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ENCODE: H3K4me1 ChIP-Seq of primary human cells

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for SOX14

Z-value: 1.22

Motif logo

Transcription factors associated with SOX14

Gene Symbol	Gene ID	Gene Info
SOX14 Ensembl NCBI GeneCards UniProt	ENSG00000168875.1	SOX14

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
SOX14	chr3_137486884_137487092	3409	0.379818	-0.59	9.7e-02	Click!
SOX14	chr3_137490047_137490281	6585	0.324979	0.58	9.8e-02	Click!
SOX14	chr3_137490658_137490996	7248	0.320540	-0.57	1.1e-01	Click!
SOX14	chr3_137483109_137483260	395	0.920583	-0.48	1.9e-01	Click!
SOX14	chr3_137489858_137490009	6354	0.326771	-0.43	2.4e-01	Click!

Activity of the SOX14 motif across conditions

Conditions sorted by the z-value of the SOX14 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr4_103967796_103967947	0.46	SLC9B2	solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2	11228	0.21
chr10_43648011_43648162	0.39	CSGALNACT2	chondroitin sulfate N-acetylgalactosaminyltransferase 2	14152	0.22
chr19_14486268_14486999	0.38	CD97	CD97 molecule	5335	0.16
chr5_145155108_145155259	0.37	PRELID2	PRELI domain containing 2	59665	0.15
chr2_3225421_3225572	0.36	TSSC1-IT1	TSSC1 intronic transcript 1 (non-protein coding)	79740	0.1
chr20_4795714_4796665	0.36	RASSF2	Ras association (RalGDS/AF-6) domain family member 2	420	0.85
chr2_145219103_145219318	0.35	ZEB2	zinc finger E-box binding homeobox 2	31073	0.22
chr4_79583519_79583729	0.34	ENSG00000238816	.	22370	0.19
chr3_134516445_134516596	0.33	EPHB1	EPH receptor B1	1537	0.41
chr10_97552518_97552961	0.33	ENTPD1	ectonucleoside triphosphate diphosphohydrolase 1	37025	0.15
chr1_36173339_36173885	0.32	ENSG00000239859	.	1737	0.31
chr16_56999551_56999979	0.31	CETP	cholesteryl ester transfer protein, plasma	3746	0.14
chr3_148674000_148674298	0.31	RP11-680B3.2		3750	0.26
chrX_77173850_77174555	0.31	ATP7A	ATPase, Cu++ transporting, alpha polypeptide	8003	0.16
chr10_44312151_44312815	0.31	ZNF32	zinc finger protein 32	168179	0.03
chr8_10128293_10128444	0.30	MSRA	methionine sulfoxide reductase A	30677	0.22
chr1_61598374_61598525	0.28	RP4-802A10.1		8044	0.25
chr1_66837902_66838308	0.28	PDE4B	phosphodiesterase 4B, cAMP-specific	18040	0.28
chr9_131007648_131008173	0.28	ENSG00000264823	.	601	0.42
chr15_70196429_70196590	0.27	ENSG00000215958	.	118666	0.06
chr14_22926253_22926566	0.26	TRDD3	T cell receptor delta diversity 3	8304	0.11
chr5_17441932_17442083	0.26	ENSG00000201715	.	96282	0.09
chr11_47949983_47950362	0.26	PTPRJ	protein tyrosine phosphatase, receptor type, J	51941	0.12
chr10_64378374_64378669	0.26	ZNF365	zinc finger protein 365	25012	0.22
chr10_7991050_7991201	0.26	GATA3	GATA binding protein 3	105531	0.07
chr11_1145070_1145742	0.26	MUC5AC	mucin 5AC, oligomeric mucus/gel-forming	6174	0.2
chr18_46242484_46242870	0.25	RP11-426J5.2		27887	0.2
chr19_17610867_17611300	0.25	SLC27A1	solute carrier family 27 (fatty acid transporter), member 1	92	0.93
chr19_50009932_50010143	0.25	FCGRT	Fc fragment of IgG, receptor, transporter, alpha	5499	0.06
chr3_11494368_11494519	0.25	ATG7	autophagy related 7	88310	0.09
chr5_43674374_43674666	0.25	NNT	nicotinamide nucleotide transhydrogenase	29061	0.2
chr5_156955806_156956039	0.25	ADAM19	ADAM metallopeptidase domain 19	26092	0.14
chr3_66330359_66330510	0.25	ENSG00000206759	.	13210	0.22
chr10_30789869_30790276	0.25	ENSG00000239744	.	54761	0.13
chr8_21542340_21542522	0.25	GFRA2	GDNF family receptor alpha 2	103404	0.07
chr1_201574377_201574631	0.24	AC096677.1	Uncharacterized protein ENSP00000471857	17509	0.16
chr1_54830860_54831046	0.24	SSBP3	single stranded DNA binding protein 3	40224	0.15
chr11_48057199_48057485	0.24	AC103828.1		19935	0.19
chrX_19705406_19705851	0.24	SH3KBP1	SH3-domain kinase binding protein 1	16512	0.28
chr4_54633852_54634003	0.23	LNX1	ligand of numb-protein X 1, E3 ubiquitin protein ligase	66355	0.12
chr2_161235850_161236019	0.23	ENSG00000252465	.	17545	0.2
chr5_64485748_64485899	0.23	ENSG00000207439	.	66627	0.14
chr3_132956077_132956228	0.23	RP11-402L6.1		19740	0.23
chr2_64328647_64328937	0.23	AC074289.1		41581	0.16
chr8_98272161_98272312	0.23	TSPYL5	TSPY-like 5	17940	0.25
chr10_31986594_31986822	0.23	ENSG00000222412	.	58356	0.16
chr3_107697056_107697238	0.23	CD47	CD47 molecule	80061	0.11
chr5_94926047_94926198	0.23	GPR150	G protein-coupled receptor 150	29660	0.13
chr1_117036571_117036783	0.22	ENSG00000200547	.	41519	0.12
chr19_51670246_51671430	0.22	SIGLEC17P	sialic acid binding Ig-like lectin 17, pseudogene	184	0.89
chr2_121360012_121360163	0.22	ENSG00000201006	.	48762	0.18
chr1_97899901_97900052	0.22	DPYD-IT1	DPYD intronic transcript 1 (non-protein coding)	14279	0.31
chr11_67057839_67058573	0.22	ANKRD13D	ankyrin repeat domain 13 family, member D	1333	0.3
chr8_61454233_61454384	0.22	RP11-91I20.4		11287	0.22
chr7_47547067_47547313	0.22	TNS3	tensin 3	26307	0.26
chr14_79073358_79073509	0.22	NRXN3	neurexin 3	7842	0.22
chr1_183001256_183001465	0.22	LAMC1	laminin, gamma 1 (formerly LAMB2)	8765	0.21
chr4_55808155_55808468	0.22	ENSG00000264332	.	68788	0.11
chr13_100027297_100027717	0.21	ENSG00000207719	.	19122	0.2
chr18_53868353_53868679	0.21	ENSG00000201816	.	121691	0.07
chr11_128607706_128608101	0.21	FLI1	Fli-1 proto-oncogene, ETS transcription factor	26782	0.17
chr3_129311849_129312381	0.21	ENSG00000239437	.	1923	0.28
chr6_20484087_20484358	0.21	ENSG00000201683	.	16184	0.16
chr18_22811436_22811645	0.21	ZNF521	zinc finger protein 521	46	0.99
chr2_102049705_102049856	0.21	RFX8	RFX family member 8, lacking RFX DNA binding domain	40957	0.16
chr2_38010215_38010366	0.21	CDC42EP3	CDC42 effector protein (Rho GTPase binding) 3	44679	0.19
chr13_32059321_32059637	0.21	RXFP2	relaxin/insulin-like family peptide receptor 2	254195	0.02
chrX_153947159_153947493	0.20	GAB3	GRB2-associated binding protein 3	32006	0.1
chr8_130602358_130602703	0.20	ENSG00000266387	.	92617	0.06
chr8_142424232_142425134	0.20	PTP4A3	protein tyrosine phosphatase type IVA, member 3	7324	0.13
chr6_47492501_47492652	0.20	ENSG00000199762	.	35773	0.16
chr6_5985144_5985295	0.20	NRN1	neuritin 1	21981	0.22
chr17_27071776_27071993	0.20	TRAF4	TNF receptor-associated factor 4	781	0.27
chr1_59622775_59622926	0.20	FGGY	FGGY carbohydrate kinase domain containing	139460	0.05
chr6_3869542_3869744	0.20	FAM50B	family with sequence similarity 50, member B	20021	0.19
chr5_126146602_126147018	0.20	LMNB1	lamin B1	33929	0.19
chr4_111987974_111988125	0.20	ENSG00000215961	.	206246	0.03
chr22_18903424_18903575	0.20	DGCR6	DiGeorge syndrome critical region gene 6	9633	0.17
chr17_27072175_27072438	0.20	TRAF4	TNF receptor-associated factor 4	1203	0.16
chr15_29106368_29106519	0.20	GOLGA6L7P	golgin A6 family-like 7, pseudogene	12715	0.18
chr16_48595927_48596078	0.20	RP11-44I10.3		2430	0.3
chr1_204446570_204446721	0.20	PIK3C2B	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta	10171	0.19
chr13_32622361_32622649	0.20	FRY	furry homolog (Drosophila)	12496	0.23
chr8_132854804_132854955	0.20	EFR3A	EFR3 homolog A (S. cerevisiae)	61456	0.16
chr3_16340065_16340275	0.20	RP11-415F23.2		15776	0.16
chr9_38084332_38084615	0.20	SHB	Src homology 2 domain containing adaptor protein B	15263	0.24
chr8_105350987_105351434	0.20	DCSTAMP	dendrocyte expressed seven transmembrane protein	844	0.68
chr2_42425739_42426081	0.20	AC083949.1		28469	0.19
chr3_187989530_187989681	0.20	LPP	LIM domain containing preferred translocation partner in lipoma	31953	0.22
chr1_64553029_64553180	0.19	ENSG00000200508	.	20691	0.17
chr6_167383774_167384203	0.19	RNASET2	ribonuclease T2	13316	0.13
chrX_135836171_135836490	0.19	ARHGEF6	Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6	13172	0.18
chr5_157940155_157940453	0.19	CTD-2363C16.1		469710	0.01
chr18_46585815_46585966	0.19	ENSG00000263849	.	9752	0.19
chr10_63554784_63554935	0.19	ARID5B	AT rich interactive domain 5B (MRF1-like)	106200	0.07
chr19_13320112_13320432	0.19	CACNA1A	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	47942	0.08
chr8_61925745_61925971	0.19	CLVS1	clavesin 1	43859	0.2
chr1_65522143_65522294	0.19	ENSG00000265996	.	1307	0.39
chr17_9160012_9160446	0.19	RP11-85B7.4		26262	0.21
chr10_75563756_75563907	0.19	NDST2	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2	729	0.41
chr18_65598176_65598327	0.19	DSEL	dermatan sulfate epimerase-like	414034	0.01
chr12_120120626_120120777	0.19	PRKAB1	protein kinase, AMP-activated, beta 1 non-catalytic subunit	10652	0.16
chr11_121963982_121964133	0.19	ENSG00000207971	.	6495	0.17
chr8_27468856_27469025	0.19	CLU	clusterin	8	0.98
chr11_48030445_48030685	0.18	AC103828.1		6842	0.22
chr8_102505453_102505604	0.18	GRHL2	grainyhead-like 2 (Drosophila)	542	0.6
chr1_240397636_240397787	0.18	FMN2	formin 2	10849	0.24
chr1_206755327_206755741	0.18	RASSF5	Ras association (RalGDS/AF-6) domain family member 5	25041	0.13
chr19_1651787_1652144	0.18	TCF3	transcription factor 3	361	0.81
chr2_107576982_107577133	0.18	ST6GAL2	ST6 beta-galactosamide alpha-2,6-sialyltranferase 2	73493	0.12
chr10_79287048_79287199	0.18	ENSG00000199592	.	59684	0.14
chr9_120481193_120481344	0.18	ENSG00000201444	.	10888	0.2
chr17_17753098_17753798	0.18	TOM1L2	target of myb1-like 2 (chicken)	12646	0.14
chr7_27964371_27964522	0.18	ENSG00000265382	.	44340	0.16
chr11_48088655_48089020	0.18	ENSG00000263693	.	29497	0.17
chr5_61880973_61881321	0.18	LRRC70	leucine rich repeat containing 70	6445	0.23
chr13_75343971_75344251	0.18	ENSG00000206812	.	339613	0.01
chr10_105152344_105152495	0.18	ENSG00000221767	.	1739	0.21
chr14_69551433_69551584	0.18	ENSG00000206768	.	59162	0.11
chr11_111658887_111659109	0.18	PPP2R1B	protein phosphatase 2, regulatory subunit A, beta	21847	0.14
chr7_37429018_37429454	0.17	ENSG00000200113	.	29995	0.15
chr1_56602778_56602929	0.17	PIGQP1	phosphatidylinositol glycan anchor biosynthesis, class Q pseudogene 1	197900	0.03
chr2_69054034_69054428	0.17	AC097495.2		4945	0.22
chrX_109937306_109937457	0.17	CHRDL1	chordin-like 1	101612	0.08
chr10_6237578_6237796	0.17	RP11-414H17.5		6969	0.16
chr1_28222979_28223130	0.17	RPA2	replication protein A2, 32kDa	542	0.67
chr8_85094524_85094675	0.17	RALYL	RALY RNA binding protein-like	423	0.91
chr2_8534562_8534786	0.17	AC011747.7		281222	0.01
chr9_79207509_79207915	0.17	ENSG00000241781	.	20981	0.22
chr11_47989764_47989999	0.17	PTPRJ	protein tyrosine phosphatase, receptor type, J	12232	0.21
chr9_100199219_100199370	0.17	TDRD7	tudor domain containing 7	24918	0.19
chr19_19562771_19562932	0.17	GATAD2A	GATA zinc finger domain containing 2A	5070	0.15
chr16_72821877_72822476	0.17	ENSG00000265573	.	504	0.64
chr3_112391920_112392214	0.17	CCDC80	coiled-coil domain containing 80	31920	0.2
chr7_45233024_45233175	0.17	RAMP3	receptor (G protein-coupled) activity modifying protein 3	35671	0.15
chr21_46471417_46471568	0.17	AP001579.1	Uncharacterized protein	21435	0.14
chr11_124708975_124709188	0.17	ENSG00000215942	.	3962	0.14
chr1_183086575_183086726	0.17	LAMC1	laminin, gamma 1 (formerly LAMB2)	20971	0.18
chr6_84992412_84992563	0.17	KIAA1009	KIAA1009	55134	0.18
chr5_14144482_14144849	0.17	TRIO	trio Rho guanine nucleotide exchange factor	836	0.77
chr6_72129760_72130197	0.17	ENSG00000207827	.	16654	0.22
chr12_93797733_93797884	0.17	NUDT4	nudix (nucleoside diphosphate linked moiety X)-type motif 4	25378	0.13
chr2_145269557_145269741	0.17	ZEB2	zinc finger E-box binding homeobox 2	5466	0.26
chr7_75955987_75956138	0.17	HSPB1	heat shock 27kDa protein 1	23168	0.13
chr2_64969896_64970153	0.17	ENSG00000253082	.	33214	0.17
chr9_80635533_80635684	0.17	GNAQ	guanine nucleotide binding protein (G protein), q polypeptide	9912	0.31
chr17_56232433_56232668	0.17	OR4D1	olfactory receptor, family 4, subfamily D, member 1	56	0.97
chr3_47844781_47845806	0.17	DHX30	DEAH (Asp-Glu-Ala-His) box helicase 30	638	0.69
chr17_6657101_6657320	0.17	XAF1	XIAP associated factor 1	1674	0.3
chr11_96024786_96024937	0.17	ENSG00000266192	.	49741	0.14
chr13_30389980_30390131	0.17	UBL3	ubiquitin-like 3	34766	0.23
chr1_10182603_10182825	0.16	UBE4B	ubiquitination factor E4B	614	0.74
chrX_19620903_19621086	0.16	SH3KBP1	SH3-domain kinase binding protein 1	67486	0.13
chr3_194277464_194277768	0.16	ENSG00000252053	.	23304	0.12
chr6_49397963_49398114	0.16	MUT	methylmalonyl CoA mutase	32866	0.16
chr10_114863343_114863771	0.16	TCF7L2	transcription factor 7-like 2 (T-cell specific, HMG-box)	40122	0.21
chr20_47339217_47339820	0.16	ENSG00000251876	.	16467	0.27
chr4_113263286_113263437	0.16	ALPK1	alpha-kinase 1	44825	0.13
chr13_78406581_78406732	0.16	EDNRB	endothelin receptor type B	86289	0.08
chr6_56390814_56390965	0.16	DST	dystonin	52101	0.16
chrX_67905613_67905964	0.16	STARD8	StAR-related lipid transfer (START) domain containing 8	7705	0.31
chr5_72634397_72634548	0.16	FOXD1	forkhead box D1	109880	0.06
chr12_57947057_57947208	0.16	KIF5A	kinesin family member 5A	3305	0.1
chr10_120873283_120874145	0.16	FAM45A	family with sequence similarity 45, member A	10085	0.14
chr19_10097648_10097799	0.16	CTD-2553C6.1		8950	0.11
chr12_11864478_11864709	0.16	ETV6	ets variant 6	40842	0.2
chr9_136710943_136711094	0.16	SARDH	sarcosine dehydrogenase	105941	0.06
chr8_37132456_37132991	0.16	RP11-150O12.6		241816	0.02
chr6_107979051_107979415	0.16	SCML4	sex comb on midleg-like 4 (Drosophila)	74366	0.11
chr6_90963667_90963818	0.16	BACH2	BTB and CNC homology 1, basic leucine zipper transcription factor 2	42719	0.18
chr11_19799330_19799633	0.16	NAV2	neuron navigator 2	9	0.98
chr15_88415316_88415597	0.16	NTRK3	neurotrophic tyrosine kinase, receptor, type 3	60865	0.16
chr7_155251375_155251945	0.16	EN2	engrailed homeobox 2	836	0.63
chrX_65244659_65244810	0.16	ENSG00000207939	.	6022	0.22
chrX_77423682_77423833	0.16	TAF9B	TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa	28554	0.22
chr21_35135967_35136118	0.16	ITSN1	intersectin 1 (SH3 domain protein)	28696	0.19
chr7_128716222_128716373	0.16	ENSG00000238733	.	14712	0.16
chrX_77193735_77193886	0.16	ATP7A	ATPase, Cu++ transporting, alpha polypeptide	27611	0.14
chr1_109261913_109262064	0.16	FNDC7	fibronectin type III domain containing 7	3045	0.21
chr5_34718601_34718752	0.16	RAI14	retinoic acid induced 14	31012	0.19
chr5_88175476_88175627	0.16	MEF2C	myocyte enhancer factor 2C	1757	0.41
chr4_103433017_103433168	0.16	NFKB1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	8560	0.21
chr7_141998755_141998906	0.16	PRSS3P3	protease, serine, 3 pseudogene 3	9221	0.22
chrX_153401312_153401677	0.16	OPN1LW	opsin 1 (cone pigments), long-wave-sensitive	8204	0.13
chr6_26479269_26479651	0.16	BTN2A1	butyrophilin, subfamily 2, member A1	14005	0.12
chr12_65044536_65044708	0.16	RP11-338E21.3		4177	0.16
chr12_114371307_114371458	0.15	RP11-780K2.1		1008	0.65
chr2_209133854_209134145	0.15	PIKFYVE	phosphoinositide kinase, FYVE finger containing	2912	0.19
chr5_115844005_115844156	0.15	SEMA6A	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A	28044	0.22
chr2_48559099_48559360	0.15	ENSG00000251889	.	8736	0.22
chrX_117646925_117647156	0.15	DOCK11	dedicator of cytokinesis 11	17168	0.23
chr11_12150023_12150174	0.15	MICAL2	microtubule associated monooxygenase, calponin and LIM domain containing 2	7076	0.29
chr10_29975293_29975444	0.15	ENSG00000222092	.	25476	0.2
chr18_56554770_56555263	0.15	ZNF532	zinc finger protein 532	22230	0.17
chr3_168599289_168599440	0.15	MECOM	MDS1 and EVI1 complex locus	246458	0.02
chr10_81134576_81134901	0.15	RP11-342M3.5		7346	0.21
chr9_92040656_92041457	0.15	SEMA4D	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D	7308	0.26
chr5_130728834_130729229	0.15	CDC42SE2	CDC42 small effector 2	7732	0.31
chr4_143260601_143260752	0.15	INPP4B	inositol polyphosphate-4-phosphatase, type II, 105kDa	33579	0.26
chrX_10911310_10911578	0.15	MID1	midline 1 (Opitz/BBB syndrome)	59671	0.16

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of SOX14

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View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.6	GO:0033152	immunoglobulin V(D)J recombination(GO:0033152)
0.1	0.2	GO:0046471	phosphatidylglycerol biosynthetic process(GO:0006655) cardiolipin metabolic process(GO:0032048) cardiolipin biosynthetic process(GO:0032049) phosphatidylglycerol metabolic process(GO:0046471)
0.1	0.2	GO:0060242	contact inhibition(GO:0060242)
0.1	0.2	GO:0007343	egg activation(GO:0007343)
0.1	0.2	GO:0070050	neuron cellular homeostasis(GO:0070050)
0.1	0.3	GO:0051788	response to misfolded protein(GO:0051788)
0.1	0.2	GO:0021859	pyramidal neuron differentiation(GO:0021859) pyramidal neuron development(GO:0021860)
0.0	0.1	GO:0019276	UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.0	0.1	GO:0042996	regulation of Golgi to plasma membrane protein transport(GO:0042996)
0.0	0.2	GO:0021631	optic nerve morphogenesis(GO:0021631)
0.0	0.1	GO:0051305	chromosome movement towards spindle pole(GO:0051305)
0.0	0.2	GO:0070570	regulation of axon regeneration(GO:0048679) regulation of neuron projection regeneration(GO:0070570)
0.0	0.1	GO:1900115	sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.0	0.1	GO:0010957	negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137)
0.0	0.1	GO:0051497	negative regulation of stress fiber assembly(GO:0051497)
0.0	0.1	GO:0035405	histone-threonine phosphorylation(GO:0035405)
0.0	0.2	GO:0007185	transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0	0.0	GO:0060028	convergent extension involved in axis elongation(GO:0060028)
0.0	0.1	GO:0010572	positive regulation of platelet activation(GO:0010572)
0.0	0.1	GO:0045003	DNA recombinase assembly(GO:0000730) double-strand break repair via synthesis-dependent strand annealing(GO:0045003)
0.0	0.1	GO:0010447	response to acidic pH(GO:0010447)
0.0	0.1	GO:0090073	positive regulation of protein homodimerization activity(GO:0090073)
0.0	0.1	GO:0048934	peripheral nervous system neuron differentiation(GO:0048934)
0.0	0.1	GO:0009221	pyrimidine deoxyribonucleotide biosynthetic process(GO:0009221)
0.0	0.2	GO:1901532	regulation of megakaryocyte differentiation(GO:0045652) regulation of hematopoietic progenitor cell differentiation(GO:1901532)
0.0	0.1	GO:0048859	formation of anatomical boundary(GO:0048859)
0.0	0.1	GO:0007442	hindgut morphogenesis(GO:0007442) hindgut development(GO:0061525)
0.0	0.1	GO:0071480	cellular response to gamma radiation(GO:0071480)
0.0	0.1	GO:0008356	asymmetric cell division(GO:0008356)
0.0	0.1	GO:0001543	ovarian follicle rupture(GO:0001543)
0.0	0.1	GO:0009649	entrainment of circadian clock(GO:0009649)
0.0	0.0	GO:0009189	deoxyribonucleoside diphosphate biosynthetic process(GO:0009189)
0.0	0.1	GO:0045163	clustering of voltage-gated potassium channels(GO:0045163)
0.0	0.1	GO:0060054	positive regulation of epithelial cell proliferation involved in wound healing(GO:0060054)
0.0	0.1	GO:0060997	dendritic spine morphogenesis(GO:0060997) regulation of dendritic spine morphogenesis(GO:0061001) dendritic spine organization(GO:0097061)
0.0	0.1	GO:0017183	peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.0	0.0	GO:0001955	blood vessel maturation(GO:0001955)
0.0	0.1	GO:0006853	carnitine shuttle(GO:0006853) carnitine transmembrane transport(GO:1902603)
0.0	0.1	GO:0048312	intracellular distribution of mitochondria(GO:0048312)
0.0	0.0	GO:0009138	pyrimidine nucleoside diphosphate metabolic process(GO:0009138)
0.0	0.1	GO:2000846	corticosteroid hormone secretion(GO:0035930) regulation of steroid hormone secretion(GO:2000831) regulation of corticosteroid hormone secretion(GO:2000846)
0.0	0.1	GO:0016266	O-glycan processing(GO:0016266)
0.0	0.1	GO:0030223	neutrophil differentiation(GO:0030223)
0.0	0.1	GO:0002032	desensitization of G-protein coupled receptor protein signaling pathway by arrestin(GO:0002032)
0.0	0.1	GO:0009405	pathogenesis(GO:0009405)
0.0	0.1	GO:1901341	activation of store-operated calcium channel activity(GO:0032237) regulation of store-operated calcium channel activity(GO:1901339) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0	0.1	GO:0071731	response to nitric oxide(GO:0071731)
0.0	0.1	GO:0015889	cobalamin transport(GO:0015889)
0.0	0.0	GO:0042789	mRNA transcription from RNA polymerase II promoter(GO:0042789)
0.0	0.0	GO:0002019	regulation of renal output by angiotensin(GO:0002019)
0.0	0.1	GO:0034446	substrate adhesion-dependent cell spreading(GO:0034446)
0.0	0.1	GO:0045663	positive regulation of myoblast differentiation(GO:0045663)
0.0	0.1	GO:0070208	protein heterotrimerization(GO:0070208)
0.0	0.1	GO:0003402	planar cell polarity pathway involved in axis elongation(GO:0003402)
0.0	0.0	GO:0000491	small nucleolar ribonucleoprotein complex assembly(GO:0000491) box C/D snoRNP assembly(GO:0000492)
0.0	0.0	GO:0002043	blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.0	0.0	GO:0033147	negative regulation of intracellular estrogen receptor signaling pathway(GO:0033147)
0.0	0.1	GO:0031641	regulation of myelination(GO:0031641)
0.0	0.0	GO:0002326	B cell lineage commitment(GO:0002326)
0.0	0.0	GO:0043162	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.0	0.3	GO:0001755	neural crest cell migration(GO:0001755)
0.0	0.1	GO:0043615	astrocyte cell migration(GO:0043615)
0.0	0.0	GO:0048304	positive regulation of isotype switching to IgG isotypes(GO:0048304)
0.0	0.1	GO:0007023	post-chaperonin tubulin folding pathway(GO:0007023)
0.0	0.1	GO:0018345	protein palmitoylation(GO:0018345)
0.0	0.0	GO:0030644	cellular chloride ion homeostasis(GO:0030644) chloride ion homeostasis(GO:0055064)
0.0	0.0	GO:0051152	positive regulation of smooth muscle cell differentiation(GO:0051152)
0.0	0.1	GO:0007097	nuclear migration(GO:0007097)
0.0	0.1	GO:0046642	negative regulation of alpha-beta T cell proliferation(GO:0046642)
0.0	0.0	GO:0046877	regulation of saliva secretion(GO:0046877)
0.0	0.0	GO:0060523	prostate epithelial cord elongation(GO:0060523)
0.0	0.0	GO:0030948	negative regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030948)
0.0	0.0	GO:0010766	negative regulation of sodium ion transport(GO:0010766)
0.0	0.1	GO:0008653	lipopolysaccharide metabolic process(GO:0008653)
0.0	0.0	GO:0045636	positive regulation of melanocyte differentiation(GO:0045636) positive regulation of pigment cell differentiation(GO:0050942)
0.0	0.1	GO:0007549	dosage compensation(GO:0007549)
0.0	0.0	GO:0002328	pro-B cell differentiation(GO:0002328)
0.0	0.1	GO:0032493	response to bacterial lipoprotein(GO:0032493) response to bacterial lipopeptide(GO:0070339) cellular response to bacterial lipoprotein(GO:0071220) cellular response to bacterial lipopeptide(GO:0071221)
0.0	0.1	GO:0070265	necrotic cell death(GO:0070265)
0.0	0.0	GO:0001705	ectoderm formation(GO:0001705)
0.0	0.0	GO:0030505	inorganic diphosphate transport(GO:0030505)
0.0	0.1	GO:0045359	interferon-beta biosynthetic process(GO:0045350) regulation of interferon-beta biosynthetic process(GO:0045357) positive regulation of interferon-beta biosynthetic process(GO:0045359)
0.0	0.0	GO:0032682	negative regulation of chemokine production(GO:0032682) negative regulation of chemokine biosynthetic process(GO:0045079)
0.0	0.0	GO:0072577	endothelial cell apoptotic process(GO:0072577) epithelial cell apoptotic process(GO:1904019) regulation of epithelial cell apoptotic process(GO:1904035) regulation of endothelial cell apoptotic process(GO:2000351)
0.0	0.1	GO:0044341	sodium-dependent phosphate transport(GO:0044341)
0.0	0.0	GO:0072217	negative regulation of metanephros development(GO:0072217)
0.0	0.0	GO:0030854	positive regulation of granulocyte differentiation(GO:0030854)
0.0	0.0	GO:0006189	'de novo' IMP biosynthetic process(GO:0006189)
0.0	0.1	GO:0002063	chondrocyte development(GO:0002063)
0.0	0.0	GO:0042726	flavin-containing compound metabolic process(GO:0042726)
0.0	0.1	GO:0006303	double-strand break repair via nonhomologous end joining(GO:0006303)
0.0	0.0	GO:0070498	interleukin-1-mediated signaling pathway(GO:0070498)
0.0	0.1	GO:1901797	negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518) negative regulation of signal transduction by p53 class mediator(GO:1901797)
0.0	0.1	GO:0060391	positive regulation of SMAD protein import into nucleus(GO:0060391)
0.0	0.1	GO:0046487	glyoxylate metabolic process(GO:0046487)
0.0	0.0	GO:0032878	regulation of establishment or maintenance of cell polarity(GO:0032878)
0.0	0.0	GO:0048245	eosinophil chemotaxis(GO:0048245) eosinophil migration(GO:0072677)
0.0	0.1	GO:0060710	chorio-allantoic fusion(GO:0060710)
0.0	0.0	GO:0030538	embryonic genitalia morphogenesis(GO:0030538)
0.0	0.1	GO:0050775	positive regulation of dendrite morphogenesis(GO:0050775)
0.0	0.0	GO:0060737	prostate gland morphogenetic growth(GO:0060737)
0.0	0.0	GO:0006681	galactosylceramide metabolic process(GO:0006681)
0.0	0.0	GO:0051103	DNA ligation involved in DNA repair(GO:0051103)
0.0	0.0	GO:0006927	obsolete transformed cell apoptotic process(GO:0006927)
0.0	0.1	GO:1903672	positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050) positive regulation of sprouting angiogenesis(GO:1903672)
0.0	0.0	GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway(GO:0010803)

Gene overrepresentation in cellular component category:

Total log-likelihood	Term	Description
0.1	GO:0033270	paranode region of axon(GO:0033270)
0.1	GO:0033268	node of Ranvier(GO:0033268)
0.1	GO:0032444	activin responsive factor complex(GO:0032444)
0.2	GO:0034366	spherical high-density lipoprotein particle(GO:0034366)
0.2	GO:0005697	telomerase holoenzyme complex(GO:0005697)
0.1	GO:0043259	laminin-10 complex(GO:0043259)
0.1	GO:0005958	DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958)
0.1	GO:0048179	activin receptor complex(GO:0048179)
0.0	GO:0005896	interleukin-6 receptor complex(GO:0005896)
0.1	GO:0005662	DNA replication factor A complex(GO:0005662)
0.0	GO:0032809	neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0	GO:0009331	glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.0	GO:0045323	interleukin-1 receptor complex(GO:0045323)
0.1	GO:0042582	primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.2	GO:0005844	polysome(GO:0005844)
0.0	GO:0005588	collagen type V trimer(GO:0005588)
0.1	GO:0042599	lamellar body(GO:0042599)
0.1	GO:0031588	nucleotide-activated protein kinase complex(GO:0031588)
0.0	GO:0005900	oncostatin-M receptor complex(GO:0005900)
0.1	GO:0001527	microfibril(GO:0001527)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0031957	very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.1	0.2	GO:0070053	thrombospondin receptor activity(GO:0070053)
0.1	0.1	GO:0003829	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0003829)
0.0	0.2	GO:0042285	UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285)
0.0	0.1	GO:0070644	vitamin D response element binding(GO:0070644)
0.0	0.1	GO:0004677	DNA-dependent protein kinase activity(GO:0004677)
0.0	0.2	GO:0070097	delta-catenin binding(GO:0070097)
0.0	0.1	GO:0016531	copper chaperone activity(GO:0016531)
0.0	0.1	GO:0050501	hyaluronan synthase activity(GO:0050501)
0.0	0.1	GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.0	0.2	GO:0004691	cAMP-dependent protein kinase activity(GO:0004691)
0.0	0.1	GO:0016309	1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0	0.1	GO:0035184	histone threonine kinase activity(GO:0035184)
0.0	0.1	GO:0016416	carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.0	0.1	GO:0008109	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0	0.1	GO:0005042	netrin receptor activity(GO:0005042)
0.0	0.0	GO:0005127	ciliary neurotrophic factor receptor binding(GO:0005127)
0.0	0.0	GO:0016530	metallochaperone activity(GO:0016530)
0.0	0.0	GO:0004340	glucokinase activity(GO:0004340)
0.0	0.1	GO:0008046	axon guidance receptor activity(GO:0008046)
0.0	0.2	GO:0019864	IgG binding(GO:0019864)
0.0	0.1	GO:0016774	phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.0	0.1	GO:0016361	activin receptor activity, type I(GO:0016361)
0.0	0.1	GO:0005315	inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0	0.2	GO:0051787	misfolded protein binding(GO:0051787)
0.0	0.1	GO:0047238	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.0	0.1	GO:0047623	AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0	0.1	GO:0048020	CCR chemokine receptor binding(GO:0048020)
0.0	0.1	GO:0004465	lipoprotein lipase activity(GO:0004465)
0.0	0.1	GO:0005536	glucose binding(GO:0005536)
0.0	0.4	GO:0017022	myosin binding(GO:0017022)
0.0	0.4	GO:0045028	G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0	0.1	GO:0061659	ubiquitin-ubiquitin ligase activity(GO:0034450) ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659)
0.0	0.0	GO:0016842	amidine-lyase activity(GO:0016842)
0.0	0.1	GO:0048018	receptor agonist activity(GO:0048018)
0.0	0.1	GO:0008253	5'-nucleotidase activity(GO:0008253)
0.0	0.1	GO:0008510	sodium:bicarbonate symporter activity(GO:0008510)
0.0	0.0	GO:0008454	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0	0.0	GO:0003836	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0	0.1	GO:0003964	telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964)
0.0	0.1	GO:0008113	peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.0	0.0	GO:0042978	ornithine decarboxylase activator activity(GO:0042978)
0.0	0.1	GO:0043208	glycosphingolipid binding(GO:0043208)
0.0	0.0	GO:0004946	bombesin receptor activity(GO:0004946)
0.0	0.0	GO:0004461	lactose synthase activity(GO:0004461)
0.0	0.0	GO:0004924	oncostatin-M receptor activity(GO:0004924)
0.0	0.0	GO:0016728	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.0	0.0	GO:0008607	phosphorylase kinase regulator activity(GO:0008607)
0.0	0.0	GO:0016901	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor(GO:0016901)
0.0	0.1	GO:0008568	microtubule-severing ATPase activity(GO:0008568)
0.0	0.1	GO:0005499	vitamin D binding(GO:0005499)
0.0	0.0	GO:0004738	pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.0	0.0	GO:0003909	DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.0	0.0	GO:0016151	nickel cation binding(GO:0016151)
0.0	0.1	GO:0004075	biotin carboxylase activity(GO:0004075)
0.0	0.0	GO:0004833	tryptophan 2,3-dioxygenase activity(GO:0004833)
0.0	0.0	GO:0008241	peptidyl-dipeptidase activity(GO:0008241)
0.0	0.0	GO:0016721	superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.0	0.0	GO:0047756	chondroitin 4-sulfotransferase activity(GO:0047756)
0.0	0.1	GO:0004331	fructose-2,6-bisphosphate 2-phosphatase activity(GO:0004331)
0.0	0.0	GO:0004619	bisphosphoglycerate mutase activity(GO:0004082) bisphosphoglycerate 2-phosphatase activity(GO:0004083) phosphoglycerate mutase activity(GO:0004619)
0.0	0.0	GO:0004476	mannose-6-phosphate isomerase activity(GO:0004476)
0.0	0.1	GO:0004908	interleukin-1 receptor activity(GO:0004908)
0.0	0.1	GO:0008195	phosphatidate phosphatase activity(GO:0008195)
0.0	0.0	GO:0004939	beta-adrenergic receptor activity(GO:0004939)
0.0	0.1	GO:0004089	carbonate dehydratase activity(GO:0004089)
0.0	0.1	GO:0003997	acyl-CoA oxidase activity(GO:0003997)
0.0	0.0	GO:0030284	estrogen receptor activity(GO:0030284)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.2	PID ALK2 PATHWAY	ALK2 signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.2	REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.1	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.0	REACTOME PLATELET CALCIUM HOMEOSTASIS	Genes involved in Platelet calcium homeostasis
0.4	REACTOME GPVI MEDIATED ACTIVATION CASCADE	Genes involved in GPVI-mediated activation cascade
0.0	REACTOME APC C CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS	Genes involved in APC/C:Cdc20 mediated degradation of mitotic proteins
0.1	REACTOME P2Y RECEPTORS	Genes involved in P2Y receptors
0.1	REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE	Genes involved in Reversible Hydration of Carbon Dioxide
0.2	REACTOME SYNTHESIS OF PC	Genes involved in Synthesis of PC
0.1	REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR	Genes involved in Trafficking and processing of endosomal TLR
0.3	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.1	REACTOME HYALURONAN METABOLISM	Genes involved in Hyaluronan metabolism