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ENCODE: H3K4me1 ChIP-Seq of primary human cells
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Results for RELA

Z-value: 1.25

Motif logo

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Transcription factors associated with RELA

Gene Symbol Gene ID Gene Info
ENSG00000173039.14 RELA proto-oncogene, NF-kB subunit

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr11_65429605_65429909RELA1420.903658-0.791.2e-02Click!
chr11_65428971_65429545RELA6410.500183-0.675.0e-02Click!
chr11_65430900_65431059RELA4140.682070-0.599.4e-02Click!
chr11_65431282_65431834RELA9930.326887-0.472.0e-01Click!
chr11_65424945_65425096RELA21940.142375-0.284.6e-01Click!

Activity of the RELA motif across conditions

Conditions sorted by the z-value of the RELA motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr19_13120371_13120965 0.88 NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
2334
0.15
chr5_14055268_14055419 0.68 TRIO
trio Rho guanine nucleotide exchange factor
88468
0.1
chr2_64431477_64431968 0.66 AC074289.1

2387
0.38
chr14_25518403_25519489 0.61 STXBP6
syntaxin binding protein 6 (amisyn)
149
0.98
chr1_111735380_111736106 0.59 DENND2D
DENN/MADD domain containing 2D
7568
0.12
chr10_134224918_134226015 0.57 PWWP2B
PWWP domain containing 2B
14764
0.17
chr1_16479115_16479478 0.57 RP11-276H7.2

2410
0.18
chr14_69014642_69014793 0.54 CTD-2325P2.4

80445
0.1
chr10_112288804_112288973 0.53 DUSP5
dual specificity phosphatase 5
31292
0.13
chr12_28019839_28019990 0.53 ENSG00000201612
.
60591
0.09
chr4_24227998_24228149 0.51 ENSG00000222262
.
194851
0.03
chr7_28077677_28077828 0.50 JAZF1
JAZF zinc finger 1
17334
0.25
chr5_131599252_131599414 0.50 PDLIM4
PDZ and LIM domain 4
2191
0.26
chr10_60617108_60617259 0.50 ENSG00000252076
.
11761
0.28
chr21_36217039_36217945 0.49 RUNX1
runt-related transcription factor 1
41988
0.19
chr12_398019_398170 0.49 RP11-283I3.6

11805
0.15
chr4_37695342_37695493 0.49 ENSG00000207075
.
6207
0.23
chr19_42626039_42626662 0.49 POU2F2
POU class 2 homeobox 2
382
0.74
chr20_62330262_62330413 0.48 TNFRSF6B
tumor necrosis factor receptor superfamily, member 6b, decoy
2316
0.13
chr5_142563019_142563312 0.46 ARHGAP26-IT1
ARHGAP26 intronic transcript 1 (non-protein coding)
8900
0.26
chr9_136738727_136738896 0.46 VAV2
vav 2 guanine nucleotide exchange factor
118592
0.05
chr8_94918337_94918663 0.46 ENSG00000264448
.
9847
0.19
chr1_246754834_246755065 0.46 RP11-439E19.1

14226
0.17
chr2_19132169_19132320 0.45 NT5C1B
5'-nucleotidase, cytosolic IB
361406
0.01
chr7_5971680_5971831 0.44 RSPH10B
radial spoke head 10 homolog B (Chlamydomonas)
26959
0.11
chr5_140901959_140902110 0.44 DIAPH1
diaphanous-related formin 1
3680
0.13
chr1_155436245_155436396 0.44 ENSG00000207144
.
47132
0.09
chr1_215361477_215361628 0.44 KCNK2
potassium channel, subfamily K, member 2
104692
0.08
chr1_19774465_19775000 0.44 ENSG00000240490
.
23854
0.14
chr15_85473411_85473562 0.43 ENSG00000207037
.
8267
0.16
chr1_235123444_235123890 0.43 ENSG00000239690
.
83734
0.09
chr2_145116564_145116715 0.42 GTDC1
glycosyltransferase-like domain containing 1
26556
0.24
chr17_75251839_75251990 0.42 SEPT9
septin 9
24737
0.19
chr9_114791054_114791349 0.42 RP11-4O1.2

7389
0.21
chr3_62598104_62598255 0.42 CADPS
Ca++-dependent secretion activator
27258
0.26
chr6_166980327_166980478 0.41 RPS6KA2
ribosomal protein S6 kinase, 90kDa, polypeptide 2
22224
0.19
chr2_122121105_122121256 0.41 CLASP1
cytoplasmic linker associated protein 1
63866
0.13
chr7_110753696_110753847 0.41 ENSG00000238922
.
4358
0.29
chr22_30646914_30647065 0.41 LIF
leukemia inhibitory factor
4149
0.12
chr1_52024489_52024927 0.41 OSBPL9
oxysterol binding protein-like 9
18143
0.15
chr1_14847140_14847291 0.40 KAZN
kazrin, periplakin interacting protein
77985
0.12
chr4_57945701_57945852 0.40 ENSG00000238541
.
26735
0.14
chr6_135229867_135230018 0.40 ALDH8A1
aldehyde dehydrogenase 8 family, member A1
20357
0.21
chr2_112153168_112153719 0.40 ENSG00000266139
.
74775
0.13
chr10_80916996_80917718 0.40 ZMIZ1
zinc finger, MIZ-type containing 1
88565
0.09
chr14_77370831_77371251 0.39 ENSG00000223174
.
14435
0.2
chr6_54057923_54058074 0.39 MLIP
muscular LMNA-interacting protein
81690
0.1
chr2_219757049_219757365 0.39 WNT10A
wingless-type MMTV integration site family, member 10A
10324
0.11
chr22_32447005_32447156 0.39 SLC5A1
solute carrier family 5 (sodium/glucose cotransporter), member 1
8061
0.19
chr13_110780415_110780566 0.39 ENSG00000265885
.
29992
0.24
chr12_48124290_48124441 0.39 ENDOU
endonuclease, polyU-specific
5015
0.17
chr9_117110893_117111174 0.38 AKNA
AT-hook transcription factor
189
0.95
chr1_33761314_33761465 0.38 RP11-415J8.3

11578
0.13
chr1_16508178_16508413 0.38 ARHGEF19-AS1
ARHGEF19 antisense RNA 1
16054
0.1
chr19_50289714_50289865 0.38 AP2A1
adaptor-related protein complex 2, alpha 1 subunit
19398
0.06
chr6_37521261_37521499 0.38 ENSG00000263926
.
1818
0.41
chr17_79949976_79950203 0.37 ASPSCR1
alveolar soft part sarcoma chromosome region, candidate 1
3230
0.09
chr3_126721307_126721580 0.37 PLXNA1
plexin A1
14006
0.29
chr2_204468904_204469055 0.37 RAPH1
Ras association (RalGDS/AF-6) and pleckstrin homology domains 1
68846
0.12
chr7_151387438_151387589 0.36 PRKAG2
protein kinase, AMP-activated, gamma 2 non-catalytic subunit
45836
0.15
chr2_218576039_218576190 0.36 DIRC3
disrupted in renal carcinoma 3
45164
0.19
chr7_73983441_73983592 0.36 ENSG00000252378
.
2161
0.33
chr9_136821628_136822276 0.36 VAV2
vav 2 guanine nucleotide exchange factor
35451
0.17
chr5_88579017_88579168 0.35 MEF2C-AS1
MEF2C antisense RNA 1
135532
0.06
chr8_124529392_124529769 0.35 FBXO32
F-box protein 32
23866
0.18
chr2_113735290_113735441 0.35 IL36G
interleukin 36, gamma
231
0.92
chr2_235578887_235579038 0.34 ARL4C
ADP-ribosylation factor-like 4C
173265
0.04
chr21_43459806_43459957 0.34 UMODL1
uromodulin-like 1
23187
0.16
chr8_19869720_19869871 0.34 AC100802.3

67021
0.12
chr4_106108196_106108347 0.34 TET2-AS1
TET2 antisense RNA 1
9051
0.24
chr5_81459991_81460142 0.34 ENSG00000265684
.
85820
0.08
chr12_28119783_28119934 0.34 PTHLH
parathyroid hormone-like hormone
2569
0.31
chr1_230249285_230249570 0.33 GALNT2
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 (GalNAc-T2)
46409
0.16
chr22_36720442_36720593 0.33 ENSG00000266345
.
8271
0.19
chr1_25691144_25691295 0.33 ENSG00000238889
.
18351
0.11
chr8_43046499_43046650 0.33 HGSNAT
heparan-alpha-glucosaminide N-acetyltransferase
11142
0.22
chr20_32922542_32922693 0.33 AHCY
adenosylhomocysteinase
23009
0.13
chr7_492646_493023 0.33 PDGFA
platelet-derived growth factor alpha polypeptide
65311
0.11
chr7_31988455_31988606 0.32 PDE1C
phosphodiesterase 1C, calmodulin-dependent 70kDa
121931
0.06
chr5_17186685_17186836 0.32 ENSG00000251990
.
29580
0.14
chr6_9521428_9521579 0.32 OFCC1
orofacial cleft 1 candidate 1
411997
0.01
chr1_23801357_23801508 0.32 ASAP3
ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
9239
0.18
chr18_33889238_33889389 0.32 FHOD3
formin homology 2 domain containing 3
11514
0.27
chr14_77773550_77773731 0.32 POMT2
protein-O-mannosyltransferase 2
13043
0.12
chr1_39758697_39758848 0.32 MACF1
microtubule-actin crosslinking factor 1
7214
0.22
chr1_37945557_37946349 0.32 ZC3H12A
zinc finger CCCH-type containing 12A
1338
0.36
chr16_86964951_86965102 0.31 RP11-899L11.3

284495
0.01
chr7_5733225_5733376 0.31 RNF216-IT1
RNF216 intronic transcript 1 (non-protein coding)
13208
0.2
chr16_67346089_67346240 0.31 KCTD19
potassium channel tetramerization domain containing 19
9649
0.09
chr5_71698297_71698448 0.31 RP11-389C8.2

39842
0.16
chr8_122835118_122835355 0.31 HAS2-AS1
HAS2 antisense RNA 1
181560
0.03
chr20_13211744_13212262 0.31 ISM1-AS1
ISM1 antisense RNA 1
8318
0.2
chr10_124136204_124136523 0.31 PLEKHA1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
2013
0.32
chr7_17412244_17412395 0.31 ENSG00000199473
.
631
0.81
chr11_114217659_114217947 0.31 RP11-64D24.2

9490
0.18
chr22_51020006_51020440 0.31 CHKB
choline kinase beta
1205
0.2
chr9_117826218_117826369 0.31 TNC
tenascin C
898
0.71
chr19_39176650_39177321 0.31 CTB-186G2.4

7261
0.12
chr19_46080635_46080786 0.31 OPA3
optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
7367
0.12
chr17_38336562_38336713 0.31 RAPGEFL1
Rap guanine nucleotide exchange factor (GEF)-like 1
854
0.5
chr16_68321146_68321898 0.31 ENSG00000252026
.
3301
0.1
chr2_102081509_102081660 0.30 RFX8
RFX family member 8, lacking RFX DNA binding domain
9153
0.27
chr8_128821695_128821987 0.30 ENSG00000249859
.
13633
0.26
chr1_201992311_201992462 0.30 RP11-510N19.5

11888
0.11
chr6_45559057_45559277 0.30 ENSG00000252738
.
54674
0.17
chr3_137762283_137762711 0.30 DZIP1L
DAZ interacting zinc finger protein 1-like
23985
0.17
chr10_126723650_126723801 0.30 ENSG00000264572
.
2286
0.32
chr11_119438556_119438707 0.30 RP11-196E1.3

40504
0.15
chr10_128109942_128110093 0.30 ADAM12
ADAM metallopeptidase domain 12
32993
0.19
chr8_32126966_32127117 0.30 ENSG00000200246
.
13029
0.24
chr11_118786204_118786601 0.30 BCL9L
B-cell CLL/lymphoma 9-like
3211
0.11
chr5_5340745_5341045 0.30 KIAA0947
KIAA0947
81912
0.11
chr11_102470906_102471057 0.30 RP11-817J15.2

6666
0.19
chr10_33320919_33321292 0.30 ENSG00000265319
.
2747
0.32
chr5_52630256_52630554 0.29 FST
follistatin
145834
0.04
chr11_118782916_118784128 0.29 BCL9L
B-cell CLL/lymphoma 9-like
1909
0.16
chr1_201265444_201265595 0.29 PKP1
plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)
12688
0.19
chr2_87854693_87854844 0.29 ENSG00000265507
.
74506
0.11
chr5_54054265_54054416 0.29 ENSG00000221073
.
94436
0.08
chr7_74002155_74002306 0.29 ENSG00000252378
.
16553
0.2
chr2_120009918_120010346 0.29 STEAP3-AS1
STEAP3 antisense RNA 1
3485
0.25
chr13_44806372_44806666 0.29 SMIM2
small integral membrane protein 2
71126
0.11
chr7_92427069_92427220 0.29 CDK6
cyclin-dependent kinase 6
36087
0.17
chr15_89455158_89455741 0.29 MFGE8
milk fat globule-EGF factor 8 protein
1144
0.49
chr1_228268932_228269720 0.29 ARF1
ADP-ribosylation factor 1
1035
0.41
chr21_30464772_30464923 0.29 MAP3K7CL
MAP3K7 C-terminal like
272
0.88
chr17_79302865_79303213 0.29 TMEM105
transmembrane protein 105
1176
0.39
chr1_6419428_6419896 0.29 ACOT7
acyl-CoA thioesterase 7
258
0.9
chr10_29910095_29910342 0.29 SVIL
supervillin
13683
0.19
chr9_91144416_91144843 0.28 NXNL2
nucleoredoxin-like 2
5387
0.32
chr12_11908349_11908500 0.28 ETV6
ets variant 6
2989
0.38
chr17_38263559_38264452 0.28 NR1D1
nuclear receptor subfamily 1, group D, member 1
7027
0.12
chr19_47730648_47731306 0.28 ENSG00000265134
.
778
0.55
chr19_1546180_1546480 0.28 ENSG00000266399
.
7701
0.08
chr11_111392089_111392240 0.28 RP11-794P6.6

5316
0.11
chr2_235890567_235890856 0.27 SH3BP4
SH3-domain binding protein 4
443
0.91
chr5_177370096_177370366 0.27 RP11-1252I4.2

3608
0.18
chr3_114379229_114379380 0.27 ZBTB20
zinc finger and BTB domain containing 20
35512
0.22
chr13_106807816_106807967 0.27 ENSG00000222682
.
52
0.98
chr17_1686320_1687263 0.27 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
11778
0.11
chr2_221141967_221142118 0.27 ENSG00000221199
.
85443
0.1
chr4_108611767_108611918 0.27 PAPSS1
3'-phosphoadenosine 5'-phosphosulfate synthase 1
29766
0.23
chr11_35205869_35206020 0.27 CD44
CD44 molecule (Indian blood group)
2446
0.25
chr1_110470801_110470952 0.27 CSF1
colony stimulating factor 1 (macrophage)
17268
0.16
chr22_36406894_36407045 0.27 RBFOX2
RNA binding protein, fox-1 homolog (C. elegans) 2
17504
0.26
chr10_3930051_3930202 0.27 KLF6
Kruppel-like factor 6
102653
0.08
chr8_67424665_67424816 0.27 ENSG00000206949
.
11194
0.19
chr2_100422888_100423180 0.27 AFF3
AF4/FMR2 family, member 3
228202
0.02
chr9_114792336_114792610 0.27 RP11-4O1.2

6117
0.22
chr2_196440572_196441282 0.27 SLC39A10
solute carrier family 39 (zinc transporter), member 10
226
0.96
chr10_6243827_6244661 0.26 RP11-414H17.5

412
0.58
chr11_34255458_34256011 0.26 ENSG00000201867
.
45013
0.17
chr10_124220042_124220595 0.26 HTRA1
HtrA serine peptidase 1
723
0.66
chr16_72290694_72290845 0.26 PMFBP1
polyamine modulated factor 1 binding protein 1
79992
0.09
chr10_104408471_104409659 0.26 TRIM8
tripartite motif containing 8
4421
0.2
chr12_127610439_127610590 0.26 ENSG00000239776
.
40158
0.23
chr12_11975182_11975534 0.26 ETV6
ets variant 6
63513
0.14
chr4_157720350_157720504 0.26 RP11-154F14.2

42084
0.17
chr17_16311388_16311661 0.26 TRPV2
transient receptor potential cation channel, subfamily V, member 2
7332
0.13
chr16_89690125_89690276 0.26 DPEP1
dipeptidase 1 (renal)
3200
0.14
chr17_70123100_70123251 0.26 SOX9
SRY (sex determining region Y)-box 9
6014
0.33
chr1_59479041_59479192 0.26 JUN
jun proto-oncogene
229331
0.02
chr3_11507209_11507360 0.26 ATG7
autophagy related 7
101151
0.07
chr6_12025532_12025683 0.26 HIVEP1
human immunodeficiency virus type I enhancer binding protein 1
9787
0.26
chr7_101812750_101813040 0.26 ENSG00000252824
.
24549
0.18
chr20_32404981_32405132 0.26 CHMP4B
charged multivesicular body protein 4B
5946
0.18
chr6_41513317_41513955 0.26 RP11-328M4.2

176
0.81
chr16_88831505_88831885 0.26 PIEZO1
piezo-type mechanosensitive ion channel component 1
19924
0.07
chr16_8954168_8954319 0.25 CARHSP1
calcium regulated heat stable protein 1, 24kDa
1327
0.31
chr2_151377864_151378015 0.25 RND3
Rho family GTPase 3
17586
0.31
chr18_9416638_9416789 0.25 RALBP1
ralA binding protein 1
58294
0.1
chr2_38265057_38265550 0.25 RMDN2-AS1
RMDN2 antisense RNA 1
1819
0.36
chr4_41202697_41202848 0.25 APBB2
amyloid beta (A4) precursor protein-binding, family B, member 2
13703
0.2
chr22_31502717_31502868 0.25 SELM
Selenoprotein M
762
0.5
chr19_10045992_10046143 0.25 OLFM2
olfactomedin 2
1161
0.4
chr4_68580052_68580203 0.25 UBA6-AS1
UBA6 antisense RNA 1 (head to head)
13014
0.17
chr1_167744512_167744663 0.25 MPZL1
myelin protein zero-like 1
9780
0.23
chr10_104562844_104563157 0.25 ENSG00000252994
.
686
0.6
chr19_14672759_14672910 0.25 TECR
trans-2,3-enoyl-CoA reductase
55
0.95
chr17_4401391_4401902 0.25 SPNS2
spinster homolog 2 (Drosophila)
487
0.65
chr11_35034999_35035461 0.25 PDHX
pyruvate dehydrogenase complex, component X
35899
0.17
chr1_210573481_210573755 0.24 ENSG00000200972
.
26007
0.21
chr5_178806268_178806419 0.24 ADAMTS2
ADAM metallopeptidase with thrombospondin type 1 motif, 2
33912
0.19
chr6_125425186_125425448 0.24 TPD52L1
tumor protein D52-like 1
14878
0.26
chr4_72159835_72159986 0.24 SLC4A4
solute carrier family 4 (sodium bicarbonate cotransporter), member 4
44860
0.2
chr8_101514645_101514908 0.24 KB-1615E4.3

10020
0.18
chr22_41686786_41686937 0.24 AL035681.1

1175
0.36
chr19_46283041_46283318 0.24 DMPK
dystrophia myotonica-protein kinase
620
0.48
chr4_143285799_143285950 0.24 INPP4B
inositol polyphosphate-4-phosphatase, type II, 105kDa
58777
0.17
chr5_77814160_77814311 0.24 LHFPL2
lipoma HMGIC fusion partner-like 2
30739
0.24
chr1_110435299_110435450 0.24 RP11-195M16.1

6488
0.19
chr4_74864472_74864623 0.24 CXCL5
chemokine (C-X-C motif) ligand 5
51
0.96
chr13_41092746_41092897 0.24 AL133318.1
Uncharacterized protein
18502
0.26
chr4_106816798_106817272 0.24 INTS12
integrator complex subunit 12
108
0.67
chr10_133794328_133795175 0.24 BNIP3
BCL2/adenovirus E1B 19kDa interacting protein 3
676
0.77
chr6_10735071_10735222 0.24 TMEM14C
transmembrane protein 14C
11938
0.12
chr15_40339457_40340106 0.24 SRP14
signal recognition particle 14kDa (homologous Alu RNA binding protein)
8392
0.16
chr14_23316976_23317711 0.24 ENSG00000212335
.
4594
0.09
chr1_156073569_156073968 0.24 LMNA
lamin A/C
10693
0.1
chr5_137566220_137566371 0.24 CDC23
cell division cycle 23
17263
0.12

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of RELA

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0060648 mammary gland bud morphogenesis(GO:0060648)
0.1 0.2 GO:0060426 lung vasculature development(GO:0060426)
0.0 0.1 GO:0006883 cellular sodium ion homeostasis(GO:0006883)
0.0 0.2 GO:0071364 cellular response to epidermal growth factor stimulus(GO:0071364)
0.0 0.1 GO:0019049 evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.0 0.1 GO:1902339 apoptotic process involved in mammary gland involution(GO:0060057) positive regulation of apoptotic process involved in mammary gland involution(GO:0060058) positive regulation of apoptotic process involved in morphogenesis(GO:1902339) regulation of mammary gland involution(GO:1903519) positive regulation of mammary gland involution(GO:1903521) positive regulation of apoptotic process involved in development(GO:1904747)
0.0 0.2 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.0 0.1 GO:0034201 response to oleic acid(GO:0034201)
0.0 0.1 GO:0070050 neuron cellular homeostasis(GO:0070050)
0.0 0.2 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
0.0 0.1 GO:0048319 axial mesoderm morphogenesis(GO:0048319)
0.0 0.1 GO:0045657 positive regulation of monocyte differentiation(GO:0045657)
0.0 0.1 GO:0072577 endothelial cell apoptotic process(GO:0072577) epithelial cell apoptotic process(GO:1904019) regulation of epithelial cell apoptotic process(GO:1904035) regulation of endothelial cell apoptotic process(GO:2000351)
0.0 0.0 GO:0060831 smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:0060831)
0.0 0.1 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.0 0.1 GO:0022007 neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007)
0.0 0.1 GO:0014819 regulation of skeletal muscle contraction(GO:0014819)
0.0 0.1 GO:0034139 regulation of toll-like receptor 3 signaling pathway(GO:0034139)
0.0 0.1 GO:0021631 optic nerve morphogenesis(GO:0021631)
0.0 0.1 GO:0010511 regulation of phosphatidylinositol biosynthetic process(GO:0010511)
0.0 0.2 GO:0060638 mesenchymal-epithelial cell signaling(GO:0060638)
0.0 0.1 GO:0021898 commitment of multipotent stem cells to neuronal lineage in forebrain(GO:0021898)
0.0 0.0 GO:0060449 bud elongation involved in lung branching(GO:0060449)
0.0 0.1 GO:0060453 regulation of gastric acid secretion(GO:0060453)
0.0 0.1 GO:0015820 branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820)
0.0 0.1 GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.0 0.1 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) 4-hydroxyproline metabolic process(GO:0019471) peptidyl-proline hydroxylation(GO:0019511)
0.0 0.1 GO:0042996 regulation of Golgi to plasma membrane protein transport(GO:0042996)
0.0 0.2 GO:0008634 obsolete negative regulation of survival gene product expression(GO:0008634)
0.0 0.1 GO:0007132 meiotic metaphase I(GO:0007132)
0.0 0.1 GO:0006391 transcription initiation from mitochondrial promoter(GO:0006391)
0.0 0.1 GO:0006295 nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295)
0.0 0.1 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0 0.1 GO:0034626 fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 0.1 GO:0045542 positive regulation of cholesterol biosynthetic process(GO:0045542)
0.0 0.1 GO:0000103 sulfate assimilation(GO:0000103)
0.0 0.1 GO:0061318 renal filtration cell differentiation(GO:0061318) glomerular epithelium development(GO:0072010) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.0 0.0 GO:0072216 positive regulation of metanephros development(GO:0072216)
0.0 0.1 GO:0010716 regulation of extracellular matrix disassembly(GO:0010715) negative regulation of extracellular matrix disassembly(GO:0010716) regulation of extracellular matrix organization(GO:1903053) negative regulation of extracellular matrix organization(GO:1903054)
0.0 0.1 GO:0045830 positive regulation of isotype switching(GO:0045830)
0.0 0.1 GO:0001973 adenosine receptor signaling pathway(GO:0001973) G-protein coupled purinergic receptor signaling pathway(GO:0035588)
0.0 0.2 GO:0032456 endocytic recycling(GO:0032456)
0.0 0.0 GO:0060433 bronchus development(GO:0060433)
0.0 0.1 GO:0045350 interferon-beta biosynthetic process(GO:0045350) regulation of interferon-beta biosynthetic process(GO:0045357) positive regulation of interferon-beta biosynthetic process(GO:0045359)
0.0 0.1 GO:0006910 phagocytosis, recognition(GO:0006910)
0.0 0.2 GO:0033327 Leydig cell differentiation(GO:0033327)
0.0 0.0 GO:0048368 lateral mesoderm development(GO:0048368)
0.0 0.1 GO:0007000 nucleolus organization(GO:0007000)
0.0 0.1 GO:0018242 protein O-linked glycosylation via serine(GO:0018242) protein O-linked glycosylation via threonine(GO:0018243)
0.0 0.1 GO:0042574 retinal metabolic process(GO:0042574)
0.0 0.0 GO:0045835 negative regulation of meiotic nuclear division(GO:0045835)
0.0 0.0 GO:0060584 regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
0.0 0.1 GO:0009106 lipoate metabolic process(GO:0009106)
0.0 0.0 GO:0002513 tolerance induction to self antigen(GO:0002513)
0.0 0.1 GO:0036072 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.0 0.1 GO:0032926 negative regulation of activin receptor signaling pathway(GO:0032926)
0.0 0.1 GO:0048200 COPI-coated vesicle budding(GO:0035964) Golgi vesicle budding(GO:0048194) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)
0.0 0.0 GO:0033173 calcineurin-NFAT signaling cascade(GO:0033173)
0.0 0.1 GO:0006032 chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.0 0.1 GO:0007520 myoblast fusion(GO:0007520)
0.0 0.1 GO:0007028 cytoplasm organization(GO:0007028)
0.0 0.0 GO:0060083 smooth muscle contraction involved in micturition(GO:0060083)
0.0 0.1 GO:0032958 inositol phosphate biosynthetic process(GO:0032958)
0.0 0.0 GO:0048289 isotype switching to IgE isotypes(GO:0048289) regulation of isotype switching to IgE isotypes(GO:0048293)
0.0 0.1 GO:0090218 positive regulation of lipid kinase activity(GO:0090218)
0.0 0.0 GO:0010761 fibroblast migration(GO:0010761)
0.0 0.1 GO:0045066 regulatory T cell differentiation(GO:0045066)
0.0 0.2 GO:0016180 snRNA processing(GO:0016180)
0.0 0.1 GO:0010799 regulation of peptidyl-threonine phosphorylation(GO:0010799)
0.0 0.0 GO:0090085 regulation of protein deubiquitination(GO:0090085)
0.0 0.0 GO:0033603 positive regulation of dopamine secretion(GO:0033603)
0.0 0.1 GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity(GO:0060314)
0.0 0.1 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.0 0.1 GO:0035413 positive regulation of catenin import into nucleus(GO:0035413)
0.0 0.0 GO:0032714 negative regulation of interleukin-5 production(GO:0032714)
0.0 0.1 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.0 0.1 GO:0046952 ketone body catabolic process(GO:0046952)
0.0 0.1 GO:0070493 thrombin receptor signaling pathway(GO:0070493)
0.0 0.1 GO:0043985 histone H4-R3 methylation(GO:0043985)
0.0 0.1 GO:0006448 regulation of translational elongation(GO:0006448)
0.0 0.1 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0 0.0 GO:0048302 regulation of isotype switching to IgG isotypes(GO:0048302)
0.0 0.0 GO:0043578 nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0 0.0 GO:0060907 positive regulation of macrophage cytokine production(GO:0060907)
0.0 0.2 GO:0001516 prostaglandin biosynthetic process(GO:0001516) prostanoid biosynthetic process(GO:0046457)
0.0 0.1 GO:0032897 negative regulation of viral transcription(GO:0032897)
0.0 0.0 GO:0046476 glycosylceramide biosynthetic process(GO:0046476)
0.0 0.0 GO:0007343 egg activation(GO:0007343)
0.0 0.1 GO:1901797 negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518) negative regulation of signal transduction by p53 class mediator(GO:1901797)
0.0 0.1 GO:0070170 regulation of tooth mineralization(GO:0070170)
0.0 0.0 GO:0060528 secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.0 0.0 GO:0022417 protein maturation by protein folding(GO:0022417)
0.0 0.1 GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0 0.0 GO:0010934 macrophage cytokine production(GO:0010934) regulation of macrophage cytokine production(GO:0010935)
0.0 0.0 GO:0010837 regulation of keratinocyte proliferation(GO:0010837)
0.0 0.0 GO:0048861 leukemia inhibitory factor signaling pathway(GO:0048861)
0.0 0.1 GO:0045907 positive regulation of vasoconstriction(GO:0045907)
0.0 0.1 GO:0006553 lysine metabolic process(GO:0006553) lysine catabolic process(GO:0006554)
0.0 0.0 GO:0090286 cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.0 0.0 GO:0045989 positive regulation of striated muscle contraction(GO:0045989)
0.0 0.0 GO:0035283 central nervous system segmentation(GO:0035283) brain segmentation(GO:0035284)
0.0 0.0 GO:0060596 mammary placode formation(GO:0060596)
0.0 0.0 GO:0032656 regulation of interleukin-13 production(GO:0032656)
0.0 0.1 GO:0060216 definitive hemopoiesis(GO:0060216)
0.0 0.2 GO:0006825 copper ion transport(GO:0006825)
0.0 0.1 GO:0048148 behavioral response to cocaine(GO:0048148)
0.0 0.2 GO:0045773 positive regulation of axon extension(GO:0045773)
0.0 0.1 GO:0001547 antral ovarian follicle growth(GO:0001547)
0.0 0.0 GO:0090224 regulation of spindle organization(GO:0090224)
0.0 0.0 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.0 0.0 GO:0046831 regulation of RNA export from nucleus(GO:0046831)
0.0 0.1 GO:0016553 base conversion or substitution editing(GO:0016553)
0.0 0.0 GO:0031053 primary miRNA processing(GO:0031053)
0.0 0.0 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
0.0 0.2 GO:0035336 long-chain fatty-acyl-CoA metabolic process(GO:0035336) long-chain fatty-acyl-CoA biosynthetic process(GO:0035338)
0.0 0.0 GO:0071803 regulation of podosome assembly(GO:0071801) positive regulation of podosome assembly(GO:0071803)
0.0 0.0 GO:0060633 negative regulation of transcription initiation from RNA polymerase II promoter(GO:0060633) negative regulation of DNA-templated transcription, initiation(GO:2000143)
0.0 0.1 GO:0006108 malate metabolic process(GO:0006108)
0.0 0.0 GO:0051305 chromosome movement towards spindle pole(GO:0051305)
0.0 0.0 GO:0071692 sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 0.2 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.0 0.1 GO:0043218 compact myelin(GO:0043218)
0.0 0.1 GO:0005900 oncostatin-M receptor complex(GO:0005900)
0.0 0.1 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 0.0 GO:0033270 paranode region of axon(GO:0033270)
0.0 0.2 GO:0002102 podosome(GO:0002102)
0.0 0.1 GO:0005593 FACIT collagen trimer(GO:0005593)
0.0 0.1 GO:0071438 invadopodium membrane(GO:0071438)
0.0 0.1 GO:0043259 laminin-10 complex(GO:0043259)
0.0 0.1 GO:0005954 calcium- and calmodulin-dependent protein kinase complex(GO:0005954)
0.0 0.1 GO:0043159 acrosomal matrix(GO:0043159)
0.0 0.1 GO:0030893 meiotic cohesin complex(GO:0030893)
0.0 0.0 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.2 GO:0071564 npBAF complex(GO:0071564)
0.0 0.0 GO:0071437 invadopodium(GO:0071437)
0.0 0.2 GO:0032039 integrator complex(GO:0032039)
0.0 0.1 GO:0031512 motile primary cilium(GO:0031512)
0.0 0.1 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 0.1 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 0.1 GO:0042598 obsolete vesicular fraction(GO:0042598)
0.0 0.0 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.0 0.0 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.0 GO:0030904 retromer complex(GO:0030904)
0.0 0.1 GO:0005828 kinetochore microtubule(GO:0005828)
0.0 0.0 GO:0031931 TORC1 complex(GO:0031931)
0.0 0.0 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0019166 trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166)
0.1 0.2 GO:0045545 syndecan binding(GO:0045545)
0.1 0.2 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
0.0 0.3 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.0 0.1 GO:0070644 vitamin D response element binding(GO:0070644)
0.0 0.2 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.0 0.2 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0 0.1 GO:0004967 glucagon receptor activity(GO:0004967)
0.0 0.1 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0 0.1 GO:0008332 low voltage-gated calcium channel activity(GO:0008332)
0.0 0.1 GO:0048018 receptor agonist activity(GO:0048018)
0.0 0.1 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0 0.1 GO:0004013 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0 0.1 GO:0019215 intermediate filament binding(GO:0019215)
0.0 0.1 GO:0031702 type 1 angiotensin receptor binding(GO:0031702)
0.0 0.1 GO:0000828 inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832)
0.0 0.1 GO:0015226 amino-acid betaine transmembrane transporter activity(GO:0015199) carnitine transmembrane transporter activity(GO:0015226)
0.0 0.1 GO:0005412 glucose:sodium symporter activity(GO:0005412)
0.0 0.0 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.1 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.1 GO:0001758 retinal dehydrogenase activity(GO:0001758)
0.0 0.1 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0 0.1 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.0 0.1 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 0.1 GO:0004470 malic enzyme activity(GO:0004470)
0.0 0.1 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.1 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656) peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.0 0.1 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.1 GO:0015057 thrombin receptor activity(GO:0015057)
0.0 0.1 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 0.1 GO:0043495 protein anchor(GO:0043495)
0.0 0.4 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 0.1 GO:0043515 kinetochore binding(GO:0043515)
0.0 0.1 GO:0070548 L-glutamine aminotransferase activity(GO:0070548)
0.0 0.1 GO:0005114 type II transforming growth factor beta receptor binding(GO:0005114)
0.0 0.0 GO:0044020 histone methyltransferase activity (H4-R3 specific)(GO:0044020)
0.0 0.1 GO:0004568 chitinase activity(GO:0004568)
0.0 0.1 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.0 0.1 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 0.0 GO:0042808 obsolete neuronal Cdc2-like kinase binding(GO:0042808)
0.0 0.0 GO:0070052 collagen V binding(GO:0070052)
0.0 0.1 GO:0016565 obsolete general transcriptional repressor activity(GO:0016565)
0.0 0.1 GO:0005522 profilin binding(GO:0005522)
0.0 0.0 GO:0005350 pyrimidine nucleobase transmembrane transporter activity(GO:0005350)
0.0 0.1 GO:0042166 acetylcholine binding(GO:0042166)
0.0 0.0 GO:0003896 DNA primase activity(GO:0003896)
0.0 0.3 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 0.1 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.0 0.1 GO:0044548 S100 protein binding(GO:0044548)
0.0 0.1 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.0 0.2 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.0 GO:0004924 oncostatin-M receptor activity(GO:0004924)
0.0 0.0 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.0 0.1 GO:0008649 rRNA methyltransferase activity(GO:0008649)
0.0 0.1 GO:0030020 extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.0 0.1 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 0.1 GO:0005000 vasopressin receptor activity(GO:0005000)
0.0 0.1 GO:0070579 methylcytosine dioxygenase activity(GO:0070579)
0.0 0.1 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0 0.0 GO:0031708 bombesin receptor binding(GO:0031705) endothelin B receptor binding(GO:0031708)
0.0 0.1 GO:0043274 phospholipase binding(GO:0043274)
0.0 0.1 GO:0098988 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640) G-protein coupled glutamate receptor activity(GO:0098988)
0.0 0.1 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.0 0.2 GO:0005003 ephrin receptor activity(GO:0005003)
0.0 0.0 GO:0004103 choline kinase activity(GO:0004103)
0.0 0.0 GO:0030284 estrogen receptor activity(GO:0030284)
0.0 0.0 GO:0004849 uridine kinase activity(GO:0004849)
0.0 0.1 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.0 0.0 GO:0004142 diacylglycerol cholinephosphotransferase activity(GO:0004142)
0.0 0.0 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
0.0 0.1 GO:0045502 dynein binding(GO:0045502)
0.0 0.0 GO:0019211 phosphatase activator activity(GO:0019211)
0.0 0.1 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 0.1 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.0 PID INSULIN PATHWAY Insulin Pathway
0.0 0.0 PID TXA2PATHWAY Thromboxane A2 receptor signaling
0.0 0.6 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 0.1 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.0 0.0 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.0 0.3 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.0 0.0 PID PI3K PLC TRK PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.0 0.1 PID NETRIN PATHWAY Netrin-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.0 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.0 0.0 REACTOME FRS2 MEDIATED CASCADE Genes involved in FRS2-mediated cascade
0.0 0.3 REACTOME SEMA3A PAK DEPENDENT AXON REPULSION Genes involved in Sema3A PAK dependent Axon repulsion
0.0 0.0 REACTOME CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION Genes involved in Cleavage of Growing Transcript in the Termination Region
0.0 0.4 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 0.1 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.0 0.2 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.2 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 0.0 REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB Genes involved in PKA-mediated phosphorylation of CREB
0.0 0.3 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 0.1 REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.0 0.1 REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.0 0.0 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.0 0.1 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 0.1 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex