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ENCODE: H3K4me1 ChIP-Seq of primary human cells
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Results for REST

Z-value: 1.41

Motif logo

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Transcription factors associated with REST

Gene Symbol Gene ID Gene Info
REST
ENSG00000084093.11 RE1 silencing transcription factor

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr4_57777906_57778057REST39060.2273380.853.9e-03Click!
chr4_57778173_57778407REST42150.2213840.844.3e-03Click!
chr4_57779546_57779697REST55460.2050750.844.8e-03Click!
chr4_57772726_57772877REST12740.4621810.791.2e-02Click!
chr4_57780484_57780729REST65310.1980740.761.7e-02Click!

Activity of the REST motif across conditions

Conditions sorted by the z-value of the REST motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr2_16105641_16106067 1.20 ENSG00000243541
 .
 14751
 0.18
chr16_12629710_12629861 1.09 RP11-552C15.1
9554
 0.21
chr4_170745007_170745217 1.07 ENSG00000264713
 .
 38681
 0.18
chr19_41812316_41812501 1.05 CCDC97
 coiled-coil domain containing 97
 3686
 0.14
chr1_226839240_226839391 1.04 ITPKB-IT1
 ITPKB intronic transcript 1 (non-protein coding)
 8056
 0.22
chr17_7238988_7239233 1.03 ACAP1
 ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
 738
 0.35
chr1_167403849_167404021 1.03 RP11-104L21.2
23963
 0.18
chr14_99650324_99650558 0.99 AL162151.4
25688
 0.22
chr17_47872778_47872961 0.99 KAT7
 K(lysine) acetyltransferase 7
 5854
 0.16
chrX_71998101_71998349 0.99 FAM226B
 family with sequence similarity 226, member B (non-protein coding)
 793
 0.49
chrX_72162146_72162394 0.98 RP11-493K23.1
60425
 0.1
chrX_19769076_19769424 0.97 SH3KBP1
 SH3-domain kinase binding protein 1
 3429
 0.37
chr11_47294314_47294656 0.92 MADD
 MAP-kinase activating death domain
 690
 0.4
chr16_57077514_57077665 0.89 NLRC5
 NLR family, CARD domain containing 5
 14388
 0.13
chr9_92064787_92064938 0.85 SEMA4D
 sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
 6006
 0.26
chr5_169068270_169068510 0.80 DOCK2
 dedicator of cytokinesis 2
 4139
 0.29
chr22_19566523_19566737 0.74 CLDN5
 claudin 5
 51562
 0.11
chr10_6755732_6755883 0.73 PRKCQ
 protein kinase C, theta
 133544
 0.05
chr6_159136937_159137205 0.73 ENSG00000265558
 .
 48714
 0.12
chr19_41813754_41814061 0.71 CCDC97
 coiled-coil domain containing 97
 2187
 0.19
chr16_23985615_23985766 0.66 PRKCB
 protein kinase C, beta
 137146
 0.05
chr12_54369016_54369167 0.65 HOTAIR
 HOX transcript antisense RNA
 351
 0.65
chr1_210111084_210111235 0.65 SYT14
 synaptotagmin XIV
 379
 0.91
chr20_61612872_61613297 0.64 BHLHE23
 basic helix-loop-helix family, member e23
 25303
 0.13
chr15_38831010_38831161 0.62 ENSG00000201509
 .
 3359
 0.22
chr5_118673350_118673800 0.62 TNFAIP8
 tumor necrosis factor, alpha-induced protein 8
 4705
 0.24
chr1_114697600_114697902 0.61 SYT6
 synaptotagmin VI
 1210
 0.61
chr2_242830989_242831273 0.60 AC131097.3
7032
 0.13
chr22_50468372_50468544 0.60 IL17REL
 interleukin 17 receptor E-like
 17370
 0.14
chr17_74015416_74015567 0.60 EVPL
 envoplakin
 7821
 0.11
chr7_55594594_55594826 0.59 VOPP1
 vesicular, overexpressed in cancer, prosurvival protein 1
 5
 0.98
chr12_67878241_67878582 0.56 DYRK2
 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
 163707
 0.04
chr22_47165728_47165879 0.56 TBC1D22A
 TBC1 domain family, member 22A
 4021
 0.22
chr1_11533775_11533926 0.55 PTCHD2
 patched domain containing 2
 5445
 0.27
chr1_160591638_160591879 0.55 SLAMF1
 signaling lymphocytic activation molecule family member 1
 25053
 0.13
chr17_72353834_72354067 0.52 BTBD17
 BTB (POZ) domain containing 17
 4135
 0.13
chrX_118125991_118126142 0.52 LONRF3
 LON peptidase N-terminal domain and ring finger 3
 15771
 0.27
chr2_225904625_225905195 0.52 DOCK10
 dedicator of cytokinesis 10
 2249
 0.4
chrX_10051400_10051551 0.51 WWC3
 WWC family member 3
 19976
 0.17
chr9_90219502_90219653 0.51 DAPK1-IT1
 DAPK1 intronic transcript 1 (non-protein coding)
 51208
 0.15
chr14_74904478_74904629 0.50 SYNDIG1L
 synapse differentiation inducing 1-like
 11748
 0.16
chr1_31655143_31655401 0.50 NKAIN1
 Na+/K+ transporting ATPase interacting 1
 5728
 0.26
chr2_233962855_233963143 0.50 INPP5D
 inositol polyphosphate-5-phosphatase, 145kDa
 37810
 0.15
chr2_109964621_109965051 0.48 ENSG00000265965
 .
 34755
 0.23
chr19_2241635_2241786 0.48 SF3A2
 splicing factor 3a, subunit 2, 66kDa
 3917
 0.09
chr2_86958260_86958411 0.47 CHMP3
 charged multivesicular body protein 3
 10090
 0.16
chr3_149531781_149532051 0.47 RNF13
 ring finger protein 13
 292
 0.9
chr22_20068670_20069051 0.46 DGCR8
 DGCR8 microprocessor complex subunit
 768
 0.4
chr2_87292569_87292728 0.45 PLGLB1
 plasminogen-like B1
 43673
 0.18
chr16_17466317_17466468 0.45 XYLT1
 xylosyltransferase I
 98346
 0.09
chr19_11592662_11592813 0.44 ELAVL3
 ELAV like neuron-specific RNA binding protein 3
 889
 0.37
chr11_67184748_67185203 0.44 CARNS1
 carnosine synthase 1
 1418
 0.17
chr2_28589409_28589636 0.43 FOSL2
 FOS-like antigen 2
 26147
 0.15
chr18_57567287_57567438 0.42 PMAIP1
 phorbol-12-myristate-13-acetate-induced protein 1
 114
 0.98
chr1_45185068_45185274 0.42 ENSG00000199377
 .
 2403
 0.15
chr10_71105240_71105689 0.42 ENSG00000221774
 .
 17933
 0.17
chr3_186769260_186769496 0.42 ST6GAL1
 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
 7847
 0.25
chr22_21960363_21960532 0.41 YDJC
 YdjC homolog (bacterial)
 23878
 0.08
chr12_111853066_111853220 0.41 SH2B3
 SH2B adaptor protein 3
 3001
 0.25
chr17_15801096_15801247 0.41 ADORA2B
 adenosine A2b receptor
 47060
 0.12
chr10_102476009_102476160 0.40 PAX2
 paired box 2
 29384
 0.2
chr9_132552883_132553034 0.40 TOR1B
 torsin family 1, member B (torsin B)
 12474
 0.14
chr22_19875196_19875392 0.40 GNB1L
 guanine nucleotide binding protein (G protein), beta polypeptide 1-like
 32832
 0.11
chr11_114036462_114036692 0.40 ENSG00000221112
 .
 78926
 0.09
chr1_27815065_27815346 0.40 WASF2
 WAS protein family, member 2
 1357
 0.42
chr16_17260014_17260165 0.39 CTD-2576D5.4
31728
 0.26
chr17_45730012_45730165 0.39 KPNB1
 karyopherin (importin) beta 1
 1526
 0.29
chr5_133447025_133447477 0.39 TCF7
 transcription factor 7 (T-cell specific, HMG-box)
 3151
 0.29
chr10_25215654_25215805 0.39 ENSG00000240294
 .
 17988
 0.2
chr11_64809018_64809233 0.38 SAC3D1
 SAC3 domain containing 1
 408
 0.65
chr19_2275078_2275262 0.38 OAZ1
 ornithine decarboxylase antizyme 1
 4880
 0.09
chr22_50627182_50627333 0.38 TRABD
 TraB domain containing
 1770
 0.17
chr1_159906036_159906293 0.37 IGSF9
 immunoglobulin superfamily, member 9
 9222
 0.1
chr9_92097148_92097521 0.37 SEMA4D
 sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
 2529
 0.33
chr3_176905393_176905544 0.37 TBL1XR1
 transducin (beta)-like 1 X-linked receptor 1
 8743
 0.26
chr1_10816631_10816782 0.35 CASZ1
 castor zinc finger 1
 39999
 0.17
chr11_73093518_73093669 0.35 RELT
 RELT tumor necrosis factor receptor
 5880
 0.15
chr17_72848624_72848775 0.35 GRIN2C
 glutamate receptor, ionotropic, N-methyl D-aspartate 2C
 7299
 0.12
chr7_44086804_44086994 0.34 DBNL
 drebrin-like
 2580
 0.14
chr6_42313847_42314001 0.34 ENSG00000221252
 .
 66210
 0.1
chr2_136814753_136815076 0.34 AC093391.2
44879
 0.15
chr11_72323822_72323973 0.34 ENSG00000272036
 .
 2277
 0.2
chr7_150639904_150640066 0.33 KCNH2
 potassium voltage-gated channel, subfamily H (eag-related), member 2
 13009
 0.15
chr11_114086673_114087539 0.33 NNMT
 nicotinamide N-methyltransferase
 41447
 0.17
chr11_72387992_72388143 0.33 PDE2A
 phosphodiesterase 2A, cGMP-stimulated
 2570
 0.17
chr3_71128590_71128951 0.32 FOXP1
 forkhead box P1
 13852
 0.3
chr16_67219149_67219437 0.32 KIAA0895L
 KIAA0895-like
 1350
 0.18
chr17_80372582_80372867 0.31 OGFOD3
 2-oxoglutarate and iron-dependent oxygenase domain containing 3
 668
 0.47
chr7_5820337_5820488 0.31 RNF216
 ring finger protein 216
 839
 0.62
chr18_74856849_74857000 0.31 MBP
 myelin basic protein
 12124
 0.29
chr2_127729076_127729227 0.31 ENSG00000238788
 .
 45846
 0.17
chr20_61641003_61641255 0.30 BHLHE23
 basic helix-loop-helix family, member e23
 2742
 0.26
chr16_70147307_70147458 0.29 PDPR
 pyruvate dehydrogenase phosphatase regulatory subunit
 147
 0.95
chr1_1951067_1951218 0.28 GABRD
 gamma-aminobutyric acid (GABA) A receptor, delta
 362
 0.8
chr7_63387146_63387824 0.28 ENSG00000265017
 .
 271
 0.93
chr12_65063443_65063668 0.28 RP11-338E21.3
14756
 0.13
chr2_128398319_128398483 0.27 LIMS2
 LIM and senescent cell antigen-like domains 2
 1305
 0.36
chr8_27166583_27166786 0.27 TRIM35
 tripartite motif containing 35
 2071
 0.29
chr1_202597377_202597570 0.26 SYT2
 synaptotagmin II
 15108
 0.19
chr5_1386958_1387109 0.26 SLC6A3
 solute carrier family 6 (neurotransmitter transporter), member 3
 14389
 0.2
chr2_127835468_127835835 0.26 BIN1
 bridging integrator 1
 28926
 0.2
chr2_202897042_202897217 0.26 FZD7
 frizzled family receptor 7
 2181
 0.29
chr2_200322076_200322268 0.25 SATB2-AS1
 SATB2 antisense RNA 1
 251
 0.8
chr22_19594782_19594948 0.25 CLDN5
 claudin 5
 79797
 0.07
chr2_8662865_8663263 0.25 AC011747.7
152832
 0.04
chr21_35749595_35749755 0.25 SMIM11
 small integral membrane protein 11
 1772
 0.24
chr16_10977059_10977210 0.25 CIITA
 class II, major histocompatibility complex, transactivator
 4308
 0.17
chr15_75287610_75287761 0.25 SCAMP5
 secretory carrier membrane protein 5
 188
 0.92
chr19_14106857_14107008 0.25 RFX1
 regulatory factor X, 1 (influences HLA class II expression)
 10142
 0.1
chr17_30832201_30832435 0.24 RP11-466A19.1
9764
 0.11
chr10_50970365_50970516 0.24 OGDHL
 oxoglutarate dehydrogenase-like
 15
 0.99
chr19_34710303_34710454 0.24 KIAA0355
 KIAA0355
 35064
 0.17
chr2_176969721_176969887 0.24 HOXD11
 homeobox D11
 2210
 0.13
chr22_22723942_22724093 0.24 IGLV7-46
 immunoglobulin lambda variable 7-46 (gene/pseudogene)
 35
 0.92
chr11_10645276_10645517 0.24 MRVI1
 murine retrovirus integration site 1 homolog
 28336
 0.14
chr12_68575235_68575386 0.24 IFNG
 interferon, gamma
 21783
 0.21
chr3_192231846_192231997 0.24 FGF12-AS2
 FGF12 antisense RNA 2
 890
 0.57
chr15_99792838_99792989 0.24 LRRC28
 leucine rich repeat containing 28
 897
 0.45
chr22_32547515_32547829 0.24 C22orf42
 chromosome 22 open reading frame 42
 7603
 0.15
chr12_8392979_8393130 0.23 FAM86FP
 family with sequence similarity 86, member F, pseudogene
 2490
 0.2
chr20_61372891_61373540 0.23 RP11-93B14.4
6516
 0.13
chr20_30556161_30556387 0.23 XKR7
 XK, Kell blood group complex subunit-related family, member 7
 469
 0.74
chr8_128683180_128683331 0.23 MYC
 v-myc avian myelocytomatosis viral oncogene homolog
 64425
 0.14
chr14_75721640_75721882 0.23 RP11-293M10.2
4353
 0.18
chr6_15422306_15422566 0.23 JARID2
 jumonji, AT rich interactive domain 2
 21347
 0.24
chr3_128714434_128714585 0.22 KIAA1257
 KIAA1257
 1551
 0.32
chr21_46325123_46325274 0.22 ITGB2
 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
 5347
 0.12
chr17_7164242_7164414 0.22 CLDN7
 claudin 7
 136
 0.86
chr16_67511839_67511990 0.22 ATP6V0D1
 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1
 3068
 0.13
chr3_49907414_49907654 0.22 CAMKV
 CaM kinase-like vesicle-associated
 121
 0.92
chr10_102758190_102758435 0.22 LZTS2
 leucine zipper, putative tumor suppressor 2
 132
 0.92
chr7_102072492_102072712 0.21 ORAI2
 ORAI calcium release-activated calcium modulator 2
 951
 0.34
chr1_42340544_42340695 0.21 HIVEP3
 human immunodeficiency virus type I enhancer binding protein 3
 43550
 0.19
chr7_100452199_100452350 0.21 SLC12A9
 solute carrier family 12, member 9
 1366
 0.23
chr2_69824424_69824747 0.21 AAK1
 AP2 associated kinase 1
 46201
 0.13
chr1_21985717_21985868 0.21 RAP1GAP
 RAP1 GTPase activating protein
 5992
 0.22
chr14_24906150_24906982 0.20 SDR39U1
 short chain dehydrogenase/reductase family 39U, member 1
 3691
 0.13
chr4_185151337_185151488 0.20 ENPP6
 ectonucleotide pyrophosphatase/phosphodiesterase 6
 9029
 0.22
chr16_30663214_30663498 0.20 PRR14
 proline rich 14
 845
 0.38
chr6_128116207_128116358 0.20 THEMIS
 thymocyte selection associated
 105821
 0.07
chr2_87088838_87088989 0.20 AC111200.1
110
 0.52
chr9_134158483_134158787 0.20 PPAPDC3
 phosphatidic acid phosphatase type 2 domain containing 3
 6446
 0.19
chr11_130030979_130031130 0.20 ST14
 suppression of tumorigenicity 14 (colon carcinoma)
 1597
 0.48
chr20_62327781_62327932 0.20 TNFRSF6B
 tumor necrosis factor receptor superfamily, member 6b, decoy
 165
 0.89
chr20_32063520_32063671 0.20 CBFA2T2
 core-binding factor, runt domain, alpha subunit 2; translocated to, 2
 14298
 0.16
chr20_44562270_44562484 0.20 PCIF1
 PDX1 C-terminal inhibiting factor 1
 890
 0.41
chr22_39101161_39101408 0.19 GTPBP1
 GTP binding protein 1
 444
 0.63
chr17_76894600_76894751 0.19 DDC8
 Protein DDC8 homolog
 4608
 0.16
chr15_81073049_81073200 0.19 KIAA1199
 KIAA1199
 1412
 0.48
chr17_4837349_4837633 0.19 GP1BA
 glycoprotein Ib (platelet), alpha polypeptide
 1899
 0.13
chr1_65015285_65015436 0.19 ENSG00000264470
 .
 30170
 0.22
chr10_27393964_27394336 0.19 ANKRD26
 ankyrin repeat domain 26
 4729
 0.19
chr7_43648853_43649004 0.19 STK17A
 serine/threonine kinase 17a
 26264
 0.16
chr1_1196273_1196468 0.18 UBE2J2
 ubiquitin-conjugating enzyme E2, J2
 5133
 0.08
chrX_54666603_54666913 0.18 GNL3L
 guanine nucleotide binding protein-like 3 (nucleolar)-like
 110083
 0.06
chr7_100807784_100807964 0.18 VGF
 VGF nerve growth factor inducible
 521
 0.62
chr12_113525124_113525488 0.18 DTX1
 deltex homolog 1 (Drosophila)
 29811
 0.12
chr18_13389567_13389718 0.18 LDLRAD4
 low density lipoprotein receptor class A domain containing 4
 7089
 0.16
chr11_116658070_116658327 0.18 ZNF259
 zinc finger protein 259
 497
 0.66
chr6_37492858_37493009 0.18 CCDC167
 coiled-coil domain containing 167
 25235
 0.17
chr1_19792513_19792785 0.18 CAPZB
 capping protein (actin filament) muscle Z-line, beta
 17930
 0.15
chr4_2413440_2413605 0.18 ZFYVE28
 zinc finger, FYVE domain containing 28
 5130
 0.2
chr6_11710027_11710178 0.17 ENSG00000207419
 .
 50
 0.98
chr4_114711563_114711838 0.17 CAMK2D
 calcium/calmodulin-dependent protein kinase II delta
 28617
 0.25
chr6_71403946_71404097 0.17 SMAP1
 small ArfGAP 1
 26400
 0.25
chr1_6116555_6116706 0.17 KCNAB2
 potassium voltage-gated channel, shaker-related subfamily, beta member 2
 10456
 0.17
chr20_22982685_22982836 0.17 RP4-753D10.5
28662
 0.14
chr22_48594558_48594851 0.17 ENSG00000266508
 .
 75472
 0.13
chr17_2907221_2907372 0.17 CTD-3060P21.1
38107
 0.15
chr2_71577502_71577653 0.17 ZNF638
 zinc finger protein 638
 14982
 0.21
chr19_4173171_4173322 0.16 SIRT6
 sirtuin 6
 9030
 0.11
chr17_7217900_7218108 0.16 GPS2
 G protein pathway suppressor 2
 438
 0.57
chr17_2728637_2728798 0.16 RAP1GAP2
 RAP1 GTPase activating protein 2
 28941
 0.16
chr22_20254654_20254883 0.16 RTN4R
 reticulon 4 receptor
 444
 0.76
chr2_75068651_75069070 0.16 HK2
 hexokinase 2
 6563
 0.27
chr1_160596062_160596341 0.16 SLAMF1
 signaling lymphocytic activation molecule family member 1
 20610
 0.14
chr14_105532458_105532739 0.15 GPR132
 G protein-coupled receptor 132
 816
 0.63
chr15_100880792_100881029 0.15 ADAMTS17
 ADAM metallopeptidase with thrombospondin type 1 motif, 17
 431
 0.87
chr8_1430433_1430590 0.15 DLGAP2
 discs, large (Drosophila) homolog-associated protein 2
 19021
 0.28
chr12_123463756_123463907 0.15 ARL6IP4
 ADP-ribosylation-like factor 6 interacting protein 4
 776
 0.47
chr19_1880685_1880847 0.15 ABHD17A
 abhydrolase domain containing 17A
 818
 0.41
chr16_86017398_86017670 0.15 IRF8
 interferon regulatory factor 8
 69615
 0.12
chr16_89486022_89486173 0.15 RP1-168P16.1
2537
 0.2
chr2_8630425_8630719 0.14 AC011747.7
185324
 0.03
chr2_128391549_128391703 0.14 RP11-286H15.1
7203
 0.14
chr17_71593303_71593454 0.14 RP11-277J6.2
43787
 0.15
chr11_27721228_27721573 0.14 BDNF
 brain-derived neurotrophic factor
 186
 0.96
chr6_158990244_158990658 0.14 TMEM181
 transmembrane protein 181
 32983
 0.16
chr3_52306854_52307095 0.14 ENSG00000199150
 .
 4595
 0.1
chr16_69500758_69500909 0.14 CYB5B
 cytochrome b5 type B (outer mitochondrial membrane)
 42147
 0.12
chr12_62859890_62860041 0.14 MON2
 MON2 homolog (S. cerevisiae)
 632
 0.74
chr19_34973449_34973600 0.14 WTIP
 Wilms tumor 1 interacting protein
 91
 0.96
chr17_70716063_70716406 0.14 ENSG00000222545
 .
 5624
 0.27
chr2_230579828_230580138 0.14 DNER
 delta/notch-like EGF repeat containing
 709
 0.76
chr1_6074601_6074752 0.14 KCNAB2
 potassium voltage-gated channel, shaker-related subfamily, beta member 2
 11684
 0.17
chr3_59940204_59940355 0.14 NPCDR1
 nasopharyngeal carcinoma, down-regulated 1
 17304
 0.31
chr5_131813246_131813397 0.14 AC116366.6
4586
 0.15
chr16_79446696_79446975 0.13 ENSG00000222244
 .
 148484
 0.04
chr4_8231570_8231721 0.13 SH3TC1
 SH3 domain and tetratricopeptide repeats 1
 10926
 0.22
chr2_239192445_239192596 0.13 AC012485.1
 Uncharacterized protein
 191
 0.91

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of REST

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.1 0.2 GO:0031580 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.1 0.1 GO:0019049 evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.1 0.2 GO:0045343 MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343)
0.0 0.3 GO:0006546 glycine catabolic process(GO:0006546)
0.0 0.2 GO:0031053 primary miRNA processing(GO:0031053)
0.0 0.2 GO:0046668 regulation of retinal cell programmed cell death(GO:0046668)
0.0 0.2 GO:0045956 positive regulation of calcium ion-dependent exocytosis(GO:0045956)
0.0 0.1 GO:0019987 obsolete negative regulation of anti-apoptosis(GO:0019987)
0.0 0.1 GO:2001012 mesenchymal cell differentiation involved in kidney development(GO:0072161) metanephric mesenchymal cell differentiation(GO:0072162) mesenchymal cell differentiation involved in renal system development(GO:2001012)
0.0 0.1 GO:0070670 response to interleukin-4(GO:0070670)
0.0 0.1 GO:2000696 nephron tubule epithelial cell differentiation(GO:0072160) regulation of nephron tubule epithelial cell differentiation(GO:0072182) regulation of epithelial cell differentiation involved in kidney development(GO:2000696)
0.0 0.1 GO:0001705 ectoderm formation(GO:0001705)
0.0 0.1 GO:0033152 immunoglobulin V(D)J recombination(GO:0033152)
0.0 0.2 GO:0051085 chaperone mediated protein folding requiring cofactor(GO:0051085)
0.0 0.1 GO:0030223 neutrophil differentiation(GO:0030223)
0.0 0.1 GO:0031282 regulation of guanylate cyclase activity(GO:0031282)
0.0 0.1 GO:0046877 regulation of saliva secretion(GO:0046877)
0.0 0.1 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.0 0.1 GO:0071698 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.0 0.0 GO:0010831 positive regulation of myotube differentiation(GO:0010831)
0.0 0.1 GO:0001880 Mullerian duct regression(GO:0001880)
0.0 0.1 GO:0043320 natural killer cell activation involved in immune response(GO:0002323) natural killer cell degranulation(GO:0043320)
0.0 0.1 GO:0035162 embryonic hemopoiesis(GO:0035162)
0.0 0.0 GO:0060435 bronchiole development(GO:0060435)
0.0 0.4 GO:0051865 protein autoubiquitination(GO:0051865)
0.0 0.0 GO:0072216 positive regulation of metanephros development(GO:0072216)
0.0 0.0 GO:0030952 establishment or maintenance of cytoskeleton polarity(GO:0030952)
0.0 0.1 GO:0045059 positive thymic T cell selection(GO:0045059)
0.0 0.0 GO:0000103 sulfate assimilation(GO:0000103)
0.0 0.1 GO:0033962 cytoplasmic mRNA processing body assembly(GO:0033962)
0.0 0.0 GO:0043368 positive T cell selection(GO:0043368)
0.0 0.1 GO:0051708 intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) regulation by virus of viral protein levels in host cell(GO:0046719) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708)
0.0 0.1 GO:0051570 regulation of histone H3-K9 methylation(GO:0051570)
0.0 0.0 GO:0016080 synaptic vesicle targeting(GO:0016080)
0.0 0.0 GO:0018094 protein polyglycylation(GO:0018094)
0.0 0.0 GO:0045163 clustering of voltage-gated potassium channels(GO:0045163)
0.0 0.3 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.0 0.1 GO:0035195 gene silencing by miRNA(GO:0035195)
0.0 0.0 GO:0034219 carbohydrate transmembrane transport(GO:0034219)
0.0 0.0 GO:0051176 positive regulation of sulfur metabolic process(GO:0051176)
0.0 0.1 GO:0045651 positive regulation of macrophage differentiation(GO:0045651)
0.0 0.1 GO:0051491 positive regulation of filopodium assembly(GO:0051491)
0.0 0.2 GO:0050691 regulation of defense response to virus by host(GO:0050691)
0.0 0.0 GO:0009405 pathogenesis(GO:0009405)
0.0 0.1 GO:0006896 Golgi to endosome transport(GO:0006895) Golgi to vacuole transport(GO:0006896)
0.0 0.1 GO:0014009 glial cell proliferation(GO:0014009)
0.0 0.0 GO:0045901 translational frameshifting(GO:0006452) positive regulation of translational elongation(GO:0045901) positive regulation of translational termination(GO:0045905)
0.0 0.1 GO:0032464 positive regulation of protein homooligomerization(GO:0032464)
0.0 0.1 GO:0048741 skeletal muscle fiber development(GO:0048741)
0.0 0.0 GO:0048388 endosomal lumen acidification(GO:0048388)
0.0 0.1 GO:0043084 penile erection(GO:0043084)
0.0 0.0 GO:0035405 histone-threonine phosphorylation(GO:0035405)
0.0 0.0 GO:0045006 DNA deamination(GO:0045006)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 0.1 GO:0043218 compact myelin(GO:0043218)
0.0 0.1 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.0 0.1 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 0.1 GO:0034451 centriolar satellite(GO:0034451)
0.0 0.2 GO:0042101 T cell receptor complex(GO:0042101)
0.0 0.5 GO:0005637 nuclear inner membrane(GO:0005637)
0.0 0.1 GO:0005947 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947)
0.0 0.0 GO:0070188 obsolete Stn1-Ten1 complex(GO:0070188)
0.0 0.0 GO:0042584 chromaffin granule(GO:0042583) chromaffin granule membrane(GO:0042584)
0.0 0.0 GO:0005954 calcium- and calmodulin-dependent protein kinase complex(GO:0005954)
0.0 0.0 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.0 0.1 GO:0008274 gamma-tubulin large complex(GO:0000931) gamma-tubulin ring complex(GO:0008274)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.1 0.2 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.1 0.2 GO:0042608 T cell receptor binding(GO:0042608)
0.1 0.3 GO:0004047 aminomethyltransferase activity(GO:0004047)
0.0 0.1 GO:0004340 glucokinase activity(GO:0004340)
0.0 0.2 GO:0008158 hedgehog receptor activity(GO:0008158)
0.0 0.1 GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.0 0.1 GO:0045499 chemorepellent activity(GO:0045499)
0.0 0.1 GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977) RNA polymerase II regulatory region DNA binding(GO:0001012)
0.0 0.1 GO:0004176 ATP-dependent peptidase activity(GO:0004176)
0.0 0.1 GO:0005114 type II transforming growth factor beta receptor binding(GO:0005114)
0.0 0.1 GO:0004308 exo-alpha-sialidase activity(GO:0004308) alpha-sialidase activity(GO:0016997)
0.0 0.0 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.0 0.1 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.2 GO:0017091 AU-rich element binding(GO:0017091)
0.0 0.1 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
0.0 0.0 GO:0004966 galanin receptor activity(GO:0004966)
0.0 0.1 GO:0005112 Notch binding(GO:0005112)
0.0 0.1 GO:0008967 phosphoglycolate phosphatase activity(GO:0008967)
0.0 0.2 GO:0042288 MHC class I protein binding(GO:0042288)
0.0 0.0 GO:0070735 protein-glycine ligase activity(GO:0070735)
0.0 0.1 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 0.2 GO:0004890 GABA-A receptor activity(GO:0004890)
0.0 0.0 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
0.0 0.0 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
0.0 0.1 GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor(GO:0016624)
0.0 0.1 GO:0017070 U6 snRNA binding(GO:0017070)
0.0 0.0 GO:0042285 UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285)
0.0 0.0 GO:0055077 gap junction hemi-channel activity(GO:0055077)
0.0 0.1 GO:0001727 lipid kinase activity(GO:0001727)
0.0 0.0 GO:0004396 hexokinase activity(GO:0004396)
0.0 0.4 GO:0004629 phospholipase C activity(GO:0004629)
0.0 0.0 GO:0004995 tachykinin receptor activity(GO:0004995)
0.0 0.0 GO:0005047 signal recognition particle binding(GO:0005047)
0.0 0.0 GO:0035184 histone threonine kinase activity(GO:0035184)
0.0 0.1 GO:0005095 GTPase inhibitor activity(GO:0005095)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.0 0.4 PID ARF6 PATHWAY Arf6 signaling events
0.0 0.3 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events
0.0 0.1 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.0 0.3 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 0.3 REACTOME EGFR DOWNREGULATION Genes involved in EGFR downregulation
0.0 0.0 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
0.0 0.4 REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.0 0.1 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.3 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 0.2 REACTOME MICRORNA MIRNA BIOGENESIS Genes involved in MicroRNA (miRNA) Biogenesis