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ENCODE: H3K4me1 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for RELA

Z-value: 1.25

Motif logo

Transcription factors associated with RELA

Gene Symbol	Gene ID	Gene Info
RELA Ensembl NCBI GeneCards UniProt	ENSG00000173039.14	RELA

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
RELA	chr11_65429605_65429909	142	0.903658	-0.79	1.2e-02	Click!
RELA	chr11_65428971_65429545	641	0.500183	-0.67	5.0e-02	Click!
RELA	chr11_65430900_65431059	414	0.682070	-0.59	9.4e-02	Click!
RELA	chr11_65431282_65431834	993	0.326887	-0.47	2.0e-01	Click!
RELA	chr11_65424945_65425096	2194	0.142375	-0.28	4.6e-01	Click!

Activity of the RELA motif across conditions

Conditions sorted by the z-value of the RELA motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr19_13120371_13120965	0.88	NFIX	nuclear factor I/X (CCAAT-binding transcription factor)	2334	0.15
chr5_14055268_14055419	0.68	TRIO	trio Rho guanine nucleotide exchange factor	88468	0.1
chr2_64431477_64431968	0.66	AC074289.1		2387	0.38
chr14_25518403_25519489	0.61	STXBP6	syntaxin binding protein 6 (amisyn)	149	0.98
chr1_111735380_111736106	0.59	DENND2D	DENN/MADD domain containing 2D	7568	0.12
chr10_134224918_134226015	0.57	PWWP2B	PWWP domain containing 2B	14764	0.17
chr1_16479115_16479478	0.57	RP11-276H7.2		2410	0.18
chr14_69014642_69014793	0.54	CTD-2325P2.4		80445	0.1
chr10_112288804_112288973	0.53	DUSP5	dual specificity phosphatase 5	31292	0.13
chr12_28019839_28019990	0.53	ENSG00000201612	.	60591	0.09
chr4_24227998_24228149	0.51	ENSG00000222262	.	194851	0.03
chr7_28077677_28077828	0.50	JAZF1	JAZF zinc finger 1	17334	0.25
chr5_131599252_131599414	0.50	PDLIM4	PDZ and LIM domain 4	2191	0.26
chr10_60617108_60617259	0.50	ENSG00000252076	.	11761	0.28
chr21_36217039_36217945	0.49	RUNX1	runt-related transcription factor 1	41988	0.19
chr12_398019_398170	0.49	RP11-283I3.6		11805	0.15
chr4_37695342_37695493	0.49	ENSG00000207075	.	6207	0.23
chr19_42626039_42626662	0.49	POU2F2	POU class 2 homeobox 2	382	0.74
chr20_62330262_62330413	0.48	TNFRSF6B	tumor necrosis factor receptor superfamily, member 6b, decoy	2316	0.13
chr5_142563019_142563312	0.46	ARHGAP26-IT1	ARHGAP26 intronic transcript 1 (non-protein coding)	8900	0.26
chr9_136738727_136738896	0.46	VAV2	vav 2 guanine nucleotide exchange factor	118592	0.05
chr8_94918337_94918663	0.46	ENSG00000264448	.	9847	0.19
chr1_246754834_246755065	0.46	RP11-439E19.1		14226	0.17
chr2_19132169_19132320	0.45	NT5C1B	5'-nucleotidase, cytosolic IB	361406	0.01
chr7_5971680_5971831	0.44	RSPH10B	radial spoke head 10 homolog B (Chlamydomonas)	26959	0.11
chr5_140901959_140902110	0.44	DIAPH1	diaphanous-related formin 1	3680	0.13
chr1_155436245_155436396	0.44	ENSG00000207144	.	47132	0.09
chr1_215361477_215361628	0.44	KCNK2	potassium channel, subfamily K, member 2	104692	0.08
chr1_19774465_19775000	0.44	ENSG00000240490	.	23854	0.14
chr15_85473411_85473562	0.43	ENSG00000207037	.	8267	0.16
chr1_235123444_235123890	0.43	ENSG00000239690	.	83734	0.09
chr2_145116564_145116715	0.42	GTDC1	glycosyltransferase-like domain containing 1	26556	0.24
chr17_75251839_75251990	0.42	SEPT9	septin 9	24737	0.19
chr9_114791054_114791349	0.42	RP11-4O1.2		7389	0.21
chr3_62598104_62598255	0.42	CADPS	Ca++-dependent secretion activator	27258	0.26
chr6_166980327_166980478	0.41	RPS6KA2	ribosomal protein S6 kinase, 90kDa, polypeptide 2	22224	0.19
chr2_122121105_122121256	0.41	CLASP1	cytoplasmic linker associated protein 1	63866	0.13
chr7_110753696_110753847	0.41	ENSG00000238922	.	4358	0.29
chr22_30646914_30647065	0.41	LIF	leukemia inhibitory factor	4149	0.12
chr1_52024489_52024927	0.41	OSBPL9	oxysterol binding protein-like 9	18143	0.15
chr1_14847140_14847291	0.40	KAZN	kazrin, periplakin interacting protein	77985	0.12
chr4_57945701_57945852	0.40	ENSG00000238541	.	26735	0.14
chr6_135229867_135230018	0.40	ALDH8A1	aldehyde dehydrogenase 8 family, member A1	20357	0.21
chr2_112153168_112153719	0.40	ENSG00000266139	.	74775	0.13
chr10_80916996_80917718	0.40	ZMIZ1	zinc finger, MIZ-type containing 1	88565	0.09
chr14_77370831_77371251	0.39	ENSG00000223174	.	14435	0.2
chr6_54057923_54058074	0.39	MLIP	muscular LMNA-interacting protein	81690	0.1
chr2_219757049_219757365	0.39	WNT10A	wingless-type MMTV integration site family, member 10A	10324	0.11
chr22_32447005_32447156	0.39	SLC5A1	solute carrier family 5 (sodium/glucose cotransporter), member 1	8061	0.19
chr13_110780415_110780566	0.39	ENSG00000265885	.	29992	0.24
chr12_48124290_48124441	0.39	ENDOU	endonuclease, polyU-specific	5015	0.17
chr9_117110893_117111174	0.38	AKNA	AT-hook transcription factor	189	0.95
chr1_33761314_33761465	0.38	RP11-415J8.3		11578	0.13
chr1_16508178_16508413	0.38	ARHGEF19-AS1	ARHGEF19 antisense RNA 1	16054	0.1
chr19_50289714_50289865	0.38	AP2A1	adaptor-related protein complex 2, alpha 1 subunit	19398	0.06
chr6_37521261_37521499	0.38	ENSG00000263926	.	1818	0.41
chr17_79949976_79950203	0.37	ASPSCR1	alveolar soft part sarcoma chromosome region, candidate 1	3230	0.09
chr3_126721307_126721580	0.37	PLXNA1	plexin A1	14006	0.29
chr2_204468904_204469055	0.37	RAPH1	Ras association (RalGDS/AF-6) and pleckstrin homology domains 1	68846	0.12
chr7_151387438_151387589	0.36	PRKAG2	protein kinase, AMP-activated, gamma 2 non-catalytic subunit	45836	0.15
chr2_218576039_218576190	0.36	DIRC3	disrupted in renal carcinoma 3	45164	0.19
chr7_73983441_73983592	0.36	ENSG00000252378	.	2161	0.33
chr9_136821628_136822276	0.36	VAV2	vav 2 guanine nucleotide exchange factor	35451	0.17
chr5_88579017_88579168	0.35	MEF2C-AS1	MEF2C antisense RNA 1	135532	0.06
chr8_124529392_124529769	0.35	FBXO32	F-box protein 32	23866	0.18
chr2_113735290_113735441	0.35	IL36G	interleukin 36, gamma	231	0.92
chr2_235578887_235579038	0.34	ARL4C	ADP-ribosylation factor-like 4C	173265	0.04
chr21_43459806_43459957	0.34	UMODL1	uromodulin-like 1	23187	0.16
chr8_19869720_19869871	0.34	AC100802.3		67021	0.12
chr4_106108196_106108347	0.34	TET2-AS1	TET2 antisense RNA 1	9051	0.24
chr5_81459991_81460142	0.34	ENSG00000265684	.	85820	0.08
chr12_28119783_28119934	0.34	PTHLH	parathyroid hormone-like hormone	2569	0.31
chr1_230249285_230249570	0.33	GALNT2	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 (GalNAc-T2)	46409	0.16
chr22_36720442_36720593	0.33	ENSG00000266345	.	8271	0.19
chr1_25691144_25691295	0.33	ENSG00000238889	.	18351	0.11
chr8_43046499_43046650	0.33	HGSNAT	heparan-alpha-glucosaminide N-acetyltransferase	11142	0.22
chr20_32922542_32922693	0.33	AHCY	adenosylhomocysteinase	23009	0.13
chr7_492646_493023	0.33	PDGFA	platelet-derived growth factor alpha polypeptide	65311	0.11
chr7_31988455_31988606	0.32	PDE1C	phosphodiesterase 1C, calmodulin-dependent 70kDa	121931	0.06
chr5_17186685_17186836	0.32	ENSG00000251990	.	29580	0.14
chr6_9521428_9521579	0.32	OFCC1	orofacial cleft 1 candidate 1	411997	0.01
chr1_23801357_23801508	0.32	ASAP3	ArfGAP with SH3 domain, ankyrin repeat and PH domain 3	9239	0.18
chr18_33889238_33889389	0.32	FHOD3	formin homology 2 domain containing 3	11514	0.27
chr14_77773550_77773731	0.32	POMT2	protein-O-mannosyltransferase 2	13043	0.12
chr1_39758697_39758848	0.32	MACF1	microtubule-actin crosslinking factor 1	7214	0.22
chr1_37945557_37946349	0.32	ZC3H12A	zinc finger CCCH-type containing 12A	1338	0.36
chr16_86964951_86965102	0.31	RP11-899L11.3		284495	0.01
chr7_5733225_5733376	0.31	RNF216-IT1	RNF216 intronic transcript 1 (non-protein coding)	13208	0.2
chr16_67346089_67346240	0.31	KCTD19	potassium channel tetramerization domain containing 19	9649	0.09
chr5_71698297_71698448	0.31	RP11-389C8.2		39842	0.16
chr8_122835118_122835355	0.31	HAS2-AS1	HAS2 antisense RNA 1	181560	0.03
chr20_13211744_13212262	0.31	ISM1-AS1	ISM1 antisense RNA 1	8318	0.2
chr10_124136204_124136523	0.31	PLEKHA1	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1	2013	0.32
chr7_17412244_17412395	0.31	ENSG00000199473	.	631	0.81
chr11_114217659_114217947	0.31	RP11-64D24.2		9490	0.18
chr22_51020006_51020440	0.31	CHKB	choline kinase beta	1205	0.2
chr9_117826218_117826369	0.31	TNC	tenascin C	898	0.71
chr19_39176650_39177321	0.31	CTB-186G2.4		7261	0.12
chr19_46080635_46080786	0.31	OPA3	optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)	7367	0.12
chr17_38336562_38336713	0.31	RAPGEFL1	Rap guanine nucleotide exchange factor (GEF)-like 1	854	0.5
chr16_68321146_68321898	0.31	ENSG00000252026	.	3301	0.1
chr2_102081509_102081660	0.30	RFX8	RFX family member 8, lacking RFX DNA binding domain	9153	0.27
chr8_128821695_128821987	0.30	ENSG00000249859	.	13633	0.26
chr1_201992311_201992462	0.30	RP11-510N19.5		11888	0.11
chr6_45559057_45559277	0.30	ENSG00000252738	.	54674	0.17
chr3_137762283_137762711	0.30	DZIP1L	DAZ interacting zinc finger protein 1-like	23985	0.17
chr10_126723650_126723801	0.30	ENSG00000264572	.	2286	0.32
chr11_119438556_119438707	0.30	RP11-196E1.3		40504	0.15
chr10_128109942_128110093	0.30	ADAM12	ADAM metallopeptidase domain 12	32993	0.19
chr8_32126966_32127117	0.30	ENSG00000200246	.	13029	0.24
chr11_118786204_118786601	0.30	BCL9L	B-cell CLL/lymphoma 9-like	3211	0.11
chr5_5340745_5341045	0.30	KIAA0947	KIAA0947	81912	0.11
chr11_102470906_102471057	0.30	RP11-817J15.2		6666	0.19
chr10_33320919_33321292	0.30	ENSG00000265319	.	2747	0.32
chr5_52630256_52630554	0.29	FST	follistatin	145834	0.04
chr11_118782916_118784128	0.29	BCL9L	B-cell CLL/lymphoma 9-like	1909	0.16
chr1_201265444_201265595	0.29	PKP1	plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)	12688	0.19
chr2_87854693_87854844	0.29	ENSG00000265507	.	74506	0.11
chr5_54054265_54054416	0.29	ENSG00000221073	.	94436	0.08
chr7_74002155_74002306	0.29	ENSG00000252378	.	16553	0.2
chr2_120009918_120010346	0.29	STEAP3-AS1	STEAP3 antisense RNA 1	3485	0.25
chr13_44806372_44806666	0.29	SMIM2	small integral membrane protein 2	71126	0.11
chr7_92427069_92427220	0.29	CDK6	cyclin-dependent kinase 6	36087	0.17
chr15_89455158_89455741	0.29	MFGE8	milk fat globule-EGF factor 8 protein	1144	0.49
chr1_228268932_228269720	0.29	ARF1	ADP-ribosylation factor 1	1035	0.41
chr21_30464772_30464923	0.29	MAP3K7CL	MAP3K7 C-terminal like	272	0.88
chr17_79302865_79303213	0.29	TMEM105	transmembrane protein 105	1176	0.39
chr1_6419428_6419896	0.29	ACOT7	acyl-CoA thioesterase 7	258	0.9
chr10_29910095_29910342	0.29	SVIL	supervillin	13683	0.19
chr9_91144416_91144843	0.28	NXNL2	nucleoredoxin-like 2	5387	0.32
chr12_11908349_11908500	0.28	ETV6	ets variant 6	2989	0.38
chr17_38263559_38264452	0.28	NR1D1	nuclear receptor subfamily 1, group D, member 1	7027	0.12
chr19_47730648_47731306	0.28	ENSG00000265134	.	778	0.55
chr19_1546180_1546480	0.28	ENSG00000266399	.	7701	0.08
chr11_111392089_111392240	0.28	RP11-794P6.6		5316	0.11
chr2_235890567_235890856	0.27	SH3BP4	SH3-domain binding protein 4	443	0.91
chr5_177370096_177370366	0.27	RP11-1252I4.2		3608	0.18
chr3_114379229_114379380	0.27	ZBTB20	zinc finger and BTB domain containing 20	35512	0.22
chr13_106807816_106807967	0.27	ENSG00000222682	.	52	0.98
chr17_1686320_1687263	0.27	SERPINF1	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1	11778	0.11
chr2_221141967_221142118	0.27	ENSG00000221199	.	85443	0.1
chr4_108611767_108611918	0.27	PAPSS1	3'-phosphoadenosine 5'-phosphosulfate synthase 1	29766	0.23
chr11_35205869_35206020	0.27	CD44	CD44 molecule (Indian blood group)	2446	0.25
chr1_110470801_110470952	0.27	CSF1	colony stimulating factor 1 (macrophage)	17268	0.16
chr22_36406894_36407045	0.27	RBFOX2	RNA binding protein, fox-1 homolog (C. elegans) 2	17504	0.26
chr10_3930051_3930202	0.27	KLF6	Kruppel-like factor 6	102653	0.08
chr8_67424665_67424816	0.27	ENSG00000206949	.	11194	0.19
chr2_100422888_100423180	0.27	AFF3	AF4/FMR2 family, member 3	228202	0.02
chr9_114792336_114792610	0.27	RP11-4O1.2		6117	0.22
chr2_196440572_196441282	0.27	SLC39A10	solute carrier family 39 (zinc transporter), member 10	226	0.96
chr10_6243827_6244661	0.26	RP11-414H17.5		412	0.58
chr11_34255458_34256011	0.26	ENSG00000201867	.	45013	0.17
chr10_124220042_124220595	0.26	HTRA1	HtrA serine peptidase 1	723	0.66
chr16_72290694_72290845	0.26	PMFBP1	polyamine modulated factor 1 binding protein 1	79992	0.09
chr10_104408471_104409659	0.26	TRIM8	tripartite motif containing 8	4421	0.2
chr12_127610439_127610590	0.26	ENSG00000239776	.	40158	0.23
chr12_11975182_11975534	0.26	ETV6	ets variant 6	63513	0.14
chr4_157720350_157720504	0.26	RP11-154F14.2		42084	0.17
chr17_16311388_16311661	0.26	TRPV2	transient receptor potential cation channel, subfamily V, member 2	7332	0.13
chr16_89690125_89690276	0.26	DPEP1	dipeptidase 1 (renal)	3200	0.14
chr17_70123100_70123251	0.26	SOX9	SRY (sex determining region Y)-box 9	6014	0.33
chr1_59479041_59479192	0.26	JUN	jun proto-oncogene	229331	0.02
chr3_11507209_11507360	0.26	ATG7	autophagy related 7	101151	0.07
chr6_12025532_12025683	0.26	HIVEP1	human immunodeficiency virus type I enhancer binding protein 1	9787	0.26
chr7_101812750_101813040	0.26	ENSG00000252824	.	24549	0.18
chr20_32404981_32405132	0.26	CHMP4B	charged multivesicular body protein 4B	5946	0.18
chr6_41513317_41513955	0.26	RP11-328M4.2		176	0.81
chr16_88831505_88831885	0.26	PIEZO1	piezo-type mechanosensitive ion channel component 1	19924	0.07
chr16_8954168_8954319	0.25	CARHSP1	calcium regulated heat stable protein 1, 24kDa	1327	0.31
chr2_151377864_151378015	0.25	RND3	Rho family GTPase 3	17586	0.31
chr18_9416638_9416789	0.25	RALBP1	ralA binding protein 1	58294	0.1
chr2_38265057_38265550	0.25	RMDN2-AS1	RMDN2 antisense RNA 1	1819	0.36
chr4_41202697_41202848	0.25	APBB2	amyloid beta (A4) precursor protein-binding, family B, member 2	13703	0.2
chr22_31502717_31502868	0.25	SELM	Selenoprotein M	762	0.5
chr19_10045992_10046143	0.25	OLFM2	olfactomedin 2	1161	0.4
chr4_68580052_68580203	0.25	UBA6-AS1	UBA6 antisense RNA 1 (head to head)	13014	0.17
chr1_167744512_167744663	0.25	MPZL1	myelin protein zero-like 1	9780	0.23
chr10_104562844_104563157	0.25	ENSG00000252994	.	686	0.6
chr19_14672759_14672910	0.25	TECR	trans-2,3-enoyl-CoA reductase	55	0.95
chr17_4401391_4401902	0.25	SPNS2	spinster homolog 2 (Drosophila)	487	0.65
chr11_35034999_35035461	0.25	PDHX	pyruvate dehydrogenase complex, component X	35899	0.17
chr1_210573481_210573755	0.24	ENSG00000200972	.	26007	0.21
chr5_178806268_178806419	0.24	ADAMTS2	ADAM metallopeptidase with thrombospondin type 1 motif, 2	33912	0.19
chr6_125425186_125425448	0.24	TPD52L1	tumor protein D52-like 1	14878	0.26
chr4_72159835_72159986	0.24	SLC4A4	solute carrier family 4 (sodium bicarbonate cotransporter), member 4	44860	0.2
chr8_101514645_101514908	0.24	KB-1615E4.3		10020	0.18
chr22_41686786_41686937	0.24	AL035681.1		1175	0.36
chr19_46283041_46283318	0.24	DMPK	dystrophia myotonica-protein kinase	620	0.48
chr4_143285799_143285950	0.24	INPP4B	inositol polyphosphate-4-phosphatase, type II, 105kDa	58777	0.17
chr5_77814160_77814311	0.24	LHFPL2	lipoma HMGIC fusion partner-like 2	30739	0.24
chr1_110435299_110435450	0.24	RP11-195M16.1		6488	0.19
chr4_74864472_74864623	0.24	CXCL5	chemokine (C-X-C motif) ligand 5	51	0.96
chr13_41092746_41092897	0.24	AL133318.1	Uncharacterized protein	18502	0.26
chr4_106816798_106817272	0.24	INTS12	integrator complex subunit 12	108	0.67
chr10_133794328_133795175	0.24	BNIP3	BCL2/adenovirus E1B 19kDa interacting protein 3	676	0.77
chr6_10735071_10735222	0.24	TMEM14C	transmembrane protein 14C	11938	0.12
chr15_40339457_40340106	0.24	SRP14	signal recognition particle 14kDa (homologous Alu RNA binding protein)	8392	0.16
chr14_23316976_23317711	0.24	ENSG00000212335	.	4594	0.09
chr1_156073569_156073968	0.24	LMNA	lamin A/C	10693	0.1
chr5_137566220_137566371	0.24	CDC23	cell division cycle 23	17263	0.12

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of RELA

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0060648	mammary gland bud morphogenesis(GO:0060648)
0.1	0.2	GO:0060426	lung vasculature development(GO:0060426)
0.0	0.1	GO:0006883	cellular sodium ion homeostasis(GO:0006883)
0.0	0.2	GO:0071364	cellular response to epidermal growth factor stimulus(GO:0071364)
0.0	0.1	GO:0019049	evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.0	0.1	GO:1902339	apoptotic process involved in mammary gland involution(GO:0060057) positive regulation of apoptotic process involved in mammary gland involution(GO:0060058) positive regulation of apoptotic process involved in morphogenesis(GO:1902339) regulation of mammary gland involution(GO:1903519) positive regulation of mammary gland involution(GO:1903521) positive regulation of apoptotic process involved in development(GO:1904747)
0.0	0.2	GO:0048096	chromatin-mediated maintenance of transcription(GO:0048096)
0.0	0.1	GO:0034201	response to oleic acid(GO:0034201)
0.0	0.1	GO:0070050	neuron cellular homeostasis(GO:0070050)
0.0	0.2	GO:0045662	negative regulation of myoblast differentiation(GO:0045662)
0.0	0.1	GO:0048319	axial mesoderm morphogenesis(GO:0048319)
0.0	0.1	GO:0045657	positive regulation of monocyte differentiation(GO:0045657)
0.0	0.1	GO:0072577	endothelial cell apoptotic process(GO:0072577) epithelial cell apoptotic process(GO:1904019) regulation of epithelial cell apoptotic process(GO:1904035) regulation of endothelial cell apoptotic process(GO:2000351)
0.0	0.0	GO:0060831	smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:0060831)
0.0	0.1	GO:0021797	forebrain anterior/posterior pattern specification(GO:0021797)
0.0	0.1	GO:0022007	neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007)
0.0	0.1	GO:0014819	regulation of skeletal muscle contraction(GO:0014819)
0.0	0.1	GO:0034139	regulation of toll-like receptor 3 signaling pathway(GO:0034139)
0.0	0.1	GO:0021631	optic nerve morphogenesis(GO:0021631)
0.0	0.1	GO:0010511	regulation of phosphatidylinositol biosynthetic process(GO:0010511)
0.0	0.2	GO:0060638	mesenchymal-epithelial cell signaling(GO:0060638)
0.0	0.1	GO:0021898	commitment of multipotent stem cells to neuronal lineage in forebrain(GO:0021898)
0.0	0.0	GO:0060449	bud elongation involved in lung branching(GO:0060449)
0.0	0.1	GO:0060453	regulation of gastric acid secretion(GO:0060453)
0.0	0.1	GO:0015820	branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820)
0.0	0.1	GO:0060666	dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.0	0.1	GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) 4-hydroxyproline metabolic process(GO:0019471) peptidyl-proline hydroxylation(GO:0019511)
0.0	0.1	GO:0042996	regulation of Golgi to plasma membrane protein transport(GO:0042996)
0.0	0.2	GO:0008634	obsolete negative regulation of survival gene product expression(GO:0008634)
0.0	0.1	GO:0007132	meiotic metaphase I(GO:0007132)
0.0	0.1	GO:0006391	transcription initiation from mitochondrial promoter(GO:0006391)
0.0	0.1	GO:0006295	nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295)
0.0	0.1	GO:0030579	ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0	0.1	GO:0034626	fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0	0.1	GO:0045542	positive regulation of cholesterol biosynthetic process(GO:0045542)
0.0	0.1	GO:0000103	sulfate assimilation(GO:0000103)
0.0	0.1	GO:0061318	renal filtration cell differentiation(GO:0061318) glomerular epithelium development(GO:0072010) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.0	0.0	GO:0072216	positive regulation of metanephros development(GO:0072216)
0.0	0.1	GO:0010716	regulation of extracellular matrix disassembly(GO:0010715) negative regulation of extracellular matrix disassembly(GO:0010716) regulation of extracellular matrix organization(GO:1903053) negative regulation of extracellular matrix organization(GO:1903054)
0.0	0.1	GO:0045830	positive regulation of isotype switching(GO:0045830)
0.0	0.1	GO:0001973	adenosine receptor signaling pathway(GO:0001973) G-protein coupled purinergic receptor signaling pathway(GO:0035588)
0.0	0.2	GO:0032456	endocytic recycling(GO:0032456)
0.0	0.0	GO:0060433	bronchus development(GO:0060433)
0.0	0.1	GO:0045350	interferon-beta biosynthetic process(GO:0045350) regulation of interferon-beta biosynthetic process(GO:0045357) positive regulation of interferon-beta biosynthetic process(GO:0045359)
0.0	0.1	GO:0006910	phagocytosis, recognition(GO:0006910)
0.0	0.2	GO:0033327	Leydig cell differentiation(GO:0033327)
0.0	0.0	GO:0048368	lateral mesoderm development(GO:0048368)
0.0	0.1	GO:0007000	nucleolus organization(GO:0007000)
0.0	0.1	GO:0018242	protein O-linked glycosylation via serine(GO:0018242) protein O-linked glycosylation via threonine(GO:0018243)
0.0	0.1	GO:0042574	retinal metabolic process(GO:0042574)
0.0	0.0	GO:0045835	negative regulation of meiotic nuclear division(GO:0045835)
0.0	0.0	GO:0060584	regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
0.0	0.1	GO:0009106	lipoate metabolic process(GO:0009106)
0.0	0.0	GO:0002513	tolerance induction to self antigen(GO:0002513)
0.0	0.1	GO:0036072	intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.0	0.1	GO:0032926	negative regulation of activin receptor signaling pathway(GO:0032926)
0.0	0.1	GO:0048200	COPI-coated vesicle budding(GO:0035964) Golgi vesicle budding(GO:0048194) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)
0.0	0.0	GO:0033173	calcineurin-NFAT signaling cascade(GO:0033173)
0.0	0.1	GO:0006032	chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.0	0.1	GO:0007520	myoblast fusion(GO:0007520)
0.0	0.1	GO:0007028	cytoplasm organization(GO:0007028)
0.0	0.0	GO:0060083	smooth muscle contraction involved in micturition(GO:0060083)
0.0	0.1	GO:0032958	inositol phosphate biosynthetic process(GO:0032958)
0.0	0.0	GO:0048289	isotype switching to IgE isotypes(GO:0048289) regulation of isotype switching to IgE isotypes(GO:0048293)
0.0	0.1	GO:0090218	positive regulation of lipid kinase activity(GO:0090218)
0.0	0.0	GO:0010761	fibroblast migration(GO:0010761)
0.0	0.1	GO:0045066	regulatory T cell differentiation(GO:0045066)
0.0	0.2	GO:0016180	snRNA processing(GO:0016180)
0.0	0.1	GO:0010799	regulation of peptidyl-threonine phosphorylation(GO:0010799)
0.0	0.0	GO:0090085	regulation of protein deubiquitination(GO:0090085)
0.0	0.0	GO:0033603	positive regulation of dopamine secretion(GO:0033603)
0.0	0.1	GO:0060314	regulation of ryanodine-sensitive calcium-release channel activity(GO:0060314)
0.0	0.1	GO:0000185	activation of MAPKKK activity(GO:0000185)
0.0	0.1	GO:0035413	positive regulation of catenin import into nucleus(GO:0035413)
0.0	0.0	GO:0032714	negative regulation of interleukin-5 production(GO:0032714)
0.0	0.1	GO:0032020	ISG15-protein conjugation(GO:0032020)
0.0	0.1	GO:0046952	ketone body catabolic process(GO:0046952)
0.0	0.1	GO:0070493	thrombin receptor signaling pathway(GO:0070493)
0.0	0.1	GO:0043985	histone H4-R3 methylation(GO:0043985)
0.0	0.1	GO:0006448	regulation of translational elongation(GO:0006448)
0.0	0.1	GO:0006003	fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0	0.0	GO:0048302	regulation of isotype switching to IgG isotypes(GO:0048302)
0.0	0.0	GO:0043578	nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0	0.0	GO:0060907	positive regulation of macrophage cytokine production(GO:0060907)
0.0	0.2	GO:0001516	prostaglandin biosynthetic process(GO:0001516) prostanoid biosynthetic process(GO:0046457)
0.0	0.1	GO:0032897	negative regulation of viral transcription(GO:0032897)
0.0	0.0	GO:0046476	glycosylceramide biosynthetic process(GO:0046476)
0.0	0.0	GO:0007343	egg activation(GO:0007343)
0.0	0.1	GO:1901797	negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518) negative regulation of signal transduction by p53 class mediator(GO:1901797)
0.0	0.1	GO:0070170	regulation of tooth mineralization(GO:0070170)
0.0	0.0	GO:0060528	secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.0	0.0	GO:0022417	protein maturation by protein folding(GO:0022417)
0.0	0.1	GO:0007185	transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0	0.0	GO:0010934	macrophage cytokine production(GO:0010934) regulation of macrophage cytokine production(GO:0010935)
0.0	0.0	GO:0010837	regulation of keratinocyte proliferation(GO:0010837)
0.0	0.0	GO:0048861	leukemia inhibitory factor signaling pathway(GO:0048861)
0.0	0.1	GO:0045907	positive regulation of vasoconstriction(GO:0045907)
0.0	0.1	GO:0006553	lysine metabolic process(GO:0006553) lysine catabolic process(GO:0006554)
0.0	0.0	GO:0090286	cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.0	0.0	GO:0045989	positive regulation of striated muscle contraction(GO:0045989)
0.0	0.0	GO:0035283	central nervous system segmentation(GO:0035283) brain segmentation(GO:0035284)
0.0	0.0	GO:0060596	mammary placode formation(GO:0060596)
0.0	0.0	GO:0032656	regulation of interleukin-13 production(GO:0032656)
0.0	0.1	GO:0060216	definitive hemopoiesis(GO:0060216)
0.0	0.2	GO:0006825	copper ion transport(GO:0006825)
0.0	0.1	GO:0048148	behavioral response to cocaine(GO:0048148)
0.0	0.2	GO:0045773	positive regulation of axon extension(GO:0045773)
0.0	0.1	GO:0001547	antral ovarian follicle growth(GO:0001547)
0.0	0.0	GO:0090224	regulation of spindle organization(GO:0090224)
0.0	0.0	GO:0030854	positive regulation of granulocyte differentiation(GO:0030854)
0.0	0.0	GO:0046831	regulation of RNA export from nucleus(GO:0046831)
0.0	0.1	GO:0016553	base conversion or substitution editing(GO:0016553)
0.0	0.0	GO:0031053	primary miRNA processing(GO:0031053)
0.0	0.0	GO:0006269	DNA replication, synthesis of RNA primer(GO:0006269)
0.0	0.2	GO:0035336	long-chain fatty-acyl-CoA metabolic process(GO:0035336) long-chain fatty-acyl-CoA biosynthetic process(GO:0035338)
0.0	0.0	GO:0071803	regulation of podosome assembly(GO:0071801) positive regulation of podosome assembly(GO:0071803)
0.0	0.0	GO:0060633	negative regulation of transcription initiation from RNA polymerase II promoter(GO:0060633) negative regulation of DNA-templated transcription, initiation(GO:2000143)
0.0	0.1	GO:0006108	malate metabolic process(GO:0006108)
0.0	0.0	GO:0051305	chromosome movement towards spindle pole(GO:0051305)
0.0	0.0	GO:0071692	sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)

Gene overrepresentation in cellular component category:

Total log-likelihood	Term	Description
0.2	GO:0031307	integral component of mitochondrial outer membrane(GO:0031307)
0.2	GO:0014701	junctional sarcoplasmic reticulum membrane(GO:0014701)
0.1	GO:0043218	compact myelin(GO:0043218)
0.1	GO:0005900	oncostatin-M receptor complex(GO:0005900)
0.1	GO:0044224	juxtaparanode region of axon(GO:0044224)
0.0	GO:0033270	paranode region of axon(GO:0033270)
0.2	GO:0002102	podosome(GO:0002102)
0.1	GO:0005593	FACIT collagen trimer(GO:0005593)
0.1	GO:0071438	invadopodium membrane(GO:0071438)
0.1	GO:0043259	laminin-10 complex(GO:0043259)
0.1	GO:0005954	calcium- and calmodulin-dependent protein kinase complex(GO:0005954)
0.1	GO:0043159	acrosomal matrix(GO:0043159)
0.1	GO:0030893	meiotic cohesin complex(GO:0030893)
0.0	GO:0032045	guanyl-nucleotide exchange factor complex(GO:0032045)
0.2	GO:0071564	npBAF complex(GO:0071564)
0.0	GO:0071437	invadopodium(GO:0071437)
0.2	GO:0032039	integrator complex(GO:0032039)
0.1	GO:0031512	motile primary cilium(GO:0031512)
0.1	GO:0034993	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.1	GO:0032839	dendrite cytoplasm(GO:0032839)
0.1	GO:0042598	obsolete vesicular fraction(GO:0042598)
0.0	GO:0031618	nuclear pericentric heterochromatin(GO:0031618)
0.0	GO:0005641	nuclear envelope lumen(GO:0005641)
0.0	GO:0030904	retromer complex(GO:0030904)
0.1	GO:0005828	kinetochore microtubule(GO:0005828)
0.0	GO:0031931	TORC1 complex(GO:0031931)
0.0	GO:0005589	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0019166	trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166)
0.1	0.2	GO:0045545	syndecan binding(GO:0045545)
0.1	0.2	GO:0050220	prostaglandin-E synthase activity(GO:0050220)
0.0	0.3	GO:0016290	palmitoyl-CoA hydrolase activity(GO:0016290)
0.0	0.1	GO:0070644	vitamin D response element binding(GO:0070644)
0.0	0.2	GO:0008429	phosphatidylethanolamine binding(GO:0008429)
0.0	0.2	GO:0031435	mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0	0.1	GO:0004967	glucagon receptor activity(GO:0004967)
0.0	0.1	GO:0016724	ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0	0.1	GO:0008332	low voltage-gated calcium channel activity(GO:0008332)
0.0	0.1	GO:0048018	receptor agonist activity(GO:0048018)
0.0	0.1	GO:0030618	transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0	0.1	GO:0004013	adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0	0.1	GO:0019215	intermediate filament binding(GO:0019215)
0.0	0.1	GO:0031702	type 1 angiotensin receptor binding(GO:0031702)
0.0	0.1	GO:0000828	inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832)
0.0	0.1	GO:0015226	amino-acid betaine transmembrane transporter activity(GO:0015199) carnitine transmembrane transporter activity(GO:0015226)
0.0	0.1	GO:0005412	glucose:sodium symporter activity(GO:0005412)
0.0	0.0	GO:0030215	semaphorin receptor binding(GO:0030215)
0.0	0.1	GO:0017154	semaphorin receptor activity(GO:0017154)
0.0	0.1	GO:0001758	retinal dehydrogenase activity(GO:0001758)
0.0	0.1	GO:0004862	cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0	0.1	GO:0005332	gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.0	0.1	GO:0017162	aryl hydrocarbon receptor binding(GO:0017162)
0.0	0.1	GO:0004470	malic enzyme activity(GO:0004470)
0.0	0.1	GO:0008510	sodium:bicarbonate symporter activity(GO:0008510)
0.0	0.1	GO:0004656	procollagen-proline 4-dioxygenase activity(GO:0004656) peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.0	0.1	GO:0019911	structural constituent of myelin sheath(GO:0019911)
0.0	0.1	GO:0015057	thrombin receptor activity(GO:0015057)
0.0	0.1	GO:0008046	axon guidance receptor activity(GO:0008046)
0.0	0.1	GO:0043495	protein anchor(GO:0043495)
0.0	0.4	GO:0005520	insulin-like growth factor binding(GO:0005520)
0.0	0.1	GO:0043515	kinetochore binding(GO:0043515)
0.0	0.1	GO:0070548	L-glutamine aminotransferase activity(GO:0070548)
0.0	0.1	GO:0005114	type II transforming growth factor beta receptor binding(GO:0005114)
0.0	0.0	GO:0044020	histone methyltransferase activity (H4-R3 specific)(GO:0044020)
0.0	0.1	GO:0004568	chitinase activity(GO:0004568)
0.0	0.1	GO:0004157	dihydropyrimidinase activity(GO:0004157)
0.0	0.1	GO:0017080	sodium channel regulator activity(GO:0017080)
0.0	0.0	GO:0042808	obsolete neuronal Cdc2-like kinase binding(GO:0042808)
0.0	0.0	GO:0070052	collagen V binding(GO:0070052)
0.0	0.1	GO:0016565	obsolete general transcriptional repressor activity(GO:0016565)
0.0	0.1	GO:0005522	profilin binding(GO:0005522)
0.0	0.0	GO:0005350	pyrimidine nucleobase transmembrane transporter activity(GO:0005350)
0.0	0.1	GO:0042166	acetylcholine binding(GO:0042166)
0.0	0.0	GO:0003896	DNA primase activity(GO:0003896)
0.0	0.3	GO:0008093	cytoskeletal adaptor activity(GO:0008093)
0.0	0.1	GO:0000014	single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.0	0.1	GO:0044548	S100 protein binding(GO:0044548)
0.0	0.1	GO:0003873	6-phosphofructo-2-kinase activity(GO:0003873)
0.0	0.2	GO:0005540	hyaluronic acid binding(GO:0005540)
0.0	0.0	GO:0004924	oncostatin-M receptor activity(GO:0004924)
0.0	0.0	GO:0004591	oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.0	0.1	GO:0008649	rRNA methyltransferase activity(GO:0008649)
0.0	0.1	GO:0030020	extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.0	0.1	GO:0048407	platelet-derived growth factor binding(GO:0048407)
0.0	0.1	GO:0005000	vasopressin receptor activity(GO:0005000)
0.0	0.1	GO:0070579	methylcytosine dioxygenase activity(GO:0070579)
0.0	0.1	GO:0030247	pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0	0.0	GO:0031708	bombesin receptor binding(GO:0031705) endothelin B receptor binding(GO:0031708)
0.0	0.1	GO:0043274	phospholipase binding(GO:0043274)
0.0	0.1	GO:0098988	adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640) G-protein coupled glutamate receptor activity(GO:0098988)
0.0	0.1	GO:0055056	D-glucose transmembrane transporter activity(GO:0055056)
0.0	0.2	GO:0005003	ephrin receptor activity(GO:0005003)
0.0	0.0	GO:0004103	choline kinase activity(GO:0004103)
0.0	0.0	GO:0030284	estrogen receptor activity(GO:0030284)
0.0	0.0	GO:0004849	uridine kinase activity(GO:0004849)
0.0	0.1	GO:0008239	dipeptidyl-peptidase activity(GO:0008239)
0.0	0.0	GO:0004142	diacylglycerol cholinephosphotransferase activity(GO:0004142)
0.0	0.0	GO:0004735	pyrroline-5-carboxylate reductase activity(GO:0004735)
0.0	0.1	GO:0045502	dynein binding(GO:0045502)
0.0	0.0	GO:0019211	phosphatase activator activity(GO:0019211)
0.0	0.1	GO:0043539	protein serine/threonine kinase activator activity(GO:0043539)
0.0	0.1	GO:0008889	glycerophosphodiester phosphodiesterase activity(GO:0008889)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.4	PID HEDGEHOG 2PATHWAY	Signaling events mediated by the Hedgehog family
0.0	PID INSULIN PATHWAY	Insulin Pathway
0.0	PID TXA2PATHWAY	Thromboxane A2 receptor signaling
0.6	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.1	SA G1 AND S PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.0	PID IL2 PI3K PATHWAY	IL2 signaling events mediated by PI3K
0.3	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
0.0	PID PI3K PLC TRK PATHWAY	Trk receptor signaling mediated by PI3K and PLC-gamma
0.1	PID NETRIN PATHWAY	Netrin-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.0	REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS	Genes involved in Membrane binding and targetting of GAG proteins
0.0	REACTOME FRS2 MEDIATED CASCADE	Genes involved in FRS2-mediated cascade
0.3	REACTOME SEMA3A PAK DEPENDENT AXON REPULSION	Genes involved in Sema3A PAK dependent Axon repulsion
0.0	REACTOME CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION	Genes involved in Cleavage of Growing Transcript in the Termination Region
0.4	REACTOME METAL ION SLC TRANSPORTERS	Genes involved in Metal ion SLC transporters
0.1	REACTOME COPI MEDIATED TRANSPORT	Genes involved in COPI Mediated Transport
0.2	REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS	Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.2	REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE	Genes involved in Synthesis of PIPs at the early endosome membrane
0.0	REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB	Genes involved in PKA-mediated phosphorylation of CREB
0.3	REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING	Genes involved in Downregulation of TGF-beta receptor signaling
0.1	REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1	Genes involved in IKK complex recruitment mediated by RIP1
0.1	REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE	Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.0	REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Glutamate Neurotransmitter Release Cycle
0.1	REACTOME CRMPS IN SEMA3A SIGNALING	Genes involved in CRMPs in Sema3A signaling
0.1	REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex