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ENCODE: H3K4me1 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for REST

Z-value: 1.41

Motif logo

Transcription factors associated with REST

Gene Symbol	Gene ID	Gene Info
REST Ensembl NCBI GeneCards UniProt	ENSG00000084093.11	REST

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
REST	chr4_57777906_57778057	3906	0.227338	0.85	3.9e-03	Click!
REST	chr4_57778173_57778407	4215	0.221384	0.84	4.3e-03	Click!
REST	chr4_57779546_57779697	5546	0.205075	0.84	4.8e-03	Click!
REST	chr4_57772726_57772877	1274	0.462181	0.79	1.2e-02	Click!
REST	chr4_57780484_57780729	6531	0.198074	0.76	1.7e-02	Click!

Activity of the REST motif across conditions

Conditions sorted by the z-value of the REST motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr2_16105641_16106067	1.20	ENSG00000243541	.	14751	0.18
chr16_12629710_12629861	1.09	RP11-552C15.1		9554	0.21
chr4_170745007_170745217	1.07	ENSG00000264713	.	38681	0.18
chr19_41812316_41812501	1.05	CCDC97	coiled-coil domain containing 97	3686	0.14
chr1_226839240_226839391	1.04	ITPKB-IT1	ITPKB intronic transcript 1 (non-protein coding)	8056	0.22
chr17_7238988_7239233	1.03	ACAP1	ArfGAP with coiled-coil, ankyrin repeat and PH domains 1	738	0.35
chr1_167403849_167404021	1.03	RP11-104L21.2		23963	0.18
chr14_99650324_99650558	0.99	AL162151.4		25688	0.22
chr17_47872778_47872961	0.99	KAT7	K(lysine) acetyltransferase 7	5854	0.16
chrX_71998101_71998349	0.99	FAM226B	family with sequence similarity 226, member B (non-protein coding)	793	0.49
chrX_72162146_72162394	0.98	RP11-493K23.1		60425	0.1
chrX_19769076_19769424	0.97	SH3KBP1	SH3-domain kinase binding protein 1	3429	0.37
chr11_47294314_47294656	0.92	MADD	MAP-kinase activating death domain	690	0.4
chr16_57077514_57077665	0.89	NLRC5	NLR family, CARD domain containing 5	14388	0.13
chr9_92064787_92064938	0.85	SEMA4D	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D	6006	0.26
chr5_169068270_169068510	0.80	DOCK2	dedicator of cytokinesis 2	4139	0.29
chr22_19566523_19566737	0.74	CLDN5	claudin 5	51562	0.11
chr10_6755732_6755883	0.73	PRKCQ	protein kinase C, theta	133544	0.05
chr6_159136937_159137205	0.73	ENSG00000265558	.	48714	0.12
chr19_41813754_41814061	0.71	CCDC97	coiled-coil domain containing 97	2187	0.19
chr16_23985615_23985766	0.66	PRKCB	protein kinase C, beta	137146	0.05
chr12_54369016_54369167	0.65	HOTAIR	HOX transcript antisense RNA	351	0.65
chr1_210111084_210111235	0.65	SYT14	synaptotagmin XIV	379	0.91
chr20_61612872_61613297	0.64	BHLHE23	basic helix-loop-helix family, member e23	25303	0.13
chr15_38831010_38831161	0.62	ENSG00000201509	.	3359	0.22
chr5_118673350_118673800	0.62	TNFAIP8	tumor necrosis factor, alpha-induced protein 8	4705	0.24
chr1_114697600_114697902	0.61	SYT6	synaptotagmin VI	1210	0.61
chr2_242830989_242831273	0.60	AC131097.3		7032	0.13
chr22_50468372_50468544	0.60	IL17REL	interleukin 17 receptor E-like	17370	0.14
chr17_74015416_74015567	0.60	EVPL	envoplakin	7821	0.11
chr7_55594594_55594826	0.59	VOPP1	vesicular, overexpressed in cancer, prosurvival protein 1	5	0.98
chr12_67878241_67878582	0.56	DYRK2	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2	163707	0.04
chr22_47165728_47165879	0.56	TBC1D22A	TBC1 domain family, member 22A	4021	0.22
chr1_11533775_11533926	0.55	PTCHD2	patched domain containing 2	5445	0.27
chr1_160591638_160591879	0.55	SLAMF1	signaling lymphocytic activation molecule family member 1	25053	0.13
chr17_72353834_72354067	0.52	BTBD17	BTB (POZ) domain containing 17	4135	0.13
chrX_118125991_118126142	0.52	LONRF3	LON peptidase N-terminal domain and ring finger 3	15771	0.27
chr2_225904625_225905195	0.52	DOCK10	dedicator of cytokinesis 10	2249	0.4
chrX_10051400_10051551	0.51	WWC3	WWC family member 3	19976	0.17
chr9_90219502_90219653	0.51	DAPK1-IT1	DAPK1 intronic transcript 1 (non-protein coding)	51208	0.15
chr14_74904478_74904629	0.50	SYNDIG1L	synapse differentiation inducing 1-like	11748	0.16
chr1_31655143_31655401	0.50	NKAIN1	Na+/K+ transporting ATPase interacting 1	5728	0.26
chr2_233962855_233963143	0.50	INPP5D	inositol polyphosphate-5-phosphatase, 145kDa	37810	0.15
chr2_109964621_109965051	0.48	ENSG00000265965	.	34755	0.23
chr19_2241635_2241786	0.48	SF3A2	splicing factor 3a, subunit 2, 66kDa	3917	0.09
chr2_86958260_86958411	0.47	CHMP3	charged multivesicular body protein 3	10090	0.16
chr3_149531781_149532051	0.47	RNF13	ring finger protein 13	292	0.9
chr22_20068670_20069051	0.46	DGCR8	DGCR8 microprocessor complex subunit	768	0.4
chr2_87292569_87292728	0.45	PLGLB1	plasminogen-like B1	43673	0.18
chr16_17466317_17466468	0.45	XYLT1	xylosyltransferase I	98346	0.09
chr19_11592662_11592813	0.44	ELAVL3	ELAV like neuron-specific RNA binding protein 3	889	0.37
chr11_67184748_67185203	0.44	CARNS1	carnosine synthase 1	1418	0.17
chr2_28589409_28589636	0.43	FOSL2	FOS-like antigen 2	26147	0.15
chr18_57567287_57567438	0.42	PMAIP1	phorbol-12-myristate-13-acetate-induced protein 1	114	0.98
chr1_45185068_45185274	0.42	ENSG00000199377	.	2403	0.15
chr10_71105240_71105689	0.42	ENSG00000221774	.	17933	0.17
chr3_186769260_186769496	0.42	ST6GAL1	ST6 beta-galactosamide alpha-2,6-sialyltranferase 1	7847	0.25
chr22_21960363_21960532	0.41	YDJC	YdjC homolog (bacterial)	23878	0.08
chr12_111853066_111853220	0.41	SH2B3	SH2B adaptor protein 3	3001	0.25
chr17_15801096_15801247	0.41	ADORA2B	adenosine A2b receptor	47060	0.12
chr10_102476009_102476160	0.40	PAX2	paired box 2	29384	0.2
chr9_132552883_132553034	0.40	TOR1B	torsin family 1, member B (torsin B)	12474	0.14
chr22_19875196_19875392	0.40	GNB1L	guanine nucleotide binding protein (G protein), beta polypeptide 1-like	32832	0.11
chr11_114036462_114036692	0.40	ENSG00000221112	.	78926	0.09
chr1_27815065_27815346	0.40	WASF2	WAS protein family, member 2	1357	0.42
chr16_17260014_17260165	0.39	CTD-2576D5.4		31728	0.26
chr17_45730012_45730165	0.39	KPNB1	karyopherin (importin) beta 1	1526	0.29
chr5_133447025_133447477	0.39	TCF7	transcription factor 7 (T-cell specific, HMG-box)	3151	0.29
chr10_25215654_25215805	0.39	ENSG00000240294	.	17988	0.2
chr11_64809018_64809233	0.38	SAC3D1	SAC3 domain containing 1	408	0.65
chr19_2275078_2275262	0.38	OAZ1	ornithine decarboxylase antizyme 1	4880	0.09
chr22_50627182_50627333	0.38	TRABD	TraB domain containing	1770	0.17
chr1_159906036_159906293	0.37	IGSF9	immunoglobulin superfamily, member 9	9222	0.1
chr9_92097148_92097521	0.37	SEMA4D	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D	2529	0.33
chr3_176905393_176905544	0.37	TBL1XR1	transducin (beta)-like 1 X-linked receptor 1	8743	0.26
chr1_10816631_10816782	0.35	CASZ1	castor zinc finger 1	39999	0.17
chr11_73093518_73093669	0.35	RELT	RELT tumor necrosis factor receptor	5880	0.15
chr17_72848624_72848775	0.35	GRIN2C	glutamate receptor, ionotropic, N-methyl D-aspartate 2C	7299	0.12
chr7_44086804_44086994	0.34	DBNL	drebrin-like	2580	0.14
chr6_42313847_42314001	0.34	ENSG00000221252	.	66210	0.1
chr2_136814753_136815076	0.34	AC093391.2		44879	0.15
chr11_72323822_72323973	0.34	ENSG00000272036	.	2277	0.2
chr7_150639904_150640066	0.33	KCNH2	potassium voltage-gated channel, subfamily H (eag-related), member 2	13009	0.15
chr11_114086673_114087539	0.33	NNMT	nicotinamide N-methyltransferase	41447	0.17
chr11_72387992_72388143	0.33	PDE2A	phosphodiesterase 2A, cGMP-stimulated	2570	0.17
chr3_71128590_71128951	0.32	FOXP1	forkhead box P1	13852	0.3
chr16_67219149_67219437	0.32	KIAA0895L	KIAA0895-like	1350	0.18
chr17_80372582_80372867	0.31	OGFOD3	2-oxoglutarate and iron-dependent oxygenase domain containing 3	668	0.47
chr7_5820337_5820488	0.31	RNF216	ring finger protein 216	839	0.62
chr18_74856849_74857000	0.31	MBP	myelin basic protein	12124	0.29
chr2_127729076_127729227	0.31	ENSG00000238788	.	45846	0.17
chr20_61641003_61641255	0.30	BHLHE23	basic helix-loop-helix family, member e23	2742	0.26
chr16_70147307_70147458	0.29	PDPR	pyruvate dehydrogenase phosphatase regulatory subunit	147	0.95
chr1_1951067_1951218	0.28	GABRD	gamma-aminobutyric acid (GABA) A receptor, delta	362	0.8
chr7_63387146_63387824	0.28	ENSG00000265017	.	271	0.93
chr12_65063443_65063668	0.28	RP11-338E21.3		14756	0.13
chr2_128398319_128398483	0.27	LIMS2	LIM and senescent cell antigen-like domains 2	1305	0.36
chr8_27166583_27166786	0.27	TRIM35	tripartite motif containing 35	2071	0.29
chr1_202597377_202597570	0.26	SYT2	synaptotagmin II	15108	0.19
chr5_1386958_1387109	0.26	SLC6A3	solute carrier family 6 (neurotransmitter transporter), member 3	14389	0.2
chr2_127835468_127835835	0.26	BIN1	bridging integrator 1	28926	0.2
chr2_202897042_202897217	0.26	FZD7	frizzled family receptor 7	2181	0.29
chr2_200322076_200322268	0.25	SATB2-AS1	SATB2 antisense RNA 1	251	0.8
chr22_19594782_19594948	0.25	CLDN5	claudin 5	79797	0.07
chr2_8662865_8663263	0.25	AC011747.7		152832	0.04
chr21_35749595_35749755	0.25	SMIM11	small integral membrane protein 11	1772	0.24
chr16_10977059_10977210	0.25	CIITA	class II, major histocompatibility complex, transactivator	4308	0.17
chr15_75287610_75287761	0.25	SCAMP5	secretory carrier membrane protein 5	188	0.92
chr19_14106857_14107008	0.25	RFX1	regulatory factor X, 1 (influences HLA class II expression)	10142	0.1
chr17_30832201_30832435	0.24	RP11-466A19.1		9764	0.11
chr10_50970365_50970516	0.24	OGDHL	oxoglutarate dehydrogenase-like	15	0.99
chr19_34710303_34710454	0.24	KIAA0355	KIAA0355	35064	0.17
chr2_176969721_176969887	0.24	HOXD11	homeobox D11	2210	0.13
chr22_22723942_22724093	0.24	IGLV7-46	immunoglobulin lambda variable 7-46 (gene/pseudogene)	35	0.92
chr11_10645276_10645517	0.24	MRVI1	murine retrovirus integration site 1 homolog	28336	0.14
chr12_68575235_68575386	0.24	IFNG	interferon, gamma	21783	0.21
chr3_192231846_192231997	0.24	FGF12-AS2	FGF12 antisense RNA 2	890	0.57
chr15_99792838_99792989	0.24	LRRC28	leucine rich repeat containing 28	897	0.45
chr22_32547515_32547829	0.24	C22orf42	chromosome 22 open reading frame 42	7603	0.15
chr12_8392979_8393130	0.23	FAM86FP	family with sequence similarity 86, member F, pseudogene	2490	0.2
chr20_61372891_61373540	0.23	RP11-93B14.4		6516	0.13
chr20_30556161_30556387	0.23	XKR7	XK, Kell blood group complex subunit-related family, member 7	469	0.74
chr8_128683180_128683331	0.23	MYC	v-myc avian myelocytomatosis viral oncogene homolog	64425	0.14
chr14_75721640_75721882	0.23	RP11-293M10.2		4353	0.18
chr6_15422306_15422566	0.23	JARID2	jumonji, AT rich interactive domain 2	21347	0.24
chr3_128714434_128714585	0.22	KIAA1257	KIAA1257	1551	0.32
chr21_46325123_46325274	0.22	ITGB2	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)	5347	0.12
chr17_7164242_7164414	0.22	CLDN7	claudin 7	136	0.86
chr16_67511839_67511990	0.22	ATP6V0D1	ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1	3068	0.13
chr3_49907414_49907654	0.22	CAMKV	CaM kinase-like vesicle-associated	121	0.92
chr10_102758190_102758435	0.22	LZTS2	leucine zipper, putative tumor suppressor 2	132	0.92
chr7_102072492_102072712	0.21	ORAI2	ORAI calcium release-activated calcium modulator 2	951	0.34
chr1_42340544_42340695	0.21	HIVEP3	human immunodeficiency virus type I enhancer binding protein 3	43550	0.19
chr7_100452199_100452350	0.21	SLC12A9	solute carrier family 12, member 9	1366	0.23
chr2_69824424_69824747	0.21	AAK1	AP2 associated kinase 1	46201	0.13
chr1_21985717_21985868	0.21	RAP1GAP	RAP1 GTPase activating protein	5992	0.22
chr14_24906150_24906982	0.20	SDR39U1	short chain dehydrogenase/reductase family 39U, member 1	3691	0.13
chr4_185151337_185151488	0.20	ENPP6	ectonucleotide pyrophosphatase/phosphodiesterase 6	9029	0.22
chr16_30663214_30663498	0.20	PRR14	proline rich 14	845	0.38
chr6_128116207_128116358	0.20	THEMIS	thymocyte selection associated	105821	0.07
chr2_87088838_87088989	0.20	AC111200.1		110	0.52
chr9_134158483_134158787	0.20	PPAPDC3	phosphatidic acid phosphatase type 2 domain containing 3	6446	0.19
chr11_130030979_130031130	0.20	ST14	suppression of tumorigenicity 14 (colon carcinoma)	1597	0.48
chr20_62327781_62327932	0.20	TNFRSF6B	tumor necrosis factor receptor superfamily, member 6b, decoy	165	0.89
chr20_32063520_32063671	0.20	CBFA2T2	core-binding factor, runt domain, alpha subunit 2; translocated to, 2	14298	0.16
chr20_44562270_44562484	0.20	PCIF1	PDX1 C-terminal inhibiting factor 1	890	0.41
chr22_39101161_39101408	0.19	GTPBP1	GTP binding protein 1	444	0.63
chr17_76894600_76894751	0.19	DDC8	Protein DDC8 homolog	4608	0.16
chr15_81073049_81073200	0.19	KIAA1199	KIAA1199	1412	0.48
chr17_4837349_4837633	0.19	GP1BA	glycoprotein Ib (platelet), alpha polypeptide	1899	0.13
chr1_65015285_65015436	0.19	ENSG00000264470	.	30170	0.22
chr10_27393964_27394336	0.19	ANKRD26	ankyrin repeat domain 26	4729	0.19
chr7_43648853_43649004	0.19	STK17A	serine/threonine kinase 17a	26264	0.16
chr1_1196273_1196468	0.18	UBE2J2	ubiquitin-conjugating enzyme E2, J2	5133	0.08
chrX_54666603_54666913	0.18	GNL3L	guanine nucleotide binding protein-like 3 (nucleolar)-like	110083	0.06
chr7_100807784_100807964	0.18	VGF	VGF nerve growth factor inducible	521	0.62
chr12_113525124_113525488	0.18	DTX1	deltex homolog 1 (Drosophila)	29811	0.12
chr18_13389567_13389718	0.18	LDLRAD4	low density lipoprotein receptor class A domain containing 4	7089	0.16
chr11_116658070_116658327	0.18	ZNF259	zinc finger protein 259	497	0.66
chr6_37492858_37493009	0.18	CCDC167	coiled-coil domain containing 167	25235	0.17
chr1_19792513_19792785	0.18	CAPZB	capping protein (actin filament) muscle Z-line, beta	17930	0.15
chr4_2413440_2413605	0.18	ZFYVE28	zinc finger, FYVE domain containing 28	5130	0.2
chr6_11710027_11710178	0.17	ENSG00000207419	.	50	0.98
chr4_114711563_114711838	0.17	CAMK2D	calcium/calmodulin-dependent protein kinase II delta	28617	0.25
chr6_71403946_71404097	0.17	SMAP1	small ArfGAP 1	26400	0.25
chr1_6116555_6116706	0.17	KCNAB2	potassium voltage-gated channel, shaker-related subfamily, beta member 2	10456	0.17
chr20_22982685_22982836	0.17	RP4-753D10.5		28662	0.14
chr22_48594558_48594851	0.17	ENSG00000266508	.	75472	0.13
chr17_2907221_2907372	0.17	CTD-3060P21.1		38107	0.15
chr2_71577502_71577653	0.17	ZNF638	zinc finger protein 638	14982	0.21
chr19_4173171_4173322	0.16	SIRT6	sirtuin 6	9030	0.11
chr17_7217900_7218108	0.16	GPS2	G protein pathway suppressor 2	438	0.57
chr17_2728637_2728798	0.16	RAP1GAP2	RAP1 GTPase activating protein 2	28941	0.16
chr22_20254654_20254883	0.16	RTN4R	reticulon 4 receptor	444	0.76
chr2_75068651_75069070	0.16	HK2	hexokinase 2	6563	0.27
chr1_160596062_160596341	0.16	SLAMF1	signaling lymphocytic activation molecule family member 1	20610	0.14
chr14_105532458_105532739	0.15	GPR132	G protein-coupled receptor 132	816	0.63
chr15_100880792_100881029	0.15	ADAMTS17	ADAM metallopeptidase with thrombospondin type 1 motif, 17	431	0.87
chr8_1430433_1430590	0.15	DLGAP2	discs, large (Drosophila) homolog-associated protein 2	19021	0.28
chr12_123463756_123463907	0.15	ARL6IP4	ADP-ribosylation-like factor 6 interacting protein 4	776	0.47
chr19_1880685_1880847	0.15	ABHD17A	abhydrolase domain containing 17A	818	0.41
chr16_86017398_86017670	0.15	IRF8	interferon regulatory factor 8	69615	0.12
chr16_89486022_89486173	0.15	RP1-168P16.1		2537	0.2
chr2_8630425_8630719	0.14	AC011747.7		185324	0.03
chr2_128391549_128391703	0.14	RP11-286H15.1		7203	0.14
chr17_71593303_71593454	0.14	RP11-277J6.2		43787	0.15
chr11_27721228_27721573	0.14	BDNF	brain-derived neurotrophic factor	186	0.96
chr6_158990244_158990658	0.14	TMEM181	transmembrane protein 181	32983	0.16
chr3_52306854_52307095	0.14	ENSG00000199150	.	4595	0.1
chr16_69500758_69500909	0.14	CYB5B	cytochrome b5 type B (outer mitochondrial membrane)	42147	0.12
chr12_62859890_62860041	0.14	MON2	MON2 homolog (S. cerevisiae)	632	0.74
chr19_34973449_34973600	0.14	WTIP	Wilms tumor 1 interacting protein	91	0.96
chr17_70716063_70716406	0.14	ENSG00000222545	.	5624	0.27
chr2_230579828_230580138	0.14	DNER	delta/notch-like EGF repeat containing	709	0.76
chr1_6074601_6074752	0.14	KCNAB2	potassium voltage-gated channel, shaker-related subfamily, beta member 2	11684	0.17
chr3_59940204_59940355	0.14	NPCDR1	nasopharyngeal carcinoma, down-regulated 1	17304	0.31
chr5_131813246_131813397	0.14	AC116366.6		4586	0.15
chr16_79446696_79446975	0.13	ENSG00000222244	.	148484	0.04
chr4_8231570_8231721	0.13	SH3TC1	SH3 domain and tetratricopeptide repeats 1	10926	0.22
chr2_239192445_239192596	0.13	AC012485.1	Uncharacterized protein	191	0.91

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of REST

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0042149	cellular response to glucose starvation(GO:0042149)
0.1	0.2	GO:0031580	membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.1	0.1	GO:0019049	evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.1	0.2	GO:0045343	MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343)
0.0	0.3	GO:0006546	glycine catabolic process(GO:0006546)
0.0	0.2	GO:0031053	primary miRNA processing(GO:0031053)
0.0	0.2	GO:0046668	regulation of retinal cell programmed cell death(GO:0046668)
0.0	0.2	GO:0045956	positive regulation of calcium ion-dependent exocytosis(GO:0045956)
0.0	0.1	GO:0019987	obsolete negative regulation of anti-apoptosis(GO:0019987)
0.0	0.1	GO:2001012	mesenchymal cell differentiation involved in kidney development(GO:0072161) metanephric mesenchymal cell differentiation(GO:0072162) mesenchymal cell differentiation involved in renal system development(GO:2001012)
0.0	0.1	GO:0070670	response to interleukin-4(GO:0070670)
0.0	0.1	GO:2000696	nephron tubule epithelial cell differentiation(GO:0072160) regulation of nephron tubule epithelial cell differentiation(GO:0072182) regulation of epithelial cell differentiation involved in kidney development(GO:2000696)
0.0	0.1	GO:0001705	ectoderm formation(GO:0001705)
0.0	0.1	GO:0033152	immunoglobulin V(D)J recombination(GO:0033152)
0.0	0.2	GO:0051085	chaperone mediated protein folding requiring cofactor(GO:0051085)
0.0	0.1	GO:0030223	neutrophil differentiation(GO:0030223)
0.0	0.1	GO:0031282	regulation of guanylate cyclase activity(GO:0031282)
0.0	0.1	GO:0046877	regulation of saliva secretion(GO:0046877)
0.0	0.1	GO:0006610	ribosomal protein import into nucleus(GO:0006610)
0.0	0.1	GO:0071698	olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.0	0.0	GO:0010831	positive regulation of myotube differentiation(GO:0010831)
0.0	0.1	GO:0001880	Mullerian duct regression(GO:0001880)
0.0	0.1	GO:0043320	natural killer cell activation involved in immune response(GO:0002323) natural killer cell degranulation(GO:0043320)
0.0	0.1	GO:0035162	embryonic hemopoiesis(GO:0035162)
0.0	0.0	GO:0060435	bronchiole development(GO:0060435)
0.0	0.4	GO:0051865	protein autoubiquitination(GO:0051865)
0.0	0.0	GO:0072216	positive regulation of metanephros development(GO:0072216)
0.0	0.0	GO:0030952	establishment or maintenance of cytoskeleton polarity(GO:0030952)
0.0	0.1	GO:0045059	positive thymic T cell selection(GO:0045059)
0.0	0.0	GO:0000103	sulfate assimilation(GO:0000103)
0.0	0.1	GO:0033962	cytoplasmic mRNA processing body assembly(GO:0033962)
0.0	0.0	GO:0043368	positive T cell selection(GO:0043368)
0.0	0.1	GO:0051708	intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) regulation by virus of viral protein levels in host cell(GO:0046719) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708)
0.0	0.1	GO:0051570	regulation of histone H3-K9 methylation(GO:0051570)
0.0	0.0	GO:0016080	synaptic vesicle targeting(GO:0016080)
0.0	0.0	GO:0018094	protein polyglycylation(GO:0018094)
0.0	0.0	GO:0045163	clustering of voltage-gated potassium channels(GO:0045163)
0.0	0.3	GO:0016338	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.0	0.1	GO:0035195	gene silencing by miRNA(GO:0035195)
0.0	0.0	GO:0034219	carbohydrate transmembrane transport(GO:0034219)
0.0	0.0	GO:0051176	positive regulation of sulfur metabolic process(GO:0051176)
0.0	0.1	GO:0045651	positive regulation of macrophage differentiation(GO:0045651)
0.0	0.1	GO:0051491	positive regulation of filopodium assembly(GO:0051491)
0.0	0.2	GO:0050691	regulation of defense response to virus by host(GO:0050691)
0.0	0.0	GO:0009405	pathogenesis(GO:0009405)
0.0	0.1	GO:0006896	Golgi to endosome transport(GO:0006895) Golgi to vacuole transport(GO:0006896)
0.0	0.1	GO:0014009	glial cell proliferation(GO:0014009)
0.0	0.0	GO:0045901	translational frameshifting(GO:0006452) positive regulation of translational elongation(GO:0045901) positive regulation of translational termination(GO:0045905)
0.0	0.1	GO:0032464	positive regulation of protein homooligomerization(GO:0032464)
0.0	0.1	GO:0048741	skeletal muscle fiber development(GO:0048741)
0.0	0.0	GO:0048388	endosomal lumen acidification(GO:0048388)
0.0	0.1	GO:0043084	penile erection(GO:0043084)
0.0	0.0	GO:0035405	histone-threonine phosphorylation(GO:0035405)
0.0	0.0	GO:0045006	DNA deamination(GO:0045006)

Gene overrepresentation in cellular component category:

Total log-likelihood	Term	Description
0.2	GO:0032588	trans-Golgi network membrane(GO:0032588)
0.1	GO:0043218	compact myelin(GO:0043218)
0.1	GO:0042105	alpha-beta T cell receptor complex(GO:0042105)
0.1	GO:0044224	juxtaparanode region of axon(GO:0044224)
0.1	GO:0034451	centriolar satellite(GO:0034451)
0.2	GO:0042101	T cell receptor complex(GO:0042101)
0.5	GO:0005637	nuclear inner membrane(GO:0005637)
0.1	GO:0005947	mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947)
0.0	GO:0070188	obsolete Stn1-Ten1 complex(GO:0070188)
0.0	GO:0042584	chromaffin granule(GO:0042583) chromaffin granule membrane(GO:0042584)
0.0	GO:0005954	calcium- and calmodulin-dependent protein kinase complex(GO:0005954)
0.0	GO:0016533	cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.1	GO:0008274	gamma-tubulin large complex(GO:0000931) gamma-tubulin ring complex(GO:0008274)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0017112	Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.1	0.2	GO:0004591	oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.1	0.2	GO:0042608	T cell receptor binding(GO:0042608)
0.1	0.3	GO:0004047	aminomethyltransferase activity(GO:0004047)
0.0	0.1	GO:0004340	glucokinase activity(GO:0004340)
0.0	0.2	GO:0008158	hedgehog receptor activity(GO:0008158)
0.0	0.1	GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.0	0.1	GO:0045499	chemorepellent activity(GO:0045499)
0.0	0.1	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977) RNA polymerase II regulatory region DNA binding(GO:0001012)
0.0	0.1	GO:0004176	ATP-dependent peptidase activity(GO:0004176)
0.0	0.1	GO:0005114	type II transforming growth factor beta receptor binding(GO:0005114)
0.0	0.1	GO:0004308	exo-alpha-sialidase activity(GO:0004308) alpha-sialidase activity(GO:0016997)
0.0	0.0	GO:0016286	small conductance calcium-activated potassium channel activity(GO:0016286)
0.0	0.1	GO:0019911	structural constituent of myelin sheath(GO:0019911)
0.0	0.2	GO:0017091	AU-rich element binding(GO:0017091)
0.0	0.1	GO:0008073	ornithine decarboxylase inhibitor activity(GO:0008073)
0.0	0.0	GO:0004966	galanin receptor activity(GO:0004966)
0.0	0.1	GO:0005112	Notch binding(GO:0005112)
0.0	0.1	GO:0008967	phosphoglycolate phosphatase activity(GO:0008967)
0.0	0.2	GO:0042288	MHC class I protein binding(GO:0042288)
0.0	0.0	GO:0070735	protein-glycine ligase activity(GO:0070735)
0.0	0.1	GO:0008139	nuclear localization sequence binding(GO:0008139)
0.0	0.2	GO:0004890	GABA-A receptor activity(GO:0004890)
0.0	0.0	GO:0008401	retinoic acid 4-hydroxylase activity(GO:0008401)
0.0	0.0	GO:0050220	prostaglandin-E synthase activity(GO:0050220)
0.0	0.1	GO:0016624	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor(GO:0016624)
0.0	0.1	GO:0017070	U6 snRNA binding(GO:0017070)
0.0	0.0	GO:0042285	UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285)
0.0	0.0	GO:0055077	gap junction hemi-channel activity(GO:0055077)
0.0	0.1	GO:0001727	lipid kinase activity(GO:0001727)
0.0	0.0	GO:0004396	hexokinase activity(GO:0004396)
0.0	0.4	GO:0004629	phospholipase C activity(GO:0004629)
0.0	0.0	GO:0004995	tachykinin receptor activity(GO:0004995)
0.0	0.0	GO:0005047	signal recognition particle binding(GO:0005047)
0.0	0.0	GO:0035184	histone threonine kinase activity(GO:0035184)
0.0	0.1	GO:0005095	GTPase inhibitor activity(GO:0005095)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.2	PID AR TF PATHWAY	Regulation of Androgen receptor activity
0.4	PID ARF6 PATHWAY	Arf6 signaling events
0.3	PID IL8 CXCR2 PATHWAY	IL8- and CXCR2-mediated signaling events
0.1	ST PAC1 RECEPTOR PATHWAY	PAC1 Receptor Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.4	REACTOME ACTIVATION OF BH3 ONLY PROTEINS	Genes involved in Activation of BH3-only proteins
0.3	REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.3	REACTOME EGFR DOWNREGULATION	Genes involved in EGFR downregulation
0.0	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.4	REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS	Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.1	REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.3	REACTOME TIGHT JUNCTION INTERACTIONS	Genes involved in Tight junction interactions
0.2	REACTOME MICRORNA MIRNA BIOGENESIS	Genes involved in MicroRNA (miRNA) Biogenesis