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ENCODE: H3K4me1 ChIP-Seq of primary human cells
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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for SOX1

Z-value: 1.22

Motif logo

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Transcription factors associated with SOX1

Gene Symbol Gene ID Gene Info
SOX1
ENSG00000182968.3 SOX1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
SOX1chr13_112720418_11272056914200.503494-0.835.7e-03Click!
SOX1chr13_112728491_11272864266530.262784-0.665.3e-02Click!
SOX1chr13_112727676_11272782758380.268103-0.627.6e-02Click!
SOX1chr13_112717574_11271772542640.279595-0.541.4e-01Click!
SOX1chr13_112719784_11271993520540.393963-0.511.6e-01Click!

Activity of the SOX1 motif across conditions

Conditions sorted by the z-value of the SOX1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr4_119840255_119840406 0.38 SYNPO2
 synaptopodin 2
 30138
 0.22
chr9_139592974_139593244 0.37 ENSG00000221693
 .
 4521
 0.09
chr12_2722252_2722403 0.34 CACNA1C-AS3
 CACNA1C antisense RNA 3
 5721
 0.25
chr3_156958058_156958281 0.34 ENSG00000243176
 .
 10101
 0.23
chr2_145233839_145234118 0.32 ZEB2
 zinc finger E-box binding homeobox 2
 41137
 0.18
chr8_24206460_24207135 0.32 ADAM28
 ADAM metallopeptidase domain 28
 7632
 0.22
chr5_82844689_82844840 0.32 VCAN-AS1
 VCAN antisense RNA 1
 13369
 0.26
chr3_151081140_151081291 0.32 P2RY12
 purinergic receptor P2Y, G-protein coupled, 12
 21385
 0.16
chr5_17441386_17441790 0.32 ENSG00000201715
 .
 95863
 0.09
chr14_81777385_81777871 0.31 STON2
 stonin 2
 34351
 0.21
chr4_26203211_26203362 0.31 RBPJ
 recombination signal binding protein for immunoglobulin kappa J region
 38209
 0.23
chr4_170063847_170063998 0.31 RP11-327O17.2
59023
 0.13
chr17_72829977_72830202 0.31 GRIN2C
 glutamate receptor, ionotropic, N-methyl D-aspartate 2C
 25909
 0.1
chr12_63139153_63139473 0.30 ENSG00000238475
 .
 94358
 0.07
chr3_132166945_132167174 0.30 DNAJC13
 DnaJ (Hsp40) homolog, subfamily C, member 13
 30689
 0.21
chr9_79075654_79076239 0.30 GCNT1
 glucosaminyl (N-acetyl) transferase 1, core 2
 1800
 0.46
chr9_75758402_75758816 0.30 ANXA1
 annexin A1
 8064
 0.29
chr1_220991673_220991824 0.30 ENSG00000221571
 .
 7370
 0.19
chr3_152215781_152215932 0.29 RP11-362A9.3
1254
 0.56
chr16_87235774_87235925 0.29 RP11-899L11.3
13672
 0.22
chr10_79362350_79362775 0.28 ENSG00000199592
 .
 15755
 0.23
chr7_137627516_137627793 0.28 CREB3L2
 cAMP responsive element binding protein 3-like 2
 9018
 0.21
chr11_94270106_94270257 0.28 FUT4
 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
 6836
 0.17
chr2_9123063_9123286 0.28 ENSG00000238888
 .
 4150
 0.28
chr18_52996058_52996412 0.28 TCF4
 transcription factor 4
 6710
 0.3
chr8_121255984_121256342 0.27 COL14A1
 collagen, type XIV, alpha 1
 47008
 0.19
chr2_109840568_109840719 0.27 ENSG00000264934
 .
 82599
 0.09
chr13_75343971_75344251 0.27 ENSG00000206812
 .
 339613
 0.01
chr7_30473070_30473306 0.27 GS1-114I9.1
8900
 0.22
chr9_128640336_128640592 0.27 PBX3
 pre-B-cell leukemia homeobox 3
 12914
 0.3
chr17_28276059_28276214 0.27 EFCAB5
 EF-hand calcium binding domain 5
 7513
 0.16
chr8_97603049_97603490 0.27 SDC2
 syndecan 2
 4654
 0.31
chr4_74570740_74571087 0.27 IL8
 interleukin 8
 35310
 0.18
chr12_2404699_2404850 0.27 CACNA1C-IT3
 CACNA1C intronic transcript 3 (non-protein coding)
 25832
 0.23
chr8_119820459_119820610 0.27 TNFRSF11B
 tumor necrosis factor receptor superfamily, member 11b
 143905
 0.05
chr4_140868395_140868609 0.27 MAML3
 mastermind-like 3 (Drosophila)
 56381
 0.15
chr11_122129149_122129397 0.27 RP11-716H6.2
36625
 0.18
chr8_131449622_131449982 0.27 ASAP1
 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
 6104
 0.34
chr5_111170644_111170932 0.26 NREP
 neuronal regeneration related protein
 76873
 0.1
chr18_10213374_10213664 0.26 ENSG00000239031
 .
 176478
 0.03
chr12_1888807_1888958 0.26 CACNA2D4
 calcium channel, voltage-dependent, alpha 2/delta subunit 4
 32004
 0.16
chr16_90087017_90087313 0.26 DBNDD1
 dysbindin (dystrobrevin binding protein 1) domain containing 1
 629
 0.49
chr5_37662246_37662397 0.26 ENSG00000206743
 .
 38218
 0.18
chr16_80813095_80813246 0.25 CDYL2
 chromodomain protein, Y-like 2
 24990
 0.19
chr15_49531132_49531283 0.25 ENSG00000243338
 .
 39816
 0.14
chr13_102034548_102034699 0.25 NALCN
 sodium leak channel, non-selective
 16882
 0.28
chr1_203172034_203172338 0.25 CHI3L1
 chitinase 3-like 1 (cartilage glycoprotein-39)
 16309
 0.13
chr2_224329886_224330037 0.25 SCG2
 secretogranin II
 137041
 0.05
chr8_120666856_120667007 0.25 ENPP2
 ectonucleotide pyrophosphatase/phosphodiesterase 2
 15852
 0.23
chr1_162680781_162680932 0.25 DDR2
 discoidin domain receptor tyrosine kinase 2
 56171
 0.12
chr1_25062834_25063115 0.25 CLIC4
 chloride intracellular channel 4
 8874
 0.21
chr9_14361056_14361207 0.25 RP11-120J1.1
13812
 0.26
chr9_133737039_133737190 0.25 ABL1
 c-abl oncogene 1, non-receptor tyrosine kinase
 26661
 0.16
chr3_193398167_193398329 0.25 OPA1
 optic atrophy 1 (autosomal dominant)
 13283
 0.2
chr8_108825138_108825289 0.25 ENSG00000200806
 .
 71509
 0.13
chr2_145184442_145184602 0.24 ZEB2
 zinc finger E-box binding homeobox 2
 3071
 0.37
chr5_169227490_169227641 0.24 CTB-37A13.1
21196
 0.23
chr17_66377035_66377186 0.24 ENSG00000207561
 .
 43579
 0.13
chr7_27439570_27439956 0.24 EVX1-AS
 EVX1 antisense RNA
 152915
 0.03
chr3_141051448_141051599 0.24 ZBTB38
 zinc finger and BTB domain containing 38
 8468
 0.23
chr7_81267105_81267256 0.24 HGF
 hepatocyte growth factor (hepapoietin A; scatter factor)
 125132
 0.06
chr18_42871797_42872157 0.24 SLC14A2
 solute carrier family 14 (urea transporter), member 2
 79017
 0.1
chr5_157940975_157941126 0.24 CTD-2363C16.1
468964
 0.01
chr3_145789789_145789940 0.24 RP11-274H2.3
2892
 0.2
chr14_72049969_72050208 0.24 SIPA1L1
 signal-induced proliferation-associated 1 like 1
 2910
 0.4
chr10_28338247_28338398 0.23 ARMC4
 armadillo repeat containing 4
 50345
 0.18
chr21_39659541_39659821 0.23 KCNJ15
 potassium inwardly-rectifying channel, subfamily J, member 15
 8798
 0.29
chr10_119190700_119190851 0.23 EMX2OS
 EMX2 opposite strand/antisense RNA
 45909
 0.14
chr4_140128476_140128652 0.23 ENSG00000207384
 .
 7015
 0.14
chr5_138129356_138129507 0.23 CTNNA1
 catenin (cadherin-associated protein), alpha 1, 102kDa
 11819
 0.18
chr6_147360995_147361146 0.23 STXBP5-AS1
 STXBP5 antisense RNA 1
 79529
 0.12
chr7_94028721_94028872 0.23 COL1A2
 collagen, type I, alpha 2
 4923
 0.31
chr5_54205741_54205892 0.23 RP11-45H22.3
 Uncharacterized protein
 47858
 0.13
chr3_43995198_43995349 0.23 ENSG00000252980
 .
 117306
 0.06
chr1_93659807_93659958 0.23 CCDC18
 coiled-coil domain containing 18
 11230
 0.19
chr7_36321270_36321473 0.23 EEPD1
 endonuclease/exonuclease/phosphatase family domain containing 1
 15382
 0.18
chr2_73361224_73361375 0.23 RAB11FIP5
 RAB11 family interacting protein 5 (class I)
 21153
 0.15
chr1_67215420_67215716 0.23 TCTEX1D1
 Tctex1 domain containing 1
 2575
 0.25
chr3_37156478_37156973 0.23 ENSG00000206645
 .
 22000
 0.14
chr8_131231626_131231777 0.23 ASAP1
 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
 27587
 0.22
chr4_74877754_74877905 0.23 ENSG00000244194
 .
 534
 0.69
chr2_191910102_191910403 0.23 ENSG00000231858
 .
 24000
 0.15
chr2_225885403_225885713 0.23 ENSG00000263828
 .
 10301
 0.26
chr13_95512353_95512659 0.23 SOX21
 SRY (sex determining region Y)-box 21
 148117
 0.04
chr2_224835251_224835402 0.22 AC073641.2
2903
 0.25
chr3_48260439_48260590 0.22 CAMP
 cathelicidin antimicrobial peptide
 4323
 0.14
chr1_186072322_186072473 0.22 HMCN1
 hemicentin 1
 68122
 0.12
chr16_8727737_8727888 0.22 METTL22
 methyltransferase like 22
 7183
 0.2
chr4_14126776_14126991 0.22 ENSG00000252092
 .
 466632
 0.01
chr1_38971877_38972028 0.22 ENSG00000200796
 .
 109621
 0.07
chr14_35316852_35317003 0.22 ENSG00000251726
 .
 2361
 0.26
chr15_63322062_63322250 0.22 TPM1
 tropomyosin 1 (alpha)
 12675
 0.18
chr17_32575781_32575932 0.22 CCL2
 chemokine (C-C motif) ligand 2
 6448
 0.14
chr6_107666321_107666494 0.21 PDSS2
 prenyl (decaprenyl) diphosphate synthase, subunit 2
 114353
 0.06
chr1_157969918_157970069 0.21 KIRREL
 kin of IRRE like (Drosophila)
 6558
 0.23
chr13_51502962_51503330 0.21 RNASEH2B-AS1
 RNASEH2B antisense RNA 1
 18298
 0.19
chr5_131009053_131009204 0.21 RAPGEF6
 Rap guanine nucleotide exchange factor (GEF) 6
 38199
 0.2
chr3_177233798_177234049 0.21 ENSG00000252028
 .
 12583
 0.3
chr12_56988475_56988626 0.21 ENSG00000201579
 .
 6248
 0.14
chr11_58666569_58666720 0.21 AP001652.1
 Uncharacterized protein; cDNA FLJ60524
 6253
 0.16
chr10_60263837_60263988 0.21 BICC1
 bicaudal C homolog 1 (Drosophila)
 8988
 0.3
chr12_128113022_128113173 0.21 ENSG00000199584
 .
 9105
 0.33
chr1_170547448_170547599 0.21 RP11-576I22.2
45735
 0.15
chr15_89682572_89682723 0.21 ENSG00000239151
 .
 18637
 0.17
chr7_41900994_41901505 0.21 AC005027.3
156316
 0.04
chr5_158532260_158532809 0.21 EBF1
 early B-cell factor 1
 5765
 0.27
chr6_135201950_135202101 0.21 ALDH8A1
 aldehyde dehydrogenase 8 family, member A1
 48274
 0.16
chr6_7567563_7567714 0.21 SNRNP48
 small nuclear ribonucleoprotein 48kDa (U11/U12)
 22794
 0.17
chr11_46315736_46316001 0.21 CREB3L1
 cAMP responsive element binding protein 3-like 1
 809
 0.61
chr2_216519335_216519486 0.21 AC012462.1
218434
 0.02
chr6_6751273_6751724 0.21 LY86-AS1
 LY86 antisense RNA 1
 128494
 0.05
chr3_194229123_194229359 0.21 AC108676.1
7009
 0.15
chr4_80130432_80130713 0.21 LINC01088
 long intergenic non-protein coding RNA 1088
 2263
 0.44
chr12_1689048_1689199 0.21 WNT5B
 wingless-type MMTV integration site family, member 5B
 5300
 0.23
chr10_69597546_69597697 0.21 DNAJC12
 DnaJ (Hsp40) homolog, subfamily C, member 12
 196
 0.94
chr12_68663185_68663336 0.20 IL22
 interleukin 22
 15873
 0.2
chr1_178977288_178977439 0.20 FAM20B
 family with sequence similarity 20, member B
 17576
 0.22
chr17_67497077_67497228 0.20 MAP2K6
 mitogen-activated protein kinase kinase 6
 1143
 0.65
chr12_49617152_49617303 0.20 TUBA1C
 tubulin, alpha 1c
 4482
 0.14
chr7_107744575_107744726 0.20 LAMB4
 laminin, beta 4
 26150
 0.19
chr7_127434231_127434382 0.20 SND1
 staphylococcal nuclease and tudor domain containing 1
 93659
 0.08
chr22_29480422_29480573 0.20 KREMEN1
 kringle containing transmembrane protein 1
 11378
 0.14
chr15_99366654_99366903 0.20 ENSG00000264480
 .
 39123
 0.17
chr7_137353876_137354027 0.20 DGKI
 diacylglycerol kinase, iota
 177331
 0.03
chr15_35917883_35918034 0.20 DPH6
 diphthamine biosynthesis 6
 79565
 0.12
chr20_3022724_3022875 0.20 GNRH2
 gonadotropin-releasing hormone 2
 1469
 0.3
chr3_191095252_191095403 0.20 UTS2B
 urotensin 2B
 47002
 0.15
chr17_39441247_39441419 0.20 KRTAP9-7
 keratin associated protein 9-7
 9422
 0.07
chr9_110631347_110631608 0.20 ENSG00000222459
 .
 49782
 0.14
chr3_196931709_196931860 0.20 DLG1
 discs, large homolog 1 (Drosophila)
 20782
 0.21
chr13_46915131_46915547 0.20 ENSG00000223336
 .
 33386
 0.15
chr16_67150350_67150513 0.20 C16orf70
 chromosome 16 open reading frame 70
 6381
 0.11
chr20_35470625_35470932 0.20 SOGA1
 suppressor of glucose, autophagy associated 1
 17498
 0.15
chr5_122891005_122891156 0.20 CSNK1G3
 casein kinase 1, gamma 3
 9752
 0.27
chr7_42644591_42644742 0.20 C7orf25
 chromosome 7 open reading frame 25
 306843
 0.01
chr2_64454414_64454565 0.20 AC074289.1
506
 0.86
chr14_59054467_59054618 0.20 DACT1
 dishevelled-binding antagonist of beta-catenin 1
 46244
 0.16
chr17_15141377_15141528 0.20 ENSG00000238806
 .
 252
 0.91
chr2_158866139_158866424 0.20 UPP2
 uridine phosphorylase 2
 14570
 0.21
chr14_56591619_56591920 0.19 PELI2
 pellino E3 ubiquitin protein ligase family member 2
 5942
 0.27
chr22_38887629_38887898 0.19 DDX17
 DEAD (Asp-Glu-Ala-Asp) box helicase 17
 3228
 0.19
chr2_65068622_65068773 0.19 ENSG00000199964
 .
 7406
 0.19
chr8_123443650_123443801 0.19 ENSG00000238901
 .
 239805
 0.02
chr8_104241607_104241758 0.19 RP11-318M2.3
140
 0.96
chr11_111689927_111690130 0.19 ALG9-IT1
 ALG9 intronic transcript 1 (non-protein coding)
 9908
 0.14
chr16_67313528_67313920 0.19 PLEKHG4
 pleckstrin homology domain containing, family G (with RhoGef domain) member 4
 225
 0.85
chr13_42267553_42267704 0.19 ENSG00000241406
 .
 114185
 0.06
chr5_134718854_134719146 0.19 H2AFY
 H2A histone family, member Y
 15901
 0.16
chr18_59997160_59997754 0.19 ENSG00000199867
 .
 588
 0.71
chr17_30065927_30066078 0.19 ENSG00000202026
 .
 25230
 0.2
chr20_48270908_48271059 0.19 B4GALT5
 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
 59432
 0.1
chr22_28979388_28979539 0.19 ENSG00000266503
 .
 59795
 0.12
chr7_90957018_90957310 0.19 FZD1
 frizzled family receptor 1
 63381
 0.16
chr2_38025271_38025480 0.19 CDC42EP3
 CDC42 effector protein (Rho GTPase binding) 3
 59764
 0.14
chr2_192249045_192249196 0.19 MYO1B
 myosin IB
 7740
 0.25
chr7_28125604_28125755 0.19 JAZF1
 JAZF zinc finger 1
 14376
 0.23
chr12_43709758_43710210 0.19 ENSG00000215993
 .
 24601
 0.27
chr11_9916771_9916922 0.19 ENSG00000252568
 .
 51423
 0.12
chr11_4138956_4139107 0.19 RRM1
 ribonucleotide reductase M1
 1558
 0.4
chr3_65934751_65934914 0.19 MAGI1-IT1
 MAGI1 intronic transcript 1 (non-protein coding)
 5401
 0.21
chr1_171820085_171820236 0.19 DNM3
 dynamin 3
 9491
 0.18
chr11_5385954_5386105 0.19 OR51B6
 olfactory receptor, family 51, subfamily B, member 6
 13291
 0.1
chr11_32078115_32078502 0.19 RP1-17K7.3
3502
 0.18
chr3_106579769_106579920 0.19 ENSG00000252626
 .
 146571
 0.05
chr8_9567180_9567331 0.19 ENSG00000207701
 .
 31927
 0.2
chr1_228832975_228833126 0.19 RHOU
 ras homolog family member U
 37774
 0.06
chr6_7731429_7731580 0.19 BMP6
 bone morphogenetic protein 6
 4474
 0.33
chr15_31515349_31515542 0.19 TRPM1
 transient receptor potential cation channel, subfamily M, member 1
 61969
 0.13
chr17_62251813_62252075 0.19 ENSG00000266402
 .
 28245
 0.13
chr12_66421418_66421618 0.19 ENSG00000251857
 .
 38483
 0.15
chr18_32230366_32230628 0.19 DTNA
 dystrobrevin, alpha
 29004
 0.24
chr7_14787273_14787554 0.19 ENSG00000221428
 .
 27618
 0.23
chr17_30005749_30005900 0.19 ENSG00000202026
 .
 34948
 0.15
chr12_27242184_27242645 0.18 C12orf71
 chromosome 12 open reading frame 71
 6967
 0.23
chr14_53521128_53521279 0.18 RP11-368P15.3
17730
 0.23
chr6_109195578_109195936 0.18 ARMC2
 armadillo repeat containing 2
 5576
 0.27
chr8_57701142_57701293 0.18 ENSG00000206975
 .
 128426
 0.06
chr8_121275153_121275304 0.18 COL14A1
 collagen, type XIV, alpha 1
 66073
 0.14
chr14_88892580_88892731 0.18 SPATA7
 spermatogenesis associated 7
 4860
 0.24
chr17_905516_905973 0.18 TIMM22
 translocase of inner mitochondrial membrane 22 homolog (yeast)
 5387
 0.15
chr11_32077877_32078028 0.18 RP1-17K7.3
3146
 0.19
chr5_38608192_38608343 0.18 LIFR
 leukemia inhibitory factor receptor alpha
 12761
 0.21
chr8_97846985_97847178 0.18 CPQ
 carboxypeptidase Q
 73613
 0.13
chr2_144844328_144844479 0.18 GTDC1
 glycosyltransferase-like domain containing 1
 148901
 0.04
chr6_147409086_147409237 0.18 STXBP5-AS1
 STXBP5 antisense RNA 1
 31438
 0.24
chr3_122090436_122090587 0.18 CCDC58
 coiled-coil domain containing 58
 1358
 0.37
chr1_108477784_108478012 0.18 VAV3-AS1
 VAV3 antisense RNA 1
 29167
 0.19
chr2_10119770_10119921 0.18 GRHL1
 grainyhead-like 1 (Drosophila)
 15589
 0.16
chr5_158203769_158203920 0.18 CTD-2363C16.1
206170
 0.03
chr2_86006975_86007126 0.18 ATOH8
 atonal homolog 8 (Drosophila)
 26033
 0.13
chr5_17260833_17260984 0.18 ENSG00000252908
 .
 20188
 0.19
chr5_102771863_102772014 0.18 NUDT12
 nudix (nucleoside diphosphate linked moiety X)-type motif 12
 126552
 0.06
chr15_42750888_42751039 0.18 ZNF106
 zinc finger protein 106
 1209
 0.41
chr8_107985728_107985879 0.18 ABRA
 actin-binding Rho activating protein
 203330
 0.03
chr2_106647459_106647648 0.18 C2orf40
 chromosome 2 open reading frame 40
 32197
 0.22
chr2_236526424_236526721 0.18 ENSG00000221704
 .
 45997
 0.16
chr21_16295742_16295893 0.18 AF127577.8
4962
 0.25
chr21_15940800_15940951 0.18 SAMSN1-AS1
 SAMSN1 antisense RNA 1
 13648
 0.21
chr7_41087768_41087919 0.18 AC005160.3
272686
 0.02
chr13_36698254_36698405 0.18 DCLK1
 doublecortin-like kinase 1
 7114
 0.28

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

StringDB image

First level regulatory network of SOX1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0045425 positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process(GO:0045425)
0.0 0.3 GO:0060997 dendritic spine morphogenesis(GO:0060997) regulation of dendritic spine morphogenesis(GO:0061001) dendritic spine organization(GO:0097061)
0.0 0.1 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.0 0.2 GO:0043116 negative regulation of vascular permeability(GO:0043116)
0.0 0.1 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.0 0.1 GO:0019471 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) 4-hydroxyproline metabolic process(GO:0019471) peptidyl-proline hydroxylation(GO:0019511)
0.0 0.1 GO:0070208 protein heterotrimerization(GO:0070208)
0.0 0.1 GO:0010842 retina layer formation(GO:0010842)
0.0 0.1 GO:0071692 sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.0 0.1 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 0.0 GO:0002072 optic cup morphogenesis involved in camera-type eye development(GO:0002072)
0.0 0.1 GO:0010566 regulation of ketone biosynthetic process(GO:0010566) regulation of aldosterone metabolic process(GO:0032344) regulation of aldosterone biosynthetic process(GO:0032347)
0.0 0.1 GO:0071731 response to nitric oxide(GO:0071731)
0.0 0.1 GO:0060437 lung growth(GO:0060437)
0.0 0.1 GO:0048245 eosinophil chemotaxis(GO:0048245) eosinophil migration(GO:0072677)
0.0 0.1 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
0.0 0.0 GO:0010193 response to ozone(GO:0010193)
0.0 0.1 GO:0006931 substrate-dependent cell migration, cell attachment to substrate(GO:0006931)
0.0 0.4 GO:0021846 cell proliferation in forebrain(GO:0021846)
0.0 0.2 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.0 0.1 GO:0016102 retinoic acid biosynthetic process(GO:0002138) diterpenoid biosynthetic process(GO:0016102)
0.0 0.1 GO:0070874 negative regulation of glycogen metabolic process(GO:0070874)
0.0 0.1 GO:0017121 phospholipid scrambling(GO:0017121)
0.0 0.2 GO:0047497 establishment of mitochondrion localization, microtubule-mediated(GO:0034643) mitochondrion transport along microtubule(GO:0047497)
0.0 0.0 GO:0030538 embryonic genitalia morphogenesis(GO:0030538)
0.0 0.1 GO:0051788 response to misfolded protein(GO:0051788)
0.0 0.1 GO:0046784 viral mRNA export from host cell nucleus(GO:0046784)
0.0 0.1 GO:0060605 tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662)
0.0 0.0 GO:0034139 regulation of toll-like receptor 3 signaling pathway(GO:0034139)
0.0 0.1 GO:0016322 neuron remodeling(GO:0016322)
0.0 0.1 GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0043619)
0.0 0.1 GO:0042119 neutrophil activation(GO:0042119)
0.0 0.0 GO:0001996 positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996)
0.0 0.1 GO:0007386 compartment pattern specification(GO:0007386)
0.0 0.0 GO:0006565 L-serine catabolic process(GO:0006565)
0.0 0.1 GO:0071221 response to bacterial lipoprotein(GO:0032493) response to bacterial lipopeptide(GO:0070339) cellular response to bacterial lipoprotein(GO:0071220) cellular response to bacterial lipopeptide(GO:0071221)
0.0 0.0 GO:0007621 negative regulation of female receptivity(GO:0007621)
0.0 0.1 GO:0010591 regulation of lamellipodium assembly(GO:0010591)
0.0 0.1 GO:0071168 protein localization to chromatin(GO:0071168)
0.0 0.0 GO:0071277 cellular response to calcium ion(GO:0071277)
0.0 0.0 GO:2000095 regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000095)
0.0 0.0 GO:0033603 positive regulation of dopamine secretion(GO:0033603)
0.0 0.1 GO:0001547 antral ovarian follicle growth(GO:0001547)
0.0 0.0 GO:0060996 dendritic spine development(GO:0060996)
0.0 0.0 GO:0002606 positive regulation of dendritic cell antigen processing and presentation(GO:0002606)
0.0 0.1 GO:0070245 positive regulation of T cell apoptotic process(GO:0070234) positive regulation of thymocyte apoptotic process(GO:0070245)
0.0 0.0 GO:0071224 cellular response to peptidoglycan(GO:0071224)
0.0 0.0 GO:0001766 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.0 0.0 GO:0010587 miRNA metabolic process(GO:0010586) miRNA catabolic process(GO:0010587)
0.0 0.0 GO:0060083 smooth muscle contraction involved in micturition(GO:0060083)
0.0 0.0 GO:0045578 negative regulation of B cell differentiation(GO:0045578)
0.0 0.0 GO:0034371 chylomicron remodeling(GO:0034371)
0.0 0.0 GO:0046121 deoxyribonucleoside catabolic process(GO:0046121)
0.0 0.1 GO:0045989 positive regulation of striated muscle contraction(GO:0045989)
0.0 0.1 GO:0045618 positive regulation of keratinocyte differentiation(GO:0045618)
0.0 0.0 GO:0007132 meiotic metaphase I(GO:0007132)
0.0 0.0 GO:0006883 cellular sodium ion homeostasis(GO:0006883)
0.0 0.1 GO:0006857 oligopeptide transport(GO:0006857)
0.0 0.0 GO:0007412 axon target recognition(GO:0007412)
0.0 0.0 GO:0070572 positive regulation of axon regeneration(GO:0048680) positive regulation of neuron projection regeneration(GO:0070572)
0.0 0.0 GO:0060028 convergent extension involved in axis elongation(GO:0060028)
0.0 0.0 GO:0031125 rRNA 3'-end processing(GO:0031125)
0.0 0.1 GO:0051290 protein heterotetramerization(GO:0051290)
0.0 0.1 GO:0019673 GDP-mannose metabolic process(GO:0019673)
0.0 0.1 GO:0008228 opsonization(GO:0008228)
0.0 0.1 GO:0034446 substrate adhesion-dependent cell spreading(GO:0034446)
0.0 0.1 GO:0048208 vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208) COPII-coated vesicle budding(GO:0090114)
0.0 0.0 GO:0051852 disruption by host of symbiont cells(GO:0051852) killing by host of symbiont cells(GO:0051873)
0.0 0.1 GO:0006975 DNA damage induced protein phosphorylation(GO:0006975)
0.0 0.0 GO:0002689 negative regulation of leukocyte chemotaxis(GO:0002689)
0.0 0.0 GO:0060753 mast cell chemotaxis(GO:0002551) regulation of mast cell chemotaxis(GO:0060753) positive regulation of mast cell chemotaxis(GO:0060754) mast cell migration(GO:0097531)
0.0 0.1 GO:0060259 regulation of feeding behavior(GO:0060259)
0.0 0.0 GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.0 0.0 GO:0001543 ovarian follicle rupture(GO:0001543)
0.0 0.0 GO:0070527 platelet aggregation(GO:0070527)
0.0 0.0 GO:0030185 nitric oxide transport(GO:0030185)
0.0 0.1 GO:0043084 penile erection(GO:0043084)
0.0 0.0 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.0 0.2 GO:0030010 establishment of cell polarity(GO:0030010)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0030934 anchoring collagen complex(GO:0030934)
0.0 0.1 GO:0000445 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.0 0.1 GO:0031313 extrinsic component of vacuolar membrane(GO:0000306) extrinsic component of endosome membrane(GO:0031313)
0.0 0.1 GO:0070552 BRISC complex(GO:0070552)
0.0 0.0 GO:0042629 mast cell granule(GO:0042629)
0.0 0.0 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.1 GO:0002102 podosome(GO:0002102)
0.0 0.1 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.0 GO:0000942 condensed nuclear chromosome outer kinetochore(GO:0000942)
0.0 0.1 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.0 0.0 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.0 0.0 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.0 0.0 GO:0000778 condensed nuclear chromosome kinetochore(GO:0000778)
0.0 0.1 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.0 0.1 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 0.1 GO:0008278 cohesin complex(GO:0008278)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0019834 phospholipase A2 inhibitor activity(GO:0019834)
0.0 0.1 GO:0001159 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.0 0.1 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.0 0.1 GO:1901474 azole transporter activity(GO:0045118) azole transmembrane transporter activity(GO:1901474)
0.0 0.1 GO:0003829 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0003829)
0.0 0.1 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0 0.1 GO:0001758 retinal dehydrogenase activity(GO:0001758)
0.0 0.1 GO:0004528 phosphodiesterase I activity(GO:0004528)
0.0 0.0 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.0 0.1 GO:0016728 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.0 0.1 GO:0005010 insulin-like growth factor-activated receptor activity(GO:0005010)
0.0 0.1 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.0 0.1 GO:0031545 procollagen-proline 4-dioxygenase activity(GO:0004656) peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.0 0.1 GO:0016882 cyclo-ligase activity(GO:0016882)
0.0 0.1 GO:0004525 ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296)
0.0 0.1 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.0 0.2 GO:0019864 IgG binding(GO:0019864)
0.0 0.1 GO:0016842 amidine-lyase activity(GO:0016842)
0.0 0.1 GO:0008475 procollagen-lysine 5-dioxygenase activity(GO:0008475)
0.0 0.1 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.0 0.1 GO:0004597 peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.0 0.1 GO:0070696 transmembrane receptor protein serine/threonine kinase binding(GO:0070696)
0.0 0.1 GO:0048039 ubiquinone binding(GO:0048039)
0.0 0.1 GO:0070097 delta-catenin binding(GO:0070097)
0.0 0.0 GO:0004321 fatty-acyl-CoA synthase activity(GO:0004321)
0.0 0.0 GO:0000268 peroxisome targeting sequence binding(GO:0000268)
0.0 0.1 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) lysophosphatidic acid acyltransferase activity(GO:0042171) lysophospholipid acyltransferase activity(GO:0071617)
0.0 0.1 GO:0051637 obsolete Gram-positive bacterial cell surface binding(GO:0051637)
0.0 0.1 GO:0048495 Roundabout binding(GO:0048495)
0.0 0.1 GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.0 0.0 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.0 0.0 GO:0002060 purine nucleobase binding(GO:0002060)
0.0 0.3 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.0 0.0 GO:0004465 lipoprotein lipase activity(GO:0004465)
0.0 0.0 GO:0016635 oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor(GO:0016635)
0.0 0.1 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0 0.1 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.0 GO:0070324 thyroid hormone binding(GO:0070324)
0.0 0.1 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.0 0.0 GO:0004470 malic enzyme activity(GO:0004470)
0.0 0.1 GO:0008318 protein prenyltransferase activity(GO:0008318)
0.0 0.1 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.0 GO:0070492 oligosaccharide binding(GO:0070492)
0.0 0.1 GO:0019966 interleukin-1 binding(GO:0019966)
0.0 0.0 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.0 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.0 0.1 GO:0030492 hemoglobin binding(GO:0030492)
0.0 0.0 GO:0008061 chitin binding(GO:0008061)
0.0 0.0 GO:0042978 ornithine decarboxylase activator activity(GO:0042978)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.0 0.0 PID ERBB4 PATHWAY ErbB4 signaling events
0.0 0.0 PID GMCSF PATHWAY GMCSF-mediated signaling events
0.0 0.1 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
0.0 0.4 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.0 0.3 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.0 0.0 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.0 0.1 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.0 REACTOME SIGNALING BY THE B CELL RECEPTOR BCR Genes involved in Signaling by the B Cell Receptor (BCR)
0.0 0.0 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0 0.0 REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR Genes involved in Signaling by constitutively active EGFR
0.0 0.0 REACTOME TRANS GOLGI NETWORK VESICLE BUDDING Genes involved in trans-Golgi Network Vesicle Budding
0.0 0.3 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.1 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 0.1 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors