CREMA results: SCRT1

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Transcription factors associated with SCRT1_SCRT2

Gene Symbol	Gene ID	Gene Info
SCRT1 Ensembl NCBI GeneCards UniProt	ENSG00000170616.9	scratch family transcriptional repressor 1
SCRT2 Ensembl NCBI GeneCards UniProt	ENSG00000215397.3	scratch family transcriptional repressor 2

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

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CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
chr20_656821_656972	SCRT2	73	0.866781	-0.22	5.8e-01	Click!
chr20_657228_657379	SCRT2	480	0.629237	0.15	7.0e-01	Click!
chr20_680713_680864	SCRT2	23965	0.150743	-0.48	1.9e-01	Click!
chr20_682209_682360	SCRT2	25461	0.148482	-0.32	4.1e-01	Click!
chr20_684137_684288	SCRT2	27389	0.145446	-0.63	7.1e-02	Click!
chr8_145555253_145555567	SCRT1	4533	0.082086	0.38	3.2e-01	Click!
chr8_145555628_145555779	SCRT1	4240	0.084133	0.55	1.3e-01	Click!
chr8_145558373_145558524	SCRT1	1495	0.180572	-0.49	1.8e-01	Click!
chr8_145559016_145559167	SCRT1	852	0.340036	0.36	3.5e-01	Click!
chr8_145561150_145561433	SCRT1	1348	0.201225	0.30	4.3e-01	Click!

Showing 1 to 10 of 10 entries

Activity of the SCRT1_SCRT2 motif across conditions

Conditions sorted by the z-value of the SCRT1_SCRT2 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

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Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr18_2950342_2950493	0.89	RP11-737O24.2		2078	0.26
chr1_111436407_111436686	0.84	CD53	CD53 molecule	20770	0.16
chr2_34257_34408	0.77	FAM110C	family with sequence similarity 110, member C	12053	0.3
chr8_10905444_10905762	0.74	ENSG00000207600	.	12791	0.17
chr13_28002327_28002478	0.74	GTF3A	general transcription factor IIIA	1693	0.33
chr5_169762940_169763200	0.72	KCNIP1	Kv channel interacting protein 1	17421	0.18
chr20_3795874_3796116	0.70	AP5S1	adaptor-related protein complex 5, sigma 1 subunit	5183	0.13
chr11_128495747_128495961	0.68	ETS1	v-ets avian erythroblastosis virus E26 oncogene homolog 1	38401	0.15
chr2_42523029_42523463	0.66	EML4	echinoderm microtubule associated protein like 4	5147	0.28
chr7_99820202_99820353	0.66	ENSG00000222482	.	2534	0.13

Showing 1 to 10 of 200 entries

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of SCRT1_SCRT2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.7	GO:0008360	regulation of cell shape(GO:0008360)
0.1	0.5	GO:0045793	positive regulation of cell size(GO:0045793)
0.1	0.5	GO:0006554	lysine metabolic process(GO:0006553) lysine catabolic process(GO:0006554)
0.0	0.5	GO:0045086	positive regulation of interleukin-2 biosynthetic process(GO:0045086)
0.0	0.5	GO:0021516	dorsal spinal cord development(GO:0021516)
0.0	0.5	GO:0035336	long-chain fatty-acyl-CoA metabolic process(GO:0035336) long-chain fatty-acyl-CoA biosynthetic process(GO:0035338)
0.0	0.5	GO:0050852	T cell receptor signaling pathway(GO:0050852)
0.0	0.5	GO:0006521	regulation of cellular amino acid metabolic process(GO:0006521)
0.1	0.4	GO:0045759	negative regulation of action potential(GO:0045759)
0.1	0.3	GO:0050862	positive regulation of T cell receptor signaling pathway(GO:0050862)

Showing 1 to 10 of 222 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.6	GO:0005845	mRNA cap binding complex(GO:0005845) RNA cap binding complex(GO:0034518)
0.0	0.6	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0	0.5	GO:0005778	peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0	0.4	GO:0042101	T cell receptor complex(GO:0042101)
0.0	0.4	GO:0005881	cytoplasmic microtubule(GO:0005881)
0.1	0.3	GO:0070937	CRD-mediated mRNA stability complex(GO:0070937)
0.0	0.3	GO:0000242	pericentriolar material(GO:0000242)
0.0	0.3	GO:0030175	filopodium(GO:0030175)
0.0	0.2	GO:0031312	extrinsic component of organelle membrane(GO:0031312)
0.0	0.2	GO:0001891	phagocytic cup(GO:0001891)

Showing 1 to 10 of 59 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.9	GO:0003743	translation initiation factor activity(GO:0003743)
0.1	0.6	GO:0004467	long-chain fatty acid-CoA ligase activity(GO:0004467)
0.0	0.6	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)
0.2	0.5	GO:0004591	oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.0	0.5	GO:0005095	GTPase inhibitor activity(GO:0005095)
0.0	0.5	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.1	0.4	GO:0004949	cannabinoid receptor activity(GO:0004949)
0.1	0.3	GO:0050693	LBD domain binding(GO:0050693)
0.1	0.3	GO:0005087	Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.0	0.3	GO:0004439	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity(GO:0004439)

Showing 1 to 10 of 148 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Total log-likelihood	Term	Description
1.6	PID CD8 TCR PATHWAY	TCR signaling in naïve CD8+ T cells
0.9	PID MET PATHWAY	Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.6	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.5	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
0.5	PID P38 MKK3 6PATHWAY	p38 MAPK signaling pathway
0.5	ST PHOSPHOINOSITIDE 3 KINASE PATHWAY	PI3K Pathway
0.5	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.4	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
0.4	PID ERBB1 INTERNALIZATION PATHWAY	Internalization of ErbB1
0.4	PID LKB1 PATHWAY	LKB1 signaling events

Showing 1 to 10 of 31 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Total log-likelihood	Term	Description
0.8	REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES	Genes involved in Antiviral mechanism by IFN-stimulated genes
0.7	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
0.6	REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS	Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.6	REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1	Genes involved in Autodegradation of the E3 ubiquitin ligase COP1
0.5	REACTOME CITRIC ACID CYCLE TCA CYCLE	Genes involved in Citric acid cycle (TCA cycle)
0.5	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
0.5	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.5	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.4	REACTOME PECAM1 INTERACTIONS	Genes involved in PECAM1 interactions
0.4	REACTOME IL 2 SIGNALING	Genes involved in Interleukin-2 signaling

Showing 1 to 10 of 47 entries

Results for SCRT1_SCRT2

Z-value: 1.69

Motif logo

Transcription factors associated with SCRT1_SCRT2

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Activity of the SCRT1_SCRT2 motif across conditions

Conditions sorted by the z-value of the SCRT1_SCRT2 motif activity

Top target CREs of the motif:

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of SCRT1_SCRT2

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: