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ENCODE: H3K4me1 ChIP-Seq of primary human cells
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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for RORC

Z-value: 1.34

Motif logo

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Transcription factors associated with RORC

Gene Symbol Gene ID Gene Info
RORC
ENSG00000143365.12 RORC

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
RORCchr1_151805393_15180554411200.2685630.694.1e-02Click!
RORCchr1_151790791_15179094277010.075481-0.551.3e-01Click!
RORCchr1_151804360_151804511870.9242520.531.4e-01Click!
RORCchr1_151804778_1518049295050.5825310.511.6e-01Click!
RORCchr1_151791815_15179196666770.0778290.501.7e-01Click!

Activity of the RORC motif across conditions

Conditions sorted by the z-value of the RORC motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr16_28323403_28323591 0.73 SBK1
 SH3 domain binding kinase 1
 19657
 0.17
chr9_120309696_120309847 0.67 ASTN2
 astrotactin 2
 132423
 0.05
chr20_39790564_39790833 0.67 RP1-1J6.2
24055
 0.17
chr15_60848077_60848282 0.55 CTD-2501E16.2
26007
 0.16
chrX_39170131_39170563 0.52 ENSG00000207122
 .
 229809
 0.02
chr3_16419122_16419438 0.51 RP11-415F23.4
32647
 0.16
chr2_162872036_162872217 0.51 AC008063.2
57640
 0.12
chr15_60864333_60864586 0.48 RORA
 RAR-related orphan receptor A
 20281
 0.19
chr2_101244357_101244508 0.47 ENSG00000265839
 .
 27104
 0.17
chr2_30556414_30556569 0.47 ENSG00000221377
 .
 98823
 0.07
chrX_107261303_107261483 0.47 VSIG1
 V-set and immunoglobulin domain containing 1
 26807
 0.16
chr10_135288751_135288902 0.45 ENSG00000266547
 .
 22314
 0.12
chr3_33095020_33095171 0.45 GLB1
 galactosidase, beta 1
 43189
 0.12
chr2_30538467_30538753 0.45 LBH
 limb bud and heart development
 83564
 0.09
chr5_64423288_64423439 0.44 ENSG00000207439
 .
 4167
 0.36
chr6_16481204_16481503 0.44 ENSG00000265642
 .
 52599
 0.17
chr3_113949300_113949543 0.43 ZNF80
 zinc finger protein 80
 7004
 0.18
chr14_56274665_56274816 0.43 KTN1
 kinectin 1 (kinesin receptor)
 135092
 0.05
chr2_112291387_112291942 0.43 ENSG00000266139
 .
 212996
 0.02
chr8_128189680_128189831 0.42 POU5F1B
 POU class 5 homeobox 1B
 236780
 0.02
chr15_38828419_38828665 0.42 ENSG00000201509
 .
 5902
 0.18
chr9_123665604_123665920 0.42 TRAF1
 TNF receptor-associated factor 1
 11088
 0.19
chr10_128087058_128087209 0.41 ADAM12
 ADAM metallopeptidase domain 12
 10109
 0.27
chr3_176844863_176845014 0.41 ENSG00000200882
 .
 1030
 0.58
chr2_87551340_87551620 0.40 IGKV3OR2-268
 immunoglobulin kappa variable 3/OR2-268 (non-functional)
 14154
 0.29
chr16_69287722_69287994 0.37 RP11-70O5.2
13406
 0.13
chr16_58653793_58653944 0.36 ENSG00000239121
 .
 1289
 0.4
chr8_41334953_41335104 0.36 GOLGA7
 golgin A7
 12887
 0.18
chr10_92404426_92404577 0.35 HTR7
 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled
 212954
 0.02
chr17_2613496_2614321 0.35 CLUH
 clustered mitochondria (cluA/CLU1) homolog
 584
 0.59
chr9_127911887_127912038 0.34 SCAI
 suppressor of cancer cell invasion
 6187
 0.21
chr13_44771875_44772026 0.34 SMIM2
 small integral membrane protein 2
 36557
 0.17
chr1_167474737_167474944 0.34 CD247
 CD247 molecule
 12935
 0.2
chr6_142889602_142889753 0.34 GPR126
 G protein-coupled receptor 126
 178228
 0.03
chr3_133179879_133180030 0.33 BFSP2-AS1
 BFSP2 antisense RNA 1
 5334
 0.26
chr12_92396000_92396151 0.32 C12orf79
 chromosome 12 open reading frame 79
 134722
 0.05
chr17_47872778_47872961 0.32 KAT7
 K(lysine) acetyltransferase 7
 5854
 0.16
chr4_15162709_15162860 0.31 RP11-665G4.1
66800
 0.12
chr12_9839275_9839504 0.31 CLEC2D
 C-type lectin domain family 2, member D
 1108
 0.41
chr2_175659979_175660130 0.31 CHRNA1
 cholinergic receptor, nicotinic, alpha 1 (muscle)
 30854
 0.19
chr8_27523533_27523684 0.30 ENSG00000222862
 .
 13741
 0.15
chr1_67637711_67637872 0.30 IL23R
 interleukin 23 receptor
 5622
 0.19
chr1_40024425_40024576 0.30 PABPC4
 poly(A) binding protein, cytoplasmic 4 (inducible form)
 3360
 0.16
chr22_45459666_45459817 0.30 PHF21B
 PHD finger protein 21B
 53861
 0.12
chr2_39798480_39798631 0.30 AC007246.3
52739
 0.15
chr3_10594411_10594577 0.29 ATP2B2-IT1
 ATP2B2 intronic transcript 1 (non-protein coding)
 17565
 0.19
chr1_2573387_2574075 0.29 MMEL1
 membrane metallo-endopeptidase-like 1
 9250
 0.15
chr13_40779053_40779204 0.29 ENSG00000207458
 .
 21836
 0.28
chr13_80065630_80065781 0.29 NDFIP2
 Nedd4 family interacting protein 2
 10117
 0.21
chr9_134536993_134537144 0.29 RAPGEF1
 Rap guanine nucleotide exchange factor (GEF) 1
 35733
 0.17
chr12_68050178_68050329 0.29 DYRK2
 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
 5004
 0.28
chr17_64669838_64669989 0.29 AC006947.1
2577
 0.3
chr3_46022771_46022930 0.28 FYCO1
 FYVE and coiled-coil domain containing 1
 3637
 0.22
chr5_61639146_61639342 0.28 KIF2A
 kinesin heavy chain member 2A
 17889
 0.22
chr10_17702403_17702554 0.28 STAM
 signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
 16214
 0.14
chr1_212498504_212498655 0.28 RP11-384C4.7
6476
 0.15
chr14_64883279_64883430 0.28 CTD-2555O16.4
25602
 0.12
chr1_205774264_205775306 0.28 SLC41A1
 solute carrier family 41 (magnesium transporter), member 1
 7519
 0.17
chr17_48964494_48964676 0.28 TOB1
 transducer of ERBB2, 1
 19246
 0.15
chr15_69486667_69486818 0.27 ENSG00000266374
 .
 33752
 0.13
chr8_123803486_123803637 0.27 ZHX2
 zinc fingers and homeoboxes 2
 9928
 0.21
chr17_74674953_74675104 0.27 RP11-318A15.2
7004
 0.09
chr1_204652946_204653097 0.27 LRRN2
 leucine rich repeat neuronal 2
 1460
 0.37
chr4_39720673_39720847 0.27 ENSG00000252975
 .
 8964
 0.18
chr12_78683178_78683329 0.27 NAV3
 neuron navigator 3
 90397
 0.1
chr21_32537346_32537497 0.27 TIAM1
 T-cell lymphoma invasion and metastasis 1
 34882
 0.22
chr16_87490684_87490835 0.27 ZCCHC14
 zinc finger, CCHC domain containing 14
 24019
 0.15
chr3_171048537_171048688 0.27 TNIK
 TRAF2 and NCK interacting kinase
 105112
 0.07
chr3_33058315_33058653 0.27 CCR4
 chemokine (C-C motif) receptor 4
 65418
 0.1
chr14_20946058_20946209 0.27 PNP
 purine nucleoside phosphorylase
 7448
 0.09
chr16_88526692_88526843 0.26 ZFPM1
 zinc finger protein, FOG family member 1
 7042
 0.17
chr1_236619884_236620158 0.26 LGALS8
 lectin, galactoside-binding, soluble, 8
 61279
 0.1
chr5_82367262_82367413 0.26 TMEM167A
 transmembrane protein 167A
 5978
 0.21
chr3_52488454_52488656 0.26 TNNC1
 troponin C type 1 (slow)
 469
 0.48
chr1_160180142_160180293 0.26 RP11-536C5.7
1558
 0.22
chr2_12402850_12403151 0.26 ENSG00000264089
 .
 63744
 0.14
chr2_113408477_113408628 0.26 SLC20A1
 solute carrier family 20 (phosphate transporter), member 1
 3273
 0.25
chr18_25763319_25763470 0.26 CDH2
 cadherin 2, type 1, N-cadherin (neuronal)
 5984
 0.35
chr10_50543603_50543754 0.26 C10orf71
 chromosome 10 open reading frame 71
 36440
 0.14
chr6_143176162_143176486 0.26 HIVEP2
 human immunodeficiency virus type I enhancer binding protein 2
 18140
 0.26
chr2_168944789_168944940 0.25 AC016723.4
147210
 0.04
chr16_3858533_3859115 0.25 CREBBP
 CREB binding protein
 27956
 0.18
chr3_20140501_20140652 0.25 ENSG00000266745
 .
 38481
 0.14
chr17_9372555_9372860 0.25 RP11-565F19.4
4648
 0.22
chr17_33586904_33587190 0.25 SLFN5
 schlafen family member 5
 16939
 0.14
chr15_85568488_85568639 0.25 PDE8A
 phosphodiesterase 8A
 43351
 0.14
chr6_26431904_26432055 0.25 BTN3A3
 butyrophilin, subfamily 3, member A3
 8721
 0.11
chr6_167363091_167363526 0.24 RP11-514O12.4
6304
 0.15
chr1_26104614_26104765 0.24 SEPN1
 selenoprotein N, 1
 21978
 0.11
chr12_107163035_107163186 0.24 RIC8B
 RIC8 guanine nucleotide exchange factor B
 5263
 0.2
chr21_32726723_32726970 0.24 TIAM1
 T-cell lymphoma invasion and metastasis 1
 10252
 0.3
chr19_17859765_17860062 0.24 FCHO1
 FCH domain only 1
 1342
 0.33
chr4_122062374_122062525 0.24 TNIP3
 TNFAIP3 interacting protein 3
 605
 0.79
chr8_67380138_67380289 0.23 C8orf46
 chromosome 8 open reading frame 46
 25230
 0.15
chr7_130612928_130613210 0.23 ENSG00000226380
 .
 50771
 0.14
chr20_57588977_57589482 0.23 TUBB1
 tubulin, beta 1 class VI
 5080
 0.16
chr4_81206298_81206449 0.23 FGF5
 fibroblast growth factor 5
 18580
 0.23
chr17_57451539_57452133 0.23 ENSG00000263857
 .
 8392
 0.18
chr12_2904079_2904230 0.23 FKBP4
 FK506 binding protein 4, 59kDa
 35
 0.96
chr1_90150394_90150545 0.23 LRRC8C
 leucine rich repeat containing 8 family, member C
 51838
 0.11
chr1_232749346_232749497 0.23 SIPA1L2
 signal-induced proliferation-associated 1 like 2
 52117
 0.16
chr13_49305826_49306042 0.23 ENSG00000222391
 .
 20358
 0.22
chr2_198735000_198735151 0.22 PLCL1
 phospholipase C-like 1
 60093
 0.13
chr16_4883813_4884247 0.22 GLYR1
 glyoxylate reductase 1 homolog (Arabidopsis)
 1808
 0.24
chr2_7790268_7790419 0.22 ENSG00000221255
 .
 73371
 0.13
chr10_25170329_25170480 0.22 ENSG00000240294
 .
 27337
 0.21
chr1_201599151_201599302 0.22 NAV1
 neuron navigator 1
 6625
 0.17
chr10_103640072_103640223 0.22 KCNIP2
 Kv channel interacting protein 2
 36470
 0.13
chr2_199739259_199739410 0.22 ENSG00000252511
 .
 307881
 0.01
chr2_235373591_235373785 0.22 ARL4C
 ADP-ribosylation factor-like 4C
 31556
 0.25
chr20_4669801_4670007 0.22 PRNP
 prion protein
 2715
 0.3
chr3_115429117_115429268 0.22 RP11-326J18.1
51812
 0.17
chr3_176859016_176859167 0.22 ENSG00000200882
 .
 15183
 0.21
chr5_172466689_172466840 0.22 ENSG00000207210
 .
 12794
 0.14
chr10_95270559_95270710 0.21 ENSG00000212396
 .
 197
 0.93
chr10_125200637_125200788 0.21 ENSG00000265463
 .
 225008
 0.02
chr16_8968407_8968700 0.21 RP11-77H9.6
5445
 0.14
chr4_99947530_99947681 0.21 METAP1
 methionyl aminopeptidase 1
 5193
 0.19
chr8_42567470_42567887 0.21 RP11-412B14.1
9411
 0.19
chr2_43862754_43862905 0.21 PLEKHH2
 pleckstrin homology domain containing, family H (with MyTH4 domain) member 2
 1583
 0.4
chr13_41059091_41059301 0.21 AL133318.1
 Uncharacterized protein
 52127
 0.15
chr12_11003916_11004067 0.21 PRR4
 proline rich 4 (lacrimal)
 1917
 0.23
chr7_127019301_127019728 0.21 ZNF800
 zinc finger protein 800
 12658
 0.23
chr15_69753129_69753280 0.21 ENSG00000207119
 .
 2716
 0.21
chr14_99732032_99732183 0.21 AL109767.1
2822
 0.29
chr3_99976178_99976329 0.21 TBC1D23
 TBC1 domain family, member 23
 3591
 0.24
chr14_53385303_53385504 0.21 FERMT2
 fermitin family member 2
 654
 0.79
chr19_8523456_8523607 0.20 HNRNPM
 heterogeneous nuclear ribonucleoprotein M
 4850
 0.13
chr4_90210345_90210496 0.20 GPRIN3
 GPRIN family member 3
 18741
 0.28
chr3_23900541_23900775 0.20 UBE2E1
 ubiquitin-conjugating enzyme E2E 1
 47709
 0.12
chr6_161501463_161501614 0.20 MAP3K4
 mitogen-activated protein kinase kinase kinase 4
 58312
 0.13
chr15_86253698_86253896 0.20 RP11-815J21.1
9457
 0.11
chr11_35202633_35202804 0.20 CD44
 CD44 molecule (Indian blood group)
 892
 0.55
chr12_64581902_64582053 0.20 ENSG00000212298
 .
 16596
 0.15
chr3_159516751_159516902 0.20 ENSG00000252763
 .
 9533
 0.17
chr1_233058479_233058642 0.20 NTPCR
 nucleoside-triphosphatase, cancer-related
 27810
 0.23
chrX_135773962_135774298 0.20 CD40LG
 CD40 ligand
 43744
 0.12
chr1_158899632_158899783 0.20 PYHIN1
 pyrin and HIN domain family, member 1
 879
 0.64
chr15_57350008_57350159 0.20 ENSG00000222586
 .
 91488
 0.09
chr19_7310546_7310697 0.20 ENSG00000265748
 .
 1358
 0.43
chr5_54284202_54284433 0.20 ESM1
 endothelial cell-specific molecule 1
 2826
 0.22
chr15_101112044_101112245 0.20 ENSG00000200095
 .
 11147
 0.13
chr11_35818026_35818177 0.20 RP11-698N11.4
17781
 0.22
chr1_167483983_167484134 0.20 CD247
 CD247 molecule
 3717
 0.25
chr2_106670495_106670650 0.19 C2orf40
 chromosome 2 open reading frame 40
 9178
 0.28
chr7_142500387_142500538 0.19 PRSS3P2
 protease, serine, 3 pseudogene 2
 19331
 0.16
chr9_117358198_117358349 0.19 ATP6V1G1
 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1
 8247
 0.15
chr10_114138756_114138907 0.19 ACSL5
 acyl-CoA synthetase long-chain family member 5
 2874
 0.26
chr8_38799337_38799488 0.19 CTD-2544N14.3
31118
 0.12
chr8_67625996_67626573 0.19 SGK3
 serum/glucocorticoid regulated kinase family, member 3
 1631
 0.35
chr1_11628940_11629091 0.19 PTCHD2
 patched domain containing 2
 35282
 0.15
chr1_169541664_169541815 0.19 F5
 coagulation factor V (proaccelerin, labile factor)
 13980
 0.21
chr17_17028767_17028919 0.19 MPRIP
 myosin phosphatase Rho interacting protein
 6137
 0.17
chr5_109042881_109043032 0.19 ENSG00000202512
 .
 7421
 0.21
chr22_45048071_45048222 0.19 PRR5
 proline rich 5 (renal)
 16447
 0.22
chr10_74019506_74020125 0.19 DDIT4
 DNA-damage-inducible transcript 4
 13863
 0.14
chr2_162852542_162852808 0.19 AC008063.2
77091
 0.09
chr6_11755809_11755960 0.19 ADTRP
 androgen-dependent TFPI-regulating protein
 19995
 0.24
chr5_139737036_139737247 0.19 CTC-329D1.3
238
 0.87
chr5_142353044_142353453 0.19 ARHGAP26
 Rho GTPase activating protein 26
 63513
 0.14
chr2_9941357_9941799 0.19 TAF1B
 TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa
 41905
 0.16
chr3_27538031_27538309 0.19 SLC4A7
 solute carrier family 4, sodium bicarbonate cotransporter, member 7
 12283
 0.19
chr6_137187950_137188101 0.19 ENSG00000201807
 .
 11056
 0.19
chr7_6519939_6520326 0.19 FLJ20306
 CDNA FLJ20306 fis, clone HEP06881; Putative uncharacterized protein FLJ20306; Uncharacterized protein
 2790
 0.19
chr2_30645464_30645766 0.19 ENSG00000221377
 .
 9699
 0.25
chr4_103496416_103496598 0.19 NFKB1
 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
 2364
 0.33
chr2_99310867_99311018 0.19 MGAT4A
 mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
 31006
 0.18
chr14_53191688_53191839 0.19 STYX
 serine/threonine/tyrosine interacting protein
 5135
 0.17
chr17_53170721_53170982 0.19 STXBP4
 syntaxin binding protein 4
 93674
 0.08
chr5_888889_889040 0.19 BRD9
 bromodomain containing 9
 850
 0.56
chr11_17308167_17308358 0.18 NUCB2
 nucleobindin 2
 8609
 0.21
chr15_31361367_31361518 0.18 TRPM1
 transient receptor potential cation channel, subfamily M, member 1
 794
 0.62
chr2_65347166_65347317 0.18 RAB1A
 RAB1A, member RAS oncogene family
 9994
 0.2
chr11_123063107_123063391 0.18 CLMP
 CXADR-like membrane protein
 2740
 0.27
chr20_19991270_19991421 0.18 NAA20
 N(alpha)-acetyltransferase 20, NatB catalytic subunit
 6415
 0.22
chr17_75966114_75966265 0.18 TNRC6C
 trinucleotide repeat containing 6C
 34060
 0.15
chr8_129074961_129075246 0.18 ENSG00000221176
 .
 13705
 0.21
chr20_51000199_51000350 0.18 ZFP64
 ZFP64 zinc finger protein
 191749
 0.03
chr2_65547348_65547499 0.18 SPRED2
 sprouty-related, EVH1 domain containing 2
 14484
 0.23
chr21_37661224_37661544 0.18 ENSG00000238851
 .
 30555
 0.12
chr14_68206256_68206407 0.18 ENSG00000252792
 .
 5860
 0.12
chr10_3468664_3468815 0.18 PITRM1
 pitrilysin metallopeptidase 1
 253736
 0.02
chr15_79197342_79197493 0.18 ENSG00000252061
 .
 6139
 0.19
chr1_184860081_184860278 0.18 ENSG00000252222
 .
 69556
 0.11
chr16_9045107_9045455 0.18 USP7
 ubiquitin specific peptidase 7 (herpes virus-associated)
 4956
 0.23
chr14_52821102_52821350 0.18 PTGER2
 prostaglandin E receptor 2 (subtype EP2), 53kDa
 40113
 0.19
chr11_3036599_3036866 0.18 CARS-AS1
 CARS antisense RNA 1
 13892
 0.12
chr2_162057078_162057353 0.18 TANK
 TRAF family member-associated NFKB activator
 21083
 0.19
chr3_71049205_71049356 0.18 FOXP1
 forkhead box P1
 64797
 0.14
chr17_30812882_30813486 0.18 CDK5R1
 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
 453
 0.72
chr2_191903203_191903354 0.18 ENSG00000231858
 .
 17026
 0.16
chr5_156662271_156662422 0.18 ENSG00000222086
 .
 37
 0.97
chr18_42234292_42234443 0.18 SETBP1
 SET binding protein 1
 25771
 0.28
chr6_139265586_139265802 0.18 REPS1
 RALBP1 associated Eps domain containing 1
 14560
 0.24
chr5_156994069_156994363 0.18 AC106801.1
1244
 0.41
chr5_137363231_137363382 0.18 RP11-325L7.1
5157
 0.15
chr18_21552194_21552388 0.18 TTC39C
 tetratricopeptide repeat domain 39C
 20446
 0.16
chr18_2589430_2589655 0.18 NDC80
 NDC80 kinetochore complex component
 11694
 0.14
chr12_56414258_56414409 0.18 IKZF4
 IKAROS family zinc finger 4 (Eos)
 499
 0.6
chr16_53412159_53412330 0.18 RP11-44F14.1
5249
 0.19

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

StringDB image

First level regulatory network of RORC

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.0 0.1 GO:0032971 regulation of muscle filament sliding(GO:0032971) regulation of actin filament-based movement(GO:1903115)
0.0 0.1 GO:1903054 regulation of extracellular matrix disassembly(GO:0010715) negative regulation of extracellular matrix disassembly(GO:0010716) regulation of extracellular matrix organization(GO:1903053) negative regulation of extracellular matrix organization(GO:1903054)
0.0 0.1 GO:0018076 N-terminal peptidyl-lysine acetylation(GO:0018076)
0.0 0.1 GO:0045589 regulation of regulatory T cell differentiation(GO:0045589)
0.0 0.1 GO:0071364 cellular response to epidermal growth factor stimulus(GO:0071364)
0.0 0.0 GO:0051533 positive regulation of NFAT protein import into nucleus(GO:0051533)
0.0 0.0 GO:0032823 regulation of natural killer cell differentiation(GO:0032823) positive regulation of natural killer cell differentiation(GO:0032825)
0.0 0.1 GO:0070050 neuron cellular homeostasis(GO:0070050)
0.0 0.1 GO:0002890 negative regulation of B cell mediated immunity(GO:0002713) negative regulation of immunoglobulin mediated immune response(GO:0002890)
0.0 0.1 GO:0001514 selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.0 0.1 GO:0002710 negative regulation of T cell mediated immunity(GO:0002710)
0.0 0.1 GO:0072162 mesenchymal cell differentiation involved in kidney development(GO:0072161) metanephric mesenchymal cell differentiation(GO:0072162) mesenchymal cell differentiation involved in renal system development(GO:2001012)
0.0 0.2 GO:0048013 ephrin receptor signaling pathway(GO:0048013)
0.0 0.1 GO:1901797 negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518) negative regulation of signal transduction by p53 class mediator(GO:1901797)
0.0 0.1 GO:0001766 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.0 0.1 GO:0019276 UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.0 0.1 GO:0072131 kidney mesenchyme morphogenesis(GO:0072131) metanephric mesenchyme morphogenesis(GO:0072133)
0.0 0.1 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.0 0.1 GO:0032413 negative regulation of ion transmembrane transporter activity(GO:0032413)
0.0 0.1 GO:0070172 positive regulation of tooth mineralization(GO:0070172)
0.0 0.1 GO:0032506 cytokinetic process(GO:0032506)
0.0 0.1 GO:0032695 negative regulation of interleukin-12 production(GO:0032695)
0.0 0.0 GO:0072217 negative regulation of metanephros development(GO:0072217)
0.0 0.1 GO:0017182 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.0 0.0 GO:0090322 regulation of superoxide metabolic process(GO:0090322)
0.0 0.2 GO:0007413 axonal fasciculation(GO:0007413)
0.0 0.1 GO:0033173 calcineurin-NFAT signaling cascade(GO:0033173)
0.0 0.1 GO:0070602 centromeric sister chromatid cohesion(GO:0070601) regulation of centromeric sister chromatid cohesion(GO:0070602)
0.0 0.1 GO:0072526 pyridine-containing compound catabolic process(GO:0072526)
0.0 0.1 GO:0010867 positive regulation of triglyceride biosynthetic process(GO:0010867)
0.0 0.1 GO:0035024 negative regulation of Rho protein signal transduction(GO:0035024)
0.0 0.1 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.0 0.1 GO:0002507 tolerance induction(GO:0002507)
0.0 0.0 GO:0034122 negative regulation of toll-like receptor signaling pathway(GO:0034122)
0.0 0.0 GO:0033591 response to L-ascorbic acid(GO:0033591)
0.0 0.1 GO:0007500 mesodermal cell fate determination(GO:0007500)
0.0 0.0 GO:0060523 prostate epithelial cord elongation(GO:0060523)
0.0 0.1 GO:0090286 cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.0 0.1 GO:0032693 negative regulation of interleukin-10 production(GO:0032693)
0.0 0.0 GO:0071803 regulation of podosome assembly(GO:0071801) positive regulation of podosome assembly(GO:0071803)
0.0 0.1 GO:0045603 positive regulation of endothelial cell differentiation(GO:0045603)
0.0 0.1 GO:0045793 positive regulation of cell size(GO:0045793)
0.0 0.0 GO:0030423 targeting of mRNA for destruction involved in RNA interference(GO:0030423)
0.0 0.1 GO:0090201 negative regulation of mitochondrion organization(GO:0010823) negative regulation of release of cytochrome c from mitochondria(GO:0090201) negative regulation of apoptotic signaling pathway(GO:2001234)
0.0 0.1 GO:0060088 auditory receptor cell morphogenesis(GO:0002093) auditory receptor cell stereocilium organization(GO:0060088)
0.0 0.1 GO:0048535 lymph node development(GO:0048535)
0.0 0.0 GO:0070682 proteasome regulatory particle assembly(GO:0070682)
0.0 0.0 GO:0031167 rRNA methylation(GO:0031167)
0.0 0.1 GO:0002726 positive regulation of T cell cytokine production(GO:0002726)
0.0 0.1 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.0 0.1 GO:2000794 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501) epithelial cell proliferation involved in lung morphogenesis(GO:0060502) regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000794)
0.0 0.2 GO:0006825 copper ion transport(GO:0006825)
0.0 0.1 GO:0060762 regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
0.0 0.1 GO:0045348 positive regulation of MHC class II biosynthetic process(GO:0045348)
0.0 0.0 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0 0.0 GO:0034626 fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 0.0 GO:0060242 contact inhibition(GO:0060242)
0.0 0.0 GO:0009301 snRNA transcription(GO:0009301)
0.0 0.1 GO:0007256 activation of JNKK activity(GO:0007256)
0.0 0.0 GO:0032261 purine nucleotide salvage(GO:0032261)
0.0 0.0 GO:0045978 negative regulation of nucleoside metabolic process(GO:0045978) negative regulation of ATP metabolic process(GO:1903579)
0.0 0.2 GO:0019059 obsolete initiation of viral infection(GO:0019059)
0.0 0.0 GO:0031946 regulation of glucocorticoid biosynthetic process(GO:0031946)
0.0 0.1 GO:0044341 sodium-dependent phosphate transport(GO:0044341)
0.0 0.1 GO:0032075 positive regulation of nuclease activity(GO:0032075)
0.0 0.0 GO:1900115 sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.0 0.0 GO:0030422 production of siRNA involved in RNA interference(GO:0030422)
0.0 0.0 GO:0050862 positive regulation of T cell receptor signaling pathway(GO:0050862)
0.0 0.1 GO:0042989 sequestering of actin monomers(GO:0042989)
0.0 0.1 GO:0060558 regulation of vitamin metabolic process(GO:0030656) vitamin D biosynthetic process(GO:0042368) regulation of vitamin D biosynthetic process(GO:0060556) regulation of calcidiol 1-monooxygenase activity(GO:0060558)
0.0 0.1 GO:0045086 positive regulation of interleukin-2 biosynthetic process(GO:0045086)
0.0 0.0 GO:0010903 negative regulation of very-low-density lipoprotein particle remodeling(GO:0010903)
0.0 0.0 GO:0060049 regulation of protein glycosylation(GO:0060049)
0.0 0.0 GO:0003100 regulation of systemic arterial blood pressure by endothelin(GO:0003100)
0.0 0.0 GO:0035520 monoubiquitinated protein deubiquitination(GO:0035520)
0.0 0.1 GO:0007172 signal complex assembly(GO:0007172)
0.0 0.0 GO:0048149 behavioral response to ethanol(GO:0048149)
0.0 0.1 GO:0031641 regulation of myelination(GO:0031641)
0.0 0.0 GO:2000114 regulation of establishment of cell polarity(GO:2000114)
0.0 0.0 GO:0072311 renal filtration cell differentiation(GO:0061318) glomerular epithelium development(GO:0072010) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.0 0.0 GO:0031936 negative regulation of chromatin silencing(GO:0031936)
0.0 0.0 GO:0018206 peptidyl-methionine modification(GO:0018206)
0.0 0.0 GO:0010792 DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792) double-strand break repair via single-strand annealing(GO:0045002)
0.0 0.0 GO:0022038 corpus callosum development(GO:0022038)
0.0 0.0 GO:0042535 positive regulation of tumor necrosis factor biosynthetic process(GO:0042535)
0.0 0.0 GO:0046642 negative regulation of alpha-beta T cell proliferation(GO:0046642)
0.0 0.0 GO:0019987 obsolete negative regulation of anti-apoptosis(GO:0019987)
0.0 0.0 GO:0050687 negative regulation of defense response to virus(GO:0050687)
0.0 0.0 GO:0010457 centriole-centriole cohesion(GO:0010457)
0.0 0.1 GO:0000183 chromatin silencing at rDNA(GO:0000183)
0.0 0.3 GO:0050690 regulation of defense response to virus by virus(GO:0050690)
0.0 0.1 GO:0070536 protein K63-linked deubiquitination(GO:0070536)
0.0 0.1 GO:0050891 renal water homeostasis(GO:0003091) multicellular organismal water homeostasis(GO:0050891)
0.0 0.0 GO:0006172 ADP biosynthetic process(GO:0006172) purine nucleoside diphosphate biosynthetic process(GO:0009136) purine ribonucleoside diphosphate biosynthetic process(GO:0009180) ribonucleoside diphosphate biosynthetic process(GO:0009188)
0.0 0.0 GO:0051088 PMA-inducible membrane protein ectodomain proteolysis(GO:0051088)
0.0 0.0 GO:0000492 small nucleolar ribonucleoprotein complex assembly(GO:0000491) box C/D snoRNP assembly(GO:0000492)
0.0 0.0 GO:0046877 regulation of saliva secretion(GO:0046877)
0.0 0.0 GO:0071480 cellular response to gamma radiation(GO:0071480)
0.0 0.0 GO:0009313 oligosaccharide catabolic process(GO:0009313)
0.0 0.0 GO:0060122 inner ear receptor stereocilium organization(GO:0060122)
0.0 0.0 GO:0045059 positive thymic T cell selection(GO:0045059)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.0 0.1 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.0 0.1 GO:0071438 invadopodium membrane(GO:0071438)
0.0 0.1 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.0 0.1 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.0 0.1 GO:0070695 FHF complex(GO:0070695)
0.0 0.1 GO:0042272 nuclear RNA export factor complex(GO:0042272)
0.0 0.1 GO:0034992 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 0.1 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 0.1 GO:0000275 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275)
0.0 0.0 GO:0032449 CBM complex(GO:0032449)
0.0 0.1 GO:0016012 sarcoglycan complex(GO:0016012)
0.0 0.1 GO:0042587 glycogen granule(GO:0042587)
0.0 0.1 GO:0005828 kinetochore microtubule(GO:0005828)
0.0 0.1 GO:0005916 fascia adherens(GO:0005916)
0.0 0.0 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.0 0.1 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0 0.0 GO:0005638 lamin filament(GO:0005638)
0.0 0.1 GO:0005606 laminin-1 complex(GO:0005606)
0.0 0.0 GO:0002139 stereocilia coupling link(GO:0002139) stereocilia ankle link(GO:0002141) stereocilia ankle link complex(GO:0002142)
0.0 0.1 GO:0001772 immunological synapse(GO:0001772)
0.0 0.1 GO:0071203 WASH complex(GO:0071203)
0.0 0.1 GO:0098642 network-forming collagen trimer(GO:0098642) collagen network(GO:0098645)
0.0 0.0 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 0.1 GO:0005861 troponin complex(GO:0005861)
0.0 0.0 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0004800 thyroxine 5'-deiodinase activity(GO:0004800)
0.0 0.2 GO:0015925 galactosidase activity(GO:0015925)
0.0 0.2 GO:0048156 tau protein binding(GO:0048156)
0.0 0.1 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0 0.3 GO:0016493 C-C chemokine receptor activity(GO:0016493)
0.0 0.1 GO:0031014 troponin T binding(GO:0031014)
0.0 0.1 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 0.1 GO:0016530 metallochaperone activity(GO:0016530)
0.0 0.1 GO:0043515 kinetochore binding(GO:0043515)
0.0 0.1 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0 0.1 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.0 0.1 GO:0030235 nitric-oxide synthase regulator activity(GO:0030235)
0.0 0.1 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 0.1 GO:0042153 obsolete RPTP-like protein binding(GO:0042153)
0.0 0.1 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.0 0.2 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.1 GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.0 0.1 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 0.1 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.0 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.0 0.0 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.0 0.2 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.0 0.1 GO:0061630 ubiquitin-ubiquitin ligase activity(GO:0034450) ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659)
0.0 0.2 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.1 GO:0004597 peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.0 0.2 GO:0031593 polyubiquitin binding(GO:0031593)
0.0 0.1 GO:0042171 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) lysophosphatidic acid acyltransferase activity(GO:0042171) lysophospholipid acyltransferase activity(GO:0071617)
0.0 0.1 GO:0016778 diphosphotransferase activity(GO:0016778)
0.0 0.0 GO:0050682 AF-2 domain binding(GO:0050682)
0.0 0.1 GO:0070053 thrombospondin receptor activity(GO:0070053)
0.0 0.1 GO:0016494 C-X-C chemokine receptor activity(GO:0016494)
0.0 0.0 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0 0.0 GO:0030284 estrogen receptor activity(GO:0030284)
0.0 0.0 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)
0.0 0.0 GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.0 0.1 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0 0.1 GO:0051879 Hsp90 protein binding(GO:0051879)
0.0 0.0 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.0 0.1 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.0 0.1 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.1 GO:0030332 cyclin binding(GO:0030332)
0.0 0.0 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.0 0.1 GO:0008266 poly(U) RNA binding(GO:0008266)
0.0 0.0 GO:0002060 purine nucleobase binding(GO:0002060)
0.0 0.0 GO:0008187 poly-pyrimidine tract binding(GO:0008187)
0.0 0.1 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 0.1 GO:0001637 G-protein coupled chemoattractant receptor activity(GO:0001637) chemokine receptor activity(GO:0004950)
0.0 0.0 GO:0004974 leukotriene receptor activity(GO:0004974)
0.0 0.0 GO:0030229 very-low-density lipoprotein particle receptor activity(GO:0030229)
0.0 0.0 GO:0035197 siRNA binding(GO:0035197)
0.0 0.0 GO:0004949 cannabinoid receptor activity(GO:0004949)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.0 0.0 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.0 0.3 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.0 0.2 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.1 PID BETA CATENIN DEG PATHWAY Degradation of beta catenin
0.0 0.1 PID VEGFR1 PATHWAY VEGFR1 specific signals

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME PECAM1 INTERACTIONS Genes involved in PECAM1 interactions
0.0 0.1 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
0.0 0.4 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.2 REACTOME HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
0.0 0.2 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.2 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0 0.2 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 0.1 REACTOME UNFOLDED PROTEIN RESPONSE Genes involved in Unfolded Protein Response
0.0 0.2 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.0 0.2 REACTOME CTNNB1 PHOSPHORYLATION CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.0 0.1 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.1 REACTOME REGULATORY RNA PATHWAYS Genes involved in Regulatory RNA pathways
0.0 0.1 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions