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ENCODE: H3K4me1 ChIP-Seq of primary human cells

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Results for RFX7_RFX4_RFX1

Z-value: 1.80

Motif logo

Transcription factors associated with RFX7_RFX4_RFX1

Gene Symbol	Gene ID	Gene Info
RFX7 Ensembl NCBI GeneCards UniProt	ENSG00000181827.10	regulatory factor X7
RFX4 Ensembl NCBI GeneCards UniProt	ENSG00000111783.8	regulatory factor X4
RFX1 Ensembl NCBI GeneCards UniProt	ENSG00000132005.4	regulatory factor X1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
chr19_14093693_14093923	RFX1	23266	0.084855	0.83	6.2e-03	Click!
chr19_14094328_14094893	RFX1	22464	0.085862	0.80	9.8e-03	Click!
chr19_14118040_14118216	RFX1	1031	0.352231	0.80	1.0e-02	Click!
chr19_14097817_14098045	RFX1	19143	0.089847	0.77	1.5e-02	Click!
chr19_14093983_14094134	RFX1	23016	0.085171	0.71	3.2e-02	Click!
chr12_106977935_106978190	RFX4	639	0.807963	0.82	6.7e-03	Click!
chr12_106977690_106977849	RFX4	346	0.923091	0.64	6.2e-02	Click!
chr12_106975162_106975313	RFX4	1448	0.535902	0.62	7.6e-02	Click!
chr12_106977124_106977281	RFX4	221	0.959320	0.61	7.8e-02	Click!
chr12_106976420_106976571	RFX4	190	0.966288	0.59	9.5e-02	Click!
chr15_56458703_56458872	RFX7	23297	0.225268	0.86	2.6e-03	Click!
chr15_56534948_56535214	RFX7	383	0.786610	0.86	3.0e-03	Click!
chr15_56478492_56478696	RFX7	3490	0.311584	0.74	2.1e-02	Click!
chr15_56437688_56437839	RFX7	44321	0.167653	-0.72	2.8e-02	Click!
chr15_56453365_56453516	RFX7	28644	0.211378	-0.72	3.0e-02	Click!

Activity of the RFX7_RFX4_RFX1 motif across conditions

Conditions sorted by the z-value of the RFX7_RFX4_RFX1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr1_32254259_32254518	1.00	RP11-84A19.3		343	0.84
chr3_71778250_71778401	0.80	EIF4E3	eukaryotic translation initiation factor 4E family member 3	23	0.98
chr1_26864411_26864784	0.79	RPS6KA1	ribosomal protein S6 kinase, 90kDa, polypeptide 1	5006	0.16
chr9_136017630_136017895	0.72	RALGDS	ral guanine nucleotide dissociation stimulator	6959	0.15
chr22_39147429_39147714	0.69	SUN2	Sad1 and UNC84 domain containing 2	1252	0.24
chr16_24550337_24550570	0.55	RBBP6	retinoblastoma binding protein 6	424	0.9
chr19_10907600_10907797	0.54	DNM2	dynamin 2	14006	0.11
chr7_2994065_2994394	0.54	AC004906.3		10560	0.21
chr11_11265492_11265720	0.54	RP11-567I13.1		108367	0.07
chr10_82116344_82116598	0.53	DYDC1	DPY30 domain containing 1	1	0.53
chr19_55791290_55791441	0.50	HSPBP1	HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1	80	0.92
chr14_72944519_72944815	0.49	RGS6	regulator of G-protein signaling 6	18290	0.3
chr5_32276641_32276844	0.49	ENSG00000207052	.	33026	0.14
chr17_71586433_71586688	0.48	RP11-277J6.2		50605	0.13
chr3_32501721_32501872	0.48	CMTM6	CKLF-like MARVEL transmembrane domain containing 6	43104	0.15
chr2_172967658_172967809	0.47	DLX2	distal-less homeobox 2	105	0.97
chr5_131336901_131337354	0.46	ACSL6	acyl-CoA synthetase long-chain family member 6	447	0.74
chr19_49376384_49376535	0.45	PPP1R15A	protein phosphatase 1, regulatory subunit 15A	810	0.4
chr10_135148910_135149072	0.45	CALY	calcyon neuron-specific vesicular protein	1385	0.21
chr15_31633972_31634233	0.45	KLF13	Kruppel-like factor 13	1966	0.48
chr17_72270377_72270944	0.44	DNAI2	dynein, axonemal, intermediate chain 2	231	0.89
chr8_119121245_119121467	0.44	EXT1	exostosin glycosyltransferase 1	1297	0.63
chr6_159331075_159331226	0.43	ENSG00000223191	.	16453	0.18
chr1_31218807_31218958	0.43	ENSG00000264773	.	6803	0.16
chr1_27951365_27951550	0.43	FGR	feline Gardner-Rasheed sarcoma viral oncogene homolog	884	0.5
chr3_16890725_16890948	0.43	PLCL2	phospholipase C-like 2	35616	0.21
chr10_134359901_134360052	0.42	INPP5A	inositol polyphosphate-5-phosphatase, 40kDa	8333	0.22
chr12_132088912_132089151	0.42	ENSG00000212154	.	56577	0.14
chr22_41597347_41597566	0.41	L3MBTL2	l(3)mbt-like 2 (Drosophila)	3753	0.13
chr11_47942013_47942380	0.41	PTPRJ	protein tyrosine phosphatase, receptor type, J	59917	0.1
chr15_69396582_69396733	0.41	GLCE	glucuronic acid epimerase	56316	0.1
chr2_25557016_25557167	0.41	ENSG00000221445	.	5501	0.23
chr11_65188874_65189025	0.40	ENSG00000245532	.	22980	0.1
chr11_95524026_95524177	0.39	CEP57	centrosomal protein 57kDa	278	0.71
chr17_7743061_7743212	0.38	KDM6B	lysine (K)-specific demethylase 6B	86	0.94
chr20_35258679_35258929	0.38	SLA2	Src-like-adaptor 2	15480	0.12
chr2_84743489_84743817	0.38	DNAH6	dynein, axonemal, heavy chain 6	74	0.98
chr15_45122177_45122328	0.37	ENSG00000238845	.	13558	0.15
chr7_142976503_142976826	0.37	TMEM139	transmembrane protein 139	386	0.73
chr1_165600943_165601210	0.37	MGST3	microsomal glutathione S-transferase 3	224	0.93
chr11_74987512_74987913	0.37	ARRB1	arrestin, beta 1	2031	0.24
chr1_193418439_193418814	0.36	B3GALT2	UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2	262842	0.02
chr19_49134368_49134706	0.36	DBP	D site of albumin promoter (albumin D-box) binding protein	3246	0.1
chr19_55790983_55791283	0.36	HSPBP1	HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1	61	0.93
chr14_91534430_91534736	0.35	C14orf159	chromosome 14 open reading frame 159	7407	0.17
chr11_128495747_128495961	0.35	ETS1	v-ets avian erythroblastosis virus E26 oncogene homolog 1	38401	0.15
chr19_51013763_51014232	0.35	JOSD2	Josephin domain containing 2	348	0.77
chr10_14624151_14624335	0.34	FAM107B	family with sequence similarity 107, member B	9905	0.24
chr16_12173953_12174163	0.34	RP11-276H1.3		10101	0.16
chrY_143427_143587	0.34	NA	NA	> 10⁶	NA
chr2_173329310_173329569	0.34	AC078883.3		1301	0.43
chr12_110721190_110721341	0.34	ATP2A2	ATPase, Ca++ transporting, cardiac muscle, slow twitch 2	1779	0.42
chr11_117746063_117746254	0.34	FXYD6	FXYD domain containing ion transport regulator 6	1182	0.31
chr16_29675395_29675762	0.33	QPRT	quinolinate phosphoribosyltransferase	978	0.33
chr2_28831030_28831181	0.33	PLB1	phospholipase B1	6319	0.24
chr13_46743886_46744372	0.33	ENSG00000240767	.	246	0.88
chr5_110616490_110616674	0.33	AC010468.2		10795	0.21
chr21_46337024_46337254	0.32	ITGB2	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)	2941	0.14
chr1_21672658_21673077	0.32	ECE1	endothelin converting enzyme 1	870	0.66
chr10_22540636_22540794	0.32	EBLN1	endogenous Bornavirus-like nucleoprotein 1	41765	0.14
chr14_20746798_20746965	0.32	CTD-2292M16.7		27008	0.08
chr5_169703034_169703822	0.32	LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	9097	0.23
chr22_20816939_20817099	0.31	ENSG00000255156	.	12579	0.09
chr8_27206009_27206160	0.31	PTK2B	protein tyrosine kinase 2 beta	21744	0.19
chr17_53498413_53498568	0.31	MMD	monocyte to macrophage differentiation-associated	795	0.76
chr2_198745602_198745753	0.31	PLCL1	phospholipase C-like 1	70695	0.11
chr9_75766704_75766963	0.31	ANXA1	annexin A1	15	0.99
chr7_873308_873459	0.31	SUN1	Sad1 and UNC84 domain containing 1	1241	0.44
chr15_64926782_64927086	0.30	ENSG00000207223	.	18153	0.14
chr1_36641142_36641293	0.30	MAP7D1	MAP7 domain containing 1	1101	0.43
chr6_11730922_11731215	0.30	ADTRP	androgen-dependent TFPI-regulating protein	4821	0.27
chr3_127255754_127255970	0.30	TPRA1	transmembrane protein, adipocyte asscociated 1	43418	0.15
chr10_104042307_104042458	0.30	ENSG00000251989	.	21395	0.13
chr17_19265786_19266015	0.30	B9D1	B9 protein domain 1	11	0.96
chr22_35731251_35731492	0.30	ENSG00000266320	.	262	0.91
chr1_32716017_32716330	0.29	LCK	lymphocyte-specific protein tyrosine kinase	667	0.47
chr9_98256224_98256375	0.29	RP11-435O5.6		907	0.55
chr2_8726427_8726645	0.29	AC011747.7		89360	0.09
chr16_88859506_88859657	0.29	PIEZO1	piezo-type mechanosensitive ion channel component 1	7962	0.09
chr1_117305953_117306227	0.29	CD2	CD2 molecule	9001	0.22
chr14_25148564_25148737	0.29	GZMB	granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)	45177	0.13
chr4_111437184_111437430	0.29	RP11-380D23.1		3354	0.3
chr12_96252505_96252656	0.29	RP11-536G4.2		4	0.62
chr16_20952479_20952845	0.29	LYRM1	LYR motif containing 1	40236	0.13
chr2_12596499_12596707	0.29	ENSG00000207183	.	44976	0.2
chr6_91107785_91108329	0.29	ENSG00000252676	.	48434	0.16
chr16_24025609_24025779	0.29	PRKCB	protein kinase C, beta	137312	0.05
chr16_68402502_68402769	0.29	SMPD3	sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)	2273	0.21
chr12_94520148_94520475	0.29	PLXNC1	plexin C1	22188	0.21
chr18_46477254_46477405	0.29	SMAD7	SMAD family member 7	248	0.95
chr2_28836401_28836726	0.29	PLB1	phospholipase B1	11777	0.21
chrX_39337029_39337245	0.28	ENSG00000263730	.	183333	0.03
chr2_235209005_235209246	0.28	ARL4C	ADP-ribosylation factor-like 4C	196119	0.03
chr17_56421421_56421689	0.28	BZRAP1-AS1	BZRAP1 antisense RNA 1	6836	0.11
chr15_102263163_102263772	0.28	TARSL2	threonyl-tRNA synthetase-like 2	1340	0.35
chr11_120895599_120895933	0.28	TBCEL	tubulin folding cofactor E-like	936	0.7
chr11_45407120_45407296	0.28	SYT13	synaptotagmin XIII	99338	0.07
chr8_128313095_128313318	0.28	POU5F1B	POU class 5 homeobox 1B	113329	0.07
chr21_45562160_45562311	0.28	C21orf33	chromosome 21 open reading frame 33	6234	0.16
chr16_17465725_17465877	0.28	XYLT1	xylosyltransferase I	98937	0.09
chr9_45356838_45356989	0.28	AL354718.1	Uncharacterized protein	84629	0.11
chr1_37979556_37979715	0.28	MEAF6	MYST/Esa1-associated factor 6	235	0.9
chr19_55552857_55553277	0.28	GP6	glycoprotein VI (platelet)	3435	0.14
chr4_40239093_40239470	0.27	RHOH	ras homolog family member H	37317	0.16
chr6_35278146_35278341	0.27	DEF6	differentially expressed in FDCP 6 homolog (mouse)	728	0.66
chr1_168391686_168391980	0.27	ENSG00000207974	.	47071	0.16
chr6_41168159_41168310	0.27	TREML2	triggering receptor expressed on myeloid cells-like 2	698	0.58
chr13_48729210_48729361	0.27	MED4	mediator complex subunit 4	60018	0.11
chr1_167598592_167598792	0.27	RCSD1	RCSD domain containing 1	638	0.62
chr2_97504509_97504660	0.27	ANKRD23	ankyrin repeat domain 23	5158	0.14
chr1_111218969_111219120	0.27	KCNA3	potassium voltage-gated channel, shaker-related subfamily, member 3	1389	0.42
chr7_50425689_50425900	0.27	IKZF1	IKAROS family zinc finger 1 (Ikaros)	58549	0.13
chr6_147091501_147091674	0.27	ADGB	androglobin	6	0.99
chr2_136782713_136782864	0.27	AC093391.2		12753	0.23
chr15_74219431_74219582	0.27	LOXL1-AS1	LOXL1 antisense RNA 1	530	0.52
chr13_37632850_37633317	0.27	SUPT20H	suppressor of Ty 20 homolog (S. cerevisiae)	486	0.79
chr22_40781657_40781809	0.27	RP5-1042K10.10		2488	0.24
chr7_50361198_50361353	0.27	IKZF1	IKAROS family zinc finger 1 (Ikaros)	5970	0.31
chr1_233476785_233477065	0.27	MLK4	Mitogen-activated protein kinase kinase kinase MLK4	13411	0.25
chr20_1651387_1651538	0.27	ENSG00000242348	.	4456	0.18
chr8_74884890_74885153	0.27	TCEB1	transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)	499	0.73
chr9_136017473_136017624	0.27	RALGDS	ral guanine nucleotide dissociation stimulator	7173	0.15
chr11_67414259_67414491	0.27	ACY3	aspartoacylase (aminocyclase) 3	679	0.53
chr7_130670944_130671156	0.26	LINC-PINT	long intergenic non-protein coding RNA, p53 induced transcript	2182	0.4
chr3_10708603_10708754	0.26	ATP2B2-IT2	ATP2B2 intronic transcript 2 (non-protein coding)	40186	0.15
chr1_226372867_226373401	0.26	ACBD3	acyl-CoA binding domain containing 3	1297	0.44
chr22_40349969_40350170	0.26	RP3-370M22.8		6332	0.18
chr14_102230041_102230240	0.26	PPP2R5C	protein phosphatase 2, regulatory subunit B', gamma	875	0.57
chr10_121262368_121262551	0.26	RGS10	regulator of G-protein signaling 10	24530	0.21
chr19_50316980_50317131	0.26	FUZ	fuzzy planar cell polarity protein	488	0.55
chr16_29036587_29036789	0.26	CTB-134H23.2	Uncharacterized protein	13235	0.1
chr20_62492653_62492813	0.26	ABHD16B	abhydrolase domain containing 16B	167	0.75
chr2_240169229_240169380	0.26	HDAC4	histone deacetylase 4	56552	0.1
chr17_73530969_73531279	0.26	LLGL2	lethal giant larvae homolog 2 (Drosophila)	2550	0.17
chr22_24824746_24825135	0.26	ADORA2A	adenosine A2a receptor	1410	0.42
chr12_56390912_56391063	0.26	SUOX	sulfite oxidase	23	0.94
chr11_9406722_9407119	0.26	IPO7	importin 7	720	0.66
chr15_31597386_31597537	0.26	KLF13	Kruppel-like factor 13	21597	0.26
chr1_46050680_46050960	0.26	NASP	nuclear autoantigenic sperm protein (histone-binding)	1083	0.46
chr6_109221691_109221882	0.26	ARMC2-AS1	ARMC2 antisense RNA 1	23520	0.19
chrX_117727845_117727996	0.26	ENSG00000206862	.	24442	0.23
chr2_190166860_190167060	0.26	ENSG00000266817	.	9527	0.28
chr3_30932623_30932774	0.26	GADL1	glutamate decarboxylase-like 1	3455	0.38
chr4_38531499_38531667	0.26	RP11-617D20.1		94613	0.08
chr19_20163184_20163440	0.26	ZNF682	zinc finger protein 682	12997	0.16
chr11_4111133_4111394	0.26	RRM1	ribonucleotide reductase M1	4776	0.22
chr10_1195911_1196111	0.26	ADARB2	adenosine deaminase, RNA-specific, B2 (non-functional)	50289	0.13
chr14_96830281_96830470	0.26	ATG2B	autophagy related 2B	168	0.79
chr19_8641468_8641709	0.25	MYO1F	myosin IF	734	0.53
chr8_17101762_17101913	0.25	CNOT7	CCR4-NOT transcription complex, subunit 7	763	0.64
chr11_10878403_10878756	0.25	ZBED5	zinc finger, BED-type containing 5	605	0.6
chr9_134130231_134130385	0.25	FAM78A	family with sequence similarity 78, member A	15572	0.16
chr15_44958521_44958824	0.25	PATL2	protein associated with topoisomerase II homolog 2 (yeast)	2011	0.24
chr1_40526977_40527503	0.25	CAP1	CAP, adenylate cyclase-associated protein 1 (yeast)	20686	0.16
chr7_6298549_6298700	0.25	CYTH3	cytohesin 3	13651	0.18
chr1_9486021_9486424	0.25	ENSG00000252956	.	11615	0.23
chr22_40719595_40719746	0.25	ADSL	adenylosuccinate lyase	22837	0.17
chr9_66493952_66494103	0.25	ENSG00000202474	.	35765	0.24
chr14_72399560_72399713	0.25	RGS6	regulator of G-protein signaling 6	197	0.96
chr19_41814212_41814454	0.25	CCDC97	coiled-coil domain containing 97	1761	0.22
chr9_86881002_86881233	0.25	RP11-380F14.2		12017	0.27
chr22_41865485_41865717	0.25	ACO2	aconitase 2, mitochondrial	467	0.62
chr6_108109017_108109337	0.25	SCML4	sex comb on midleg-like 4 (Drosophila)	15722	0.26
chr14_61190234_61190439	0.25	SIX4	SIX homeobox 4	516	0.81
chr18_74204501_74204708	0.25	RP11-17M16.2		996	0.44
chr6_106565670_106566001	0.25	RP1-134E15.3		17820	0.21
chr1_173992702_173992932	0.25	RC3H1	ring finger and CCCH-type domains 1	1382	0.41
chr13_74834294_74834445	0.25	ENSG00000206617	.	28982	0.24
chr2_74709149_74709337	0.25	CCDC142	coiled-coil domain containing 142	880	0.24
chr7_633791_633942	0.25	PRKAR1B	protein kinase, cAMP-dependent, regulatory, type I, beta	8454	0.17
chr14_65175817_65176316	0.25	PLEKHG3	pleckstrin homology domain containing, family G (with RhoGef domain) member 3	4751	0.25
chr12_123362223_123362374	0.25	VPS37B	vacuolar protein sorting 37 homolog B (S. cerevisiae)	12408	0.16
chr14_77843660_77843811	0.25	SAMD15	sterile alpha motif domain containing 15	259	0.5
chr17_36761272_36761428	0.25	SRCIN1	SRC kinase signaling inhibitor 1	485	0.71
chr6_159065896_159066047	0.25	DYNLT1	dynein, light chain, Tctex-type 1	200	0.94
chr19_50320321_50320721	0.24	FUZ	fuzzy planar cell polarity protein	112	0.87
chrX_106449801_106449952	0.24	PIH1D3	PIH1 domain containing 3	14	0.73
chr13_96330552_96330744	0.24	DNAJC3	DnaJ (Hsp40) homolog, subfamily C, member 3	1236	0.51
chr22_39487886_39488384	0.24	RP4-742C19.12		544	0.68
chr22_23487549_23487700	0.24	RAB36	RAB36, member RAS oncogene family	71	0.84
chr14_104861166_104861551	0.24	ENSG00000222761	.	6027	0.28
chr12_92426979_92427161	0.24	C12orf79	chromosome 12 open reading frame 79	103727	0.07
chr3_51719238_51719389	0.24	ENSG00000201595	.	9285	0.15
chr6_160156842_160156993	0.24	WTAP	Wilms tumor 1 associated protein	8297	0.12
chr16_21946115_21946266	0.24	UQCRC2	ubiquinol-cytochrome c reductase core protein II	17791	0.15
chr12_4244383_4244534	0.24	CCND2	cyclin D2	138480	0.04
chr10_30725176_30725359	0.24	MAP3K8	mitogen-activated protein kinase kinase kinase 8	1673	0.42
chrX_106983960_106984151	0.24	TSC22D3	TSC22 domain family, member 3	18553	0.2
chr9_5593754_5593931	0.24	KIAA1432	KIAA1432	35183	0.19
chr13_100078305_100078553	0.24	ENSG00000266207	.	27294	0.17
chr1_1109206_1109420	0.24	TTLL10	tubulin tyrosine ligase-like family, member 10	27	0.94
chr11_94473539_94473690	0.24	RP11-867G2.8		93	0.98
chr22_40322600_40322763	0.24	GRAP2	GRB2-related adaptor protein 2	40	0.97
chr14_52535018_52535241	0.23	NID2	nidogen 2 (osteonidogen)	583	0.79
chr21_36335819_36335970	0.23	RUNX1	runt-related transcription factor 1	73807	0.13
chr11_60741277_60741428	0.23	CD6	CD6 molecule	2014	0.2
chr11_118747067_118747433	0.23	CXCR5	chemokine (C-X-C motif) receptor 5	7225	0.11
chr2_214148731_214149018	0.23	SPAG16	sperm associated antigen 16	239	0.96
chr1_110798062_110798354	0.23	ENSG00000200536	.	16898	0.14
chr5_156722366_156722517	0.23	CYFIP2	cytoplasmic FMR1 interacting protein 2	10069	0.15

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of RFX7_RFX4_RFX1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0043578	nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.1	0.4	GO:0021898	commitment of multipotent stem cells to neuronal lineage in forebrain(GO:0021898)
0.1	0.4	GO:0031340	positive regulation of vesicle fusion(GO:0031340)
0.1	0.3	GO:0061526	acetylcholine secretion, neurotransmission(GO:0014055) regulation of acetylcholine secretion, neurotransmission(GO:0014056) acetylcholine secretion(GO:0061526)
0.1	0.3	GO:0072216	positive regulation of metanephros development(GO:0072216)
0.1	0.3	GO:0043983	histone H4-K12 acetylation(GO:0043983)
0.1	0.3	GO:0010815	bradykinin catabolic process(GO:0010815)
0.1	0.3	GO:0007100	mitotic centrosome separation(GO:0007100)
0.1	0.3	GO:0051451	myoblast migration(GO:0051451)
0.1	0.2	GO:0071481	cellular response to X-ray(GO:0071481)
0.1	0.1	GO:0010882	regulation of cardiac muscle contraction by calcium ion signaling(GO:0010882)
0.1	0.2	GO:0018094	protein polyglycylation(GO:0018094)
0.1	0.2	GO:0006772	thiamine metabolic process(GO:0006772)
0.1	0.3	GO:0051708	intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) regulation by virus of viral protein levels in host cell(GO:0046719) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708)
0.1	0.3	GO:0015014	heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.1	0.5	GO:0014009	glial cell proliferation(GO:0014009)
0.1	0.2	GO:0060999	positive regulation of dendritic spine development(GO:0060999)
0.1	0.3	GO:0009186	deoxyribonucleoside diphosphate metabolic process(GO:0009186)
0.1	0.2	GO:0007097	nuclear migration(GO:0007097)
0.1	0.2	GO:0042536	negative regulation of tumor necrosis factor biosynthetic process(GO:0042536)
0.1	0.1	GO:0002713	negative regulation of B cell mediated immunity(GO:0002713) negative regulation of immunoglobulin mediated immune response(GO:0002890)
0.1	0.3	GO:0009200	deoxyribonucleoside triphosphate metabolic process(GO:0009200)
0.1	0.2	GO:0050862	positive regulation of T cell receptor signaling pathway(GO:0050862)
0.0	0.1	GO:0071816	protein insertion into ER membrane(GO:0045048) tail-anchored membrane protein insertion into ER membrane(GO:0071816)
0.0	0.1	GO:0035066	positive regulation of histone acetylation(GO:0035066) positive regulation of protein acetylation(GO:1901985) positive regulation of peptidyl-lysine acetylation(GO:2000758)
0.0	0.1	GO:0097709	connective tissue replacement involved in inflammatory response wound healing(GO:0002248) connective tissue replacement(GO:0097709)
0.0	0.1	GO:0014022	neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007)
0.0	0.1	GO:0045990	carbon catabolite regulation of transcription(GO:0045990) regulation of transcription by glucose(GO:0046015)
0.0	0.2	GO:0002691	regulation of cellular extravasation(GO:0002691)
0.0	0.1	GO:0045943	positive regulation of transcription from RNA polymerase I promoter(GO:0045943)
0.0	0.5	GO:0016577	histone demethylation(GO:0016577)
0.0	0.1	GO:0048289	isotype switching to IgE isotypes(GO:0048289) regulation of isotype switching to IgE isotypes(GO:0048293)
0.0	0.3	GO:0010719	negative regulation of epithelial to mesenchymal transition(GO:0010719)
0.0	0.1	GO:0035455	response to interferon-alpha(GO:0035455)
0.0	0.1	GO:2001012	mesenchymal cell differentiation involved in kidney development(GO:0072161) metanephric mesenchymal cell differentiation(GO:0072162) mesenchymal cell differentiation involved in renal system development(GO:2001012)
0.0	0.1	GO:0002313	mature B cell differentiation involved in immune response(GO:0002313)
0.0	1.6	GO:0042384	cilium assembly(GO:0042384)
0.0	0.2	GO:0030174	regulation of DNA-dependent DNA replication initiation(GO:0030174)
0.0	0.1	GO:0002862	negative regulation of inflammatory response to antigenic stimulus(GO:0002862)
0.0	0.2	GO:0002710	negative regulation of T cell mediated immunity(GO:0002710)
0.0	0.1	GO:0070208	protein heterotrimerization(GO:0070208)
0.0	0.2	GO:0070296	sarcoplasmic reticulum calcium ion transport(GO:0070296)
0.0	0.1	GO:0090084	negative regulation of inclusion body assembly(GO:0090084)
0.0	0.2	GO:0033152	immunoglobulin V(D)J recombination(GO:0033152)
0.0	0.1	GO:0015917	aminophospholipid transport(GO:0015917)
0.0	0.1	GO:0090116	DNA methylation on cytosine(GO:0032776) C-5 methylation of cytosine(GO:0090116)
0.0	0.1	GO:0045722	positive regulation of gluconeogenesis(GO:0045722)
0.0	0.2	GO:0030854	positive regulation of granulocyte differentiation(GO:0030854)
0.0	0.1	GO:0060836	lymphatic endothelial cell differentiation(GO:0060836)
0.0	0.0	GO:2000143	negative regulation of transcription initiation from RNA polymerase II promoter(GO:0060633) negative regulation of DNA-templated transcription, initiation(GO:2000143)
0.0	0.2	GO:0002507	tolerance induction(GO:0002507)
0.0	0.1	GO:0006435	threonyl-tRNA aminoacylation(GO:0006435)
0.0	0.1	GO:0046502	uroporphyrinogen III metabolic process(GO:0046502)
0.0	0.0	GO:0021819	cerebral cortex radial glia guided migration(GO:0021801) layer formation in cerebral cortex(GO:0021819) telencephalon glial cell migration(GO:0022030)
0.0	0.1	GO:0031579	membrane raft organization(GO:0031579)
0.0	0.1	GO:0045589	regulation of regulatory T cell differentiation(GO:0045589)
0.0	0.3	GO:0061099	negative regulation of protein tyrosine kinase activity(GO:0061099)
0.0	0.1	GO:0051665	membrane raft localization(GO:0051665)
0.0	0.3	GO:0045749	obsolete negative regulation of S phase of mitotic cell cycle(GO:0045749)
0.0	0.2	GO:0048013	ephrin receptor signaling pathway(GO:0048013)
0.0	0.2	GO:0000389	mRNA 3'-splice site recognition(GO:0000389)
0.0	0.1	GO:0072531	pyrimidine-containing compound transmembrane transport(GO:0072531)
0.0	0.1	GO:0070092	regulation of glucagon secretion(GO:0070092)
0.0	0.0	GO:0002513	tolerance induction to self antigen(GO:0002513)
0.0	0.0	GO:0048319	axial mesoderm morphogenesis(GO:0048319)
0.0	0.1	GO:0048318	axial mesoderm development(GO:0048318)
0.0	0.1	GO:1901970	positive regulation of mitotic metaphase/anaphase transition(GO:0045842) positive regulation of mitotic sister chromatid separation(GO:1901970) positive regulation of metaphase/anaphase transition of cell cycle(GO:1902101)
0.0	0.2	GO:0006546	glycine catabolic process(GO:0006546)
0.0	0.1	GO:0043984	histone H4-K16 acetylation(GO:0043984)
0.0	0.2	GO:0019987	obsolete negative regulation of anti-apoptosis(GO:0019987)
0.0	0.4	GO:0006607	NLS-bearing protein import into nucleus(GO:0006607)
0.0	0.0	GO:0009138	pyrimidine nucleoside diphosphate metabolic process(GO:0009138)
0.0	0.2	GO:0001562	response to protozoan(GO:0001562)
0.0	0.7	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436) positive regulation of proteasomal protein catabolic process(GO:1901800)
0.0	0.1	GO:0021529	spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) oligodendrocyte cell fate specification(GO:0021778) glial cell fate specification(GO:0021780)
0.0	0.1	GO:0006154	adenosine catabolic process(GO:0006154)
0.0	0.1	GO:0002921	negative regulation of humoral immune response(GO:0002921)
0.0	0.2	GO:0000730	DNA recombinase assembly(GO:0000730) double-strand break repair via synthesis-dependent strand annealing(GO:0045003)
0.0	0.2	GO:0045898	regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0	0.1	GO:0043951	negative regulation of cAMP-mediated signaling(GO:0043951)
0.0	0.2	GO:0031061	negative regulation of histone methylation(GO:0031061)
0.0	0.2	GO:0051382	kinetochore assembly(GO:0051382)
0.0	0.0	GO:0032413	negative regulation of ion transmembrane transporter activity(GO:0032413)
0.0	0.1	GO:0032926	negative regulation of activin receptor signaling pathway(GO:0032926)
0.0	0.1	GO:0060708	spongiotrophoblast differentiation(GO:0060708)
0.0	0.1	GO:0010834	obsolete telomere maintenance via telomere shortening(GO:0010834)
0.0	0.3	GO:0007158	neuron cell-cell adhesion(GO:0007158)
0.0	0.1	GO:0008218	bioluminescence(GO:0008218)
0.0	0.2	GO:0046874	quinolinate metabolic process(GO:0046874)
0.0	0.2	GO:0030206	chondroitin sulfate biosynthetic process(GO:0030206)
0.0	0.1	GO:0006167	AMP biosynthetic process(GO:0006167)
0.0	0.0	GO:0021797	forebrain anterior/posterior pattern specification(GO:0021797)
0.0	0.3	GO:0031648	protein destabilization(GO:0031648)
0.0	0.1	GO:0060298	regulation of sarcomere organization(GO:0060297) positive regulation of sarcomere organization(GO:0060298)
0.0	0.0	GO:0051383	kinetochore organization(GO:0051383)
0.0	0.1	GO:0032836	glomerular basement membrane development(GO:0032836)
0.0	0.1	GO:0050765	negative regulation of phagocytosis(GO:0050765)
0.0	0.2	GO:0016553	base conversion or substitution editing(GO:0016553)
0.0	0.1	GO:0006420	arginyl-tRNA aminoacylation(GO:0006420)
0.0	0.1	GO:0030388	fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0	0.1	GO:0048087	positive regulation of developmental pigmentation(GO:0048087)
0.0	0.1	GO:0044340	canonical Wnt signaling pathway involved in regulation of cell proliferation(GO:0044340)
0.0	0.1	GO:0045875	negative regulation of sister chromatid cohesion(GO:0045875)
0.0	0.1	GO:0006922	obsolete cleavage of lamin involved in execution phase of apoptosis(GO:0006922)
0.0	0.1	GO:0060177	regulation of angiotensin levels in blood(GO:0002002) regulation of angiotensin metabolic process(GO:0060177)
0.0	0.1	GO:0021869	forebrain ventricular zone progenitor cell division(GO:0021869)
0.0	0.1	GO:1903504	positive regulation of spindle checkpoint(GO:0090232) regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267) positive regulation of cell cycle checkpoint(GO:1901978) regulation of mitotic spindle checkpoint(GO:1903504)
0.0	0.2	GO:0050858	negative regulation of antigen receptor-mediated signaling pathway(GO:0050858) negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0	0.1	GO:0060218	hematopoietic stem cell differentiation(GO:0060218)
0.0	0.2	GO:0035414	negative regulation of catenin import into nucleus(GO:0035414)
0.0	0.1	GO:0006422	aspartyl-tRNA aminoacylation(GO:0006422)
0.0	0.0	GO:0061339	establishment of apical/basal cell polarity(GO:0035089) establishment of monopolar cell polarity(GO:0061162) establishment or maintenance of monopolar cell polarity(GO:0061339)
0.0	0.1	GO:0031167	rRNA methylation(GO:0031167)
0.0	0.1	GO:0030263	apoptotic chromosome condensation(GO:0030263)
0.0	0.1	GO:0035405	histone-threonine phosphorylation(GO:0035405)
0.0	0.3	GO:0006906	vesicle fusion(GO:0006906)
0.0	0.1	GO:0060676	ureteric bud formation(GO:0060676)
0.0	0.1	GO:0010614	negative regulation of cardiac muscle hypertrophy(GO:0010614)
0.0	0.0	GO:0006667	sphinganine metabolic process(GO:0006667)
0.0	0.2	GO:0009744	response to sucrose(GO:0009744) response to disaccharide(GO:0034285)
0.0	0.3	GO:0045086	positive regulation of interleukin-2 biosynthetic process(GO:0045086)
0.0	0.1	GO:0000301	retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.0	0.2	GO:0008653	lipopolysaccharide metabolic process(GO:0008653)
0.0	0.1	GO:0032790	ribosome disassembly(GO:0032790)
0.0	0.2	GO:0010288	response to lead ion(GO:0010288)
0.0	0.1	GO:0002902	regulation of B cell apoptotic process(GO:0002902) negative regulation of B cell apoptotic process(GO:0002903)
0.0	0.1	GO:0045793	positive regulation of cell size(GO:0045793)
0.0	0.0	GO:2000273	positive regulation of receptor activity(GO:2000273)
0.0	0.1	GO:0015705	iodide transport(GO:0015705)
0.0	0.1	GO:0042492	gamma-delta T cell differentiation(GO:0042492)
0.0	0.1	GO:0043374	CD8-positive, alpha-beta T cell activation(GO:0036037) CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0	0.1	GO:0033033	negative regulation of myeloid cell apoptotic process(GO:0033033)
0.0	0.0	GO:0001783	B cell apoptotic process(GO:0001783)
0.0	0.1	GO:0006610	ribosomal protein import into nucleus(GO:0006610)
0.0	0.1	GO:0010586	miRNA metabolic process(GO:0010586) miRNA catabolic process(GO:0010587)
0.0	0.2	GO:0048505	regulation of development, heterochronic(GO:0040034) regulation of timing of cell differentiation(GO:0048505)
0.0	0.2	GO:0006265	DNA topological change(GO:0006265)
0.0	0.1	GO:0030579	ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0	0.1	GO:0042726	flavin-containing compound metabolic process(GO:0042726)
0.0	0.2	GO:0033687	osteoblast proliferation(GO:0033687)
0.0	0.1	GO:0006857	oligopeptide transport(GO:0006857)
0.0	0.0	GO:0046813	receptor-mediated virion attachment to host cell(GO:0046813)
0.0	0.1	GO:0070071	proton-transporting two-sector ATPase complex assembly(GO:0070071)
0.0	0.1	GO:2001259	positive regulation of calcium ion transmembrane transporter activity(GO:1901021) positive regulation of cation channel activity(GO:2001259)
0.0	0.0	GO:0010592	positive regulation of lamellipodium assembly(GO:0010592) positive regulation of lamellipodium organization(GO:1902745)
0.0	0.1	GO:0032070	regulation of deoxyribonuclease activity(GO:0032070)
0.0	0.1	GO:0097502	protein mannosylation(GO:0035268) protein O-linked mannosylation(GO:0035269) mannosylation(GO:0097502)
0.0	0.0	GO:0010980	regulation of vitamin D 24-hydroxylase activity(GO:0010979) positive regulation of vitamin D 24-hydroxylase activity(GO:0010980)
0.0	0.1	GO:0010957	negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137)
0.0	0.1	GO:0001306	age-dependent response to oxidative stress(GO:0001306) age-dependent general metabolic decline(GO:0007571)
0.0	0.1	GO:0046476	glycosylceramide biosynthetic process(GO:0046476)
0.0	0.2	GO:0040015	negative regulation of multicellular organism growth(GO:0040015)
0.0	0.1	GO:0071480	cellular response to gamma radiation(GO:0071480)
0.0	0.1	GO:0021692	cerebellar Purkinje cell layer morphogenesis(GO:0021692) cerebellar Purkinje cell layer formation(GO:0021694) cerebellar Purkinje cell differentiation(GO:0021702)
0.0	0.0	GO:0032025	response to cobalt ion(GO:0032025)
0.0	0.1	GO:1900619	acetylcholine metabolic process(GO:0008291) acetate ester metabolic process(GO:1900619)
0.0	0.1	GO:0022614	membrane to membrane docking(GO:0022614)
0.0	0.1	GO:0071392	cellular response to estradiol stimulus(GO:0071392)
0.0	0.1	GO:0021903	rostrocaudal neural tube patterning(GO:0021903)
0.0	0.2	GO:0005513	detection of calcium ion(GO:0005513)
0.0	0.0	GO:0032959	inositol trisphosphate biosynthetic process(GO:0032959)
0.0	0.9	GO:0050434	positive regulation of viral transcription(GO:0050434)
0.0	0.0	GO:0003100	regulation of systemic arterial blood pressure by endothelin(GO:0003100)
0.0	0.1	GO:0072577	endothelial cell apoptotic process(GO:0072577) epithelial cell apoptotic process(GO:1904019) regulation of epithelial cell apoptotic process(GO:1904035) regulation of endothelial cell apoptotic process(GO:2000351)
0.0	0.1	GO:0043457	regulation of cellular respiration(GO:0043457)
0.0	0.1	GO:0032486	Rap protein signal transduction(GO:0032486)
0.0	0.1	GO:0070670	response to interleukin-4(GO:0070670)
0.0	0.2	GO:0019059	obsolete initiation of viral infection(GO:0019059)
0.0	0.1	GO:0045603	positive regulation of endothelial cell differentiation(GO:0045603)
0.0	0.1	GO:0045071	negative regulation of viral genome replication(GO:0045071)
0.0	0.1	GO:0071569	protein ufmylation(GO:0071569)
0.0	0.0	GO:0046022	regulation of transcription from RNA polymerase II promoter, mitotic(GO:0046021) positive regulation of transcription from RNA polymerase II promoter during mitosis(GO:0046022)
0.0	0.0	GO:0090174	organelle membrane fusion(GO:0090174)
0.0	0.0	GO:0002707	negative regulation of leukocyte mediated cytotoxicity(GO:0001911) desensitization of G-protein coupled receptor protein signaling pathway by arrestin(GO:0002032) negative regulation of lymphocyte mediated immunity(GO:0002707)
0.0	0.1	GO:0021754	facial nucleus development(GO:0021754)
0.0	0.3	GO:0030968	endoplasmic reticulum unfolded protein response(GO:0030968) cellular response to unfolded protein(GO:0034620)
0.0	0.1	GO:0021527	spinal cord association neuron differentiation(GO:0021527)
0.0	0.1	GO:0030187	melatonin metabolic process(GO:0030186) melatonin biosynthetic process(GO:0030187)
0.0	0.1	GO:0048388	endosomal lumen acidification(GO:0048388)
0.0	0.1	GO:0050849	negative regulation of calcium-mediated signaling(GO:0050849)
0.0	0.1	GO:0000469	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000447) maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462) cleavage involved in rRNA processing(GO:0000469) endonucleolytic cleavage involved in rRNA processing(GO:0000478) endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000479) RNA phosphodiester bond hydrolysis, endonucleolytic(GO:0090502)
0.0	0.0	GO:0003077	obsolete negative regulation of diuresis(GO:0003077)
0.0	0.0	GO:0001672	regulation of chromatin assembly or disassembly(GO:0001672)
0.0	0.1	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress(GO:0070059)
0.0	0.0	GO:0060789	hair follicle placode formation(GO:0060789)
0.0	0.1	GO:0072268	pattern specification involved in metanephros development(GO:0072268)
0.0	0.0	GO:0040023	establishment of nucleus localization(GO:0040023)
0.0	0.1	GO:0032986	nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.0	0.1	GO:0034067	protein localization to Golgi apparatus(GO:0034067)
0.0	0.1	GO:0006547	histidine metabolic process(GO:0006547)
0.0	0.2	GO:0016558	protein import into peroxisome matrix(GO:0016558)
0.0	0.1	GO:0031622	regulation of fever generation(GO:0031620) positive regulation of fever generation(GO:0031622)
0.0	0.1	GO:0048535	lymph node development(GO:0048535)
0.0	0.1	GO:0032236	obsolete positive regulation of calcium ion transport via store-operated calcium channel activity(GO:0032236)
0.0	0.1	GO:0021569	rhombomere 3 development(GO:0021569)
0.0	0.0	GO:0016080	synaptic vesicle targeting(GO:0016080)
0.0	0.0	GO:0002679	respiratory burst involved in defense response(GO:0002679)
0.0	0.3	GO:0045646	regulation of erythrocyte differentiation(GO:0045646)
0.0	0.1	GO:0019885	antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.0	0.1	GO:0006000	fructose metabolic process(GO:0006000)
0.0	0.3	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.0	0.1	GO:0046716	muscle cell cellular homeostasis(GO:0046716)
0.0	0.1	GO:0071108	protein K48-linked deubiquitination(GO:0071108)
0.0	0.2	GO:0006376	mRNA splice site selection(GO:0006376)
0.0	0.0	GO:0002678	regulation of chronic inflammatory response(GO:0002676) positive regulation of chronic inflammatory response(GO:0002678)
0.0	0.1	GO:0033522	histone H2A ubiquitination(GO:0033522)
0.0	0.1	GO:0044803	multi-organism membrane organization(GO:0044803)
0.0	0.3	GO:0000060	protein import into nucleus, translocation(GO:0000060)
0.0	0.2	GO:0042273	ribosomal large subunit biogenesis(GO:0042273)
0.0	0.0	GO:0032808	lacrimal gland development(GO:0032808)
0.0	0.0	GO:0034122	negative regulation of toll-like receptor signaling pathway(GO:0034122)
0.0	0.4	GO:0000289	nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.0	0.1	GO:1903077	negative regulation of establishment of protein localization to plasma membrane(GO:0090005) negative regulation of protein localization to plasma membrane(GO:1903077) negative regulation of protein localization to cell periphery(GO:1904376)
0.0	0.0	GO:0031652	regulation of heat generation(GO:0031650) positive regulation of heat generation(GO:0031652)
0.0	0.2	GO:0033540	fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540)
0.0	0.1	GO:0032057	negative regulation of translational initiation in response to stress(GO:0032057)
0.0	0.0	GO:0050651	dermatan sulfate proteoglycan biosynthetic process(GO:0050651)
0.0	0.0	GO:0043276	anoikis(GO:0043276)
0.0	0.0	GO:0015015	heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0	0.2	GO:0048873	homeostasis of number of cells within a tissue(GO:0048873)
0.0	0.1	GO:0060765	regulation of androgen receptor signaling pathway(GO:0060765)
0.0	0.0	GO:0045824	negative regulation of innate immune response(GO:0045824)
0.0	0.0	GO:0033314	mitotic DNA replication checkpoint(GO:0033314)
0.0	0.0	GO:0060061	Spemann organizer formation(GO:0060061)
0.0	0.1	GO:0002097	tRNA wobble base modification(GO:0002097) tRNA wobble uridine modification(GO:0002098) tRNA thio-modification(GO:0034227)
0.0	0.1	GO:0043584	nose development(GO:0043584)
0.0	0.0	GO:0035054	embryonic heart tube anterior/posterior pattern specification(GO:0035054)
0.0	0.3	GO:0006611	protein export from nucleus(GO:0006611)
0.0	0.0	GO:0015959	diadenosine polyphosphate metabolic process(GO:0015959)
0.0	0.0	GO:0045905	translational frameshifting(GO:0006452) positive regulation of translational elongation(GO:0045901) positive regulation of translational termination(GO:0045905)
0.0	0.0	GO:0006883	cellular sodium ion homeostasis(GO:0006883)
0.0	0.1	GO:0050910	detection of mechanical stimulus involved in sensory perception of sound(GO:0050910)
0.0	0.1	GO:0090205	positive regulation of cholesterol metabolic process(GO:0090205)
0.0	0.0	GO:0002823	negative regulation of adaptive immune response(GO:0002820) negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains(GO:0002823)
0.0	0.0	GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway(GO:0010803)
0.0	0.0	GO:0048302	regulation of isotype switching to IgG isotypes(GO:0048302)
0.0	0.1	GO:0015840	urea transport(GO:0015840)
0.0	0.2	GO:0032092	positive regulation of protein binding(GO:0032092)
0.0	0.2	GO:0071514	genetic imprinting(GO:0071514)
0.0	0.0	GO:0034723	DNA replication-dependent nucleosome organization(GO:0034723)
0.0	0.1	GO:0001782	B cell homeostasis(GO:0001782)
0.0	0.9	GO:0050852	T cell receptor signaling pathway(GO:0050852)
0.0	0.0	GO:0032925	regulation of activin receptor signaling pathway(GO:0032925)
0.0	0.1	GO:0050853	B cell receptor signaling pathway(GO:0050853)
0.0	0.6	GO:0006968	cellular defense response(GO:0006968)
0.0	0.0	GO:0019348	polyprenol metabolic process(GO:0016093) dolichol metabolic process(GO:0019348)
0.0	0.2	GO:0006613	cotranslational protein targeting to membrane(GO:0006613)
0.0	0.1	GO:0051489	regulation of filopodium assembly(GO:0051489)
0.0	0.1	GO:0015904	tetracycline transport(GO:0015904)
0.0	0.0	GO:0060292	long term synaptic depression(GO:0060292)
0.0	0.1	GO:0048268	clathrin coat assembly(GO:0048268)
0.0	0.1	GO:0055070	copper ion homeostasis(GO:0055070)
0.0	0.0	GO:0042511	positive regulation of tyrosine phosphorylation of Stat1 protein(GO:0042511)
0.0	0.1	GO:0016572	histone phosphorylation(GO:0016572)
0.0	0.1	GO:0071347	cellular response to interleukin-1(GO:0071347)
0.0	0.1	GO:0007029	endoplasmic reticulum organization(GO:0007029)
0.0	0.2	GO:0006400	tRNA modification(GO:0006400)
0.0	0.1	GO:0048496	maintenance of organ identity(GO:0048496)
0.0	0.0	GO:0061030	epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.0	0.0	GO:2000516	positive regulation of CD4-positive, alpha-beta T cell differentiation(GO:0043372) positive regulation of CD4-positive, alpha-beta T cell activation(GO:2000516)
0.0	0.0	GO:0090400	stress-induced premature senescence(GO:0090400)
0.0	0.1	GO:0009253	peptidoglycan metabolic process(GO:0000270) peptidoglycan catabolic process(GO:0009253)
0.0	0.1	GO:0006379	mRNA cleavage(GO:0006379)
0.0	0.0	GO:0072180	mesonephric duct morphogenesis(GO:0072180)
0.0	0.0	GO:0016242	regulation of macroautophagy(GO:0016241) negative regulation of macroautophagy(GO:0016242)
0.0	0.3	GO:0035337	fatty-acyl-CoA metabolic process(GO:0035337)
0.0	0.0	GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway(GO:0007195)
0.0	0.1	GO:0042541	hemoglobin biosynthetic process(GO:0042541)
0.0	0.0	GO:0031665	regulation of lipopolysaccharide-mediated signaling pathway(GO:0031664) negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.0	0.1	GO:0009304	tRNA transcription(GO:0009304)
0.0	0.0	GO:0043117	positive regulation of vascular permeability(GO:0043117)
0.0	0.0	GO:0045354	interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354) positive regulation of interferon-alpha biosynthetic process(GO:0045356)
0.0	0.1	GO:1901072	amino sugar catabolic process(GO:0046348) glucosamine-containing compound catabolic process(GO:1901072)
0.0	0.0	GO:0010452	histone H3-K36 methylation(GO:0010452)
0.0	0.1	GO:0032456	endocytic recycling(GO:0032456)
0.0	0.1	GO:0071157	negative regulation of cell cycle arrest(GO:0071157)
0.0	0.0	GO:0060159	regulation of dopamine receptor signaling pathway(GO:0060159)
0.0	0.1	GO:0031115	negative regulation of microtubule polymerization(GO:0031115)
0.0	0.0	GO:0001866	NK T cell proliferation(GO:0001866)
0.0	0.3	GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway(GO:0042059) negative regulation of ERBB signaling pathway(GO:1901185)
0.0	0.1	GO:0051568	histone H3-K4 methylation(GO:0051568)
0.0	0.1	GO:0043496	regulation of protein homodimerization activity(GO:0043496)
0.0	0.0	GO:0001661	conditioned taste aversion(GO:0001661)
0.0	0.0	GO:0002323	natural killer cell activation involved in immune response(GO:0002323) natural killer cell degranulation(GO:0043320)
0.0	0.0	GO:0042494	detection of bacterial lipoprotein(GO:0042494) detection of bacterial lipopeptide(GO:0070340)
0.0	0.1	GO:0050667	homocysteine metabolic process(GO:0050667)
0.0	0.0	GO:0006290	pyrimidine dimer repair(GO:0006290)
0.0	0.0	GO:0033119	negative regulation of RNA splicing(GO:0033119)
0.0	0.0	GO:0071391	cellular response to estrogen stimulus(GO:0071391)
0.0	0.2	GO:0006298	mismatch repair(GO:0006298)
0.0	0.0	GO:0007191	adenylate cyclase-activating dopamine receptor signaling pathway(GO:0007191)
0.0	0.0	GO:0045910	negative regulation of DNA recombination(GO:0045910)
0.0	0.2	GO:0050690	regulation of defense response to virus by virus(GO:0050690)
0.0	0.0	GO:0042501	serine phosphorylation of STAT protein(GO:0042501)
0.0	0.1	GO:0042104	positive regulation of activated T cell proliferation(GO:0042104) regulation of activated T cell proliferation(GO:0046006)
0.0	0.1	GO:0042989	sequestering of actin monomers(GO:0042989)
0.0	0.1	GO:0060040	retinal bipolar neuron differentiation(GO:0060040)
0.0	0.0	GO:0051294	establishment of mitotic spindle orientation(GO:0000132) establishment of spindle orientation(GO:0051294)
0.0	0.0	GO:0030889	negative regulation of B cell proliferation(GO:0030889)
0.0	0.1	GO:0045948	positive regulation of translational initiation(GO:0045948)
0.0	0.1	GO:0001820	serotonin secretion(GO:0001820)
0.0	0.1	GO:0007035	vacuolar acidification(GO:0007035)
0.0	0.0	GO:0048711	positive regulation of astrocyte differentiation(GO:0048711)
0.0	0.2	GO:0006359	regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.0	0.1	GO:0061097	regulation of protein tyrosine kinase activity(GO:0061097)
0.0	0.0	GO:0001991	regulation of systemic arterial blood pressure by circulatory renin-angiotensin(GO:0001991)
0.0	0.1	GO:0032007	negative regulation of TOR signaling(GO:0032007)
0.0	0.0	GO:0045906	negative regulation of vasoconstriction(GO:0045906)
0.0	0.0	GO:0072583	synaptic vesicle recycling(GO:0036465) synaptic vesicle endocytosis(GO:0048488) clathrin-mediated endocytosis(GO:0072583)
0.0	0.0	GO:0051965	positive regulation of synapse assembly(GO:0051965)
0.0	0.1	GO:0046854	phosphatidylinositol phosphorylation(GO:0046854)
0.0	0.1	GO:0018026	peptidyl-lysine monomethylation(GO:0018026)
0.0	0.1	GO:0071600	otic vesicle formation(GO:0030916) otic vesicle development(GO:0071599) otic vesicle morphogenesis(GO:0071600)
0.0	0.1	GO:0061088	regulation of sequestering of zinc ion(GO:0061088)
0.0	0.0	GO:0072383	plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.0	0.1	GO:0006491	N-glycan processing(GO:0006491)
0.0	0.0	GO:0021860	pyramidal neuron differentiation(GO:0021859) pyramidal neuron development(GO:0021860)
0.0	0.1	GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737) positive regulation of cyclin-dependent protein kinase activity(GO:1904031)
0.0	0.0	GO:0051503	adenine nucleotide transport(GO:0051503)
0.0	0.0	GO:0040016	embryonic cleavage(GO:0040016)
0.0	0.0	GO:0009405	pathogenesis(GO:0009405)
0.0	0.0	GO:0000154	rRNA modification(GO:0000154)
0.0	0.0	GO:0015825	L-serine transport(GO:0015825)
0.0	0.1	GO:0008655	pyrimidine-containing compound salvage(GO:0008655) pyrimidine nucleoside salvage(GO:0043097)
0.0	0.2	GO:0043044	ATP-dependent chromatin remodeling(GO:0043044)
0.0	0.0	GO:0045292	mRNA cis splicing, via spliceosome(GO:0045292)
0.0	0.0	GO:0045579	positive regulation of B cell differentiation(GO:0045579)
0.0	0.0	GO:0046958	nonassociative learning(GO:0046958)
0.0	0.0	GO:0050851	antigen receptor-mediated signaling pathway(GO:0050851)
0.0	0.0	GO:0009822	alkaloid catabolic process(GO:0009822)
0.0	0.1	GO:0032008	positive regulation of TOR signaling(GO:0032008)
0.0	0.0	GO:0042339	keratan sulfate metabolic process(GO:0042339)
0.0	0.0	GO:0006998	nuclear envelope organization(GO:0006998)
0.0	0.1	GO:0043666	regulation of phosphoprotein phosphatase activity(GO:0043666)
0.0	0.1	GO:0002286	T cell activation involved in immune response(GO:0002286)
0.0	0.0	GO:0018343	protein farnesylation(GO:0018343)
0.0	0.1	GO:0006686	sphingomyelin biosynthetic process(GO:0006686)
0.0	0.0	GO:0007256	activation of JNKK activity(GO:0007256)
0.0	0.0	GO:0051319	mitotic G2 phase(GO:0000085) G2 phase(GO:0051319)
0.0	0.0	GO:0032277	regulation of gonadotropin secretion(GO:0032276) negative regulation of gonadotropin secretion(GO:0032277)
0.0	0.1	GO:0007635	chemosensory behavior(GO:0007635)
0.0	0.0	GO:0009048	dosage compensation by inactivation of X chromosome(GO:0009048)
0.0	0.0	GO:0044818	mitotic G2 DNA damage checkpoint(GO:0007095) mitotic G2/M transition checkpoint(GO:0044818)
0.0	0.0	GO:0017183	peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.0	0.6	GO:0031571	mitotic G1 DNA damage checkpoint(GO:0031571) G1 DNA damage checkpoint(GO:0044783) mitotic G1/S transition checkpoint(GO:0044819) negative regulation of cell cycle G1/S phase transition(GO:1902807) negative regulation of G1/S transition of mitotic cell cycle(GO:2000134)
0.0	0.0	GO:0009263	deoxyribonucleotide biosynthetic process(GO:0009263)
0.0	0.0	GO:0015853	adenine transport(GO:0015853)
0.0	0.0	GO:0046548	retinal rod cell development(GO:0046548)
0.0	0.0	GO:0042532	negative regulation of tyrosine phosphorylation of STAT protein(GO:0042532)
0.0	0.1	GO:0035305	negative regulation of dephosphorylation(GO:0035305) negative regulation of protein dephosphorylation(GO:0035308)
0.0	0.1	GO:0006685	sphingomyelin catabolic process(GO:0006685)
0.0	0.1	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity(GO:0045197)
0.0	0.0	GO:0072079	nephron tubule formation(GO:0072079)
0.0	0.0	GO:0021542	dentate gyrus development(GO:0021542)
0.0	0.0	GO:0008053	mitochondrial fusion(GO:0008053)
0.0	0.1	GO:0016180	snRNA processing(GO:0016180)
0.0	0.1	GO:0007099	centriole replication(GO:0007099) centriole assembly(GO:0098534)
0.0	0.0	GO:0001880	Mullerian duct regression(GO:0001880)
0.0	0.0	GO:0032411	positive regulation of transporter activity(GO:0032411)
0.0	0.0	GO:0000012	single strand break repair(GO:0000012)
0.0	0.0	GO:0007089	traversing start control point of mitotic cell cycle(GO:0007089) positive regulation of G1/S transition of mitotic cell cycle(GO:1900087) positive regulation of cell cycle G1/S phase transition(GO:1902808)
0.0	0.0	GO:0031936	negative regulation of chromatin silencing(GO:0031936)
0.0	0.0	GO:0060632	regulation of microtubule-based movement(GO:0060632)
0.0	0.0	GO:1901186	positive regulation of epidermal growth factor receptor signaling pathway(GO:0045742) positive regulation of ERBB signaling pathway(GO:1901186)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.9	GO:0034518	mRNA cap binding complex(GO:0005845) RNA cap binding complex(GO:0034518)
0.1	0.3	GO:0031205	endoplasmic reticulum Sec complex(GO:0031205)
0.1	0.4	GO:0034992	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.1	0.2	GO:0031235	intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.1	0.2	GO:0048179	activin receptor complex(GO:0048179)
0.1	0.2	GO:0042105	alpha-beta T cell receptor complex(GO:0042105)
0.1	0.3	GO:0070776	H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.1	0.3	GO:0042827	platelet dense granule(GO:0042827)
0.0	0.1	GO:0072379	BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.0	0.1	GO:1903561	extracellular exosome(GO:0070062) extracellular vesicle(GO:1903561)
0.0	0.5	GO:0005858	axonemal dynein complex(GO:0005858)
0.0	0.2	GO:0000137	Golgi cis cisterna(GO:0000137)
0.0	0.4	GO:0016585	obsolete chromatin remodeling complex(GO:0016585)
0.0	0.1	GO:0043625	delta DNA polymerase complex(GO:0043625)
0.0	0.1	GO:0070852	cell body fiber(GO:0070852)
0.0	0.2	GO:0031254	uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0	0.2	GO:0044224	juxtaparanode region of axon(GO:0044224)
0.0	0.3	GO:0016342	catenin complex(GO:0016342)
0.0	0.1	GO:0072487	MSL complex(GO:0072487)
0.0	0.3	GO:0005868	cytoplasmic dynein complex(GO:0005868)
0.0	0.1	GO:0001652	granular component(GO:0001652)
0.0	0.1	GO:0005826	actomyosin contractile ring(GO:0005826)
0.0	0.1	GO:0000138	Golgi trans cisterna(GO:0000138)
0.0	0.2	GO:0032279	asymmetric synapse(GO:0032279) neuron to neuron synapse(GO:0098984)
0.0	0.0	GO:0070938	contractile ring(GO:0070938)
0.0	0.3	GO:0001772	immunological synapse(GO:0001772)
0.0	0.1	GO:0030904	retromer complex(GO:0030904)
0.0	0.2	GO:0001891	phagocytic cup(GO:0001891)
0.0	0.2	GO:0042101	T cell receptor complex(GO:0042101)
0.0	0.2	GO:0031095	platelet dense tubular network membrane(GO:0031095)
0.0	0.1	GO:0043218	compact myelin(GO:0043218)
0.0	1.0	GO:0005930	axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.0	0.1	GO:0005883	neurofilament(GO:0005883)
0.0	0.5	GO:0032155	cell division site(GO:0032153) cleavage furrow(GO:0032154) cell division site part(GO:0032155) cell surface furrow(GO:0097610)
0.0	0.1	GO:0072357	PTW/PP1 phosphatase complex(GO:0072357)
0.0	0.1	GO:0005899	insulin receptor complex(GO:0005899)
0.0	0.1	GO:0033185	mannosyltransferase complex(GO:0031501) dolichol-phosphate-mannose synthase complex(GO:0033185)
0.0	0.1	GO:0034451	centriolar satellite(GO:0034451)
0.0	0.1	GO:0002080	acrosomal membrane(GO:0002080)
0.0	0.4	GO:0005844	polysome(GO:0005844)
0.0	0.4	GO:0000159	protein phosphatase type 2A complex(GO:0000159)
0.0	0.1	GO:0071778	obsolete WINAC complex(GO:0071778)
0.0	0.1	GO:0000791	euchromatin(GO:0000791)
0.0	0.1	GO:0005686	U2 snRNP(GO:0005686)
0.0	0.1	GO:0005662	DNA replication factor A complex(GO:0005662)
0.0	0.1	GO:0016461	unconventional myosin complex(GO:0016461)
0.0	0.1	GO:0031428	box C/D snoRNP complex(GO:0031428)
0.0	0.2	GO:0010494	cytoplasmic stress granule(GO:0010494)
0.0	0.1	GO:0071564	npBAF complex(GO:0071564)
0.0	0.1	GO:0042583	chromaffin granule(GO:0042583) chromaffin granule membrane(GO:0042584)
0.0	0.1	GO:0032585	multivesicular body membrane(GO:0032585)
0.0	0.1	GO:0032391	photoreceptor connecting cilium(GO:0032391)
0.0	0.1	GO:0031616	spindle pole centrosome(GO:0031616)
0.0	0.2	GO:0030877	beta-catenin destruction complex(GO:0030877)
0.0	0.1	GO:0031045	dense core granule(GO:0031045)
0.0	0.2	GO:0042555	MCM complex(GO:0042555)
0.0	0.1	GO:0031143	pseudopodium(GO:0031143)
0.0	0.7	GO:0036064	ciliary basal body(GO:0036064)
0.0	0.1	GO:0030008	TRAPP complex(GO:0030008)
0.0	0.2	GO:0031231	integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.0	0.2	GO:0005732	small nucleolar ribonucleoprotein complex(GO:0005732)
0.0	0.1	GO:0005683	U7 snRNP(GO:0005683)
0.0	0.1	GO:0000109	nucleotide-excision repair complex(GO:0000109)
0.0	0.1	GO:0042824	MHC class I peptide loading complex(GO:0042824)
0.0	0.3	GO:0005892	acetylcholine-gated channel complex(GO:0005892)
0.0	0.2	GO:0000421	autophagosome membrane(GO:0000421)
0.0	0.2	GO:0008180	COP9 signalosome(GO:0008180)
0.0	0.1	GO:0070419	nonhomologous end joining complex(GO:0070419)
0.0	0.0	GO:0032593	insulin-responsive compartment(GO:0032593)
0.0	0.0	GO:0030895	apolipoprotein B mRNA editing enzyme complex(GO:0030895)
0.0	0.1	GO:0019907	cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
0.0	0.0	GO:0005945	6-phosphofructokinase complex(GO:0005945)
0.0	0.1	GO:0048500	signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.0	0.1	GO:0000800	lateral element(GO:0000800)
0.0	0.2	GO:0034362	low-density lipoprotein particle(GO:0034362)
0.0	0.5	GO:0005626	obsolete insoluble fraction(GO:0005626)
0.0	0.0	GO:0014731	spectrin-associated cytoskeleton(GO:0014731)
0.0	0.0	GO:0005850	eukaryotic translation initiation factor 2 complex(GO:0005850)
0.0	0.3	GO:0046658	anchored component of plasma membrane(GO:0046658)
0.0	0.0	GO:0009331	glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.0	0.1	GO:0019773	proteasome core complex, alpha-subunit complex(GO:0019773)
0.0	0.2	GO:0030530	obsolete heterogeneous nuclear ribonucleoprotein complex(GO:0030530)
0.0	0.1	GO:0016589	NURF complex(GO:0016589)
0.0	0.1	GO:0090576	RNA polymerase III transcription factor complex(GO:0090576)
0.0	0.0	GO:0071817	MMXD complex(GO:0071817)
0.0	0.1	GO:0005675	holo TFIIH complex(GO:0005675)
0.0	0.1	GO:0030897	HOPS complex(GO:0030897)
0.0	0.6	GO:0031902	late endosome membrane(GO:0031902)
0.0	0.3	GO:0001533	cornified envelope(GO:0001533)
0.0	0.5	GO:0005758	mitochondrial intermembrane space(GO:0005758)
0.0	0.1	GO:0030870	Mre11 complex(GO:0030870)
0.0	0.1	GO:0042589	zymogen granule membrane(GO:0042589)
0.0	0.1	GO:0000242	pericentriolar material(GO:0000242)
0.0	0.1	GO:0005869	dynactin complex(GO:0005869)
0.0	0.4	GO:0016592	mediator complex(GO:0016592)
0.0	0.2	GO:0030137	COPI-coated vesicle(GO:0030137)
0.0	0.2	GO:0031519	PcG protein complex(GO:0031519)
0.0	0.1	GO:0032588	trans-Golgi network membrane(GO:0032588)
0.0	0.0	GO:0045323	interleukin-1 receptor complex(GO:0045323)
0.0	0.1	GO:0045275	mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.0	0.0	GO:0005947	mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947)
0.0	0.0	GO:0071438	invadopodium membrane(GO:0071438)
0.0	0.0	GO:0032299	ribonuclease H2 complex(GO:0032299)
0.0	0.1	GO:0005664	origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.0	0.1	GO:0008290	F-actin capping protein complex(GO:0008290)
0.0	0.3	GO:0005834	heterotrimeric G-protein complex(GO:0005834)
0.0	0.0	GO:0044462	external encapsulating structure(GO:0030312) external encapsulating structure part(GO:0044462)
0.0	0.1	GO:0005665	DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0	0.1	GO:0042382	paraspeckles(GO:0042382)
0.0	0.1	GO:0031528	microvillus membrane(GO:0031528)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0008321	Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.1	0.3	GO:0019834	phospholipase A2 inhibitor activity(GO:0019834)
0.1	0.2	GO:0030151	molybdenum ion binding(GO:0030151)
0.1	0.2	GO:0050508	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.1	0.2	GO:0070735	protein-glycine ligase activity(GO:0070735)
0.1	0.3	GO:0048018	receptor agonist activity(GO:0048018)
0.1	0.2	GO:0050253	retinyl-palmitate esterase activity(GO:0050253)
0.1	0.2	GO:0005025	transforming growth factor beta receptor activity, type I(GO:0005025)
0.1	0.2	GO:0003701	obsolete RNA polymerase I transcription factor activity(GO:0003701)
0.1	0.2	GO:0070579	methylcytosine dioxygenase activity(GO:0070579)
0.1	0.2	GO:0004465	lipoprotein lipase activity(GO:0004465)
0.1	0.2	GO:0003726	double-stranded RNA adenosine deaminase activity(GO:0003726)
0.1	0.5	GO:0005388	calcium-transporting ATPase activity(GO:0005388)
0.0	0.2	GO:0003986	acetyl-CoA hydrolase activity(GO:0003986)
0.0	0.2	GO:0004046	aminoacylase activity(GO:0004046)
0.0	0.3	GO:0016494	C-X-C chemokine receptor activity(GO:0016494)
0.0	0.1	GO:0047631	ADP-ribose diphosphatase activity(GO:0047631)
0.0	0.1	GO:0061731	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.0	0.3	GO:0008266	poly(U) RNA binding(GO:0008266)
0.0	0.2	GO:0003917	DNA topoisomerase type I activity(GO:0003917)
0.0	0.3	GO:0001609	G-protein coupled adenosine receptor activity(GO:0001609)
0.0	0.1	GO:0042806	fucose binding(GO:0042806)
0.0	0.1	GO:0004332	fructose-bisphosphate aldolase activity(GO:0004332)
0.0	0.2	GO:0004047	aminomethyltransferase activity(GO:0004047)
0.0	0.1	GO:0004514	nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514)
0.0	0.1	GO:0004829	threonine-tRNA ligase activity(GO:0004829)
0.0	0.1	GO:0043533	inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.0	0.4	GO:0005251	delayed rectifier potassium channel activity(GO:0005251)
0.0	0.1	GO:0033829	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.0	0.1	GO:0016309	1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0	0.2	GO:0019211	phosphatase activator activity(GO:0019211)
0.0	0.3	GO:0015278	calcium-release channel activity(GO:0015278) ligand-gated calcium channel activity(GO:0099604)
0.0	0.1	GO:0004477	methenyltetrahydrofolate cyclohydrolase activity(GO:0004477)
0.0	0.5	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0	0.0	GO:0031957	very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0	0.3	GO:0016493	C-C chemokine receptor activity(GO:0016493)
0.0	0.2	GO:0047429	nucleoside-triphosphate diphosphatase activity(GO:0047429)
0.0	0.3	GO:0051787	misfolded protein binding(GO:0051787)
0.0	0.0	GO:0000400	four-way junction DNA binding(GO:0000400)
0.0	0.4	GO:0070064	proline-rich region binding(GO:0070064)
0.0	0.1	GO:0004301	epoxide hydrolase activity(GO:0004301)
0.0	0.1	GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717)
0.0	0.1	GO:0047756	chondroitin 4-sulfotransferase activity(GO:0047756)
0.0	0.1	GO:0016842	amidine-lyase activity(GO:0016842)
0.0	0.1	GO:0030306	ADP-ribosylation factor binding(GO:0030306)
0.0	0.1	GO:0004814	arginine-tRNA ligase activity(GO:0004814)
0.0	0.2	GO:0005521	lamin binding(GO:0005521)
0.0	0.2	GO:0005092	GDP-dissociation inhibitor activity(GO:0005092)
0.0	0.1	GO:0008745	N-acetylmuramoyl-L-alanine amidase activity(GO:0008745)
0.0	0.1	GO:0042156	obsolete zinc-mediated transcriptional activator activity(GO:0042156)
0.0	0.1	GO:0031685	adenosine receptor binding(GO:0031685)
0.0	0.1	GO:0004583	dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity(GO:0004583)
0.0	0.1	GO:0016520	growth hormone-releasing hormone receptor activity(GO:0016520)
0.0	0.1	GO:0017081	chloride channel regulator activity(GO:0017081)
0.0	0.9	GO:0004601	peroxidase activity(GO:0004601) oxidoreductase activity, acting on peroxide as acceptor(GO:0016684)
0.0	0.2	GO:0016417	S-acyltransferase activity(GO:0016417)
0.0	0.1	GO:0098599	palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0	0.2	GO:0016778	diphosphotransferase activity(GO:0016778)
0.0	0.1	GO:0035184	histone threonine kinase activity(GO:0035184)
0.0	0.1	GO:0004591	oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.0	0.1	GO:0052813	phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.0	0.6	GO:0003727	single-stranded RNA binding(GO:0003727)
0.0	0.1	GO:0004802	transketolase activity(GO:0004802)
0.0	0.3	GO:0004467	long-chain fatty acid-CoA ligase activity(GO:0004467)
0.0	0.2	GO:0051019	mitogen-activated protein kinase binding(GO:0051019)
0.0	0.3	GO:0019206	nucleoside kinase activity(GO:0019206)
0.0	0.1	GO:0008384	IkappaB kinase activity(GO:0008384)
0.0	0.4	GO:0043621	protein self-association(GO:0043621)
0.0	0.2	GO:0001848	complement binding(GO:0001848)
0.0	0.1	GO:0008420	CTD phosphatase activity(GO:0008420)
0.0	0.1	GO:0022897	peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897)
0.0	0.2	GO:0004859	phospholipase inhibitor activity(GO:0004859)
0.0	0.3	GO:0003709	obsolete RNA polymerase III transcription factor activity(GO:0003709)
0.0	1.1	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)
0.0	0.3	GO:0008239	dipeptidyl-peptidase activity(GO:0008239)
0.0	0.5	GO:0001608	G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0	0.0	GO:0003872	6-phosphofructokinase activity(GO:0003872)
0.0	0.1	GO:0004075	biotin carboxylase activity(GO:0004075)
0.0	0.1	GO:0047238	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.0	0.1	GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0	0.1	GO:0015925	galactosidase activity(GO:0015925)
0.0	0.1	GO:0005275	amine transmembrane transporter activity(GO:0005275)
0.0	0.0	GO:0003960	NADPH:quinone reductase activity(GO:0003960)
0.0	0.1	GO:0005113	patched binding(GO:0005113)
0.0	0.1	GO:0003886	DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0	0.1	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0	0.2	GO:0046870	cadmium ion binding(GO:0046870)
0.0	0.1	GO:0004582	dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582)
0.0	0.2	GO:0031701	angiotensin receptor binding(GO:0031701)
0.0	0.1	GO:0042608	T cell receptor binding(GO:0042608)
0.0	0.9	GO:0004715	non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0	0.1	GO:0008898	S-adenosylmethionine-homocysteine S-methyltransferase activity(GO:0008898)
0.0	0.1	GO:0008486	diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486)
0.0	0.1	GO:0004619	bisphosphoglycerate mutase activity(GO:0004082) bisphosphoglycerate 2-phosphatase activity(GO:0004083) phosphoglycerate mutase activity(GO:0004619)
0.0	0.1	GO:0004062	aryl sulfotransferase activity(GO:0004062)
0.0	0.3	GO:0048365	Rac GTPase binding(GO:0048365)
0.0	0.2	GO:0050700	CARD domain binding(GO:0050700)
0.0	0.3	GO:0004697	protein kinase C activity(GO:0004697)
0.0	0.2	GO:0046875	ephrin receptor binding(GO:0046875)
0.0	0.1	GO:0015165	pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.0	0.1	GO:0050815	phosphoserine binding(GO:0050815)
0.0	0.1	GO:0015204	urea transmembrane transporter activity(GO:0015204)
0.0	0.1	GO:0032139	dinucleotide insertion or deletion binding(GO:0032139)
0.0	0.1	GO:0050733	RS domain binding(GO:0050733)
0.0	0.4	GO:0008601	protein phosphatase type 2A regulator activity(GO:0008601)
0.0	0.0	GO:0004706	JUN kinase kinase kinase activity(GO:0004706)
0.0	0.1	GO:0001727	lipid kinase activity(GO:0001727)
0.0	1.0	GO:0003743	translation initiation factor activity(GO:0003743)
0.0	0.1	GO:0016423	tRNA (guanine) methyltransferase activity(GO:0016423)
0.0	0.1	GO:0004449	isocitrate dehydrogenase (NAD+) activity(GO:0004449)
0.0	0.1	GO:0070996	type 1 melanocortin receptor binding(GO:0070996)
0.0	0.1	GO:0030292	protein tyrosine kinase inhibitor activity(GO:0030292)
0.0	0.1	GO:0030898	actin-dependent ATPase activity(GO:0030898)
0.0	0.1	GO:0004307	ethanolaminephosphotransferase activity(GO:0004307)
0.0	0.1	GO:0001517	N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517)
0.0	0.2	GO:0008536	Ran GTPase binding(GO:0008536)
0.0	0.1	GO:0004775	succinate-CoA ligase (ADP-forming) activity(GO:0004775)
0.0	0.0	GO:0070644	vitamin D response element binding(GO:0070644)
0.0	0.1	GO:0015520	tetracycline:proton antiporter activity(GO:0015520)
0.0	0.1	GO:0005549	odorant binding(GO:0005549)
0.0	0.1	GO:0052658	inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658) inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity(GO:0052659)
0.0	0.1	GO:0061630	ubiquitin-ubiquitin ligase activity(GO:0034450) ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659)
0.0	0.1	GO:0017056	structural constituent of nuclear pore(GO:0017056)
0.0	0.0	GO:0045118	azole transporter activity(GO:0045118) azole transmembrane transporter activity(GO:1901474)
0.0	0.0	GO:0035197	siRNA binding(GO:0035197)
0.0	0.0	GO:0003985	acetyl-CoA C-acetyltransferase activity(GO:0003985)
0.0	0.1	GO:0046977	TAP binding(GO:0046977) TAP1 binding(GO:0046978) TAP2 binding(GO:0046979)
0.0	0.1	GO:0016208	AMP binding(GO:0016208)
0.0	0.2	GO:0046527	glucosyltransferase activity(GO:0046527)
0.0	0.1	GO:0004691	cAMP-dependent protein kinase activity(GO:0004691)
0.0	0.1	GO:0070215	obsolete MDM2 binding(GO:0070215)
0.0	0.1	GO:0030368	interleukin-17 receptor activity(GO:0030368)
0.0	0.2	GO:0016408	C-acyltransferase activity(GO:0016408)
0.0	0.1	GO:0004300	enoyl-CoA hydratase activity(GO:0004300)
0.0	0.1	GO:0004677	DNA-dependent protein kinase activity(GO:0004677)
0.0	0.1	GO:0008312	7S RNA binding(GO:0008312)
0.0	0.2	GO:0019894	kinesin binding(GO:0019894)
0.0	0.0	GO:0015349	thyroid hormone transmembrane transporter activity(GO:0015349)
0.0	0.0	GO:0008518	reduced folate carrier activity(GO:0008518)
0.0	0.0	GO:0031782	melanocortin receptor binding(GO:0031779) type 3 melanocortin receptor binding(GO:0031781) type 4 melanocortin receptor binding(GO:0031782)
0.0	0.1	GO:0003706	obsolete ligand-regulated transcription factor activity(GO:0003706)
0.0	0.1	GO:0031014	troponin T binding(GO:0031014)
0.0	0.0	GO:0004607	phosphatidylcholine-sterol O-acyltransferase activity(GO:0004607)
0.0	1.2	GO:0003777	microtubule motor activity(GO:0003777)
0.0	0.2	GO:0004709	MAP kinase kinase kinase activity(GO:0004709)
0.0	0.1	GO:0005522	profilin binding(GO:0005522)
0.0	0.3	GO:0003730	mRNA 3'-UTR binding(GO:0003730)
0.0	0.2	GO:0017134	fibroblast growth factor binding(GO:0017134)
0.0	0.1	GO:0070567	cytidylyltransferase activity(GO:0070567)
0.0	0.2	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0	0.2	GO:0004889	acetylcholine-activated cation-selective channel activity(GO:0004889)
0.0	0.1	GO:0030507	spectrin binding(GO:0030507)
0.0	0.2	GO:0005095	GTPase inhibitor activity(GO:0005095)
0.0	0.1	GO:0004032	alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.0	0.0	GO:0050265	RNA uridylyltransferase activity(GO:0050265)
0.0	0.0	GO:0050501	hyaluronan synthase activity(GO:0050501)
0.0	0.1	GO:0003691	double-stranded telomeric DNA binding(GO:0003691)
0.0	0.0	GO:0004735	pyrroline-5-carboxylate reductase activity(GO:0004735)
0.0	0.0	GO:0031849	olfactory receptor binding(GO:0031849)
0.0	0.0	GO:0033691	sialic acid binding(GO:0033691)
0.0	0.0	GO:0004367	glycerol-3-phosphate dehydrogenase [NAD+] activity(GO:0004367)
0.0	0.0	GO:0016286	small conductance calcium-activated potassium channel activity(GO:0016286)
0.0	0.0	GO:0034187	obsolete apolipoprotein E binding(GO:0034187)
0.0	0.4	GO:0050681	androgen receptor binding(GO:0050681)
0.0	0.1	GO:0030544	Hsp70 protein binding(GO:0030544)
0.0	0.0	GO:0003918	DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.0	0.1	GO:0032452	histone demethylase activity(GO:0032452)
0.0	0.0	GO:0000339	RNA cap binding(GO:0000339)
0.0	0.0	GO:0016004	phospholipase activator activity(GO:0016004)
0.0	0.1	GO:0043425	bHLH transcription factor binding(GO:0043425)
0.0	0.0	GO:0032552	deoxyribonucleotide binding(GO:0032552)
0.0	0.1	GO:0004594	pantothenate kinase activity(GO:0004594)
0.0	0.1	GO:0004428	obsolete inositol or phosphatidylinositol kinase activity(GO:0004428)
0.0	0.4	GO:0001104	RNA polymerase II transcription cofactor activity(GO:0001104)
0.0	0.1	GO:0030955	potassium ion binding(GO:0030955)
0.0	0.1	GO:0016857	racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.0	0.1	GO:0008467	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0	0.0	GO:0031995	insulin-like growth factor II binding(GO:0031995)
0.0	0.0	GO:0032137	guanine/thymine mispair binding(GO:0032137)
0.0	0.1	GO:0004904	interferon receptor activity(GO:0004904)
0.0	0.1	GO:0015347	sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.0	0.1	GO:0017025	TBP-class protein binding(GO:0017025)
0.0	0.2	GO:0016780	phosphotransferase activity, for other substituted phosphate groups(GO:0016780)
0.0	0.1	GO:0060590	ATPase regulator activity(GO:0060590)
0.0	0.4	GO:0016831	carboxy-lyase activity(GO:0016831)
0.0	0.1	GO:0000014	single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.0	0.1	GO:0019864	IgG binding(GO:0019864)
0.0	0.2	GO:0050699	WW domain binding(GO:0050699)
0.0	0.1	GO:0000062	fatty-acyl-CoA binding(GO:0000062)
0.0	0.0	GO:0030899	calcium-dependent ATPase activity(GO:0030899)
0.0	0.1	GO:0004950	G-protein coupled chemoattractant receptor activity(GO:0001637) chemokine receptor activity(GO:0004950)
0.0	0.1	GO:0005112	Notch binding(GO:0005112)
0.0	0.0	GO:0070577	lysine-acetylated histone binding(GO:0070577)
0.0	0.4	GO:0036459	thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.0	0.2	GO:0003995	acyl-CoA dehydrogenase activity(GO:0003995)
0.0	0.0	GO:0005499	vitamin D binding(GO:0005499)
0.0	0.0	GO:0015194	L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.0	0.1	GO:0034713	type I transforming growth factor beta receptor binding(GO:0034713)
0.0	0.1	GO:0030276	clathrin binding(GO:0030276)
0.0	0.1	GO:0070513	death domain binding(GO:0070513)
0.0	0.0	GO:0005250	A-type (transient outward) potassium channel activity(GO:0005250)
0.0	0.3	GO:0004177	aminopeptidase activity(GO:0004177)
0.0	0.0	GO:0004966	galanin receptor activity(GO:0004966)
0.0	0.3	GO:0003725	double-stranded RNA binding(GO:0003725)
0.0	0.0	GO:0004999	vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.0	0.2	GO:0005487	nucleocytoplasmic transporter activity(GO:0005487)
0.0	0.2	GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0	0.3	GO:0004435	phosphatidylinositol phospholipase C activity(GO:0004435)
0.0	0.0	GO:0030976	thiamine pyrophosphate binding(GO:0030976)
0.0	0.2	GO:0009982	pseudouridine synthase activity(GO:0009982)
0.0	0.0	GO:0031708	bombesin receptor binding(GO:0031705) endothelin B receptor binding(GO:0031708)
0.0	0.1	GO:0004955	prostaglandin receptor activity(GO:0004955)
0.0	0.1	GO:0043325	phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0	0.0	GO:0004911	interleukin-2 receptor activity(GO:0004911)
0.0	0.1	GO:0008046	axon guidance receptor activity(GO:0008046)
0.0	0.0	GO:0050220	prostaglandin-E synthase activity(GO:0050220)
0.0	0.8	GO:0003704	obsolete specific RNA polymerase II transcription factor activity(GO:0003704)
0.0	0.0	GO:0030284	estrogen receptor activity(GO:0030284)
0.0	0.0	GO:0019531	oxalate transmembrane transporter activity(GO:0019531)
0.0	0.0	GO:0036002	pre-mRNA binding(GO:0036002)
0.0	0.4	GO:0004221	obsolete ubiquitin thiolesterase activity(GO:0004221)
0.0	0.1	GO:0031694	alpha-2A adrenergic receptor binding(GO:0031694)
0.0	0.0	GO:0004516	nicotinate phosphoribosyltransferase activity(GO:0004516)
0.0	0.2	GO:0005164	tumor necrosis factor receptor binding(GO:0005164)
0.0	0.0	GO:0004865	protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.0	0.1	GO:0070087	chromo shadow domain binding(GO:0070087)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.8	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.0	0.7	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0	0.4	PID ALK2 PATHWAY	ALK2 signaling events
0.0	1.5	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
0.0	0.9	PID IL8 CXCR2 PATHWAY	IL8- and CXCR2-mediated signaling events
0.0	0.3	PID GMCSF PATHWAY	GMCSF-mediated signaling events
0.0	0.6	SIG BCR SIGNALING PATHWAY	Members of the BCR signaling pathway
0.0	0.4	SIG IL4RECEPTOR IN B LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes
0.0	0.2	PID PI3KCI PATHWAY	Class I PI3K signaling events
0.0	0.1	PID ERB GENOMIC PATHWAY	Validated nuclear estrogen receptor beta network
0.0	0.4	PID WNT CANONICAL PATHWAY	Canonical Wnt signaling pathway
0.0	0.9	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0	0.4	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
0.0	0.3	ST PHOSPHOINOSITIDE 3 KINASE PATHWAY	PI3K Pathway
0.0	0.1	PID HDAC CLASSII PATHWAY	Signaling events mediated by HDAC Class II
0.0	0.1	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.0	0.4	PID IL2 1PATHWAY	IL2-mediated signaling events
0.0	0.1	SA G1 AND S PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.0	0.2	PID ARF6 DOWNSTREAM PATHWAY	Arf6 downstream pathway
0.0	0.2	PID IL2 PI3K PATHWAY	IL2 signaling events mediated by PI3K
0.0	0.2	PID RANBP2 PATHWAY	Sumoylation by RanBP2 regulates transcriptional repression
0.0	0.3	PID HIF1A PATHWAY	Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0	0.1	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0	0.0	ST GRANULE CELL SURVIVAL PATHWAY	Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.0	0.0	PID TRAIL PATHWAY	TRAIL signaling pathway
0.0	0.1	PID MET PATHWAY	Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.0	0.3	PID NFAT 3PATHWAY	Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.0	0.3	PID HIF2PATHWAY	HIF-2-alpha transcription factor network
0.0	0.5	PID IL4 2PATHWAY	IL4-mediated signaling events
0.0	0.0	ST DIFFERENTIATION PATHWAY IN PC12 CELLS	Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.0	0.3	PID IFNG PATHWAY	IFN-gamma pathway
0.0	0.2	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0	0.2	SA CASPASE CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0	0.0	PID AR NONGENOMIC PATHWAY	Nongenotropic Androgen signaling
0.0	0.0	PID FAS PATHWAY	FAS (CD95) signaling pathway
0.0	0.3	PID LIS1 PATHWAY	Lissencephaly gene (LIS1) in neuronal migration and development
0.0	0.3	PID ATM PATHWAY	ATM pathway
0.0	0.0	PID LYMPH ANGIOGENESIS PATHWAY	VEGFR3 signaling in lymphatic endothelium
0.0	0.5	PID NOTCH PATHWAY	Notch signaling pathway
0.0	0.6	PID ERA GENOMIC PATHWAY	Validated nuclear estrogen receptor alpha network
0.0	0.0	PID CD8 TCR PATHWAY	TCR signaling in naïve CD8+ T cells
0.0	0.1	PID EPHB FWD PATHWAY	EPHB forward signaling
0.0	0.2	PID CD8 TCR DOWNSTREAM PATHWAY	Downstream signaling in naïve CD8+ T cells
0.0	0.1	PID DNA PK PATHWAY	DNA-PK pathway in nonhomologous end joining
0.0	0.1	PID LPA4 PATHWAY	LPA4-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.1	REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE	Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.1	0.2	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.1	0.2	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.1	0.1	REACTOME SIGNALING BY ERBB2	Genes involved in Signaling by ERBB2
0.0	1.1	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
0.0	0.1	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.0	0.6	REACTOME PLATELET SENSITIZATION BY LDL	Genes involved in Platelet sensitization by LDL
0.0	0.4	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.0	0.2	REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	Genes involved in DCC mediated attractive signaling
0.0	0.1	REACTOME G PROTEIN BETA GAMMA SIGNALLING	Genes involved in G-protein beta:gamma signalling
0.0	0.1	REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1	Genes involved in Autodegradation of the E3 ubiquitin ligase COP1
0.0	0.3	REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND	Genes involved in Removal of the Flap Intermediate from the C-strand
0.0	0.2	REACTOME REGULATION OF SIGNALING BY CBL	Genes involved in Regulation of signaling by CBL
0.0	0.5	REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS	Genes involved in Nucleotide-like (purinergic) receptors
0.0	0.1	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
0.0	0.3	REACTOME ALPHA LINOLENIC ACID ALA METABOLISM	Genes involved in alpha-linolenic acid (ALA) metabolism
0.0	0.0	REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0	0.1	REACTOME COSTIMULATION BY THE CD28 FAMILY	Genes involved in Costimulation by the CD28 family
0.0	0.1	REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION	Genes involved in Influenza Viral RNA Transcription and Replication
0.0	0.7	REACTOME ELONGATION ARREST AND RECOVERY	Genes involved in Elongation arrest and recovery
0.0	0.3	REACTOME P38MAPK EVENTS	Genes involved in p38MAPK events
0.0	0.3	REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS	Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0	0.1	REACTOME G ALPHA Z SIGNALLING EVENTS	Genes involved in G alpha (z) signalling events
0.0	0.2	REACTOME SOS MEDIATED SIGNALLING	Genes involved in SOS-mediated signalling
0.0	0.1	REACTOME CTLA4 INHIBITORY SIGNALING	Genes involved in CTLA4 inhibitory signaling
0.0	0.0	REACTOME SPRY REGULATION OF FGF SIGNALING	Genes involved in Spry regulation of FGF signaling
0.0	0.6	REACTOME RECYCLING PATHWAY OF L1	Genes involved in Recycling pathway of L1
0.0	0.4	REACTOME PLATELET CALCIUM HOMEOSTASIS	Genes involved in Platelet calcium homeostasis
0.0	0.2	REACTOME REGULATORY RNA PATHWAYS	Genes involved in Regulatory RNA pathways
0.0	0.3	REACTOME EGFR DOWNREGULATION	Genes involved in EGFR downregulation
0.0	0.0	REACTOME INFLUENZA LIFE CYCLE	Genes involved in Influenza Life Cycle
0.0	0.0	REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY	Genes involved in Adenylate cyclase activating pathway
0.0	1.2	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.0	1.1	REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES	Genes involved in Antiviral mechanism by IFN-stimulated genes
0.0	0.3	REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0	0.4	REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0	0.1	REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS	Genes involved in Membrane binding and targetting of GAG proteins
0.0	0.0	REACTOME ABORTIVE ELONGATION OF HIV1 TRANSCRIPT IN THE ABSENCE OF TAT	Genes involved in Abortive elongation of HIV-1 transcript in the absence of Tat
0.0	0.5	REACTOME GPVI MEDIATED ACTIVATION CASCADE	Genes involved in GPVI-mediated activation cascade
0.0	0.0	REACTOME TRAF6 MEDIATED NFKB ACTIVATION	Genes involved in TRAF6 mediated NF-kB activation
0.0	0.1	REACTOME INTEGRATION OF PROVIRUS	Genes involved in Integration of provirus
0.0	0.1	REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER	Genes involved in RNA Polymerase III Transcription Initiation From Type 2 Promoter
0.0	0.3	REACTOME FORMATION OF TRANSCRIPTION COUPLED NER TC NER REPAIR COMPLEX	Genes involved in Formation of transcription-coupled NER (TC-NER) repair complex
0.0	0.3	REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING	Genes involved in Downregulation of TGF-beta receptor signaling
0.0	0.2	REACTOME HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS	Genes involved in Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
0.0	0.2	REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS	Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0	0.0	REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY	Genes involved in TRAF3-dependent IRF activation pathway
0.0	0.4	REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS	Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0	0.1	REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES	Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0	0.0	REACTOME CA DEPENDENT EVENTS	Genes involved in Ca-dependent events
0.0	0.1	REACTOME ACTIVATION OF NF KAPPAB IN B CELLS	Genes involved in Activation of NF-kappaB in B Cells
0.0	0.1	REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION	Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0	0.0	REACTOME RETROGRADE NEUROTROPHIN SIGNALLING	Genes involved in Retrograde neurotrophin signalling
0.0	0.1	REACTOME HOST INTERACTIONS OF HIV FACTORS	Genes involved in Host Interactions of HIV factors
0.0	0.2	REACTOME PYRIMIDINE CATABOLISM	Genes involved in Pyrimidine catabolism
0.0	0.2	REACTOME DEADENYLATION OF MRNA	Genes involved in Deadenylation of mRNA
0.0	0.2	REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR	Genes involved in Trafficking and processing of endosomal TLR
0.0	0.2	REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX	Genes involved in Association of licensing factors with the pre-replicative complex
0.0	0.2	REACTOME TCR SIGNALING	Genes involved in TCR signaling
0.0	0.1	REACTOME RNA POL I TRANSCRIPTION TERMINATION	Genes involved in RNA Polymerase I Transcription Termination
0.0	0.3	REACTOME KINESINS	Genes involved in Kinesins
0.0	0.2	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.0	0.2	REACTOME SIGNALING BY FGFR1 FUSION MUTANTS	Genes involved in Signaling by FGFR1 fusion mutants
0.0	0.1	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.0	0.2	REACTOME NOD1 2 SIGNALING PATHWAY	Genes involved in NOD1/2 Signaling Pathway
0.0	0.2	REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS	Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.0	0.3	REACTOME CITRIC ACID CYCLE TCA CYCLE	Genes involved in Citric acid cycle (TCA cycle)
0.0	0.1	REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS	Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0	0.2	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade
0.0	0.2	REACTOME G1 PHASE	Genes involved in G1 Phase
0.0	0.1	REACTOME GAP JUNCTION DEGRADATION	Genes involved in Gap junction degradation
0.0	0.0	REACTOME GLUCOSE METABOLISM	Genes involved in Glucose metabolism
0.0	0.3	REACTOME MRNA SPLICING MINOR PATHWAY	Genes involved in mRNA Splicing - Minor Pathway
0.0	0.1	REACTOME UNWINDING OF DNA	Genes involved in Unwinding of DNA
0.0	0.2	REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION	Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0	0.1	REACTOME PROSTANOID LIGAND RECEPTORS	Genes involved in Prostanoid ligand receptors
0.0	0.2	REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION	Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0	0.0	REACTOME SEMA3A PAK DEPENDENT AXON REPULSION	Genes involved in Sema3A PAK dependent Axon repulsion
0.0	0.2	REACTOME CHONDROITIN SULFATE BIOSYNTHESIS	Genes involved in Chondroitin sulfate biosynthesis
0.0	0.5	REACTOME VOLTAGE GATED POTASSIUM CHANNELS	Genes involved in Voltage gated Potassium channels
0.0	0.0	REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6	Genes involved in CDK-mediated phosphorylation and removal of Cdc6
0.0	0.1	REACTOME DSCAM INTERACTIONS	Genes involved in DSCAM interactions
0.0	0.2	REACTOME APC C CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS	Genes involved in APC/C:Cdc20 mediated degradation of mitotic proteins
0.0	0.5	REACTOME CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE	Genes involved in Cell death signalling via NRAGE, NRIF and NADE
0.0	0.1	REACTOME CTNNB1 PHOSPHORYLATION CASCADE	Genes involved in Beta-catenin phosphorylation cascade
0.0	0.0	REACTOME ARMS MEDIATED ACTIVATION	Genes involved in ARMS-mediated activation
0.0	0.0	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING	Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.0	0.1	REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS	Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0	0.0	REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR	Genes involved in Signaling by constitutively active EGFR
0.0	0.1	REACTOME ACTIVATION OF BH3 ONLY PROTEINS	Genes involved in Activation of BH3-only proteins
0.0	0.0	REACTOME SHC1 EVENTS IN EGFR SIGNALING	Genes involved in SHC1 events in EGFR signaling
0.0	0.2	REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE	Genes involved in Synthesis of PIPs at the plasma membrane
0.0	0.1	REACTOME METABOLISM OF NON CODING RNA	Genes involved in Metabolism of non-coding RNA
0.0	0.1	REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA	Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0	0.1	REACTOME THE NLRP3 INFLAMMASOME	Genes involved in The NLRP3 inflammasome

Results for RFX7_RFX4_RFX1

Z-value: 1.80

Motif logo

Transcription factors associated with RFX7_RFX4_RFX1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Activity of the RFX7_RFX4_RFX1 motif across conditions

Conditions sorted by the z-value of the RFX7_RFX4_RFX1 motif activity

Top target CREs of the motif:

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of RFX7_RFX4_RFX1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: