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ENCODE: H3K4me1 ChIP-Seq of primary human cells
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Results for RFX3_RFX2

Z-value: 1.26

Motif logo

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Transcription factors associated with RFX3_RFX2

Gene Symbol Gene ID Gene Info
RFX3
ENSG00000080298.11 regulatory factor X3
RFX2
ENSG00000087903.8 regulatory factor X2

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr19_6218924_6219075RFX2194590.142616-0.781.3e-02Click!
chr19_6198434_6198600RFX210230.508666-0.771.6e-02Click!
chr19_6058304_6058655RFX211850.405586-0.599.6e-02Click!
chr19_6048454_6048605RFX27140.610772-0.581.0e-01Click!
chr19_6116813_6116964RFX231160.190831-0.581.0e-01Click!
chr9_3585317_3585468RFX3593880.154767-0.817.7e-03Click!
chr9_3241340_3241491RFX3157840.2971690.713.2e-02Click!
chr9_3385948_3386099RFX395650.3006630.713.4e-02Click!
chr9_3371502_3371653RFX3240110.2629440.703.7e-02Click!
chr9_3513364_3513515RFX3125440.2670210.694.2e-02Click!

Activity of the RFX3_RFX2 motif across conditions

Conditions sorted by the z-value of the RFX3_RFX2 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr17_75880240_75880391 0.83 FLJ45079
1656
 0.44
chr17_70927455_70927642 0.71 SLC39A11
 solute carrier family 39, member 11
 61524
 0.13
chr16_29675395_29675762 0.66 QPRT
 quinolinate phosphoribosyltransferase
 978
 0.33
chr11_6426621_6426772 0.64 APBB1
 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
 25
 0.97
chr9_95710407_95710684 0.60 FGD3
 FYVE, RhoGEF and PH domain containing 3
 812
 0.67
chr20_57697083_57697234 0.58 ZNF831
 zinc finger protein 831
 68917
 0.09
chr2_74225778_74225929 0.55 TET3
 tet methylcytosine dioxygenase 3
 3987
 0.19
chr2_69001325_69001580 0.53 ARHGAP25
 Rho GTPase activating protein 25
 481
 0.85
chr7_100797498_100797649 0.52 AP1S1
 adaptor-related protein complex 1, sigma 1 subunit
 105
 0.93
chr16_58529133_58529329 0.52 ENSG00000200556
 .
 1581
 0.29
chr17_2719169_2719653 0.50 RAP1GAP2
 RAP1 GTPase activating protein 2
 19635
 0.17
chr11_66046306_66046457 0.49 CNIH2
 cornichon family AMPA receptor auxiliary protein 2
 711
 0.33
chr1_54821646_54821879 0.49 SSBP3
 single stranded DNA binding protein 3
 49415
 0.13
chr22_51015749_51015963 0.46 CPT1B
 carnitine palmitoyltransferase 1B (muscle)
 593
 0.5
chr3_190335086_190335237 0.46 IL1RAP
 interleukin 1 receptor accessory protein
 2064
 0.4
chr1_155937640_155937991 0.46 ARHGEF2
 Rho/Rac guanine nucleotide exchange factor (GEF) 2
 1705
 0.2
chr2_162852228_162852540 0.45 ENSG00000253046
 .
 77092
 0.09
chr7_99699541_99699692 0.45 MCM7
 minichromosome maintenance complex component 7
 53
 0.49
chr9_129486180_129486331 0.45 ENSG00000266403
 .
 5643
 0.25
chr16_14290018_14290169 0.43 CTA-276F8.2
4041
 0.23
chr14_62378459_62378610 0.43 SYT16
 synaptotagmin XVI
 75269
 0.12
chr2_235392806_235393340 0.43 ARL4C
 ADP-ribosylation factor-like 4C
 12171
 0.32
chr19_1450029_1450180 0.43 APC2
 adenomatosis polyposis coli 2
 44
 0.93
chrX_71343660_71344077 0.42 RGAG4
 retrotransposon gag domain containing 4
 7810
 0.16
chr14_89657538_89657839 0.42 FOXN3
 forkhead box N3
 10600
 0.29
chr7_44665547_44665813 0.41 OGDH
 oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
 1619
 0.38
chr9_90896091_90896335 0.41 ENSG00000252299
 .
 92971
 0.09
chr2_74682400_74682551 0.40 INO80B
 INO80 complex subunit B
 232
 0.8
chr19_47250973_47251124 0.40 FKRP
 fukutin related protein
 132
 0.87
chr19_46981657_46981850 0.40 PNMAL1
 paraneoplastic Ma antigen family-like 1
 6933
 0.14
chr1_154913860_154914149 0.40 PMVK
 phosphomevalonate kinase
 4537
 0.1
chr18_13374841_13375108 0.40 LDLRAD4
 low density lipoprotein receptor class A domain containing 4
 7579
 0.17
chr11_47554537_47554716 0.40 CELF1
 CUGBP, Elav-like family member 1
 8293
 0.09
chr1_109133745_109133896 0.40 FAM102B
 family with sequence similarity 102, member B
 31109
 0.18
chr2_204738870_204739080 0.40 CTLA4
 cytotoxic T-lymphocyte-associated protein 4
 4020
 0.3
chr17_33600795_33600946 0.39 SLFN5
 schlafen family member 5
 30762
 0.13
chr2_99271555_99271876 0.39 MGAT4A
 mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
 8221
 0.22
chr1_153916783_153917044 0.39 DENND4B
 DENN/MADD domain containing 4B
 347
 0.75
chr2_8615480_8615853 0.39 AC011747.7
200230
 0.03
chr9_92148429_92148580 0.38 SEMA4D
 sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
 35459
 0.17
chr3_32501721_32501872 0.38 CMTM6
 CKLF-like MARVEL transmembrane domain containing 6
 43104
 0.15
chr19_36360210_36360411 0.37 APLP1
 amyloid beta (A4) precursor-like protein 1
 65
 0.94
chr9_117322529_117322680 0.37 ENSG00000238530
 .
 5028
 0.19
chrX_70382960_70383111 0.37 NLGN3
 neuroligin 3
 18323
 0.11
chr4_36270764_36270915 0.37 DTHD1
 death domain containing 1
 12405
 0.2
chr11_46136037_46136224 0.37 ENSG00000263539
 .
 1361
 0.46
chr9_20990073_20990336 0.37 PTPLAD2
 protein tyrosine phosphatase-like A domain containing 2
 41404
 0.14
chr15_60987699_60987850 0.37 RP11-219B17.2
13948
 0.21
chr11_73676931_73677082 0.36 DNAJB13
 DnaJ (Hsp40) homolog, subfamily B, member 13
 725
 0.45
chr19_4535388_4535581 0.36 PLIN5
 perilipin 5
 248
 0.84
chr5_147162353_147162504 0.36 JAKMIP2
 janus kinase and microtubule interacting protein 2
 90
 0.98
chr16_2891959_2892474 0.36 ZG16B
 zymogen granule protein 16B
 11847
 0.08
chr12_109016386_109016729 0.35 RP11-689B22.2
5906
 0.14
chr5_156722366_156722517 0.35 CYFIP2
 cytoplasmic FMR1 interacting protein 2
 10069
 0.15
chr12_58132887_58133904 0.35 AGAP2
 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
 1366
 0.18
chr12_7342719_7343041 0.34 PEX5
 peroxisomal biogenesis factor 5
 77
 0.94
chr20_3869217_3869437 0.34 PANK2
 pantothenate kinase 2
 159
 0.53
chr12_51818434_51818585 0.34 SLC4A8
 solute carrier family 4, sodium bicarbonate cotransporter, member 8
 46
 0.58
chr12_56132220_56132570 0.34 GDF11
 growth differentiation factor 11
 4669
 0.09
chr1_110798062_110798354 0.34 ENSG00000200536
 .
 16898
 0.14
chr15_71185021_71185318 0.34 LRRC49
 leucine rich repeat containing 49
 2
 0.52
chr3_46742373_46742524 0.34 TMIE
 transmembrane inner ear
 375
 0.8
chr17_26900998_26901149 0.33 RP11-192H23.5
938
 0.26
chr7_66041728_66041879 0.33 KCTD7
 potassium channel tetramerization domain containing 7
 52065
 0.13
chr20_55035634_55035893 0.33 ENSG00000212084
 .
 350
 0.82
chrX_150562148_150562449 0.33 VMA21
 VMA21 vacuolar H+-ATPase homolog (S. cerevisiae)
 2740
 0.39
chr3_39168975_39169272 0.33 GORASP1
 golgi reassembly stacking protein 1, 65kDa
 19269
 0.15
chr21_43846575_43846827 0.32 ENSG00000252619
 .
 8999
 0.14
chr8_81953365_81953516 0.32 PAG1
 phosphoprotein associated with glycosphingolipid microdomains 1
 70863
 0.12
chr1_26864411_26864784 0.32 RPS6KA1
 ribosomal protein S6 kinase, 90kDa, polypeptide 1
 5006
 0.16
chr5_55884723_55884991 0.32 AC022431.2
 Homo sapiens uncharacterized LOC101928448 (LOC101928448), mRNA.
 17202
 0.22
chr5_61874409_61874560 0.31 LRRC70
 leucine rich repeat containing 70
 78
 0.63
chrX_42598475_42598797 0.31 ENSG00000206896
 .
 564998
 0.0
chr16_31356467_31356644 0.31 ITGAX
 integrin, alpha X (complement component 3 receptor 4 subunit)
 9900
 0.12
chr5_156586468_156586619 0.31 MED7
 mediator complex subunit 7
 513
 0.7
chr22_23487549_23487700 0.31 RAB36
 RAB36, member RAS oncogene family
 71
 0.84
chr14_65162974_65163364 0.31 PLEKHG3
 pleckstrin homology domain containing, family G (with RhoGef domain) member 3
 7651
 0.23
chr17_6734889_6735110 0.31 TEKT1
 tektin 1
 26
 0.97
chr7_142045451_142045602 0.30 PRSS3P3
 protease, serine, 3 pseudogene 3
 55917
 0.14
chr10_121258804_121258955 0.30 RGS10
 regulator of G-protein signaling 10
 28110
 0.2
chr20_57234965_57235234 0.30 STX16
 syntaxin 16
 7477
 0.17
chr14_20937424_20937613 0.30 PNP
 purine nucleoside phosphorylase
 20
 0.94
chr7_95138669_95138820 0.30 ASB4
 ankyrin repeat and SOCS box containing 4
 23531
 0.16
chr17_74978029_74978225 0.30 ENSG00000267568
 .
 12889
 0.22
chr2_198713693_198713844 0.29 PLCL1
 phospholipase C-like 1
 38786
 0.18
chr14_89866106_89866257 0.29 RP11-33N16.2
158
 0.93
chr3_71778250_71778401 0.29 EIF4E3
 eukaryotic translation initiation factor 4E family member 3
 23
 0.98
chr8_129402575_129402726 0.29 ENSG00000201782
 .
 169900
 0.04
chr11_65320301_65320458 0.29 LTBP3
 latent transforming growth factor beta binding protein 3
 819
 0.39
chr6_25056414_25056861 0.29 FAM65B
 family with sequence similarity 65, member B
 14399
 0.17
chr4_103256948_103257099 0.29 SLC39A8
 solute carrier family 39 (zinc transporter), member 8
 9273
 0.24
chr2_3199960_3200169 0.28 TSSC1-IT1
 TSSC1 intronic transcript 1 (non-protein coding)
 105172
 0.07
chr19_54386580_54386731 0.28 PRKCG
 protein kinase C, gamma
 258
 0.79
chr7_63360674_63360857 0.28 ENSG00000263891
 .
 681
 0.75
chr15_31597386_31597537 0.28 KLF13
 Kruppel-like factor 13
 21597
 0.26
chr5_171568580_171569009 0.28 STK10
 serine/threonine kinase 10
 46596
 0.13
chr11_67164503_67164739 0.28 ENSG00000253024
 .
 1839
 0.14
chr1_15573599_15573750 0.28 FHAD1
 forkhead-associated (FHA) phosphopeptide binding domain 1
 94
 0.98
chr1_204676341_204676492 0.28 ENSG00000252650
 .
 142
 0.95
chr5_141443572_141443736 0.27 NDFIP1
 Nedd4 family interacting protein 1
 44416
 0.13
chr7_150445905_150446107 0.27 GIMAP5
 GTPase, IMAP family member 5
 11570
 0.15
chr8_116506284_116506435 0.27 TRPS1
 trichorhinophalangeal syndrome I
 1911
 0.43
chr9_95786581_95786807 0.27 FGD3
 FYVE, RhoGEF and PH domain containing 3
 9352
 0.19
chr13_22681448_22681599 0.27 ENSG00000244197
 .
 316847
 0.01
chr14_91716372_91716859 0.27 GPR68
 G protein-coupled receptor 68
 3609
 0.21
chr22_20232840_20233022 0.27 RTN4R
 reticulon 4 receptor
 1724
 0.26
chr10_103156966_103157117 0.27 ENSG00000239091
 .
 25332
 0.15
chr9_112143935_112144086 0.27 PTPN3
 protein tyrosine phosphatase, non-receptor type 3
 36053
 0.16
chr7_100147991_100148484 0.27 AGFG2
 ArfGAP with FG repeats 2
 5053
 0.1
chr1_11415693_11415844 0.27 UBIAD1
 UbiA prenyltransferase domain containing 1
 81777
 0.08
chr1_37979556_37979715 0.27 MEAF6
 MYST/Esa1-associated factor 6
 235
 0.9
chr11_94667622_94667942 0.26 RP11-856F16.2
9096
 0.21
chr3_71516692_71516843 0.26 ENSG00000221264
 .
 74473
 0.1
chr7_142509095_142509291 0.26 PRSS3P2
 protease, serine, 3 pseudogene 2
 28062
 0.14
chr10_73527049_73527307 0.26 C10orf54
 chromosome 10 open reading frame 54
 6077
 0.2
chr3_156874680_156874970 0.26 CCNL1
 cyclin L1
 3177
 0.18
chr19_38701329_38701480 0.26 ENSG00000266428
 .
 10530
 0.1
chr15_63566686_63566895 0.26 APH1B
 APH1B gamma secretase subunit
 1427
 0.51
chr17_37042407_37042584 0.26 LASP1
 LIM and SH3 protein 1
 12352
 0.09
chr14_69821644_69821841 0.25 ERH
 enhancer of rudimentary homolog (Drosophila)
 43274
 0.15
chr1_40852173_40852453 0.25 SMAP2
 small ArfGAP2
 10194
 0.17
chr4_25953528_25953679 0.25 SMIM20
 small integral membrane protein 20
 37672
 0.21
chr6_112173949_112174100 0.25 FYN
 FYN oncogene related to SRC, FGR, YES
 5562
 0.31
chr12_7285279_7285430 0.25 CLSTN3
 calsyntenin 3
 372
 0.71
chr2_136806710_136807017 0.25 AC093391.2
36828
 0.17
chr19_887253_887404 0.25 MED16
 mediator complex subunit 16
 1419
 0.21
chr13_52702919_52703070 0.24 NEK5
 NIMA-related kinase 5
 220
 0.94
chr20_57692521_57692800 0.24 ZNF831
 zinc finger protein 831
 73415
 0.08
chr8_125700066_125700362 0.24 MTSS1
 metastasis suppressor 1
 39643
 0.18
chr3_60090466_60090753 0.24 NPCDR1
 nasopharyngeal carcinoma, down-regulated 1
 133026
 0.06
chr13_100312339_100312490 0.23 ENSG00000263615
 .
 17101
 0.17
chr20_47411084_47411357 0.23 PREX1
 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
 33200
 0.2
chr6_3371209_3371360 0.23 RP11-506K6.4
59388
 0.12
chr15_31633972_31634233 0.23 KLF13
 Kruppel-like factor 13
 1966
 0.48
chr10_98776932_98777125 0.23 RP11-175O19.4
24821
 0.17
chr21_36258797_36258993 0.23 RUNX1
 runt-related transcription factor 1
 585
 0.85
chr20_43160480_43160631 0.23 PKIG
 protein kinase (cAMP-dependent, catalytic) inhibitor gamma
 2
 0.97
chr1_26254194_26254345 0.23 ENSG00000266763
 .
 16029
 0.09
chr14_74181133_74181284 0.23 PNMA1
 paraneoplastic Ma antigen 1
 80
 0.95
chr20_56014752_56014903 0.23 RP4-800J21.3
46709
 0.11
chr1_90004720_90004909 0.23 LRRC8B
 leucine rich repeat containing 8 family, member B
 14352
 0.23
chr22_25506759_25506910 0.22 CTA-221G9.11
1825
 0.4
chr8_38215820_38215998 0.22 RP11-513D5.2
22410
 0.11
chr11_44633175_44633394 0.22 RP11-58K22.4
3633
 0.23
chr4_101028462_101028642 0.22 ENSG00000222196
 .
 22640
 0.21
chr17_78676894_78677122 0.22 RP11-28G8.1
102424
 0.06
chr8_121753435_121753586 0.22 RP11-713M15.1
19983
 0.24
chr7_5421938_5422198 0.22 TNRC18
 trinucleotide repeat containing 18
 5592
 0.18
chr8_144252428_144252579 0.22 LY6H
 lymphocyte antigen 6 complex, locus H
 10375
 0.16
chr21_18885134_18885388 0.22 CXADR
 coxsackie virus and adenovirus receptor
 103
 0.96
chr12_52399828_52400077 0.21 GRASP
 GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein
 772
 0.54
chr8_126964557_126964708 0.21 ENSG00000206695
 .
 51437
 0.18
chr8_21916516_21916667 0.21 DMTN
 dematin actin binding protein
 95
 0.95
chr1_6240317_6240494 0.21 CHD5
 chromodomain helicase DNA binding protein 5
 222
 0.9
chr2_66805662_66805813 0.21 MEIS1
 Meis homeobox 1
 69678
 0.12
chr19_42681420_42681571 0.21 ENSG00000265122
 .
 15735
 0.09
chr4_153567518_153567669 0.21 RP11-768B22.2
19927
 0.2
chr16_16108547_16108698 0.21 ABCC1
 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
 4909
 0.28
chr8_9938825_9938976 0.21 ENSG00000221320
 .
 6531
 0.21
chr2_242811687_242811838 0.21 CXXC11
 CXXC finger protein 11
 119
 0.94
chr17_72743837_72744129 0.21 ENSG00000264624
 .
 769
 0.29
chr3_10264247_10264398 0.21 ENSG00000222348
 .
 5426
 0.14
chr12_53469532_53469768 0.21 SPRYD3
 SPRY domain containing 3
 3511
 0.14
chr6_4022482_4022687 0.20 PRPF4B
 pre-mRNA processing factor 4B
 657
 0.55
chr15_75085688_75085876 0.20 CSK
 c-src tyrosine kinase
 397
 0.76
chr11_130015072_130015223 0.20 ST14
 suppression of tumorigenicity 14 (colon carcinoma)
 14310
 0.23
chr22_36655380_36655684 0.20 APOL1
 apolipoprotein L, 1
 6325
 0.19
chr11_3972295_3973084 0.20 STIM1
 stromal interaction molecule 1
 4116
 0.21
chr2_62534017_62534171 0.20 ENSG00000238809
 .
 41964
 0.15
chr10_103600006_103600198 0.20 KCNIP2
 Kv channel interacting protein 2
 473
 0.78
chr2_228342039_228342286 0.20 AGFG1
 ArfGAP with FG repeats 1
 5074
 0.22
chr15_42067029_42067517 0.20 MAPKBP1
 mitogen-activated protein kinase binding protein 1
 373
 0.79
chr21_32531106_32531735 0.20 TIAM1
 T-cell lymphoma invasion and metastasis 1
 28881
 0.23
chr7_143893706_143894410 0.20 RP4-545C24.1
1077
 0.31
chr22_51111995_51112214 0.20 SHANK3
 SH3 and multiple ankyrin repeat domains 3
 739
 0.5
chr16_57167003_57167154 0.20 CPNE2
 copine II
 13967
 0.14
chr13_95160544_95160695 0.20 DCT
 dopachrome tautomerase
 28683
 0.18
chr17_9963172_9963323 0.20 GAS7
 growth arrest-specific 7
 115
 0.97
chr6_167553041_167553192 0.20 TCP10L2
 t-complex 10-like 2
 9852
 0.18
chr17_57643431_57643582 0.19 DHX40
 DEAH (Asp-Glu-Ala-His) box polypeptide 40
 522
 0.79
chr19_39685929_39686134 0.19 NCCRP1
 non-specific cytotoxic cell receptor protein 1 homolog (zebrafish)
 1570
 0.27
chr2_198164541_198165310 0.19 ANKRD44-IT1
 ANKRD44 intronic transcript 1 (non-protein coding)
 2318
 0.26
chr22_23864162_23864510 0.19 AP000345.2
44915
 0.12
chr7_143992274_143992984 0.19 ARHGEF35
 Rho guanine nucleotide exchange factor (GEF) 35
 1399
 0.27
chr19_47791608_47791812 0.19 C5AR1
 complement component 5a receptor 1
 8622
 0.13
chr1_234899784_234900028 0.19 ENSG00000201638
 .
 73814
 0.11
chr18_3059365_3059574 0.19 ENSG00000252258
 .
 33905
 0.13
chr18_44252416_44252567 0.19 LOXHD1
 lipoxygenase homology domains 1
 15495
 0.24
chr2_169821016_169821290 0.19 SPC25
 SPC25, NDC80 kinetochore complex component
 51366
 0.13
chr17_1198651_1199134 0.19 TUSC5
 tumor suppressor candidate 5
 15935
 0.17
chr5_1111654_1111805 0.19 SLC12A7
 solute carrier family 12 (potassium/chloride transporter), member 7
 421
 0.84
chr6_109694572_109695063 0.19 CD164
 CD164 molecule, sialomucin
 8086
 0.15
chr6_161664290_161664508 0.19 AGPAT4
 1-acylglycerol-3-phosphate O-acyltransferase 4
 30652
 0.25
chr1_226188532_226188755 0.19 SDE2
 SDE2 telomere maintenance homolog (S. pombe)
 1611
 0.34
chrX_110284379_110284718 0.19 PAK3
 p21 protein (Cdc42/Rac)-activated kinase 3
 55040
 0.17
chr6_41168159_41168310 0.18 TREML2
 triggering receptor expressed on myeloid cells-like 2
 698
 0.58
chr9_82302025_82302205 0.18 TLE4
 transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
 17583
 0.31
chr16_84633341_84633527 0.18 RP11-61F12.1
5435
 0.19
chr19_57352226_57352377 0.18 ZIM2
 zinc finger, imprinted 2
 204
 0.49
chr12_69555824_69555975 0.18 ENSG00000252547
 .
 44467
 0.16

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of RFX3_RFX2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0072526 pyridine-containing compound catabolic process(GO:0072526)
0.1 0.2 GO:0043983 histone H4-K12 acetylation(GO:0043983)
0.1 0.3 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.1 0.6 GO:0045749 obsolete negative regulation of S phase of mitotic cell cycle(GO:0045749)
0.1 0.4 GO:0035414 negative regulation of catenin import into nucleus(GO:0035414)
0.1 0.2 GO:0002524 hypersensitivity(GO:0002524) regulation of hypersensitivity(GO:0002883)
0.1 0.2 GO:0045163 clustering of voltage-gated potassium channels(GO:0045163)
0.1 0.2 GO:0061117 negative regulation of cardiac muscle tissue growth(GO:0055022) negative regulation of cardiac muscle tissue development(GO:0055026) negative regulation of cardiac muscle cell proliferation(GO:0060044) negative regulation of heart growth(GO:0061117)
0.1 0.2 GO:0060839 endothelial cell fate commitment(GO:0060839)
0.0 0.2 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.0 0.2 GO:0045589 regulation of regulatory T cell differentiation(GO:0045589)
0.0 0.1 GO:0061154 endothelial tube morphogenesis(GO:0061154)
0.0 0.2 GO:0007256 activation of JNKK activity(GO:0007256)
0.0 0.0 GO:0031558 obsolete induction of apoptosis in response to chemical stimulus(GO:0031558)
0.0 0.1 GO:0015820 branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820)
0.0 0.1 GO:0007258 JUN phosphorylation(GO:0007258)
0.0 0.3 GO:0016558 protein import into peroxisome matrix(GO:0016558)
0.0 0.2 GO:1902603 carnitine shuttle(GO:0006853) carnitine transmembrane transport(GO:1902603)
0.0 0.2 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.0 0.1 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0 0.1 GO:0010459 negative regulation of heart rate(GO:0010459)
0.0 0.1 GO:0070071 proton-transporting two-sector ATPase complex assembly(GO:0070071)
0.0 0.1 GO:0042511 positive regulation of tyrosine phosphorylation of Stat1 protein(GO:0042511)
0.0 0.6 GO:0050690 regulation of defense response to virus by virus(GO:0050690)
0.0 0.2 GO:0035082 axoneme assembly(GO:0035082)
0.0 0.0 GO:0002890 negative regulation of B cell mediated immunity(GO:0002713) negative regulation of immunoglobulin mediated immune response(GO:0002890)
0.0 0.2 GO:0006491 N-glycan processing(GO:0006491)
0.0 0.0 GO:0045990 carbon catabolite regulation of transcription(GO:0045990) regulation of transcription by glucose(GO:0046015)
0.0 0.1 GO:0051299 centrosome separation(GO:0051299)
0.0 0.4 GO:0006298 mismatch repair(GO:0006298)
0.0 0.1 GO:0033152 immunoglobulin V(D)J recombination(GO:0033152)
0.0 0.1 GO:0006435 threonyl-tRNA aminoacylation(GO:0006435)
0.0 0.0 GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling(GO:0014067)
0.0 0.0 GO:0090232 positive regulation of spindle checkpoint(GO:0090232) regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267) positive regulation of cell cycle checkpoint(GO:1901978) regulation of mitotic spindle checkpoint(GO:1903504)
0.0 0.0 GO:0030210 heparin biosynthetic process(GO:0030210)
0.0 0.1 GO:0032456 endocytic recycling(GO:0032456)
0.0 0.2 GO:0002437 inflammatory response to antigenic stimulus(GO:0002437)
0.0 0.0 GO:1903053 regulation of extracellular matrix disassembly(GO:0010715) negative regulation of extracellular matrix disassembly(GO:0010716) regulation of extracellular matrix organization(GO:1903053) negative regulation of extracellular matrix organization(GO:1903054)
0.0 0.1 GO:0010759 positive regulation of macrophage chemotaxis(GO:0010759)
0.0 0.0 GO:0007195 adenylate cyclase-inhibiting dopamine receptor signaling pathway(GO:0007195)
0.0 0.3 GO:0030818 negative regulation of cAMP metabolic process(GO:0030815) negative regulation of cAMP biosynthetic process(GO:0030818)
0.0 0.1 GO:1901341 activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0 0.4 GO:0046847 filopodium assembly(GO:0046847)
0.0 0.0 GO:0060287 epithelial cilium movement(GO:0003351) epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
0.0 0.1 GO:0031293 membrane protein intracellular domain proteolysis(GO:0031293)
0.0 0.1 GO:0006198 cAMP catabolic process(GO:0006198)
0.0 0.1 GO:0010614 negative regulation of cardiac muscle hypertrophy(GO:0010614)
0.0 0.1 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.0 0.1 GO:0006554 lysine metabolic process(GO:0006553) lysine catabolic process(GO:0006554)
0.0 0.1 GO:0051319 mitotic G2 phase(GO:0000085) G2 phase(GO:0051319)
0.0 0.0 GO:0001911 negative regulation of leukocyte mediated cytotoxicity(GO:0001911)
0.0 0.2 GO:0015701 bicarbonate transport(GO:0015701)
0.0 0.0 GO:0010867 positive regulation of triglyceride biosynthetic process(GO:0010867)
0.0 0.0 GO:0042362 fat-soluble vitamin biosynthetic process(GO:0042362)
0.0 0.0 GO:0098868 endochondral bone growth(GO:0003416) growth plate cartilage development(GO:0003417) bone growth(GO:0098868)
0.0 0.0 GO:0071354 cellular response to interleukin-6(GO:0071354)
0.0 0.1 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 0.0 GO:1902745 positive regulation of lamellipodium assembly(GO:0010592) positive regulation of lamellipodium organization(GO:1902745)
0.0 0.0 GO:0032898 neurotrophin production(GO:0032898)
0.0 0.0 GO:0032713 negative regulation of interleukin-4 production(GO:0032713)
0.0 0.2 GO:0042094 interleukin-2 biosynthetic process(GO:0042094)
0.0 0.1 GO:0042976 activation of Janus kinase activity(GO:0042976)
0.0 0.1 GO:0006884 cell volume homeostasis(GO:0006884)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.1 0.2 GO:0000138 Golgi trans cisterna(GO:0000138)
0.0 0.4 GO:0016342 catenin complex(GO:0016342)
0.0 0.2 GO:0070776 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0 0.3 GO:0005845 mRNA cap binding complex(GO:0005845) RNA cap binding complex(GO:0034518)
0.0 0.2 GO:0001931 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0 0.1 GO:0070062 extracellular exosome(GO:0070062) extracellular vesicle(GO:1903561)
0.0 0.2 GO:0042555 MCM complex(GO:0042555)
0.0 0.4 GO:0090665 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.1 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.0 0.1 GO:0005594 collagen type IX trimer(GO:0005594)
0.0 0.1 GO:0042382 paraspeckles(GO:0042382)
0.0 0.1 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.0 GO:0071438 invadopodium membrane(GO:0071438)
0.0 0.3 GO:0005811 lipid particle(GO:0005811)
0.0 0.1 GO:0005655 nucleolar ribonuclease P complex(GO:0005655) ribonuclease P complex(GO:0030677) multimeric ribonuclease P complex(GO:0030681)
0.0 0.1 GO:0030126 COPI vesicle coat(GO:0030126)
0.0 0.1 GO:0031264 death-inducing signaling complex(GO:0031264)
0.0 0.7 GO:0030426 growth cone(GO:0030426)
0.0 0.3 GO:0016592 mediator complex(GO:0016592)
0.0 0.1 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.0 0.0 GO:0031931 TORC1 complex(GO:0031931)
0.0 0.0 GO:0005686 U2 snRNP(GO:0005686)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0002060 purine nucleobase binding(GO:0002060)
0.1 0.3 GO:0000268 peroxisome targeting sequence binding(GO:0000268)
0.1 0.2 GO:0004514 nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514)
0.1 0.3 GO:0031694 alpha-2A adrenergic receptor binding(GO:0031694)
0.1 0.2 GO:0016416 carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.1 0.2 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.1 0.6 GO:0070064 proline-rich region binding(GO:0070064)
0.1 0.2 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.1 0.2 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0 0.2 GO:0004594 pantothenate kinase activity(GO:0004594)
0.0 0.2 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0 0.1 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.0 0.1 GO:0032554 purine deoxyribonucleotide binding(GO:0032554) adenyl deoxyribonucleotide binding(GO:0032558)
0.0 0.1 GO:0004705 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0 0.1 GO:0015379 potassium:chloride symporter activity(GO:0015379)
0.0 0.1 GO:0003917 DNA topoisomerase type I activity(GO:0003917)
0.0 0.1 GO:0003701 obsolete RNA polymerase I transcription factor activity(GO:0003701)
0.0 0.1 GO:0070579 methylcytosine dioxygenase activity(GO:0070579)
0.0 0.3 GO:0051635 obsolete bacterial cell surface binding(GO:0051635)
0.0 0.1 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 0.1 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.0 0.1 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.0 0.2 GO:0004908 interleukin-1 receptor activity(GO:0004908)
0.0 0.1 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.0 0.2 GO:0071617 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) lysophosphatidic acid acyltransferase activity(GO:0042171) lysophospholipid acyltransferase activity(GO:0071617)
0.0 0.3 GO:0004697 protein kinase C activity(GO:0004697)
0.0 0.2 GO:0003706 obsolete ligand-regulated transcription factor activity(GO:0003706)
0.0 0.1 GO:0030375 thyroid hormone receptor coactivator activity(GO:0030375)
0.0 0.1 GO:0004829 threonine-tRNA ligase activity(GO:0004829)
0.0 0.0 GO:0031690 adrenergic receptor binding(GO:0031690)
0.0 0.1 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 0.0 GO:0002054 nucleobase binding(GO:0002054)
0.0 0.0 GO:0004167 dopachrome isomerase activity(GO:0004167)
0.0 0.0 GO:0047238 glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.0 0.1 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.1 GO:0035255 ionotropic glutamate receptor binding(GO:0035255)
0.0 0.1 GO:0030020 extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.0 0.7 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 0.0 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.0 0.2 GO:0005452 inorganic anion exchanger activity(GO:0005452)
0.0 0.4 GO:0008013 beta-catenin binding(GO:0008013)
0.0 0.1 GO:0090079 translation regulator activity, nucleic acid binding(GO:0090079)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.2 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.0 0.7 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 0.4 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events
0.0 0.1 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 0.0 SA TRKA RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.3 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.0 0.3 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0 0.2 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.0 0.2 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 0.2 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0 0.1 REACTOME REGULATED PROTEOLYSIS OF P75NTR Genes involved in Regulated proteolysis of p75NTR
0.0 0.1 REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.0 0.6 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 0.2 REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0 0.3 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.0 0.0 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
0.0 0.0 REACTOME CDT1 ASSOCIATION WITH THE CDC6 ORC ORIGIN COMPLEX Genes involved in CDT1 association with the CDC6:ORC:origin complex
0.0 0.1 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 0.2 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 0.1 REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1