CREMA results: REST

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Transcription factors associated with REST

Gene Symbol	Gene ID	Gene Info
REST Ensembl NCBI GeneCards UniProt	ENSG00000084093.11	RE1 silencing transcription factor

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

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CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
chr4_57772726_57772877	REST	1274	0.462181	0.79	1.2e-02	Click!
chr4_57777906_57778057	REST	3906	0.227338	0.85	3.9e-03	Click!
chr4_57778173_57778407	REST	4215	0.221384	0.84	4.3e-03	Click!
chr4_57779546_57779697	REST	5546	0.205075	0.84	4.8e-03	Click!
chr4_57780484_57780729	REST	6531	0.198074	0.76	1.7e-02	Click!

Showing 1 to 5 of 5 entries

Activity of the REST motif across conditions

Conditions sorted by the z-value of the REST motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

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Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr2_16105641_16106067	1.20	ENSG00000243541	.	14751	0.18
chr16_12629710_12629861	1.09	RP11-552C15.1		9554	0.21
chr4_170745007_170745217	1.07	ENSG00000264713	.	38681	0.18
chr19_41812316_41812501	1.05	CCDC97	coiled-coil domain containing 97	3686	0.14
chr1_226839240_226839391	1.04	ITPKB-IT1	ITPKB intronic transcript 1 (non-protein coding)	8056	0.22
chr17_7238988_7239233	1.03	ACAP1	ArfGAP with coiled-coil, ankyrin repeat and PH domains 1	738	0.35
chr1_167403849_167404021	1.03	RP11-104L21.2		23963	0.18
chr14_99650324_99650558	0.99	AL162151.4		25688	0.22
chr17_47872778_47872961	0.99	KAT7	K(lysine) acetyltransferase 7	5854	0.16
chrX_71998101_71998349	0.99	FAM226B	family with sequence similarity 226, member B (non-protein coding)	793	0.49

Showing 1 to 10 of 200 entries

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of REST

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0042149	cellular response to glucose starvation(GO:0042149)
0.0	0.4	GO:0051865	protein autoubiquitination(GO:0051865)
0.0	0.3	GO:0006546	glycine catabolic process(GO:0006546)
0.0	0.3	GO:0016338	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.1	0.2	GO:0031580	membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.1	0.2	GO:0045343	MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343)
0.0	0.2	GO:0031053	primary miRNA processing(GO:0031053)
0.0	0.2	GO:0046668	regulation of retinal cell programmed cell death(GO:0046668)
0.0	0.2	GO:0045956	positive regulation of calcium ion-dependent exocytosis(GO:0045956)
0.0	0.2	GO:0051085	chaperone mediated protein folding requiring cofactor(GO:0051085)

Showing 1 to 10 of 54 entries

Gene overrepresentation in cellular component category:

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Total log-likelihood	Term	Description
0.5	GO:0005637	nuclear inner membrane(GO:0005637)
0.2	GO:0032588	trans-Golgi network membrane(GO:0032588)
0.2	GO:0042101	T cell receptor complex(GO:0042101)
0.1	GO:0043218	compact myelin(GO:0043218)
0.1	GO:0042105	alpha-beta T cell receptor complex(GO:0042105)
0.1	GO:0044224	juxtaparanode region of axon(GO:0044224)
0.1	GO:0034451	centriolar satellite(GO:0034451)
0.1	GO:0005947	mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947)
0.1	GO:0008274	gamma-tubulin large complex(GO:0000931) gamma-tubulin ring complex(GO:0008274)
0.0	GO:0070188	obsolete Stn1-Ten1 complex(GO:0070188)

Showing 1 to 10 of 13 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0017112	Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0	0.4	GO:0004629	phospholipase C activity(GO:0004629)
0.1	0.3	GO:0004047	aminomethyltransferase activity(GO:0004047)
0.1	0.2	GO:0004591	oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.1	0.2	GO:0042608	T cell receptor binding(GO:0042608)
0.0	0.2	GO:0008158	hedgehog receptor activity(GO:0008158)
0.0	0.2	GO:0017091	AU-rich element binding(GO:0017091)
0.0	0.2	GO:0042288	MHC class I protein binding(GO:0042288)
0.0	0.2	GO:0004890	GABA-A receptor activity(GO:0004890)
0.0	0.1	GO:0004340	glucokinase activity(GO:0004340)

Showing 1 to 10 of 36 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Total log-likelihood	Term	Description
0.4	PID ARF6 PATHWAY	Arf6 signaling events
0.3	PID IL8 CXCR2 PATHWAY	IL8- and CXCR2-mediated signaling events
0.2	PID AR TF PATHWAY	Regulation of Androgen receptor activity
0.1	ST PAC1 RECEPTOR PATHWAY	PAC1 Receptor Pathway

Showing 1 to 4 of 4 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Total log-likelihood	Term	Description
0.4	REACTOME ACTIVATION OF BH3 ONLY PROTEINS	Genes involved in Activation of BH3-only proteins
0.4	REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS	Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.3	REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.3	REACTOME EGFR DOWNREGULATION	Genes involved in EGFR downregulation
0.3	REACTOME TIGHT JUNCTION INTERACTIONS	Genes involved in Tight junction interactions
0.2	REACTOME MICRORNA MIRNA BIOGENESIS	Genes involved in MicroRNA (miRNA) Biogenesis
0.1	REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion

Showing 1 to 8 of 8 entries

Results for REST

Z-value: 1.41

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Transcription factors associated with REST

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Activity of the REST motif across conditions

Conditions sorted by the z-value of the REST motif activity

Top target CREs of the motif:

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of REST

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: