CREMA results: SOX14

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Transcription factors associated with SOX14

Gene Symbol	Gene ID	Gene Info
SOX14 Ensembl NCBI GeneCards UniProt	ENSG00000168875.1	SRY-box transcription factor 14

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

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CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
chr3_137483109_137483260	SOX14	395	0.920583	-0.48	1.9e-01	Click!
chr3_137486884_137487092	SOX14	3409	0.379818	-0.59	9.7e-02	Click!
chr3_137489858_137490009	SOX14	6354	0.326771	-0.43	2.4e-01	Click!
chr3_137490047_137490281	SOX14	6585	0.324979	0.58	9.8e-02	Click!
chr3_137490658_137490996	SOX14	7248	0.320540	-0.57	1.1e-01	Click!

Showing 1 to 5 of 5 entries

Activity of the SOX14 motif across conditions

Conditions sorted by the z-value of the SOX14 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

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Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr4_103967796_103967947	0.46	SLC9B2	solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2	11228	0.21
chr10_43648011_43648162	0.39	CSGALNACT2	chondroitin sulfate N-acetylgalactosaminyltransferase 2	14152	0.22
chr19_14486268_14486999	0.38	CD97	CD97 molecule	5335	0.16
chr5_145155108_145155259	0.37	PRELID2	PRELI domain containing 2	59665	0.15
chr2_3225421_3225572	0.36	TSSC1-IT1	TSSC1 intronic transcript 1 (non-protein coding)	79740	0.1
chr20_4795714_4796665	0.36	RASSF2	Ras association (RalGDS/AF-6) domain family member 2	420	0.85
chr2_145219103_145219318	0.35	ZEB2	zinc finger E-box binding homeobox 2	31073	0.22
chr4_79583519_79583729	0.34	ENSG00000238816	.	22370	0.19
chr3_134516445_134516596	0.33	EPHB1	EPH receptor B1	1537	0.41
chr10_97552518_97552961	0.33	ENTPD1	ectonucleoside triphosphate diphosphohydrolase 1	37025	0.15

Showing 1 to 10 of 200 entries

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of SOX14

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.6	GO:0033152	immunoglobulin V(D)J recombination(GO:0033152)
0.1	0.3	GO:0051788	response to misfolded protein(GO:0051788)
0.0	0.3	GO:0001755	neural crest cell migration(GO:0001755)
0.1	0.2	GO:0046471	phosphatidylglycerol biosynthetic process(GO:0006655) cardiolipin metabolic process(GO:0032048) cardiolipin biosynthetic process(GO:0032049) phosphatidylglycerol metabolic process(GO:0046471)
0.1	0.2	GO:0060242	contact inhibition(GO:0060242)
0.1	0.2	GO:0007343	egg activation(GO:0007343)
0.1	0.2	GO:0070050	neuron cellular homeostasis(GO:0070050)
0.1	0.2	GO:0021859	pyramidal neuron differentiation(GO:0021859) pyramidal neuron development(GO:0021860)
0.0	0.2	GO:0021631	optic nerve morphogenesis(GO:0021631)
0.0	0.2	GO:0070570	regulation of axon regeneration(GO:0048679) regulation of neuron projection regeneration(GO:0070570)

Showing 1 to 10 of 106 entries

Gene overrepresentation in cellular component category:

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Total log-likelihood	Term	Description
0.2	GO:0034366	spherical high-density lipoprotein particle(GO:0034366)
0.2	GO:0005697	telomerase holoenzyme complex(GO:0005697)
0.2	GO:0005844	polysome(GO:0005844)
0.1	GO:0033270	paranode region of axon(GO:0033270)
0.1	GO:0033268	node of Ranvier(GO:0033268)
0.1	GO:0032444	activin responsive factor complex(GO:0032444)
0.1	GO:0043259	laminin-10 complex(GO:0043259)
0.1	GO:0005958	DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958)
0.1	GO:0048179	activin receptor complex(GO:0048179)
0.1	GO:0005662	DNA replication factor A complex(GO:0005662)

Showing 1 to 10 of 20 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.4	GO:0017022	myosin binding(GO:0017022)
0.0	0.4	GO:0045028	G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.1	0.2	GO:0031957	very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.1	0.2	GO:0070053	thrombospondin receptor activity(GO:0070053)
0.0	0.2	GO:0042285	UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285)
0.0	0.2	GO:0070097	delta-catenin binding(GO:0070097)
0.0	0.2	GO:0004691	cAMP-dependent protein kinase activity(GO:0004691)
0.0	0.2	GO:0019864	IgG binding(GO:0019864)
0.0	0.2	GO:0051787	misfolded protein binding(GO:0051787)
0.1	0.1	GO:0003829	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0003829)

Showing 1 to 10 of 68 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.2	PID ALK2 PATHWAY	ALK2 signaling events

Showing 1 to 1 of 1 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Total log-likelihood	Term	Description
0.4	REACTOME GPVI MEDIATED ACTIVATION CASCADE	Genes involved in GPVI-mediated activation cascade
0.3	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.2	REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.2	REACTOME SYNTHESIS OF PC	Genes involved in Synthesis of PC
0.1	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.1	REACTOME P2Y RECEPTORS	Genes involved in P2Y receptors
0.1	REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE	Genes involved in Reversible Hydration of Carbon Dioxide
0.1	REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR	Genes involved in Trafficking and processing of endosomal TLR
0.1	REACTOME HYALURONAN METABOLISM	Genes involved in Hyaluronan metabolism
0.0	REACTOME PLATELET CALCIUM HOMEOSTASIS	Genes involved in Platelet calcium homeostasis

Showing 1 to 10 of 11 entries

Results for SOX14

Z-value: 1.22

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Transcription factors associated with SOX14

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Activity of the SOX14 motif across conditions

Conditions sorted by the z-value of the SOX14 motif activity

Top target CREs of the motif:

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of SOX14

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: