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ENCODE: H3K4me1 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for SIN3A_CHD1

Z-value: 1.02

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Transcription factors associated with SIN3A_CHD1

Gene Symbol	Gene ID	Gene Info
SIN3A Ensembl NCBI GeneCards UniProt	ENSG00000169375.11	SIN3A
CHD1 Ensembl NCBI GeneCards UniProt	ENSG00000153922.6	CHD1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
CHD1	chr5_98251278_98251429	10887	0.202299	0.74	2.4e-02	Click!
CHD1	chr5_98254524_98254675	7641	0.212608	0.67	4.8e-02	Click!
CHD1	chr5_98262951_98263102	786	0.672821	-0.65	5.9e-02	Click!
CHD1	chr5_98247552_98247756	14586	0.193643	0.60	8.4e-02	Click!
CHD1	chr5_98250243_98250394	11922	0.199749	0.54	1.4e-01	Click!
SIN3A	chr15_75761109_75761260	13001	0.173450	0.78	1.2e-02	Click!
SIN3A	chr15_75744674_75744875	687	0.684485	-0.61	7.9e-02	Click!
SIN3A	chr15_75724560_75724777	19258	0.152248	0.61	8.3e-02	Click!
SIN3A	chr15_75719269_75719420	24582	0.138895	-0.56	1.2e-01	Click!
SIN3A	chr15_75761353_75761612	13299	0.172845	0.53	1.4e-01	Click!

Activity of the SIN3A_CHD1 motif across conditions

Conditions sorted by the z-value of the SIN3A_CHD1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr9_69786015_69786709	1.34	IGKV1OR-2	immunoglobulin kappa variable 1/OR-2 (pseudogene)	8409	0.25
chr17_1132183_1132576	0.55	ABR	active BCR-related	81	0.97
chr1_220863452_220864325	0.50	C1orf115	chromosome 1 open reading frame 115	701	0.71
chr16_49315668_49315968	0.50	CBLN1	cerebellin 1 precursor	76	0.98
chr8_140716343_140716851	0.47	KCNK9	potassium channel, subfamily K, member 9	1298	0.63
chr6_1611321_1611696	0.47	FOXC1	forkhead box C1	827	0.76
chr4_170192393_170192771	0.46	SH3RF1	SH3 domain containing ring finger 1	326	0.93
chr1_1475615_1475901	0.46	TMEM240	transmembrane protein 240	21	0.96
chrX_68724102_68724531	0.42	ENSG00000264604	.	232	0.85
chrX_153095505_153095958	0.41	PDZD4	PDZ domain containing 4	82	0.94
chr19_14168091_14168390	0.40	PALM3	paralemmin 3	171	0.89
chr2_42795325_42795726	0.39	MTA3	metastasis associated 1 family, member 3	132	0.97
chr5_175299080_175299718	0.39	CPLX2	complexin 2	414	0.87
chr2_176972649_176972909	0.39	ENSG00000216193	.	592	0.39
chr1_38511967_38512267	0.38	POU3F1	POU class 3 homeobox 1	333	0.86
chr7_128431078_128431544	0.37	CCDC136	coiled-coil domain containing 136	153	0.93
chr7_145812958_145813349	0.37	CNTNAP2	contactin associated protein-like 2	300	0.93
chr8_81477973_81478412	0.37	ENSG00000223327	.	19816	0.2
chr19_52192320_52192671	0.36	ENSG00000207550	.	3370	0.12
chr7_129419053_129419592	0.36	ENSG00000207691	.	4468	0.17
chr19_1513130_1513873	0.35	ADAMTSL5	ADAMTS-like 5	313	0.73
chr1_41130861_41131209	0.35	RIMS3	regulating synaptic membrane exocytosis 3	82	0.97
chr17_71641352_71641596	0.35	SDK2	sidekick cell adhesion molecule 2	1246	0.51
chr6_1611903_1612454	0.35	FOXC1	forkhead box C1	1497	0.56
chr19_1164693_1164844	0.34	SBNO2	strawberry notch homolog 2 (Drosophila)	4174	0.14
chr19_15491045_15491543	0.34	AKAP8	A kinase (PRKA) anchor protein 8	691	0.51
chr10_81206187_81206604	0.34	ZCCHC24	zinc finger, CCHC domain containing 24	1012	0.58
chr12_662501_663191	0.32	B4GALNT3	beta-1,4-N-acetyl-galactosaminyl transferase 3	10547	0.16
chr9_103235830_103236309	0.32	TMEFF1	transmembrane protein with EGF-like and two follistatin-like domains 1	674	0.71
chr7_1704828_1705261	0.31	ELFN1	extracellular leucine-rich repeat and fibronectin type III domain containing 1	22711	0.17
chr8_145012318_145012709	0.30	PLEC	plectin	1245	0.31
chr17_37729625_37730222	0.30	ENSG00000222777	.	27426	0.12
chr9_14315059_14315375	0.29	NFIB	nuclear factor I/B	636	0.73
chr14_24837858_24838637	0.29	NFATC4	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4	41	0.94
chr19_8260319_8260582	0.29	CERS4	ceramide synthase 4	11170	0.16
chr1_895413_895840	0.29	KLHL17	kelch-like family member 17	341	0.68
chr6_41993885_41994069	0.29	ENSG00000206875	.	7725	0.16
chr17_33787552_33787703	0.29	SLFN13	schlafen family member 13	11771	0.12
chr19_7989733_7990535	0.27	CTD-3193O13.8		752	0.29
chr8_144955877_144956171	0.27	EPPK1	epiplakin 1	3392	0.13
chr17_76875045_76875748	0.27	TIMP2	TIMP metallopeptidase inhibitor 2	5164	0.16
chr14_56683953_56684174	0.27	PELI2	pellino E3 ubiquitin protein ligase family member 2	98236	0.08
chr12_80083776_80084245	0.27	PAWR	PRKC, apoptosis, WT1, regulator	150	0.97
chr2_43361384_43361969	0.26	ENSG00000207087	.	43044	0.18
chr3_137490047_137490281	0.26	SOX14	SRY (sex determining region Y)-box 14	6585	0.32
chr6_35181746_35182466	0.26	SCUBE3	signal peptide, CUB domain, EGF-like 3	84	0.97
chr22_39417441_39417875	0.26	APOBEC3D	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D	201	0.89
chr18_76740387_76741175	0.26	SALL3	spalt-like transcription factor 3	506	0.87
chr5_79365725_79365962	0.26	CTD-2201I18.1		12384	0.2
chr17_80398931_80399097	0.26	C17orf62	chromosome 17 open reading frame 62	3390	0.11
chr14_103986978_103987655	0.26	CKB	creatine kinase, brain	122	0.92
chrX_135849318_135849469	0.25	ARHGEF6	Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6	109	0.97
chr6_43738525_43738880	0.25	VEGFA	vascular endothelial growth factor A	118	0.78
chr2_219846310_219846631	0.25	FEV	FEV (ETS oncogene family)	3909	0.11
chr19_709223_709862	0.25	PALM	paralemmin	441	0.7
chr21_37502666_37502817	0.25	AP000688.14		3803	0.15
chr17_1613463_1614162	0.25	TLCD2	TLC domain containing 2	80	0.94
chr4_2061713_2062092	0.25	NAT8L	N-acetyltransferase 8-like (GCN5-related, putative)	363	0.84
chr2_135018956_135019266	0.24	MGAT5	mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase	7281	0.27
chr2_63281096_63281304	0.24	OTX1	orthodenticle homeobox 1	3263	0.29
chr14_65213142_65213375	0.24	PLEKHG3	pleckstrin homology domain containing, family G (with RhoGef domain) member 3	8505	0.21
chrX_53349333_53349573	0.24	IQSEC2	IQ motif and Sec7 domain 2	1069	0.48
chr11_48002134_48002405	0.24	PTPRJ	protein tyrosine phosphatase, receptor type, J	10	0.98
chr1_9303878_9304029	0.24	H6PD	hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)	4050	0.23
chr1_47904813_47905194	0.24	FOXD2	forkhead box D2	3314	0.19
chr1_2986226_2986879	0.23	PRDM16	PR domain containing 16	777	0.57
chr16_87022731_87022882	0.23	RP11-899L11.3		226715	0.02
chr2_175869706_175870142	0.23	CHN1	chimerin 1	30	0.97
chr6_138752539_138752911	0.23	ENSG00000266555	.	3706	0.25
chr7_139960445_139960596	0.23	ENSG00000199283	.	18850	0.17
chr2_239139883_239140304	0.23	AC016757.3	Protein LOC151174	21	0.75
chr1_148854904_148855383	0.23	ENSG00000222854	.	58239	0.13
chr2_25143411_25143810	0.23	ADCY3	adenylate cyclase 3	902	0.57
chr11_118016566_118017132	0.23	SCN4B	sodium channel, voltage-gated, type IV, beta subunit	6686	0.16
chr20_821989_822287	0.23	FAM110A	family with sequence similarity 110, member A	3147	0.3
chr5_76925321_76925875	0.23	WDR41	WD repeat domain 41	9162	0.23
chr3_13045853_13046441	0.22	IQSEC1	IQ motif and Sec7 domain 1	17611	0.25
chr11_118767424_118768222	0.22	RP11-158I9.5		9372	0.09
chr1_9790555_9790706	0.22	PIK3CD	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta	12503	0.17
chr17_77788487_77789261	0.22	ENSG00000238331	.	4396	0.16
chr2_10417901_10418493	0.22	ENSG00000264030	.	2560	0.25
chr2_241375193_241375732	0.22	GPC1	glypican 1	374	0.85
chr2_179059335_179059702	0.22	OSBPL6	oxysterol binding protein-like 6	142	0.97
chr16_4366412_4367009	0.22	GLIS2	GLIS family zinc finger 2	1948	0.24
chr12_1640143_1640389	0.21	WNT5B	wingless-type MMTV integration site family, member 5B	281	0.93
chr1_147072101_147072252	0.21	ACP6	acid phosphatase 6, lysophosphatidic	58940	0.12
chr2_148602775_148603076	0.21	ACVR2A	activin A receptor, type IIA	740	0.7
chr17_42198349_42198622	0.21	HDAC5	histone deacetylase 5	2158	0.16
chrX_57021806_57021957	0.21	SPIN3	spindlin family, member 3	88	0.98
chr15_65067250_65067549	0.21	RBPMS2	RNA binding protein with multiple splicing 2	387	0.8
chr10_134755869_134756456	0.21	TTC40	tetratricopeptide repeat domain 40	73	0.98
chr18_10454407_10454669	0.21	APCDD1	adenomatosis polyposis coli down-regulated 1	87	0.98
chr8_95653134_95653505	0.21	ESRP1	epithelial splicing regulatory protein 1	17	0.97
chr17_1388316_1388880	0.21	MYO1C	myosin IC	63	0.96
chr15_56035205_56035434	0.21	PRTG	protogenin	31	0.98
chr16_54319563_54320025	0.20	IRX3	iroquois homeobox 3	27	0.98
chr13_114898126_114898522	0.20	RASA3	RAS p21 protein activator 3	238	0.94
chr3_133614378_133614535	0.20	RAB6B	RAB6B, member RAS oncogene family	17	0.98
chr2_112896432_112896734	0.20	FBLN7	fibulin 7	423	0.88
chr19_3950919_3951410	0.20	DAPK3	death-associated protein kinase 3	9993	0.1
chr7_64786949_64787100	0.20	ENSG00000252102	.	4608	0.21
chr16_89149708_89149925	0.20	ACSF3	acyl-CoA synthetase family member 3	4967	0.19
chr16_28073787_28074211	0.20	GSG1L	GSG1-like	823	0.66
chr10_135043950_135044439	0.20	UTF1	undifferentiated embryonic cell transcription factor 1	416	0.76
chr8_23260829_23261542	0.20	LOXL2	lysyl oxidase-like 2	404	0.85
chr6_43243469_43244256	0.20	SLC22A7	solute carrier family 22 (organic anion transporter), member 7	21874	0.11
chr8_144976584_144976776	0.20	EPPK1	epiplakin 1	24048	0.09
chr16_14396181_14396446	0.19	ENSG00000207639	.	1511	0.39
chr19_7723026_7723421	0.19	RETN	resistin	10707	0.07
chr19_49250260_49250724	0.19	IZUMO1	izumo sperm-egg fusion 1	326	0.76
chr8_144513420_144513883	0.19	MAFA	v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog A	1075	0.37
chr16_70719204_70719725	0.19	MTSS1L	metastasis suppressor 1-like	505	0.73
chr16_23877021_23877290	0.19	PRKCB	protein kinase C, beta	28611	0.21
chr4_7049798_7050097	0.19	RP11-367J11.2		1989	0.21
chr4_186131098_186131398	0.19	SNX25	sorting nexin 25	15	0.92
chr7_6661507_6661658	0.19	ZNF853	zinc finger protein 853	6334	0.13
chr6_150921076_150921438	0.19	PLEKHG1	pleckstrin homology domain containing, family G (with RhoGef domain) member 1	238	0.82
chr11_46326677_46326971	0.19	CREB3L1	cAMP responsive element binding protein 3-like 1	5884	0.18
chr19_7734010_7734283	0.19	RETN	resistin	67	0.93
chr11_279490_280193	0.18	NLRP6	NLR family, pyrin domain containing 6	1271	0.22
chr22_39323300_39323451	0.18	APOBEC3A	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A	25381	0.12
chr2_121100177_121100328	0.18	INHBB	inhibin, beta B	3467	0.32
chr17_36508561_36508839	0.18	SOCS7	suppressor of cytokine signaling 7	126	0.95
chr19_42828405_42828656	0.18	MEGF8	multiple EGF-like-domains 8	1231	0.29
chr10_83633826_83633977	0.18	NRG3	neuregulin 3	1169	0.66
chr19_42419984_42420278	0.18	CTD-2575K13.6		5882	0.13
chr12_113623598_113623967	0.18	RITA1	RBPJ interacting and tubulin associated 1	435	0.46
chr8_101803753_101803904	0.18	ENSG00000202001	.	36405	0.12
chr8_136683849_136684000	0.18	ENSG00000199652	.	70814	0.13
chr7_2672947_2673687	0.18	TTYH3	tweety family member 3	1527	0.39
chr19_1651787_1652144	0.18	TCF3	transcription factor 3	361	0.81
chr11_70049554_70049852	0.18	FADD	Fas (TNFRSF6)-associated via death domain	434	0.77
chr15_100881699_100882205	0.18	ADAMTS17	ADAM metallopeptidase with thrombospondin type 1 motif, 17	258	0.94
chr19_13050056_13050207	0.18	CALR	calreticulin	672	0.39
chr1_53528255_53528820	0.18	PODN	podocan	652	0.65
chr15_65204064_65204408	0.18	ANKDD1A	ankyrin repeat and death domain containing 1A	116	0.96
chr18_53954362_53954513	0.18	ENSG00000201816	.	207612	0.03
chr21_34863671_34863822	0.18	DNAJC28	DnaJ (Hsp40) homolog, subfamily C, member 28	34	0.96
chr3_69246534_69246770	0.18	FRMD4B	FERM domain containing 4B	1769	0.44
chr3_159481915_159482604	0.18	IQCJ-SCHIP1	IQCJ-SCHIP1 readthrough	254	0.92
chr19_30334052_30334510	0.18	CCNE1	cyclin E1	26171	0.23
chr2_176995253_176995433	0.18	HOXD8	homeobox D8	258	0.79
chr2_109827837_109827988	0.18	ENSG00000264934	.	69868	0.11
chr1_63788558_63788978	0.18	FOXD3	forkhead box D3	38	0.89
chr10_21785246_21785539	0.18	ENSG00000222071	.	178	0.86
chr16_31094623_31094782	0.18	PRSS53	protease, serine, 53	5582	0.07
chr8_145115066_145115529	0.17	OPLAH	5-oxoprolinase (ATP-hydrolysing)	287	0.77
chr2_287605_287899	0.17	FAM150B	family with sequence similarity 150, member B	65	0.95
chr5_14144859_14145160	0.17	TRIO	trio Rho guanine nucleotide exchange factor	1180	0.66
chr7_104987897_104988048	0.17	ENSG00000201179	.	14735	0.21
chr8_61689037_61689188	0.17	RP11-33I11.2		33053	0.2
chr1_17922092_17922243	0.17	ARHGEF10L	Rho guanine nucleotide exchange factor (GEF) 10-like	7256	0.28
chr10_73514684_73515259	0.17	C10orf54	chromosome 10 open reading frame 54	2416	0.29
chr17_20435355_20435506	0.17	AC015818.3		8370	0.16
chr5_141017161_141017642	0.17	RELL2	RELT-like 2	392	0.67
chr2_240170929_240171080	0.17	ENSG00000265215	.	56153	0.1
chr10_72647360_72647920	0.17	PCBD1	pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha	901	0.61
chr19_53971416_53971567	0.17	ZNF813	zinc finger protein 813	491	0.73
chr8_144479919_144480248	0.17	RP11-909N17.2		14836	0.09
chr20_3062971_3063207	0.17	AVP	arginine vasopressin	2281	0.19
chr1_955590_955924	0.17	AGRN	agrin	254	0.82
chr19_1408158_1408394	0.17	DAZAP1	DAZ associated protein 1	542	0.53
chr11_1593630_1593781	0.17	KRTAP5-AS1	KRTAP5-1/KRTAP5-2 antisense RNA 1	266	0.69
chr19_1757452_1757848	0.17	ONECUT3	one cut homeobox 3	5278	0.14
chr19_34286590_34286927	0.17	KCTD15	potassium channel tetramerization domain containing 15	80	0.98
chr15_101676818_101676969	0.17	RP11-505E24.2		50622	0.14
chr2_174127618_174127769	0.17	MLK7-AS1	MLK7 antisense RNA 1	8655	0.3
chr10_134441856_134442007	0.17	INPP5A	inositol polyphosphate-5-phosphatase, 40kDa	20501	0.24
chr7_156400190_156400570	0.17	ENSG00000182648	.	1922	0.35
chr5_72742553_72742920	0.17	FOXD1	forkhead box D1	1616	0.4
chr2_36583944_36584246	0.17	CRIM1	cysteine rich transmembrane BMP regulator 1 (chordin-like)	481	0.89
chr22_50616510_50616763	0.17	PANX2	pannexin 2	7476	0.09
chrX_153824799_153824991	0.17	CTAG1A	cancer/testis antigen 1A	11477	0.11
chr9_129232305_129232865	0.17	ENSG00000252985	.	43413	0.14
chr19_41329835_41330195	0.17	EGLN2	egl-9 family hypoxia-inducible factor 2	16867	0.11
chr17_58216738_58217239	0.17	CA4	carbonic anhydrase IV	10309	0.17
chr5_139026736_139026950	0.17	CXXC5	CXXC finger protein 5	41	0.98
chr16_88759405_88759694	0.17	RP5-1142A6.5		3360	0.09
chr8_126518150_126518406	0.17	ENSG00000266452	.	61471	0.13
chr9_130601372_130601801	0.16	ENSG00000222455	.	1915	0.15
chr11_3164459_3164610	0.16	OSBPL5	oxysterol binding protein-like 5	13975	0.15
chr22_42679390_42679541	0.16	TCF20	transcription factor 20 (AR1)	60157	0.11
chr11_64059326_64060001	0.16	KCNK4	potassium channel, subfamily K, member 4	181	0.83
chr21_15588417_15588693	0.16	RBM11	RNA binding motif protein 11	56	0.98
chr3_85009901_85010052	0.16	CADM2	cell adhesion molecule 2	1279	0.6
chr19_497502_497658	0.16	MADCAM1	mucosal vascular addressin cell adhesion molecule 1	1080	0.32
chrX_139846898_139847148	0.16	CDR1	cerebellar degeneration-related protein 1, 34kDa	19700	0.22
chr2_27303559_27303835	0.16	EMILIN1	elastin microfibril interfacer 1	2262	0.12
chr10_104436480_104437015	0.16	TRIM8	tripartite motif containing 8	32103	0.12
chr17_76408680_76409216	0.16	PGS1	phosphatidylglycerophosphate synthase 1	8903	0.14
chr19_1154320_1154471	0.16	SBNO2	strawberry notch homolog 2 (Drosophila)	740	0.54
chr19_3428790_3429002	0.16	C19orf77	chromosome 19 open reading frame 77	49590	0.08
chr16_23859758_23859996	0.16	PRKCB	protein kinase C, beta	11333	0.24
chr19_51842265_51842416	0.16	CTD-2616J11.16		1609	0.17
chr8_98656994_98657282	0.16	MTDH	metadherin	117	0.98
chr7_149156298_149156814	0.16	ZNF777	zinc finger protein 777	1658	0.41
chr3_128568896_128569192	0.16	RP11-723O4.2		15403	0.17
chr6_43739183_43739466	0.16	VEGFA	vascular endothelial growth factor A	340	0.78
chr1_205012234_205012598	0.16	CNTN2	contactin 2 (axonal)	91	0.97
chr2_10425893_10426393	0.16	ENSG00000264030	.	5386	0.18

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of SIN3A_CHD1

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View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.5	GO:0045163	clustering of voltage-gated potassium channels(GO:0045163)
0.1	0.6	GO:0032808	lacrimal gland development(GO:0032808)
0.1	0.5	GO:0060754	mast cell chemotaxis(GO:0002551) regulation of mast cell chemotaxis(GO:0060753) positive regulation of mast cell chemotaxis(GO:0060754) mast cell migration(GO:0097531)
0.1	0.3	GO:0032927	positive regulation of activin receptor signaling pathway(GO:0032927)
0.1	0.3	GO:0060242	contact inhibition(GO:0060242)
0.1	0.4	GO:0060028	convergent extension involved in axis elongation(GO:0060028)
0.1	0.2	GO:0033622	integrin activation(GO:0033622)
0.1	0.4	GO:0022011	myelination in peripheral nervous system(GO:0022011) peripheral nervous system axon ensheathment(GO:0032292)
0.1	0.2	GO:0030644	cellular chloride ion homeostasis(GO:0030644) chloride ion homeostasis(GO:0055064)
0.1	0.2	GO:0021780	spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) oligodendrocyte cell fate specification(GO:0021778) glial cell fate specification(GO:0021780)
0.1	0.1	GO:0035405	histone-threonine phosphorylation(GO:0035405)
0.1	0.2	GO:0060235	lens induction in camera-type eye(GO:0060235)
0.0	0.2	GO:0048935	peripheral nervous system neuron development(GO:0048935)
0.0	0.1	GO:0002025	vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure(GO:0002025)
0.0	0.1	GO:0044321	cellular response to leptin stimulus(GO:0044320) response to leptin(GO:0044321)
0.0	0.1	GO:0015825	L-serine transport(GO:0015825)
0.0	0.1	GO:0010842	retina layer formation(GO:0010842)
0.0	0.1	GO:0018125	peptidyl-cysteine methylation(GO:0018125)
0.0	0.1	GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.0	0.0	GO:2000300	regulation of synaptic vesicle transport(GO:1902803) regulation of synaptic vesicle exocytosis(GO:2000300)
0.0	0.1	GO:0032730	regulation of interleukin-1 alpha production(GO:0032650) positive regulation of interleukin-1 alpha production(GO:0032730)
0.0	0.1	GO:0045110	intermediate filament bundle assembly(GO:0045110)
0.0	0.0	GO:0002032	desensitization of G-protein coupled receptor protein signaling pathway by arrestin(GO:0002032)
0.0	0.2	GO:0016102	retinoic acid biosynthetic process(GO:0002138) diterpenoid biosynthetic process(GO:0016102)
0.0	0.1	GO:0061072	iris morphogenesis(GO:0061072)
0.0	0.3	GO:0010560	positive regulation of glycoprotein biosynthetic process(GO:0010560) positive regulation of glycoprotein metabolic process(GO:1903020)
0.0	0.2	GO:0055026	negative regulation of cardiac muscle tissue growth(GO:0055022) negative regulation of cardiac muscle tissue development(GO:0055026) negative regulation of cardiac muscle cell proliferation(GO:0060044) negative regulation of heart growth(GO:0061117)
0.0	0.2	GO:0090049	regulation of cell migration involved in sprouting angiogenesis(GO:0090049) regulation of sprouting angiogenesis(GO:1903670)
0.0	0.2	GO:0010508	positive regulation of autophagy(GO:0010508)
0.0	0.2	GO:0045662	negative regulation of myoblast differentiation(GO:0045662)
0.0	0.2	GO:0019987	obsolete negative regulation of anti-apoptosis(GO:0019987)
0.0	0.1	GO:0072217	negative regulation of metanephros development(GO:0072217)
0.0	0.1	GO:0001574	ganglioside biosynthetic process(GO:0001574)
0.0	0.1	GO:0032926	negative regulation of activin receptor signaling pathway(GO:0032926)
0.0	0.2	GO:0031061	negative regulation of histone methylation(GO:0031061)
0.0	0.1	GO:0006435	threonyl-tRNA aminoacylation(GO:0006435)
0.0	0.1	GO:0001711	endodermal cell fate commitment(GO:0001711) endodermal cell fate specification(GO:0001714) endodermal cell differentiation(GO:0035987) regulation of endodermal cell fate specification(GO:0042663) regulation of endodermal cell differentiation(GO:1903224)
0.0	0.4	GO:0031581	hemidesmosome assembly(GO:0031581)
0.0	0.3	GO:0033144	negative regulation of intracellular steroid hormone receptor signaling pathway(GO:0033144)
0.0	0.1	GO:0051124	synaptic growth at neuromuscular junction(GO:0051124)
0.0	0.1	GO:0019276	UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.0	0.1	GO:0016241	regulation of macroautophagy(GO:0016241) negative regulation of macroautophagy(GO:0016242)
0.0	0.2	GO:0002313	mature B cell differentiation involved in immune response(GO:0002313)
0.0	0.1	GO:0006556	S-adenosylmethionine biosynthetic process(GO:0006556)
0.0	0.1	GO:0070932	histone H3 deacetylation(GO:0070932) histone H4 deacetylation(GO:0070933)
0.0	0.2	GO:0032717	negative regulation of interleukin-8 production(GO:0032717)
0.0	0.2	GO:0050930	induction of positive chemotaxis(GO:0050930)
0.0	0.1	GO:0034723	DNA replication-dependent nucleosome organization(GO:0034723)
0.0	0.1	GO:0033152	immunoglobulin V(D)J recombination(GO:0033152)
0.0	0.1	GO:0060023	soft palate development(GO:0060023)
0.0	0.1	GO:0071731	response to nitric oxide(GO:0071731)
0.0	0.1	GO:0021913	regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913)
0.0	0.2	GO:0048895	sensory system development(GO:0048880) lateral line nerve development(GO:0048892) lateral line nerve glial cell differentiation(GO:0048895) lateral line system development(GO:0048925) lateral line nerve glial cell development(GO:0048937) iridophore differentiation(GO:0050935)
0.0	0.2	GO:0030853	negative regulation of granulocyte differentiation(GO:0030853)
0.0	0.1	GO:0051001	negative regulation of nitric-oxide synthase activity(GO:0051001)
0.0	0.1	GO:0032227	negative regulation of synaptic transmission, dopaminergic(GO:0032227)
0.0	0.1	GO:2000095	regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000095)
0.0	0.1	GO:0010614	negative regulation of cardiac muscle hypertrophy(GO:0010614)
0.0	0.0	GO:0043380	T-helper cell lineage commitment(GO:0002295) CD4-positive, alpha-beta T cell lineage commitment(GO:0043373) memory T cell differentiation(GO:0043379) regulation of memory T cell differentiation(GO:0043380) positive regulation of memory T cell differentiation(GO:0043382) T-helper 17 type immune response(GO:0072538) T-helper 17 cell differentiation(GO:0072539) T-helper 17 cell lineage commitment(GO:0072540) regulation of T-helper 17 type immune response(GO:2000316) positive regulation of T-helper 17 type immune response(GO:2000318) regulation of T-helper 17 cell differentiation(GO:2000319) positive regulation of T-helper 17 cell differentiation(GO:2000321) regulation of T-helper 17 cell lineage commitment(GO:2000328) positive regulation of T-helper 17 cell lineage commitment(GO:2000330)
0.0	0.1	GO:0031558	obsolete induction of apoptosis in response to chemical stimulus(GO:0031558)
0.0	0.1	GO:0003056	regulation of vascular smooth muscle contraction(GO:0003056)
0.0	0.1	GO:0035054	embryonic heart tube anterior/posterior pattern specification(GO:0035054)
0.0	0.1	GO:0003077	obsolete negative regulation of diuresis(GO:0003077)
0.0	0.2	GO:0007172	signal complex assembly(GO:0007172)
0.0	0.1	GO:0008615	pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 metabolic process(GO:0042816) vitamin B6 biosynthetic process(GO:0042819)
0.0	0.0	GO:0070141	response to UV-A(GO:0070141)
0.0	0.0	GO:0002328	pro-B cell differentiation(GO:0002328)
0.0	0.2	GO:0070265	necrotic cell death(GO:0070265)
0.0	0.0	GO:0060648	mammary gland bud morphogenesis(GO:0060648)
0.0	0.1	GO:0000089	mitotic metaphase(GO:0000089)
0.0	0.1	GO:0010592	positive regulation of lamellipodium assembly(GO:0010592) positive regulation of lamellipodium organization(GO:1902745)
0.0	0.1	GO:0045924	regulation of female receptivity(GO:0045924) female mating behavior(GO:0060180)
0.0	0.1	GO:0016188	synaptic vesicle maturation(GO:0016188)
0.0	0.4	GO:0032012	regulation of ARF protein signal transduction(GO:0032012)
0.0	0.0	GO:0022009	establishment of endothelial blood-brain barrier(GO:0014045) central nervous system vasculogenesis(GO:0022009)
0.0	0.1	GO:0090136	epithelial cell-cell adhesion(GO:0090136)
0.0	0.1	GO:0045343	MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343)
0.0	0.1	GO:0046827	positive regulation of protein export from nucleus(GO:0046827)
0.0	0.0	GO:0048934	peripheral nervous system neuron differentiation(GO:0048934)
0.0	0.1	GO:0040015	negative regulation of multicellular organism growth(GO:0040015)
0.0	0.1	GO:0055098	response to low-density lipoprotein particle(GO:0055098)
0.0	0.1	GO:0007000	nucleolus organization(GO:0007000)
0.0	0.2	GO:0000085	mitotic G2 phase(GO:0000085) G2 phase(GO:0051319)
0.0	0.0	GO:0051154	negative regulation of striated muscle cell differentiation(GO:0051154)
0.0	0.1	GO:0048702	embryonic neurocranium morphogenesis(GO:0048702)
0.0	0.0	GO:0030538	embryonic genitalia morphogenesis(GO:0030538)
0.0	0.1	GO:0009804	phenylpropanoid metabolic process(GO:0009698) coumarin metabolic process(GO:0009804)
0.0	0.1	GO:0016322	neuron remodeling(GO:0016322)
0.0	0.3	GO:0034199	activation of protein kinase A activity(GO:0034199)
0.0	0.1	GO:0051873	disruption by host of symbiont cells(GO:0051852) killing by host of symbiont cells(GO:0051873)
0.0	0.1	GO:0033197	response to vitamin E(GO:0033197)
0.0	0.1	GO:0032898	neurotrophin production(GO:0032898)
0.0	0.1	GO:0006729	tetrahydrobiopterin biosynthetic process(GO:0006729)
0.0	0.1	GO:0045767	obsolete regulation of anti-apoptosis(GO:0045767)
0.0	0.2	GO:0032733	positive regulation of interleukin-10 production(GO:0032733)
0.0	0.1	GO:0002282	microglial cell activation involved in immune response(GO:0002282)
0.0	0.0	GO:0003402	planar cell polarity pathway involved in axis elongation(GO:0003402)
0.0	0.0	GO:0007500	mesodermal cell fate determination(GO:0007500)
0.0	0.1	GO:0017000	antibiotic metabolic process(GO:0016999) antibiotic biosynthetic process(GO:0017000)
0.0	0.1	GO:0010447	response to acidic pH(GO:0010447)
0.0	0.1	GO:0046655	folic acid metabolic process(GO:0046655)
0.0	0.1	GO:0010586	miRNA metabolic process(GO:0010586) miRNA catabolic process(GO:0010587)
0.0	0.0	GO:0051971	positive regulation of transmission of nerve impulse(GO:0051971)
0.0	0.1	GO:0045071	negative regulation of viral genome replication(GO:0045071)
0.0	0.2	GO:0007076	mitotic chromosome condensation(GO:0007076)
0.0	0.2	GO:0032332	positive regulation of chondrocyte differentiation(GO:0032332)
0.0	0.0	GO:0001921	positive regulation of receptor recycling(GO:0001921)
0.0	0.1	GO:0030033	microvillus assembly(GO:0030033) microvillus organization(GO:0032528)
0.0	0.4	GO:0006904	vesicle docking involved in exocytosis(GO:0006904)
0.0	0.0	GO:0034983	peptidyl-lysine deacetylation(GO:0034983)
0.0	0.1	GO:0006020	inositol metabolic process(GO:0006020)
0.0	0.1	GO:0040019	positive regulation of embryonic development(GO:0040019)
0.0	0.1	GO:0032968	positive regulation of transcription elongation from RNA polymerase II promoter(GO:0032968)
0.0	0.1	GO:0016093	polyprenol metabolic process(GO:0016093) dolichol metabolic process(GO:0019348)
0.0	0.1	GO:0060836	lymphatic endothelial cell differentiation(GO:0060836)
0.0	0.1	GO:0045085	negative regulation of interleukin-2 biosynthetic process(GO:0045085)
0.0	0.0	GO:0006295	nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295)
0.0	0.1	GO:0006538	glutamate catabolic process(GO:0006538)
0.0	0.1	GO:0006685	sphingomyelin catabolic process(GO:0006685)
0.0	0.1	GO:0051973	positive regulation of telomerase activity(GO:0051973)
0.0	0.0	GO:2000757	negative regulation of histone acetylation(GO:0035067) negative regulation of protein acetylation(GO:1901984) negative regulation of peptidyl-lysine acetylation(GO:2000757)
0.0	0.0	GO:0031659	regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle(GO:0031657) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle(GO:0031659)
0.0	0.1	GO:0042117	monocyte activation(GO:0042117)
0.0	0.0	GO:0030091	protein repair(GO:0030091)
0.0	0.1	GO:0090231	regulation of spindle checkpoint(GO:0090231)
0.0	0.1	GO:0050435	beta-amyloid metabolic process(GO:0050435)
0.0	0.1	GO:0045625	regulation of T-helper 1 cell differentiation(GO:0045625)
0.0	0.0	GO:0018076	N-terminal peptidyl-lysine acetylation(GO:0018076)
0.0	0.0	GO:0051709	regulation of killing of cells of other organism(GO:0051709) positive regulation of killing of cells of other organism(GO:0051712)
0.0	0.0	GO:0045079	negative regulation of chemokine production(GO:0032682) negative regulation of chemokine biosynthetic process(GO:0045079)
0.0	0.1	GO:0015919	peroxisomal membrane transport(GO:0015919)
0.0	0.1	GO:0055015	ventricular cardiac muscle cell development(GO:0055015)
0.0	0.0	GO:0034135	regulation of toll-like receptor 2 signaling pathway(GO:0034135)
0.0	0.2	GO:0007342	fusion of sperm to egg plasma membrane(GO:0007342)
0.0	0.0	GO:0042219	cellular modified amino acid catabolic process(GO:0042219)
0.0	0.1	GO:0003310	pancreatic A cell differentiation(GO:0003310)
0.0	0.0	GO:0002281	macrophage activation involved in immune response(GO:0002281)
0.0	0.1	GO:0090023	positive regulation of neutrophil chemotaxis(GO:0090023) positive regulation of neutrophil migration(GO:1902624)
0.0	0.0	GO:0010882	regulation of cardiac muscle contraction by calcium ion signaling(GO:0010882)
0.0	0.1	GO:0050957	equilibrioception(GO:0050957)
0.0	0.0	GO:0014051	gamma-aminobutyric acid secretion(GO:0014051) regulation of gamma-aminobutyric acid secretion(GO:0014052)
0.0	0.1	GO:0009109	coenzyme catabolic process(GO:0009109)
0.0	0.0	GO:0010457	centriole-centriole cohesion(GO:0010457)
0.0	0.0	GO:0009180	ADP biosynthetic process(GO:0006172) purine nucleoside diphosphate biosynthetic process(GO:0009136) purine ribonucleoside diphosphate biosynthetic process(GO:0009180) ribonucleoside diphosphate biosynthetic process(GO:0009188)
0.0	0.1	GO:0051972	regulation of telomerase activity(GO:0051972)
0.0	0.0	GO:0030187	melatonin metabolic process(GO:0030186) melatonin biosynthetic process(GO:0030187)
0.0	0.1	GO:0002089	lens morphogenesis in camera-type eye(GO:0002089)
0.0	0.0	GO:0006384	transcription initiation from RNA polymerase III promoter(GO:0006384)
0.0	0.1	GO:0042119	neutrophil activation(GO:0042119)
0.0	0.1	GO:0060527	prostate glandular acinus morphogenesis(GO:0060526) prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis(GO:0060527)
0.0	0.0	GO:0043276	anoikis(GO:0043276)
0.0	0.0	GO:0000733	DNA strand renaturation(GO:0000733)
0.0	0.0	GO:0010459	negative regulation of heart rate(GO:0010459)
0.0	0.0	GO:0048478	replication fork protection(GO:0048478)
0.0	0.1	GO:0002478	antigen processing and presentation of exogenous peptide antigen(GO:0002478)
0.0	0.1	GO:0060456	positive regulation of digestive system process(GO:0060456)
0.0	0.1	GO:0060391	positive regulation of SMAD protein import into nucleus(GO:0060391)
0.0	0.1	GO:0015871	choline transport(GO:0015871)
0.0	0.0	GO:0071436	sodium ion export(GO:0071436)
0.0	0.1	GO:0007549	dosage compensation(GO:0007549)
0.0	0.0	GO:0009189	deoxyribonucleoside diphosphate biosynthetic process(GO:0009189)
0.0	0.0	GO:0043983	histone H4-K12 acetylation(GO:0043983)
0.0	0.0	GO:0046931	pore complex assembly(GO:0046931)
0.0	0.1	GO:0016558	protein import into peroxisome matrix(GO:0016558)
0.0	0.0	GO:0010815	bradykinin catabolic process(GO:0010815)
0.0	0.0	GO:0032237	activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0	0.1	GO:0040023	establishment of nucleus localization(GO:0040023)
0.0	0.1	GO:0006689	ganglioside catabolic process(GO:0006689)
0.0	0.1	GO:0007185	transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0	0.0	GO:0045603	positive regulation of endothelial cell differentiation(GO:0045603)
0.0	0.0	GO:0002513	tolerance induction to self antigen(GO:0002513)
0.0	0.0	GO:0002361	CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0002361)
0.0	0.1	GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:0006978)
0.0	0.0	GO:0032011	ARF protein signal transduction(GO:0032011)
0.0	0.0	GO:0051386	regulation of neurotrophin TRK receptor signaling pathway(GO:0051386)
0.0	0.0	GO:0006208	pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) thymine metabolic process(GO:0019859)
0.0	0.0	GO:0009756	carbohydrate mediated signaling(GO:0009756)
0.0	0.0	GO:0006772	thiamine metabolic process(GO:0006772)
0.0	0.1	GO:0048630	skeletal muscle tissue growth(GO:0048630)
0.0	0.1	GO:0015671	oxygen transport(GO:0015671)
0.0	0.0	GO:0006498	N-terminal protein lipidation(GO:0006498)
0.0	0.0	GO:0001911	negative regulation of leukocyte mediated cytotoxicity(GO:0001911)
0.0	0.1	GO:0015911	plasma membrane long-chain fatty acid transport(GO:0015911)
0.0	0.0	GO:0046968	peptide antigen transport(GO:0046968)
0.0	0.3	GO:0003333	amino acid transmembrane transport(GO:0003333)
0.0	0.1	GO:0043954	cell junction maintenance(GO:0034331) cellular component maintenance(GO:0043954) cell-cell junction maintenance(GO:0045217)
0.0	0.1	GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway(GO:0030511) positive regulation of cellular response to transforming growth factor beta stimulus(GO:1903846)
0.0	0.1	GO:0070570	regulation of axon regeneration(GO:0048679) regulation of neuron projection regeneration(GO:0070570)
0.0	0.1	GO:0055078	sodium ion homeostasis(GO:0055078)
0.0	0.0	GO:0070172	positive regulation of tooth mineralization(GO:0070172)
0.0	0.0	GO:0001845	phagolysosome assembly(GO:0001845) phagosome maturation(GO:0090382)
0.0	0.0	GO:0009301	snRNA transcription(GO:0009301)
0.0	0.0	GO:0032613	interleukin-10 production(GO:0032613)
0.0	0.0	GO:0045006	DNA deamination(GO:0045006)
0.0	0.1	GO:0050832	defense response to fungus(GO:0050832)
0.0	0.0	GO:0050689	negative regulation of defense response to virus by host(GO:0050689)
0.0	0.0	GO:0032971	regulation of muscle filament sliding(GO:0032971) regulation of actin filament-based movement(GO:1903115)
0.0	0.0	GO:0061318	renal filtration cell differentiation(GO:0061318) glomerular epithelium development(GO:0072010) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.0	0.0	GO:0060008	Sertoli cell differentiation(GO:0060008) Sertoli cell development(GO:0060009)
0.0	0.0	GO:0006591	ornithine metabolic process(GO:0006591)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0031235	intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.1	0.2	GO:0070852	cell body fiber(GO:0070852)
0.1	0.2	GO:0034673	inhibin-betaglycan-ActRII complex(GO:0034673)
0.1	0.3	GO:0033268	node of Ranvier(GO:0033268)
0.0	0.2	GO:0005638	lamin filament(GO:0005638)
0.0	0.3	GO:0016461	unconventional myosin complex(GO:0016461)
0.0	0.2	GO:0001939	female pronucleus(GO:0001939)
0.0	0.3	GO:0032839	dendrite cytoplasm(GO:0032839)
0.0	0.6	GO:0005720	nuclear heterochromatin(GO:0005720)
0.0	0.1	GO:0071986	Ragulator complex(GO:0071986)
0.0	0.1	GO:0000800	lateral element(GO:0000800)
0.0	0.1	GO:0005594	collagen type IX trimer(GO:0005594)
0.0	0.1	GO:0000137	Golgi cis cisterna(GO:0000137)
0.0	0.1	GO:0070776	H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0	0.1	GO:0048179	activin receptor complex(GO:0048179)
0.0	0.3	GO:0001772	immunological synapse(GO:0001772)
0.0	0.1	GO:0032009	early phagosome(GO:0032009)
0.0	0.1	GO:0071664	catenin-TCF7L2 complex(GO:0071664)
0.0	0.1	GO:0016533	cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.0	0.1	GO:0046581	intercellular canaliculus(GO:0046581)
0.0	0.1	GO:0000300	obsolete peripheral to membrane of membrane fraction(GO:0000300)
0.0	0.1	GO:0031254	uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0	0.1	GO:0014731	spectrin-associated cytoskeleton(GO:0014731)
0.0	0.1	GO:0070022	transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0	0.1	GO:0042824	MHC class I peptide loading complex(GO:0042824)
0.0	0.1	GO:0030056	hemidesmosome(GO:0030056)
0.0	0.3	GO:0030867	rough endoplasmic reticulum membrane(GO:0030867)
0.0	0.1	GO:0005678	obsolete chromatin assembly complex(GO:0005678)
0.0	0.1	GO:0030893	meiotic cohesin complex(GO:0030893)
0.0	0.2	GO:0005952	cAMP-dependent protein kinase complex(GO:0005952)
0.0	0.1	GO:0005845	mRNA cap binding complex(GO:0005845) RNA cap binding complex(GO:0034518)
0.0	0.0	GO:0044462	external encapsulating structure part(GO:0044462)
0.0	0.2	GO:0031258	lamellipodium membrane(GO:0031258)
0.0	0.2	GO:0031519	PcG protein complex(GO:0031519)
0.0	0.1	GO:0016589	NURF complex(GO:0016589)
0.0	0.2	GO:0031105	septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.0	0.1	GO:0030673	axolemma(GO:0030673)
0.0	0.0	GO:0030895	apolipoprotein B mRNA editing enzyme complex(GO:0030895)
0.0	0.0	GO:0000124	SAGA complex(GO:0000124)
0.0	0.1	GO:0001740	Barr body(GO:0001740)
0.0	0.0	GO:1990316	ATG1/ULK1 kinase complex(GO:1990316)
0.0	0.1	GO:0008278	cohesin complex(GO:0008278)
0.0	0.4	GO:0005884	actin filament(GO:0005884)
0.0	0.1	GO:0033179	proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.0	0.1	GO:0035189	Rb-E2F complex(GO:0035189)
0.0	0.0	GO:0070820	tertiary granule(GO:0070820)
0.0	0.1	GO:0001527	microfibril(GO:0001527)
0.0	0.0	GO:0045323	interleukin-1 receptor complex(GO:0045323)
0.0	0.1	GO:0042382	paraspeckles(GO:0042382)
0.0	0.0	GO:0031527	filopodium membrane(GO:0031527)
0.0	0.2	GO:0043198	dendritic shaft(GO:0043198)
0.0	0.0	GO:0042105	alpha-beta T cell receptor complex(GO:0042105)
0.0	0.1	GO:0031264	death-inducing signaling complex(GO:0031264)
0.0	0.1	GO:0005665	DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0	0.0	GO:0031045	dense core granule(GO:0031045)
0.0	0.1	GO:0005833	hemoglobin complex(GO:0005833)
0.0	0.0	GO:0071437	invadopodium(GO:0071437)
0.0	0.0	GO:0032449	CBM complex(GO:0032449)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.5	GO:0005078	MAP-kinase scaffold activity(GO:0005078)
0.1	0.3	GO:0043184	vascular endothelial growth factor receptor 2 binding(GO:0043184)
0.1	0.3	GO:0016362	activin receptor activity, type II(GO:0016362)
0.1	0.2	GO:0003680	AT DNA binding(GO:0003680)
0.1	0.2	GO:0070324	thyroid hormone binding(GO:0070324)
0.1	0.4	GO:0043522	leucine zipper domain binding(GO:0043522)
0.1	0.3	GO:0004111	creatine kinase activity(GO:0004111)
0.1	0.2	GO:0005172	vascular endothelial growth factor receptor binding(GO:0005172)
0.1	0.3	GO:0034237	protein kinase A regulatory subunit binding(GO:0034237)
0.1	0.2	GO:0070097	delta-catenin binding(GO:0070097)
0.1	0.8	GO:0031490	chromatin DNA binding(GO:0031490)
0.0	0.1	GO:0004939	beta-adrenergic receptor activity(GO:0004939)
0.0	0.1	GO:0015194	L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.0	0.1	GO:0008332	low voltage-gated calcium channel activity(GO:0008332)
0.0	0.2	GO:0005010	insulin-like growth factor-activated receptor activity(GO:0005010)
0.0	0.2	GO:0008504	monoamine transmembrane transporter activity(GO:0008504)
0.0	0.1	GO:0000268	peroxisome targeting sequence binding(GO:0000268)
0.0	0.1	GO:0004829	threonine-tRNA ligase activity(GO:0004829)
0.0	0.3	GO:0017075	syntaxin-1 binding(GO:0017075)
0.0	0.1	GO:0001849	complement component C1q binding(GO:0001849)
0.0	0.1	GO:0048027	mRNA 5'-UTR binding(GO:0048027)
0.0	0.1	GO:0070644	vitamin D response element binding(GO:0070644)
0.0	0.1	GO:0004768	stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215)
0.0	0.1	GO:0004427	inorganic diphosphatase activity(GO:0004427)
0.0	0.1	GO:0005173	stem cell factor receptor binding(GO:0005173)
0.0	0.3	GO:0031078	histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) histone deacetylase activity (H4-K16 specific)(GO:0034739) NAD-dependent histone deacetylase activity (H4-K16 specific)(GO:0046970)
0.0	0.1	GO:0035184	histone threonine kinase activity(GO:0035184)
0.0	0.1	GO:0047631	ADP-ribose diphosphatase activity(GO:0047631)
0.0	0.1	GO:0035197	siRNA binding(GO:0035197)
0.0	0.2	GO:0030676	Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0	0.2	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0	0.2	GO:0001085	RNA polymerase II transcription factor binding(GO:0001085)
0.0	0.1	GO:0043539	protein serine/threonine kinase activator activity(GO:0043539)
0.0	0.1	GO:0042289	MHC class II protein binding(GO:0042289)
0.0	0.1	GO:0000982	transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0000982) transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0	0.1	GO:0004911	interleukin-2 receptor activity(GO:0004911)
0.0	0.1	GO:0004792	thiosulfate sulfurtransferase activity(GO:0004792)
0.0	0.1	GO:0035014	phosphatidylinositol 3-kinase regulator activity(GO:0035014)
0.0	0.1	GO:0052659	inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658) inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity(GO:0052659)
0.0	0.1	GO:0016509	long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0016509)
0.0	0.1	GO:0005148	prolactin receptor binding(GO:0005148)
0.0	0.1	GO:0004090	carbonyl reductase (NADPH) activity(GO:0004090)
0.0	0.4	GO:0005086	ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0	0.0	GO:0008179	adenylate cyclase binding(GO:0008179)
0.0	0.1	GO:0070696	transmembrane receptor protein serine/threonine kinase binding(GO:0070696)
0.0	0.1	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977) RNA polymerase II regulatory region DNA binding(GO:0001012)
0.0	0.1	GO:0005250	A-type (transient outward) potassium channel activity(GO:0005250)
0.0	0.1	GO:0008294	calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.0	0.1	GO:0004563	beta-N-acetylhexosaminidase activity(GO:0004563)
0.0	0.1	GO:0033743	peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.0	0.1	GO:0031177	phosphopantetheine binding(GO:0031177)
0.0	0.1	GO:0010521	telomerase inhibitor activity(GO:0010521)
0.0	0.2	GO:0033613	activating transcription factor binding(GO:0033613)
0.0	0.1	GO:0016941	natriuretic peptide receptor activity(GO:0016941)
0.0	0.0	GO:0005025	transforming growth factor beta receptor activity, type I(GO:0005025)
0.0	0.1	GO:0047184	1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184)
0.0	0.1	GO:0004596	peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0	0.1	GO:0005346	purine ribonucleotide transmembrane transporter activity(GO:0005346)
0.0	0.1	GO:0004703	G-protein coupled receptor kinase activity(GO:0004703)
0.0	0.1	GO:0010485	H4 histone acetyltransferase activity(GO:0010485)
0.0	0.1	GO:0030306	ADP-ribosylation factor binding(GO:0030306)
0.0	0.1	GO:0032450	maltose alpha-glucosidase activity(GO:0032450)
0.0	0.1	GO:0004791	thioredoxin-disulfide reductase activity(GO:0004791)
0.0	0.0	GO:0004999	vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.0	0.1	GO:0016812	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812)
0.0	0.2	GO:0048185	activin binding(GO:0048185)
0.0	0.1	GO:0032794	GTPase activating protein binding(GO:0032794)
0.0	0.1	GO:0004505	phenylalanine 4-monooxygenase activity(GO:0004505)
0.0	0.1	GO:0004767	sphingomyelin phosphodiesterase activity(GO:0004767)
0.0	0.1	GO:0031491	nucleosome binding(GO:0031491)
0.0	0.1	GO:0008273	calcium, potassium:sodium antiporter activity(GO:0008273)
0.0	0.0	GO:0008321	Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0	0.1	GO:0004035	alkaline phosphatase activity(GO:0004035)
0.0	0.2	GO:0005527	macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0	0.1	GO:0015385	sodium:proton antiporter activity(GO:0015385)
0.0	0.0	GO:0019863	IgE binding(GO:0019863)
0.0	0.2	GO:0019841	retinol binding(GO:0019841)
0.0	0.1	GO:0061133	endopeptidase activator activity(GO:0061133)
0.0	0.1	GO:0016416	carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.0	0.0	GO:0004351	glutamate decarboxylase activity(GO:0004351)
0.0	0.0	GO:0047623	AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0	0.1	GO:0051864	histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0	0.2	GO:0042605	peptide antigen binding(GO:0042605)
0.0	0.1	GO:0004994	somatostatin receptor activity(GO:0004994)
0.0	0.0	GO:0005152	interleukin-1 receptor antagonist activity(GO:0005152)
0.0	0.1	GO:0019911	structural constituent of myelin sheath(GO:0019911)
0.0	0.0	GO:0070548	L-glutamine aminotransferase activity(GO:0070548)
0.0	0.1	GO:0004704	NF-kappaB-inducing kinase activity(GO:0004704)
0.0	0.1	GO:0008508	bile acid:sodium symporter activity(GO:0008508)
0.0	0.1	GO:0005315	inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0	0.0	GO:0016748	succinyltransferase activity(GO:0016748)
0.0	0.0	GO:0047894	flavonol 3-sulfotransferase activity(GO:0047894)
0.0	0.0	GO:0004873	asialoglycoprotein receptor activity(GO:0004873)
0.0	0.0	GO:0070576	vitamin D 24-hydroxylase activity(GO:0070576)
0.0	0.0	GO:0046923	ER retention sequence binding(GO:0046923)
0.0	0.1	GO:0045499	chemorepellent activity(GO:0045499)
0.0	0.1	GO:0004016	adenylate cyclase activity(GO:0004016)
0.0	0.0	GO:0002162	dystroglycan binding(GO:0002162)
0.0	0.1	GO:0015220	choline transmembrane transporter activity(GO:0015220)
0.0	0.0	GO:0003910	DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.0	0.1	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.0	0.0	GO:0017162	aryl hydrocarbon receptor binding(GO:0017162)
0.0	0.1	GO:0001609	G-protein coupled adenosine receptor activity(GO:0001609)
0.0	0.1	GO:0043140	ATP-dependent 3'-5' DNA helicase activity(GO:0043140)
0.0	0.0	GO:0019797	procollagen-proline 3-dioxygenase activity(GO:0019797) peptidyl-proline 3-dioxygenase activity(GO:0031544)
0.0	0.0	GO:0004311	farnesyltranstransferase activity(GO:0004311)
0.0	0.2	GO:0004089	carbonate dehydratase activity(GO:0004089)
0.0	0.1	GO:0016175	superoxide-generating NADPH oxidase activity(GO:0016175)
0.0	0.0	GO:0031014	troponin T binding(GO:0031014)
0.0	0.0	GO:0031821	G-protein coupled serotonin receptor binding(GO:0031821)
0.0	0.7	GO:0005089	Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0	0.1	GO:0004652	polynucleotide adenylyltransferase activity(GO:0004652)
0.0	0.0	GO:0050265	RNA uridylyltransferase activity(GO:0050265)
0.0	0.0	GO:0016909	JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0	0.1	GO:0070290	N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0	0.1	GO:0042043	neurexin family protein binding(GO:0042043)
0.0	0.1	GO:0043395	heparan sulfate proteoglycan binding(GO:0043395)
0.0	0.1	GO:0051636	obsolete Gram-negative bacterial cell surface binding(GO:0051636)
0.0	0.0	GO:0043024	ribosomal small subunit binding(GO:0043024)
0.0	0.1	GO:0019864	IgG binding(GO:0019864)
0.0	0.0	GO:0044020	histone methyltransferase activity (H4-R3 specific)(GO:0044020)
0.0	0.1	GO:0005110	frizzled-2 binding(GO:0005110)
0.0	0.0	GO:0008061	chitin binding(GO:0008061)
0.0	0.0	GO:0005113	patched binding(GO:0005113)
0.0	0.0	GO:0042156	obsolete zinc-mediated transcriptional activator activity(GO:0042156)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.4	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
1.0	PID RAC1 REG PATHWAY	Regulation of RAC1 activity
0.2	ST PAC1 RECEPTOR PATHWAY	PAC1 Receptor Pathway
0.0	PID ERBB4 PATHWAY	ErbB4 signaling events
0.2	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.3	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.1	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.3	ST GA12 PATHWAY	G alpha 12 Pathway
0.1	PID SYNDECAN 2 PATHWAY	Syndecan-2-mediated signaling events
0.4	PID ALK1 PATHWAY	ALK1 signaling events
0.1	PID EPO PATHWAY	EPO signaling pathway
0.6	PID CERAMIDE PATHWAY	Ceramide signaling pathway
0.1	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
0.2	PID LPA4 PATHWAY	LPA4-mediated signaling events
0.0	PID S1P S1P2 PATHWAY	S1P2 pathway
0.0	PID MET PATHWAY	Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.1	PID PDGFRA PATHWAY	PDGFR-alpha signaling pathway
0.1	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.4	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.4	REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS	Genes involved in Tandem pore domain potassium channels
0.4	REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.3	REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	Genes involved in DCC mediated attractive signaling
0.3	REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY	Genes involved in Adenylate cyclase inhibitory pathway
0.2	REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB	Genes involved in PKA-mediated phosphorylation of CREB
0.0	REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN	Genes involved in Platelet Adhesion to exposed collagen
0.1	REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS	Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.1	REACTOME G PROTEIN BETA GAMMA SIGNALLING	Genes involved in G-protein beta:gamma signalling
0.2	REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX	Genes involved in Association of licensing factors with the pre-replicative complex
0.2	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING	Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.2	REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10	Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
0.2	REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE	Genes involved in Reversible Hydration of Carbon Dioxide
0.3	REACTOME CYTOSOLIC TRNA AMINOACYLATION	Genes involved in Cytosolic tRNA aminoacylation
0.2	REACTOME SIGNALING BY NODAL	Genes involved in Signaling by NODAL
0.1	REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION	Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.1	REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS	Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.4	REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	Genes involved in Amino acid transport across the plasma membrane
0.4	REACTOME RNA POL III TRANSCRIPTION	Genes involved in RNA Polymerase III Transcription
0.1	REACTOME FORMATION OF TRANSCRIPTION COUPLED NER TC NER REPAIR COMPLEX	Genes involved in Formation of transcription-coupled NER (TC-NER) repair complex
0.0	REACTOME SPRY REGULATION OF FGF SIGNALING	Genes involved in Spry regulation of FGF signaling
0.1	REACTOME VIRAL MESSENGER RNA SYNTHESIS	Genes involved in Viral Messenger RNA Synthesis
0.0	REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY	Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.2	REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP	Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.2	REACTOME SIGNALING BY HIPPO	Genes involved in Signaling by Hippo
0.3	REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX	Genes involved in Degradation of the extracellular matrix
0.1	REACTOME REGULATION OF KIT SIGNALING	Genes involved in Regulation of KIT signaling
0.2	REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.0	REACTOME G PROTEIN ACTIVATION	Genes involved in G-protein activation
0.1	REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS	Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.2	REACTOME GLUTATHIONE CONJUGATION	Genes involved in Glutathione conjugation
0.2	REACTOME REGULATION OF SIGNALING BY CBL	Genes involved in Regulation of signaling by CBL