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ENCODE: H3K4me1 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for RXRG

Z-value: 0.82

Motif logo

Transcription factors associated with RXRG

Gene Symbol	Gene ID	Gene Info
RXRG Ensembl NCBI GeneCards UniProt	ENSG00000143171.8	RXRG

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
RXRG	chr1_165393859_165394115	20446	0.212368	0.71	3.0e-02	Click!
RXRG	chr1_165393302_165393453	21056	0.210858	0.66	5.5e-02	Click!
RXRG	chr1_165414517_165414668	159	0.966147	-0.48	1.9e-01	Click!
RXRG	chr1_165414132_165414400	167	0.964415	-0.25	5.1e-01	Click!
RXRG	chr1_165394165_165394316	20193	0.212989	0.20	6.0e-01	Click!

Activity of the RXRG motif across conditions

Conditions sorted by the z-value of the RXRG motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr22_50360662_50360813	0.48	PIM3	pim-3 oncogene	6576	0.19
chr19_51627416_51627752	0.36	SIGLEC9	sialic acid binding Ig-like lectin 9	581	0.56
chr5_133457481_133458118	0.34	TCF7	transcription factor 7 (T-cell specific, HMG-box)	1510	0.45
chr11_67173722_67173982	0.29	TBC1D10C	TBC1 domain family, member 10C	2192	0.12
chr10_72083897_72084209	0.28	NPFFR1	neuropeptide FF receptor 1	40621	0.14
chr19_5952060_5952229	0.27	RANBP3	RAN binding protein 3	25946	0.08
chr8_130696046_130696267	0.27	GSDMC	gasdermin C	102978	0.06
chr17_81011696_81011877	0.26	B3GNTL1	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1	2100	0.35
chr1_77513564_77513779	0.26	RP4-564M11.2		19934	0.23
chr5_169695577_169695892	0.25	LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	1403	0.48
chr17_45779984_45780199	0.25	TBKBP1	TBK1 binding protein 1	7461	0.14
chr4_2418867_2419018	0.25	ZFYVE28	zinc finger, FYVE domain containing 28	1394	0.4
chr6_167460456_167460849	0.25	FGFR1OP	FGFR1 oncogene partner	47756	0.1
chr19_42382114_42382373	0.25	CD79A	CD79a molecule, immunoglobulin-associated alpha	868	0.44
chr2_43439781_43440131	0.24	ZFP36L2	ZFP36 ring finger protein-like 2	13792	0.22
chr14_69290800_69290951	0.24	ENSG00000263694	.	21644	0.18
chr19_7607962_7608247	0.24	PNPLA6	patatin-like phospholipase domain containing 6	3180	0.13
chr20_47401167_47401399	0.24	PREX1	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1	43137	0.17
chr8_87355273_87355424	0.23	WWP1	WW domain containing E3 ubiquitin protein ligase 1	381	0.91
chr5_543677_544187	0.23	ENSG00000264233	.	7935	0.14
chr2_8618267_8618671	0.23	AC011747.7		197427	0.03
chr3_44558841_44559128	0.22	ENSG00000264774	.	2191	0.23
chr11_47416662_47417076	0.22	RP11-750H9.5		322	0.77
chr19_7795290_7795492	0.22	CLEC4G	C-type lectin domain family 4, member G	1666	0.22
chr17_81010368_81010641	0.22	B3GNTL1	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1	818	0.67
chr11_64257656_64257906	0.22	AP003774.4	HCG1652096, isoform CRA_a; Uncharacterized protein; cDNA FLJ37045 fis, clone BRACE2012185	41235	0.11
chr6_110796846_110797132	0.22	SLC22A16	solute carrier family 22 (organic cation/carnitine transporter), member 16	610	0.69
chr19_13205558_13205827	0.21	LYL1	lymphoblastic leukemia derived sequence 1	7989	0.1
chr19_13212572_13212806	0.21	LYL1	lymphoblastic leukemia derived sequence 1	992	0.37
chr6_37924307_37924458	0.21	ZFAND3	zinc finger, AN1-type domain 3	26647	0.2
chr17_55485159_55485393	0.21	ENSG00000263902	.	4286	0.31
chr20_2731303_2731547	0.21	EBF4	early B-cell factor 4	44538	0.08
chr12_113531682_113531833	0.21	DTX1	deltex homolog 1 (Drosophila)	36262	0.1
chr9_92723584_92723735	0.21	ENSG00000263967	.	62158	0.16
chr5_55984183_55984556	0.21	AC022431.2	Homo sapiens uncharacterized LOC101928448 (LOC101928448), mRNA.	82310	0.09
chr14_104928302_104928602	0.20	ENSG00000222761	.	61067	0.12
chr4_1237782_1238175	0.20	CTBP1	C-terminal binding protein 1	2267	0.22
chr1_151025492_151025717	0.20	MLLT11	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11	4630	0.09
chr17_78756379_78756543	0.20	RP11-28G8.1		22971	0.22
chr7_143060122_143060387	0.20	FAM131B	family with sequence similarity 131, member B	409	0.74
chr11_64492185_64492449	0.20	NRXN2	neurexin 2	1657	0.28
chr1_230322984_230323135	0.20	RP5-956O18.2		81170	0.09
chr3_195529321_195529533	0.20	MUC4	mucin 4, cell surface associated	9301	0.2
chr1_845118_845307	0.20	SAMD11	sterile alpha motif domain containing 11	15048	0.11
chr9_92096814_92097125	0.19	SEMA4D	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D	2164	0.36
chr1_156251979_156252130	0.19	SMG5	SMG5 nonsense mediated mRNA decay factor	562	0.43
chr2_10677292_10677443	0.19	AC092687.5		51925	0.13
chr3_52325077_52325228	0.19	GLYCTK	glycerate kinase	822	0.39
chr10_129718614_129719007	0.19	PTPRE	protein tyrosine phosphatase, receptor type, E	13394	0.2
chr4_6945535_6945709	0.19	ENSG00000265953	.	9394	0.15
chr7_100798039_100798250	0.19	AP1S1	adaptor-related protein complex 1, sigma 1 subunit	338	0.77
chr17_37796865_37797043	0.19	STARD3	StAR-related lipid transfer (START) domain containing 3	3331	0.14
chr15_81586884_81587161	0.19	IL16	interleukin 16	2232	0.32
chr17_76253152_76253544	0.19	TMEM235	transmembrane protein 235	25226	0.12
chr16_23869581_23869825	0.19	PRKCB	protein kinase C, beta	21159	0.22
chr15_67358635_67358896	0.19	SMAD3	SMAD family member 3	582	0.84
chr14_102818626_102818777	0.19	ENSG00000239061	.	6538	0.13
chrX_128920075_128920364	0.18	SASH3	SAM and SH3 domain containing 3	6259	0.21
chr12_1906232_1906409	0.18	CACNA2D4	calcium channel, voltage-dependent, alpha 2/delta subunit 4	14566	0.2
chr12_12013969_12014120	0.18	ETV6	ets variant 6	24827	0.26
chr20_4795714_4796665	0.18	RASSF2	Ras association (RalGDS/AF-6) domain family member 2	420	0.85
chr11_85912300_85912516	0.18	EED	embryonic ectoderm development	43178	0.14
chr18_55710965_55711289	0.18	NEDD4L	neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase	472	0.86
chr19_8676750_8676918	0.18	ADAMTS10	ADAM metallopeptidase with thrombospondin type 1 motif, 10	1249	0.4
chr15_75337787_75338089	0.18	PPCDC	phosphopantothenoylcysteine decarboxylase	2322	0.25
chr19_1471924_1472075	0.18	C19orf25	chromosome 19 open reading frame 25	6897	0.07
chr1_155936937_155937092	0.18	ARHGEF2	Rho/Rac guanine nucleotide exchange factor (GEF) 2	2506	0.14
chr1_68151351_68151556	0.18	GADD45A	growth arrest and DNA-damage-inducible, alpha	569	0.8
chr10_73127227_73127403	0.18	CDH23	cadherin-related 23	29376	0.17
chr6_157160099_157160284	0.18	RP11-230C9.3		58602	0.13
chr10_104517058_104517275	0.18	WBP1L	WW domain binding protein 1-like	13439	0.14
chr11_328111_328341	0.17	IFITM3	interferon induced transmembrane protein 3	689	0.43
chr17_79420586_79420890	0.17	ENSG00000266189	.	2524	0.16
chr7_50247596_50247947	0.17	AC020743.2		65352	0.12
chr12_111216861_111217180	0.17	PPP1CC	protein phosphatase 1, catalytic subunit, gamma isozyme	36276	0.16
chr1_109642870_109643021	0.17	ENSG00000270066	.	130	0.93
chr11_2468048_2468289	0.17	KCNQ1	potassium voltage-gated channel, KQT-like subfamily, member 1	1947	0.26
chr1_36945879_36946111	0.17	CSF3R	colony stimulating factor 3 receptor (granulocyte)	898	0.54
chr17_37618451_37618639	0.17	CDK12	cyclin-dependent kinase 12	253	0.9
chr21_46902705_46902925	0.17	COL18A1	collagen, type XVIII, alpha 1	7374	0.21
chr4_54569449_54569737	0.17	LNX1	ligand of numb-protein X 1, E3 ubiquitin protein ligase	2021	0.37
chr6_91004978_91005129	0.17	BACH2	BTB and CNC homology 1, basic leucine zipper transcription factor 2	1408	0.5
chr2_62430640_62430961	0.17	ENSG00000266097	.	2161	0.29
chr19_49920997_49921157	0.17	PTH2	parathyroid hormone 2	5621	0.07
chr17_32964273_32964569	0.17	TMEM132E	transmembrane protein 132E	56653	0.13
chr19_7402652_7402854	0.17	CTB-133G6.1		11095	0.16
chr1_12200334_12200485	0.17	TNFRSF8	tumor necrosis factor receptor superfamily, member 8	14453	0.15
chr2_231527868_231528072	0.17	CAB39	calcium binding protein 39	49590	0.13
chr3_188010595_188010746	0.17	LPP	LIM domain containing preferred translocation partner in lipoma	53018	0.17
chr19_41224754_41224952	0.17	ADCK4	aarF domain containing kinase 4	741	0.46
chr12_96599777_96599928	0.17	ELK3	ELK3, ETS-domain protein (SRF accessory protein 2)	11460	0.2
chr17_7240555_7240902	0.17	ACAP1	ArfGAP with coiled-coil, ankyrin repeat and PH domains 1	819	0.31
chr9_120588985_120589386	0.17	ENSG00000251847	.	95436	0.08
chr7_962089_962318	0.17	ADAP1	ArfGAP with dual PH domains 1	1677	0.3
chr6_161621899_161622078	0.17	AGPAT4	1-acylglycerol-3-phosphate O-acyltransferase 4	51667	0.18
chr17_42392949_42393100	0.17	AC003102.3		341	0.73
chr17_38720722_38720873	0.17	CCR7	chemokine (C-C motif) receptor 7	914	0.56
chr1_160617137_160617535	0.17	SLAMF1	signaling lymphocytic activation molecule family member 1	251	0.91
chr3_111838750_111839161	0.17	ENSG00000207940	.	7307	0.16
chr17_9924432_9924619	0.17	GAS7	growth arrest-specific 7	1066	0.59
chr19_16228343_16228511	0.16	RAB8A	RAB8A, member RAS oncogene family	5720	0.14
chr17_45911855_45912006	0.16	LRRC46	leucine rich repeat containing 46	2937	0.14
chr11_64401610_64401843	0.16	NRXN2	neurexin 2	8432	0.15
chr16_17568308_17568782	0.16	XYLT1	xylosyltransferase I	3807	0.39
chr17_71736626_71736794	0.16	SDK2	sidekick cell adhesion molecule 2	96482	0.08
chr11_64568441_64568592	0.16	MAP4K2	mitogen-activated protein kinase kinase kinase kinase 2	2131	0.19
chr15_92023442_92023593	0.16	SV2B	synaptic vesicle glycoprotein 2B	254417	0.02
chr2_220075581_220075882	0.16	ZFAND2B	zinc finger, AN1-type domain 2B	2551	0.11
chr11_63305751_63305902	0.16	RARRES3	retinoic acid receptor responder (tazarotene induced) 3	42	0.97
chr19_16395394_16395593	0.16	CTD-2562J15.6		8893	0.16
chr1_9797259_9797436	0.16	CLSTN1	calsyntenin 1	14292	0.17
chr12_69166647_69166888	0.16	AC124890.1	HCG1774533, isoform CRA_a; PRO2268; Uncharacterized protein	19358	0.14
chr19_50063674_50064142	0.16	NOSIP	nitric oxide synthase interacting protein	21	0.93
chr11_44117733_44117933	0.16	EXT2	exostosin glycosyltransferase 2	60	0.97
chr19_13067455_13067695	0.16	GADD45GIP1	growth arrest and DNA-damage-inducible, gamma interacting protein 1	475	0.54
chr2_46502581_46502732	0.16	EPAS1	endothelial PAS domain protein 1	21091	0.24
chr17_79478415_79478566	0.16	ENSG00000266077	.	355	0.7
chr19_3671752_3672026	0.16	AC004637.1		691	0.55
chr14_102063212_102063453	0.16	DIO3	deiodinase, iodothyronine, type III	35644	0.15
chr2_128242825_128243074	0.16	ENSG00000202429	.	13139	0.14
chr10_100202612_100202763	0.16	HPS1	Hermansky-Pudlak syndrome 1	3980	0.22
chr13_113438175_113438326	0.16	ATP11A	ATPase, class VI, type 11A	1236	0.5
chr19_6767196_6767347	0.16	SH2D3A	SH2 domain containing 3A	175	0.92
chr1_31234795_31234983	0.16	LAPTM5	lysosomal protein transmembrane 5	4222	0.2
chr19_16369309_16369616	0.16	AP1M1	adaptor-related protein complex 1, mu 1 subunit	31046	0.12
chr16_88706951_88707212	0.16	IL17C	interleukin 17C	2080	0.17
chr22_32596610_32596827	0.16	RFPL2	ret finger protein-like 2	2746	0.21
chr1_235096750_235097092	0.16	ENSG00000239690	.	56988	0.14
chr18_2848147_2848503	0.16	EMILIN2	elastin microfibril interfacer 2	1297	0.4
chr2_110962298_110962466	0.16	NPHP1	nephronophthisis 1 (juvenile)	167	0.96
chr15_81616223_81616414	0.16	STARD5	StAR-related lipid transfer (START) domain containing 5	148	0.78
chr16_79308560_79308711	0.16	ENSG00000222244	.	10284	0.3
chr6_90984611_90985132	0.16	BACH2	BTB and CNC homology 1, basic leucine zipper transcription factor 2	21590	0.23
chr7_73117969_73118147	0.16	ENSG00000265724	.	7589	0.1
chr11_4004733_4004995	0.16	STIM1	stromal interaction molecule 1	36291	0.14
chr7_127292633_127293077	0.16	SND1	staphylococcal nuclease and tudor domain containing 1	621	0.5
chr2_38512547_38512698	0.16	ATL2	atlastin GTPase 2	90744	0.08
chr3_38415523_38415797	0.16	XYLB	xylulokinase homolog (H. influenzae)	27314	0.16
chr17_7747631_7748159	0.16	KDM6B	lysine (K)-specific demethylase 6B	338	0.77
chr19_15385020_15385239	0.16	BRD4	bromodomain containing 4	6133	0.19
chr15_78395791_78396151	0.16	SH2D7	SH2 domain containing 7	11044	0.13
chr15_55549033_55549184	0.16	RAB27A	RAB27A, member RAS oncogene family	7875	0.22
chrX_48973868_48974136	0.16	GPKOW	G patch domain and KOW motifs	6149	0.09
chr17_74268830_74269044	0.16	UBALD2	UBA-like domain containing 2	7153	0.13
chr16_27410389_27410773	0.15	IL21R	interleukin 21 receptor	2902	0.28
chr14_102664211_102664362	0.15	WDR20	WD repeat domain 20	3003	0.26
chr15_91380724_91380980	0.15	CTD-3094K11.1		2102	0.22
chr8_134079341_134079492	0.15	SLA	Src-like-adaptor	6813	0.26
chr14_101875137_101875288	0.15	ENSG00000258498	.	151547	0.02
chr17_19037709_19038128	0.15	GRAPL	GRB2-related adaptor protein-like	1886	0.17
chr8_68881201_68881427	0.15	PREX2	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2	16961	0.28
chr1_15650780_15650931	0.15	RP3-467K16.7		11105	0.16
chr20_32030445_32030661	0.15	SNTA1	syntrophin, alpha 1	1145	0.46
chr13_40533809_40533960	0.15	ENSG00000212553	.	102520	0.08
chr6_35277451_35277713	0.15	DEF6	differentially expressed in FDCP 6 homolog (mouse)	67	0.97
chrX_129306523_129306726	0.15	RAB33A	RAB33A, member RAS oncogene family	1001	0.56
chr22_35729612_35729777	0.15	ENSG00000266320	.	1939	0.29
chr1_161015258_161015409	0.15	USF1	upstream transcription factor 1	330	0.76
chr5_75637588_75637859	0.15	RP11-466P24.6		30436	0.21
chr22_30679087_30679350	0.15	GATSL3	GATS protein-like 3	6378	0.1
chr11_67050388_67050683	0.15	ANKRD13D	ankyrin repeat domain 13 family, member D	5483	0.12
chr14_93203173_93203394	0.15	LGMN	legumain	11632	0.25
chr15_63570030_63570181	0.15	APH1B	APH1B gamma secretase subunit	288	0.93
chr5_139928576_139928727	0.15	EIF4EBP3	eukaryotic translation initiation factor 4E binding protein 3	1400	0.21
chr1_223351560_223351778	0.15	TLR5	toll-like receptor 5	35045	0.22
chrX_135865687_135865855	0.15	ARHGEF6	Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6	1524	0.38
chr19_18980510_18980983	0.15	AC005197.2		11743	0.11
chr7_30068456_30068607	0.15	PLEKHA8	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8	230	0.9
chr1_9305121_9305314	0.15	H6PD	hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)	5314	0.21
chrX_48792186_48792645	0.15	PIM2	pim-2 oncogene	16114	0.08
chr3_111032298_111032588	0.15	CD96	CD96 molecule	20877	0.27
chr10_14577268_14577434	0.15	FAM107B	family with sequence similarity 107, member B	2642	0.34
chrX_2747833_2747984	0.15	GYG2	glycogenin 2	595	0.71
chr1_54764314_54764483	0.15	RP5-997D24.3		13320	0.18
chr17_18943047_18943488	0.15	GRAP	GRB2-related adaptor protein	2531	0.17
chr7_150132614_150132825	0.15	GIMAP8	GTPase, IMAP family member 8	14999	0.15
chr17_7035953_7036156	0.15	ASGR2	asialoglycoprotein receptor 2	17035	0.1
chr14_89825766_89826160	0.15	RP11-356K23.2		4559	0.2
chr3_18768057_18768243	0.15	ENSG00000228956	.	19086	0.29
chr2_238649424_238649774	0.15	LRRFIP1	leucine rich repeat (in FLII) interacting protein 1	48617	0.13
chr3_52880668_52880966	0.15	TMEM110-MUSTN1	TMEM110-MUSTN1 readthrough	3854	0.13
chr17_4881765_4881941	0.15	RP5-1050D4.2		5707	0.06
chr9_36150617_36150840	0.15	GLIPR2	GLI pathogenesis-related 2	13986	0.17
chr1_22788372_22788560	0.15	ZBTB40	zinc finger and BTB domain containing 40	9994	0.23
chr14_23495394_23495545	0.15	ENSG00000207765	.	7378	0.08
chr1_161160490_161160641	0.15	ADAMTS4	ADAM metallopeptidase with thrombospondin type 1 motif, 4	8278	0.06
chr6_159540709_159540860	0.14	RP11-13P5.2		47601	0.13
chr17_72984009_72984428	0.14	CDR2L	cerebellar degeneration-related protein 2-like	491	0.63
chr2_19560748_19560899	0.14	OSR1	odd-skipped related transciption factor 1	2409	0.37
chr22_24828899_24829111	0.14	ADORA2A	adenosine A2a receptor	197	0.94
chr2_239068958_239069217	0.14	FAM132B	family with sequence similarity 132, member B	1438	0.32
chr2_113993602_113993853	0.14	ENSG00000189223	.	87	0.91
chr9_136925319_136925470	0.14	BRD3	bromodomain containing 3	4260	0.19
chr10_73830371_73830560	0.14	SPOCK2	sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2	17621	0.22
chr6_2516451_2516602	0.14	ENSG00000266252	.	106657	0.07
chr5_150600157_150600636	0.14	CCDC69	coiled-coil domain containing 69	3310	0.24
chr2_113944916_113945243	0.14	PSD4	pleckstrin and Sec7 domain containing 4	8778	0.14
chr16_50728117_50728492	0.14	NOD2	nucleotide-binding oligomerization domain containing 2	767	0.52
chr19_39616574_39617021	0.14	PAK4	p21 protein (Cdc42/Rac)-activated kinase 4	323	0.84
chr1_226839780_226839931	0.14	ITPKB-IT1	ITPKB intronic transcript 1 (non-protein coding)	7516	0.22

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of RXRG

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.1	GO:0002448	mast cell mediated immunity(GO:0002448)
0.1	0.2	GO:0014056	acetylcholine secretion, neurotransmission(GO:0014055) regulation of acetylcholine secretion, neurotransmission(GO:0014056) acetylcholine secretion(GO:0061526)
0.1	0.2	GO:0015014	heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.1	0.2	GO:0030223	neutrophil differentiation(GO:0030223)
0.1	0.2	GO:0006883	cellular sodium ion homeostasis(GO:0006883)
0.1	0.2	GO:0035405	histone-threonine phosphorylation(GO:0035405)
0.0	0.1	GO:0016242	negative regulation of macroautophagy(GO:0016242)
0.0	0.1	GO:0019049	evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.0	0.1	GO:0045990	carbon catabolite regulation of transcription(GO:0045990) regulation of transcription by glucose(GO:0046015)
0.0	0.1	GO:0006651	diacylglycerol biosynthetic process(GO:0006651)
0.0	0.1	GO:0001865	NK T cell differentiation(GO:0001865) regulation of NK T cell differentiation(GO:0051136) positive regulation of NK T cell differentiation(GO:0051138)
0.0	0.1	GO:0072239	metanephric glomerulus development(GO:0072224) metanephric glomerulus vasculature development(GO:0072239)
0.0	0.2	GO:0070670	response to interleukin-4(GO:0070670)
0.0	0.1	GO:0015917	aminophospholipid transport(GO:0015917)
0.0	0.0	GO:0002513	tolerance induction to self antigen(GO:0002513)
0.0	0.1	GO:0045943	positive regulation of transcription from RNA polymerase I promoter(GO:0045943)
0.0	0.1	GO:0043320	natural killer cell activation involved in immune response(GO:0002323) natural killer cell degranulation(GO:0043320)
0.0	0.1	GO:0010572	positive regulation of platelet activation(GO:0010572)
0.0	0.1	GO:0048548	regulation of pinocytosis(GO:0048548)
0.0	0.1	GO:0032020	ISG15-protein conjugation(GO:0032020)
0.0	0.1	GO:0031061	negative regulation of histone methylation(GO:0031061)
0.0	0.1	GO:0052169	pathogen-associated molecular pattern dependent induction by symbiont of host innate immune response(GO:0052033) positive regulation by symbiont of host innate immune response(GO:0052166) modulation by symbiont of host innate immune response(GO:0052167) pathogen-associated molecular pattern dependent modulation by symbiont of host innate immune response(GO:0052169) pathogen-associated molecular pattern dependent induction by organism of innate immune response of other organism involved in symbiotic interaction(GO:0052257) positive regulation by organism of innate immune response in other organism involved in symbiotic interaction(GO:0052305) modulation by organism of innate immune response in other organism involved in symbiotic interaction(GO:0052306) pathogen-associated molecular pattern dependent modulation by organism of innate immune response in other organism involved in symbiotic interaction(GO:0052308)
0.0	0.1	GO:0046501	protoporphyrinogen IX metabolic process(GO:0046501)
0.0	0.1	GO:1901534	positive regulation of megakaryocyte differentiation(GO:0045654) positive regulation of hematopoietic progenitor cell differentiation(GO:1901534)
0.0	0.0	GO:0002888	positive regulation of myeloid leukocyte mediated immunity(GO:0002888)
0.0	0.1	GO:0007500	mesodermal cell fate determination(GO:0007500)
0.0	0.1	GO:0001778	plasma membrane repair(GO:0001778)
0.0	0.1	GO:0001911	negative regulation of leukocyte mediated cytotoxicity(GO:0001911)
0.0	0.1	GO:0002227	innate immune response in mucosa(GO:0002227) mucosal immune response(GO:0002385)
0.0	0.0	GO:0060242	contact inhibition(GO:0060242)
0.0	0.1	GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway(GO:0007195)
0.0	0.1	GO:0045349	interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354)
0.0	0.1	GO:0034501	protein localization to kinetochore(GO:0034501)
0.0	0.1	GO:0042732	D-xylose metabolic process(GO:0042732)
0.0	0.1	GO:0070874	negative regulation of glycogen metabolic process(GO:0070874)
0.0	0.1	GO:0060391	positive regulation of SMAD protein import into nucleus(GO:0060391)
0.0	0.1	GO:0045722	positive regulation of gluconeogenesis(GO:0045722)
0.0	0.1	GO:0045056	transcytosis(GO:0045056)
0.0	0.1	GO:0046968	peptide antigen transport(GO:0046968)
0.0	0.1	GO:0006689	ganglioside catabolic process(GO:0006689)
0.0	0.1	GO:0009051	pentose-phosphate shunt, oxidative branch(GO:0009051)
0.0	0.0	GO:0003197	endocardial cushion development(GO:0003197)
0.0	0.0	GO:0033004	negative regulation of mast cell activation(GO:0033004)
0.0	0.1	GO:0032914	positive regulation of transforming growth factor beta1 production(GO:0032914)
0.0	0.3	GO:0032011	ARF protein signal transduction(GO:0032011)
0.0	0.0	GO:0032415	regulation of sodium:proton antiporter activity(GO:0032415) regulation of sodium ion transmembrane transport(GO:1902305) regulation of sodium ion transmembrane transporter activity(GO:2000649)
0.0	0.1	GO:0051001	negative regulation of nitric-oxide synthase activity(GO:0051001)
0.0	0.0	GO:2001012	mesenchymal cell differentiation involved in kidney development(GO:0072161) metanephric mesenchymal cell differentiation(GO:0072162) mesenchymal cell differentiation involved in renal system development(GO:2001012)
0.0	0.3	GO:0071479	cellular response to ionizing radiation(GO:0071479)
0.0	0.0	GO:1903429	regulation of neuron maturation(GO:0014041) regulation of cell maturation(GO:1903429)
0.0	0.1	GO:0046322	negative regulation of fatty acid oxidation(GO:0046322)
0.0	0.1	GO:0009186	deoxyribonucleoside diphosphate metabolic process(GO:0009186)
0.0	0.1	GO:0090281	negative regulation of calcium ion import(GO:0090281)
0.0	0.0	GO:0046101	hypoxanthine biosynthetic process(GO:0046101)
0.0	0.1	GO:0090073	positive regulation of protein homodimerization activity(GO:0090073)
0.0	0.1	GO:0006154	adenosine catabolic process(GO:0006154)
0.0	0.1	GO:0003181	atrioventricular valve development(GO:0003171) atrioventricular valve morphogenesis(GO:0003181)
0.0	0.1	GO:0042761	very long-chain fatty acid biosynthetic process(GO:0042761)
0.0	0.0	GO:0030210	heparin metabolic process(GO:0030202) heparin biosynthetic process(GO:0030210)
0.0	0.1	GO:0045059	positive thymic T cell selection(GO:0045059)
0.0	0.2	GO:0015695	organic cation transport(GO:0015695)
0.0	0.1	GO:0018094	protein polyglycylation(GO:0018094)
0.0	0.1	GO:0043615	astrocyte cell migration(GO:0043615)
0.0	0.1	GO:0006198	cAMP catabolic process(GO:0006198)
0.0	0.0	GO:0045603	positive regulation of endothelial cell differentiation(GO:0045603)
0.0	0.0	GO:0010523	negative regulation of calcium ion transport into cytosol(GO:0010523)
0.0	0.2	GO:0045648	positive regulation of erythrocyte differentiation(GO:0045648)
0.0	0.0	GO:0051712	positive regulation of killing of cells of other organism(GO:0051712)
0.0	0.1	GO:0060080	inhibitory postsynaptic potential(GO:0060080)
0.0	0.0	GO:0048807	female genitalia morphogenesis(GO:0048807)
0.0	0.1	GO:0006002	fructose 6-phosphate metabolic process(GO:0006002)
0.0	0.0	GO:0018076	N-terminal peptidyl-lysine acetylation(GO:0018076)
0.0	0.0	GO:0060235	lens induction in camera-type eye(GO:0060235)
0.0	0.0	GO:0002478	antigen processing and presentation of exogenous peptide antigen(GO:0002478)
0.0	0.1	GO:0006600	creatine metabolic process(GO:0006600)
0.0	0.1	GO:0032957	inositol trisphosphate metabolic process(GO:0032957)
0.0	0.0	GO:0033629	negative regulation of cell adhesion mediated by integrin(GO:0033629)
0.0	0.1	GO:0001955	blood vessel maturation(GO:0001955)
0.0	0.0	GO:0045343	MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343)
0.0	0.1	GO:0045577	regulation of B cell differentiation(GO:0045577)
0.0	0.1	GO:0043049	otic placode formation(GO:0043049)
0.0	0.0	GO:0046931	pore complex assembly(GO:0046931)
0.0	0.1	GO:0002726	positive regulation of T cell cytokine production(GO:0002726)
0.0	0.1	GO:0046718	viral entry into host cell(GO:0046718)
0.0	0.0	GO:0090218	positive regulation of phosphatidylinositol 3-kinase activity(GO:0043552) positive regulation of lipid kinase activity(GO:0090218)
0.0	0.0	GO:0002085	inhibition of neuroepithelial cell differentiation(GO:0002085)
0.0	0.0	GO:0043951	negative regulation of cAMP-mediated signaling(GO:0043951)
0.0	0.0	GO:0014874	response to stimulus involved in regulation of muscle adaptation(GO:0014874)
0.0	0.0	GO:0055078	sodium ion homeostasis(GO:0055078)
0.0	0.0	GO:0006106	fumarate metabolic process(GO:0006106)
0.0	0.2	GO:0006349	regulation of gene expression by genetic imprinting(GO:0006349)
0.0	0.1	GO:0007210	serotonin receptor signaling pathway(GO:0007210)
0.0	0.1	GO:0042535	positive regulation of tumor necrosis factor biosynthetic process(GO:0042535)
0.0	0.1	GO:0006003	fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0	0.0	GO:0051590	positive regulation of neurotransmitter transport(GO:0051590)
0.0	0.1	GO:0031282	regulation of guanylate cyclase activity(GO:0031282)
0.0	0.0	GO:0046668	regulation of retinal cell programmed cell death(GO:0046668)
0.0	0.0	GO:0002125	maternal aggressive behavior(GO:0002125)
0.0	0.0	GO:0055075	potassium ion homeostasis(GO:0055075)
0.0	0.1	GO:0090286	cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.0	0.0	GO:0033688	regulation of osteoblast proliferation(GO:0033688)
0.0	0.0	GO:0002679	respiratory burst involved in defense response(GO:0002679)
0.0	0.0	GO:0045162	clustering of voltage-gated sodium channels(GO:0045162)
0.0	0.1	GO:0042354	fucose catabolic process(GO:0019317) L-fucose metabolic process(GO:0042354) L-fucose catabolic process(GO:0042355)
0.0	0.0	GO:0071921	establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
0.0	0.1	GO:0007023	post-chaperonin tubulin folding pathway(GO:0007023)
0.0	0.1	GO:0006700	C21-steroid hormone biosynthetic process(GO:0006700)
0.0	0.0	GO:0006189	'de novo' IMP biosynthetic process(GO:0006189)
0.0	0.1	GO:0010508	positive regulation of autophagy(GO:0010508)
0.0	0.1	GO:0051491	positive regulation of filopodium assembly(GO:0051491)
0.0	0.1	GO:0042989	sequestering of actin monomers(GO:0042989)
0.0	0.0	GO:0009415	response to water deprivation(GO:0009414) response to water(GO:0009415)
0.0	0.1	GO:0043388	positive regulation of DNA binding(GO:0043388)
0.0	0.0	GO:0046881	positive regulation of gonadotropin secretion(GO:0032278) positive regulation of follicle-stimulating hormone secretion(GO:0046881)
0.0	0.0	GO:0002282	microglial cell activation involved in immune response(GO:0002282)
0.0	0.1	GO:0022617	extracellular matrix disassembly(GO:0022617)
0.0	0.1	GO:0031274	pseudopodium assembly(GO:0031269) regulation of pseudopodium assembly(GO:0031272) positive regulation of pseudopodium assembly(GO:0031274)
0.0	0.0	GO:0010966	regulation of phosphate transport(GO:0010966)
0.0	0.1	GO:0050930	induction of positive chemotaxis(GO:0050930)
0.0	0.0	GO:0044650	virion attachment to host cell(GO:0019062) adhesion of symbiont to host cell(GO:0044650)
0.0	0.0	GO:0032714	negative regulation of interleukin-5 production(GO:0032714)
0.0	0.0	GO:0060708	spongiotrophoblast differentiation(GO:0060708)
0.0	0.2	GO:0010226	response to lithium ion(GO:0010226)
0.0	0.0	GO:0033152	immunoglobulin V(D)J recombination(GO:0033152)
0.0	0.0	GO:0060218	hematopoietic stem cell differentiation(GO:0060218)
0.0	0.0	GO:0009151	purine deoxyribonucleotide metabolic process(GO:0009151) purine deoxyribonucleoside triphosphate metabolic process(GO:0009215)
0.0	0.2	GO:0045576	mast cell activation(GO:0045576)
0.0	0.0	GO:0006434	seryl-tRNA aminoacylation(GO:0006434)
0.0	0.0	GO:0034219	carbohydrate transmembrane transport(GO:0034219)
0.0	0.0	GO:0001574	ganglioside biosynthetic process(GO:0001574)
0.0	0.0	GO:2000095	regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000095)
0.0	0.0	GO:0061687	detoxification of inorganic compound(GO:0061687) stress response to metal ion(GO:0097501)
0.0	0.1	GO:0048679	regulation of axon regeneration(GO:0048679) regulation of neuron projection regeneration(GO:0070570)
0.0	0.0	GO:0042518	negative regulation of tyrosine phosphorylation of Stat3 protein(GO:0042518)
0.0	0.0	GO:0045821	positive regulation of nucleotide catabolic process(GO:0030813) positive regulation of glycolytic process(GO:0045821) positive regulation of nucleoside metabolic process(GO:0045979) positive regulation of cofactor metabolic process(GO:0051194) positive regulation of coenzyme metabolic process(GO:0051197) positive regulation of ATP metabolic process(GO:1903580)
0.0	0.0	GO:0045425	positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process(GO:0045425)
0.0	0.0	GO:0070779	D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0	0.1	GO:0002634	regulation of germinal center formation(GO:0002634)
0.0	0.0	GO:0009299	mRNA transcription(GO:0009299)
0.0	0.0	GO:0070857	regulation of bile acid biosynthetic process(GO:0070857) regulation of bile acid metabolic process(GO:1904251)
0.0	0.3	GO:0050690	regulation of defense response to virus by virus(GO:0050690)
0.0	0.0	GO:0006089	lactate metabolic process(GO:0006089)
0.0	0.0	GO:0032495	response to muramyl dipeptide(GO:0032495)
0.0	0.0	GO:0021860	pyramidal neuron differentiation(GO:0021859) pyramidal neuron development(GO:0021860)
0.0	0.0	GO:0071318	cellular response to ATP(GO:0071318)
0.0	0.1	GO:0006991	response to sterol depletion(GO:0006991)
0.0	0.0	GO:0071392	cellular response to estradiol stimulus(GO:0071392)
0.0	0.0	GO:0014029	neural crest formation(GO:0014029) neural crest cell fate commitment(GO:0014034)
0.0	0.0	GO:0031057	negative regulation of histone modification(GO:0031057)
0.0	0.0	GO:0010614	negative regulation of cardiac muscle hypertrophy(GO:0010614)
0.0	0.1	GO:2000272	negative regulation of receptor activity(GO:2000272)
0.0	0.2	GO:0005980	glycogen catabolic process(GO:0005980)
0.0	0.0	GO:0045650	negative regulation of macrophage differentiation(GO:0045650)
0.0	0.0	GO:0030260	entry into host cell(GO:0030260) entry into host(GO:0044409) entry into cell of other organism involved in symbiotic interaction(GO:0051806) entry into other organism involved in symbiotic interaction(GO:0051828)
0.0	0.0	GO:0060913	cardiac cell fate determination(GO:0060913)
0.0	0.1	GO:0016577	histone demethylation(GO:0016577)
0.0	0.0	GO:0060004	reflex(GO:0060004)
0.0	0.0	GO:0043490	malate-aspartate shuttle(GO:0043490)
0.0	0.0	GO:0002032	desensitization of G-protein coupled receptor protein signaling pathway by arrestin(GO:0002032)
0.0	0.0	GO:0002025	vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure(GO:0002025)
0.0	0.0	GO:0031536	positive regulation of exit from mitosis(GO:0031536)
0.0	0.0	GO:1903332	regulation of protein folding(GO:1903332)
0.0	0.0	GO:0030854	positive regulation of granulocyte differentiation(GO:0030854)
0.0	0.0	GO:0051451	myoblast migration(GO:0051451)
0.0	0.0	GO:0010739	positive regulation of protein kinase A signaling(GO:0010739)

Gene overrepresentation in cellular component category:

Total log-likelihood	Term	Description
0.1	GO:0070022	transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.1	GO:0031235	intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.2	GO:0001891	phagocytic cup(GO:0001891)
0.1	GO:0043259	laminin-10 complex(GO:0043259)
0.2	GO:0098984	asymmetric synapse(GO:0032279) neuron to neuron synapse(GO:0098984)
0.1	GO:0031088	platelet dense granule membrane(GO:0031088)
0.2	GO:0042101	T cell receptor complex(GO:0042101)
0.2	GO:0032391	photoreceptor connecting cilium(GO:0032391)
0.1	GO:0030121	AP-1 adaptor complex(GO:0030121)
0.0	GO:0031931	TORC1 complex(GO:0031931)
0.1	GO:0034045	pre-autophagosomal structure membrane(GO:0034045)
0.0	GO:0033150	cytoskeletal calyx(GO:0033150)
0.1	GO:0031362	anchored component of external side of plasma membrane(GO:0031362)
0.0	GO:0000214	tRNA-intron endonuclease complex(GO:0000214)
0.1	GO:0090533	cation-transporting ATPase complex(GO:0090533)
0.1	GO:0034993	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0	GO:0032133	chromosome passenger complex(GO:0032133)
0.0	GO:0014731	spectrin-associated cytoskeleton(GO:0014731)
0.1	GO:0034451	centriolar satellite(GO:0034451)
0.1	GO:0000300	obsolete peripheral to membrane of membrane fraction(GO:0000300)
0.1	GO:0005797	Golgi medial cisterna(GO:0005797)
0.0	GO:0005954	calcium- and calmodulin-dependent protein kinase complex(GO:0005954)
0.2	GO:0005665	DNA-directed RNA polymerase II, core complex(GO:0005665)
0.1	GO:0019908	nuclear cyclin-dependent protein kinase holoenzyme complex(GO:0019908)
0.2	GO:0005669	transcription factor TFIID complex(GO:0005669)
0.0	GO:0005827	polar microtubule(GO:0005827)
0.0	GO:0005638	lamin filament(GO:0005638)
0.0	GO:0042622	photoreceptor outer segment membrane(GO:0042622)
0.1	GO:0044224	juxtaparanode region of axon(GO:0044224)
0.1	GO:0072357	PTW/PP1 phosphatase complex(GO:0072357)
0.1	GO:0008290	F-actin capping protein complex(GO:0008290)
0.1	GO:0000307	cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1	GO:0000805	X chromosome(GO:0000805)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0005275	amine transmembrane transporter activity(GO:0005275)
0.1	0.2	GO:0004999	vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.1	0.2	GO:0016312	inositol bisphosphate phosphatase activity(GO:0016312)
0.1	0.2	GO:0035184	histone threonine kinase activity(GO:0035184)
0.0	0.2	GO:0004111	creatine kinase activity(GO:0004111)
0.0	0.1	GO:0008474	palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0	0.1	GO:0052834	inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate phosphatase activity(GO:0052834)
0.0	0.1	GO:0008184	glycogen phosphorylase activity(GO:0008184)
0.0	0.1	GO:0050508	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.0	0.2	GO:0004706	JUN kinase kinase kinase activity(GO:0004706)
0.0	0.2	GO:0030618	transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0	0.1	GO:0033691	sialic acid binding(GO:0033691)
0.0	0.1	GO:0047238	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.0	0.2	GO:0001609	G-protein coupled adenosine receptor activity(GO:0001609)
0.0	0.1	GO:0003701	obsolete RNA polymerase I transcription factor activity(GO:0003701)
0.0	0.1	GO:0000268	peroxisome targeting sequence binding(GO:0000268)
0.0	0.1	GO:0061731	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.0	0.1	GO:0017089	glycolipid transporter activity(GO:0017089)
0.0	0.2	GO:0050700	CARD domain binding(GO:0050700)
0.0	0.1	GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.0	0.1	GO:0030023	extracellular matrix constituent conferring elasticity(GO:0030023) structural molecule activity conferring elasticity(GO:0097493)
0.0	0.1	GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.0	0.2	GO:0035251	UDP-glucosyltransferase activity(GO:0035251)
0.0	0.0	GO:0032139	dinucleotide insertion or deletion binding(GO:0032139)
0.0	0.2	GO:0017080	sodium channel regulator activity(GO:0017080)
0.0	0.1	GO:0030368	interleukin-17 receptor activity(GO:0030368)
0.0	0.1	GO:0004911	interleukin-2 receptor activity(GO:0004911)
0.0	0.1	GO:0004465	lipoprotein lipase activity(GO:0004465)
0.0	0.1	GO:0030306	ADP-ribosylation factor binding(GO:0030306)
0.0	0.1	GO:0004117	calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117)
0.0	0.1	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0	0.1	GO:0004331	fructose-2,6-bisphosphate 2-phosphatase activity(GO:0004331)
0.0	0.2	GO:0016493	C-C chemokine receptor activity(GO:0016493)
0.0	0.1	GO:0004563	beta-N-acetylhexosaminidase activity(GO:0004563)
0.0	0.1	GO:0005025	transforming growth factor beta receptor activity, type I(GO:0005025)
0.0	0.1	GO:0047894	flavonol 3-sulfotransferase activity(GO:0047894)
0.0	0.1	GO:0050431	transforming growth factor beta binding(GO:0050431)
0.0	0.3	GO:0005086	ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0	0.2	GO:0005251	delayed rectifier potassium channel activity(GO:0005251)
0.0	0.3	GO:0004012	phospholipid-translocating ATPase activity(GO:0004012)
0.0	0.1	GO:0004719	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.0	0.1	GO:0046920	alpha-(1->3)-fucosyltransferase activity(GO:0046920)
0.0	0.1	GO:0070735	protein-glycine ligase activity(GO:0070735)
0.0	0.0	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0	0.0	GO:0004052	arachidonate 12-lipoxygenase activity(GO:0004052)
0.0	0.0	GO:0043533	inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.0	0.2	GO:0008353	RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.0	0.1	GO:0031821	G-protein coupled serotonin receptor binding(GO:0031821)
0.0	0.1	GO:0070053	thrombospondin receptor activity(GO:0070053)
0.0	0.0	GO:0045159	myosin II binding(GO:0045159)
0.0	0.1	GO:0008020	G-protein coupled photoreceptor activity(GO:0008020)
0.0	0.0	GO:0004873	asialoglycoprotein receptor activity(GO:0004873)
0.0	0.0	GO:0032137	guanine/thymine mispair binding(GO:0032137)
0.0	0.1	GO:0015421	oligopeptide-transporting ATPase activity(GO:0015421)
0.0	0.0	GO:0008821	crossover junction endodeoxyribonuclease activity(GO:0008821)
0.0	0.1	GO:0052650	NADP-retinol dehydrogenase activity(GO:0052650)
0.0	0.4	GO:0003823	antigen binding(GO:0003823)
0.0	0.1	GO:0043425	bHLH transcription factor binding(GO:0043425)
0.0	0.0	GO:0000400	four-way junction DNA binding(GO:0000400)
0.0	0.1	GO:0001085	RNA polymerase II transcription factor binding(GO:0001085)
0.0	0.0	GO:0004449	isocitrate dehydrogenase (NAD+) activity(GO:0004449)
0.0	0.0	GO:0019863	IgE binding(GO:0019863)
0.0	0.0	GO:0019870	potassium channel inhibitor activity(GO:0019870)
0.0	0.0	GO:0004142	diacylglycerol cholinephosphotransferase activity(GO:0004142)
0.0	0.0	GO:0043398	HLH domain binding(GO:0043398)
0.0	0.1	GO:0005087	Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.0	0.0	GO:0004505	phenylalanine 4-monooxygenase activity(GO:0004505)
0.0	0.0	GO:0004966	galanin receptor activity(GO:0004966)
0.0	0.1	GO:0004957	prostaglandin E receptor activity(GO:0004957)
0.0	0.2	GO:0005527	macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0	0.1	GO:0099604	calcium-release channel activity(GO:0015278) ligand-gated calcium channel activity(GO:0099604)
0.0	0.0	GO:0015183	L-aspartate transmembrane transporter activity(GO:0015183)
0.0	0.1	GO:0008273	calcium, potassium:sodium antiporter activity(GO:0008273)
0.0	0.1	GO:0016986	obsolete transcription initiation factor activity(GO:0016986)
0.0	0.0	GO:0004965	G-protein coupled GABA receptor activity(GO:0004965)
0.0	0.0	GO:0004828	serine-tRNA ligase activity(GO:0004828)
0.0	0.2	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0	0.0	GO:0008140	cAMP response element binding protein binding(GO:0008140)
0.0	0.1	GO:0004969	histamine receptor activity(GO:0004969)
0.0	0.0	GO:0032036	myosin heavy chain binding(GO:0032036)
0.0	0.0	GO:0015252	hydrogen ion channel activity(GO:0015252)
0.0	0.2	GO:0005545	1-phosphatidylinositol binding(GO:0005545)
0.0	0.1	GO:0004791	thioredoxin-disulfide reductase activity(GO:0004791)
0.0	0.0	GO:0017159	pantetheine hydrolase activity(GO:0017159)
0.0	0.0	GO:0016361	activin receptor activity, type I(GO:0016361)
0.0	0.0	GO:0004800	thyroxine 5'-deiodinase activity(GO:0004800)
0.0	0.1	GO:0015165	pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.0	0.1	GO:0009008	DNA-methyltransferase activity(GO:0009008)
0.0	0.1	GO:0004703	G-protein coupled receptor kinase activity(GO:0004703)
0.0	0.0	GO:0051733	ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734)
0.0	0.1	GO:0005031	tumor necrosis factor-activated receptor activity(GO:0005031)
0.0	0.0	GO:0016309	1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0	0.1	GO:0008499	UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity(GO:0008499)
0.0	0.1	GO:0008266	poly(U) RNA binding(GO:0008266)
0.0	0.0	GO:0030197	extracellular matrix constituent, lubricant activity(GO:0030197)
0.0	0.1	GO:0001786	phosphatidylserine binding(GO:0001786)
0.0	0.0	GO:0030292	protein tyrosine kinase inhibitor activity(GO:0030292)
0.0	0.0	GO:0031957	very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0	0.0	GO:0019788	NEDD8 transferase activity(GO:0019788)
0.0	0.0	GO:0019855	calcium channel inhibitor activity(GO:0019855)
0.0	0.0	GO:0004939	beta-adrenergic receptor activity(GO:0004939)
0.0	0.1	GO:0004767	sphingomyelin phosphodiesterase activity(GO:0004767)
0.0	0.1	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.0	0.5	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)
0.0	0.1	GO:0031701	angiotensin receptor binding(GO:0031701)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
1.0	PID CD8 TCR PATHWAY	TCR signaling in naïve CD8+ T cells
0.4	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
0.0	PID PDGFRA PATHWAY	PDGFR-alpha signaling pathway
0.0	SA B CELL RECEPTOR COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.1	PID S1P S1P4 PATHWAY	S1P4 pathway
0.6	PID TGFBR PATHWAY	TGF-beta receptor signaling
0.4	ST JNK MAPK PATHWAY	JNK MAPK Pathway
0.2	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
0.3	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.3	SIG PIP3 SIGNALING IN B LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.0	REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE	Genes involved in Translocation of ZAP-70 to Immunological synapse
0.2	REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION	Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.3	REACTOME ENOS ACTIVATION AND REGULATION	Genes involved in eNOS activation and regulation
0.3	REACTOME SIGNALING BY NODAL	Genes involved in Signaling by NODAL
0.0	REACTOME TRAF6 MEDIATED NFKB ACTIVATION	Genes involved in TRAF6 mediated NF-kB activation
0.5	REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.2	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.0	REACTOME SIGNALING BY NOTCH4	Genes involved in Signaling by NOTCH4
0.2	REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS	Genes involved in Glycogen breakdown (glycogenolysis)
0.1	REACTOME PROSTANOID LIGAND RECEPTORS	Genes involved in Prostanoid ligand receptors
0.1	REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES	Genes involved in Recruitment of NuMA to mitotic centrosomes
0.3	REACTOME GPVI MEDIATED ACTIVATION CASCADE	Genes involved in GPVI-mediated activation cascade
0.0	REACTOME REGULATION OF MITOTIC CELL CYCLE	Genes involved in Regulation of mitotic cell cycle
0.2	REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT	Genes involved in Organic cation/anion/zwitterion transport
0.2	REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.1	REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE	Genes involved in Synthesis of PIPs at the late endosome membrane
0.0	REACTOME IMMUNE SYSTEM	Genes involved in Immune System
0.2	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0	REACTOME DSCAM INTERACTIONS	Genes involved in DSCAM interactions
0.1	REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR	Genes involved in Trafficking and processing of endosomal TLR
0.0	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.5	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1	REACTOME ACTIVATION OF RAC	Genes involved in Activation of Rac
0.0	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway