Project

ENCODE: H3K4me1 ChIP-Seq of primary human cells

Navigation

Downloads

CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for RFX3_RFX2

Z-value: 1.26

Motif logo

Transcription factors associated with RFX3_RFX2

Gene Symbol	Gene ID	Gene Info
RFX3 Ensembl NCBI GeneCards UniProt	ENSG00000080298.11	RFX3
RFX2 Ensembl NCBI GeneCards UniProt	ENSG00000087903.8	RFX2

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
RFX2	chr19_6218924_6219075	19459	0.142616	-0.78	1.3e-02	Click!
RFX2	chr19_6198434_6198600	1023	0.508666	-0.77	1.6e-02	Click!
RFX2	chr19_6058304_6058655	1185	0.405586	-0.59	9.6e-02	Click!
RFX2	chr19_6048454_6048605	714	0.610772	-0.58	1.0e-01	Click!
RFX2	chr19_6116813_6116964	3116	0.190831	-0.58	1.0e-01	Click!
RFX3	chr9_3585317_3585468	59388	0.154767	-0.81	7.7e-03	Click!
RFX3	chr9_3241340_3241491	15784	0.297169	0.71	3.2e-02	Click!
RFX3	chr9_3385948_3386099	9565	0.300663	0.71	3.4e-02	Click!
RFX3	chr9_3371502_3371653	24011	0.262944	0.70	3.7e-02	Click!
RFX3	chr9_3513364_3513515	12544	0.267021	0.69	4.2e-02	Click!

Activity of the RFX3_RFX2 motif across conditions

Conditions sorted by the z-value of the RFX3_RFX2 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr17_75880240_75880391	0.83	FLJ45079		1656	0.44
chr17_70927455_70927642	0.71	SLC39A11	solute carrier family 39, member 11	61524	0.13
chr16_29675395_29675762	0.66	QPRT	quinolinate phosphoribosyltransferase	978	0.33
chr11_6426621_6426772	0.64	APBB1	amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)	25	0.97
chr9_95710407_95710684	0.60	FGD3	FYVE, RhoGEF and PH domain containing 3	812	0.67
chr20_57697083_57697234	0.58	ZNF831	zinc finger protein 831	68917	0.09
chr2_74225778_74225929	0.55	TET3	tet methylcytosine dioxygenase 3	3987	0.19
chr2_69001325_69001580	0.53	ARHGAP25	Rho GTPase activating protein 25	481	0.85
chr7_100797498_100797649	0.52	AP1S1	adaptor-related protein complex 1, sigma 1 subunit	105	0.93
chr16_58529133_58529329	0.52	ENSG00000200556	.	1581	0.29
chr17_2719169_2719653	0.50	RAP1GAP2	RAP1 GTPase activating protein 2	19635	0.17
chr11_66046306_66046457	0.49	CNIH2	cornichon family AMPA receptor auxiliary protein 2	711	0.33
chr1_54821646_54821879	0.49	SSBP3	single stranded DNA binding protein 3	49415	0.13
chr22_51015749_51015963	0.46	CPT1B	carnitine palmitoyltransferase 1B (muscle)	593	0.5
chr3_190335086_190335237	0.46	IL1RAP	interleukin 1 receptor accessory protein	2064	0.4
chr1_155937640_155937991	0.46	ARHGEF2	Rho/Rac guanine nucleotide exchange factor (GEF) 2	1705	0.2
chr2_162852228_162852540	0.45	ENSG00000253046	.	77092	0.09
chr7_99699541_99699692	0.45	MCM7	minichromosome maintenance complex component 7	53	0.49
chr9_129486180_129486331	0.45	ENSG00000266403	.	5643	0.25
chr16_14290018_14290169	0.43	CTA-276F8.2		4041	0.23
chr14_62378459_62378610	0.43	SYT16	synaptotagmin XVI	75269	0.12
chr2_235392806_235393340	0.43	ARL4C	ADP-ribosylation factor-like 4C	12171	0.32
chr19_1450029_1450180	0.43	APC2	adenomatosis polyposis coli 2	44	0.93
chrX_71343660_71344077	0.42	RGAG4	retrotransposon gag domain containing 4	7810	0.16
chr14_89657538_89657839	0.42	FOXN3	forkhead box N3	10600	0.29
chr7_44665547_44665813	0.41	OGDH	oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)	1619	0.38
chr9_90896091_90896335	0.41	ENSG00000252299	.	92971	0.09
chr2_74682400_74682551	0.40	INO80B	INO80 complex subunit B	232	0.8
chr19_47250973_47251124	0.40	FKRP	fukutin related protein	132	0.87
chr19_46981657_46981850	0.40	PNMAL1	paraneoplastic Ma antigen family-like 1	6933	0.14
chr1_154913860_154914149	0.40	PMVK	phosphomevalonate kinase	4537	0.1
chr18_13374841_13375108	0.40	LDLRAD4	low density lipoprotein receptor class A domain containing 4	7579	0.17
chr11_47554537_47554716	0.40	CELF1	CUGBP, Elav-like family member 1	8293	0.09
chr1_109133745_109133896	0.40	FAM102B	family with sequence similarity 102, member B	31109	0.18
chr2_204738870_204739080	0.40	CTLA4	cytotoxic T-lymphocyte-associated protein 4	4020	0.3
chr17_33600795_33600946	0.39	SLFN5	schlafen family member 5	30762	0.13
chr2_99271555_99271876	0.39	MGAT4A	mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A	8221	0.22
chr1_153916783_153917044	0.39	DENND4B	DENN/MADD domain containing 4B	347	0.75
chr2_8615480_8615853	0.39	AC011747.7		200230	0.03
chr9_92148429_92148580	0.38	SEMA4D	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D	35459	0.17
chr3_32501721_32501872	0.38	CMTM6	CKLF-like MARVEL transmembrane domain containing 6	43104	0.15
chr19_36360210_36360411	0.37	APLP1	amyloid beta (A4) precursor-like protein 1	65	0.94
chr9_117322529_117322680	0.37	ENSG00000238530	.	5028	0.19
chrX_70382960_70383111	0.37	NLGN3	neuroligin 3	18323	0.11
chr4_36270764_36270915	0.37	DTHD1	death domain containing 1	12405	0.2
chr11_46136037_46136224	0.37	ENSG00000263539	.	1361	0.46
chr9_20990073_20990336	0.37	PTPLAD2	protein tyrosine phosphatase-like A domain containing 2	41404	0.14
chr15_60987699_60987850	0.37	RP11-219B17.2		13948	0.21
chr11_73676931_73677082	0.36	DNAJB13	DnaJ (Hsp40) homolog, subfamily B, member 13	725	0.45
chr19_4535388_4535581	0.36	PLIN5	perilipin 5	248	0.84
chr5_147162353_147162504	0.36	JAKMIP2	janus kinase and microtubule interacting protein 2	90	0.98
chr16_2891959_2892474	0.36	ZG16B	zymogen granule protein 16B	11847	0.08
chr12_109016386_109016729	0.35	RP11-689B22.2		5906	0.14
chr5_156722366_156722517	0.35	CYFIP2	cytoplasmic FMR1 interacting protein 2	10069	0.15
chr12_58132887_58133904	0.35	AGAP2	ArfGAP with GTPase domain, ankyrin repeat and PH domain 2	1366	0.18
chr12_7342719_7343041	0.34	PEX5	peroxisomal biogenesis factor 5	77	0.94
chr20_3869217_3869437	0.34	PANK2	pantothenate kinase 2	159	0.53
chr12_51818434_51818585	0.34	SLC4A8	solute carrier family 4, sodium bicarbonate cotransporter, member 8	46	0.58
chr12_56132220_56132570	0.34	GDF11	growth differentiation factor 11	4669	0.09
chr1_110798062_110798354	0.34	ENSG00000200536	.	16898	0.14
chr15_71185021_71185318	0.34	LRRC49	leucine rich repeat containing 49	2	0.52
chr3_46742373_46742524	0.34	TMIE	transmembrane inner ear	375	0.8
chr17_26900998_26901149	0.33	RP11-192H23.5		938	0.26
chr7_66041728_66041879	0.33	KCTD7	potassium channel tetramerization domain containing 7	52065	0.13
chr20_55035634_55035893	0.33	ENSG00000212084	.	350	0.82
chrX_150562148_150562449	0.33	VMA21	VMA21 vacuolar H+-ATPase homolog (S. cerevisiae)	2740	0.39
chr3_39168975_39169272	0.33	GORASP1	golgi reassembly stacking protein 1, 65kDa	19269	0.15
chr21_43846575_43846827	0.32	ENSG00000252619	.	8999	0.14
chr8_81953365_81953516	0.32	PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	70863	0.12
chr1_26864411_26864784	0.32	RPS6KA1	ribosomal protein S6 kinase, 90kDa, polypeptide 1	5006	0.16
chr5_55884723_55884991	0.32	AC022431.2	Homo sapiens uncharacterized LOC101928448 (LOC101928448), mRNA.	17202	0.22
chr5_61874409_61874560	0.31	LRRC70	leucine rich repeat containing 70	78	0.63
chrX_42598475_42598797	0.31	ENSG00000206896	.	564998	0.0
chr16_31356467_31356644	0.31	ITGAX	integrin, alpha X (complement component 3 receptor 4 subunit)	9900	0.12
chr5_156586468_156586619	0.31	MED7	mediator complex subunit 7	513	0.7
chr22_23487549_23487700	0.31	RAB36	RAB36, member RAS oncogene family	71	0.84
chr14_65162974_65163364	0.31	PLEKHG3	pleckstrin homology domain containing, family G (with RhoGef domain) member 3	7651	0.23
chr17_6734889_6735110	0.31	TEKT1	tektin 1	26	0.97
chr7_142045451_142045602	0.30	PRSS3P3	protease, serine, 3 pseudogene 3	55917	0.14
chr10_121258804_121258955	0.30	RGS10	regulator of G-protein signaling 10	28110	0.2
chr20_57234965_57235234	0.30	STX16	syntaxin 16	7477	0.17
chr14_20937424_20937613	0.30	PNP	purine nucleoside phosphorylase	20	0.94
chr7_95138669_95138820	0.30	ASB4	ankyrin repeat and SOCS box containing 4	23531	0.16
chr17_74978029_74978225	0.30	ENSG00000267568	.	12889	0.22
chr2_198713693_198713844	0.29	PLCL1	phospholipase C-like 1	38786	0.18
chr14_89866106_89866257	0.29	RP11-33N16.2		158	0.93
chr3_71778250_71778401	0.29	EIF4E3	eukaryotic translation initiation factor 4E family member 3	23	0.98
chr8_129402575_129402726	0.29	ENSG00000201782	.	169900	0.04
chr11_65320301_65320458	0.29	LTBP3	latent transforming growth factor beta binding protein 3	819	0.39
chr6_25056414_25056861	0.29	FAM65B	family with sequence similarity 65, member B	14399	0.17
chr4_103256948_103257099	0.29	SLC39A8	solute carrier family 39 (zinc transporter), member 8	9273	0.24
chr2_3199960_3200169	0.28	TSSC1-IT1	TSSC1 intronic transcript 1 (non-protein coding)	105172	0.07
chr19_54386580_54386731	0.28	PRKCG	protein kinase C, gamma	258	0.79
chr7_63360674_63360857	0.28	ENSG00000263891	.	681	0.75
chr15_31597386_31597537	0.28	KLF13	Kruppel-like factor 13	21597	0.26
chr5_171568580_171569009	0.28	STK10	serine/threonine kinase 10	46596	0.13
chr11_67164503_67164739	0.28	ENSG00000253024	.	1839	0.14
chr1_15573599_15573750	0.28	FHAD1	forkhead-associated (FHA) phosphopeptide binding domain 1	94	0.98
chr1_204676341_204676492	0.28	ENSG00000252650	.	142	0.95
chr5_141443572_141443736	0.27	NDFIP1	Nedd4 family interacting protein 1	44416	0.13
chr7_150445905_150446107	0.27	GIMAP5	GTPase, IMAP family member 5	11570	0.15
chr8_116506284_116506435	0.27	TRPS1	trichorhinophalangeal syndrome I	1911	0.43
chr9_95786581_95786807	0.27	FGD3	FYVE, RhoGEF and PH domain containing 3	9352	0.19
chr13_22681448_22681599	0.27	ENSG00000244197	.	316847	0.01
chr14_91716372_91716859	0.27	GPR68	G protein-coupled receptor 68	3609	0.21
chr22_20232840_20233022	0.27	RTN4R	reticulon 4 receptor	1724	0.26
chr10_103156966_103157117	0.27	ENSG00000239091	.	25332	0.15
chr9_112143935_112144086	0.27	PTPN3	protein tyrosine phosphatase, non-receptor type 3	36053	0.16
chr7_100147991_100148484	0.27	AGFG2	ArfGAP with FG repeats 2	5053	0.1
chr1_11415693_11415844	0.27	UBIAD1	UbiA prenyltransferase domain containing 1	81777	0.08
chr1_37979556_37979715	0.27	MEAF6	MYST/Esa1-associated factor 6	235	0.9
chr11_94667622_94667942	0.26	RP11-856F16.2		9096	0.21
chr3_71516692_71516843	0.26	ENSG00000221264	.	74473	0.1
chr7_142509095_142509291	0.26	PRSS3P2	protease, serine, 3 pseudogene 2	28062	0.14
chr10_73527049_73527307	0.26	C10orf54	chromosome 10 open reading frame 54	6077	0.2
chr3_156874680_156874970	0.26	CCNL1	cyclin L1	3177	0.18
chr19_38701329_38701480	0.26	ENSG00000266428	.	10530	0.1
chr15_63566686_63566895	0.26	APH1B	APH1B gamma secretase subunit	1427	0.51
chr17_37042407_37042584	0.26	LASP1	LIM and SH3 protein 1	12352	0.09
chr14_69821644_69821841	0.25	ERH	enhancer of rudimentary homolog (Drosophila)	43274	0.15
chr1_40852173_40852453	0.25	SMAP2	small ArfGAP2	10194	0.17
chr4_25953528_25953679	0.25	SMIM20	small integral membrane protein 20	37672	0.21
chr6_112173949_112174100	0.25	FYN	FYN oncogene related to SRC, FGR, YES	5562	0.31
chr12_7285279_7285430	0.25	CLSTN3	calsyntenin 3	372	0.71
chr2_136806710_136807017	0.25	AC093391.2		36828	0.17
chr19_887253_887404	0.25	MED16	mediator complex subunit 16	1419	0.21
chr13_52702919_52703070	0.24	NEK5	NIMA-related kinase 5	220	0.94
chr20_57692521_57692800	0.24	ZNF831	zinc finger protein 831	73415	0.08
chr8_125700066_125700362	0.24	MTSS1	metastasis suppressor 1	39643	0.18
chr3_60090466_60090753	0.24	NPCDR1	nasopharyngeal carcinoma, down-regulated 1	133026	0.06
chr13_100312339_100312490	0.23	ENSG00000263615	.	17101	0.17
chr20_47411084_47411357	0.23	PREX1	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1	33200	0.2
chr6_3371209_3371360	0.23	RP11-506K6.4		59388	0.12
chr15_31633972_31634233	0.23	KLF13	Kruppel-like factor 13	1966	0.48
chr10_98776932_98777125	0.23	RP11-175O19.4		24821	0.17
chr21_36258797_36258993	0.23	RUNX1	runt-related transcription factor 1	585	0.85
chr20_43160480_43160631	0.23	PKIG	protein kinase (cAMP-dependent, catalytic) inhibitor gamma	2	0.97
chr1_26254194_26254345	0.23	ENSG00000266763	.	16029	0.09
chr14_74181133_74181284	0.23	PNMA1	paraneoplastic Ma antigen 1	80	0.95
chr20_56014752_56014903	0.23	RP4-800J21.3		46709	0.11
chr1_90004720_90004909	0.23	LRRC8B	leucine rich repeat containing 8 family, member B	14352	0.23
chr22_25506759_25506910	0.22	CTA-221G9.11		1825	0.4
chr8_38215820_38215998	0.22	RP11-513D5.2		22410	0.11
chr11_44633175_44633394	0.22	RP11-58K22.4		3633	0.23
chr4_101028462_101028642	0.22	ENSG00000222196	.	22640	0.21
chr17_78676894_78677122	0.22	RP11-28G8.1		102424	0.06
chr8_121753435_121753586	0.22	RP11-713M15.1		19983	0.24
chr7_5421938_5422198	0.22	TNRC18	trinucleotide repeat containing 18	5592	0.18
chr8_144252428_144252579	0.22	LY6H	lymphocyte antigen 6 complex, locus H	10375	0.16
chr21_18885134_18885388	0.22	CXADR	coxsackie virus and adenovirus receptor	103	0.96
chr12_52399828_52400077	0.21	GRASP	GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein	772	0.54
chr8_126964557_126964708	0.21	ENSG00000206695	.	51437	0.18
chr8_21916516_21916667	0.21	DMTN	dematin actin binding protein	95	0.95
chr1_6240317_6240494	0.21	CHD5	chromodomain helicase DNA binding protein 5	222	0.9
chr2_66805662_66805813	0.21	MEIS1	Meis homeobox 1	69678	0.12
chr19_42681420_42681571	0.21	ENSG00000265122	.	15735	0.09
chr4_153567518_153567669	0.21	RP11-768B22.2		19927	0.2
chr16_16108547_16108698	0.21	ABCC1	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	4909	0.28
chr8_9938825_9938976	0.21	ENSG00000221320	.	6531	0.21
chr2_242811687_242811838	0.21	CXXC11	CXXC finger protein 11	119	0.94
chr17_72743837_72744129	0.21	ENSG00000264624	.	769	0.29
chr3_10264247_10264398	0.21	ENSG00000222348	.	5426	0.14
chr12_53469532_53469768	0.21	SPRYD3	SPRY domain containing 3	3511	0.14
chr6_4022482_4022687	0.20	PRPF4B	pre-mRNA processing factor 4B	657	0.55
chr15_75085688_75085876	0.20	CSK	c-src tyrosine kinase	397	0.76
chr11_130015072_130015223	0.20	ST14	suppression of tumorigenicity 14 (colon carcinoma)	14310	0.23
chr22_36655380_36655684	0.20	APOL1	apolipoprotein L, 1	6325	0.19
chr11_3972295_3973084	0.20	STIM1	stromal interaction molecule 1	4116	0.21
chr2_62534017_62534171	0.20	ENSG00000238809	.	41964	0.15
chr10_103600006_103600198	0.20	KCNIP2	Kv channel interacting protein 2	473	0.78
chr2_228342039_228342286	0.20	AGFG1	ArfGAP with FG repeats 1	5074	0.22
chr15_42067029_42067517	0.20	MAPKBP1	mitogen-activated protein kinase binding protein 1	373	0.79
chr21_32531106_32531735	0.20	TIAM1	T-cell lymphoma invasion and metastasis 1	28881	0.23
chr7_143893706_143894410	0.20	RP4-545C24.1		1077	0.31
chr22_51111995_51112214	0.20	SHANK3	SH3 and multiple ankyrin repeat domains 3	739	0.5
chr16_57167003_57167154	0.20	CPNE2	copine II	13967	0.14
chr13_95160544_95160695	0.20	DCT	dopachrome tautomerase	28683	0.18
chr17_9963172_9963323	0.20	GAS7	growth arrest-specific 7	115	0.97
chr6_167553041_167553192	0.20	TCP10L2	t-complex 10-like 2	9852	0.18
chr17_57643431_57643582	0.19	DHX40	DEAH (Asp-Glu-Ala-His) box polypeptide 40	522	0.79
chr19_39685929_39686134	0.19	NCCRP1	non-specific cytotoxic cell receptor protein 1 homolog (zebrafish)	1570	0.27
chr2_198164541_198165310	0.19	ANKRD44-IT1	ANKRD44 intronic transcript 1 (non-protein coding)	2318	0.26
chr22_23864162_23864510	0.19	AP000345.2		44915	0.12
chr7_143992274_143992984	0.19	ARHGEF35	Rho guanine nucleotide exchange factor (GEF) 35	1399	0.27
chr19_47791608_47791812	0.19	C5AR1	complement component 5a receptor 1	8622	0.13
chr1_234899784_234900028	0.19	ENSG00000201638	.	73814	0.11
chr18_3059365_3059574	0.19	ENSG00000252258	.	33905	0.13
chr18_44252416_44252567	0.19	LOXHD1	lipoxygenase homology domains 1	15495	0.24
chr2_169821016_169821290	0.19	SPC25	SPC25, NDC80 kinetochore complex component	51366	0.13
chr17_1198651_1199134	0.19	TUSC5	tumor suppressor candidate 5	15935	0.17
chr5_1111654_1111805	0.19	SLC12A7	solute carrier family 12 (potassium/chloride transporter), member 7	421	0.84
chr6_109694572_109695063	0.19	CD164	CD164 molecule, sialomucin	8086	0.15
chr6_161664290_161664508	0.19	AGPAT4	1-acylglycerol-3-phosphate O-acyltransferase 4	30652	0.25
chr1_226188532_226188755	0.19	SDE2	SDE2 telomere maintenance homolog (S. pombe)	1611	0.34
chrX_110284379_110284718	0.19	PAK3	p21 protein (Cdc42/Rac)-activated kinase 3	55040	0.17
chr6_41168159_41168310	0.18	TREML2	triggering receptor expressed on myeloid cells-like 2	698	0.58
chr9_82302025_82302205	0.18	TLE4	transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)	17583	0.31
chr16_84633341_84633527	0.18	RP11-61F12.1		5435	0.19
chr19_57352226_57352377	0.18	ZIM2	zinc finger, imprinted 2	204	0.49
chr12_69555824_69555975	0.18	ENSG00000252547	.	44467	0.16

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of RFX3_RFX2

View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.5	GO:0072526	pyridine-containing compound catabolic process(GO:0072526)
0.1	0.2	GO:0043983	histone H4-K12 acetylation(GO:0043983)
0.1	0.3	GO:0006610	ribosomal protein import into nucleus(GO:0006610)
0.1	0.6	GO:0045749	obsolete negative regulation of S phase of mitotic cell cycle(GO:0045749)
0.1	0.4	GO:0035414	negative regulation of catenin import into nucleus(GO:0035414)
0.1	0.2	GO:0002524	hypersensitivity(GO:0002524) regulation of hypersensitivity(GO:0002883)
0.1	0.2	GO:0045163	clustering of voltage-gated potassium channels(GO:0045163)
0.1	0.2	GO:0061117	negative regulation of cardiac muscle tissue growth(GO:0055022) negative regulation of cardiac muscle tissue development(GO:0055026) negative regulation of cardiac muscle cell proliferation(GO:0060044) negative regulation of heart growth(GO:0061117)
0.1	0.2	GO:0060839	endothelial cell fate commitment(GO:0060839)
0.0	0.2	GO:0030854	positive regulation of granulocyte differentiation(GO:0030854)
0.0	0.2	GO:0045589	regulation of regulatory T cell differentiation(GO:0045589)
0.0	0.1	GO:0061154	endothelial tube morphogenesis(GO:0061154)
0.0	0.2	GO:0007256	activation of JNKK activity(GO:0007256)
0.0	0.0	GO:0031558	obsolete induction of apoptosis in response to chemical stimulus(GO:0031558)
0.0	0.1	GO:0015820	branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820)
0.0	0.1	GO:0007258	JUN phosphorylation(GO:0007258)
0.0	0.3	GO:0016558	protein import into peroxisome matrix(GO:0016558)
0.0	0.2	GO:1902603	carnitine shuttle(GO:0006853) carnitine transmembrane transport(GO:1902603)
0.0	0.2	GO:0015937	coenzyme A biosynthetic process(GO:0015937)
0.0	0.1	GO:0030388	fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0	0.1	GO:0010459	negative regulation of heart rate(GO:0010459)
0.0	0.1	GO:0070071	proton-transporting two-sector ATPase complex assembly(GO:0070071)
0.0	0.1	GO:0042511	positive regulation of tyrosine phosphorylation of Stat1 protein(GO:0042511)
0.0	0.6	GO:0050690	regulation of defense response to virus by virus(GO:0050690)
0.0	0.2	GO:0035082	axoneme assembly(GO:0035082)
0.0	0.0	GO:0002890	negative regulation of B cell mediated immunity(GO:0002713) negative regulation of immunoglobulin mediated immune response(GO:0002890)
0.0	0.2	GO:0006491	N-glycan processing(GO:0006491)
0.0	0.0	GO:0045990	carbon catabolite regulation of transcription(GO:0045990) regulation of transcription by glucose(GO:0046015)
0.0	0.1	GO:0051299	centrosome separation(GO:0051299)
0.0	0.4	GO:0006298	mismatch repair(GO:0006298)
0.0	0.1	GO:0033152	immunoglobulin V(D)J recombination(GO:0033152)
0.0	0.1	GO:0006435	threonyl-tRNA aminoacylation(GO:0006435)
0.0	0.0	GO:0014067	negative regulation of phosphatidylinositol 3-kinase signaling(GO:0014067)
0.0	0.0	GO:0090232	positive regulation of spindle checkpoint(GO:0090232) regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267) positive regulation of cell cycle checkpoint(GO:1901978) regulation of mitotic spindle checkpoint(GO:1903504)
0.0	0.0	GO:0030210	heparin biosynthetic process(GO:0030210)
0.0	0.1	GO:0032456	endocytic recycling(GO:0032456)
0.0	0.2	GO:0002437	inflammatory response to antigenic stimulus(GO:0002437)
0.0	0.0	GO:1903053	regulation of extracellular matrix disassembly(GO:0010715) negative regulation of extracellular matrix disassembly(GO:0010716) regulation of extracellular matrix organization(GO:1903053) negative regulation of extracellular matrix organization(GO:1903054)
0.0	0.1	GO:0010759	positive regulation of macrophage chemotaxis(GO:0010759)
0.0	0.0	GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway(GO:0007195)
0.0	0.3	GO:0030818	negative regulation of cAMP metabolic process(GO:0030815) negative regulation of cAMP biosynthetic process(GO:0030818)
0.0	0.1	GO:1901341	activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0	0.4	GO:0046847	filopodium assembly(GO:0046847)
0.0	0.0	GO:0060287	epithelial cilium movement(GO:0003351) epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
0.0	0.1	GO:0031293	membrane protein intracellular domain proteolysis(GO:0031293)
0.0	0.1	GO:0006198	cAMP catabolic process(GO:0006198)
0.0	0.1	GO:0010614	negative regulation of cardiac muscle hypertrophy(GO:0010614)
0.0	0.1	GO:0006268	DNA unwinding involved in DNA replication(GO:0006268)
0.0	0.1	GO:0006554	lysine metabolic process(GO:0006553) lysine catabolic process(GO:0006554)
0.0	0.1	GO:0051319	mitotic G2 phase(GO:0000085) G2 phase(GO:0051319)
0.0	0.0	GO:0001911	negative regulation of leukocyte mediated cytotoxicity(GO:0001911)
0.0	0.2	GO:0015701	bicarbonate transport(GO:0015701)
0.0	0.0	GO:0010867	positive regulation of triglyceride biosynthetic process(GO:0010867)
0.0	0.0	GO:0042362	fat-soluble vitamin biosynthetic process(GO:0042362)
0.0	0.0	GO:0098868	endochondral bone growth(GO:0003416) growth plate cartilage development(GO:0003417) bone growth(GO:0098868)
0.0	0.0	GO:0071354	cellular response to interleukin-6(GO:0071354)
0.0	0.1	GO:0006607	NLS-bearing protein import into nucleus(GO:0006607)
0.0	0.0	GO:1902745	positive regulation of lamellipodium assembly(GO:0010592) positive regulation of lamellipodium organization(GO:1902745)
0.0	0.0	GO:0032898	neurotrophin production(GO:0032898)
0.0	0.0	GO:0032713	negative regulation of interleukin-4 production(GO:0032713)
0.0	0.2	GO:0042094	interleukin-2 biosynthetic process(GO:0042094)
0.0	0.1	GO:0042976	activation of Janus kinase activity(GO:0042976)
0.0	0.1	GO:0006884	cell volume homeostasis(GO:0006884)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.5	GO:0030121	AP-1 adaptor complex(GO:0030121)
0.1	0.2	GO:0000138	Golgi trans cisterna(GO:0000138)
0.0	0.4	GO:0016342	catenin complex(GO:0016342)
0.0	0.2	GO:0070776	H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0	0.3	GO:0005845	mRNA cap binding complex(GO:0005845) RNA cap binding complex(GO:0034518)
0.0	0.2	GO:0001931	uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0	0.1	GO:0070062	extracellular exosome(GO:0070062) extracellular vesicle(GO:1903561)
0.0	0.2	GO:0042555	MCM complex(GO:0042555)
0.0	0.4	GO:0090665	dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0	0.1	GO:0005896	interleukin-6 receptor complex(GO:0005896)
0.0	0.1	GO:0005594	collagen type IX trimer(GO:0005594)
0.0	0.1	GO:0042382	paraspeckles(GO:0042382)
0.0	0.1	GO:0030127	COPII vesicle coat(GO:0030127)
0.0	0.0	GO:0071438	invadopodium membrane(GO:0071438)
0.0	0.3	GO:0005811	lipid particle(GO:0005811)
0.0	0.1	GO:0005655	nucleolar ribonuclease P complex(GO:0005655) ribonuclease P complex(GO:0030677) multimeric ribonuclease P complex(GO:0030681)
0.0	0.1	GO:0030126	COPI vesicle coat(GO:0030126)
0.0	0.1	GO:0031264	death-inducing signaling complex(GO:0031264)
0.0	0.7	GO:0030426	growth cone(GO:0030426)
0.0	0.3	GO:0016592	mediator complex(GO:0016592)
0.0	0.1	GO:0045334	clathrin-coated endocytic vesicle(GO:0045334)
0.0	0.0	GO:0031931	TORC1 complex(GO:0031931)
0.0	0.0	GO:0005686	U2 snRNP(GO:0005686)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0002060	purine nucleobase binding(GO:0002060)
0.1	0.3	GO:0000268	peroxisome targeting sequence binding(GO:0000268)
0.1	0.2	GO:0004514	nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514)
0.1	0.3	GO:0031694	alpha-2A adrenergic receptor binding(GO:0031694)
0.1	0.2	GO:0016416	carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.1	0.2	GO:0004591	oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.1	0.6	GO:0070064	proline-rich region binding(GO:0070064)
0.1	0.2	GO:0005250	A-type (transient outward) potassium channel activity(GO:0005250)
0.1	0.2	GO:0008454	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0	0.2	GO:0004594	pantothenate kinase activity(GO:0004594)
0.0	0.2	GO:0004862	cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0	0.1	GO:0004332	fructose-bisphosphate aldolase activity(GO:0004332)
0.0	0.1	GO:0032554	purine deoxyribonucleotide binding(GO:0032554) adenyl deoxyribonucleotide binding(GO:0032558)
0.0	0.1	GO:0004705	JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0	0.1	GO:0015379	potassium:chloride symporter activity(GO:0015379)
0.0	0.1	GO:0003917	DNA topoisomerase type I activity(GO:0003917)
0.0	0.1	GO:0003701	obsolete RNA polymerase I transcription factor activity(GO:0003701)
0.0	0.1	GO:0070579	methylcytosine dioxygenase activity(GO:0070579)
0.0	0.3	GO:0051635	obsolete bacterial cell surface binding(GO:0051635)
0.0	0.1	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0	0.1	GO:0030306	ADP-ribosylation factor binding(GO:0030306)
0.0	0.1	GO:0005432	calcium:sodium antiporter activity(GO:0005432)
0.0	0.2	GO:0004908	interleukin-1 receptor activity(GO:0004908)
0.0	0.1	GO:0005127	ciliary neurotrophic factor receptor binding(GO:0005127)
0.0	0.2	GO:0071617	1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) lysophosphatidic acid acyltransferase activity(GO:0042171) lysophospholipid acyltransferase activity(GO:0071617)
0.0	0.3	GO:0004697	protein kinase C activity(GO:0004697)
0.0	0.2	GO:0003706	obsolete ligand-regulated transcription factor activity(GO:0003706)
0.0	0.1	GO:0030375	thyroid hormone receptor coactivator activity(GO:0030375)
0.0	0.1	GO:0004829	threonine-tRNA ligase activity(GO:0004829)
0.0	0.0	GO:0031690	adrenergic receptor binding(GO:0031690)
0.0	0.1	GO:0070016	armadillo repeat domain binding(GO:0070016)
0.0	0.0	GO:0002054	nucleobase binding(GO:0002054)
0.0	0.0	GO:0004167	dopachrome isomerase activity(GO:0004167)
0.0	0.0	GO:0047238	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.0	0.1	GO:0030676	Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0	0.1	GO:0035255	ionotropic glutamate receptor binding(GO:0035255)
0.0	0.1	GO:0030020	extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.0	0.7	GO:0005089	Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0	0.0	GO:0000900	translation repressor activity, nucleic acid binding(GO:0000900)
0.0	0.2	GO:0005452	inorganic anion exchanger activity(GO:0005452)
0.0	0.4	GO:0008013	beta-catenin binding(GO:0008013)
0.0	0.1	GO:0090079	translation regulator activity, nucleic acid binding(GO:0090079)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.2	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.2	PID SYNDECAN 3 PATHWAY	Syndecan-3-mediated signaling events
0.7	PID ERA GENOMIC PATHWAY	Validated nuclear estrogen receptor alpha network
0.4	PID IL8 CXCR2 PATHWAY	IL8- and CXCR2-mediated signaling events
0.1	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0	SA TRKA RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.5	REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION	Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0	0.3	REACTOME PURINE SALVAGE	Genes involved in Purine salvage
0.0	0.3	REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS	Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0	0.2	REACTOME UNWINDING OF DNA	Genes involved in Unwinding of DNA
0.0	0.2	REACTOME VITAMIN B5 PANTOTHENATE METABOLISM	Genes involved in Vitamin B5 (pantothenate) metabolism
0.0	0.2	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0	0.1	REACTOME REGULATED PROTEOLYSIS OF P75NTR	Genes involved in Regulated proteolysis of p75NTR
0.0	0.1	REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS	Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.0	0.6	REACTOME NRAGE SIGNALS DEATH THROUGH JNK	Genes involved in NRAGE signals death through JNK
0.0	0.2	REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE	Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0	0.3	REACTOME BASIGIN INTERACTIONS	Genes involved in Basigin interactions
0.0	0.0	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.0	0.0	REACTOME CDT1 ASSOCIATION WITH THE CDC6 ORC ORIGIN COMPLEX	Genes involved in CDT1 association with the CDC6:ORC:origin complex
0.0	0.1	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.0	0.2	REACTOME MITOCHONDRIAL TRNA AMINOACYLATION	Genes involved in Mitochondrial tRNA aminoacylation
0.0	0.1	REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1	Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1