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ENCODE: H3K4me1 ChIP-Seq of primary human cells
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Results for RORA

Z-value: 1.64

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Transcription factors associated with RORA

Gene Symbol Gene ID Gene Info
ENSG00000069667.11 RAR related orphan receptor A

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr15_60883775_60883968RORA8690.664381-0.891.5e-03Click!
chr15_60885332_60885500RORA910.977330-0.791.0e-02Click!
chr15_60936882_60937033RORA172950.2066260.742.3e-02Click!
chr15_60884114_60884267RORA5500.812497-0.732.4e-02Click!
chr15_60902634_60902785RORA169340.216934-0.703.5e-02Click!

Activity of the RORA motif across conditions

Conditions sorted by the z-value of the RORA motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr12_50611338_50611602 0.62 RP3-405J10.4

1917
0.22
chr9_18437920_18438071 0.57 ADAMTSL1
ADAMTS-like 1
35897
0.23
chr17_39217082_39217233 0.56 KRTAP2-3
keratin associated protein 2-3
813
0.31
chr9_89990192_89990343 0.56 ENSG00000212421
.
114902
0.06
chr17_73872544_73873300 0.54 TRIM47
tripartite motif containing 47
423
0.43
chr18_24196978_24197129 0.54 KCTD1
potassium channel tetramerization domain containing 1
12153
0.2
chr9_83646594_83646895 0.54 ENSG00000221581
.
297500
0.01
chr3_149738658_149738809 0.54 PFN2
profilin 2
1865
0.34
chr6_140382856_140383007 0.53 ENSG00000252107
.
96900
0.09
chr5_150025102_150025253 0.53 SYNPO
synaptopodin
4937
0.16
chr2_9571047_9571198 0.53 CPSF3
cleavage and polyadenylation specific factor 3, 73kDa
7109
0.19
chr10_115234705_115234856 0.52 HABP2
hyaluronan binding protein 2
75816
0.11
chr5_53683581_53683732 0.52 HSPB3
heat shock 27kDa protein 3
67789
0.12
chr1_68403039_68403338 0.52 GNG12-AS1
GNG12 antisense RNA 1
17900
0.24
chr6_57129918_57130069 0.51 RAB23
RAB23, member RAS oncogene family
42915
0.15
chr2_9777860_9778099 0.51 YWHAQ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
6836
0.21
chr14_86031688_86031839 0.51 FLRT2
fibronectin leucine rich transmembrane protein 2
35191
0.2
chr6_37423751_37423902 0.50 CMTR1
cap methyltransferase 1
19269
0.19
chr1_20390393_20390544 0.50 PLA2G5
phospholipase A2, group V
6233
0.2
chr2_19323725_19323876 0.49 ENSG00000266738
.
224390
0.02
chr1_64991178_64991359 0.49 ENSG00000264470
.
54262
0.14
chr2_33294539_33294812 0.49 LTBP1
latent transforming growth factor beta binding protein 1
64798
0.12
chr4_96028162_96028313 0.48 BMPR1B
bone morphogenetic protein receptor, type IB
2731
0.44
chr5_33612837_33612988 0.48 TARS
threonyl-tRNA synthetase
171425
0.03
chr8_117600503_117600654 0.48 EIF3H
eukaryotic translation initiation factor 3, subunit H
167445
0.03
chr16_66416650_66416801 0.47 CDH5
cadherin 5, type 2 (vascular endothelium)
3597
0.24
chr11_9191471_9191622 0.47 DENND5A
DENN/MADD domain containing 5A
2246
0.32
chr16_65151739_65151890 0.47 CDH11
cadherin 11, type 2, OB-cadherin (osteoblast)
4019
0.39
chr5_145356260_145356548 0.46 SH3RF2
SH3 domain containing ring finger 2
38964
0.18
chr3_187952552_187952703 0.46 LPP
LIM domain containing preferred translocation partner in lipoma
5025
0.29
chr18_8213240_8213391 0.46 ENSG00000212067
.
13868
0.23
chr12_69927570_69927949 0.46 FRS2
fibroblast growth factor receptor substrate 2
3156
0.27
chr3_66033537_66033688 0.45 MAGI1
membrane associated guanylate kinase, WW and PDZ domain containing 1
9387
0.23
chr9_6567455_6567606 0.45 ENSG00000252110
.
1105
0.53
chr20_10829555_10829706 0.45 RP11-103J8.1

53302
0.17
chr19_17422479_17422790 0.45 ABHD8
abhydrolase domain containing 8
1589
0.16
chr8_119065102_119065253 0.44 EXT1
exostosin glycosyltransferase 1
57476
0.17
chr3_50285847_50286499 0.43 GNAI2
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
1847
0.19
chr19_2149731_2150754 0.43 AP3D1
adaptor-related protein complex 3, delta 1 subunit
1297
0.32
chr11_12821990_12822259 0.43 RP11-47J17.3

23090
0.19
chr10_79743394_79743545 0.43 POLR3A
polymerase (RNA) III (DNA directed) polypeptide A, 155kDa
45834
0.12
chr3_138188194_138188345 0.43 CEP70
centrosomal protein 70kDa
30753
0.18
chr13_76345505_76345656 0.43 LMO7
LIM domain 7
10783
0.26
chr3_114161428_114161579 0.42 ZBTB20
zinc finger and BTB domain containing 20
12027
0.25
chr1_203503489_203503640 0.42 OPTC
opticin
38466
0.16
chr6_41065063_41065214 0.42 OARD1
O-acyl-ADP-ribose deacylase 1
359
0.81
chr20_60735818_60735969 0.42 SS18L1
synovial sarcoma translocation gene on chromosome 18-like 1
2049
0.25
chr1_118229559_118229710 0.42 ENSG00000212266
.
1730
0.47
chr3_106927449_106927600 0.42 ENSG00000220989
.
156505
0.04
chr1_85805849_85806000 0.42 ENSG00000264380
.
55631
0.09
chr15_85888485_85888636 0.42 AKAP13
A kinase (PRKA) anchor protein 13
35258
0.15
chr8_123868137_123868288 0.42 ZHX2
zinc fingers and homeoboxes 2
7412
0.2
chr16_69074448_69074599 0.41 ENSG00000202497
.
33465
0.14
chr5_138397564_138397715 0.41 SIL1
SIL1 nucleotide exchange factor
19268
0.18
chr15_74232933_74233272 0.41 LOXL1-AS1
LOXL1 antisense RNA 1
12513
0.14
chr12_26148588_26148739 0.41 RASSF8
Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
726
0.74
chr4_160281542_160281693 0.41 RAPGEF2
Rap guanine nucleotide exchange factor (GEF) 2
10237
0.27
chr17_36620738_36620994 0.41 ARHGAP23
Rho GTPase activating protein 23
7222
0.17
chr4_73836894_73837045 0.40 ENSG00000252955
.
6074
0.28
chr13_33700338_33700489 0.40 STARD13-IT1
STARD13 intronic transcript 1 (non-protein coding)
38133
0.17
chr8_8522351_8522502 0.40 ENSG00000264445
.
31452
0.18
chr5_152869678_152869829 0.40 GRIA1
glutamate receptor, ionotropic, AMPA 1
353
0.94
chr7_151200413_151200564 0.40 RHEB
Ras homolog enriched in brain
14667
0.16
chr2_150451982_150452133 0.40 MMADHC
methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria
7727
0.21
chr2_74004592_74004743 0.40 DUSP11
dual specificity phosphatase 11 (RNA/RNP complex 1-interacting)
2428
0.25
chr17_65214980_65215131 0.40 RP11-401F2.4

5364
0.17
chr12_4140465_4141124 0.39 RP11-664D1.1

126408
0.05
chr6_143591799_143591950 0.39 AIG1
androgen-induced 1
144487
0.04
chr8_124656767_124656918 0.39 KLHL38
kelch-like family member 38
8348
0.2
chr16_4263907_4264209 0.39 SRL
sarcalumenin
25686
0.16
chr1_178209193_178209344 0.39 RASAL2
RAS protein activator like 2
101338
0.08
chr14_96556907_96557058 0.39 C14orf132
chromosome 14 open reading frame 132
386
0.88
chr2_46542032_46542183 0.38 EPAS1
endothelial PAS domain protein 1
17566
0.25
chr4_15454262_15454413 0.38 CC2D2A
coiled-coil and C2 domain containing 2A
17152
0.16
chr5_112417198_112417349 0.38 DCP2
decapping mRNA 2
104794
0.06
chr10_114846149_114846300 0.38 TCF7L2
transcription factor 7-like 2 (T-cell specific, HMG-box)
57455
0.15
chr6_76147282_76147433 0.38 ENSG00000263533
.
9234
0.18
chr11_63440539_63440690 0.38 ATL3
atlastin GTPase 3
1221
0.4
chr16_82787297_82787448 0.38 RP11-22H5.2

19552
0.24
chr14_25580776_25580927 0.38 STXBP6
syntaxin binding protein 6 (amisyn)
61348
0.15
chr11_118491249_118491656 0.38 PHLDB1
pleckstrin homology-like domain, family B, member 1
13094
0.11
chr1_93405805_93405956 0.38 FAM69A
family with sequence similarity 69, member A
21177
0.12
chr1_159567510_159567661 0.38 APCS
amyloid P component, serum
9970
0.22
chr3_192603097_192603248 0.38 MB21D2
Mab-21 domain containing 2
32778
0.23
chr14_100275563_100275795 0.38 EML1
echinoderm microtubule associated protein like 1
109
0.98
chr20_13010496_13010647 0.37 SPTLC3
serine palmitoyltransferase, long chain base subunit 3
20574
0.28
chr3_54897591_54897742 0.37 CACNA2D3-AS1
CACNA2D3 antisense RNA 1
37616
0.21
chr6_140247827_140247978 0.37 ENSG00000252107
.
231929
0.02
chr11_91863154_91863305 0.37 FAT3
FAT atypical cadherin 3
222033
0.02
chr11_100746918_100747069 0.37 ENSG00000200047
.
36632
0.15
chr2_190700976_190701127 0.37 PMS1
PMS1 postmeiotic segregation increased 1 (S. cerevisiae)
18198
0.15
chr15_62737179_62737605 0.37 TLN2
talin 2
116172
0.06
chr13_32368184_32368335 0.37 RXFP2
relaxin/insulin-like family peptide receptor 2
54580
0.17
chr5_102808188_102808485 0.36 NUDT12
nudix (nucleoside diphosphate linked moiety X)-type motif 12
90154
0.1
chr5_101963356_101963507 0.36 RP11-58B2.1

122458
0.06
chr19_48991020_48991171 0.36 CYTH2
cytohesin 2
15486
0.09
chr3_189428781_189428932 0.36 TP63
tumor protein p63
78593
0.11
chr10_60766507_60766658 0.36 ENSG00000252076
.
137638
0.05
chr22_40998121_40998272 0.36 MKL1
megakaryoblastic leukemia (translocation) 1
34493
0.16
chr16_83437863_83438014 0.36 ENSG00000222299
.
3718
0.27
chr7_34082557_34082708 0.36 BMPER
BMP binding endothelial regulator
137487
0.05
chr8_96653162_96653313 0.36 ENSG00000223297
.
37906
0.19
chr1_12483776_12483927 0.35 VPS13D
vacuolar protein sorting 13 homolog D (S. cerevisiae)
13927
0.23
chr2_205370374_205370525 0.35 PARD3B
par-3 family cell polarity regulator beta
40067
0.23
chr21_47480957_47481280 0.35 AP001471.1

36326
0.12
chr10_71567463_71567614 0.35 ENSG00000222631
.
4913
0.22
chr8_69766358_69766509 0.35 ENSG00000239184
.
158555
0.04
chr4_54643319_54643470 0.35 LNX1
ligand of numb-protein X 1, E3 ubiquitin protein ligase
75822
0.1
chr18_43209000_43209203 0.35 SLC14A2
solute carrier family 14 (urea transporter), member 2
14335
0.2
chr9_111799017_111799168 0.35 ENSG00000199331
.
5675
0.16
chr3_55208193_55208344 0.35 LRTM1
leucine-rich repeats and transmembrane domains 1
207153
0.03
chr2_153370502_153370653 0.35 FMNL2
formin-like 2
105515
0.08
chr6_35364753_35364904 0.35 PPARD
peroxisome proliferator-activated receptor delta
54426
0.1
chr10_114807131_114807282 0.35 RP11-57H14.2

95572
0.08
chr9_72664551_72664702 0.35 MAMDC2
MAM domain containing 2
6129
0.26
chr14_93701710_93701861 0.35 UBR7
ubiquitin protein ligase E3 component n-recognin 7 (putative)
16758
0.14
chr11_116705965_116706733 0.35 APOA1-AS
APOA1 antisense RNA
484
0.63
chr10_128087058_128087209 0.35 ADAM12
ADAM metallopeptidase domain 12
10109
0.27
chr11_102048059_102048210 0.35 YAP1
Yes-associated protein 1
8678
0.21
chr3_189491567_189491718 0.35 TP63
tumor protein p63
15807
0.26
chr10_98574486_98574637 0.34 ENSG00000207976
.
13960
0.18
chr14_89302209_89302360 0.34 ENSG00000207342
.
4225
0.2
chr1_201679077_201679228 0.34 ENSG00000264802
.
9484
0.13
chr2_43152776_43153425 0.34 HAAO
3-hydroxyanthranilate 3,4-dioxygenase
133368
0.05
chr7_47803470_47803621 0.34 LINC00525
long intergenic non-protein coding RNA 525
598
0.78
chr18_8231250_8231401 0.34 ENSG00000212067
.
4142
0.29
chr10_79291019_79291170 0.34 ENSG00000199592
.
55713
0.15
chr9_13939488_13939639 0.34 NFIB
nuclear factor I/B
241228
0.02
chr8_29368707_29368858 0.34 RP4-676L2.1

158095
0.04
chr15_48751523_48751674 0.34 DUT
deoxyuridine triphosphatase
126995
0.05
chrX_11456077_11456228 0.34 ARHGAP6
Rho GTPase activating protein 6
10259
0.3
chr8_118990982_118991133 0.34 EXT1
exostosin glycosyltransferase 1
131596
0.06
chr9_100528747_100528898 0.34 ENSG00000266608
.
66306
0.09
chr5_34598742_34598893 0.34 RAI14
retinoic acid induced 14
57525
0.14
chr14_56381140_56381291 0.34 ENSG00000212522
.
153946
0.04
chr20_36688656_36688807 0.34 ENSG00000252791
.
7583
0.16
chr11_128077291_128077590 0.33 ETS1
v-ets avian erythroblastosis virus E26 oncogene homolog 1
297849
0.01
chr5_64337655_64337871 0.33 ENSG00000207439
.
81433
0.11
chr7_32201662_32201813 0.33 PDE1C
phosphodiesterase 1C, calmodulin-dependent 70kDa
90689
0.1
chr8_8153749_8153900 0.33 ALG1L13P
asparagine-linked glycosylation 1-like 13, pseudogene
54891
0.11
chr7_127410750_127410901 0.33 SND1
staphylococcal nuclease and tudor domain containing 1
117140
0.05
chr13_60713678_60713829 0.33 DIAPH3-AS2
DIAPH3 antisense RNA 2
5079
0.24
chr13_49672995_49673224 0.33 ENSG00000199788
.
3582
0.27
chr1_201423553_201423704 0.33 PHLDA3
pleckstrin homology-like domain, family A, member 3
14684
0.15
chr2_20793453_20793604 0.33 HS1BP3-IT1
HS1BP3 intronic transcript 1 (non-protein coding)
1220
0.52
chr7_143190324_143190475 0.33 TAS2R41
taste receptor, type 2, member 41
15433
0.16
chr11_33713061_33713264 0.33 RP4-541C22.5

5085
0.19
chr8_89130096_89130247 0.33 CTB-118P15.2

143778
0.05
chr10_33631255_33631406 0.33 NRP1
neuropilin 1
6140
0.29
chr10_35620918_35621160 0.33 RP11-324I22.4

4290
0.22
chr4_95330317_95330468 0.33 PDLIM5
PDZ and LIM domain 5
42645
0.19
chr2_175659979_175660130 0.33 CHRNA1
cholinergic receptor, nicotinic, alpha 1 (muscle)
30854
0.19
chr4_157897574_157897725 0.33 PDGFC
platelet derived growth factor C
5103
0.24
chr13_42423265_42423416 0.33 ENSG00000241406
.
41527
0.17
chr16_65347210_65347398 0.33 CDH11
cadherin 11, type 2, OB-cadherin (osteoblast)
191036
0.03
chrY_28466108_28466259 0.32 ENSG00000252948
.
40953
0.2
chr5_10453332_10453562 0.32 ROPN1L
rhophilin associated tail protein 1-like
11459
0.14
chr16_73102131_73102454 0.32 ZFHX3
zinc finger homeobox 3
8695
0.24
chr19_3374038_3374830 0.32 NFIC
nuclear factor I/C (CCAAT-binding transcription factor)
7850
0.19
chr18_25763676_25763827 0.32 CDH2
cadherin 2, type 1, N-cadherin (neuronal)
6341
0.35
chr6_11188200_11188351 0.32 RP3-510L9.1

14590
0.2
chr16_53728728_53728879 0.32 RPGRIP1L
RPGRIP1-like
8919
0.23
chr5_14191108_14191422 0.32 TRIO
trio Rho guanine nucleotide exchange factor
7358
0.33
chr3_159444348_159444499 0.32 IQCJ-SCHIP1
IQCJ-SCHIP1 readthrough
37079
0.16
chr9_89021972_89022123 0.32 ENSG00000222293
.
15996
0.24
chr20_43683503_43683886 0.32 KCNS1
potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1
46056
0.1
chr16_49677699_49678055 0.32 ZNF423
zinc finger protein 423
3114
0.33
chr3_123588793_123588944 0.32 MYLK
myosin light chain kinase
14281
0.22
chr2_236342022_236342173 0.32 AGAP1
ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
60636
0.13
chr2_74373621_74374624 0.32 BOLA3
bolA family member 3
910
0.35
chr11_12191424_12191575 0.32 MICAL2
microtubule associated monooxygenase, calponin and LIM domain containing 2
7796
0.27
chr7_41950835_41950986 0.32 AC005027.3

205977
0.03
chr6_160457258_160457573 0.32 AIRN
antisense of IGF2R non-protein coding RNA
28719
0.19
chr1_52434488_52434639 0.32 ENSG00000200839
.
4519
0.15
chr7_94050761_94050912 0.32 COL1A2
collagen, type I, alpha 2
26963
0.22
chr5_88027740_88027966 0.32 CTC-467M3.2

39385
0.16
chr1_18201641_18201961 0.32 ACTL8
actin-like 8
119993
0.06
chr10_33274428_33274757 0.31 ITGB1
integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
6799
0.27
chr3_78968042_78968193 0.31 ENSG00000240964
.
19325
0.28
chr19_1168901_1169806 0.31 SBNO2
strawberry notch homolog 2 (Drosophila)
411
0.76
chr21_30143536_30143687 0.31 ENSG00000251894
.
28081
0.23
chr4_150085945_150086096 0.31 ENSG00000239168
.
173235
0.04
chr8_32201421_32201572 0.31 ENSG00000200246
.
87484
0.09
chr12_47629984_47630533 0.31 PCED1B
PC-esterase domain containing 1B
12930
0.21
chr2_110756993_110757205 0.31 ENSG00000265682
.
70520
0.1
chr3_187453619_187453770 0.31 BCL6
B-cell CLL/lymphoma 6
663
0.73
chr2_113075036_113075187 0.31 ZC3H6
zinc finger CCCH-type containing 6
41933
0.14
chr16_72289972_72290233 0.31 PMFBP1
polyamine modulated factor 1 binding protein 1
79325
0.09
chr1_225836875_225837026 0.31 ENAH
enabled homolog (Drosophila)
3468
0.27
chr1_46379565_46379716 0.31 MAST2
microtubule associated serine/threonine kinase 2
380
0.91
chr4_174267247_174267398 0.31 HMGB2
high mobility group box 2
11046
0.13
chrY_27544696_27544847 0.31 ENSG00000272042
.
60283
0.14
chr5_95571294_95571445 0.31 ENSG00000206997
.
25438
0.24
chr11_34324437_34324812 0.31 ABTB2
ankyrin repeat and BTB (POZ) domain containing 2
54178
0.15
chr7_90012529_90012680 0.31 CLDN12
claudin 12
431
0.85
chr6_74783073_74783224 0.31 RP11-553A21.3

377294
0.01
chr12_2723257_2723602 0.31 CACNA1C-AS3
CACNA1C antisense RNA 3
6823
0.24
chr15_99440684_99440835 0.31 RP11-654A16.1

3995
0.25
chr16_87120081_87120232 0.31 RP11-899L11.3

129365
0.05
chr13_102263996_102264147 0.31 ITGBL1
integrin, beta-like 1 (with EGF-like repeat domains)
13576
0.3

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of RORA

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.1 0.5 GO:0043589 skin morphogenesis(GO:0043589)
0.1 0.3 GO:0048143 astrocyte activation(GO:0048143)
0.1 0.2 GO:0022605 oogenesis stage(GO:0022605)
0.1 0.2 GO:0006562 proline catabolic process(GO:0006562)
0.1 0.2 GO:0051497 negative regulation of stress fiber assembly(GO:0051497)
0.1 0.2 GO:0001778 plasma membrane repair(GO:0001778)
0.1 0.2 GO:0060754 mast cell chemotaxis(GO:0002551) regulation of mast cell chemotaxis(GO:0060753) positive regulation of mast cell chemotaxis(GO:0060754) mast cell migration(GO:0097531)
0.1 0.1 GO:0001543 ovarian follicle rupture(GO:0001543)
0.1 0.3 GO:0097061 dendritic spine morphogenesis(GO:0060997) regulation of dendritic spine morphogenesis(GO:0061001) dendritic spine organization(GO:0097061)
0.1 0.2 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.1 0.2 GO:0006663 platelet activating factor biosynthetic process(GO:0006663)
0.1 0.2 GO:0060242 contact inhibition(GO:0060242)
0.1 0.2 GO:0001743 optic placode formation(GO:0001743)
0.0 0.2 GO:0060013 righting reflex(GO:0060013)
0.0 0.2 GO:0006020 inositol metabolic process(GO:0006020)
0.0 0.1 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.0 0.1 GO:0010766 negative regulation of sodium ion transport(GO:0010766)
0.0 0.2 GO:0051124 synaptic growth at neuromuscular junction(GO:0051124)
0.0 0.2 GO:0070141 response to UV-A(GO:0070141)
0.0 0.1 GO:0048003 antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003)
0.0 0.2 GO:0048149 behavioral response to ethanol(GO:0048149)
0.0 0.1 GO:2000114 regulation of establishment of cell polarity(GO:2000114)
0.0 0.1 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 0.3 GO:0010896 regulation of triglyceride catabolic process(GO:0010896)
0.0 0.2 GO:0048625 myoblast fate commitment(GO:0048625)
0.0 0.2 GO:0009169 purine nucleoside monophosphate catabolic process(GO:0009128) ribonucleoside monophosphate catabolic process(GO:0009158) purine ribonucleoside monophosphate catabolic process(GO:0009169)
0.0 0.0 GO:0043117 positive regulation of vascular permeability(GO:0043117)
0.0 0.2 GO:0008218 bioluminescence(GO:0008218)
0.0 0.1 GO:0001973 adenosine receptor signaling pathway(GO:0001973) G-protein coupled purinergic receptor signaling pathway(GO:0035588)
0.0 0.1 GO:0071436 sodium ion export(GO:0071436)
0.0 0.1 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.0 0.1 GO:0044413 evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.0 0.1 GO:0009414 response to water deprivation(GO:0009414)
0.0 0.2 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0 0.1 GO:0035385 Roundabout signaling pathway(GO:0035385)
0.0 0.1 GO:0002689 negative regulation of leukocyte chemotaxis(GO:0002689)
0.0 0.2 GO:0001514 selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.0 0.1 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
0.0 0.3 GO:0048207 vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208) COPII-coated vesicle budding(GO:0090114)
0.0 0.1 GO:0051182 coenzyme transport(GO:0051182)
0.0 0.2 GO:0002281 macrophage activation involved in immune response(GO:0002281)
0.0 0.1 GO:0046113 nucleobase catabolic process(GO:0046113)
0.0 0.1 GO:0046952 ketone body catabolic process(GO:0046952)
0.0 0.1 GO:0035511 oxidative DNA demethylation(GO:0035511)
0.0 0.1 GO:0010193 response to ozone(GO:0010193)
0.0 0.1 GO:0050774 negative regulation of dendrite morphogenesis(GO:0050774)
0.0 0.1 GO:0051088 PMA-inducible membrane protein ectodomain proteolysis(GO:0051088)
0.0 0.0 GO:0098870 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0 0.1 GO:0006102 isocitrate metabolic process(GO:0006102)
0.0 0.1 GO:0031065 positive regulation of histone deacetylation(GO:0031065)
0.0 0.1 GO:0055098 response to low-density lipoprotein particle(GO:0055098)
0.0 0.3 GO:0033631 cell-cell adhesion mediated by integrin(GO:0033631)
0.0 0.2 GO:0045075 interleukin-12 biosynthetic process(GO:0042090) regulation of interleukin-12 biosynthetic process(GO:0045075)
0.0 0.1 GO:0014874 response to stimulus involved in regulation of muscle adaptation(GO:0014874)
0.0 0.2 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
0.0 0.1 GO:0060676 ureteric bud formation(GO:0060676)
0.0 0.1 GO:0071694 sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.0 0.1 GO:0046121 deoxyribonucleoside catabolic process(GO:0046121)
0.0 0.1 GO:0018242 protein O-linked glycosylation via serine(GO:0018242) protein O-linked glycosylation via threonine(GO:0018243)
0.0 0.0 GO:0010715 regulation of extracellular matrix disassembly(GO:0010715) negative regulation of extracellular matrix disassembly(GO:0010716) regulation of extracellular matrix organization(GO:1903053) negative regulation of extracellular matrix organization(GO:1903054)
0.0 0.1 GO:0060083 smooth muscle contraction involved in micturition(GO:0060083)
0.0 0.2 GO:0042640 anagen(GO:0042640)
0.0 0.1 GO:0032988 ribonucleoprotein complex disassembly(GO:0032988)
0.0 0.1 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 0.1 GO:0034651 cortisol metabolic process(GO:0034650) cortisol biosynthetic process(GO:0034651)
0.0 0.1 GO:0046628 positive regulation of insulin receptor signaling pathway(GO:0046628) positive regulation of cellular response to insulin stimulus(GO:1900078)
0.0 0.0 GO:0009151 purine deoxyribonucleotide metabolic process(GO:0009151)
0.0 0.3 GO:0035329 hippo signaling(GO:0035329)
0.0 0.1 GO:0002903 negative regulation of B cell apoptotic process(GO:0002903)
0.0 0.1 GO:0015705 iodide transport(GO:0015705)
0.0 0.1 GO:0006391 transcription initiation from mitochondrial promoter(GO:0006391)
0.0 0.1 GO:0034393 positive regulation of muscle cell apoptotic process(GO:0010661) positive regulation of smooth muscle cell apoptotic process(GO:0034393)
0.0 0.1 GO:0001946 lymphangiogenesis(GO:0001946) lymph vessel morphogenesis(GO:0036303)
0.0 0.1 GO:0006533 aspartate metabolic process(GO:0006531) aspartate catabolic process(GO:0006533)
0.0 0.1 GO:0048755 branching morphogenesis of a nerve(GO:0048755)
0.0 0.0 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.0 0.1 GO:0007144 female meiosis I(GO:0007144)
0.0 0.1 GO:0060009 Sertoli cell development(GO:0060009)
0.0 0.0 GO:0060174 limb bud formation(GO:0060174)
0.0 0.2 GO:0001542 ovulation from ovarian follicle(GO:0001542)
0.0 0.1 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.0 0.0 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.0 0.0 GO:0060594 mammary gland specification(GO:0060594)
0.0 0.1 GO:0006930 substrate-dependent cell migration, cell extension(GO:0006930)
0.0 0.1 GO:0045627 positive regulation of T-helper 1 cell differentiation(GO:0045627)
0.0 0.1 GO:0046520 sphingoid biosynthetic process(GO:0046520)
0.0 0.0 GO:0046049 UMP biosynthetic process(GO:0006222) pyrimidine ribonucleoside monophosphate metabolic process(GO:0009173) pyrimidine ribonucleoside monophosphate biosynthetic process(GO:0009174) UMP metabolic process(GO:0046049)
0.0 0.1 GO:0006927 obsolete transformed cell apoptotic process(GO:0006927)
0.0 0.0 GO:0043374 CD8-positive, alpha-beta T cell activation(GO:0036037) CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0 0.1 GO:0072386 plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.0 0.1 GO:0070050 neuron cellular homeostasis(GO:0070050)
0.0 0.1 GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0 0.1 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.0 0.1 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
0.0 0.0 GO:0046882 negative regulation of follicle-stimulating hormone secretion(GO:0046882)
0.0 0.0 GO:0032413 negative regulation of ion transmembrane transporter activity(GO:0032413)
0.0 0.1 GO:0005981 regulation of glycogen catabolic process(GO:0005981)
0.0 0.1 GO:0003091 renal water homeostasis(GO:0003091)
0.0 0.0 GO:0061525 hindgut morphogenesis(GO:0007442) hindgut development(GO:0061525)
0.0 0.1 GO:0046426 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0 0.1 GO:0016241 regulation of macroautophagy(GO:0016241)
0.0 0.0 GO:0072217 negative regulation of metanephros development(GO:0072217)
0.0 0.1 GO:0006295 nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295)
0.0 0.1 GO:0006527 arginine catabolic process(GO:0006527)
0.0 0.3 GO:0042474 middle ear morphogenesis(GO:0042474)
0.0 0.3 GO:0010171 body morphogenesis(GO:0010171)
0.0 0.1 GO:1903301 regulation of glucokinase activity(GO:0033131) positive regulation of glucokinase activity(GO:0033133) regulation of hexokinase activity(GO:1903299) positive regulation of hexokinase activity(GO:1903301)
0.0 0.1 GO:0002667 lymphocyte anergy(GO:0002249) regulation of T cell anergy(GO:0002667) positive regulation of T cell anergy(GO:0002669) T cell anergy(GO:0002870) regulation of lymphocyte anergy(GO:0002911) positive regulation of lymphocyte anergy(GO:0002913)
0.0 0.1 GO:0014912 negative regulation of smooth muscle cell migration(GO:0014912)
0.0 0.1 GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.0 0.1 GO:0021670 lateral ventricle development(GO:0021670)
0.0 0.0 GO:0072007 mesangial cell differentiation(GO:0072007) kidney interstitial fibroblast differentiation(GO:0072071) renal interstitial fibroblast development(GO:0072141) mesangial cell development(GO:0072143) pericyte cell differentiation(GO:1904238)
0.0 0.1 GO:0043461 proton-transporting ATP synthase complex assembly(GO:0043461) proton-transporting ATP synthase complex biogenesis(GO:0070272)
0.0 0.1 GO:0048840 otolith development(GO:0048840)
0.0 0.0 GO:0001554 luteolysis(GO:0001554)
0.0 0.1 GO:0060638 mesenchymal-epithelial cell signaling(GO:0060638)
0.0 0.1 GO:0031116 positive regulation of microtubule polymerization(GO:0031116)
0.0 0.4 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.0 0.0 GO:0097709 connective tissue replacement involved in inflammatory response wound healing(GO:0002248) connective tissue replacement(GO:0097709)
0.0 0.0 GO:0080111 DNA demethylation(GO:0080111)
0.0 0.1 GO:0033600 negative regulation of mammary gland epithelial cell proliferation(GO:0033600)
0.0 0.1 GO:0009756 carbohydrate mediated signaling(GO:0009756)
0.0 0.1 GO:0006678 glucosylceramide metabolic process(GO:0006678)
0.0 0.0 GO:0000212 meiotic spindle organization(GO:0000212)
0.0 0.1 GO:0010966 regulation of phosphate transport(GO:0010966)
0.0 0.1 GO:0008300 isoprenoid catabolic process(GO:0008300)
0.0 0.1 GO:0031529 ruffle organization(GO:0031529)
0.0 0.1 GO:0043497 regulation of protein heterodimerization activity(GO:0043497)
0.0 0.1 GO:0007386 compartment pattern specification(GO:0007386)
0.0 0.1 GO:0070777 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0 0.1 GO:0045077 negative regulation of interferon-gamma biosynthetic process(GO:0045077)
0.0 0.1 GO:0033173 calcineurin-NFAT signaling cascade(GO:0033173)
0.0 0.3 GO:0008038 neuron recognition(GO:0008038)
0.0 0.1 GO:0070296 sarcoplasmic reticulum calcium ion transport(GO:0070296)
0.0 0.0 GO:0034201 response to oleic acid(GO:0034201)
0.0 0.0 GO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.0 0.2 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
0.0 0.0 GO:0070634 transepithelial ammonium transport(GO:0070634)
0.0 0.1 GO:0009650 UV protection(GO:0009650)
0.0 0.1 GO:0009649 entrainment of circadian clock(GO:0009649)
0.0 0.0 GO:0006177 GMP biosynthetic process(GO:0006177)
0.0 0.1 GO:0016246 RNA interference(GO:0016246)
0.0 0.1 GO:0001885 endothelial cell development(GO:0001885)
0.0 0.0 GO:0048368 lateral mesoderm development(GO:0048368)
0.0 0.1 GO:0007258 JUN phosphorylation(GO:0007258)
0.0 0.4 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.0 0.1 GO:0031639 plasminogen activation(GO:0031639)
0.0 0.1 GO:0071549 cellular response to dexamethasone stimulus(GO:0071549)
0.0 0.0 GO:0060059 embryonic retina morphogenesis in camera-type eye(GO:0060059)
0.0 0.1 GO:0043383 negative T cell selection(GO:0043383)
0.0 0.1 GO:0060259 regulation of feeding behavior(GO:0060259)
0.0 0.0 GO:0006931 substrate-dependent cell migration, cell attachment to substrate(GO:0006931)
0.0 0.1 GO:0060708 spongiotrophoblast differentiation(GO:0060708)
0.0 0.1 GO:0021513 spinal cord dorsal/ventral patterning(GO:0021513)
0.0 0.1 GO:0042693 muscle cell fate commitment(GO:0042693)
0.0 0.1 GO:0048702 embryonic neurocranium morphogenesis(GO:0048702)
0.0 0.1 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
0.0 0.0 GO:0046813 receptor-mediated virion attachment to host cell(GO:0046813)
0.0 0.1 GO:0035414 negative regulation of catenin import into nucleus(GO:0035414)
0.0 0.0 GO:0003323 type B pancreatic cell development(GO:0003323)
0.0 0.0 GO:0045601 regulation of endothelial cell differentiation(GO:0045601)
0.0 0.0 GO:0051590 positive regulation of neurotransmitter transport(GO:0051590)
0.0 0.0 GO:0048861 leukemia inhibitory factor signaling pathway(GO:0048861)
0.0 0.1 GO:0009200 deoxyribonucleoside triphosphate metabolic process(GO:0009200)
0.0 0.0 GO:0042501 serine phosphorylation of STAT protein(GO:0042501)
0.0 0.0 GO:0002238 response to molecule of fungal origin(GO:0002238)
0.0 0.0 GO:0003283 atrial septum development(GO:0003283) atrial septum morphogenesis(GO:0060413)
0.0 0.1 GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518) negative regulation of signal transduction by p53 class mediator(GO:1901797)
0.0 0.0 GO:0048319 axial mesoderm morphogenesis(GO:0048319)
0.0 0.1 GO:0042415 norepinephrine metabolic process(GO:0042415)
0.0 0.0 GO:0021798 forebrain dorsal/ventral pattern formation(GO:0021798)
0.0 0.0 GO:0045002 DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792) double-strand break repair via single-strand annealing(GO:0045002)
0.0 0.1 GO:0031641 regulation of myelination(GO:0031641)
0.0 0.0 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.0 0.1 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
0.0 0.1 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.0 0.0 GO:0010447 response to acidic pH(GO:0010447)
0.0 0.1 GO:0050919 negative chemotaxis(GO:0050919)
0.0 0.1 GO:0006498 N-terminal protein lipidation(GO:0006498)
0.0 0.1 GO:0032075 positive regulation of nuclease activity(GO:0032075)
0.0 0.1 GO:0050917 sensory perception of umami taste(GO:0050917)
0.0 0.2 GO:0007029 endoplasmic reticulum organization(GO:0007029)
0.0 0.0 GO:0071480 cellular response to gamma radiation(GO:0071480)
0.0 0.0 GO:0051307 resolution of meiotic recombination intermediates(GO:0000712) meiotic chromosome separation(GO:0051307)
0.0 0.0 GO:0060605 tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662)
0.0 0.0 GO:0072216 positive regulation of metanephros development(GO:0072216)
0.0 0.0 GO:0001945 lymph vessel development(GO:0001945)
0.0 0.1 GO:0009396 folic acid-containing compound biosynthetic process(GO:0009396)
0.0 0.2 GO:0060415 muscle tissue morphogenesis(GO:0060415)
0.0 0.1 GO:0007567 parturition(GO:0007567)
0.0 0.0 GO:0022617 extracellular matrix disassembly(GO:0022617)
0.0 0.0 GO:0019856 'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) pyrimidine nucleobase biosynthetic process(GO:0019856)
0.0 0.0 GO:0071028 RNA surveillance(GO:0071025) nuclear RNA surveillance(GO:0071027) nuclear mRNA surveillance(GO:0071028)
0.0 0.0 GO:0036072 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.0 0.1 GO:0006707 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.0 0.1 GO:0071044 histone mRNA catabolic process(GO:0071044)
0.0 0.1 GO:1901796 regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043516) regulation of signal transduction by p53 class mediator(GO:1901796)
0.0 0.0 GO:0002023 reduction of food intake in response to dietary excess(GO:0002023)
0.0 0.2 GO:0050819 negative regulation of coagulation(GO:0050819)
0.0 0.0 GO:0070307 lens fiber cell development(GO:0070307)
0.0 0.1 GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771)
0.0 0.0 GO:0002246 wound healing involved in inflammatory response(GO:0002246) smooth muscle adaptation(GO:0014805) inflammatory response to wounding(GO:0090594)
0.0 0.0 GO:0002858 natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002420) natural killer cell mediated immune response to tumor cell(GO:0002423) regulation of natural killer cell mediated immune response to tumor cell(GO:0002855) positive regulation of natural killer cell mediated immune response to tumor cell(GO:0002857) regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002858) positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002860)
0.0 0.0 GO:0010225 response to UV-C(GO:0010225)
0.0 0.0 GO:0071034 CUT catabolic process(GO:0071034) CUT metabolic process(GO:0071043)
0.0 0.0 GO:0031536 positive regulation of exit from mitosis(GO:0031536)
0.0 0.0 GO:0045046 protein import into peroxisome membrane(GO:0045046)
0.0 0.0 GO:0060426 lung vasculature development(GO:0060426)
0.0 0.0 GO:0051305 chromosome movement towards spindle pole(GO:0051305)
0.0 0.1 GO:0045008 depyrimidination(GO:0045008)
0.0 0.0 GO:0001976 neurological system process involved in regulation of systemic arterial blood pressure(GO:0001976)
0.0 0.1 GO:0010633 negative regulation of epithelial cell migration(GO:0010633)
0.0 0.0 GO:0045056 transcytosis(GO:0045056)
0.0 0.1 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.0 0.0 GO:0007500 mesodermal cell fate determination(GO:0007500)
0.0 0.0 GO:0000491 small nucleolar ribonucleoprotein complex assembly(GO:0000491) box C/D snoRNP assembly(GO:0000492)
0.0 0.0 GO:0007008 outer mitochondrial membrane organization(GO:0007008) protein import into mitochondrial outer membrane(GO:0045040)
0.0 0.1 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.0 0.0 GO:0006435 threonyl-tRNA aminoacylation(GO:0006435)
0.0 0.0 GO:0033505 floor plate morphogenesis(GO:0033505)
0.0 0.1 GO:0018345 protein palmitoylation(GO:0018345)
0.0 0.0 GO:0043312 neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312)
0.0 0.0 GO:0019511 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) 4-hydroxyproline metabolic process(GO:0019471) peptidyl-proline hydroxylation(GO:0019511)
0.0 0.1 GO:0006264 mitochondrial DNA replication(GO:0006264)
0.0 0.0 GO:0030728 ovulation(GO:0030728)
0.0 0.0 GO:0007598 blood coagulation, extrinsic pathway(GO:0007598)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.1 GO:0071664 catenin-TCF7L2 complex(GO:0071664)
0.1 0.2 GO:0030934 anchoring collagen complex(GO:0030934)
0.1 0.5 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.4 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.5 GO:0098878 ionotropic glutamate receptor complex(GO:0008328) neurotransmitter receptor complex(GO:0098878)
0.0 0.2 GO:0071437 invadopodium(GO:0071437)
0.0 0.2 GO:0098645 network-forming collagen trimer(GO:0098642) collagen network(GO:0098645)
0.0 0.1 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0 0.1 GO:0032449 CBM complex(GO:0032449)
0.0 0.2 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 0.1 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
0.0 0.0 GO:0098651 basement membrane collagen trimer(GO:0098651)
0.0 0.3 GO:0014704 intercalated disc(GO:0014704) cell-cell contact zone(GO:0044291)
0.0 0.1 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.0 0.2 GO:0005606 laminin-1 complex(GO:0005606)
0.0 0.6 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 0.1 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.0 0.1 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.2 GO:0030122 AP-2 adaptor complex(GO:0030122) clathrin coat of endocytic vesicle(GO:0030128)
0.0 0.1 GO:0017059 palmitoyltransferase complex(GO:0002178) serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0 0.1 GO:0036454 insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454)
0.0 0.0 GO:0005899 insulin receptor complex(GO:0005899)
0.0 0.5 GO:0005581 collagen trimer(GO:0005581)
0.0 0.2 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0 0.3 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 0.1 GO:0001940 male pronucleus(GO:0001940)
0.0 0.0 GO:0060200 clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201)
0.0 0.3 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 0.1 GO:0045298 tubulin complex(GO:0045298)
0.0 0.1 GO:0005861 troponin complex(GO:0005861)
0.0 0.2 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 0.1 GO:0033018 sarcoplasmic reticulum lumen(GO:0033018)
0.0 0.1 GO:0071256 Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.0 1.3 GO:0070160 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.0 0.3 GO:0005811 lipid particle(GO:0005811)
0.0 0.1 GO:0042587 glycogen granule(GO:0042587)
0.0 0.0 GO:0043083 synaptic cleft(GO:0043083)
0.0 0.1 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.0 0.3 GO:0031594 neuromuscular junction(GO:0031594)
0.0 0.0 GO:0070083 clathrin-sculpted monoamine transport vesicle(GO:0070081) clathrin-sculpted monoamine transport vesicle membrane(GO:0070083)
0.0 0.0 GO:0071062 alphav-beta3 integrin-vitronectin complex(GO:0071062)
0.0 0.0 GO:0031931 TORC1 complex(GO:0031931)
0.0 0.1 GO:0016012 dystroglycan complex(GO:0016011) sarcoglycan complex(GO:0016012)
0.0 0.2 GO:0030134 ER to Golgi transport vesicle(GO:0030134)
0.0 0.1 GO:0030315 T-tubule(GO:0030315)
0.0 0.7 GO:0034707 chloride channel complex(GO:0034707)
0.0 0.1 GO:0031512 motile primary cilium(GO:0031512)
0.0 0.0 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.0 0.7 GO:0030426 growth cone(GO:0030426)
0.0 0.1 GO:0032838 cell projection cytoplasm(GO:0032838)
0.0 0.0 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
0.0 0.0 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.0 0.0 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.0 0.0 GO:0005787 signal peptidase complex(GO:0005787)
0.0 0.1 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 1.0 GO:0005925 focal adhesion(GO:0005925)
0.0 0.1 GO:0032389 MutLalpha complex(GO:0032389)
0.0 0.1 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 0.1 GO:0031527 filopodium membrane(GO:0031527)
0.0 0.0 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.1 GO:0034464 BBSome(GO:0034464)
0.0 0.1 GO:0035253 ciliary rootlet(GO:0035253)
0.0 0.1 GO:0043205 fibril(GO:0043205)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0050508 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.1 0.3 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.1 0.4 GO:0005010 insulin-like growth factor-activated receptor activity(GO:0005010)
0.1 0.2 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.1 0.5 GO:0017154 semaphorin receptor activity(GO:0017154)
0.1 0.2 GO:0015204 urea transmembrane transporter activity(GO:0015204)
0.1 0.1 GO:0045159 myosin II binding(GO:0045159)
0.1 0.2 GO:0070324 thyroid hormone binding(GO:0070324)
0.1 0.4 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.1 0.3 GO:0042153 obsolete RPTP-like protein binding(GO:0042153)
0.1 0.4 GO:0042805 actinin binding(GO:0042805)
0.1 0.2 GO:0004800 thyroxine 5'-deiodinase activity(GO:0004800)
0.0 0.2 GO:0019211 phosphatase activator activity(GO:0019211)
0.0 0.1 GO:0004321 fatty-acyl-CoA synthase activity(GO:0004321)
0.0 0.3 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.0 0.1 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.1 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
0.0 0.2 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.0 0.1 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.0 0.2 GO:0016934 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.0 0.4 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 0.1 GO:0030151 molybdenum ion binding(GO:0030151)
0.0 0.1 GO:0004758 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0 0.2 GO:0043274 phospholipase binding(GO:0043274)
0.0 0.3 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.0 0.1 GO:0035514 DNA demethylase activity(GO:0035514) DNA-N1-methyladenine dioxygenase activity(GO:0043734)
0.0 0.1 GO:0050253 retinyl-palmitate esterase activity(GO:0050253)
0.0 0.1 GO:0003831 beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity(GO:0003831)
0.0 0.1 GO:0003896 DNA primase activity(GO:0003896)
0.0 0.1 GO:0031544 procollagen-proline 3-dioxygenase activity(GO:0019797) peptidyl-proline 3-dioxygenase activity(GO:0031544)
0.0 0.1 GO:0004448 isocitrate dehydrogenase activity(GO:0004448)
0.0 0.3 GO:0004859 phospholipase inhibitor activity(GO:0004859)
0.0 0.1 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.0 0.1 GO:0003680 AT DNA binding(GO:0003680)
0.0 0.0 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.0 0.1 GO:0004985 opioid receptor activity(GO:0004985)
0.0 0.6 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 0.1 GO:0015142 citrate transmembrane transporter activity(GO:0015137) tricarboxylic acid transmembrane transporter activity(GO:0015142)
0.0 0.1 GO:0004117 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117)
0.0 0.1 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.0 0.1 GO:0042608 T cell receptor binding(GO:0042608)
0.0 0.1 GO:0008475 procollagen-lysine 5-dioxygenase activity(GO:0008475)
0.0 0.1 GO:0033765 steroid dehydrogenase activity, acting on the CH-CH group of donors(GO:0033765)
0.0 0.1 GO:0004597 peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.0 0.2 GO:0046965 retinoid X receptor binding(GO:0046965)
0.0 0.1 GO:0004645 phosphorylase activity(GO:0004645)
0.0 0.0 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.0 0.0 GO:0045545 syndecan binding(GO:0045545)
0.0 0.1 GO:0070053 thrombospondin receptor activity(GO:0070053)
0.0 0.1 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.0 0.1 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
0.0 0.1 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.0 0.1 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.0 0.0 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.0 0.1 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0 0.8 GO:0005518 collagen binding(GO:0005518)
0.0 0.0 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017)
0.0 0.1 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 0.1 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.0 0.0 GO:0046975 histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.0 0.2 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029)
0.0 0.1 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0 0.1 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.0 0.1 GO:0003696 satellite DNA binding(GO:0003696)
0.0 0.1 GO:0030284 estrogen receptor activity(GO:0030284)
0.0 0.1 GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517)
0.0 0.2 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641)
0.0 0.2 GO:0071617 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) lysophosphatidic acid acyltransferase activity(GO:0042171) lysophospholipid acyltransferase activity(GO:0071617)
0.0 0.1 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.1 GO:0015166 polyol transmembrane transporter activity(GO:0015166)
0.0 0.1 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0 0.2 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0 0.1 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0 0.1 GO:0033130 acetylcholine receptor binding(GO:0033130)
0.0 0.2 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.1 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.0 0.1 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.0 0.1 GO:0048495 Roundabout binding(GO:0048495)
0.0 0.1 GO:0016421 CoA carboxylase activity(GO:0016421)
0.0 0.0 GO:0050698 proteoglycan sulfotransferase activity(GO:0050698)
0.0 0.0 GO:0016623 oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor(GO:0016623)
0.0 0.0 GO:0070411 I-SMAD binding(GO:0070411)
0.0 0.1 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 0.0 GO:0050265 RNA uridylyltransferase activity(GO:0050265)
0.0 0.0 GO:0005534 galactose binding(GO:0005534)
0.0 0.1 GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.0 0.1 GO:0005143 interleukin-12 receptor binding(GO:0005143)
0.0 0.1 GO:0004470 malic enzyme activity(GO:0004470)
0.0 0.1 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.0 0.1 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717)
0.0 0.1 GO:0030172 troponin C binding(GO:0030172)
0.0 0.0 GO:0043008 ATP-dependent protein binding(GO:0043008)
0.0 0.1 GO:0016411 acylglycerol O-acyltransferase activity(GO:0016411)
0.0 0.0 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)
0.0 0.0 GO:0003945 N-acetyllactosamine synthase activity(GO:0003945)
0.0 0.0 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.1 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.0 0.1 GO:0034235 GPI anchor binding(GO:0034235)
0.0 0.1 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 0.1 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 0.1 GO:0030955 potassium ion binding(GO:0030955)
0.0 0.0 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
0.0 0.0 GO:0070569 uridylyltransferase activity(GO:0070569)
0.0 0.1 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.0 0.0 GO:0050897 cobalt ion binding(GO:0050897)
0.0 0.0 GO:0061505 DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.0 0.0 GO:0016151 nickel cation binding(GO:0016151)
0.0 0.0 GO:0031127 galactoside 2-alpha-L-fucosyltransferase activity(GO:0008107) alpha-(1,2)-fucosyltransferase activity(GO:0031127)
0.0 0.0 GO:0004924 oncostatin-M receptor activity(GO:0004924)
0.0 0.0 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.0 0.2 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 0.1 GO:0030250 cyclase activator activity(GO:0010853) guanylate cyclase activator activity(GO:0030250)
0.0 0.1 GO:0042605 peptide antigen binding(GO:0042605)
0.0 0.1 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
0.0 0.0 GO:0004948 calcitonin receptor activity(GO:0004948)
0.0 0.2 GO:0008200 ion channel inhibitor activity(GO:0008200)
0.0 0.1 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.2 GO:0004675 transmembrane receptor protein serine/threonine kinase activity(GO:0004675)
0.0 0.1 GO:0070063 RNA polymerase binding(GO:0070063)
0.0 0.0 GO:0004829 threonine-tRNA ligase activity(GO:0004829)
0.0 0.1 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.0 0.0 GO:0042285 UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285)
0.0 0.1 GO:0034483 heparan sulfate sulfotransferase activity(GO:0034483)
0.0 0.1 GO:0008409 5'-3' exonuclease activity(GO:0008409)
0.0 0.1 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.1 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.0 0.1 GO:0031369 translation initiation factor binding(GO:0031369)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.0 0.1 PID TXA2PATHWAY Thromboxane A2 receptor signaling
0.0 0.1 PID AVB3 OPN PATHWAY Osteopontin-mediated events
0.0 1.2 NABA COLLAGENS Genes encoding collagen proteins
0.0 0.1 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.0 0.0 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.0 0.3 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.0 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.0 0.3 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions
0.0 0.4 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 0.0 ST ADRENERGIC Adrenergic Pathway
0.0 0.1 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.0 0.0 PID GLYPICAN 1PATHWAY Glypican 1 network
0.0 0.1 PID S1P S1P1 PATHWAY S1P1 pathway
0.0 0.2 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 0.3 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.1 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 0.2 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 0.1 PID INTEGRIN1 PATHWAY Beta1 integrin cell surface interactions
0.0 0.4 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 0.3 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.3 PID EPHB FWD PATHWAY EPHB forward signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.1 REACTOME PLC BETA MEDIATED EVENTS Genes involved in PLC beta mediated events
0.1 0.7 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.1 REACTOME SOS MEDIATED SIGNALLING Genes involved in SOS-mediated signalling
0.0 0.4 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
0.0 0.4 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.0 0.0 REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.0 0.4 REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.0 0.8 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.0 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.0 1.4 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.5 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 0.5 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.3 REACTOME ACYL CHAIN REMODELLING OF PS Genes involved in Acyl chain remodelling of PS
0.0 0.6 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 0.4 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 0.1 REACTOME FRS2 MEDIATED CASCADE Genes involved in FRS2-mediated cascade
0.0 0.0 REACTOME BILE ACID AND BILE SALT METABOLISM Genes involved in Bile acid and bile salt metabolism
0.0 0.3 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.2 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.0 0.2 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.0 0.2 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.2 REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY Genes involved in Adenylate cyclase inhibitory pathway
0.0 0.4 REACTOME CELL CELL JUNCTION ORGANIZATION Genes involved in Cell-cell junction organization
0.0 0.0 REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.0 0.1 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0 0.1 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.0 0.1 REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.0 0.2 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.0 REACTOME SIGNALING BY FGFR3 MUTANTS Genes involved in Signaling by FGFR3 mutants
0.0 0.0 REACTOME HYALURONAN METABOLISM Genes involved in Hyaluronan metabolism
0.0 0.1 REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES Genes involved in p75NTR recruits signalling complexes
0.0 0.3 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 0.2 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 0.1 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi