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ENCODE: H3K4me1 ChIP-Seq of primary human cells
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Results for SIX4

Z-value: 1.03

Motif logo

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Transcription factors associated with SIX4

Gene Symbol Gene ID Gene Info
SIX4
ENSG00000100625.8 SIX homeobox 4

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr14_61187940_61188091SIX428370.2855390.655.9e-02Click!
chr14_61187585_61187736SIX431920.2698410.462.1e-01Click!
chr14_61190897_61191234SIX410.980903-0.462.1e-01Click!
chr14_61190696_61190847SIX4810.975517-0.373.2e-01Click!
chr14_61191436_61191587SIX44450.8453850.373.3e-01Click!

Activity of the SIX4 motif across conditions

Conditions sorted by the z-value of the SIX4 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr16_640639_641593 1.19 RAB40C
 RAB40C, member RAS oncogene family
 784
 0.37
chr10_182306_183031 0.58 ZMYND11
 zinc finger, MYND-type containing 11
 1219
 0.53
chr3_132255311_132255511 0.45 ACKR4
 atypical chemokine receptor 4
 60670
 0.13
chr12_68142396_68142547 0.37 RP11-335O4.3
77772
 0.11
chr13_113366659_113366810 0.35 ENSG00000264726
 .
 5494
 0.21
chr21_44614410_44614785 0.35 CRYAA
 crystallin, alpha A
 24331
 0.16
chr5_131596967_131597118 0.33 PDLIM4
 PDZ and LIM domain 4
 100
 0.96
chr2_235932870_235933072 0.33 SH3BP4
 SH3-domain binding protein 4
 29487
 0.26
chr15_75952983_75953304 0.33 SNX33
 sorting nexin 33
 11046
 0.09
chr6_169588623_169588774 0.33 XXyac-YX65C7_A.2
24651
 0.25
chr7_102006_102157 0.32 FAM20C
 family with sequence similarity 20, member C
 90888
 0.08
chr22_19950166_19950317 0.31 COMT
 catechol-O-methyltransferase
 171
 0.88
chr1_11978791_11978942 0.31 KIAA2013
 KIAA2013
 7614
 0.11
chr9_136009409_136009848 0.31 RALGDS
 ral guanine nucleotide dissociation stimulator
 3124
 0.19
chr2_151334939_151335090 0.31 RND3
 Rho family GTPase 3
 6882
 0.34
chr17_17641960_17642117 0.30 RAI1-AS1
 RAI1 antisense RNA 1
 32097
 0.12
chr11_126211364_126211625 0.30 ST3GAL4
 ST3 beta-galactoside alpha-2,3-sialyltransferase 4
 14061
 0.13
chr1_17559878_17560367 0.30 PADI1
 peptidyl arginine deiminase, type I
 272
 0.9
chr6_35393359_35394053 0.30 FANCE
 Fanconi anemia, complementation group E
 26432
 0.15
chr20_33905876_33906027 0.30 FAM83C
 family with sequence similarity 83, member C
 25747
 0.1
chr10_3134024_3134295 0.30 PFKP
 phosphofructokinase, platelet
 12757
 0.24
chr11_93642365_93642516 0.30 VSTM5
 V-set and transmembrane domain containing 5
 58743
 0.09
chr7_55152901_55153052 0.30 EGFR
 epidermal growth factor receptor
 24440
 0.25
chr19_11249778_11250050 0.29 SPC24
 SPC24, NDC80 kinetochore complex component
 16523
 0.12
chr10_36184776_36184927 0.29 FZD8
 frizzled family receptor 8
 254489
 0.02
chr10_60679631_60679782 0.29 ENSG00000252076
 .
 50762
 0.18
chr13_111100125_111100276 0.29 COL4A2-AS2
 COL4A2 antisense RNA 2
 15434
 0.2
chr1_68175974_68176125 0.29 GADD45A
 growth arrest and DNA-damage-inducible, alpha
 25165
 0.19
chr11_131942870_131943021 0.28 RP11-697E14.2
88390
 0.1
chr2_153429615_153429827 0.28 FMNL2
 formin-like 2
 46371
 0.19
chr20_40153797_40153948 0.28 CHD6
 chromodomain helicase DNA binding protein 6
 25915
 0.24
chr17_5689078_5689229 0.28 WSCD1
 WSC domain containing 1
 12907
 0.28
chr7_47641377_47641730 0.28 TNS3
 tensin 3
 19397
 0.24
chr3_49841571_49842107 0.27 FAM212A
 family with sequence similarity 212, member A
 1152
 0.26
chr1_157988308_157988459 0.27 KIRREL-IT1
 KIRREL intronic transcript 1 (non-protein coding)
 6957
 0.23
chr2_122405151_122406002 0.27 CLASP1
 cytoplasmic linker associated protein 1
 1476
 0.32
chr2_114086968_114087119 0.27 PAX8
 paired box 8
 50516
 0.11
chr1_94791983_94792377 0.27 ARHGAP29
 Rho GTPase activating protein 29
 88991
 0.08
chr11_82707430_82707581 0.26 RAB30
 RAB30, member RAS oncogene family
 950
 0.55
chr13_97958770_97958921 0.26 MBNL2
 muscleblind-like splicing regulator 2
 30387
 0.21
chr6_52415799_52415950 0.26 TRAM2
 translocation associated membrane protein 2
 25839
 0.21
chrX_19716630_19716896 0.26 SH3KBP1
 SH3-domain kinase binding protein 1
 27647
 0.25
chr1_957501_957652 0.26 AGRN
 agrin
 2073
 0.15
chr6_3390417_3390568 0.26 SLC22A23
 solute carrier family 22, member 23
 49160
 0.15
chr7_107587879_107588030 0.26 CTB-13F3.1
5393
 0.21
chr6_56598121_56598272 0.25 DST
 dystonin
 52481
 0.16
chr6_150018396_150018597 0.25 LATS1
 large tumor suppressor kinase 1
 4994
 0.17
chrX_71494679_71495271 0.25 RPS4X
 ribosomal protein S4, X-linked
 2123
 0.24
chr4_40336375_40336526 0.25 CHRNA9
 cholinergic receptor, nicotinic, alpha 9 (neuronal)
 896
 0.64
chr2_161077947_161078098 0.25 ITGB6
 integrin, beta 6
 21207
 0.26
chr10_80685977_80686128 0.25 ZMIZ1-AS1
 ZMIZ1 antisense RNA 1
 36099
 0.22
chr1_85962794_85962945 0.25 DDAH1
 dimethylarginine dimethylaminohydrolase 1
 32042
 0.18
chr13_44842560_44842711 0.25 SERP2
 stress-associated endoplasmic reticulum protein family member 2
 105343
 0.06
chr15_75944580_75944731 0.25 SNX33
 sorting nexin 33
 2558
 0.14
chr14_90332534_90332685 0.25 EFCAB11
 EF-hand calcium binding domain 11
 88258
 0.08
chr10_75839590_75840110 0.25 VCL
 vinculin
 3384
 0.27
chr18_39341234_39341385 0.25 PIK3C3
 phosphatidylinositol 3-kinase, catalytic subunit type 3
 193862
 0.03
chr3_10018102_10018700 0.25 EMC3
 ER membrane protein complex subunit 3
 9965
 0.08
chr10_34817563_34817714 0.25 PARD3
 par-3 family cell polarity regulator
 101979
 0.08
chr1_117663273_117663424 0.25 TRIM45
 tripartite motif containing 45
 1002
 0.52
chr6_18023428_18023579 0.25 KIF13A
 kinesin family member 13A
 35649
 0.19
chr18_60829223_60829856 0.24 RP11-299P2.1
10986
 0.23
chr2_109858418_109858699 0.24 ENSG00000265965
 .
 71523
 0.12
chr22_46502377_46502538 0.24 ENSG00000198986
 .
 6172
 0.1
chr1_161058674_161058838 0.24 PVRL4
 poliovirus receptor-related 4
 633
 0.46
chr2_150850695_150850846 0.24 ENSG00000207270
 .
 383482
 0.01
chr20_37055414_37055565 0.24 ENSG00000225091
 .
 596
 0.49
chr10_112113998_112114204 0.24 SMNDC1
 survival motor neuron domain containing 1
 49392
 0.14
chr16_83859962_83860113 0.24 HSBP1
 heat shock factor binding protein 1
 18443
 0.15
chr9_117567236_117567387 0.24 TNFSF15
 tumor necrosis factor (ligand) superfamily, member 15
 1095
 0.57
chr17_6458348_6458499 0.24 PITPNM3
 PITPNM family member 3
 1357
 0.4
chr8_123139338_123139489 0.24 HAS2-AS1
 HAS2 antisense RNA 1
 485737
 0.01
chr12_27768637_27769056 0.24 PPFIBP1
 PTPRF interacting protein, binding protein 1 (liprin beta 1)
 16565
 0.2
chr5_54734133_54734284 0.24 SKIV2L2
 superkiller viralicidic activity 2-like 2 (S. cerevisiae)
 22324
 0.2
chr22_38706278_38706454 0.23 CSNK1E
 casein kinase 1, epsilon
 6612
 0.15
chr2_19340414_19340714 0.23 ENSG00000266738
 .
 207626
 0.03
chr13_43841739_43841890 0.23 ENOX1
 ecto-NOX disulfide-thiol exchanger 1
 93399
 0.1
chr5_39072103_39073220 0.23 RICTOR
 RPTOR independent companion of MTOR, complex 2
 1830
 0.43
chr3_65840431_65840582 0.23 MAGI1-AS1
 MAGI1 antisense RNA 1
 38985
 0.19
chr15_67391659_67392162 0.23 SMAD3
 SMAD family member 3
 893
 0.69
chr2_197200671_197200822 0.23 HECW2
 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
 26200
 0.19
chr1_66727440_66727741 0.23 PDE4B
 phosphodiesterase 4B, cAMP-specific
 4260
 0.35
chr8_77710984_77711275 0.23 ZFHX4
 zinc finger homeobox 4
 94849
 0.08
chr10_121486459_121486910 0.23 INPP5F
 inositol polyphosphate-5-phosphatase F
 1075
 0.58
chr7_18560218_18560369 0.23 HDAC9
 histone deacetylase 9
 11357
 0.29
chr2_36630762_36630913 0.23 CRIM1
 cysteine rich transmembrane BMP regulator 1 (chordin-like)
 47223
 0.18
chr2_47496531_47496728 0.23 EPCAM
 epithelial cell adhesion molecule
 75668
 0.08
chr15_77765751_77766016 0.23 HMG20A
 high mobility group 20A
 4752
 0.29
chr6_157097585_157098248 0.23 ARID1B
 AT rich interactive domain 1B (SWI1-like)
 1147
 0.47
chr7_107580682_107580917 0.23 CTB-13F3.1
1762
 0.37
chr1_223914687_223915020 0.23 CAPN2
 calpain 2, (m/II) large subunit
 14819
 0.21
chr3_170442792_170442943 0.22 RP11-373E16.3
68516
 0.11
chr6_142335066_142335264 0.22 RP11-137J7.2
74205
 0.1
chr2_54556871_54557022 0.22 C2orf73
 chromosome 2 open reading frame 73
 225
 0.96
chr22_45999416_45999868 0.22 CTA-941F9.9
1859
 0.36
chr5_72248272_72248423 0.22 FCHO2
 FCH domain only 2
 3461
 0.29
chr7_73437685_73437836 0.22 ELN
 elastin
 4359
 0.23
chr10_120783426_120783577 0.22 NANOS1
 nanos homolog 1 (Drosophila)
 5727
 0.15
chr19_19448791_19448942 0.22 MAU2
 MAU2 sister chromatid cohesion factor
 851
 0.51
chr2_113561475_113561741 0.22 IL1A
 interleukin 1, alpha
 19441
 0.15
chr3_184053305_184053591 0.22 FAM131A
 family with sequence similarity 131, member A
 266
 0.83
chr10_97021204_97021355 0.22 PDLIM1
 PDZ and LIM domain 1
 29502
 0.17
chr5_34489326_34489477 0.22 RAI14
 retinoic acid induced 14
 166941
 0.03
chr11_95563091_95563245 0.22 ENSG00000222578
 .
 10120
 0.2
chr3_159578988_159579165 0.22 SCHIP1
 schwannomin interacting protein 1
 8348
 0.21
chr11_82746781_82747055 0.22 RAB30
 RAB30, member RAS oncogene family
 182
 0.93
chr1_41951575_41951868 0.22 EDN2
 endothelin 2
 1379
 0.46
chr2_214102661_214102812 0.22 SPAG16
 sperm associated antigen 16
 46377
 0.19
chr9_116987160_116987311 0.22 ENSG00000207726
 .
 15521
 0.21
chr17_42872109_42872587 0.22 GJC1
 gap junction protein, gamma 1, 45kDa
 9986
 0.14
chr14_32729279_32729430 0.22 ENSG00000202337
 .
 56879
 0.12
chr11_92436620_92436809 0.22 ENSG00000239086
 .
 25867
 0.23
chr8_121668070_121668250 0.21 RP11-713M15.1
105333
 0.07
chr17_35208390_35208541 0.21 RP11-445F12.1
85456
 0.07
chr2_10637857_10638008 0.21 ODC1
 ornithine decarboxylase 1
 49302
 0.12
chr8_18924934_18925175 0.21 PSD3
 pleckstrin and Sec7 domain containing 3
 17186
 0.25
chr5_123287126_123287277 0.21 CSNK1G3
 casein kinase 1, gamma 3
 363082
 0.01
chr6_37672011_37672162 0.21 MDGA1
 MAM domain containing glycosylphosphatidylinositol anchor 1
 5004
 0.29
chr16_24682416_24682567 0.21 TNRC6A
 trinucleotide repeat containing 6A
 58525
 0.14
chr2_47075877_47076128 0.21 AC016722.3
4633
 0.18
chr6_43404132_43404283 0.21 ABCC10
 ATP-binding cassette, sub-family C (CFTR/MRP), member 10
 4718
 0.14
chr4_58015328_58015479 0.21 IGFBP7-AS1
 IGFBP7 antisense RNA 1
 29908
 0.16
chr6_117769723_117769874 0.21 ENSG00000221434
 .
 3245
 0.19
chr1_86072633_86072784 0.21 ENSG00000199934
 .
 14745
 0.19
chr17_79856737_79856888 0.21 NPB
 neuropeptide B
 1809
 0.12
chr17_786368_786519 0.21 RP11-676J12.6
5301
 0.17
chr17_30114922_30115222 0.21 COPRS
 coordinator of PRMT5, differentiation stimulator
 70878
 0.09
chr12_28241646_28241866 0.21 CCDC91
 coiled-coil domain containing 91
 44426
 0.17
chr2_192162047_192162336 0.21 MYO1B
 myosin IB
 20580
 0.24
chr16_73206720_73206871 0.21 C16orf47
 chromosome 16 open reading frame 47
 28449
 0.24
chr17_70389634_70389785 0.21 ENSG00000200783
 .
 270582
 0.02
chr10_25356907_25357058 0.21 ENSG00000266069
 .
 23501
 0.18
chr5_81691859_81692010 0.21 ATP6AP1L
 ATPase, H+ transporting, lysosomal accessory protein 1-like
 90768
 0.09
chr2_191701675_191701826 0.21 GLS
 glutaminase
 43803
 0.15
chr17_73680379_73680530 0.21 RP11-474I11.7
332
 0.78
chr3_184458230_184458452 0.21 MAGEF1
 melanoma antigen family F, 1
 28505
 0.21
chr12_125004763_125004951 0.20 NCOR2
 nuclear receptor corepressor 2
 2017
 0.48
chr14_77769480_77769631 0.20 POMT2
 protein-O-mannosyltransferase 2
 17128
 0.12
chr3_55225338_55225489 0.20 LRTM1
 leucine-rich repeats and transmembrane domains 1
 224298
 0.02
chr10_34812193_34812344 0.20 PARD3
 par-3 family cell polarity regulator
 96609
 0.09
chr8_99252680_99252831 0.20 ENSG00000252558
 .
 48214
 0.13
chr10_99334275_99334487 0.20 ANKRD2
 ankyrin repeat domain 2 (stretch responsive muscle)
 1845
 0.23
chr3_134190527_134190678 0.20 CEP63
 centrosomal protein 63kDa
 13983
 0.17
chr9_16530797_16530948 0.20 RP11-183I6.2
57686
 0.14
chr2_45926277_45926449 0.20 U51244.2
23748
 0.22
chr2_65528456_65529216 0.20 SPRED2
 sprouty-related, EVH1 domain containing 2
 33071
 0.18
chr20_45964041_45964253 0.20 ZMYND8
 zinc finger, MYND-type containing 8
 12669
 0.12
chr14_99730566_99730874 0.20 AL109767.1
1435
 0.45
chr9_134544593_134545249 0.20 RAPGEF1
 Rap guanine nucleotide exchange factor (GEF) 1
 40308
 0.16
chr21_39159638_39159789 0.20 KCNJ6-IT1
 KCNJ6 intronic transcript 1 (non-protein coding)
 67841
 0.12
chr11_209951_210389 0.20 RIC8A
 RIC8 guanine nucleotide exchange factor A
 540
 0.56
chr12_10870616_10870767 0.20 YBX3
 Y box binding protein 3
 5215
 0.19
chr5_102094172_102094323 0.20 PAM
 peptidylglycine alpha-amidating monooxygenase
 3200
 0.4
chr15_85198433_85198643 0.20 WDR73
 WD repeat domain 73
 972
 0.38
chr4_186759888_186760109 0.20 SORBS2
 sorbin and SH3 domain containing 2
 25720
 0.22
chr5_73929418_73929569 0.20 HEXB
 hexosaminidase B (beta polypeptide)
 6355
 0.22
chr7_101542873_101543024 0.20 CTB-181H17.1
60448
 0.12
chr12_67973360_67973731 0.20 DYRK2
 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
 68573
 0.13
chr10_127750733_127750884 0.20 FANK1
 fibronectin type III and ankyrin repeat domains 1
 66822
 0.11
chr3_58028586_58028737 0.20 FLNB
 filamin B, beta
 34534
 0.2
chr12_125008473_125008624 0.20 NCOR2
 nuclear receptor corepressor 2
 5708
 0.33
chr2_172734754_172734905 0.20 SLC25A12
 solute carrier family 25 (aspartate/glutamate carrier), member 12
 15904
 0.18
chr8_144351405_144351556 0.20 GLI4
 GLI family zinc finger 4
 48
 0.95
chr19_7994500_7994751 0.20 TIMM44
 translocase of inner mitochondrial membrane 44 homolog (yeast)
 3006
 0.09
chr10_49705076_49705298 0.19 ARHGAP22
 Rho GTPase activating protein 22
 3495
 0.27
chr15_99433869_99434228 0.19 IGF1R
 insulin-like growth factor 1 receptor
 478
 0.81
chr15_75943289_75943440 0.19 SNX33
 sorting nexin 33
 1267
 0.26
chr12_680340_680491 0.19 RP5-1154L15.2
15237
 0.13
chr3_112938618_112938769 0.19 BOC
 BOC cell adhesion associated, oncogene regulated
 3495
 0.28
chr10_4283369_4283520 0.19 ENSG00000207124
 .
 273700
 0.02
chr12_13355141_13355292 0.19 EMP1
 epithelial membrane protein 1
 5496
 0.28
chr19_47032971_47033122 0.19 PNMAL2
 paraneoplastic Ma antigen family-like 2
 33291
 0.1
chr3_135686478_135686629 0.19 PPP2R3A
 protein phosphatase 2, regulatory subunit B'', alpha
 1967
 0.48
chr3_23260755_23260906 0.19 UBE2E2
 ubiquitin-conjugating enzyme E2E 2
 16046
 0.21
chr16_70739971_70740122 0.19 VAC14
 Vac14 homolog (S. cerevisiae)
 5898
 0.15
chr4_143323741_143324372 0.19 INPP4B
 inositol polyphosphate-4-phosphatase, type II, 105kDa
 28356
 0.27
chr11_12808922_12809073 0.19 RP11-47J17.3
36217
 0.16
chr3_45022029_45022244 0.19 EXOSC7
 exosome component 7
 4414
 0.18
chr2_218798437_218798606 0.19 TNS1
 tensin 1
 3364
 0.29
chr1_157013189_157013361 0.19 ARHGEF11
 Rho guanine nucleotide exchange factor (GEF) 11
 1590
 0.4
chr13_102051061_102051212 0.19 NALCN
 sodium leak channel, non-selective
 369
 0.92
chr8_119092018_119092169 0.19 EXT1
 exostosin glycosyltransferase 1
 30560
 0.26
chr20_10553626_10553777 0.19 JAG1
 jagged 1
 89453
 0.08
chr6_140064279_140064430 0.19 CITED2
 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
 368597
 0.01
chr6_151384328_151384479 0.19 RP1-292B18.3
7210
 0.2
chr16_73080354_73080613 0.19 ZFHX3
 zinc finger homeobox 3
 1791
 0.4
chr6_147212341_147212492 0.19 STXBP5-AS1
 STXBP5 antisense RNA 1
 20326
 0.27
chr13_111152177_111152328 0.19 COL4A2-AS1
 COL4A2 antisense RNA 1
 8274
 0.21
chr11_11605697_11605905 0.19 RP11-483L5.1
14170
 0.22
chr2_65548092_65548243 0.19 SPRED2
 sprouty-related, EVH1 domain containing 2
 13740
 0.24
chr3_149161433_149161643 0.19 TM4SF4
 transmembrane 4 L six family member 4
 30223
 0.16
chr14_96721657_96721808 0.19 BDKRB1
 bradykinin receptor B1
 429
 0.75
chr17_7745682_7745903 0.19 KDM6B
 lysine (K)-specific demethylase 6B
 2441
 0.15
chr5_98122643_98122794 0.19 RGMB
 repulsive guidance molecule family member b
 13379
 0.22
chr18_56248505_56248656 0.19 ENSG00000252284
 .
 19283
 0.14
chr3_18279258_18279409 0.19 RP11-158G18.1
171794
 0.04
chr1_178501668_178501871 0.19 C1orf220
 chromosome 1 open reading frame 220
 10118
 0.15
chr20_50806700_50806851 0.19 ZFP64
 ZFP64 zinc finger protein
 1461
 0.59
chr17_66179467_66179660 0.19 LRRC37A16P
 leucine rich repeat containing 37, member A16, pseudogene
 30954
 0.15
chr8_89288165_89288316 0.19 RP11-586K2.1
50825
 0.16

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of SIX4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0044415 evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.1 0.3 GO:0051176 positive regulation of sulfur metabolic process(GO:0051176)
0.1 0.2 GO:0051497 negative regulation of stress fiber assembly(GO:0051497)
0.1 0.2 GO:0010193 response to ozone(GO:0010193)
0.1 0.2 GO:0060743 epithelial cell maturation involved in prostate gland development(GO:0060743)
0.0 0.1 GO:0003099 positive regulation of the force of heart contraction by chemical signal(GO:0003099)
0.0 0.1 GO:0046813 receptor-mediated virion attachment to host cell(GO:0046813)
0.0 0.1 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 0.4 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
0.0 0.3 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
0.0 0.2 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.0 0.2 GO:0016246 RNA interference(GO:0016246)
0.0 0.1 GO:0010511 regulation of phosphatidylinositol biosynthetic process(GO:0010511)
0.0 0.2 GO:0071731 response to nitric oxide(GO:0071731)
0.0 0.1 GO:0045085 negative regulation of interleukin-2 biosynthetic process(GO:0045085)
0.0 0.1 GO:0018101 protein citrullination(GO:0018101)
0.0 0.2 GO:0060390 regulation of SMAD protein import into nucleus(GO:0060390)
0.0 0.1 GO:0070141 response to UV-A(GO:0070141)
0.0 0.1 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.0 0.1 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.0 0.1 GO:0043374 CD8-positive, alpha-beta T cell activation(GO:0036037) CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0 0.0 GO:0001996 positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996)
0.0 0.1 GO:0071364 cellular response to epidermal growth factor stimulus(GO:0071364)
0.0 0.2 GO:0043922 negative regulation by host of viral transcription(GO:0043922)
0.0 0.1 GO:0007000 nucleolus organization(GO:0007000)
0.0 0.1 GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.0 0.1 GO:0009128 purine nucleoside monophosphate catabolic process(GO:0009128) ribonucleoside monophosphate catabolic process(GO:0009158) purine ribonucleoside monophosphate catabolic process(GO:0009169)
0.0 0.1 GO:0040016 embryonic cleavage(GO:0040016)
0.0 0.1 GO:0006065 UDP-glucuronate biosynthetic process(GO:0006065)
0.0 0.1 GO:0061303 cornea development in camera-type eye(GO:0061303)
0.0 0.1 GO:0031223 auditory behavior(GO:0031223)
0.0 0.1 GO:0010761 fibroblast migration(GO:0010761)
0.0 0.1 GO:0021834 chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration(GO:0021834)
0.0 0.0 GO:0003057 regulation of the force of heart contraction by chemical signal(GO:0003057)
0.0 0.1 GO:0060296 regulation of cilium movement(GO:0003352) regulation of cilium beat frequency(GO:0003356) cilium movement involved in cell motility(GO:0060294) regulation of cilium movement involved in cell motility(GO:0060295) regulation of cilium beat frequency involved in ciliary motility(GO:0060296) regulation of cilium-dependent cell motility(GO:1902019)
0.0 0.1 GO:0045721 negative regulation of gluconeogenesis(GO:0045721)
0.0 0.1 GO:0019934 cGMP-mediated signaling(GO:0019934)
0.0 0.1 GO:0042668 auditory receptor cell fate determination(GO:0042668)
0.0 0.0 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.0 0.1 GO:0000052 citrulline metabolic process(GO:0000052)
0.0 0.1 GO:0072047 proximal/distal pattern formation involved in nephron development(GO:0072047) specification of nephron tubule identity(GO:0072081)
0.0 0.1 GO:0006772 thiamine metabolic process(GO:0006772)
0.0 0.1 GO:0060999 positive regulation of dendritic spine development(GO:0060999)
0.0 0.0 GO:0010936 negative regulation of macrophage cytokine production(GO:0010936)
0.0 0.2 GO:0033137 negative regulation of peptidyl-serine phosphorylation(GO:0033137)
0.0 0.1 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.0 0.1 GO:0070874 negative regulation of glycogen metabolic process(GO:0070874)
0.0 0.1 GO:0010766 negative regulation of sodium ion transport(GO:0010766)
0.0 0.3 GO:0035329 hippo signaling(GO:0035329)
0.0 0.1 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.0 0.1 GO:0031639 plasminogen activation(GO:0031639)
0.0 0.0 GO:0051877 pigment granule aggregation in cell center(GO:0051877)
0.0 0.1 GO:0043578 nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0 0.1 GO:0060831 smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:0060831)
0.0 0.1 GO:0060732 positive regulation of inositol phosphate biosynthetic process(GO:0060732)
0.0 0.1 GO:0060648 mammary gland bud morphogenesis(GO:0060648)
0.0 0.0 GO:0009448 gamma-aminobutyric acid metabolic process(GO:0009448)
0.0 0.1 GO:0019919 peptidyl-arginine methylation, to asymmetrical-dimethyl arginine(GO:0019919)
0.0 0.2 GO:0050974 detection of mechanical stimulus involved in sensory perception(GO:0050974)
0.0 0.1 GO:0060174 limb bud formation(GO:0060174)
0.0 0.1 GO:0003197 endocardial cushion development(GO:0003197)
0.0 0.1 GO:0051124 synaptic growth at neuromuscular junction(GO:0051124)
0.0 0.0 GO:0048807 female genitalia morphogenesis(GO:0048807)
0.0 0.0 GO:0050765 negative regulation of phagocytosis(GO:0050765)
0.0 0.0 GO:0061029 eyelid development in camera-type eye(GO:0061029)
0.0 0.0 GO:0072393 microtubule anchoring at microtubule organizing center(GO:0072393)
0.0 0.0 GO:0071681 response to indole-3-methanol(GO:0071680) cellular response to indole-3-methanol(GO:0071681)
0.0 0.1 GO:0032693 negative regulation of interleukin-10 production(GO:0032693)
0.0 0.0 GO:0006166 purine ribonucleoside salvage(GO:0006166)
0.0 0.1 GO:0010891 negative regulation of sequestering of triglyceride(GO:0010891)
0.0 0.1 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 0.1 GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway(GO:0040037)
0.0 0.1 GO:0048745 smooth muscle tissue development(GO:0048745)
0.0 0.2 GO:0017187 peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214)
0.0 0.2 GO:0007413 axonal fasciculation(GO:0007413)
0.0 0.0 GO:0048845 venous blood vessel morphogenesis(GO:0048845)
0.0 0.1 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
0.0 0.0 GO:0046121 deoxyribonucleoside catabolic process(GO:0046121)
0.0 0.1 GO:0000090 mitotic anaphase(GO:0000090)
0.0 0.1 GO:0060840 artery development(GO:0060840)
0.0 0.1 GO:0000729 DNA double-strand break processing(GO:0000729)
0.0 0.0 GO:0060083 smooth muscle contraction involved in micturition(GO:0060083)
0.0 0.0 GO:0031657 regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle(GO:0031657) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle(GO:0031659)
0.0 0.0 GO:0009106 lipoate metabolic process(GO:0009106)
0.0 0.0 GO:0071071 regulation of phospholipid biosynthetic process(GO:0071071)
0.0 0.0 GO:0070427 nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427)
0.0 0.0 GO:0009151 purine deoxyribonucleotide metabolic process(GO:0009151)
0.0 0.2 GO:0007020 microtubule nucleation(GO:0007020)
0.0 0.2 GO:0007567 parturition(GO:0007567)
0.0 0.0 GO:0007598 blood coagulation, extrinsic pathway(GO:0007598)
0.0 0.1 GO:0071320 cellular response to cAMP(GO:0071320)
0.0 0.0 GO:0016999 antibiotic metabolic process(GO:0016999) antibiotic biosynthetic process(GO:0017000)
0.0 0.0 GO:0048702 embryonic neurocranium morphogenesis(GO:0048702)
0.0 0.1 GO:0009200 deoxyribonucleoside triphosphate metabolic process(GO:0009200)
0.0 0.1 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.0 0.2 GO:0032964 collagen biosynthetic process(GO:0032964)
0.0 0.0 GO:0043497 regulation of protein heterodimerization activity(GO:0043497)
0.0 0.0 GO:0033087 negative regulation of immature T cell proliferation(GO:0033087) negative regulation of immature T cell proliferation in thymus(GO:0033088)
0.0 0.0 GO:0060009 Sertoli cell development(GO:0060009)
0.0 0.1 GO:0033089 positive regulation of T cell differentiation in thymus(GO:0033089) positive regulation of thymocyte aggregation(GO:2000400)
0.0 0.0 GO:2000054 negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000054)
0.0 0.0 GO:2000050 regulation of non-canonical Wnt signaling pathway(GO:2000050)
0.0 0.1 GO:0032926 negative regulation of activin receptor signaling pathway(GO:0032926)
0.0 0.1 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.0 0.1 GO:0003310 pancreatic A cell differentiation(GO:0003310)
0.0 0.0 GO:0033688 regulation of osteoblast proliferation(GO:0033688)
0.0 0.0 GO:0001957 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.0 0.0 GO:0050703 interleukin-1 alpha secretion(GO:0050703)
0.0 0.0 GO:0031558 obsolete induction of apoptosis in response to chemical stimulus(GO:0031558)
0.0 0.0 GO:0060059 Wnt signaling pathway involved in dorsal/ventral axis specification(GO:0044332) embryonic retina morphogenesis in camera-type eye(GO:0060059) regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000053)
0.0 0.1 GO:0032691 negative regulation of interleukin-1 beta production(GO:0032691)
0.0 0.1 GO:0043508 negative regulation of JUN kinase activity(GO:0043508)
0.0 0.3 GO:0030199 collagen fibril organization(GO:0030199)
0.0 0.1 GO:0046952 ketone body catabolic process(GO:0046952)
0.0 0.0 GO:0045627 positive regulation of T-helper 1 cell differentiation(GO:0045627)
0.0 0.2 GO:0048286 lung alveolus development(GO:0048286)
0.0 0.1 GO:0072383 plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.0 0.1 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.0 0.0 GO:0048861 leukemia inhibitory factor signaling pathway(GO:0048861)
0.0 0.1 GO:0051492 regulation of stress fiber assembly(GO:0051492)
0.0 0.0 GO:0061101 neuroendocrine cell differentiation(GO:0061101)
0.0 0.0 GO:0035581 sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.0 0.1 GO:0061088 regulation of sequestering of zinc ion(GO:0061088)
0.0 0.1 GO:0006546 glycine catabolic process(GO:0006546)
0.0 0.0 GO:0009912 auditory receptor cell fate commitment(GO:0009912) inner ear receptor cell fate commitment(GO:0060120)
0.0 0.0 GO:0071502 cellular response to temperature stimulus(GO:0071502)
0.0 0.0 GO:0050916 sensory perception of sweet taste(GO:0050916)
0.0 0.0 GO:0072048 pattern specification involved in kidney development(GO:0061004) renal system pattern specification(GO:0072048)
0.0 0.1 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.0 0.0 GO:0007207 phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.0 0.0 GO:0048843 negative regulation of axon extension involved in axon guidance(GO:0048843) negative regulation of axon guidance(GO:1902668)
0.0 0.0 GO:0048859 formation of anatomical boundary(GO:0048859)
0.0 0.0 GO:2000272 negative regulation of ion transmembrane transporter activity(GO:0032413) negative regulation of release of sequestered calcium ion into cytosol(GO:0051280) positive regulation of sequestering of calcium ion(GO:0051284) negative regulation of calcium ion transmembrane transport(GO:1903170) negative regulation of receptor activity(GO:2000272)
0.0 0.0 GO:0050982 detection of mechanical stimulus(GO:0050982)
0.0 0.1 GO:0007520 myoblast fusion(GO:0007520)
0.0 0.1 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.0 0.1 GO:0002087 regulation of respiratory gaseous exchange by neurological system process(GO:0002087)
0.0 0.0 GO:0072367 regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367)
0.0 0.3 GO:0006493 protein O-linked glycosylation(GO:0006493)
0.0 0.0 GO:0055098 response to low-density lipoprotein particle(GO:0055098)
0.0 0.0 GO:1903521 apoptotic process involved in mammary gland involution(GO:0060057) positive regulation of apoptotic process involved in mammary gland involution(GO:0060058) positive regulation of apoptotic process involved in morphogenesis(GO:1902339) regulation of mammary gland involution(GO:1903519) positive regulation of mammary gland involution(GO:1903521) positive regulation of apoptotic process involved in development(GO:1904747)
0.0 0.1 GO:0021527 spinal cord association neuron differentiation(GO:0021527)
0.0 0.0 GO:0010834 obsolete telomere maintenance via telomere shortening(GO:0010834)
0.0 0.0 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
0.0 0.1 GO:0006534 cysteine metabolic process(GO:0006534)
0.0 0.0 GO:0034088 maintenance of sister chromatid cohesion(GO:0034086) maintenance of mitotic sister chromatid cohesion(GO:0034088)
0.0 0.0 GO:0042268 regulation of cytolysis(GO:0042268)
0.0 0.0 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.0 0.0 GO:0046501 protoporphyrinogen IX metabolic process(GO:0046501)
0.0 0.0 GO:0051503 adenine nucleotide transport(GO:0051503)
0.0 0.0 GO:0045715 negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715)
0.0 0.0 GO:0006104 succinyl-CoA metabolic process(GO:0006104)
0.0 0.0 GO:0060129 thyroid-stimulating hormone-secreting cell differentiation(GO:0060129)
0.0 0.0 GO:0060662 tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662)
0.0 0.2 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
0.0 0.1 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0 0.0 GO:0034629 cellular protein complex localization(GO:0034629)
0.0 0.0 GO:0032817 regulation of natural killer cell proliferation(GO:0032817)
0.0 0.0 GO:0014832 urinary bladder smooth muscle contraction(GO:0014832) urinary tract smooth muscle contraction(GO:0014848)
0.0 0.0 GO:0006591 ornithine metabolic process(GO:0006591)
0.0 0.0 GO:0007501 mesodermal cell fate specification(GO:0007501)
0.0 0.0 GO:0031065 positive regulation of histone deacetylation(GO:0031065)
0.0 0.0 GO:0006172 ADP biosynthetic process(GO:0006172) purine nucleoside diphosphate biosynthetic process(GO:0009136) purine ribonucleoside diphosphate biosynthetic process(GO:0009180) ribonucleoside diphosphate biosynthetic process(GO:0009188)
0.0 0.0 GO:0006526 arginine biosynthetic process(GO:0006526)
0.0 0.0 GO:0070837 dehydroascorbic acid transport(GO:0070837)
0.0 0.0 GO:0045046 protein import into peroxisome membrane(GO:0045046)
0.0 0.0 GO:0030488 tRNA methylation(GO:0030488)
0.0 0.0 GO:0010842 retina layer formation(GO:0010842)
0.0 0.1 GO:0009649 entrainment of circadian clock(GO:0009649)
0.0 0.3 GO:0003333 amino acid transmembrane transport(GO:0003333)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0005594 collagen type IX trimer(GO:0005594)
0.0 0.1 GO:0005593 FACIT collagen trimer(GO:0005593)
0.0 0.1 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0 0.1 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.0 0.1 GO:0031932 TORC2 complex(GO:0031932)
0.0 0.2 GO:0005587 collagen type IV trimer(GO:0005587)
0.0 0.1 GO:0071062 alphav-beta3 integrin-vitronectin complex(GO:0071062)
0.0 0.1 GO:0001527 microfibril(GO:0001527)
0.0 0.1 GO:0005588 collagen type V trimer(GO:0005588)
0.0 0.1 GO:0005828 kinetochore microtubule(GO:0005828)
0.0 0.1 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.1 GO:0002080 acrosomal membrane(GO:0002080)
0.0 0.1 GO:0031371 ubiquitin conjugating enzyme complex(GO:0031371)
0.0 0.0 GO:0098645 network-forming collagen trimer(GO:0098642) collagen network(GO:0098645)
0.0 0.2 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.1 GO:0008290 F-actin capping protein complex(GO:0008290)
0.0 0.1 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.0 0.1 GO:0043083 synaptic cleft(GO:0043083)
0.0 0.1 GO:0018995 host(GO:0018995) host cell part(GO:0033643) host intracellular part(GO:0033646) intracellular region of host(GO:0043656) host cell(GO:0043657) other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217)
0.0 0.0 GO:0071664 catenin-TCF7L2 complex(GO:0071664)
0.0 0.1 GO:0042825 TAP complex(GO:0042825)
0.0 0.1 GO:0032059 bleb(GO:0032059)
0.0 0.1 GO:0016342 catenin complex(GO:0016342)
0.0 0.1 GO:0000214 tRNA-intron endonuclease complex(GO:0000214)
0.0 0.1 GO:0043259 laminin-10 complex(GO:0043259)
0.0 0.1 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.1 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
0.0 0.4 GO:0005637 nuclear inner membrane(GO:0005637)
0.0 0.0 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 0.2 GO:0016514 SWI/SNF complex(GO:0016514)
0.0 0.4 GO:0097517 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 0.1 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.0 0.0 GO:0043205 fibril(GO:0043205)
0.0 0.1 GO:0071204 histone pre-mRNA 3'end processing complex(GO:0071204)
0.0 0.0 GO:0042405 nuclear inclusion body(GO:0042405)
0.0 0.1 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.0 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.0 0.1 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.0 0.1 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.0 0.0 GO:0098651 basement membrane collagen trimer(GO:0098651)
0.0 0.1 GO:0030669 clathrin-coated endocytic vesicle membrane(GO:0030669)
0.0 0.2 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 0.1 GO:0031332 RISC complex(GO:0016442) RNAi effector complex(GO:0031332)
0.0 0.0 GO:0032449 CBM complex(GO:0032449)
0.0 0.0 GO:0042629 mast cell granule(GO:0042629)
0.0 0.0 GO:0000124 SAGA complex(GO:0000124)
0.0 0.0 GO:0000164 protein phosphatase type 1 complex(GO:0000164)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.1 0.3 GO:0005010 insulin-like growth factor-activated receptor activity(GO:0005010)
0.1 0.2 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.1 0.3 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.1 0.2 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.0 0.1 GO:0016842 amidine-lyase activity(GO:0016842)
0.0 0.4 GO:0017166 vinculin binding(GO:0017166)
0.0 0.1 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.0 0.1 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.0 0.1 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.0 0.1 GO:0004668 protein-arginine deiminase activity(GO:0004668)
0.0 0.1 GO:0003872 6-phosphofructokinase activity(GO:0003872)
0.0 0.1 GO:0048018 receptor agonist activity(GO:0048018)
0.0 0.1 GO:0043515 kinetochore binding(GO:0043515)
0.0 0.3 GO:0005112 Notch binding(GO:0005112)
0.0 0.1 GO:0031705 bombesin receptor binding(GO:0031705) endothelin B receptor binding(GO:0031708)
0.0 0.2 GO:0030020 extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.0 0.1 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0 0.1 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 0.1 GO:0050508 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.0 0.2 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 0.1 GO:0032190 acrosin binding(GO:0032190)
0.0 0.1 GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847)
0.0 0.1 GO:0004775 succinate-CoA ligase (ADP-forming) activity(GO:0004775)
0.0 0.1 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0 0.1 GO:0097493 extracellular matrix constituent conferring elasticity(GO:0030023) structural molecule activity conferring elasticity(GO:0097493)
0.0 0.0 GO:0043125 ErbB-3 class receptor binding(GO:0043125)
0.0 0.1 GO:0046980 tapasin binding(GO:0046980)
0.0 0.1 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.0 0.1 GO:0004311 farnesyltranstransferase activity(GO:0004311)
0.0 0.2 GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0000982) transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 0.2 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 0.2 GO:0050811 GABA receptor binding(GO:0050811)
0.0 0.1 GO:0070696 transmembrane receptor protein serine/threonine kinase binding(GO:0070696)
0.0 0.2 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.0 0.1 GO:0030506 ankyrin binding(GO:0030506)
0.0 0.1 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.0 0.2 GO:0042605 peptide antigen binding(GO:0042605)
0.0 0.1 GO:0004908 interleukin-1 receptor activity(GO:0004908)
0.0 0.1 GO:0030548 acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
0.0 0.1 GO:0004470 malic enzyme activity(GO:0004470)
0.0 0.1 GO:0048495 Roundabout binding(GO:0048495)
0.0 0.1 GO:0004924 oncostatin-M receptor activity(GO:0004924)
0.0 0.2 GO:0005123 death receptor binding(GO:0005123)
0.0 0.1 GO:0070569 uridylyltransferase activity(GO:0070569)
0.0 0.1 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.0 0.1 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.0 0.1 GO:0050253 retinyl-palmitate esterase activity(GO:0050253)
0.0 0.1 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 0.1 GO:0004937 alpha1-adrenergic receptor activity(GO:0004937)
0.0 0.2 GO:0004065 arylsulfatase activity(GO:0004065)
0.0 0.2 GO:0032393 MHC class I receptor activity(GO:0032393)
0.0 0.2 GO:0008171 O-methyltransferase activity(GO:0008171)
0.0 0.1 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 0.1 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.1 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.0 0.1 GO:0035241 protein-arginine omega-N monomethyltransferase activity(GO:0035241)
0.0 0.1 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.0 0.1 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.0 0.0 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.1 GO:0050815 phosphoserine binding(GO:0050815)
0.0 0.1 GO:0030172 troponin C binding(GO:0030172)
0.0 0.0 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 0.0 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.1 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.0 0.0 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017)
0.0 0.0 GO:0033765 steroid dehydrogenase activity, acting on the CH-CH group of donors(GO:0033765)
0.0 0.0 GO:0005294 neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.0 0.3 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 0.1 GO:0045502 dynein binding(GO:0045502)
0.0 0.1 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.0 0.0 GO:0004117 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117)
0.0 0.1 GO:0030332 cyclin binding(GO:0030332)
0.0 0.1 GO:0005138 interleukin-6 receptor binding(GO:0005138)
0.0 0.1 GO:0005355 glucose transmembrane transporter activity(GO:0005355)
0.0 0.0 GO:0051734 ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734)
0.0 0.0 GO:0070996 type 1 melanocortin receptor binding(GO:0070996)
0.0 0.1 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.0 0.1 GO:0048185 activin binding(GO:0048185)
0.0 0.3 GO:0019003 GDP binding(GO:0019003)
0.0 0.0 GO:0043024 ribosomal small subunit binding(GO:0043024)
0.0 0.0 GO:0050693 LBD domain binding(GO:0050693)
0.0 0.1 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.1 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.0 0.1 GO:0016595 glutamate binding(GO:0016595)
0.0 0.2 GO:0004016 adenylate cyclase activity(GO:0004016)
0.0 0.0 GO:0050698 proteoglycan sulfotransferase activity(GO:0050698)
0.0 0.0 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.0 0.1 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 0.1 GO:0001871 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0 0.0 GO:0015142 citrate transmembrane transporter activity(GO:0015137) tricarboxylic acid transmembrane transporter activity(GO:0015142)
0.0 0.1 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0 0.1 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.0 0.0 GO:0031127 galactoside 2-alpha-L-fucosyltransferase activity(GO:0008107) alpha-(1,2)-fucosyltransferase activity(GO:0031127)
0.0 0.1 GO:0005110 frizzled-2 binding(GO:0005110)
0.0 0.1 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.0 GO:0055103 ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106)
0.0 0.0 GO:0000309 nicotinamide-nucleotide adenylyltransferase activity(GO:0000309) nicotinate-nucleotide adenylyltransferase activity(GO:0004515)
0.0 0.0 GO:0042577 lipid phosphatase activity(GO:0042577)
0.0 0.1 GO:0003691 double-stranded telomeric DNA binding(GO:0003691)
0.0 0.0 GO:0004103 choline kinase activity(GO:0004103)
0.0 0.0 GO:0019166 trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166)
0.0 0.0 GO:0043559 insulin binding(GO:0043559)
0.0 0.0 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.0 0.1 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0 0.1 GO:0042171 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) lysophosphatidic acid acyltransferase activity(GO:0042171) lysophospholipid acyltransferase activity(GO:0071617)
0.0 0.1 GO:0017110 nucleoside-diphosphatase activity(GO:0017110)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 PID REELIN PATHWAY Reelin signaling pathway
0.0 0.5 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.0 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 0.1 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway
0.0 0.3 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.4 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.0 0.0 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.0 0.1 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.0 0.4 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.3 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.0 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.0 0.1 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.0 0.0 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.0 0.8 PID AVB3 INTEGRIN PATHWAY Integrins in angiogenesis
0.0 0.0 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 0.5 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 0.1 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 0.3 PID IL1 PATHWAY IL1-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.0 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0 0.3 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.0 0.3 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 0.0 REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION Genes involved in activated TAK1 mediates p38 MAPK activation
0.0 0.2 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 0.2 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
0.0 0.3 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.0 0.4 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.0 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.0 0.3 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 0.2 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 0.2 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 0.1 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.2 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 0.2 REACTOME BOTULINUM NEUROTOXICITY Genes involved in Botulinum neurotoxicity
0.0 0.6 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.1 REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.0 0.0 REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.0 0.1 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 0.1 REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.0 0.1 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.0 0.1 REACTOME P38MAPK EVENTS Genes involved in p38MAPK events