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ENCODE: H3K4me1 ChIP-Seq of primary human cells

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Results for SMAD3

Z-value: 1.73

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Transcription factors associated with SMAD3

Gene Symbol	Gene ID	Gene Info
SMAD3 Ensembl NCBI GeneCards UniProt	ENSG00000166949.11	SMAD family member 3

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
chr15_67224686_67224837	SMAD3	131340	0.050101	0.95	8.6e-05	Click!
chr15_67458204_67458355	SMAD3	78	0.977739	0.95	1.1e-04	Click!
chr15_67458623_67458774	SMAD3	171	0.960628	0.94	1.4e-04	Click!
chr15_67492392_67492556	SMAD3	15361	0.202510	0.94	1.9e-04	Click!
chr15_67417692_67417846	SMAD3	285	0.930307	0.93	2.3e-04	Click!

Activity of the SMAD3 motif across conditions

Conditions sorted by the z-value of the SMAD3 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr19_55998538_55999092	0.97	SSC5D	scavenger receptor cysteine rich domain containing (5 domains)	956	0.27
chr11_65257627_65258285	0.89	SCYL1	SCY1-like 1 (S. cerevisiae)	34592	0.08
chr11_72020089_72020240	0.84	CLPB	ClpB caseinolytic peptidase B homolog (E. coli)	536	0.69
chr1_234755566_234755985	0.78	IRF2BP2	interferon regulatory factor 2 binding protein 2	10504	0.19
chr7_134574979_134575413	0.69	CALD1	caldesmon 1	955	0.69
chr1_116039442_116039593	0.68	ENSG00000265534	.	11245	0.27
chr17_76370784_76371498	0.67	PGS1	phosphatidylglycerophosphate synthase 1	3580	0.16
chr7_80352686_80352837	0.67	CD36	CD36 molecule (thrombospondin receptor)	50069	0.19
chr9_130284478_130284823	0.66	FAM129B	family with sequence similarity 129, member B	46717	0.09
chr16_57798443_57798674	0.65	KIFC3	kinesin family member C3	257	0.89
chr8_23213962_23214375	0.65	LOXL2	lysyl oxidase-like 2	14471	0.16
chr5_52718812_52718963	0.64	FST	follistatin	57352	0.16
chr18_55873061_55873212	0.62	RP11-718I15.1		10208	0.22
chr1_68190930_68191081	0.60	GADD45A	growth arrest and DNA-damage-inducible, alpha	40121	0.15
chr10_111655218_111655499	0.60	XPNPEP1	X-prolyl aminopeptidase (aminopeptidase P) 1, soluble	12219	0.21
chr17_75118947_75119098	0.60	SEC14L1	SEC14-like 1 (S. cerevisiae)	4933	0.22
chr5_102785874_102786025	0.59	NUDT12	nudix (nucleoside diphosphate linked moiety X)-type motif 12	112541	0.07
chr7_157102085_157102478	0.59	ENSG00000266453	.	3794	0.28
chr10_79152930_79153197	0.59	KCNMA1	potassium large conductance calcium-activated channel, subfamily M, alpha member 1	10679	0.24
chr1_120174414_120175022	0.59	ZNF697	zinc finger protein 697	15678	0.18
chr1_56046295_56046737	0.58	ENSG00000272051	.	95871	0.09
chr3_55195992_55196143	0.57	LRTM1	leucine-rich repeats and transmembrane domains 1	194952	0.03
chr6_119469482_119469711	0.57	FAM184A	family with sequence similarity 184, member A	756	0.75
chr4_5755349_5755500	0.56	EVC	Ellis van Creveld syndrome	42482	0.16
chr1_201717737_201718015	0.55	NAV1	neuron navigator 1	8880	0.13
chr17_27045400_27045747	0.54	RAB34	RAB34, member RAS oncogene family	126	0.8
chr9_695641_695792	0.54	RP11-130C19.3		10161	0.22
chr13_91068237_91068388	0.54	ENSG00000207858	.	184876	0.03
chr14_76289096_76289247	0.54	RP11-270M14.4		14383	0.24
chr6_18043310_18043548	0.54	KIF13A	kinesin family member 13A	55575	0.13
chr1_17275864_17276015	0.54	CROCC	ciliary rootlet coiled-coil, rootletin	26689	0.11
chr10_51060106_51060257	0.53	PARG	poly (ADP-ribose) glycohydrolase	70534	0.1
chr7_18809339_18809490	0.53	ENSG00000222164	.	38488	0.21
chr22_45949176_45949470	0.52	FBLN1	fibulin 1	34660	0.15
chr14_55914091_55914242	0.52	TBPL2	TATA box binding protein like 2	6832	0.24
chr6_40925892_40926043	0.52	UNC5CL	unc-5 homolog C (C. elegans)-like	76907	0.08
chr5_87437759_87438959	0.52	TMEM161B	transmembrane protein 161B	78089	0.11
chr14_69421781_69422763	0.52	ACTN1	actinin, alpha 1	8007	0.23
chr3_45686706_45687144	0.51	LIMD1-AS1	LIMD1 antisense RNA 1	43449	0.12
chr7_46020334_46020485	0.51	ENSG00000239004	.	5372	0.27
chr1_66932158_66932309	0.51	SGIP1	SH3-domain GRB2-like (endophilin) interacting protein 1	66833	0.12
chr20_43182087_43182266	0.51	PKIG	protein kinase (cAMP-dependent, catalytic) inhibitor gamma	21606	0.13
chr8_106728883_106729056	0.51	RP11-642D21.2		30976	0.2
chr2_45901435_45901586	0.51	U51244.2		1105	0.57
chr14_69472810_69472961	0.50	ACTN1-AS1	ACTN1 antisense RNA 1	26127	0.19
chr13_114630352_114630503	0.50	GAS6	growth arrest-specific 6	63381	0.13
chr8_128265644_128265795	0.50	POU5F1B	POU class 5 homeobox 1B	160816	0.04
chr4_129260645_129260796	0.50	PGRMC2	progesterone receptor membrane component 2	50736	0.19
chr17_1987997_1988266	0.50	RP11-667K14.5		4844	0.12
chr2_218714298_218714449	0.50	TNS1	tensin 1	7490	0.27
chr17_78933014_78933165	0.50	CTD-2561B21.3		2424	0.18
chr9_107826117_107826807	0.50	ENSG00000201583	.	32575	0.22
chr7_79775488_79775920	0.50	GNAI1	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	10633	0.29
chr3_99384870_99385021	0.49	ENSG00000263810	.	25470	0.21
chr4_120130830_120131163	0.49	RP11-455G16.1	Uncharacterized protein	2671	0.26
chr22_46392610_46393183	0.49	WNT7B	wingless-type MMTV integration site family, member 7B	19887	0.12
chr17_48105880_48106284	0.49	ITGA3	integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)	27257	0.11
chr20_43964414_43964565	0.49	SDC4	syndecan 4	12575	0.11
chr3_123536812_123536963	0.49	ENSG00000207002	.	3963	0.26
chr22_37892945_37893096	0.49	CARD10	caspase recruitment domain family, member 10	7067	0.14
chr15_74689731_74690089	0.49	CYP11A1	cytochrome P450, family 11, subfamily A, polypeptide 1	29829	0.11
chr21_39221535_39221777	0.49	KCNJ6	potassium inwardly-rectifying channel, subfamily J, member 6	63901	0.13
chr10_11799148_11799299	0.48	ECHDC3	enoyl CoA hydratase domain containing 3	9949	0.25
chr14_73190563_73190714	0.48	ENSG00000206751	.	129401	0.05
chr2_55382682_55382833	0.48	RTN4	reticulon 4	43000	0.11
chr2_75119840_75119991	0.48	HK2	hexokinase 2	57618	0.12
chr6_114421482_114421633	0.48	RP3-399L15.3		11993	0.23
chr7_27718120_27718271	0.48	HIBADH	3-hydroxyisobutyrate dehydrogenase	15581	0.23
chr3_111488513_111488664	0.48	PHLDB2	pleckstrin homology-like domain, family B, member 2	37244	0.18
chr2_227623514_227623665	0.48	IRS1	insulin receptor substrate 1	40886	0.16
chr1_8078544_8078695	0.48	ERRFI1	ERBB receptor feedback inhibitor 1	2926	0.27
chr1_85786366_85786652	0.48	ENSG00000264380	.	36216	0.12
chr11_76464159_76464310	0.48	RP11-21L23.4		15033	0.14
chr16_31075775_31076376	0.47	ZNF668	zinc finger protein 668	215	0.75
chr5_149697150_149697301	0.47	ARSI	arylsulfatase family, member I	14709	0.17
chr2_149514080_149514280	0.47	EPC2	enhancer of polycomb homolog 2 (Drosophila)	66397	0.11
chr21_28942271_28942554	0.47	ADAMTS5	ADAM metallopeptidase with thrombospondin type 1 motif, 5	603580	0.0
chr3_172466504_172466655	0.47	ECT2	epithelial cell transforming sequence 2 oncogene	1893	0.3
chr9_114721568_114721719	0.46	ENSG00000266315	.	27263	0.16
chr17_597333_597484	0.46	VPS53	vacuolar protein sorting 53 homolog (S. cerevisiae)	20541	0.16
chr11_120176796_120176947	0.46	POU2F3	POU class 2 homeobox 3	518	0.77
chr17_17642775_17643230	0.46	RAI1-AS1	RAI1 antisense RNA 1	31133	0.12
chr5_16539153_16539304	0.46	FAM134B	family with sequence similarity 134, member B	30121	0.18
chr2_47313810_47313961	0.45	AC073283.7		18924	0.18
chr15_93572424_93572985	0.45	CHD2	chromodomain helicase DNA binding protein 2	20608	0.22
chr14_25591538_25591689	0.45	STXBP6	syntaxin binding protein 6 (amisyn)	72110	0.13
chr12_88704360_88704511	0.45	ENSG00000199245	.	119784	0.06
chr17_73689039_73689190	0.45	SAP30BP	SAP30 binding protein	488	0.65
chr3_52124413_52124839	0.45	LINC00696	long intergenic non-protein coding RNA 696	27059	0.11
chr10_80911217_80911486	0.45	ZMIZ1	zinc finger, MIZ-type containing 1	82559	0.1
chr14_51835224_51835375	0.45	ENSG00000201820	.	114558	0.05
chr13_52920227_52920378	0.45	TPTE2P2	transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 pseudogene 2	48339	0.12
chr15_84517699_84517850	0.45	ENSG00000200444	.	24069	0.23
chr2_33467839_33468340	0.45	LTBP1	latent transforming growth factor beta binding protein 1	640	0.79
chr11_92029038_92029189	0.44	FAT3	FAT atypical cadherin 3	56149	0.17
chr7_55131985_55132136	0.44	EGFR	epidermal growth factor receptor	45249	0.19
chr1_78005323_78005533	0.44	AK5	adenylate kinase 5	7636	0.25
chr22_36863560_36864238	0.44	TXN2	thioredoxin 2	13488	0.14
chr5_14154020_14154339	0.44	TRIO	trio Rho guanine nucleotide exchange factor	10350	0.32
chr18_56665589_56665740	0.44	ENSG00000251870	.	72136	0.1
chr8_30278565_30278948	0.44	RBPMS	RNA binding protein with multiple splicing	21377	0.21
chr21_37222664_37222964	0.44	FKSG68		47913	0.16
chr13_52945814_52946215	0.44	ENSG00000199605	.	28125	0.16
chr3_124512536_124512716	0.44	ITGB5-AS1	ITGB5 antisense RNA 1	12624	0.17
chr10_94725570_94725721	0.44	EXOC6	exocyst complex component 6	31586	0.2
chr17_76677483_76677634	0.44	ENSG00000252391	.	15321	0.19
chr5_57751450_57751723	0.44	PLK2	polo-like kinase 2	4501	0.26
chr12_46796862_46797190	0.43	SLC38A2	solute carrier family 38, member 2	30376	0.2
chr14_73267837_73267988	0.43	ENSG00000206751	.	52127	0.14
chr2_43152776_43153425	0.43	HAAO	3-hydroxyanthranilate 3,4-dioxygenase	133368	0.05
chr15_74710605_74710756	0.43	SEMA7A	semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)	15321	0.14
chr10_126725690_126725841	0.43	ENSG00000264572	.	4326	0.24
chr2_19807324_19807591	0.43	OSR1	odd-skipped related transciption factor 1	249043	0.02
chr2_182654523_182654674	0.43	ENSG00000221023	.	51265	0.14
chr11_64427589_64427881	0.43	AP001092.4		13864	0.15
chr2_111206449_111206764	0.43	RP13-1039J1.3		213	0.94
chr6_17928540_17928933	0.43	KIF13A	kinesin family member 13A	58958	0.14
chr17_63014430_63015230	0.42	RP11-583F2.5		33197	0.12
chr2_190258502_190258653	0.42	WDR75	WD repeat domain 75	47582	0.16
chr6_45621464_45621615	0.42	ENSG00000252738	.	7698	0.32
chr15_57129370_57129631	0.42	ZNF280D	zinc finger protein 280D	81269	0.1
chr8_128919473_128919624	0.42	TMEM75	transmembrane protein 75	41043	0.15
chr17_79532915_79533078	0.42	NPLOC4	nuclear protein localization 4 homolog (S. cerevisiae)	632	0.54
chr4_170038662_170038813	0.42	RP11-327O17.2		84208	0.08
chr10_105398515_105398780	0.42	SH3PXD2A	SH3 and PX domains 2A	22815	0.14
chr5_64358925_64359076	0.41	ENSG00000207439	.	60196	0.16
chr3_81776683_81776834	0.41	GBE1	glucan (1,4-alpha-), branching enzyme 1	16022	0.31
chr8_53529590_53529741	0.41	RB1CC1	RB1-inducible coiled-coil 1	18929	0.24
chr3_115059944_115060095	0.41	ZBTB20	zinc finger and BTB domain containing 20	193901	0.03
chr12_58818734_58818885	0.41	RP11-362K2.2	Protein LOC100506869	119098	0.06
chr1_154703230_154703438	0.41	ADAR	adenosine deaminase, RNA-specific	102860	0.05
chr2_69453257_69453408	0.41	ENSG00000199460	.	43323	0.14
chr5_136554415_136554566	0.41	SPOCK1	sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1	94737	0.09
chr15_63031651_63031802	0.41	TLN2	talin 2	12437	0.2
chr3_52039773_52040512	0.41	RPL29	ribosomal protein L29	10184	0.09
chr17_45787218_45787648	0.41	TBKBP1	TBK1 binding protein 1	14803	0.13
chr6_105876584_105876735	0.41	PREP	prolyl endopeptidase	25700	0.25
chr12_13054850_13055147	0.41	GPRC5A	G protein-coupled receptor, family C, group 5, member A	7005	0.15
chr18_65266738_65266889	0.41	DSEL	dermatan sulfate epimerase-like	82596	0.11
chr15_67419351_67419566	0.41	SMAD3	SMAD family member 3	983	0.62
chr15_75986048_75986554	0.41	AC105020.1	Uncharacterized protein; cDNA FLJ12988 fis, clone NT2RP3000080	15629	0.09
chr7_64905809_64905960	0.41	ZNF92	zinc finger protein 92	67090	0.11
chr15_48665560_48665810	0.40	DUT	deoxyuridine triphosphatase	41082	0.14
chr3_194918550_194918921	0.40	XXYLT1	xyloside xylosyltransferase 1	13208	0.16
chr1_201500197_201500348	0.40	CSRP1	cysteine and glycine-rich protein 1	21688	0.15
chr9_133655761_133655912	0.40	ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	54617	0.13
chr17_25711228_25711379	0.40	TBC1D3P5	TBC1 domain family, member 3 pseudogene 5	35261	0.17
chr1_61918584_61919140	0.40	NFIA	nuclear factor I/A	46518	0.19
chr2_33294167_33294318	0.40	LTBP1	latent transforming growth factor beta binding protein 1	65231	0.12
chr1_86617171_86617322	0.40	COL24A1	collagen, type XXIV, alpha 1	4875	0.34
chr6_43977935_43978086	0.40	ENSG00000265518	.	2728	0.23
chr5_136147505_136147656	0.40	ENSG00000222285	.	157415	0.04
chr1_846289_846488	0.40	SAMD11	sterile alpha motif domain containing 11	13872	0.11
chr6_16985892_16986043	0.40	STMND1	stathmin domain containing 1	116522	0.07
chr20_46558387_46558538	0.40	ENSG00000238785	.	25370	0.21
chr7_73236720_73236871	0.40	CLDN4	claudin 4	5279	0.16
chr12_13347125_13347538	0.40	EMP1	epithelial membrane protein 1	2319	0.38
chr9_89894332_89894483	0.40	ENSG00000212421	.	19042	0.28
chr13_30497661_30497812	0.40	LINC00572	long intergenic non-protein coding RNA 572	3052	0.37
chr7_1164562_1164713	0.40	C7orf50	chromosome 7 open reading frame 50	13239	0.12
chr2_15310901_15311052	0.40	NBAS	neuroblastoma amplified sequence	19545	0.3
chr9_111240432_111240727	0.40	ENSG00000222512	.	119370	0.06
chr3_11243097_11243459	0.40	HRH1	histamine receptor H1	24439	0.24
chr14_71709023_71709174	0.40	AC004817.1	HCG2028611; Uncharacterized protein	25636	0.21
chr17_49031674_49031909	0.39	SPAG9	sperm associated antigen 9	39507	0.14
chr8_118960890_118961041	0.39	EXT1	exostosin glycosyltransferase 1	161688	0.04
chr3_188067044_188067254	0.39	LPP	LIM domain containing preferred translocation partner in lipoma	109497	0.07
chr1_234858071_234858911	0.39	IRF2BP2	interferon regulatory factor 2 binding protein 2	113220	0.06
chr13_40638535_40638849	0.39	ENSG00000207458	.	162272	0.04
chr21_40392911_40393288	0.39	ENSG00000272015	.	126390	0.05
chr10_72123522_72123673	0.39	LRRC20	leucine rich repeat containing 20	17817	0.18
chr1_44794530_44794681	0.39	ENSG00000252146	.	4245	0.2
chr13_43733384_43733535	0.39	DNAJC15	DnaJ (Hsp40) homolog, subfamily C, member 15	136120	0.05
chr11_130348758_130348944	0.39	ADAMTS15	ADAM metallopeptidase with thrombospondin type 1 motif, 15	29982	0.21
chr8_30322063_30322214	0.39	RBPMS	RNA binding protein with multiple splicing	22005	0.23
chr6_150208883_150209034	0.39	RAET1E-AS1	RAET1E antisense RNA 1	2281	0.18
chr3_57935477_57935765	0.39	SLMAP	sarcolemma associated protein	32929	0.19
chr17_18122099_18122385	0.39	LLGL1	lethal giant larvae homolog 1 (Drosophila)	6659	0.12
chr15_101498493_101498644	0.39	LRRK1	leucine-rich repeat kinase 1	39018	0.15
chr5_135329366_135329517	0.39	TGFBI	transforming growth factor, beta-induced, 68kDa	35143	0.15
chr1_16124336_16124487	0.39	FBLIM1	filamin binding LIM protein 1	32963	0.1
chr7_40337996_40338297	0.39	SUGCT	succinylCoA:glutarate-CoA transferase	163527	0.04
chr12_71054642_71054987	0.39	PTPRB	protein tyrosine phosphatase, receptor type, B	23594	0.24
chr7_152050844_152051077	0.39	ENSG00000253088	.	48905	0.15
chr3_141080488_141080639	0.38	RP11-438D8.2		5416	0.25
chr10_101804735_101804886	0.38	CPN1	carboxypeptidase N, polypeptide 1	20341	0.16
chr2_18766689_18766840	0.38	NT5C1B	5'-nucleotidase, cytosolic IB	1587	0.31
chr18_20047269_20047420	0.38	CTAGE1	cutaneous T-cell lymphoma-associated antigen 1	49466	0.17
chr11_12840572_12840723	0.38	RP11-47J17.3		4567	0.24
chr2_181848570_181849184	0.38	UBE2E3	ubiquitin-conjugating enzyme E2E 3	2127	0.37
chr5_136806058_136806209	0.38	SPOCK1	sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1	28114	0.22
chr2_238209455_238209606	0.38	AC112715.2	Uncharacterized protein	43796	0.17
chr17_46080195_46080690	0.38	RP11-6N17.10		6880	0.1
chr19_18788699_18789106	0.38	CRTC1	CREB regulated transcription coactivator 1	5585	0.15
chr7_151297671_151297822	0.38	PRKAG2	protein kinase, AMP-activated, gamma 2 non-catalytic subunit	31693	0.18
chr9_111870490_111871218	0.38	TMEM245	transmembrane protein 245	11371	0.19
chr7_69849817_69849968	0.38	AUTS2	autism susceptibility candidate 2	344233	0.01
chr2_121722334_121722485	0.38	ENSG00000221321	.	70240	0.12
chr13_98862550_98862701	0.38	ENSG00000263399	.	1847	0.29
chr6_17865598_17865749	0.38	KIF13A	kinesin family member 13A	48242	0.16

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of SMAD3

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.6	GO:0051832	evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.2	0.6	GO:0071694	sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.2	0.6	GO:0032431	activation of phospholipase A2 activity(GO:0032431)
0.1	0.4	GO:0060426	lung vasculature development(GO:0060426)
0.1	0.8	GO:0045217	cell junction maintenance(GO:0034331) cell-cell junction maintenance(GO:0045217)
0.1	0.9	GO:0061081	positive regulation of myeloid leukocyte cytokine production involved in immune response(GO:0061081)
0.1	0.7	GO:0007171	activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.1	0.3	GO:0060083	smooth muscle contraction involved in micturition(GO:0060083)
0.1	0.3	GO:0042118	endothelial cell activation(GO:0042118)
0.1	0.5	GO:0061525	hindgut morphogenesis(GO:0007442) hindgut development(GO:0061525)
0.1	0.3	GO:0010766	negative regulation of sodium ion transport(GO:0010766)
0.1	0.1	GO:0048845	venous blood vessel morphogenesis(GO:0048845)
0.1	0.3	GO:0031946	regulation of glucocorticoid biosynthetic process(GO:0031946)
0.1	0.6	GO:0007185	transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.1	0.6	GO:0035414	negative regulation of catenin import into nucleus(GO:0035414)
0.1	0.3	GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.1	0.2	GO:0051898	negative regulation of protein kinase B signaling(GO:0051898)
0.1	0.2	GO:0046813	receptor-mediated virion attachment to host cell(GO:0046813)
0.1	0.2	GO:0010842	retina layer formation(GO:0010842)
0.1	0.4	GO:0030321	transepithelial chloride transport(GO:0030321)
0.1	0.2	GO:0035385	Roundabout signaling pathway(GO:0035385)
0.1	0.2	GO:0070295	renal water absorption(GO:0070295)
0.1	0.3	GO:0072383	plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.1	0.2	GO:0060014	granulosa cell differentiation(GO:0060014)
0.1	0.4	GO:0032277	negative regulation of gonadotropin secretion(GO:0032277)
0.1	0.2	GO:0060433	bronchus development(GO:0060433)
0.1	0.3	GO:0008218	bioluminescence(GO:0008218)
0.1	0.3	GO:0060013	righting reflex(GO:0060013)
0.1	0.4	GO:0043922	negative regulation by host of viral transcription(GO:0043922)
0.1	0.3	GO:0048702	embryonic neurocranium morphogenesis(GO:0048702)
0.1	0.3	GO:0009188	ADP biosynthetic process(GO:0006172) purine nucleoside diphosphate biosynthetic process(GO:0009136) purine ribonucleoside diphosphate biosynthetic process(GO:0009180) ribonucleoside diphosphate biosynthetic process(GO:0009188)
0.1	0.2	GO:0045332	lipid translocation(GO:0034204) phospholipid translocation(GO:0045332)
0.1	0.4	GO:0060638	mesenchymal-epithelial cell signaling(GO:0060638)
0.1	0.3	GO:0045747	positive regulation of Notch signaling pathway(GO:0045747)
0.1	0.2	GO:0001996	positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996)
0.1	0.4	GO:0033137	negative regulation of peptidyl-serine phosphorylation(GO:0033137)
0.1	0.3	GO:0060707	trophoblast giant cell differentiation(GO:0060707)
0.1	0.1	GO:0061213	positive regulation of mesonephros development(GO:0061213) positive regulation of branching involved in ureteric bud morphogenesis(GO:0090190)
0.1	0.7	GO:0031581	hemidesmosome assembly(GO:0031581)
0.1	0.2	GO:0051124	synaptic growth at neuromuscular junction(GO:0051124)
0.1	0.3	GO:0060438	trachea development(GO:0060438)
0.1	0.1	GO:0071502	cellular response to temperature stimulus(GO:0071502)
0.1	0.1	GO:0021798	forebrain dorsal/ventral pattern formation(GO:0021798)
0.1	0.2	GO:0045617	negative regulation of keratinocyte differentiation(GO:0045617)
0.1	0.1	GO:0060841	venous blood vessel development(GO:0060841)
0.1	0.6	GO:0048745	smooth muscle tissue development(GO:0048745)
0.1	0.2	GO:0007258	JUN phosphorylation(GO:0007258)
0.1	0.1	GO:0060129	thyroid-stimulating hormone-secreting cell differentiation(GO:0060129)
0.1	0.2	GO:0071277	cellular response to calcium ion(GO:0071277)
0.1	0.2	GO:0060737	prostate gland morphogenetic growth(GO:0060737)
0.1	0.2	GO:0048853	forebrain morphogenesis(GO:0048853)
0.1	0.5	GO:0009629	response to gravity(GO:0009629)
0.1	0.2	GO:0033145	positive regulation of intracellular steroid hormone receptor signaling pathway(GO:0033145)
0.1	0.2	GO:0048096	chromatin-mediated maintenance of transcription(GO:0048096)
0.1	0.2	GO:0042268	regulation of cytolysis(GO:0042268)
0.1	0.8	GO:0048286	lung alveolus development(GO:0048286)
0.1	0.2	GO:0060174	limb bud formation(GO:0060174)
0.1	0.2	GO:0032927	positive regulation of activin receptor signaling pathway(GO:0032927)
0.1	0.3	GO:0030579	ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.1	0.2	GO:0072311	renal filtration cell differentiation(GO:0061318) glomerular epithelium development(GO:0072010) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.1	0.5	GO:0007016	cytoskeletal anchoring at plasma membrane(GO:0007016)
0.1	0.5	GO:0043277	apoptotic cell clearance(GO:0043277)
0.1	0.3	GO:0048755	branching morphogenesis of a nerve(GO:0048755)
0.1	0.1	GO:0007352	zygotic specification of dorsal/ventral axis(GO:0007352)
0.1	0.3	GO:0060390	regulation of SMAD protein import into nucleus(GO:0060390)
0.1	0.2	GO:0045162	clustering of voltage-gated sodium channels(GO:0045162)
0.1	0.4	GO:0033327	Leydig cell differentiation(GO:0033327)
0.0	0.2	GO:0017085	response to insecticide(GO:0017085)
0.0	0.2	GO:0090231	regulation of spindle checkpoint(GO:0090231)
0.0	0.6	GO:0034605	cellular response to heat(GO:0034605)
0.0	0.2	GO:0006048	UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.0	0.2	GO:0018101	protein citrullination(GO:0018101)
0.0	0.2	GO:0071731	response to nitric oxide(GO:0071731)
0.0	0.1	GO:0046185	aldehyde catabolic process(GO:0046185)
0.0	0.1	GO:0001306	age-dependent response to oxidative stress(GO:0001306) age-dependent general metabolic decline(GO:0007571)
0.0	0.1	GO:0072201	negative regulation of mesenchymal cell proliferation(GO:0072201)
0.0	0.1	GO:0060900	embryonic camera-type eye formation(GO:0060900)
0.0	0.1	GO:0046628	positive regulation of insulin receptor signaling pathway(GO:0046628) positive regulation of cellular response to insulin stimulus(GO:1900078)
0.0	0.1	GO:0005981	regulation of glycogen catabolic process(GO:0005981)
0.0	0.1	GO:0048149	behavioral response to ethanol(GO:0048149)
0.0	0.0	GO:0002043	blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.0	0.0	GO:0051176	positive regulation of sulfur metabolic process(GO:0051176)
0.0	0.1	GO:1902803	regulation of synaptic vesicle transport(GO:1902803) regulation of synaptic vesicle exocytosis(GO:2000300)
0.0	0.0	GO:0045715	negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715)
0.0	0.2	GO:0046952	ketone body catabolic process(GO:0046952)
0.0	0.2	GO:0048630	skeletal muscle tissue growth(GO:0048630)
0.0	0.2	GO:0060754	mast cell chemotaxis(GO:0002551) regulation of mast cell chemotaxis(GO:0060753) positive regulation of mast cell chemotaxis(GO:0060754) mast cell migration(GO:0097531)
0.0	0.2	GO:0006564	L-serine biosynthetic process(GO:0006564)
0.0	0.3	GO:0046487	glyoxylate metabolic process(GO:0046487)
0.0	0.0	GO:0003099	positive regulation of the force of heart contraction by chemical signal(GO:0003099)
0.0	0.0	GO:0010757	negative regulation of plasminogen activation(GO:0010757)
0.0	0.1	GO:0022605	oogenesis stage(GO:0022605)
0.0	0.1	GO:0045906	negative regulation of vasoconstriction(GO:0045906)
0.0	0.1	GO:2000095	regulation of non-canonical Wnt signaling pathway(GO:2000050) regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000095)
0.0	0.0	GO:0060592	mammary gland formation(GO:0060592) mammary placode formation(GO:0060596)
0.0	0.2	GO:0015889	cobalamin transport(GO:0015889)
0.0	0.2	GO:0060347	heart trabecula formation(GO:0060347) heart trabecula morphogenesis(GO:0061384)
0.0	0.1	GO:0007132	meiotic metaphase I(GO:0007132)
0.0	0.1	GO:0030505	inorganic diphosphate transport(GO:0030505)
0.0	0.2	GO:0022027	interkinetic nuclear migration(GO:0022027)
0.0	0.1	GO:0003091	renal water homeostasis(GO:0003091)
0.0	0.3	GO:0006108	malate metabolic process(GO:0006108)
0.0	0.1	GO:0001973	adenosine receptor signaling pathway(GO:0001973) G-protein coupled purinergic receptor signaling pathway(GO:0035588)
0.0	0.1	GO:0051409	response to nitrosative stress(GO:0051409)
0.0	0.1	GO:0055089	fatty acid homeostasis(GO:0055089)
0.0	0.1	GO:0071072	negative regulation of phospholipid biosynthetic process(GO:0071072)
0.0	0.4	GO:0036294	cellular response to decreased oxygen levels(GO:0036294) cellular response to oxygen levels(GO:0071453) cellular response to hypoxia(GO:0071456)
0.0	0.1	GO:0014819	regulation of skeletal muscle contraction(GO:0014819)
0.0	0.1	GO:0048570	notochord morphogenesis(GO:0048570)
0.0	0.1	GO:0043589	skin morphogenesis(GO:0043589)
0.0	0.0	GO:1902305	regulation of sodium:proton antiporter activity(GO:0032415) regulation of sodium ion transmembrane transport(GO:1902305) regulation of sodium ion transmembrane transporter activity(GO:2000649)
0.0	0.1	GO:0009414	response to water deprivation(GO:0009414) response to water(GO:0009415)
0.0	0.1	GO:0043268	positive regulation of potassium ion transport(GO:0043268)
0.0	0.1	GO:0070634	transepithelial ammonium transport(GO:0070634)
0.0	0.1	GO:0072268	pattern specification involved in metanephros development(GO:0072268)
0.0	0.2	GO:0044319	wound healing, spreading of epidermal cells(GO:0035313) wound healing, spreading of cells(GO:0044319) epiboly(GO:0090504) epiboly involved in wound healing(GO:0090505)
0.0	0.1	GO:0090162	establishment of epithelial cell polarity(GO:0090162)
0.0	0.2	GO:0060155	platelet dense granule organization(GO:0060155)
0.0	0.1	GO:0014912	negative regulation of smooth muscle cell migration(GO:0014912)
0.0	0.1	GO:0034501	protein localization to kinetochore(GO:0034501)
0.0	0.2	GO:0051382	kinetochore assembly(GO:0051382)
0.0	0.1	GO:0019367	fatty acid elongation, saturated fatty acid(GO:0019367)
0.0	0.1	GO:0048875	surfactant homeostasis(GO:0043129) chemical homeostasis within a tissue(GO:0048875)
0.0	0.1	GO:0060687	regulation of branching involved in prostate gland morphogenesis(GO:0060687)
0.0	0.0	GO:0010989	negative regulation of low-density lipoprotein particle clearance(GO:0010989)
0.0	0.1	GO:0006562	proline catabolic process(GO:0006562)
0.0	0.1	GO:0060236	regulation of mitotic spindle organization(GO:0060236)
0.0	0.1	GO:0035426	extracellular matrix-cell signaling(GO:0035426)
0.0	0.0	GO:0014832	urinary bladder smooth muscle contraction(GO:0014832) urinary tract smooth muscle contraction(GO:0014848)
0.0	0.1	GO:1903332	regulation of protein folding(GO:1903332)
0.0	0.4	GO:0035329	hippo signaling(GO:0035329)
0.0	0.1	GO:0031282	regulation of guanylate cyclase activity(GO:0031282)
0.0	0.1	GO:0001660	fever generation(GO:0001660)
0.0	0.1	GO:0018206	peptidyl-methionine modification(GO:0018206)
0.0	0.1	GO:0048245	eosinophil chemotaxis(GO:0048245) eosinophil migration(GO:0072677)
0.0	0.1	GO:0006290	pyrimidine dimer repair(GO:0006290)
0.0	0.1	GO:0010891	negative regulation of sequestering of triglyceride(GO:0010891)
0.0	0.0	GO:0043117	positive regulation of vascular permeability(GO:0043117)
0.0	0.1	GO:0007191	adenylate cyclase-activating dopamine receptor signaling pathway(GO:0007191)
0.0	0.1	GO:0018242	protein O-linked glycosylation via serine(GO:0018242) protein O-linked glycosylation via threonine(GO:0018243)
0.0	0.1	GO:0050916	sensory perception of sweet taste(GO:0050916)
0.0	0.1	GO:0006434	seryl-tRNA aminoacylation(GO:0006434)
0.0	0.1	GO:0042149	cellular response to glucose starvation(GO:0042149)
0.0	0.5	GO:0007340	acrosome reaction(GO:0007340)
0.0	0.1	GO:0061101	neuroendocrine cell differentiation(GO:0061101)
0.0	0.1	GO:0032467	positive regulation of cytokinesis(GO:0032467)
0.0	0.0	GO:2000542	negative regulation of gastrulation(GO:2000542)
0.0	0.1	GO:0090493	dopamine uptake involved in synaptic transmission(GO:0051583) catecholamine uptake involved in synaptic transmission(GO:0051934) catecholamine uptake(GO:0090493) dopamine uptake(GO:0090494)
0.0	0.2	GO:0010225	response to UV-C(GO:0010225)
0.0	0.2	GO:0006703	estrogen biosynthetic process(GO:0006703)
0.0	0.1	GO:0046855	phosphorylated carbohydrate dephosphorylation(GO:0046838) inositol phosphate dephosphorylation(GO:0046855)
0.0	0.1	GO:0051927	obsolete negative regulation of calcium ion transport via voltage-gated calcium channel activity(GO:0051927)
0.0	0.1	GO:0042640	anagen(GO:0042640)
0.0	0.1	GO:1903170	negative regulation of release of sequestered calcium ion into cytosol(GO:0051280) positive regulation of sequestering of calcium ion(GO:0051284) negative regulation of calcium ion transmembrane transport(GO:1903170)
0.0	0.1	GO:0014721	voluntary skeletal muscle contraction(GO:0003010) twitch skeletal muscle contraction(GO:0014721)
0.0	0.1	GO:0050919	negative chemotaxis(GO:0050919)
0.0	0.1	GO:0090047	obsolete positive regulation of transcription regulator activity(GO:0090047)
0.0	0.1	GO:0050655	dermatan sulfate proteoglycan metabolic process(GO:0050655)
0.0	0.4	GO:0045104	intermediate filament cytoskeleton organization(GO:0045104)
0.0	0.1	GO:0008612	peptidyl-lysine modification to peptidyl-hypusine(GO:0008612)
0.0	0.1	GO:0007028	cytoplasm organization(GO:0007028)
0.0	0.1	GO:0071800	podosome assembly(GO:0071800)
0.0	0.1	GO:0030011	maintenance of cell polarity(GO:0030011)
0.0	0.1	GO:0007090	obsolete regulation of S phase of mitotic cell cycle(GO:0007090)
0.0	0.0	GO:0072131	kidney mesenchyme morphogenesis(GO:0072131) metanephric mesenchyme morphogenesis(GO:0072133)
0.0	0.1	GO:0006686	sphingomyelin biosynthetic process(GO:0006686)
0.0	0.2	GO:1902624	positive regulation of neutrophil chemotaxis(GO:0090023) positive regulation of neutrophil migration(GO:1902624)
0.0	0.1	GO:0035511	oxidative DNA demethylation(GO:0035511)
0.0	0.1	GO:0046826	negative regulation of protein export from nucleus(GO:0046826)
0.0	0.1	GO:0007341	penetration of zona pellucida(GO:0007341)
0.0	0.1	GO:0044320	cellular response to leptin stimulus(GO:0044320) response to leptin(GO:0044321)
0.0	0.0	GO:0046349	amino sugar biosynthetic process(GO:0046349)
0.0	0.2	GO:0007520	myoblast fusion(GO:0007520)
0.0	0.3	GO:0036075	endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.0	0.1	GO:0008614	pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 metabolic process(GO:0042816) vitamin B6 biosynthetic process(GO:0042819)
0.0	0.0	GO:0045989	positive regulation of striated muscle contraction(GO:0045989)
0.0	0.1	GO:0006222	UMP biosynthetic process(GO:0006222) pyrimidine ribonucleoside monophosphate metabolic process(GO:0009173) pyrimidine ribonucleoside monophosphate biosynthetic process(GO:0009174) UMP metabolic process(GO:0046049)
0.0	0.2	GO:0008655	pyrimidine-containing compound salvage(GO:0008655) pyrimidine nucleoside salvage(GO:0043097)
0.0	0.2	GO:0060259	regulation of feeding behavior(GO:0060259)
0.0	0.0	GO:0047484	regulation of response to osmotic stress(GO:0047484)
0.0	0.1	GO:0033483	gas homeostasis(GO:0033483)
0.0	0.1	GO:0008634	obsolete negative regulation of survival gene product expression(GO:0008634)
0.0	0.1	GO:0016115	diterpenoid catabolic process(GO:0016103) terpenoid catabolic process(GO:0016115) retinoic acid catabolic process(GO:0034653)
0.0	0.0	GO:0007221	positive regulation of transcription of Notch receptor target(GO:0007221)
0.0	0.2	GO:0032459	regulation of protein oligomerization(GO:0032459)
0.0	0.1	GO:0031297	replication fork processing(GO:0031297)
0.0	0.6	GO:0070374	positive regulation of ERK1 and ERK2 cascade(GO:0070374)
0.0	0.0	GO:0021542	dentate gyrus development(GO:0021542)
0.0	0.1	GO:1903393	positive regulation of focal adhesion assembly(GO:0051894) positive regulation of cell junction assembly(GO:1901890) positive regulation of adherens junction organization(GO:1903393)
0.0	0.0	GO:0051541	elastin metabolic process(GO:0051541)
0.0	0.1	GO:0032288	myelin assembly(GO:0032288)
0.0	0.2	GO:0050872	white fat cell differentiation(GO:0050872)
0.0	0.0	GO:0046121	deoxyribonucleoside catabolic process(GO:0046121)
0.0	0.6	GO:0036503	ER-associated ubiquitin-dependent protein catabolic process(GO:0030433) ERAD pathway(GO:0036503)
0.0	0.1	GO:0006700	C21-steroid hormone biosynthetic process(GO:0006700)
0.0	0.1	GO:0033173	calcineurin-NFAT signaling cascade(GO:0033173)
0.0	0.1	GO:0033962	cytoplasmic mRNA processing body assembly(GO:0033962)
0.0	0.1	GO:0048625	myoblast fate commitment(GO:0048625)
0.0	0.4	GO:0045806	negative regulation of endocytosis(GO:0045806)
0.0	0.0	GO:0080111	DNA demethylation(GO:0080111)
0.0	0.0	GO:0061440	renal system vasculature development(GO:0061437) kidney vasculature development(GO:0061440) glomerulus vasculature development(GO:0072012) glomerular mesangium development(GO:0072109)
0.0	0.1	GO:1903301	regulation of glucokinase activity(GO:0033131) positive regulation of glucokinase activity(GO:0033133) regulation of hexokinase activity(GO:1903299) positive regulation of hexokinase activity(GO:1903301)
0.0	0.2	GO:0045880	positive regulation of smoothened signaling pathway(GO:0045880)
0.0	0.1	GO:0001778	plasma membrane repair(GO:0001778)
0.0	0.1	GO:0006449	regulation of translational termination(GO:0006449)
0.0	0.1	GO:0035335	peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0	0.1	GO:0019673	GDP-mannose metabolic process(GO:0019673)
0.0	0.2	GO:0017158	regulation of calcium ion-dependent exocytosis(GO:0017158)
0.0	0.2	GO:0009267	cellular response to starvation(GO:0009267)
0.0	0.0	GO:0060061	Spemann organizer formation(GO:0060061)
0.0	0.2	GO:0046685	response to arsenic-containing substance(GO:0046685)
0.0	0.1	GO:0032988	ribonucleoprotein complex disassembly(GO:0032988)
0.0	0.1	GO:0097035	regulation of membrane lipid distribution(GO:0097035)
0.0	0.1	GO:0006448	regulation of translational elongation(GO:0006448)
0.0	0.1	GO:0060539	diaphragm development(GO:0060539)
0.0	0.1	GO:0001866	NK T cell proliferation(GO:0001866)
0.0	0.0	GO:0015870	acetylcholine transport(GO:0015870) acetate ester transport(GO:1901374)
0.0	0.1	GO:0070306	lens fiber cell differentiation(GO:0070306)
0.0	0.1	GO:0033631	cell-cell adhesion mediated by integrin(GO:0033631)
0.0	0.2	GO:0046718	viral entry into host cell(GO:0046718)
0.0	0.1	GO:0045662	negative regulation of myoblast differentiation(GO:0045662)
0.0	0.1	GO:0043206	extracellular fibril organization(GO:0043206) fibril organization(GO:0097435)
0.0	0.1	GO:0040037	negative regulation of fibroblast growth factor receptor signaling pathway(GO:0040037)
0.0	0.0	GO:0007262	STAT protein import into nucleus(GO:0007262)
0.0	0.1	GO:0016559	peroxisome fission(GO:0016559)
0.0	0.2	GO:0015074	DNA integration(GO:0015074)
0.0	0.1	GO:0035608	protein deglutamylation(GO:0035608)
0.0	0.1	GO:0006432	phenylalanyl-tRNA aminoacylation(GO:0006432)
0.0	0.1	GO:0032786	positive regulation of DNA-templated transcription, elongation(GO:0032786)
0.0	0.1	GO:0019800	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0	0.0	GO:0060584	regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
0.0	0.1	GO:0001955	blood vessel maturation(GO:0001955)
0.0	0.1	GO:0009200	deoxyribonucleoside triphosphate metabolic process(GO:0009200)
0.0	0.1	GO:0045008	depyrimidination(GO:0045008)
0.0	0.1	GO:0043084	penile erection(GO:0043084)
0.0	0.1	GO:0006654	phosphatidic acid biosynthetic process(GO:0006654)
0.0	0.1	GO:0006167	AMP biosynthetic process(GO:0006167)
0.0	0.1	GO:0046113	nucleobase catabolic process(GO:0046113)
0.0	0.1	GO:0045046	protein import into peroxisome membrane(GO:0045046)
0.0	0.1	GO:0048617	foregut morphogenesis(GO:0007440) embryonic foregut morphogenesis(GO:0048617)
0.0	0.0	GO:0010761	fibroblast migration(GO:0010761)
0.0	0.2	GO:0009396	folic acid-containing compound biosynthetic process(GO:0009396)
0.0	0.1	GO:0071636	positive regulation of transforming growth factor beta production(GO:0071636)
0.0	0.1	GO:0001560	regulation of cell growth by extracellular stimulus(GO:0001560)
0.0	0.0	GO:0010837	regulation of keratinocyte proliferation(GO:0010837)
0.0	0.3	GO:0010458	exit from mitosis(GO:0010458)
0.0	0.0	GO:0001821	histamine secretion(GO:0001821)
0.0	0.1	GO:0046498	S-adenosylhomocysteine metabolic process(GO:0046498)
0.0	0.0	GO:0006651	diacylglycerol biosynthetic process(GO:0006651)
0.0	0.0	GO:0070050	neuron cellular homeostasis(GO:0070050)
0.0	0.1	GO:2000273	positive regulation of receptor activity(GO:2000273)
0.0	0.1	GO:0048384	retinoic acid receptor signaling pathway(GO:0048384)
0.0	0.0	GO:0048388	endosomal lumen acidification(GO:0048388)
0.0	0.1	GO:0000422	mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726)
0.0	0.0	GO:0006927	obsolete transformed cell apoptotic process(GO:0006927)
0.0	0.1	GO:0060081	membrane hyperpolarization(GO:0060081)
0.0	0.0	GO:0045835	negative regulation of meiotic nuclear division(GO:0045835)
0.0	0.1	GO:0015840	urea transport(GO:0015840)
0.0	0.0	GO:0042420	dopamine catabolic process(GO:0042420)
0.0	0.1	GO:0046476	glycosylceramide biosynthetic process(GO:0046476)
0.0	0.1	GO:0002040	sprouting angiogenesis(GO:0002040)
0.0	0.1	GO:0030573	bile acid catabolic process(GO:0030573)
0.0	0.0	GO:0050917	sensory perception of umami taste(GO:0050917)
0.0	0.0	GO:0009756	carbohydrate mediated signaling(GO:0009756)
0.0	0.0	GO:0045657	positive regulation of monocyte differentiation(GO:0045657)
0.0	0.1	GO:0010700	negative regulation of norepinephrine secretion(GO:0010700)
0.0	0.0	GO:0043173	nucleotide salvage(GO:0043173)
0.0	0.0	GO:0045077	negative regulation of interferon-gamma biosynthetic process(GO:0045077)
0.0	0.0	GO:2000757	negative regulation of histone acetylation(GO:0035067) negative regulation of protein acetylation(GO:1901984) negative regulation of peptidyl-lysine acetylation(GO:2000757)
0.0	0.0	GO:0090085	regulation of protein deubiquitination(GO:0090085)
0.0	0.1	GO:0046033	AMP metabolic process(GO:0046033)
0.0	0.0	GO:0060449	bud elongation involved in lung branching(GO:0060449)
0.0	0.1	GO:0032055	negative regulation of translation in response to stress(GO:0032055)
0.0	0.0	GO:0010159	specification of organ position(GO:0010159)
0.0	0.0	GO:0035413	positive regulation of catenin import into nucleus(GO:0035413)
0.0	0.0	GO:0003228	atrial cardiac muscle tissue development(GO:0003228) atrial cardiac muscle tissue morphogenesis(GO:0055009)
0.0	0.0	GO:0006166	purine ribonucleoside salvage(GO:0006166)
0.0	0.1	GO:0015871	choline transport(GO:0015871)
0.0	0.0	GO:0043461	proton-transporting ATP synthase complex assembly(GO:0043461) proton-transporting ATP synthase complex biogenesis(GO:0070272)
0.0	0.0	GO:0060762	regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
0.0	0.0	GO:0060992	response to fungicide(GO:0060992)
0.0	0.1	GO:0006398	mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.0	0.1	GO:0002098	tRNA wobble base modification(GO:0002097) tRNA wobble uridine modification(GO:0002098) tRNA thio-modification(GO:0034227)
0.0	0.0	GO:0031223	response to auditory stimulus(GO:0010996) auditory behavior(GO:0031223)
0.0	0.1	GO:0003156	regulation of organ formation(GO:0003156)
0.0	0.1	GO:0014075	response to amine(GO:0014075)
0.0	0.0	GO:0050955	thermoception(GO:0050955)
0.0	0.0	GO:0048170	positive regulation of long-term neuronal synaptic plasticity(GO:0048170)
0.0	0.1	GO:0030225	macrophage differentiation(GO:0030225)
0.0	0.1	GO:0016322	neuron remodeling(GO:0016322)
0.0	0.0	GO:0006659	phosphatidylserine biosynthetic process(GO:0006659)
0.0	0.1	GO:0003310	pancreatic A cell differentiation(GO:0003310)
0.0	0.1	GO:0009051	pentose-phosphate shunt, oxidative branch(GO:0009051)
0.0	0.1	GO:0019369	arachidonic acid metabolic process(GO:0019369)
0.0	0.1	GO:0035024	negative regulation of Rho protein signal transduction(GO:0035024)
0.0	0.0	GO:0071043	CUT catabolic process(GO:0071034) CUT metabolic process(GO:0071043)
0.0	0.1	GO:0009649	entrainment of circadian clock(GO:0009649)
0.0	0.0	GO:0045007	depurination(GO:0045007)
0.0	0.1	GO:0000959	mitochondrial RNA metabolic process(GO:0000959) transcription from mitochondrial promoter(GO:0006390)
0.0	0.0	GO:0010815	bradykinin catabolic process(GO:0010815)
0.0	0.3	GO:0006471	protein ADP-ribosylation(GO:0006471)
0.0	0.0	GO:0048715	negative regulation of oligodendrocyte differentiation(GO:0048715)
0.0	0.1	GO:0006591	ornithine metabolic process(GO:0006591)
0.0	0.0	GO:0045650	negative regulation of macrophage differentiation(GO:0045650)
0.0	0.2	GO:0015695	organic cation transport(GO:0015695)
0.0	0.0	GO:0032543	mitochondrial translation(GO:0032543)
0.0	0.0	GO:0007412	axon target recognition(GO:0007412)
0.0	0.0	GO:0042668	auditory receptor cell fate determination(GO:0042668)
0.0	0.1	GO:0018065	protein-cofactor linkage(GO:0018065)
0.0	0.0	GO:0031507	heterochromatin assembly(GO:0031507) heterochromatin organization(GO:0070828)
0.0	0.3	GO:0016338	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.0	0.1	GO:0048008	platelet-derived growth factor receptor signaling pathway(GO:0048008)
0.0	0.1	GO:0007567	parturition(GO:0007567)
0.0	0.1	GO:0016266	O-glycan processing(GO:0016266)
0.0	0.3	GO:0010811	positive regulation of cell-substrate adhesion(GO:0010811)
0.0	0.0	GO:0070366	regulation of hepatocyte differentiation(GO:0070366)
0.0	0.0	GO:0060037	pharyngeal system development(GO:0060037)
0.0	0.0	GO:0032509	endosome transport via multivesicular body sorting pathway(GO:0032509)
0.0	0.1	GO:0061036	positive regulation of cartilage development(GO:0061036)
0.0	0.0	GO:0034629	cellular protein complex localization(GO:0034629)
0.0	0.0	GO:0051797	regulation of hair follicle development(GO:0051797)
0.0	0.0	GO:0045627	positive regulation of T-helper 1 cell differentiation(GO:0045627)
0.0	0.0	GO:0001963	synaptic transmission, dopaminergic(GO:0001963)
0.0	0.0	GO:0006264	mitochondrial DNA replication(GO:0006264)
0.0	0.0	GO:0021555	midbrain-hindbrain boundary morphogenesis(GO:0021555)
0.0	0.0	GO:0021910	smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021910)
0.0	0.0	GO:0048251	elastic fiber assembly(GO:0048251)
0.0	0.2	GO:0030574	collagen catabolic process(GO:0030574)
0.0	0.0	GO:0001672	regulation of chromatin assembly or disassembly(GO:0001672)
0.0	0.0	GO:0048799	organ maturation(GO:0048799) bone maturation(GO:0070977)
0.0	0.1	GO:0044705	mating behavior(GO:0007617) multi-organism reproductive behavior(GO:0044705)
0.0	0.0	GO:0002023	reduction of food intake in response to dietary excess(GO:0002023)
0.0	0.0	GO:0032730	regulation of interleukin-1 alpha production(GO:0032650) positive regulation of interleukin-1 alpha production(GO:0032730)
0.0	0.0	GO:0010822	positive regulation of mitochondrion organization(GO:0010822) positive regulation of release of cytochrome c from mitochondria(GO:0090200) positive regulation of apoptotic signaling pathway(GO:2001235)
0.0	0.0	GO:0032229	negative regulation of synaptic transmission, GABAergic(GO:0032229)
0.0	0.1	GO:0034694	response to prostaglandin(GO:0034694)
0.0	0.1	GO:0035095	behavioral response to nicotine(GO:0035095)
0.0	0.1	GO:1990748	removal of superoxide radicals(GO:0019430) cellular response to oxygen radical(GO:0071450) cellular response to superoxide(GO:0071451) cellular oxidant detoxification(GO:0098869) cellular detoxification(GO:1990748)
0.0	0.0	GO:0010002	cardioblast differentiation(GO:0010002)
0.0	0.0	GO:0009235	cobalamin metabolic process(GO:0009235)
0.0	0.1	GO:0050913	sensory perception of bitter taste(GO:0050913)
0.0	0.1	GO:0050432	catecholamine secretion(GO:0050432)
0.0	0.0	GO:0009651	response to salt stress(GO:0009651)
0.0	0.2	GO:0008333	endosome to lysosome transport(GO:0008333)
0.0	0.0	GO:0017182	peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.0	0.1	GO:0050746	regulation of lipoprotein metabolic process(GO:0050746)
0.0	0.0	GO:0046835	carbohydrate phosphorylation(GO:0046835)
0.0	0.0	GO:0060840	artery morphogenesis(GO:0048844) artery development(GO:0060840)
0.0	0.1	GO:0014047	glutamate secretion(GO:0014047)
0.0	0.1	GO:0006020	inositol metabolic process(GO:0006020)
0.0	0.0	GO:0006930	substrate-dependent cell migration, cell extension(GO:0006930)
0.0	0.0	GO:0032693	negative regulation of interleukin-10 production(GO:0032693)
0.0	0.5	GO:0043062	extracellular matrix organization(GO:0030198) extracellular structure organization(GO:0043062)
0.0	0.1	GO:0018027	peptidyl-lysine dimethylation(GO:0018027)
0.0	0.2	GO:0007613	memory(GO:0007613)
0.0	0.1	GO:0007263	nitric oxide mediated signal transduction(GO:0007263)
0.0	0.0	GO:0051135	regulation of NK T cell activation(GO:0051133) positive regulation of NK T cell activation(GO:0051135)
0.0	0.0	GO:0032228	regulation of synaptic transmission, GABAergic(GO:0032228)
0.0	0.0	GO:0035520	monoubiquitinated protein deubiquitination(GO:0035520)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.2	GO:0071664	catenin-TCF7L2 complex(GO:0071664)
0.1	0.4	GO:0032449	CBM complex(GO:0032449)
0.1	0.8	GO:0005915	zonula adherens(GO:0005915)
0.1	0.8	GO:0098642	network-forming collagen trimer(GO:0098642) collagen network(GO:0098645)
0.1	0.8	GO:0030122	AP-2 adaptor complex(GO:0030122) clathrin coat of endocytic vesicle(GO:0030128)
0.1	0.3	GO:0098647	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.1	0.2	GO:0030056	hemidesmosome(GO:0030056)
0.1	0.6	GO:0002102	podosome(GO:0002102)
0.1	0.8	GO:0043256	laminin complex(GO:0043256)
0.1	0.5	GO:0031143	pseudopodium(GO:0031143)
0.1	0.4	GO:0005593	FACIT collagen trimer(GO:0005593)
0.1	0.2	GO:0048179	activin receptor complex(GO:0048179)
0.1	0.3	GO:0036454	insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454)
0.1	0.1	GO:0098651	basement membrane collagen trimer(GO:0098651)
0.1	0.4	GO:0032588	trans-Golgi network membrane(GO:0032588)
0.1	0.2	GO:1990316	ATG1/ULK1 kinase complex(GO:1990316)
0.1	0.2	GO:0016327	apicolateral plasma membrane(GO:0016327)
0.1	0.3	GO:0016342	catenin complex(GO:0016342)
0.1	0.1	GO:0005899	insulin receptor complex(GO:0005899)
0.0	0.2	GO:0032059	bleb(GO:0032059)
0.0	0.1	GO:0071062	alphav-beta3 integrin-vitronectin complex(GO:0071062)
0.0	0.7	GO:0005581	collagen trimer(GO:0005581)
0.0	0.2	GO:0005828	kinetochore microtubule(GO:0005828)
0.0	0.4	GO:0030126	COPI vesicle coat(GO:0030126)
0.0	0.2	GO:0030061	mitochondrial crista(GO:0030061)
0.0	0.2	GO:0031512	motile primary cilium(GO:0031512)
0.0	2.8	GO:0005925	focal adhesion(GO:0005925)
0.0	0.1	GO:0031904	endosome lumen(GO:0031904)
0.0	0.2	GO:0031232	extrinsic component of external side of plasma membrane(GO:0031232)
0.0	0.2	GO:0031332	RISC complex(GO:0016442) RNAi effector complex(GO:0031332)
0.0	0.1	GO:0030121	AP-1 adaptor complex(GO:0030121)
0.0	0.2	GO:0001527	microfibril(GO:0001527)
0.0	0.1	GO:0042581	specific granule(GO:0042581)
0.0	0.3	GO:0071565	nBAF complex(GO:0071565)
0.0	0.1	GO:0030132	clathrin coat of coated pit(GO:0030132)
0.0	0.1	GO:0033646	host(GO:0018995) host cell part(GO:0033643) host intracellular part(GO:0033646) intracellular region of host(GO:0043656) host cell(GO:0043657) other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217)
0.0	0.1	GO:0000176	nuclear exosome (RNase complex)(GO:0000176)
0.0	0.1	GO:0005945	6-phosphofructokinase complex(GO:0005945)
0.0	0.1	GO:0031091	platelet alpha granule(GO:0031091)
0.0	0.1	GO:0017059	palmitoyltransferase complex(GO:0002178) serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0	0.1	GO:0031092	platelet alpha granule membrane(GO:0031092)
0.0	0.0	GO:0043083	synaptic cleft(GO:0043083)
0.0	0.4	GO:0032432	actin filament bundle(GO:0032432)
0.0	0.1	GO:0042622	photoreceptor outer segment membrane(GO:0042622)
0.0	0.0	GO:0043034	costamere(GO:0043034)
0.0	5.0	GO:0005578	proteinaceous extracellular matrix(GO:0005578)
0.0	0.0	GO:0014704	intercalated disc(GO:0014704) cell-cell contact zone(GO:0044291)
0.0	0.1	GO:0072669	tRNA-splicing ligase complex(GO:0072669)
0.0	0.1	GO:0036126	outer dense fiber(GO:0001520) sperm flagellum(GO:0036126)
0.0	0.7	GO:0031983	vesicle lumen(GO:0031983)
0.0	0.3	GO:0030867	rough endoplasmic reticulum membrane(GO:0030867)
0.0	0.1	GO:0016011	dystroglycan complex(GO:0016011) sarcoglycan complex(GO:0016012)
0.0	0.1	GO:0034673	inhibin-betaglycan-ActRII complex(GO:0034673)
0.0	0.1	GO:0005686	U2 snRNP(GO:0005686)
0.0	0.9	GO:0034707	chloride channel complex(GO:0034707)
0.0	0.1	GO:0070044	synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
0.0	0.1	GO:0031045	dense core granule(GO:0031045)
0.0	0.1	GO:0035253	ciliary rootlet(GO:0035253)
0.0	0.1	GO:0017146	NMDA selective glutamate receptor complex(GO:0017146)
0.0	0.2	GO:0005790	smooth endoplasmic reticulum(GO:0005790)
0.0	0.1	GO:0000444	MIS12/MIND type complex(GO:0000444)
0.0	0.3	GO:0080008	Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0	0.1	GO:0010369	chromocenter(GO:0010369)
0.0	0.0	GO:0001940	male pronucleus(GO:0001940)
0.0	0.0	GO:0042629	mast cell granule(GO:0042629)
0.0	0.2	GO:0034706	sodium channel complex(GO:0034706)
0.0	0.1	GO:0042587	glycogen granule(GO:0042587)
0.0	0.1	GO:0000940	condensed chromosome outer kinetochore(GO:0000940)
0.0	0.0	GO:0045254	pyruvate dehydrogenase complex(GO:0045254)
0.0	0.0	GO:0071778	obsolete WINAC complex(GO:0071778)
0.0	0.1	GO:0098878	ionotropic glutamate receptor complex(GO:0008328) neurotransmitter receptor complex(GO:0098878)
0.0	0.0	GO:0032809	neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0	0.1	GO:0035145	exon-exon junction complex(GO:0035145)
0.0	0.1	GO:0042575	DNA polymerase complex(GO:0042575)
0.0	0.3	GO:0030018	Z disc(GO:0030018)
0.0	0.2	GO:0005913	cell-cell adherens junction(GO:0005913)
0.0	0.0	GO:0051233	spindle midzone(GO:0051233)
0.0	0.2	GO:0019861	obsolete flagellum(GO:0019861)
0.0	0.1	GO:0005678	obsolete chromatin assembly complex(GO:0005678)
0.0	0.6	GO:0030017	sarcomere(GO:0030017)
0.0	0.1	GO:0030127	COPII vesicle coat(GO:0030127)
0.0	0.1	GO:0008385	IkappaB kinase complex(GO:0008385)
0.0	0.1	GO:0001739	sex chromatin(GO:0001739)
0.0	0.0	GO:0032777	Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0	0.1	GO:0031307	integral component of mitochondrial outer membrane(GO:0031307)
0.0	0.6	GO:0030427	site of polarized growth(GO:0030427)
0.0	0.1	GO:0000242	pericentriolar material(GO:0000242)
0.0	0.0	GO:0042405	nuclear inclusion body(GO:0042405)
0.0	0.4	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0	0.0	GO:0071564	npBAF complex(GO:0071564)
0.0	0.2	GO:0030057	desmosome(GO:0030057)
0.0	0.1	GO:0033162	melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.0	0.1	GO:0031305	integral component of mitochondrial inner membrane(GO:0031305)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.5	GO:0005229	intracellular calcium activated chloride channel activity(GO:0005229)
0.2	0.5	GO:0005006	epidermal growth factor-activated receptor activity(GO:0005006)
0.2	0.6	GO:0030297	transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.1	0.4	GO:0051371	muscle alpha-actinin binding(GO:0051371)
0.1	0.7	GO:0030618	transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.1	0.5	GO:0005010	insulin-like growth factor-activated receptor activity(GO:0005010)
0.1	0.4	GO:0004687	myosin light chain kinase activity(GO:0004687)
0.1	0.4	GO:0001099	basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.1	0.9	GO:0017166	vinculin binding(GO:0017166)
0.1	0.3	GO:0045545	syndecan binding(GO:0045545)
0.1	0.4	GO:0004849	uridine kinase activity(GO:0004849)
0.1	0.3	GO:0005017	platelet-derived growth factor-activated receptor activity(GO:0005017)
0.1	0.3	GO:0043398	HLH domain binding(GO:0043398)
0.1	0.3	GO:0042808	obsolete neuronal Cdc2-like kinase binding(GO:0042808)
0.1	0.2	GO:0015254	glycerol channel activity(GO:0015254)
0.1	0.2	GO:0008475	procollagen-lysine 5-dioxygenase activity(GO:0008475)
0.1	0.3	GO:0048018	receptor agonist activity(GO:0048018)
0.1	0.3	GO:0048495	Roundabout binding(GO:0048495)
0.1	0.6	GO:0047372	acylglycerol lipase activity(GO:0047372)
0.1	0.5	GO:0003708	retinoic acid receptor activity(GO:0003708)
0.1	0.3	GO:0015016	[heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.1	0.3	GO:0004470	malic enzyme activity(GO:0004470)
0.1	0.9	GO:0005523	tropomyosin binding(GO:0005523)
0.1	0.2	GO:0004705	JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.1	0.6	GO:0048407	platelet-derived growth factor binding(GO:0048407)
0.1	0.2	GO:0071553	uridine nucleotide receptor activity(GO:0015065) G-protein coupled pyrimidinergic nucleotide receptor activity(GO:0071553)
0.1	0.2	GO:0004157	dihydropyrimidinase activity(GO:0004157)
0.1	0.4	GO:0004908	interleukin-1 receptor activity(GO:0004908)
0.1	0.5	GO:0005024	transforming growth factor beta-activated receptor activity(GO:0005024)
0.1	0.2	GO:0016361	activin receptor activity, type I(GO:0016361)
0.1	0.2	GO:0016933	extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.1	0.3	GO:0031994	insulin-like growth factor I binding(GO:0031994)
0.1	0.1	GO:0005025	transforming growth factor beta receptor activity, type I(GO:0005025)
0.1	0.1	GO:0050682	AF-2 domain binding(GO:0050682)
0.1	0.2	GO:0045236	CXCR chemokine receptor binding(GO:0045236)
0.1	0.2	GO:0042978	ornithine decarboxylase activator activity(GO:0042978)
0.1	0.2	GO:0008140	cAMP response element binding protein binding(GO:0008140)
0.1	0.3	GO:0003956	NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
0.1	0.3	GO:0005172	vascular endothelial growth factor receptor binding(GO:0005172)
0.1	0.2	GO:0017162	aryl hydrocarbon receptor binding(GO:0017162)
0.1	0.2	GO:0030215	semaphorin receptor binding(GO:0030215)
0.1	0.2	GO:0008502	melatonin receptor activity(GO:0008502)
0.0	0.1	GO:0015204	urea transmembrane transporter activity(GO:0015204)
0.0	0.4	GO:0005112	Notch binding(GO:0005112)
0.0	0.2	GO:0004668	protein-arginine deiminase activity(GO:0004668)
0.0	0.1	GO:0005294	neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.0	0.1	GO:0070324	thyroid hormone binding(GO:0070324)
0.0	0.1	GO:0052834	inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate phosphatase activity(GO:0052834)
0.0	0.1	GO:0032296	ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296)
0.0	0.3	GO:0005110	frizzled-2 binding(GO:0005110)
0.0	0.2	GO:0010314	phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0	0.1	GO:0005078	MAP-kinase scaffold activity(GO:0005078)
0.0	0.3	GO:0070696	transmembrane receptor protein serine/threonine kinase binding(GO:0070696)
0.0	0.2	GO:0000293	ferric-chelate reductase activity(GO:0000293)
0.0	0.3	GO:0048185	activin binding(GO:0048185)
0.0	0.3	GO:0016713	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen(GO:0016713)
0.0	0.2	GO:0016721	superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.0	0.1	GO:0016623	oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor(GO:0016623)
0.0	0.1	GO:0050431	transforming growth factor beta binding(GO:0050431)
0.0	0.1	GO:0050501	hyaluronan synthase activity(GO:0050501)
0.0	0.3	GO:0030332	cyclin binding(GO:0030332)
0.0	0.1	GO:0043515	kinetochore binding(GO:0043515)
0.0	0.1	GO:0042289	MHC class II protein binding(GO:0042289)
0.0	0.1	GO:0003680	AT DNA binding(GO:0003680)
0.0	0.0	GO:0034416	bisphosphoglycerate phosphatase activity(GO:0034416)
0.0	0.3	GO:0031435	mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0	0.1	GO:0048027	mRNA 5'-UTR binding(GO:0048027)
0.0	0.5	GO:0016641	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641)
0.0	0.2	GO:0030020	extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.0	0.1	GO:0034186	apolipoprotein A-I binding(GO:0034186)
0.0	0.6	GO:0008603	cAMP-dependent protein kinase regulator activity(GO:0008603)
0.0	2.3	GO:0005201	extracellular matrix structural constituent(GO:0005201)
0.0	0.1	GO:0004862	cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0	0.1	GO:0019215	intermediate filament binding(GO:0019215)
0.0	0.2	GO:0004614	phosphoglucomutase activity(GO:0004614)
0.0	0.1	GO:0017154	semaphorin receptor activity(GO:0017154)
0.0	0.2	GO:0015057	thrombin receptor activity(GO:0015057)
0.0	0.1	GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.0	0.2	GO:0044390	ubiquitin conjugating enzyme binding(GO:0031624) ubiquitin-like protein conjugating enzyme binding(GO:0044390)
0.0	0.1	GO:0004828	serine-tRNA ligase activity(GO:0004828)
0.0	0.2	GO:0050811	GABA receptor binding(GO:0050811)
0.0	0.2	GO:0044548	S100 protein binding(GO:0044548)
0.0	0.2	GO:0008294	calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.0	0.1	GO:0004075	biotin carboxylase activity(GO:0004075)
0.0	0.4	GO:0042301	phosphate ion binding(GO:0042301)
0.0	0.2	GO:0015355	secondary active monocarboxylate transmembrane transporter activity(GO:0015355)
0.0	0.6	GO:0050840	extracellular matrix binding(GO:0050840)
0.0	0.3	GO:0050780	dopamine receptor binding(GO:0050780)
0.0	0.1	GO:0016454	serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0	0.1	GO:0003960	NADPH:quinone reductase activity(GO:0003960)
0.0	0.1	GO:0070095	fructose-6-phosphate binding(GO:0070095)
0.0	0.3	GO:0008106	alcohol dehydrogenase (NADP+) activity(GO:0008106)
0.0	0.2	GO:0030506	ankyrin binding(GO:0030506)
0.0	0.2	GO:0017080	sodium channel regulator activity(GO:0017080)
0.0	0.1	GO:0000309	nicotinamide-nucleotide adenylyltransferase activity(GO:0000309) nicotinate-nucleotide adenylyltransferase activity(GO:0004515)
0.0	0.1	GO:0015280	ligand-gated sodium channel activity(GO:0015280)
0.0	0.1	GO:0032554	purine deoxyribonucleotide binding(GO:0032554) adenyl deoxyribonucleotide binding(GO:0032558)
0.0	0.3	GO:0019894	kinesin binding(GO:0019894)
0.0	0.1	GO:0004322	ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0	0.1	GO:0035514	DNA demethylase activity(GO:0035514) DNA-N1-methyladenine dioxygenase activity(GO:0043734)
0.0	0.2	GO:0030274	LIM domain binding(GO:0030274)
0.0	0.4	GO:0005520	insulin-like growth factor binding(GO:0005520)
0.0	0.5	GO:0004683	calmodulin-dependent protein kinase activity(GO:0004683)
0.0	0.1	GO:0004461	lactose synthase activity(GO:0004461)
0.0	0.1	GO:0017112	Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0	0.3	GO:0051010	microtubule plus-end binding(GO:0051010)
0.0	0.1	GO:0004995	tachykinin receptor activity(GO:0004995)
0.0	0.1	GO:0043495	protein anchor(GO:0043495)
0.0	0.1	GO:0008401	retinoic acid 4-hydroxylase activity(GO:0008401)
0.0	0.2	GO:0016832	aldehyde-lyase activity(GO:0016832)
0.0	0.1	GO:0019238	cyclohydrolase activity(GO:0019238)
0.0	0.1	GO:0001515	opioid peptide activity(GO:0001515)
0.0	0.1	GO:0047429	nucleoside-triphosphate diphosphatase activity(GO:0047429)
0.0	1.3	GO:0004714	transmembrane receptor protein tyrosine kinase activity(GO:0004714)
0.0	0.1	GO:0031702	type 1 angiotensin receptor binding(GO:0031702)
0.0	0.2	GO:0043395	heparan sulfate proteoglycan binding(GO:0043395)
0.0	0.1	GO:0017169	CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.0	0.1	GO:0003872	6-phosphofructokinase activity(GO:0003872)
0.0	0.3	GO:0035035	histone acetyltransferase binding(GO:0035035)
0.0	0.0	GO:0005030	neurotrophin receptor activity(GO:0005030)
0.0	0.1	GO:0003986	acetyl-CoA hydrolase activity(GO:0003986)
0.0	0.1	GO:0017128	phospholipid scramblase activity(GO:0017128)
0.0	0.1	GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717)
0.0	0.1	GO:0004597	peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.0	0.1	GO:0008253	5'-nucleotidase activity(GO:0008253)
0.0	0.1	GO:0030346	protein phosphatase 2B binding(GO:0030346)
0.0	0.2	GO:0004065	arylsulfatase activity(GO:0004065)
0.0	0.1	GO:0005536	glucose binding(GO:0005536)
0.0	0.1	GO:0004937	alpha1-adrenergic receptor activity(GO:0004937)
0.0	0.1	GO:0043008	ATP-dependent protein binding(GO:0043008)
0.0	0.2	GO:0048038	quinone binding(GO:0048038)
0.0	0.1	GO:0034187	obsolete apolipoprotein E binding(GO:0034187)
0.0	0.1	GO:0070063	RNA polymerase binding(GO:0070063)
0.0	0.1	GO:0030492	hemoglobin binding(GO:0030492)
0.0	0.3	GO:0032393	MHC class I receptor activity(GO:0032393)
0.0	0.3	GO:0005247	voltage-gated chloride channel activity(GO:0005247)
0.0	0.1	GO:0043533	inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.0	0.0	GO:0016901	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor(GO:0016901)
0.0	0.1	GO:0009374	biotin binding(GO:0009374)
0.0	0.3	GO:0015269	calcium-activated potassium channel activity(GO:0015269)
0.0	0.1	GO:0009922	fatty acid elongase activity(GO:0009922)
0.0	0.1	GO:0004111	creatine kinase activity(GO:0004111)
0.0	0.1	GO:0030151	molybdenum ion binding(GO:0030151)
0.0	0.2	GO:0035255	ionotropic glutamate receptor binding(GO:0035255)
0.0	0.1	GO:0015467	G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0	0.1	GO:0016413	O-acetyltransferase activity(GO:0016413)
0.0	0.1	GO:0051920	peroxiredoxin activity(GO:0051920)
0.0	0.1	GO:0004030	aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.0	0.1	GO:0015220	choline transmembrane transporter activity(GO:0015220)
0.0	0.3	GO:0042813	Wnt-activated receptor activity(GO:0042813)
0.0	0.1	GO:0022839	ion gated channel activity(GO:0022839)
0.0	0.1	GO:0032794	GTPase activating protein binding(GO:0032794)
0.0	0.1	GO:0070576	vitamin D 24-hydroxylase activity(GO:0070576)
0.0	0.2	GO:0043498	obsolete cell surface binding(GO:0043498)
0.0	0.1	GO:0004844	uracil DNA N-glycosylase activity(GO:0004844) deaminated base DNA N-glycosylase activity(GO:0097506)
0.0	0.1	GO:0005332	gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.0	0.1	GO:0005148	prolactin receptor binding(GO:0005148)
0.0	0.7	GO:0008009	chemokine activity(GO:0008009)
0.0	0.0	GO:0002060	nucleobase binding(GO:0002054) purine nucleobase binding(GO:0002060)
0.0	0.0	GO:0008331	high voltage-gated calcium channel activity(GO:0008331)
0.0	0.0	GO:0046848	hydroxyapatite binding(GO:0046848)
0.0	0.0	GO:0033038	bitter taste receptor activity(GO:0033038)
0.0	0.1	GO:0004982	N-formyl peptide receptor activity(GO:0004982)
0.0	0.1	GO:0001671	ATPase activator activity(GO:0001671)
0.0	0.0	GO:0019959	C-X-C chemokine binding(GO:0019958) interleukin-8 binding(GO:0019959)
0.0	0.1	GO:0008312	7S RNA binding(GO:0008312)
0.0	0.4	GO:0004181	metallocarboxypeptidase activity(GO:0004181)
0.0	0.0	GO:0070996	type 1 melanocortin receptor binding(GO:0070996)
0.0	0.0	GO:0042577	lipid phosphatase activity(GO:0042577)
0.0	0.1	GO:0070717	poly-purine tract binding(GO:0070717)
0.0	0.1	GO:0030898	actin-dependent ATPase activity(GO:0030898)
0.0	0.2	GO:0004143	diacylglycerol kinase activity(GO:0004143)
0.0	0.0	GO:0019834	phospholipase A2 inhibitor activity(GO:0019834)
0.0	1.0	GO:0003777	microtubule motor activity(GO:0003777)
0.0	0.1	GO:0008526	phosphatidylinositol transporter activity(GO:0008526)
0.0	0.1	GO:0008649	rRNA methyltransferase activity(GO:0008649)
0.0	0.2	GO:0005242	inward rectifier potassium channel activity(GO:0005242)
0.0	0.1	GO:0042800	histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0	0.0	GO:0015168	glycerol transmembrane transporter activity(GO:0015168)
0.0	0.1	GO:0000832	inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832)
0.0	0.0	GO:0045499	chemorepellent activity(GO:0045499)
0.0	0.1	GO:0003711	obsolete transcription elongation regulator activity(GO:0003711)
0.0	0.1	GO:0004594	pantothenate kinase activity(GO:0004594)
0.0	0.3	GO:0008093	cytoskeletal adaptor activity(GO:0008093)
0.0	0.1	GO:0004033	aldo-keto reductase (NADP) activity(GO:0004033)
0.0	0.0	GO:0004769	steroid delta-isomerase activity(GO:0004769)
0.0	0.1	GO:0016595	glutamate binding(GO:0016595)
0.0	0.0	GO:0004144	diacylglycerol O-acyltransferase activity(GO:0004144)
0.0	0.1	GO:0017069	snRNA binding(GO:0017069)
0.0	0.1	GO:0016653	oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor(GO:0016653)
0.0	0.1	GO:0016868	intramolecular transferase activity, phosphotransferases(GO:0016868)
0.0	0.1	GO:0031369	translation initiation factor binding(GO:0031369)
0.0	0.0	GO:0005042	netrin receptor activity(GO:0005042)
0.0	0.1	GO:0019992	diacylglycerol binding(GO:0019992)
0.0	0.0	GO:0005534	galactose binding(GO:0005534)
0.0	0.1	GO:0004826	phenylalanine-tRNA ligase activity(GO:0004826)
0.0	0.0	GO:0016174	NAD(P)H oxidase activity(GO:0016174)
0.0	0.2	GO:0031683	G-protein beta/gamma-subunit complex binding(GO:0031683)
0.0	0.1	GO:0034483	heparan sulfate sulfotransferase activity(GO:0034483)
0.0	0.0	GO:0019763	immunoglobulin receptor activity(GO:0019763)
0.0	0.0	GO:0034056	estrogen response element binding(GO:0034056)
0.0	0.0	GO:0008046	axon guidance receptor activity(GO:0008046)
0.0	0.0	GO:0005283	sodium:amino acid symporter activity(GO:0005283)
0.0	0.0	GO:0004060	arylamine N-acetyltransferase activity(GO:0004060)
0.0	0.0	GO:0080030	methyl indole-3-acetate esterase activity(GO:0080030) methyl salicylate esterase activity(GO:0080031) methyl jasmonate esterase activity(GO:0080032)
0.0	0.2	GO:0004364	glutathione transferase activity(GO:0004364)
0.0	0.1	GO:0017110	nucleoside-diphosphatase activity(GO:0017110)
0.0	0.2	GO:0005184	neuropeptide hormone activity(GO:0005184)
0.0	0.0	GO:0004090	carbonyl reductase (NADPH) activity(GO:0004090)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
0.1	1.1	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.1	0.1	PID FAS PATHWAY	FAS (CD95) signaling pathway
0.1	0.1	PID LYMPH ANGIOGENESIS PATHWAY	VEGFR3 signaling in lymphatic endothelium
0.1	1.5	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
0.1	0.7	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.1	0.5	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1	2.4	NABA COLLAGENS	Genes encoding collagen proteins
0.0	1.4	PID INTEGRIN1 PATHWAY	Beta1 integrin cell surface interactions
0.0	0.1	PID ARF6 DOWNSTREAM PATHWAY	Arf6 downstream pathway
0.0	1.7	PID ECADHERIN STABILIZATION PATHWAY	Stabilization and expansion of the E-cadherin adherens junction
0.0	0.1	PID ECADHERIN KERATINOCYTE PATHWAY	E-cadherin signaling in keratinocytes
0.0	0.0	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0	0.1	PID A6B1 A6B4 INTEGRIN PATHWAY	a6b1 and a6b4 Integrin signaling
0.0	0.0	SA B CELL RECEPTOR COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0	0.1	PID AVB3 INTEGRIN PATHWAY	Integrins in angiogenesis
0.0	0.3	PID S1P S1P4 PATHWAY	S1P4 pathway
0.0	0.5	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0	0.9	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.0	0.2	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0	0.1	ST G ALPHA S PATHWAY	G alpha s Pathway
0.0	3.8	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.0	0.4	PID SYNDECAN 2 PATHWAY	Syndecan-2-mediated signaling events
0.0	0.3	PID HEDGEHOG 2PATHWAY	Signaling events mediated by the Hedgehog family
0.0	1.0	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.0	0.5	PID WNT SIGNALING PATHWAY	Wnt signaling network
0.0	0.5	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor
0.0	0.0	PID IGF1 PATHWAY	IGF1 pathway
0.0	0.4	PID UPA UPAR PATHWAY	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0	0.6	PID BMP PATHWAY	BMP receptor signaling
0.0	0.3	ST GRANULE CELL SURVIVAL PATHWAY	Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.0	0.1	SA PROGRAMMED CELL DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0	0.1	ST MYOCYTE AD PATHWAY	Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0	0.4	PID TGFBR PATHWAY	TGF-beta receptor signaling
0.0	0.1	PID ALK1 PATHWAY	ALK1 signaling events
0.0	0.2	ST G ALPHA I PATHWAY	G alpha i Pathway
0.0	0.0	PID ER NONGENOMIC PATHWAY	Plasma membrane estrogen receptor signaling
0.0	0.2	PID NCADHERIN PATHWAY	N-cadherin signaling events
0.0	0.1	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0	0.3	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.2	REACTOME PLC BETA MEDIATED EVENTS	Genes involved in PLC beta mediated events
0.1	1.1	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.1	1.7	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.1	0.7	REACTOME OTHER SEMAPHORIN INTERACTIONS	Genes involved in Other semaphorin interactions
0.0	2.8	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.0	0.0	REACTOME REGULATION OF APOPTOSIS	Genes involved in Regulation of Apoptosis
0.0	0.4	REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE	Genes involved in Synthesis of PIPs at the late endosome membrane
0.0	1.1	REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION	Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0	0.4	REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.0	1.0	REACTOME GRB2 EVENTS IN ERBB2 SIGNALING	Genes involved in GRB2 events in ERBB2 signaling
0.0	0.0	REACTOME DESTABILIZATION OF MRNA BY BRF1	Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.0	0.1	REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA	Genes involved in G beta:gamma signalling through PLC beta
0.0	1.0	REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS	Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0	0.3	REACTOME ERKS ARE INACTIVATED	Genes involved in ERKs are inactivated
0.0	0.5	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0	0.4	REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS	Genes involved in p130Cas linkage to MAPK signaling for integrins
0.0	0.8	REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS	Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.0	0.6	REACTOME SIGNALING BY BMP	Genes involved in Signaling by BMP
0.0	0.1	REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR	Genes involved in Signaling by constitutively active EGFR
0.0	0.3	REACTOME ROLE OF DCC IN REGULATING APOPTOSIS	Genes involved in Role of DCC in regulating apoptosis
0.0	0.3	REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII	Genes involved in CREB phosphorylation through the activation of CaMKII
0.0	0.3	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.0	0.2	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
0.0	0.3	REACTOME SIGNALING BY FGFR3 MUTANTS	Genes involved in Signaling by FGFR3 mutants
0.0	0.2	REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	Genes involved in DCC mediated attractive signaling
0.0	0.1	REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS	Genes involved in Activation of the AP-1 family of transcription factors
0.0	0.2	REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR	Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0	0.3	REACTOME ENDOGENOUS STEROLS	Genes involved in Endogenous sterols
0.0	0.1	REACTOME GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK	Genes involved in Gastrin-CREB signalling pathway via PKC and MAPK
0.0	0.2	REACTOME COMMON PATHWAY	Genes involved in Common Pathway
0.0	0.1	REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION	Genes involved in Influenza Viral RNA Transcription and Replication
0.0	0.2	REACTOME GAP JUNCTION DEGRADATION	Genes involved in Gap junction degradation
0.0	0.2	REACTOME RETROGRADE NEUROTROPHIN SIGNALLING	Genes involved in Retrograde neurotrophin signalling
0.0	0.4	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.0	0.1	REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES	Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0	0.0	REACTOME G ALPHA Z SIGNALLING EVENTS	Genes involved in G alpha (z) signalling events
0.0	0.0	REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS	Genes involved in Nucleotide-like (purinergic) receptors
0.0	0.1	REACTOME ADP SIGNALLING THROUGH P2RY12	Genes involved in ADP signalling through P2Y purinoceptor 12
0.0	0.3	REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS	Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0	0.1	REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY	Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0	0.5	REACTOME AMINE COMPOUND SLC TRANSPORTERS	Genes involved in Amine compound SLC transporters
0.0	0.2	REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS	Genes involved in Tandem pore domain potassium channels
0.0	0.0	REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR	Genes involved in Prostacyclin signalling through prostacyclin receptor
0.0	0.0	REACTOME DESTABILIZATION OF MRNA BY KSRP	Genes involved in Destabilization of mRNA by KSRP
0.0	1.1	REACTOME CELL JUNCTION ORGANIZATION	Genes involved in Cell junction organization
0.0	0.4	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.0	0.0	REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.0	0.0	REACTOME CIRCADIAN CLOCK	Genes involved in Circadian Clock
0.0	0.3	REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION	Genes involved in Amino acid synthesis and interconversion (transamination)
0.0	0.2	REACTOME PURINE CATABOLISM	Genes involved in Purine catabolism
0.0	0.0	REACTOME SYNTHESIS OF PA	Genes involved in Synthesis of PA
0.0	0.2	REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE	Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0	0.3	REACTOME SIGNALING BY ROBO RECEPTOR	Genes involved in Signaling by Robo receptor
0.0	0.3	REACTOME RESOLUTION OF AP SITES VIA THE MULTIPLE NUCLEOTIDE PATCH REPLACEMENT PATHWAY	Genes involved in Resolution of AP sites via the multiple-nucleotide patch replacement pathway
0.0	0.0	REACTOME SEMA3A PAK DEPENDENT AXON REPULSION	Genes involved in Sema3A PAK dependent Axon repulsion
0.0	0.0	REACTOME SOS MEDIATED SIGNALLING	Genes involved in SOS-mediated signalling
0.0	0.2	REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS	Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.0	0.3	REACTOME HS GAG BIOSYNTHESIS	Genes involved in HS-GAG biosynthesis
0.0	0.1	REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS	Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0	0.1	REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC	Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.0	0.3	REACTOME GLUTATHIONE CONJUGATION	Genes involved in Glutathione conjugation
0.0	0.3	REACTOME GLYCOLYSIS	Genes involved in Glycolysis
0.0	0.0	REACTOME RNA POL I PROMOTER OPENING	Genes involved in RNA Polymerase I Promoter Opening
0.0	0.3	REACTOME PYRIMIDINE METABOLISM	Genes involved in Pyrimidine metabolism
0.0	0.1	REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING	Genes involved in Role of second messengers in netrin-1 signaling
0.0	0.3	REACTOME LIGAND GATED ION CHANNEL TRANSPORT	Genes involved in Ligand-gated ion channel transport
0.0	0.1	REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Glutamate Neurotransmitter Release Cycle
0.0	0.2	REACTOME STEROID HORMONES	Genes involved in Steroid hormones
0.0	0.1	REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION	Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0	0.0	REACTOME APC C CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS	Genes involved in APC/C:Cdc20 mediated degradation of mitotic proteins
0.0	0.1	REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL	Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.0	0.2	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions

Results for SMAD3

Z-value: 1.73

Motif logo

Transcription factors associated with SMAD3

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Activity of the SMAD3 motif across conditions

Conditions sorted by the z-value of the SMAD3 motif activity

Top target CREs of the motif:

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of SMAD3

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: