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ENCODE: H3K4me1 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for RORA

Z-value: 1.64

Motif logo

Transcription factors associated with RORA

Gene Symbol	Gene ID	Gene Info
RORA Ensembl NCBI GeneCards UniProt	ENSG00000069667.11	RORA

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
RORA	chr15_60883775_60883968	869	0.664381	-0.89	1.5e-03	Click!
RORA	chr15_60885332_60885500	91	0.977330	-0.79	1.0e-02	Click!
RORA	chr15_60936882_60937033	17295	0.206626	0.74	2.3e-02	Click!
RORA	chr15_60884114_60884267	550	0.812497	-0.73	2.4e-02	Click!
RORA	chr15_60902634_60902785	16934	0.216934	-0.70	3.5e-02	Click!

Activity of the RORA motif across conditions

Conditions sorted by the z-value of the RORA motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr12_50611338_50611602	0.62	RP3-405J10.4		1917	0.22
chr9_18437920_18438071	0.57	ADAMTSL1	ADAMTS-like 1	35897	0.23
chr17_39217082_39217233	0.56	KRTAP2-3	keratin associated protein 2-3	813	0.31
chr9_89990192_89990343	0.56	ENSG00000212421	.	114902	0.06
chr17_73872544_73873300	0.54	TRIM47	tripartite motif containing 47	423	0.43
chr18_24196978_24197129	0.54	KCTD1	potassium channel tetramerization domain containing 1	12153	0.2
chr9_83646594_83646895	0.54	ENSG00000221581	.	297500	0.01
chr3_149738658_149738809	0.54	PFN2	profilin 2	1865	0.34
chr6_140382856_140383007	0.53	ENSG00000252107	.	96900	0.09
chr5_150025102_150025253	0.53	SYNPO	synaptopodin	4937	0.16
chr2_9571047_9571198	0.53	CPSF3	cleavage and polyadenylation specific factor 3, 73kDa	7109	0.19
chr10_115234705_115234856	0.52	HABP2	hyaluronan binding protein 2	75816	0.11
chr5_53683581_53683732	0.52	HSPB3	heat shock 27kDa protein 3	67789	0.12
chr1_68403039_68403338	0.52	GNG12-AS1	GNG12 antisense RNA 1	17900	0.24
chr6_57129918_57130069	0.51	RAB23	RAB23, member RAS oncogene family	42915	0.15
chr2_9777860_9778099	0.51	YWHAQ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta	6836	0.21
chr14_86031688_86031839	0.51	FLRT2	fibronectin leucine rich transmembrane protein 2	35191	0.2
chr6_37423751_37423902	0.50	CMTR1	cap methyltransferase 1	19269	0.19
chr1_20390393_20390544	0.50	PLA2G5	phospholipase A2, group V	6233	0.2
chr2_19323725_19323876	0.49	ENSG00000266738	.	224390	0.02
chr1_64991178_64991359	0.49	ENSG00000264470	.	54262	0.14
chr2_33294539_33294812	0.49	LTBP1	latent transforming growth factor beta binding protein 1	64798	0.12
chr4_96028162_96028313	0.48	BMPR1B	bone morphogenetic protein receptor, type IB	2731	0.44
chr5_33612837_33612988	0.48	TARS	threonyl-tRNA synthetase	171425	0.03
chr8_117600503_117600654	0.48	EIF3H	eukaryotic translation initiation factor 3, subunit H	167445	0.03
chr16_66416650_66416801	0.47	CDH5	cadherin 5, type 2 (vascular endothelium)	3597	0.24
chr11_9191471_9191622	0.47	DENND5A	DENN/MADD domain containing 5A	2246	0.32
chr16_65151739_65151890	0.47	CDH11	cadherin 11, type 2, OB-cadherin (osteoblast)	4019	0.39
chr5_145356260_145356548	0.46	SH3RF2	SH3 domain containing ring finger 2	38964	0.18
chr3_187952552_187952703	0.46	LPP	LIM domain containing preferred translocation partner in lipoma	5025	0.29
chr18_8213240_8213391	0.46	ENSG00000212067	.	13868	0.23
chr12_69927570_69927949	0.46	FRS2	fibroblast growth factor receptor substrate 2	3156	0.27
chr3_66033537_66033688	0.45	MAGI1	membrane associated guanylate kinase, WW and PDZ domain containing 1	9387	0.23
chr9_6567455_6567606	0.45	ENSG00000252110	.	1105	0.53
chr20_10829555_10829706	0.45	RP11-103J8.1		53302	0.17
chr19_17422479_17422790	0.45	ABHD8	abhydrolase domain containing 8	1589	0.16
chr8_119065102_119065253	0.44	EXT1	exostosin glycosyltransferase 1	57476	0.17
chr3_50285847_50286499	0.43	GNAI2	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	1847	0.19
chr19_2149731_2150754	0.43	AP3D1	adaptor-related protein complex 3, delta 1 subunit	1297	0.32
chr11_12821990_12822259	0.43	RP11-47J17.3		23090	0.19
chr10_79743394_79743545	0.43	POLR3A	polymerase (RNA) III (DNA directed) polypeptide A, 155kDa	45834	0.12
chr3_138188194_138188345	0.43	CEP70	centrosomal protein 70kDa	30753	0.18
chr13_76345505_76345656	0.43	LMO7	LIM domain 7	10783	0.26
chr3_114161428_114161579	0.42	ZBTB20	zinc finger and BTB domain containing 20	12027	0.25
chr1_203503489_203503640	0.42	OPTC	opticin	38466	0.16
chr6_41065063_41065214	0.42	OARD1	O-acyl-ADP-ribose deacylase 1	359	0.81
chr20_60735818_60735969	0.42	SS18L1	synovial sarcoma translocation gene on chromosome 18-like 1	2049	0.25
chr1_118229559_118229710	0.42	ENSG00000212266	.	1730	0.47
chr3_106927449_106927600	0.42	ENSG00000220989	.	156505	0.04
chr1_85805849_85806000	0.42	ENSG00000264380	.	55631	0.09
chr15_85888485_85888636	0.42	AKAP13	A kinase (PRKA) anchor protein 13	35258	0.15
chr8_123868137_123868288	0.42	ZHX2	zinc fingers and homeoboxes 2	7412	0.2
chr16_69074448_69074599	0.41	ENSG00000202497	.	33465	0.14
chr5_138397564_138397715	0.41	SIL1	SIL1 nucleotide exchange factor	19268	0.18
chr15_74232933_74233272	0.41	LOXL1-AS1	LOXL1 antisense RNA 1	12513	0.14
chr12_26148588_26148739	0.41	RASSF8	Ras association (RalGDS/AF-6) domain family (N-terminal) member 8	726	0.74
chr4_160281542_160281693	0.41	RAPGEF2	Rap guanine nucleotide exchange factor (GEF) 2	10237	0.27
chr17_36620738_36620994	0.41	ARHGAP23	Rho GTPase activating protein 23	7222	0.17
chr4_73836894_73837045	0.40	ENSG00000252955	.	6074	0.28
chr13_33700338_33700489	0.40	STARD13-IT1	STARD13 intronic transcript 1 (non-protein coding)	38133	0.17
chr8_8522351_8522502	0.40	ENSG00000264445	.	31452	0.18
chr5_152869678_152869829	0.40	GRIA1	glutamate receptor, ionotropic, AMPA 1	353	0.94
chr7_151200413_151200564	0.40	RHEB	Ras homolog enriched in brain	14667	0.16
chr2_150451982_150452133	0.40	MMADHC	methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria	7727	0.21
chr2_74004592_74004743	0.40	DUSP11	dual specificity phosphatase 11 (RNA/RNP complex 1-interacting)	2428	0.25
chr17_65214980_65215131	0.40	RP11-401F2.4		5364	0.17
chr12_4140465_4141124	0.39	RP11-664D1.1		126408	0.05
chr6_143591799_143591950	0.39	AIG1	androgen-induced 1	144487	0.04
chr8_124656767_124656918	0.39	KLHL38	kelch-like family member 38	8348	0.2
chr16_4263907_4264209	0.39	SRL	sarcalumenin	25686	0.16
chr1_178209193_178209344	0.39	RASAL2	RAS protein activator like 2	101338	0.08
chr14_96556907_96557058	0.39	C14orf132	chromosome 14 open reading frame 132	386	0.88
chr2_46542032_46542183	0.38	EPAS1	endothelial PAS domain protein 1	17566	0.25
chr4_15454262_15454413	0.38	CC2D2A	coiled-coil and C2 domain containing 2A	17152	0.16
chr5_112417198_112417349	0.38	DCP2	decapping mRNA 2	104794	0.06
chr10_114846149_114846300	0.38	TCF7L2	transcription factor 7-like 2 (T-cell specific, HMG-box)	57455	0.15
chr6_76147282_76147433	0.38	ENSG00000263533	.	9234	0.18
chr11_63440539_63440690	0.38	ATL3	atlastin GTPase 3	1221	0.4
chr16_82787297_82787448	0.38	RP11-22H5.2		19552	0.24
chr14_25580776_25580927	0.38	STXBP6	syntaxin binding protein 6 (amisyn)	61348	0.15
chr11_118491249_118491656	0.38	PHLDB1	pleckstrin homology-like domain, family B, member 1	13094	0.11
chr1_93405805_93405956	0.38	FAM69A	family with sequence similarity 69, member A	21177	0.12
chr1_159567510_159567661	0.38	APCS	amyloid P component, serum	9970	0.22
chr3_192603097_192603248	0.38	MB21D2	Mab-21 domain containing 2	32778	0.23
chr14_100275563_100275795	0.38	EML1	echinoderm microtubule associated protein like 1	109	0.98
chr20_13010496_13010647	0.37	SPTLC3	serine palmitoyltransferase, long chain base subunit 3	20574	0.28
chr3_54897591_54897742	0.37	CACNA2D3-AS1	CACNA2D3 antisense RNA 1	37616	0.21
chr6_140247827_140247978	0.37	ENSG00000252107	.	231929	0.02
chr11_91863154_91863305	0.37	FAT3	FAT atypical cadherin 3	222033	0.02
chr11_100746918_100747069	0.37	ENSG00000200047	.	36632	0.15
chr2_190700976_190701127	0.37	PMS1	PMS1 postmeiotic segregation increased 1 (S. cerevisiae)	18198	0.15
chr15_62737179_62737605	0.37	TLN2	talin 2	116172	0.06
chr13_32368184_32368335	0.37	RXFP2	relaxin/insulin-like family peptide receptor 2	54580	0.17
chr5_102808188_102808485	0.36	NUDT12	nudix (nucleoside diphosphate linked moiety X)-type motif 12	90154	0.1
chr5_101963356_101963507	0.36	RP11-58B2.1		122458	0.06
chr19_48991020_48991171	0.36	CYTH2	cytohesin 2	15486	0.09
chr3_189428781_189428932	0.36	TP63	tumor protein p63	78593	0.11
chr10_60766507_60766658	0.36	ENSG00000252076	.	137638	0.05
chr22_40998121_40998272	0.36	MKL1	megakaryoblastic leukemia (translocation) 1	34493	0.16
chr16_83437863_83438014	0.36	ENSG00000222299	.	3718	0.27
chr7_34082557_34082708	0.36	BMPER	BMP binding endothelial regulator	137487	0.05
chr8_96653162_96653313	0.36	ENSG00000223297	.	37906	0.19
chr1_12483776_12483927	0.35	VPS13D	vacuolar protein sorting 13 homolog D (S. cerevisiae)	13927	0.23
chr2_205370374_205370525	0.35	PARD3B	par-3 family cell polarity regulator beta	40067	0.23
chr21_47480957_47481280	0.35	AP001471.1		36326	0.12
chr10_71567463_71567614	0.35	ENSG00000222631	.	4913	0.22
chr8_69766358_69766509	0.35	ENSG00000239184	.	158555	0.04
chr4_54643319_54643470	0.35	LNX1	ligand of numb-protein X 1, E3 ubiquitin protein ligase	75822	0.1
chr18_43209000_43209203	0.35	SLC14A2	solute carrier family 14 (urea transporter), member 2	14335	0.2
chr9_111799017_111799168	0.35	ENSG00000199331	.	5675	0.16
chr3_55208193_55208344	0.35	LRTM1	leucine-rich repeats and transmembrane domains 1	207153	0.03
chr2_153370502_153370653	0.35	FMNL2	formin-like 2	105515	0.08
chr6_35364753_35364904	0.35	PPARD	peroxisome proliferator-activated receptor delta	54426	0.1
chr10_114807131_114807282	0.35	RP11-57H14.2		95572	0.08
chr9_72664551_72664702	0.35	MAMDC2	MAM domain containing 2	6129	0.26
chr14_93701710_93701861	0.35	UBR7	ubiquitin protein ligase E3 component n-recognin 7 (putative)	16758	0.14
chr11_116705965_116706733	0.35	APOA1-AS	APOA1 antisense RNA	484	0.63
chr10_128087058_128087209	0.35	ADAM12	ADAM metallopeptidase domain 12	10109	0.27
chr11_102048059_102048210	0.35	YAP1	Yes-associated protein 1	8678	0.21
chr3_189491567_189491718	0.35	TP63	tumor protein p63	15807	0.26
chr10_98574486_98574637	0.34	ENSG00000207976	.	13960	0.18
chr14_89302209_89302360	0.34	ENSG00000207342	.	4225	0.2
chr1_201679077_201679228	0.34	ENSG00000264802	.	9484	0.13
chr2_43152776_43153425	0.34	HAAO	3-hydroxyanthranilate 3,4-dioxygenase	133368	0.05
chr7_47803470_47803621	0.34	LINC00525	long intergenic non-protein coding RNA 525	598	0.78
chr18_8231250_8231401	0.34	ENSG00000212067	.	4142	0.29
chr10_79291019_79291170	0.34	ENSG00000199592	.	55713	0.15
chr9_13939488_13939639	0.34	NFIB	nuclear factor I/B	241228	0.02
chr8_29368707_29368858	0.34	RP4-676L2.1		158095	0.04
chr15_48751523_48751674	0.34	DUT	deoxyuridine triphosphatase	126995	0.05
chrX_11456077_11456228	0.34	ARHGAP6	Rho GTPase activating protein 6	10259	0.3
chr8_118990982_118991133	0.34	EXT1	exostosin glycosyltransferase 1	131596	0.06
chr9_100528747_100528898	0.34	ENSG00000266608	.	66306	0.09
chr5_34598742_34598893	0.34	RAI14	retinoic acid induced 14	57525	0.14
chr14_56381140_56381291	0.34	ENSG00000212522	.	153946	0.04
chr20_36688656_36688807	0.34	ENSG00000252791	.	7583	0.16
chr11_128077291_128077590	0.33	ETS1	v-ets avian erythroblastosis virus E26 oncogene homolog 1	297849	0.01
chr5_64337655_64337871	0.33	ENSG00000207439	.	81433	0.11
chr7_32201662_32201813	0.33	PDE1C	phosphodiesterase 1C, calmodulin-dependent 70kDa	90689	0.1
chr8_8153749_8153900	0.33	ALG1L13P	asparagine-linked glycosylation 1-like 13, pseudogene	54891	0.11
chr7_127410750_127410901	0.33	SND1	staphylococcal nuclease and tudor domain containing 1	117140	0.05
chr13_60713678_60713829	0.33	DIAPH3-AS2	DIAPH3 antisense RNA 2	5079	0.24
chr13_49672995_49673224	0.33	ENSG00000199788	.	3582	0.27
chr1_201423553_201423704	0.33	PHLDA3	pleckstrin homology-like domain, family A, member 3	14684	0.15
chr2_20793453_20793604	0.33	HS1BP3-IT1	HS1BP3 intronic transcript 1 (non-protein coding)	1220	0.52
chr7_143190324_143190475	0.33	TAS2R41	taste receptor, type 2, member 41	15433	0.16
chr11_33713061_33713264	0.33	RP4-541C22.5		5085	0.19
chr8_89130096_89130247	0.33	CTB-118P15.2		143778	0.05
chr10_33631255_33631406	0.33	NRP1	neuropilin 1	6140	0.29
chr10_35620918_35621160	0.33	RP11-324I22.4		4290	0.22
chr4_95330317_95330468	0.33	PDLIM5	PDZ and LIM domain 5	42645	0.19
chr2_175659979_175660130	0.33	CHRNA1	cholinergic receptor, nicotinic, alpha 1 (muscle)	30854	0.19
chr4_157897574_157897725	0.33	PDGFC	platelet derived growth factor C	5103	0.24
chr13_42423265_42423416	0.33	ENSG00000241406	.	41527	0.17
chr16_65347210_65347398	0.33	CDH11	cadherin 11, type 2, OB-cadherin (osteoblast)	191036	0.03
chrY_28466108_28466259	0.32	ENSG00000252948	.	40953	0.2
chr5_10453332_10453562	0.32	ROPN1L	rhophilin associated tail protein 1-like	11459	0.14
chr16_73102131_73102454	0.32	ZFHX3	zinc finger homeobox 3	8695	0.24
chr19_3374038_3374830	0.32	NFIC	nuclear factor I/C (CCAAT-binding transcription factor)	7850	0.19
chr18_25763676_25763827	0.32	CDH2	cadherin 2, type 1, N-cadherin (neuronal)	6341	0.35
chr6_11188200_11188351	0.32	RP3-510L9.1		14590	0.2
chr16_53728728_53728879	0.32	RPGRIP1L	RPGRIP1-like	8919	0.23
chr5_14191108_14191422	0.32	TRIO	trio Rho guanine nucleotide exchange factor	7358	0.33
chr3_159444348_159444499	0.32	IQCJ-SCHIP1	IQCJ-SCHIP1 readthrough	37079	0.16
chr9_89021972_89022123	0.32	ENSG00000222293	.	15996	0.24
chr20_43683503_43683886	0.32	KCNS1	potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1	46056	0.1
chr16_49677699_49678055	0.32	ZNF423	zinc finger protein 423	3114	0.33
chr3_123588793_123588944	0.32	MYLK	myosin light chain kinase	14281	0.22
chr2_236342022_236342173	0.32	AGAP1	ArfGAP with GTPase domain, ankyrin repeat and PH domain 1	60636	0.13
chr2_74373621_74374624	0.32	BOLA3	bolA family member 3	910	0.35
chr11_12191424_12191575	0.32	MICAL2	microtubule associated monooxygenase, calponin and LIM domain containing 2	7796	0.27
chr7_41950835_41950986	0.32	AC005027.3		205977	0.03
chr6_160457258_160457573	0.32	AIRN	antisense of IGF2R non-protein coding RNA	28719	0.19
chr1_52434488_52434639	0.32	ENSG00000200839	.	4519	0.15
chr7_94050761_94050912	0.32	COL1A2	collagen, type I, alpha 2	26963	0.22
chr5_88027740_88027966	0.32	CTC-467M3.2		39385	0.16
chr1_18201641_18201961	0.32	ACTL8	actin-like 8	119993	0.06
chr10_33274428_33274757	0.31	ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	6799	0.27
chr3_78968042_78968193	0.31	ENSG00000240964	.	19325	0.28
chr19_1168901_1169806	0.31	SBNO2	strawberry notch homolog 2 (Drosophila)	411	0.76
chr21_30143536_30143687	0.31	ENSG00000251894	.	28081	0.23
chr4_150085945_150086096	0.31	ENSG00000239168	.	173235	0.04
chr8_32201421_32201572	0.31	ENSG00000200246	.	87484	0.09
chr12_47629984_47630533	0.31	PCED1B	PC-esterase domain containing 1B	12930	0.21
chr2_110756993_110757205	0.31	ENSG00000265682	.	70520	0.1
chr3_187453619_187453770	0.31	BCL6	B-cell CLL/lymphoma 6	663	0.73
chr2_113075036_113075187	0.31	ZC3H6	zinc finger CCCH-type containing 6	41933	0.14
chr16_72289972_72290233	0.31	PMFBP1	polyamine modulated factor 1 binding protein 1	79325	0.09
chr1_225836875_225837026	0.31	ENAH	enabled homolog (Drosophila)	3468	0.27
chr1_46379565_46379716	0.31	MAST2	microtubule associated serine/threonine kinase 2	380	0.91
chr4_174267247_174267398	0.31	HMGB2	high mobility group box 2	11046	0.13
chrY_27544696_27544847	0.31	ENSG00000272042	.	60283	0.14
chr5_95571294_95571445	0.31	ENSG00000206997	.	25438	0.24
chr11_34324437_34324812	0.31	ABTB2	ankyrin repeat and BTB (POZ) domain containing 2	54178	0.15
chr7_90012529_90012680	0.31	CLDN12	claudin 12	431	0.85
chr6_74783073_74783224	0.31	RP11-553A21.3		377294	0.01
chr12_2723257_2723602	0.31	CACNA1C-AS3	CACNA1C antisense RNA 3	6823	0.24
chr15_99440684_99440835	0.31	RP11-654A16.1		3995	0.25
chr16_87120081_87120232	0.31	RP11-899L11.3		129365	0.05
chr13_102263996_102264147	0.31	ITGBL1	integrin, beta-like 1 (with EGF-like repeat domains)	13576	0.3

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of RORA

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.5	GO:0060666	dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.1	0.5	GO:0043589	skin morphogenesis(GO:0043589)
0.1	0.3	GO:0048143	astrocyte activation(GO:0048143)
0.1	0.2	GO:0022605	oogenesis stage(GO:0022605)
0.1	0.2	GO:0006562	proline catabolic process(GO:0006562)
0.1	0.2	GO:0051497	negative regulation of stress fiber assembly(GO:0051497)
0.1	0.2	GO:0001778	plasma membrane repair(GO:0001778)
0.1	0.2	GO:0060754	mast cell chemotaxis(GO:0002551) regulation of mast cell chemotaxis(GO:0060753) positive regulation of mast cell chemotaxis(GO:0060754) mast cell migration(GO:0097531)
0.1	0.1	GO:0001543	ovarian follicle rupture(GO:0001543)
0.1	0.3	GO:0097061	dendritic spine morphogenesis(GO:0060997) regulation of dendritic spine morphogenesis(GO:0061001) dendritic spine organization(GO:0097061)
0.1	0.2	GO:0015014	heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.1	0.2	GO:0006663	platelet activating factor biosynthetic process(GO:0006663)
0.1	0.2	GO:0060242	contact inhibition(GO:0060242)
0.1	0.2	GO:0001743	optic placode formation(GO:0001743)
0.0	0.2	GO:0060013	righting reflex(GO:0060013)
0.0	0.2	GO:0006020	inositol metabolic process(GO:0006020)
0.0	0.1	GO:0045162	clustering of voltage-gated sodium channels(GO:0045162)
0.0	0.1	GO:0010766	negative regulation of sodium ion transport(GO:0010766)
0.0	0.2	GO:0051124	synaptic growth at neuromuscular junction(GO:0051124)
0.0	0.2	GO:0070141	response to UV-A(GO:0070141)
0.0	0.1	GO:0048003	antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003)
0.0	0.2	GO:0048149	behavioral response to ethanol(GO:0048149)
0.0	0.1	GO:2000114	regulation of establishment of cell polarity(GO:2000114)
0.0	0.1	GO:0019800	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0	0.3	GO:0010896	regulation of triglyceride catabolic process(GO:0010896)
0.0	0.2	GO:0048625	myoblast fate commitment(GO:0048625)
0.0	0.2	GO:0009169	purine nucleoside monophosphate catabolic process(GO:0009128) ribonucleoside monophosphate catabolic process(GO:0009158) purine ribonucleoside monophosphate catabolic process(GO:0009169)
0.0	0.0	GO:0043117	positive regulation of vascular permeability(GO:0043117)
0.0	0.2	GO:0008218	bioluminescence(GO:0008218)
0.0	0.1	GO:0001973	adenosine receptor signaling pathway(GO:0001973) G-protein coupled purinergic receptor signaling pathway(GO:0035588)
0.0	0.1	GO:0071436	sodium ion export(GO:0071436)
0.0	0.1	GO:0060665	regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.0	0.1	GO:0044413	evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.0	0.1	GO:0009414	response to water deprivation(GO:0009414)
0.0	0.2	GO:0045898	regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0	0.1	GO:0035385	Roundabout signaling pathway(GO:0035385)
0.0	0.1	GO:0002689	negative regulation of leukocyte chemotaxis(GO:0002689)
0.0	0.2	GO:0001514	selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.0	0.1	GO:0031340	positive regulation of vesicle fusion(GO:0031340)
0.0	0.3	GO:0048207	vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208) COPII-coated vesicle budding(GO:0090114)
0.0	0.1	GO:0051182	coenzyme transport(GO:0051182)
0.0	0.2	GO:0002281	macrophage activation involved in immune response(GO:0002281)
0.0	0.1	GO:0046113	nucleobase catabolic process(GO:0046113)
0.0	0.1	GO:0046952	ketone body catabolic process(GO:0046952)
0.0	0.1	GO:0035511	oxidative DNA demethylation(GO:0035511)
0.0	0.1	GO:0010193	response to ozone(GO:0010193)
0.0	0.1	GO:0050774	negative regulation of dendrite morphogenesis(GO:0050774)
0.0	0.1	GO:0051088	PMA-inducible membrane protein ectodomain proteolysis(GO:0051088)
0.0	0.0	GO:0098870	neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0	0.1	GO:0006102	isocitrate metabolic process(GO:0006102)
0.0	0.1	GO:0031065	positive regulation of histone deacetylation(GO:0031065)
0.0	0.1	GO:0055098	response to low-density lipoprotein particle(GO:0055098)
0.0	0.3	GO:0033631	cell-cell adhesion mediated by integrin(GO:0033631)
0.0	0.2	GO:0045075	interleukin-12 biosynthetic process(GO:0042090) regulation of interleukin-12 biosynthetic process(GO:0045075)
0.0	0.1	GO:0014874	response to stimulus involved in regulation of muscle adaptation(GO:0014874)
0.0	0.2	GO:0045662	negative regulation of myoblast differentiation(GO:0045662)
0.0	0.1	GO:0060676	ureteric bud formation(GO:0060676)
0.0	0.1	GO:0071694	sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.0	0.1	GO:0046121	deoxyribonucleoside catabolic process(GO:0046121)
0.0	0.1	GO:0018242	protein O-linked glycosylation via serine(GO:0018242) protein O-linked glycosylation via threonine(GO:0018243)
0.0	0.0	GO:0010715	regulation of extracellular matrix disassembly(GO:0010715) negative regulation of extracellular matrix disassembly(GO:0010716) regulation of extracellular matrix organization(GO:1903053) negative regulation of extracellular matrix organization(GO:1903054)
0.0	0.1	GO:0060083	smooth muscle contraction involved in micturition(GO:0060083)
0.0	0.2	GO:0042640	anagen(GO:0042640)
0.0	0.1	GO:0032988	ribonucleoprotein complex disassembly(GO:0032988)
0.0	0.1	GO:0032467	positive regulation of cytokinesis(GO:0032467)
0.0	0.1	GO:0034651	cortisol metabolic process(GO:0034650) cortisol biosynthetic process(GO:0034651)
0.0	0.1	GO:0046628	positive regulation of insulin receptor signaling pathway(GO:0046628) positive regulation of cellular response to insulin stimulus(GO:1900078)
0.0	0.0	GO:0009151	purine deoxyribonucleotide metabolic process(GO:0009151)
0.0	0.3	GO:0035329	hippo signaling(GO:0035329)
0.0	0.1	GO:0002903	negative regulation of B cell apoptotic process(GO:0002903)
0.0	0.1	GO:0015705	iodide transport(GO:0015705)
0.0	0.1	GO:0006391	transcription initiation from mitochondrial promoter(GO:0006391)
0.0	0.1	GO:0034393	positive regulation of muscle cell apoptotic process(GO:0010661) positive regulation of smooth muscle cell apoptotic process(GO:0034393)
0.0	0.1	GO:0001946	lymphangiogenesis(GO:0001946) lymph vessel morphogenesis(GO:0036303)
0.0	0.1	GO:0006533	aspartate metabolic process(GO:0006531) aspartate catabolic process(GO:0006533)
0.0	0.1	GO:0048755	branching morphogenesis of a nerve(GO:0048755)
0.0	0.0	GO:0060159	regulation of dopamine receptor signaling pathway(GO:0060159)
0.0	0.1	GO:0007144	female meiosis I(GO:0007144)
0.0	0.1	GO:0060009	Sertoli cell development(GO:0060009)
0.0	0.0	GO:0060174	limb bud formation(GO:0060174)
0.0	0.2	GO:0001542	ovulation from ovarian follicle(GO:0001542)
0.0	0.1	GO:0006610	ribosomal protein import into nucleus(GO:0006610)
0.0	0.0	GO:0007221	positive regulation of transcription of Notch receptor target(GO:0007221)
0.0	0.0	GO:0060594	mammary gland specification(GO:0060594)
0.0	0.1	GO:0006930	substrate-dependent cell migration, cell extension(GO:0006930)
0.0	0.1	GO:0045627	positive regulation of T-helper 1 cell differentiation(GO:0045627)
0.0	0.1	GO:0046520	sphingoid biosynthetic process(GO:0046520)
0.0	0.0	GO:0046049	UMP biosynthetic process(GO:0006222) pyrimidine ribonucleoside monophosphate metabolic process(GO:0009173) pyrimidine ribonucleoside monophosphate biosynthetic process(GO:0009174) UMP metabolic process(GO:0046049)
0.0	0.1	GO:0006927	obsolete transformed cell apoptotic process(GO:0006927)
0.0	0.0	GO:0043374	CD8-positive, alpha-beta T cell activation(GO:0036037) CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0	0.1	GO:0072386	plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.0	0.1	GO:0070050	neuron cellular homeostasis(GO:0070050)
0.0	0.1	GO:0007185	transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0	0.1	GO:0006398	mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.0	0.1	GO:0014012	peripheral nervous system axon regeneration(GO:0014012)
0.0	0.0	GO:0046882	negative regulation of follicle-stimulating hormone secretion(GO:0046882)
0.0	0.0	GO:0032413	negative regulation of ion transmembrane transporter activity(GO:0032413)
0.0	0.1	GO:0005981	regulation of glycogen catabolic process(GO:0005981)
0.0	0.1	GO:0003091	renal water homeostasis(GO:0003091)
0.0	0.0	GO:0061525	hindgut morphogenesis(GO:0007442) hindgut development(GO:0061525)
0.0	0.1	GO:0046426	negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0	0.1	GO:0016241	regulation of macroautophagy(GO:0016241)
0.0	0.0	GO:0072217	negative regulation of metanephros development(GO:0072217)
0.0	0.1	GO:0006295	nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295)
0.0	0.1	GO:0006527	arginine catabolic process(GO:0006527)
0.0	0.3	GO:0042474	middle ear morphogenesis(GO:0042474)
0.0	0.3	GO:0010171	body morphogenesis(GO:0010171)
0.0	0.1	GO:1903301	regulation of glucokinase activity(GO:0033131) positive regulation of glucokinase activity(GO:0033133) regulation of hexokinase activity(GO:1903299) positive regulation of hexokinase activity(GO:1903301)
0.0	0.1	GO:0002667	lymphocyte anergy(GO:0002249) regulation of T cell anergy(GO:0002667) positive regulation of T cell anergy(GO:0002669) T cell anergy(GO:0002870) regulation of lymphocyte anergy(GO:0002911) positive regulation of lymphocyte anergy(GO:0002913)
0.0	0.1	GO:0014912	negative regulation of smooth muscle cell migration(GO:0014912)
0.0	0.1	GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.0	0.1	GO:0021670	lateral ventricle development(GO:0021670)
0.0	0.0	GO:0072007	mesangial cell differentiation(GO:0072007) kidney interstitial fibroblast differentiation(GO:0072071) renal interstitial fibroblast development(GO:0072141) mesangial cell development(GO:0072143) pericyte cell differentiation(GO:1904238)
0.0	0.1	GO:0043461	proton-transporting ATP synthase complex assembly(GO:0043461) proton-transporting ATP synthase complex biogenesis(GO:0070272)
0.0	0.1	GO:0048840	otolith development(GO:0048840)
0.0	0.0	GO:0001554	luteolysis(GO:0001554)
0.0	0.1	GO:0060638	mesenchymal-epithelial cell signaling(GO:0060638)
0.0	0.1	GO:0031116	positive regulation of microtubule polymerization(GO:0031116)
0.0	0.4	GO:0016338	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.0	0.0	GO:0097709	connective tissue replacement involved in inflammatory response wound healing(GO:0002248) connective tissue replacement(GO:0097709)
0.0	0.0	GO:0080111	DNA demethylation(GO:0080111)
0.0	0.1	GO:0033600	negative regulation of mammary gland epithelial cell proliferation(GO:0033600)
0.0	0.1	GO:0009756	carbohydrate mediated signaling(GO:0009756)
0.0	0.1	GO:0006678	glucosylceramide metabolic process(GO:0006678)
0.0	0.0	GO:0000212	meiotic spindle organization(GO:0000212)
0.0	0.1	GO:0010966	regulation of phosphate transport(GO:0010966)
0.0	0.1	GO:0008300	isoprenoid catabolic process(GO:0008300)
0.0	0.1	GO:0031529	ruffle organization(GO:0031529)
0.0	0.1	GO:0043497	regulation of protein heterodimerization activity(GO:0043497)
0.0	0.1	GO:0007386	compartment pattern specification(GO:0007386)
0.0	0.1	GO:0070777	D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0	0.1	GO:0045077	negative regulation of interferon-gamma biosynthetic process(GO:0045077)
0.0	0.1	GO:0033173	calcineurin-NFAT signaling cascade(GO:0033173)
0.0	0.3	GO:0008038	neuron recognition(GO:0008038)
0.0	0.1	GO:0070296	sarcoplasmic reticulum calcium ion transport(GO:0070296)
0.0	0.0	GO:0034201	response to oleic acid(GO:0034201)
0.0	0.0	GO:0002043	blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.0	0.2	GO:0007016	cytoskeletal anchoring at plasma membrane(GO:0007016)
0.0	0.0	GO:0070634	transepithelial ammonium transport(GO:0070634)
0.0	0.1	GO:0009650	UV protection(GO:0009650)
0.0	0.1	GO:0009649	entrainment of circadian clock(GO:0009649)
0.0	0.0	GO:0006177	GMP biosynthetic process(GO:0006177)
0.0	0.1	GO:0016246	RNA interference(GO:0016246)
0.0	0.1	GO:0001885	endothelial cell development(GO:0001885)
0.0	0.0	GO:0048368	lateral mesoderm development(GO:0048368)
0.0	0.1	GO:0007258	JUN phosphorylation(GO:0007258)
0.0	0.4	GO:0010811	positive regulation of cell-substrate adhesion(GO:0010811)
0.0	0.1	GO:0031639	plasminogen activation(GO:0031639)
0.0	0.1	GO:0071549	cellular response to dexamethasone stimulus(GO:0071549)
0.0	0.0	GO:0060059	embryonic retina morphogenesis in camera-type eye(GO:0060059)
0.0	0.1	GO:0043383	negative T cell selection(GO:0043383)
0.0	0.1	GO:0060259	regulation of feeding behavior(GO:0060259)
0.0	0.0	GO:0006931	substrate-dependent cell migration, cell attachment to substrate(GO:0006931)
0.0	0.1	GO:0060708	spongiotrophoblast differentiation(GO:0060708)
0.0	0.1	GO:0021513	spinal cord dorsal/ventral patterning(GO:0021513)
0.0	0.1	GO:0042693	muscle cell fate commitment(GO:0042693)
0.0	0.1	GO:0048702	embryonic neurocranium morphogenesis(GO:0048702)
0.0	0.1	GO:0006269	DNA replication, synthesis of RNA primer(GO:0006269)
0.0	0.0	GO:0046813	receptor-mediated virion attachment to host cell(GO:0046813)
0.0	0.1	GO:0035414	negative regulation of catenin import into nucleus(GO:0035414)
0.0	0.0	GO:0003323	type B pancreatic cell development(GO:0003323)
0.0	0.0	GO:0045601	regulation of endothelial cell differentiation(GO:0045601)
0.0	0.0	GO:0051590	positive regulation of neurotransmitter transport(GO:0051590)
0.0	0.0	GO:0048861	leukemia inhibitory factor signaling pathway(GO:0048861)
0.0	0.1	GO:0009200	deoxyribonucleoside triphosphate metabolic process(GO:0009200)
0.0	0.0	GO:0042501	serine phosphorylation of STAT protein(GO:0042501)
0.0	0.0	GO:0002238	response to molecule of fungal origin(GO:0002238)
0.0	0.0	GO:0003283	atrial septum development(GO:0003283) atrial septum morphogenesis(GO:0060413)
0.0	0.1	GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518) negative regulation of signal transduction by p53 class mediator(GO:1901797)
0.0	0.0	GO:0048319	axial mesoderm morphogenesis(GO:0048319)
0.0	0.1	GO:0042415	norepinephrine metabolic process(GO:0042415)
0.0	0.0	GO:0021798	forebrain dorsal/ventral pattern formation(GO:0021798)
0.0	0.0	GO:0045002	DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792) double-strand break repair via single-strand annealing(GO:0045002)
0.0	0.1	GO:0031641	regulation of myelination(GO:0031641)
0.0	0.0	GO:0032780	negative regulation of ATPase activity(GO:0032780)
0.0	0.1	GO:0030866	cortical actin cytoskeleton organization(GO:0030866)
0.0	0.1	GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.0	0.0	GO:0010447	response to acidic pH(GO:0010447)
0.0	0.1	GO:0050919	negative chemotaxis(GO:0050919)
0.0	0.1	GO:0006498	N-terminal protein lipidation(GO:0006498)
0.0	0.1	GO:0032075	positive regulation of nuclease activity(GO:0032075)
0.0	0.1	GO:0050917	sensory perception of umami taste(GO:0050917)
0.0	0.2	GO:0007029	endoplasmic reticulum organization(GO:0007029)
0.0	0.0	GO:0071480	cellular response to gamma radiation(GO:0071480)
0.0	0.0	GO:0051307	resolution of meiotic recombination intermediates(GO:0000712) meiotic chromosome separation(GO:0051307)
0.0	0.0	GO:0060605	tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662)
0.0	0.0	GO:0072216	positive regulation of metanephros development(GO:0072216)
0.0	0.0	GO:0001945	lymph vessel development(GO:0001945)
0.0	0.1	GO:0009396	folic acid-containing compound biosynthetic process(GO:0009396)
0.0	0.2	GO:0060415	muscle tissue morphogenesis(GO:0060415)
0.0	0.1	GO:0007567	parturition(GO:0007567)
0.0	0.0	GO:0022617	extracellular matrix disassembly(GO:0022617)
0.0	0.0	GO:0019856	'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) pyrimidine nucleobase biosynthetic process(GO:0019856)
0.0	0.0	GO:0071028	RNA surveillance(GO:0071025) nuclear RNA surveillance(GO:0071027) nuclear mRNA surveillance(GO:0071028)
0.0	0.0	GO:0036072	intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.0	0.1	GO:0006707	cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.0	0.1	GO:0071044	histone mRNA catabolic process(GO:0071044)
0.0	0.1	GO:1901796	regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043516) regulation of signal transduction by p53 class mediator(GO:1901796)
0.0	0.0	GO:0002023	reduction of food intake in response to dietary excess(GO:0002023)
0.0	0.2	GO:0050819	negative regulation of coagulation(GO:0050819)
0.0	0.0	GO:0070307	lens fiber cell development(GO:0070307)
0.0	0.1	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771)
0.0	0.0	GO:0002246	wound healing involved in inflammatory response(GO:0002246) smooth muscle adaptation(GO:0014805) inflammatory response to wounding(GO:0090594)
0.0	0.0	GO:0002858	natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002420) natural killer cell mediated immune response to tumor cell(GO:0002423) regulation of natural killer cell mediated immune response to tumor cell(GO:0002855) positive regulation of natural killer cell mediated immune response to tumor cell(GO:0002857) regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002858) positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002860)
0.0	0.0	GO:0010225	response to UV-C(GO:0010225)
0.0	0.0	GO:0071034	CUT catabolic process(GO:0071034) CUT metabolic process(GO:0071043)
0.0	0.0	GO:0031536	positive regulation of exit from mitosis(GO:0031536)
0.0	0.0	GO:0045046	protein import into peroxisome membrane(GO:0045046)
0.0	0.0	GO:0060426	lung vasculature development(GO:0060426)
0.0	0.0	GO:0051305	chromosome movement towards spindle pole(GO:0051305)
0.0	0.1	GO:0045008	depyrimidination(GO:0045008)
0.0	0.0	GO:0001976	neurological system process involved in regulation of systemic arterial blood pressure(GO:0001976)
0.0	0.1	GO:0010633	negative regulation of epithelial cell migration(GO:0010633)
0.0	0.0	GO:0045056	transcytosis(GO:0045056)
0.0	0.1	GO:0034314	Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.0	0.0	GO:0007500	mesodermal cell fate determination(GO:0007500)
0.0	0.0	GO:0000491	small nucleolar ribonucleoprotein complex assembly(GO:0000491) box C/D snoRNP assembly(GO:0000492)
0.0	0.0	GO:0007008	outer mitochondrial membrane organization(GO:0007008) protein import into mitochondrial outer membrane(GO:0045040)
0.0	0.1	GO:0006703	estrogen biosynthetic process(GO:0006703)
0.0	0.0	GO:0006435	threonyl-tRNA aminoacylation(GO:0006435)
0.0	0.0	GO:0033505	floor plate morphogenesis(GO:0033505)
0.0	0.1	GO:0018345	protein palmitoylation(GO:0018345)
0.0	0.0	GO:0043312	neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312)
0.0	0.0	GO:0019511	peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) 4-hydroxyproline metabolic process(GO:0019471) peptidyl-proline hydroxylation(GO:0019511)
0.0	0.1	GO:0006264	mitochondrial DNA replication(GO:0006264)
0.0	0.0	GO:0030728	ovulation(GO:0030728)
0.0	0.0	GO:0007598	blood coagulation, extrinsic pathway(GO:0007598)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.1	GO:0071664	catenin-TCF7L2 complex(GO:0071664)
0.1	0.2	GO:0030934	anchoring collagen complex(GO:0030934)
0.1	0.5	GO:0005614	interstitial matrix(GO:0005614)
0.0	0.4	GO:0030127	COPII vesicle coat(GO:0030127)
0.0	0.5	GO:0098878	ionotropic glutamate receptor complex(GO:0008328) neurotransmitter receptor complex(GO:0098878)
0.0	0.2	GO:0071437	invadopodium(GO:0071437)
0.0	0.2	GO:0098645	network-forming collagen trimer(GO:0098642) collagen network(GO:0098645)
0.0	0.1	GO:0005589	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0	0.1	GO:0032449	CBM complex(GO:0032449)
0.0	0.2	GO:0031362	anchored component of external side of plasma membrane(GO:0031362)
0.0	0.1	GO:0031265	CD95 death-inducing signaling complex(GO:0031265)
0.0	0.0	GO:0098651	basement membrane collagen trimer(GO:0098651)
0.0	0.3	GO:0014704	intercalated disc(GO:0014704) cell-cell contact zone(GO:0044291)
0.0	0.1	GO:0000176	nuclear exosome (RNase complex)(GO:0000176)
0.0	0.2	GO:0005606	laminin-1 complex(GO:0005606)
0.0	0.6	GO:0001725	stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0	0.1	GO:0016533	cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.0	0.1	GO:0005641	nuclear envelope lumen(GO:0005641)
0.0	0.2	GO:0030122	AP-2 adaptor complex(GO:0030122) clathrin coat of endocytic vesicle(GO:0030128)
0.0	0.1	GO:0017059	palmitoyltransferase complex(GO:0002178) serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0	0.1	GO:0036454	insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454)
0.0	0.0	GO:0005899	insulin receptor complex(GO:0005899)
0.0	0.5	GO:0005581	collagen trimer(GO:0005581)
0.0	0.2	GO:0005847	mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0	0.3	GO:0032391	photoreceptor connecting cilium(GO:0032391)
0.0	0.1	GO:0001940	male pronucleus(GO:0001940)
0.0	0.0	GO:0060200	clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201)
0.0	0.3	GO:0005913	cell-cell adherens junction(GO:0005913)
0.0	0.1	GO:0045298	tubulin complex(GO:0045298)
0.0	0.1	GO:0005861	troponin complex(GO:0005861)
0.0	0.2	GO:0016281	eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0	0.1	GO:0033018	sarcoplasmic reticulum lumen(GO:0033018)
0.0	0.1	GO:0071256	Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.0	1.3	GO:0070160	bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.0	0.3	GO:0005811	lipid particle(GO:0005811)
0.0	0.1	GO:0042587	glycogen granule(GO:0042587)
0.0	0.0	GO:0043083	synaptic cleft(GO:0043083)
0.0	0.1	GO:0005832	chaperonin-containing T-complex(GO:0005832)
0.0	0.3	GO:0031594	neuromuscular junction(GO:0031594)
0.0	0.0	GO:0070083	clathrin-sculpted monoamine transport vesicle(GO:0070081) clathrin-sculpted monoamine transport vesicle membrane(GO:0070083)
0.0	0.0	GO:0071062	alphav-beta3 integrin-vitronectin complex(GO:0071062)
0.0	0.0	GO:0031931	TORC1 complex(GO:0031931)
0.0	0.1	GO:0016012	dystroglycan complex(GO:0016011) sarcoglycan complex(GO:0016012)
0.0	0.2	GO:0030134	ER to Golgi transport vesicle(GO:0030134)
0.0	0.1	GO:0030315	T-tubule(GO:0030315)
0.0	0.7	GO:0034707	chloride channel complex(GO:0034707)
0.0	0.1	GO:0031512	motile primary cilium(GO:0031512)
0.0	0.0	GO:0045254	pyruvate dehydrogenase complex(GO:0045254)
0.0	0.7	GO:0030426	growth cone(GO:0030426)
0.0	0.1	GO:0032838	cell projection cytoplasm(GO:0032838)
0.0	0.0	GO:0034363	intermediate-density lipoprotein particle(GO:0034363)
0.0	0.0	GO:0008282	ATP-sensitive potassium channel complex(GO:0008282)
0.0	0.0	GO:0030121	AP-1 adaptor complex(GO:0030121)
0.0	0.0	GO:0005787	signal peptidase complex(GO:0005787)
0.0	0.1	GO:0031463	Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0	1.0	GO:0005925	focal adhesion(GO:0005925)
0.0	0.1	GO:0032389	MutLalpha complex(GO:0032389)
0.0	0.1	GO:0008385	IkappaB kinase complex(GO:0008385)
0.0	0.1	GO:0031527	filopodium membrane(GO:0031527)
0.0	0.0	GO:0030056	hemidesmosome(GO:0030056)
0.0	0.1	GO:0034464	BBSome(GO:0034464)
0.0	0.1	GO:0035253	ciliary rootlet(GO:0035253)
0.0	0.1	GO:0043205	fibril(GO:0043205)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0050508	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.1	0.3	GO:0005127	ciliary neurotrophic factor receptor binding(GO:0005127)
0.1	0.4	GO:0005010	insulin-like growth factor-activated receptor activity(GO:0005010)
0.1	0.2	GO:0004687	myosin light chain kinase activity(GO:0004687)
0.1	0.5	GO:0017154	semaphorin receptor activity(GO:0017154)
0.1	0.2	GO:0015204	urea transmembrane transporter activity(GO:0015204)
0.1	0.1	GO:0045159	myosin II binding(GO:0045159)
0.1	0.2	GO:0070324	thyroid hormone binding(GO:0070324)
0.1	0.4	GO:0015277	kainate selective glutamate receptor activity(GO:0015277)
0.1	0.3	GO:0042153	obsolete RPTP-like protein binding(GO:0042153)
0.1	0.4	GO:0042805	actinin binding(GO:0042805)
0.1	0.2	GO:0004800	thyroxine 5'-deiodinase activity(GO:0004800)
0.0	0.2	GO:0019211	phosphatase activator activity(GO:0019211)
0.0	0.1	GO:0004321	fatty-acyl-CoA synthase activity(GO:0004321)
0.0	0.3	GO:0005172	vascular endothelial growth factor receptor binding(GO:0005172)
0.0	0.1	GO:0030215	semaphorin receptor binding(GO:0030215)
0.0	0.1	GO:0060230	lipoprotein lipase activator activity(GO:0060230)
0.0	0.2	GO:0030297	transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.0	0.1	GO:0005006	epidermal growth factor-activated receptor activity(GO:0005006)
0.0	0.2	GO:0016934	extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.0	0.4	GO:0048407	platelet-derived growth factor binding(GO:0048407)
0.0	0.1	GO:0030151	molybdenum ion binding(GO:0030151)
0.0	0.1	GO:0004758	serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0	0.2	GO:0043274	phospholipase binding(GO:0043274)
0.0	0.3	GO:0047498	calcium-dependent phospholipase A2 activity(GO:0047498)
0.0	0.1	GO:0035514	DNA demethylase activity(GO:0035514) DNA-N1-methyladenine dioxygenase activity(GO:0043734)
0.0	0.1	GO:0050253	retinyl-palmitate esterase activity(GO:0050253)
0.0	0.1	GO:0003831	beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity(GO:0003831)
0.0	0.1	GO:0003896	DNA primase activity(GO:0003896)
0.0	0.1	GO:0031544	procollagen-proline 3-dioxygenase activity(GO:0019797) peptidyl-proline 3-dioxygenase activity(GO:0031544)
0.0	0.1	GO:0004448	isocitrate dehydrogenase activity(GO:0004448)
0.0	0.3	GO:0004859	phospholipase inhibitor activity(GO:0004859)
0.0	0.1	GO:0005432	calcium:sodium antiporter activity(GO:0005432)
0.0	0.1	GO:0003680	AT DNA binding(GO:0003680)
0.0	0.0	GO:0070273	phosphatidylinositol-4-phosphate binding(GO:0070273)
0.0	0.1	GO:0004985	opioid receptor activity(GO:0004985)
0.0	0.6	GO:0008093	cytoskeletal adaptor activity(GO:0008093)
0.0	0.1	GO:0015142	citrate transmembrane transporter activity(GO:0015137) tricarboxylic acid transmembrane transporter activity(GO:0015142)
0.0	0.1	GO:0004117	calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117)
0.0	0.1	GO:0033829	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.0	0.1	GO:0042608	T cell receptor binding(GO:0042608)
0.0	0.1	GO:0008475	procollagen-lysine 5-dioxygenase activity(GO:0008475)
0.0	0.1	GO:0033765	steroid dehydrogenase activity, acting on the CH-CH group of donors(GO:0033765)
0.0	0.1	GO:0004597	peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.0	0.2	GO:0046965	retinoid X receptor binding(GO:0046965)
0.0	0.1	GO:0004645	phosphorylase activity(GO:0004645)
0.0	0.0	GO:0050431	transforming growth factor beta binding(GO:0050431)
0.0	0.0	GO:0045545	syndecan binding(GO:0045545)
0.0	0.1	GO:0070053	thrombospondin receptor activity(GO:0070053)
0.0	0.1	GO:0070095	fructose-6-phosphate binding(GO:0070095)
0.0	0.1	GO:0005111	type 2 fibroblast growth factor receptor binding(GO:0005111)
0.0	0.1	GO:0004720	protein-lysine 6-oxidase activity(GO:0004720)
0.0	0.1	GO:0004965	G-protein coupled GABA receptor activity(GO:0004965)
0.0	0.0	GO:0005105	type 1 fibroblast growth factor receptor binding(GO:0005105)
0.0	0.1	GO:0016909	JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0	0.8	GO:0005518	collagen binding(GO:0005518)
0.0	0.0	GO:0005017	platelet-derived growth factor-activated receptor activity(GO:0005017)
0.0	0.1	GO:0008253	5'-nucleotidase activity(GO:0008253)
0.0	0.1	GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.0	0.0	GO:0046975	histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.0	0.2	GO:0004029	aldehyde dehydrogenase (NAD) activity(GO:0004029)
0.0	0.1	GO:0010314	phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0	0.1	GO:0004157	dihydropyrimidinase activity(GO:0004157)
0.0	0.1	GO:0003696	satellite DNA binding(GO:0003696)
0.0	0.1	GO:0030284	estrogen receptor activity(GO:0030284)
0.0	0.1	GO:0001517	N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517)
0.0	0.2	GO:0016641	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641)
0.0	0.2	GO:0071617	1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) lysophosphatidic acid acyltransferase activity(GO:0042171) lysophospholipid acyltransferase activity(GO:0071617)
0.0	0.1	GO:0008510	sodium:bicarbonate symporter activity(GO:0008510)
0.0	0.1	GO:0015166	polyol transmembrane transporter activity(GO:0015166)
0.0	0.1	GO:0030618	transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0	0.2	GO:0030247	pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0	0.1	GO:0003876	AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0	0.1	GO:0033130	acetylcholine receptor binding(GO:0033130)
0.0	0.2	GO:0051010	microtubule plus-end binding(GO:0051010)
0.0	0.1	GO:0000900	translation repressor activity, nucleic acid binding(GO:0000900)
0.0	0.1	GO:0050501	hyaluronan synthase activity(GO:0050501)
0.0	0.1	GO:0048495	Roundabout binding(GO:0048495)
0.0	0.1	GO:0016421	CoA carboxylase activity(GO:0016421)
0.0	0.0	GO:0050698	proteoglycan sulfotransferase activity(GO:0050698)
0.0	0.0	GO:0016623	oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor(GO:0016623)
0.0	0.0	GO:0070411	I-SMAD binding(GO:0070411)
0.0	0.1	GO:0043539	protein serine/threonine kinase activator activity(GO:0043539)
0.0	0.0	GO:0050265	RNA uridylyltransferase activity(GO:0050265)
0.0	0.0	GO:0005534	galactose binding(GO:0005534)
0.0	0.1	GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.0	0.1	GO:0005143	interleukin-12 receptor binding(GO:0005143)
0.0	0.1	GO:0004470	malic enzyme activity(GO:0004470)
0.0	0.1	GO:0000014	single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.0	0.1	GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717)
0.0	0.1	GO:0030172	troponin C binding(GO:0030172)
0.0	0.0	GO:0043008	ATP-dependent protein binding(GO:0043008)
0.0	0.1	GO:0016411	acylglycerol O-acyltransferase activity(GO:0016411)
0.0	0.0	GO:0070653	high-density lipoprotein particle receptor binding(GO:0070653)
0.0	0.0	GO:0003945	N-acetyllactosamine synthase activity(GO:0003945)
0.0	0.0	GO:0017112	Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0	0.1	GO:0005337	nucleoside transmembrane transporter activity(GO:0005337)
0.0	0.1	GO:0034235	GPI anchor binding(GO:0034235)
0.0	0.1	GO:0070016	armadillo repeat domain binding(GO:0070016)
0.0	0.1	GO:0043395	heparan sulfate proteoglycan binding(GO:0043395)
0.0	0.1	GO:0030955	potassium ion binding(GO:0030955)
0.0	0.0	GO:0050656	3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
0.0	0.0	GO:0070569	uridylyltransferase activity(GO:0070569)
0.0	0.1	GO:0005314	high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.0	0.0	GO:0050897	cobalt ion binding(GO:0050897)
0.0	0.0	GO:0061505	DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.0	0.0	GO:0016151	nickel cation binding(GO:0016151)
0.0	0.0	GO:0031127	galactoside 2-alpha-L-fucosyltransferase activity(GO:0008107) alpha-(1,2)-fucosyltransferase activity(GO:0031127)
0.0	0.0	GO:0004924	oncostatin-M receptor activity(GO:0004924)
0.0	0.0	GO:0015272	ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.0	0.2	GO:0004683	calmodulin-dependent protein kinase activity(GO:0004683)
0.0	0.1	GO:0030250	cyclase activator activity(GO:0010853) guanylate cyclase activator activity(GO:0030250)
0.0	0.1	GO:0042605	peptide antigen binding(GO:0042605)
0.0	0.1	GO:0015280	ligand-gated sodium channel activity(GO:0015280)
0.0	0.0	GO:0004948	calcitonin receptor activity(GO:0004948)
0.0	0.2	GO:0008200	ion channel inhibitor activity(GO:0008200)
0.0	0.1	GO:0003785	actin monomer binding(GO:0003785)
0.0	0.2	GO:0004675	transmembrane receptor protein serine/threonine kinase activity(GO:0004675)
0.0	0.1	GO:0070063	RNA polymerase binding(GO:0070063)
0.0	0.0	GO:0004829	threonine-tRNA ligase activity(GO:0004829)
0.0	0.1	GO:0008190	eukaryotic initiation factor 4E binding(GO:0008190)
0.0	0.0	GO:0042285	UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285)
0.0	0.1	GO:0034483	heparan sulfate sulfotransferase activity(GO:0034483)
0.0	0.1	GO:0008409	5'-3' exonuclease activity(GO:0008409)
0.0	0.1	GO:0047372	acylglycerol lipase activity(GO:0047372)
0.0	0.1	GO:0015174	basic amino acid transmembrane transporter activity(GO:0015174)
0.0	0.1	GO:0031369	translation initiation factor binding(GO:0031369)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.7	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
0.0	0.1	PID TXA2PATHWAY	Thromboxane A2 receptor signaling
0.0	0.1	PID AVB3 OPN PATHWAY	Osteopontin-mediated events
0.0	1.2	NABA COLLAGENS	Genes encoding collagen proteins
0.0	0.1	PID NEPHRIN NEPH1 PATHWAY	Nephrin/Neph1 signaling in the kidney podocyte
0.0	0.0	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
0.0	0.3	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0	0.0	PID SYNDECAN 4 PATHWAY	Syndecan-4-mediated signaling events
0.0	0.3	PID INTEGRIN3 PATHWAY	Beta3 integrin cell surface interactions
0.0	0.4	PID UPA UPAR PATHWAY	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0	0.0	ST ADRENERGIC	Adrenergic Pathway
0.0	0.1	ST DIFFERENTIATION PATHWAY IN PC12 CELLS	Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.0	0.0	PID GLYPICAN 1PATHWAY	Glypican 1 network
0.0	0.1	PID S1P S1P1 PATHWAY	S1P1 pathway
0.0	0.2	PID LPA4 PATHWAY	LPA4-mediated signaling events
0.0	0.3	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor
0.0	0.1	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0	0.2	PID RET PATHWAY	Signaling events regulated by Ret tyrosine kinase
0.0	0.1	PID INTEGRIN1 PATHWAY	Beta1 integrin cell surface interactions
0.0	0.4	PID ECADHERIN STABILIZATION PATHWAY	Stabilization and expansion of the E-cadherin adherens junction
0.0	0.3	PID LIS1 PATHWAY	Lissencephaly gene (LIS1) in neuronal migration and development
0.0	0.3	PID EPHB FWD PATHWAY	EPHB forward signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.1	REACTOME PLC BETA MEDIATED EVENTS	Genes involved in PLC beta mediated events
0.1	0.7	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.0	0.1	REACTOME SOS MEDIATED SIGNALLING	Genes involved in SOS-mediated signalling
0.0	0.4	REACTOME MTORC1 MEDIATED SIGNALLING	Genes involved in mTORC1-mediated signalling
0.0	0.4	REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	Genes involved in DCC mediated attractive signaling
0.0	0.0	REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII	Genes involved in CREB phosphorylation through the activation of CaMKII
0.0	0.4	REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION	Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.0	0.8	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.0	0.0	REACTOME ALPHA LINOLENIC ACID ALA METABOLISM	Genes involved in alpha-linolenic acid (ALA) metabolism
0.0	1.4	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.0	0.5	REACTOME SIGNALING BY HIPPO	Genes involved in Signaling by Hippo
0.0	0.5	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.0	0.3	REACTOME ACYL CHAIN REMODELLING OF PS	Genes involved in Acyl chain remodelling of PS
0.0	0.6	REACTOME HS GAG BIOSYNTHESIS	Genes involved in HS-GAG biosynthesis
0.0	0.4	REACTOME SIGNALING BY BMP	Genes involved in Signaling by BMP
0.0	0.1	REACTOME FRS2 MEDIATED CASCADE	Genes involved in FRS2-mediated cascade
0.0	0.0	REACTOME BILE ACID AND BILE SALT METABOLISM	Genes involved in Bile acid and bile salt metabolism
0.0	0.3	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0	0.2	REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Glutamate Neurotransmitter Release Cycle
0.0	0.2	REACTOME PURINE CATABOLISM	Genes involved in Purine catabolism
0.0	0.2	REACTOME HYALURONAN UPTAKE AND DEGRADATION	Genes involved in Hyaluronan uptake and degradation
0.0	0.2	REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY	Genes involved in Adenylate cyclase inhibitory pathway
0.0	0.4	REACTOME CELL CELL JUNCTION ORGANIZATION	Genes involved in Cell-cell junction organization
0.0	0.0	REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Dopamine Neurotransmitter Release Cycle
0.0	0.1	REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR	Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0	0.1	REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS	Genes involved in Membrane binding and targetting of GAG proteins
0.0	0.1	REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1	Genes involved in IKK complex recruitment mediated by RIP1
0.0	0.2	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.0	0.0	REACTOME SIGNALING BY FGFR3 MUTANTS	Genes involved in Signaling by FGFR3 mutants
0.0	0.0	REACTOME HYALURONAN METABOLISM	Genes involved in Hyaluronan metabolism
0.0	0.1	REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES	Genes involved in p75NTR recruits signalling complexes
0.0	0.3	REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS	Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0	0.2	REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0	0.1	REACTOME PRE NOTCH PROCESSING IN GOLGI	Genes involved in Pre-NOTCH Processing in Golgi