXXC1	CXXC finger protein 1	223	0.92
chr12_20557465_20557616	0.03	RP11-284H19.1		34344	0.2
chr2_47500188_47500420	0.03	EPCAM	epithelial cell adhesion molecule	71993	0.09
chr5_167248531_167248682	0.03	ENSG00000221741	.	49064	0.14
chr1_28919373_28919559	0.03	RAB42	RAB42, member RAS oncogene family	754	0.51
chr19_51231309_51231608	0.03	CLEC11A	C-type lectin domain family 11, member A	4678	0.12
chr19_41329835_41330195	0.03	EGLN2	egl-9 family hypoxia-inducible factor 2	16867	0.11
chr1_204158879_204159072	0.03	KISS1	KiSS-1 metastasis-suppressor	6639	0.15
chr3_148585148_148585299	0.03	CPA3	carboxypeptidase A3 (mast cell)	2180	0.36
chr8_13115208_13115359	0.03	DLC1	deleted in liver cancer 1	18772	0.25
chr11_11610992_11611143	0.03	RP11-483L5.1		19436	0.21
chr7_6474403_6474587	0.03	DAGLB	diacylglycerol lipase, beta	13068	0.16
chr5_54867827_54868108	0.03	PPAP2A	phosphatidic acid phosphatase type 2A	37089	0.17
chr10_111751358_111751641	0.03	ENSG00000263706	.	12513	0.18
chr2_173139735_173139887	0.03	ENSG00000238572	.	118963	0.05
chr2_43233940_43234091	0.03	ENSG00000207087	.	84617	0.1
chr11_103774710_103774942	0.03	RP11-617B3.2		41450	0.18
chr10_131681520_131681924	0.03	ENSG00000266676	.	40084	0.18
chr14_39335871_39336022	0.03	ENSG00000199285	.	120539	0.06
chr4_139156204_139156442	0.03	SLC7A11	solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11	7180	0.31
chr2_232571942_232572093	0.03	PTMA	prothymosin, alpha	377	0.48
chr6_146285006_146285157	0.03	SHPRH	SNF2 histone linker PHD RING helicase, E3 ubiquitin protein ligase	152	0.97
chr19_12809158_12809309	0.03	FBXW9	F-box and WD repeat domain containing 9	1776	0.14
chr11_78021684_78021846	0.03	RP11-452H21.1		14039	0.18
chr8_107299673_107299824	0.03	OXR1	oxidation resistance 1	17275	0.3
chr10_114747236_114747430	0.03	RP11-57H14.2		35699	0.18
chr2_27110278_27110603	0.03	DPYSL5	dihydropyrimidinase-like 5	39064	0.12
chr15_58160193_58160344	0.03	ALDH1A2	aldehyde dehydrogenase 1 family, member A2	146031	0.04
chr6_27143884_27144131	0.03	ENSG00000265565	.	28602	0.1
chr16_12096454_12096617	0.03	RP11-166B2.7		24828	0.11
chr1_45940556_45940894	0.03	TESK2	testis-specific kinase 2	16090	0.14
chr1_95007732_95008585	0.03	F3	coagulation factor III (thromboplastin, tissue factor)	802	0.76
chr20_35903692_35903888	0.03	GHRH	growth hormone releasing hormone	13552	0.18
chr7_40337996_40338297	0.03	SUGCT	succinylCoA:glutarate-CoA transferase	163527	0.04
chr14_93651677_93652183	0.03	TMEM251	transmembrane protein 251	572	0.33
chr19_51748907_51749058	0.03	SIGLECL1	SIGLEC family like 1	621	0.55
chr7_129710940_129711854	0.03	KLHDC10	kelch domain containing 10	785	0.58
chr11_120822754_120822905	0.03	RP11-640N11.2		57323	0.15
chr9_73170403_73170554	0.03	ENSG00000272232	.	23899	0.25
chr2_105593697_105593939	0.03	ENSG00000263685	.	15620	0.19
chr14_74981270_74981555	0.03	LTBP2	latent transforming growth factor beta binding protein 2	4902	0.17
chr5_34864010_34864161	0.03	CTD-2517O10.6		24702	0.15
chr22_35767629_35767792	0.03	HMOX1	heme oxygenase (decycling) 1	8644	0.18
chr14_35874255_35874406	0.03	NFKBIA	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	378	0.91
chr2_114132740_114132924	0.03	IGKV1OR2-108	immunoglobulin kappa variable 1/OR2-108 (non-functional)	31141	0.14
chr14_62063396_62063547	0.03	RP11-47I22.3	Uncharacterized protein	26157	0.19
chr13_21593056_21593207	0.03	LATS2-AS1	LATS2 antisense RNA 1	13835	0.14

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of RBPJ

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View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.0	GO:0030210	heparin biosynthetic process(GO:0030210)
0.0	0.0	GO:0019276	UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.0	0.0	GO:0070427	nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427)
0.0	0.0	GO:0045198	establishment of epithelial cell apical/basal polarity(GO:0045198)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.0	GO:0004370	glycerol kinase activity(GO:0004370)